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1. -94 ins/del ATTG NFKB1 gene variant is associated with lower susceptibility to myocardial infarction

Author:
V. Boccardi; M.R. Rizzo; R. Marfella; M. Papa; A. Esposito; M. Portoghese; G. Paolisso; M. Barbieri
Source:
Nutrition, metabolism, and cardiovascular diseases 2011 v.21 no.9 pp. 679-684
ISSN:
0939-4753
Subject:
C-reactive protein; alleles; atherogenesis; biopsy; fibrinogen; gene frequency; genetic polymorphism; genotype; genotyping; human diseases; myocardial infarction; patients; transcription factor NF-kappa B
Abstract:
... BACKGROUND AND AIMS: An imbalance of Nuclear Factor Kappa B (NFкB) and Inhibitor Kappa B (IкB) is involved in various human diseases including atherogenesis. We aimed to evaluate the relationship between NFKB1 and NFKBIA polymorphism and susceptibility to myocardial infarction (MI). METHODS AND RESULTS: Genotyping was performed for NFKB1 and NFKBIA gene variants in 253 subjects (86 patients affect ...
DOI:
10.1016/j.numecd.2009.12.012
PubMed:
20304615

2. 125I-Radiolabeling, Surface Plasmon Resonance, and Quartz Crystal Microbalance with Dissipation: Three Tools to Compare Protein Adsorption on Surfaces of Different Wettability

Author:
Luan Yafei; Li Dan; Wang Yanwei; Liu Xiaoli; Brash John L.; Chen Hong
Source:
Langmuir 2014 v.30 no.4 pp. 1029-1035
ISSN:
1520-5827
Subject:
adsorption; biocompatibility; biocompatible materials; equations; fibrinogen; gold; hydrophilicity; hydrophobicity; models; quartz crystal microbalance; radiolabeling; surface plasmon resonance; wettability
Abstract:
... The extent of protein adsorption is an important consideration in the biocompatibility of biomaterials. Various experimental methods can be used to determine the quantity of protein adsorbed, but the results usually differ. In the present work, self-assembled monolayers (SAMs) were used to prepare a series of model gold surfaces varying systematically in water wettability, from hydrophilic to hydr ...
DOI:
10.1021/la403498w

3. IL- 17A increases ADP-induced platelet aggregation

Author:
Francesco Maione; Carla Cicala; Elisabetta Liverani; Nicola Mascolo; Mauro Perretti; Fulvio D’Acquisto
Source:
Biochemical and biophysical research communications 2011 v.408 no.4 pp. 658-662
ISSN:
0006-291X
Subject:
Western blotting; adenosine diphosphate; antibodies; autoimmune diseases; binding sites; cardiovascular diseases; fibrinogen; humans; interleukin-17; mice; morbidity; patients; phosphorylation; platelet aggregation; risk; turbidity
Abstract:
... The increased risk of thromboembolism and higher incidence of cardiovascular disorders are among the most common causes of morbidity in patients suffering from autoimmune diseases. In this study we tested the hypothesis that IL-17A, a key pro-inflammatory cytokine involved in the development of autoimmune diseases, exerts pro-aggregant effects on both human and mouse platelets. Human or murine pla ...
DOI:
10.1016/j.bbrc.2011.04.080
PubMed:
21530487
PubMed Central:
PMC3182527

4. 17β-Estradiol and the glucocorticoid clobetasol propionate affect the blood coagulation cascade in zebrafish

Author:
Simon Schmid; Karl Fent
Source:
Environmental pollution 2020 v.259 pp. 113808
ISSN:
0269-7491
Subject:
Danio rerio; adverse effects; aquatic environment; blood coagulation; coagulation; contraception; embryo (animal); estradiol; factor VII; fibrinogen; fish; gene expression; gene expression regulation; glucocorticoids; messenger RNA; progestational hormones; propionic acid
Abstract:
... Fish are exposed to estrogens, progestins and glucocorticoids in the aquatic environment but effects on the blood coagulation cascade are unknown. Here we analyzed effects of 17β-estradiol (E2) alone and in combination with mixtures of new generation progestins and the glucocorticoid clobetasol propionate (CLO) in zebrafish embryos to assess their effects on the blood coagulation system. We assess ...
DOI:
10.1016/j.envpol.2019.113808

5. The 3D mechanical environment and chemical milieu influence the hMSC fibrogenesis and fibroblast-to-myofibroblast transition

Author:
Ruodan Xu; Flemming Besenbacher; Menglin Chen
Source:
RSC advances 2016 v.7 no.1 pp. 20-25
ISSN:
2046-2069
Subject:
cytokines; fibrinogen; fibrosis; humans; hydrogels; mesenchymal stromal cells
Abstract:
... The chemical cytokine milieu and the mechanical environment are two central elements in the development and progression of fibrosis. In this study, we demonstrated that, compared to a stiff substrate, a fibrinogen based hydrogel scaffold provided a 3D microenvironment for enhanced human mesenchymal stem cell (hMSC) proliferation, embedded connective tissue growth factor (CTGF) for directed fibroge ...
DOI:
10.1039/c6ra25422e

6. 3d bioprinting of murine cortical astrocytes for engineering neural-like tissue

Author:
de Melo Bruna A. G.; Cruz Elisa M.; Ribeiro Taís N.; Mundim Mayara V.; Porcionatto Marimelia A.
Source:
Journal of visualized experiments 2021 no.173 pp. e62691
ISSN:
1940-087X
Subject:
astrocytes; biocompatible materials; bioprinting; brain; cell growth; fibrinogen; gelatin; laminin; mice; neurons; viability
Abstract:
... Astrocytes are glial cells with an essential role in the central nervous system (CNS), including neuronal support and functionality. These cells also respond to neural injuries and act to protect the tissue from degenerative events. In vitro studies of astrocytes' functionality are important to elucidate the mechanisms involved in such events and contribute to developing therapies to treat neurolo ...
DOI:
10.3791/62691

7. 41 Macleaya cordata phytotherapic supplementation can modulate immune response in ponies fed a high starch diet

Author:
J.R.M. Ferreira; P.A. Ferraz; A.H. da Silva; A.M.C. Araújo Júnior; F.L. Bastos; L.G. Mesquita; G. Pugliesi; A.A.O. Gobesso
Source:
Journal of equine veterinary science 2021 v.100 pp. 103504
ISSN:
0737-0806
Subject:
Macleaya cordata; animal nutrition; antibiotics; body weight; colon; computer software; digestive tract; experimental design; fibrinogen; food additives; gene expression; heat; high carbohydrate diet; immune response; inflammation; interleukins; starch; statistical analysis; ultrasonography; veterinary medicine
Abstract:
... High amounts of grains in equine diet lead to an excessive starch intake modifying microbial populations and fermentative products. These changes could compromise the gastrointestinal barrier which has serious consequences for equine health. Therefore, feed additives are receiving great attention to minimize negative effects related to high starch level inclusion. Macleaya cordata compounds are be ...
DOI:
10.1016/j.jevs.2021.103504

8. 5-Fluorouracil loaded fibrinogen nanoparticles for cancer drug delivery applications

Author:
N. Sanoj Rejinold; M. Muthunarayanan; K.P. Chennazhi; S.V. Nair; R. Jayakumar
Source:
International journal of biological macromolecules 2011 v.48 no.1 pp. 98-105
ISSN:
0141-8130
Subject:
Fourier transform infrared spectroscopy; X-ray diffraction; atomic force microscopy; calcium chloride; cell lines; cytotoxicity; drug delivery systems; fibrinogen; fluorouracil; in vitro studies; nanoparticles; particle size; scanning electron microscopy; ultraviolet-visible spectroscopy
Abstract:
... In this study, 5-flurouracil loaded fibrinogen nanoparticles (5-FU-FNPs) were prepared by two step coacervation method using calcium chloride as cross-linker. The prepared nanoparticles were characterized using DLS, SEM, AFM, FT-IR, TG/DTA and XRD studies. Particle size of 5-FU-FNPs was found to be 150–200nm. The loading efficiency (LE) and in vitro drug release was studied using UV spectrophotome ...
DOI:
10.1016/j.ijbiomac.2010.10.003

9. The A domain of fibronectin-binding protein B of Staphylococcus aureus contains a novel fibronectin binding site

Author:
Burke, Fiona M.; Di Poto, Antonella; Speziale, Pietro; Foster, Timothy J.
Source:
FEBS journal 2011 v.278 no.13 pp. 2359-2371
ISSN:
1742-464X
Subject:
Staphylococcus aureus; adhesins; binding sites; elastin; fibrinogen; fibronectins; protein synthesis; recombinant proteins; tandem repeat sequences
Abstract:
... The fibronectin-binding proteins FnBPA and FnBPB are multifunctional adhesins than can also bind to fibrinogen and elastin. In this study, the N2N3 subdomains of region A of FnBPB were shown to bind fibrinogen with a similar affinity to those of FnBPA (2 μm). The binding site for FnBPB in fibrinogen was localized to the C-terminus of the γ-chain. Like clumping factor A, region A of FnBPB bound to ...
DOI:
10.1111/j.1742-4658.2011.08159.x

10. AFM visualization at a single-molecule level of denaturated states of proteins on graphite

Author:
Nikolay A. Barinov; Valery V. Prokhorov; Evgeniy V. Dubrovin; Dmitry V. Klinov
Source:
Colloids and surfaces 2016 v.146 pp. 777-784
ISSN:
0927-7765
Subject:
adsorption; biocompatibility; biocompatible materials; blood plasma; colloids; denaturation; ferritin; fibrinogen; graphene; human serum albumin; immunoglobulin G; mica; protein denaturation
Abstract:
... Different graphitic materials are either already used or believed to be advantageous in biomedical and biotechnological applications, e.g., as biomaterials or substrates for sensors. Most of these applications or associated important issues, such as biocompatibility, address the problem of adsorption of protein molecules and, in particular the conformational state of the adsorbed protein molecule ...
DOI:
10.1016/j.colsurfb.2016.07.014

11. APTES assisted surface heparinization of polylactide porous membranes for improved hemocompatibility

Author:
Jinglong Li; Fu Liu; Xuemin Yu; Ziyang Wu; Yunze Wang; Zhu Xiong; Jidong He
Source:
RSC advances 2016 v.6 no.48 pp. 42684-42692
ISSN:
2046-2069
Subject:
Fourier transform infrared spectroscopy; X-ray photoelectron spectroscopy; adsorption; artificial membranes; biocompatibility; bovine serum albumin; contact angle; fibrinogen; heparin; hydrophilicity; polylactic acid; prothrombin; reflectance; reflectance spectroscopy; scanning electron microscopes; thromboplastin
Abstract:
... Surface heparinization is considered an efficient strategy to improve the hemocompatibility of polymeric membranes. We aim to realize the feasible surface heparinization of polylactide (PLA) membranes by means of a colourless 3-aminopropyltriethoxysilane (APTES) functionalized platform. APTES conjugated heparin (Hep–APTES) was first synthesized through the amidation reaction and then anchored onto ...
DOI:
10.1039/c6ra04525a

12. Ability of Measures of Adiposity in Identifying Adverse Levels of Inflammatory and Metabolic Markers in Adolescents

Author:
Oliveira-Santos José; Santos Rute; Moreira Carla; Abreu Sandra; Lopes Luís; Agostinis César; Mota Jorge
Source:
Childhood obesity 2016 v.12 no.2 pp. 135-143
ISSN:
2153-2176
Subject:
C-reactive protein; abdominal fat; adiponectin; adiposity; adolescents; body mass index; boys; childhood obesity; complement; cross-sectional studies; erythrocyte sedimentation rate; fibrinogen; girls; leptin; waist circumference; waist-to-height ratio
Abstract:
... Background: Overweight and obesity have been associated with a pro-inflammatory state. We aimed to assess the ability of different measures of overall and abdominal adiposity for identifying adverse levels of inflammatory and metabolic markers in adolescents.Methods: This is a cross-sectional analysis with 529 Portuguese adolescents (267 girls), mean age 14.3 ± 1.7 years. Weight, height, sitting h ...
DOI:
10.1089/chi.2015.0124

13. Abnormal Hemostatic Profiles and Gastric Necrosis in Canine Gastric Dilatation‐Volvulus

Author:
DARRYL L. MILLIS; JOE G. HAUPTMAN; ROBERT B. FULTON
Source:
Veterinary surgery 1993 v.22 no.2 pp. 93-97
ISSN:
0161-3499
Subject:
blood platelet count; disseminated intravascular coagulation; dogs; equations; fibrin; fibrinogen; necropsy; necrosis; prothrombin; regression analysis; surgery; thromboplastin
Abstract:
... Hemostatic profiles (prothrombin time, activated partial thromboplastin time, fibrinogen concentration, fibrin degradation product concentration, platelet count, and antithrombin III activity) were acquired prospectively in 20 dogs with a diagnosis of gastric dilatation‐volvulus. Eighteen dogs had abnormal results of one or more hemostatic test, including eight dogs that had hemostatic profiles co ...
DOI:
10.1111/j.1532-950X.1993.tb01680.x

14. Abomasal ulcers: Do ranitidine or omeprazole prevent phenylbutazone-induced lesions in sheep?

Author:
Aline Alberti Morgado; Lilian Rose Marques de Sá; Maria Claudia Araripe Sucupira
Source:
Small ruminant research 2022 v.216 pp. 106782
ISSN:
0921-4488
Subject:
adults; blood serum; experimental design; fibrinogen; heart rate; intravenous injection; mucosa; nonsteroidal anti-inflammatory agents; phenylbutazone; phlebitis; research; sheep
Abstract:
... Treatment and prevention of gastric ulcers are well known in monogastric animals; however, there are uncertainties about the preventive effects of acid-reducer drugs, their dosages and the best route of administration to ruminants. The object of this research was to test the preventive actions of ranitidine and omeprazole on abomasal ulcer development in sheep treated with a high dosage of non-ste ...
DOI:
10.1016/j.smallrumres.2022.106782

15. Acclimation to cold and warm temperatures is associated with differential expression of male carp blood proteins involved in acute phase and stress responses, and lipid metabolism

Author:
Mariola A. Dietrich; Piotr Hliwa; Mikołaj Adamek; Dieter Steinhagen; Halina Karol; Andrzej Ciereszko
Source:
Fish & shellfish immunology 2018 v.76 pp. 305-315
ISSN:
1050-4648
Subject:
acclimation; adrenal cortex hormones; ambient temperature; antioxidants; apolipoproteins; biomarkers; blood plasma; carp; cold; complement; fetuins; fibrinogen; free radicals; gel electrophoresis; gene expression regulation; haptoglobins; hemoglobin; immune response; kininogens; lipid metabolism; males; matrix-assisted laser desorption-ionization mass spectrometry; neutralization; proteinases; proteome; stress response
Abstract:
... The environmental temperature affects plasma biochemical indicators, antioxidant status and hematological and immunological parameters in fish. So far, only single blood proteins have been identified in response to temperature changes. The aim of this study was to compare the proteome of carp blood plasma from males acclimated to warm (30 °C) and cold (10 °C) temperatures by two-dimensional differ ...
DOI:
10.1016/j.fsi.2018.03.018

16. Acetylation and glycation of fibrinogen in vitro occur at specific lysine residues in a concentration dependent manner: A mass spectrometric and isotope labeling study

Author:
Jan Svensson; Ann-Charlotte Bergman; Ulf Adamson; Margareta Blombäck; Håkan Wallén; Gun Jörneskog
Source:
Biochemical and biophysical research communications 2012 v.421 no.2 pp. 335-342
ISSN:
0006-291X
Subject:
acetylation; aspirin; crosslinking; diabetes; fibrin; fibrinogen; glucose; glycation; isotope labeling; lysine; mass spectrometry; salicylic acid
Abstract:
... Aspirin may exert part of its antithrombotic effects through platelet-independent mechanisms. Diabetes is a condition in which the beneficial effects of aspirin are less prominent or absent – a phenomenon called “aspirin resistance”. We investigated whether acetylation and glycation occur at specific sites in fibrinogen and if competition between glucose and aspirin in binding to fibrinogen occurs ...
DOI:
10.1016/j.bbrc.2012.03.154

17. Acoustic determination of performance and equivalence of plasminogen activators

Author:
Mirnader Ghazali; Gordon L. Hayward
Source:
Analytical and bioanalytical chemistry 2008 v.392 no.5 pp. 897-902
ISSN:
1618-2642
Subject:
acoustics; cost effectiveness; fibrin; fibrinogen; plasminogen; quartz; thrombin; u-plasminogen activator
Abstract:
... A reliable method for the measurement of different plasminogen activators is of great interest for both manufacturing and clinical medicine. A one-step assay based on a thickness shear mode acoustic sensor has been developed for this purpose. Two separate mixtures of substrates (fibrinogen and plasminogen) and enzymes (thrombin and the plasminogen activator) were mixed, and placed on the acoustic ...
DOI:
10.1007/s00216-008-2343-y

18. Actinidia arguta supplementation protects aorta and liver in rats with induced hypercholesterolemia

Author:
Maria Leontowicz; Hanna Leontowicz; Iwona Jesion; Wojciech Bielecki; Katarzyna Najman; Piotr Latocha; Yong-Seo Park; Shela Gorinstein
Source:
Nutrition research 2016 v.36 no.11 pp. 1231-1242
ISSN:
0271-5317
Subject:
2,2-diphenyl-1-picrylhydrazyl; Actinidia arguta; antioxidant activity; aorta; blood serum; cholesterol; diet; fatty liver; fibrinogen; hypercholesterolemia; kiwifruit; laboratory animals; lipid composition; liver; males; prothrombin; rats; villi; Poland
Abstract:
... There are no published results focusing on the study of hardy kiwifruit as a supplementation to the atherogenic diet. We hypothesized that hardy kiwifruit (Actinidia arguta (A. arguta)) from Poland possess better pro-healthy action than two Asian varieties (Hayward and Bidan). We tested this hypothesis by measuring the metabolic reactions of rats loaded with 1% cholesterol and supplemented with 5% ...
DOI:
10.1016/j.nutres.2016.09.010

19. Actinobacillus seminis GroEL-homologous protein agglutinates sheep erythrocytes

Author:
Juan Fernando Montes-García; Willy Angel Delgado-Tapia; Candelario Vazquez-Cruz; Sergio Vaca; Ariadnna Cruz-Córdova; Erasmo Negrete-Abascal
Source:
Antonie van Leeuwenhoek 2019 v.112 no.11 pp. 1655-1662
ISSN:
0003-6072
Subject:
Actinobacillus seminis; Gallibacterium anatis; adhesins; adhesion; bacteria; biofilm; bladder; blood serum; epididymitis; erythrocytes; fibrinogen; fibronectins; goats; hemagglutinins; humans; mass spectrometry; peroxidase; polyclonal antibodies; sequence analysis; sheep; transmission electron microscopy
Abstract:
... Actinobacillus seminis, a commensal of ovine and caprine reproductive organs, is able to induce epididymitis in the small ruminants that it infects. In this work, we characterised two protein bands of approximately 150 kDa and 65 kDa. These proteins cross-reacted with a polyclonal serum against Gallibacterium anatis hemagglutinin and with a polyclonal serum from sheep with epididymitis, indicating ...
DOI:
10.1007/s10482-019-01292-6

20. Active Release of an Antimicrobial and Antiplatelet Agent from a Nonfouling Surface Modification

Author:
Marcus J. Goudie; Priyadarshini Singha; Sean P. Hopkins; Elizabeth J. Brisbois; Hitesh Handa
Source:
ACS applied materials & interfaces 2019 v.11 no.4 pp. 4523-4530
ISSN:
1944-8252
Subject:
Staphylococcus aureus; adhesion; antifouling activities; bacterial adhesion; blood platelets; fibrinogen; medical equipment; nitric oxide; silicone; thrombosis
Abstract:
... Two major challenges faced by medical devices are thrombus formation and infection. In this work, surface-tethered nitric oxide (NO)-releasing molecules are presented as a solution to combat infection and thrombosis. These materials possess a robust NO release capacity lasting ca. 1 month while simultaneously improving the nonfouling nature of the material by preventing platelet, protein, and bact ...
DOI:
10.1021/acsami.8b16819

21. The Acute Effects of Fine Particulate Matter Constituents on Blood Inflammation and Coagulation

Author:
Cong Liu; Jing Cai; Liping Qiao; Hongli Wang; Wenxi Xu; Huichu Li; Zhuohui Zhao; Renjie Chen; Haidong Kan
Source:
Environmental science & technology 2017 v.51 no.14 pp. 8128-8137
ISSN:
1520-5851
Subject:
C-reactive protein; acute effects; ammonium; biomarkers; blood; chemokine CCL2; coagulation; environmental science; fibrinogen; inflammation; intercellular adhesion molecule-1; ligands; models; nitrates; organic carbon; particulates; plasminogen activator inhibitors; sulfates; tumor necrosis factor-alpha; vascular cell adhesion molecules; China
Abstract:
... Limited evidence is available on the effects of various fine particulate matter (PM₂.₅) constituents on blood inflammation and coagulation. We examined the associations between 10 constituents and 10 circulating biomarkers in a panel of 28 urban residents with four repeated measurements in Shanghai, China. Based on the linear mixed-effect models, we fitted the single-constituent models, the consti ...
DOI:
10.1021/acs.est.7b00312

22. Acute Phase Protein Response in Goats

Author:
Félix H. D. González; Fernando Tecles; Silvia Martínez-Subiela; Asta Tvarijonaviciute; Laura Soler; José J. Cerón
Source:
Journal of veterinary diagnostic investigation v.20 no.5 pp. 580-584
ISSN:
1040-6387
Subject:
acute phase proteins; albumins; amyloid; analytical methods; blood serum; fibrinogen; goats; haptoglobins; heat; oils; subcutaneous injection; turpentine
Abstract:
... Acute phase proteins (APPs) are important diagnostic indicators of inflammatory disturbances in animals. The objectives of the current study were to validate analytical methods for measuring haptoglobin (Hp), serum amyloid A (SAA), acid soluble glycoprotein (ASG), fibrinogen, and albumin concentrations in goats and to evaluate their response to an inflammatory stimulus in this species. Intra- and ...
DOI:
10.1177/104063870802000507

23. Acute Phase Proteins in Experimentally Induced Pregnancy Toxemia in Goats

Author:
Félix H. D. González; Fuensanta Hernández; Josefa Madrid; Silvia Martínez-Subiela; Asta Tvarijonaviciute; José J. Cerón; Fernando Tecles
Source:
Journal of veterinary diagnostic investigation v.23 no.1 pp. 57-62
ISSN:
1040-6387
Subject:
3-hydroxybutyric acid; acute phase proteins; adults; albumins; amyloid; blood; fasting; fibrinogen; free fatty acids; glycoproteins; goats; ketonuria; pH; pregnancy; pregnancy toxemia; urine
Abstract:
... The present work aimed to study the behavior of acute phase proteins (haptoglobin, serum amyloid A, acid soluble glycoprotein, fibrinogen, and albumin) in fasting-induced pregnancy toxemia in goats and their relationship with classical indicators of this disorder such as beta-hydroxybutyrate and nonesterified fatty acids in the blood and decreased urine pH and ketonuria. Twelve adult Murciano–Gran ...
DOI:
10.1177/104063871102300108
PubMed:
21217028

24. The Acute Phase Response in Calves Experimentally Infected with Bovine Viral Diarrhoea Virus and/or Mannheimia haemolytica

Author:
Ganheim, C.; Hulten, C.; Carlsson, U.; Kindahl, H.; Niskanen, R.; Waller, K.P.
Source:
Journal of veterinary medicine. Series B. 2003 v.50 no.4 pp. 183-190
ISSN:
0931-1793
Subject:
blood serum; fibrinogen; herds; respiratory system; Mannheimia haemolytica; Bovine viral diarrhea virus 1; amyloid; prostaglandins; cortisol; calves; haptoglobins; acute phase proteins
Abstract:
... The aim of this investigation was to study differences and similarities in the acute phase response of calves experimentally infected in the respiratory tract with either bovine viral diarrhoea virus (BVDV) or Mannheima haemolytica (Mh), or with a combination of both (BVDV/Mh). A non-inoculated control group was also included. The acute phase response was measured by serum or plasma concentrations ...
DOI:
10.1046/j.1439-0450.2003.00658.x

25. Acute Phase Response to Surgery of Varying Intensity in Horses: A Preliminary Study

Author:
Jacobsen, S.; Nielsen, J. V.; Kjelgaard-Hansen, M.; Toelboell, T.; Fjeldborg, J.; Halling-Thomsen, M.; Martinussen, T.; Thoefner, M. B.
Source:
Veterinary surgery 2009 v.38 no.6 pp. 762-769
ISSN:
0161-3499
Subject:
horses; horse diseases; postoperative complications; acute course; osteochondrosis; ovarian neoplasms; laparotomy; ovariectomy; fibrinogen; iron; inflammation; prospective studies; longitudinal studies
Abstract:
... To evaluate the postoperative inflammatory response of horses to elective surgery of varying intensity. Prospective longitudinal study. Horses referred to 2 hospitals for either arthroscopic removal of a unilateral osteochondritic lesion in the tibiotarsal joint (minimal surgical trauma, n=11), correction of recurrent laryngeal neuropathy by laryngoplasty and ventriculectomy (intermediate surgical ...
DOI:
10.1111/j.1532-950X.2009.00564.x
PubMed:
19674420

26. Acute exercise does not induce an acute phase response (APR) in Standardbred trotters

Author:
Kristensen, Lena; Buhl, Rikke; Nostell, Katarina; Bak, Lars; Petersen, Ellen; Lindholm, Maria; Jacobsen, Stine
Source:
Canadian journal of veterinary research 2014 v.78 no.2 pp. 97-102
ISSN:
0830-9000
Subject:
Standardbred; amyloid; anemia; aspartate transaminase; blood serum; creatinine; exercise; fibrinogen; haptoglobins; hemoglobin; hemolysis; horses; humans; iron; leukocyte count; leukocytes; muscles; pathogenesis
Abstract:
... The purpose of the study was to investigate whether acute strenuous exercise (1600- to 2500-m race) would elicit an acute phase response (APR) in Standardbred trotters. Blood levels of several inflammatory markers [serum amyloid A (SAA), haptoglobin, fibrinogen, white blood cell count (WBC), and iron], muscle enzymes [creatinine kinase (CK) and aspartate transaminase (AST)], and hemoglobin were as ...

27. Acute phase protein levels in pregnancy and oestrus cycle in bitches

Author:
Ulutas, Pinar Alkim; Musal, Bayazit; Kiral, Funda; Bildik, Aysegul
Source:
Research in veterinary science 2009 v.86 no.3 pp. 373-376
ISSN:
0034-5288
Subject:
temporal variation; C-reactive protein; ferroxidase; proestrus; fibrinogen; dogs; haptoglobins; anestrus; progesterone; pregnancy; animal health; pregnancy diagnosis; diestrus; estradiol; estrus; females
Abstract:
... The purpose of this study was to evaluate the acute phase protein (serum amyloid A, C-reactive protein, haptoglobin, ceruloplasmin and fibrinogen) profiles in pregnant dogs as well as bitches at various stages of the estrus cycle and to verify possible relationship(s) among the APPs profile and hormonal status. A total of 60 bitches of various breeds were enrolled. The animals were divided into si ...
DOI:
10.1016/j.rvsc.2008.09.001
PubMed:
18995874

28. Acute phase proteins as indicators of calf herd health

Author:
Ganheim, C.; Alenius, S.; Persson Waller, K.
Source:
Veterinary journal 2007 v.173 no.3 pp. 645-651
ISSN:
1090-0233
Subject:
cattle diseases; monitoring; fibrinogen; herd health; disease control; lungworms; seroconversion; calves; haptoglobins; acute phase proteins
Abstract:
... The potential for using acute phase proteins (APPs) in the assessment of herd health was studied by examining the levels of serum haptoglobin, serum amyloid A (SAA) and plasma fibrinogen in relation to clinical findings and leukocyte counts in calves. Two groups of calves from conventional dairy farms were studied. The animals were examined 10 times during the first six weeks after introduction in ...
DOI:
10.1016/j.tvjl.2006.01.011
PubMed:
16546422

29. Acute phase proteins in Andalusian horses infected with Theileria equi

Author:
Rocío Rodríguez; José J. Cerón; Cristina Riber; Francisco Castejón; Manuel Gómez-Díez; Juan M. Serrano-Rodríguez; Ana Muñoz
Source:
veterinary journal 2014 v.202 no.1 pp. 182-183
ISSN:
1090-0233
Subject:
Theileria equi; acute phase proteins; amyloid; anemia; anorexia; blood serum; fibrinogen; haptoglobins; inflammation; mares; pastures; polymerase chain reaction; stallions; theileriosis; Spain
Abstract:
... Clinical and laboratory findings were determined in 23 Andalusian horses in southern Spain that were positive for Theileria equi by PCR, including 16 mares at pasture (group A1) and seven stabled stallions (group B1). Five healthy mares at pasture (group A2) and five stabled stallions (group B2), all of which were negative for T. equi in Giemsa stained blood smears and by PCR, were used as control ...
DOI:
10.1016/j.tvjl.2014.07.003

30. Acute phase response in cattle infected with Anaplasma marginale

Author:
S. Nazifi; S.M. Razavi; F. Kaviani; E. Rakhshandehroo
Source:
Veterinary microbiology 2012 v.155 no.2-4 pp. 267-271
ISSN:
0378-1135
Subject:
Anaplasma marginale; acute phase proteins; cattle; erythrocyte count; erythrocytes; farms; ferroxidase; fibrinogen; lipids; protein binding; sialic acids
Abstract:
... This study was undertaken to evaluate the acute phase responses via the assessment of the concentration of serum sialic acids (total, lipid bound and protein bound), inflammatory mediators (IFN-γ and TNF-α) and acute phase proteins (Hp and SAA) in 20 adult crossbred cattle naturally infected by Anaplasma marginale. The infected animals were divided into 2 subgroups on the basis of parasitemia rate ...
DOI:
10.1016/j.vetmic.2011.08.024
PubMed:
21940118

31. Acute phase response in the primiparous dairy cows after repeated percutaneous liver biopsy during the transition period

Author:
P. Jawor; A. Brzozowska; K. Słoniewski; Z.M. Kowalski; T. Stefaniak
Source:
Polish journal of veterinary sciences 2016 v.19 no.2 pp. 393-399
ISSN:
2300-2557
Subject:
amyloid; biopsy; blood sampling; blood serum; body temperature; calving; dairy cows; fibrinogen; haptoglobins; interleukin-6; liver
Abstract:
... The aim of this study was to evaluate the acute phase response of dairy cows to repeated liver biopsy in order to estimate the safety of this procedure during the transition period. Liver biopsies (up to 1000 mg of liver tissue) were conducted twice a day, 7 days before expected parturition and 3 days after calving. The number of needle insertions for each biopsy was recorded and was dependent on ...
DOI:
10.1515/pjvs-2016-0049

32. Acute-phase protein profile in horses subjected to different exercise protocols

Author:
P. Assuncao; T. Barbosa; L. Yonezawa; L. Barbosa; M. Watanabe; A. Kohayagawa; E. Schmidt
Source:
Canadian journal of veterinary research 2019 v.83 no.4 pp. 272-278
ISSN:
0830-9000
Subject:
acute phase proteins; albumins; automation; blood sampling; blood serum; catecholamines; centrifugation; creatine kinase; exercise; fibrinogen; haptoglobins; heat; hematocrit; hemolysis; horses; muscles; physiological response; polyacrylamide gel electrophoresis; protein content; purebreds; veterinary medicine
Abstract:
... High-intensity exercise can be associated with the occurrence of muscle injury, as well as the induction of an acute-phase response (APR). The present study aims to investigate the synthesis and profile of serum proteins in horses before and after participating in 2 different exercise protocols and to relate this profile to the presence or absence of muscular injury caused by exercise. Ten purebre ...

33. Acute-phase proteins: As a diagnostic tool in pneumonic dromedary Camel

Author:
Marwa Ahmed; Sary Khaleel Abd Elghaffar; Gehad Khaled Ali
Source:
SVU- International Journal of Veterinary Sciences 2021 v.4 no.2 pp. 51-59
ISSN:
2535-1877
Subject:
C-reactive protein; Camelus dromedarius; animal health; blood; bronchopneumonia; diagnostic techniques; fibrinogen; haptoglobins; histopathology; liver; lungs
Abstract:
... Determining the health of animals is important. So, acute-phase proteins consider as important markers of animal health. The acute-phase response is characterized by increased circulating levels of acute-phase proteins released by the liver. In addition, pneumonia is an emerging problem in dromedary camels, with no data available on the diagnostic significance of the markers of acute phase protein ...
DOI:
10.21608/SVU.2021.61186.1107

34. Acute‐phase proteins as diagnostic markers in horses with colic

Author:
Tina H. Pihl; Elrien Scheepers; Macarena Sanz; Amelia Goddard; Patrick Page; Nils Toft; Mads Kjelgaard‐Hansen; Pia H. Andersen; Stine Jacobsen
Source:
Journal of veterinary emergency and critical care 2016 v.26 no.5 pp. 664-674
ISSN:
1479-3261
Subject:
acute phase proteins; amyloid; blood serum; colic; fibrinogen; graphs; haptoglobins; hemolysis; horses; hospitals; lactic acid; leukocytes; logit analysis; medical treatment; models; peritonitis; protein content; risk; surgery; temperature
Abstract:
... OBJECTIVE: To investigate the diagnostic potential of the concentrations of acute‐phase proteins serum amyloid A (SAA), haptoglobin (Hp), and fibrinogen in blood and peritoneal fluid (PF) for differentiating horses with inflammatory colic (entero‐colitis and peritonitis) from those with surgical colic. DESIGN: Prospective observational multicenter study. SETTING: Two university referral hospitals. ...
DOI:
10.1111/vec.12504

35. Adherence by Staphylococcus intermedius to canine corneocytes: a preliminary study comparing noninflamed and inflamed atopic canine skin

Author:
McEwan, Neil A.; Mellor, Dominic; Kalna, Gabriel
Source:
Veterinary dermatology 2006 v.17 no.2 pp. 151-154
ISSN:
0959-4493
Subject:
Staphylococcus aureus; bacterial colonization; epidemiology; dog diseases; adhesins; dogs; fibrinogen; inflammation; bacterial adhesion; binding properties; strain differences; epidermis (animal); physiological response; atopic dermatitis; pathogenesis; fibronectins; bacterial infections
Abstract:
... The adherence by three strains of Staphylococcus intermedius to corneocytes collected from healthy dogs was compared to the adherence to corneocytes collected from the inflamed (erythematous) and noninflamed (normal appearing) skin of dogs suffering from atopic dermatitis. All three strains of S. intermedius adhered in greater numbers to corneocytes from both inflamed and noninflamed atopic skin t ...
DOI:
10.1111/j.1365-3164.2006.00503.x
PubMed:
16515659

36. Adherence characteristics of endocarditis-derived Streptococcus gallolyticus ssp. gallolyticus (Streptococcus bovis biotype I) isolates to host extracellular matrix proteins

Author:
Sillanpää, Jouko; Nallapareddy, Sreedhar R.; Singh, Kavindra V.; Ferraro, Mary J.; Murray, Barbara E.
Source:
FEMS microbiology letters 2008 v.289 no.1 pp. 104-109
ISSN:
0378-1097
Subject:
Streptococcus bovis; Streptococcus gallolyticus; Streptococcus infantarius; collagen; endocarditis; extracellular matrix; fibrinogen; fibronectins; humans; intestines; pathogenicity; pathogens; phenotype; pulsed-field gel electrophoresis; tissues
Abstract:
... Members of the Streptococcus bovis group are frequent colonizers of the intestinal tract, which can also cause endocarditis. However, their ability to adhere to and colonize host tissues and the factors associated with pathogenicity are largely unknown. Here, we assessed 17 endocarditis-derived human isolates [identified here as 15 Streptococcus gallolyticus ssp. gallolyticus (S. bovis biotype I), ...
DOI:
10.1111/j.1574-6968.2008.01378.x
PubMed:
19054100

37. Adherence to DASH-Style Dietary Pattern Impacts on Adiponectin and Clustered Metabolic Risk in Older Women

Author:
Andreas Nilsson; Patrik Halvardsson; Fawzi Kadi
Source:
Nutrients 2019 v.11 no.4 pp. -
ISSN:
2072-6643
Subject:
C-reactive protein; accelerometry; adiponectin; biomarkers; blood glucose; chronic diseases; cross-sectional studies; diastolic blood pressure; elderly; fibrinogen; food records; glucose; healthy eating habits; high density lipoprotein; hypertension; inflammation; physical activity; public health; risk factors; triacylglycerols; waist circumference; women
Abstract:
... While dietary patterns are related to the age-related progression of chronic diseases, to what extent different dietary patterns influence inflammatory and metabolic risk factors in older adults remains to be elucidated. Additionally, potential moderating effects by physical activity (PA) become important to clarify. Here, we hypothesize that dietary patterns are linked to inflammatory and metabol ...
DOI:
10.3390/nu11040805
PubMed:
30970648
PubMed Central:
PMC6520850

38. Adherence to and Invasion of Human Brain Microvascular Endothelial Cells Are Promoted by Fibrinogen-Binding Protein FbsA of Streptococcus agalactiae

Author:
Tenenbaum, Tobias; Bloier, Christiane; Adam, Růdiger; Reinscheid, Dieter J.; Schroten, Horst
Source:
Infection and immunity 2005 v.73 no.7 pp. 4404-4409
ISSN:
0019-9567
Subject:
Lactococcus lactis; Streptococcus agalactiae; bacteria; brain; chemoattractants; endothelial cells; epitopes; fibrinogen; gene expression; genes; humans; interleukin-8; meningitis; monoclonal antibodies; mutants; neonates
Abstract:
... Streptococcus agalactiae is a frequent cause of bacterial sepsis and meningitis in neonates. During the course of infection, S. agalactiae colonizes and invades a number of host compartments, thereby interacting with different host tissues. Deletion of the fbsA gene, encoding the fibrinogen protein FbsA, significantly impaired the adherence and invasion of human brain microvascular endothelial cel ...
DOI:
10.1128/IAI.73.7.4404-4409.2005
PubMed:
15972538
PubMed Central:
PMC1168575

39. Adherence to dietary approaches to stop hypertension (DASH) and Mediterranean dietary patterns in relation to cardiovascular risk factors in older adults

Author:
Yahya Jalilpiran; Manije Darooghegi Mofrad; Hadis Mozaffari; Nick Bellissimo; Leila Azadbakht
Source:
Clinical nutrition ESPEN 2020 v.39 pp. 87-95
ISSN:
2405-4577
Subject:
C-reactive protein; Dietary Approaches to Stop Hypertension diet; biomarkers; cardiovascular diseases; clinical nutrition; cross-sectional studies; diastolic blood pressure; eating habits; elderly; fibrinogen; food intake; insulin; longitudinal studies; men; odds ratio; regression analysis; risk factors; risk reduction; triacylglycerols; waist circumference; Iran
Abstract:
... The aging process is associated with several chronic diet-related complications, including cardiovascular diseases. Therefore, the objective was to examine the association between DASH and Mediterranean dietary pattern (MDP) on cardiovascular risk factors and inflammatory markers in older adult men.A cross-sectional study was performed on 357 older adult men who were randomly selected from health ...
DOI:
10.1016/j.clnesp.2020.07.013

40. Adherence to host extracellular matrix and serum components by Enterococcus faecium isolates of diverse origin

Author:
Zhao, Meng; Sillanpää, Jouko; Nallapareddy, Sreedhar R.; Murray, Barbara E.
Source:
FEMS microbiology letters 2009 v.301 no.1 pp. 77-83
ISSN:
0378-1097
Subject:
Enterococcus faecium; blood serum; collagen; cross infection; extracellular matrix; fibrinogen; fibronectins; lactoferrin; laminin; pathogens; phenotype; transferrin
Abstract:
... Enterococcus faecium has emerged as an important cause of nosocomial infections over the last two decades. We recently demonstrated collagen type I (CI) as a common adherence target for some E. faecium isolates and a significant correlation was found to exist between acm-mediated CI adherence and clinical origin. Here, we evaluated 60 diverse E. faecium isolates for their adherence to up to 15 imm ...
DOI:
10.1111/j.1574-6968.2009.01806.x
PubMed:
19843310
PubMed Central:
PMC2783522

41. Adhesion and friction forces in biofouling attachments to nanotube- and PEG- patterned TiO2 surfaces

Author:
Rong An; Yihui Dong; Jiahua Zhu; Chao Rao
Source:
Colloids and surfaces 2017 v.159 pp. 108-117
ISSN:
0927-7765
Subject:
adhesion; adsorption; bacteria; biofouling; coatings; colloids; deformation; fibrinogen; friction; nanotubes; surface roughness; titanium dioxide; topography
Abstract:
... The TiO2 nanotube pattern with features down to 20nm (TN20) is highly and efficiently resistant to fibrinogen and S. aureus attachment. The ability of TN20 to resist biofouling adsorption, is due to low biofouling-surface adhesion force that determines the initial biofouling attachment, as well as the low friction coefficient that enables a complete removal of biofouling from a low-adhesive ‘repel ...
DOI:
10.1016/j.colsurfb.2017.07.067

42. Adhesion of Blood Clots Can Be Enhanced When Copolymerized with a Macromer That Is Crosslinked by Coagulation Factor XIIIa

Author:
Chan Karen Y. T.; Zhao Chunyi; Siren Erika M. J.; Chan Jeanne C. Y.; Boschman Jeffrey; Kastrup Christian J.
Source:
Biomacromolecules 2016 v.17 no.6 pp. 2248-2252
ISSN:
1526-4602
Subject:
adhesion; blood coagulation; blood vessels; coagulation; crosslinking; fibrin; fibrinogen; hemostasis; polymers; protein-glutamine gamma-glutamyltransferase; synthetic products
Abstract:
... The adhesion of blood clots to blood vessels, such as through the adhesion of fibrin, is essential in hemostasis. While numerous strategies for initiating clot formation and preventing clot lysis are being developed to create improved hemostatic agents, strategies for enhancing clot adhesion have not been widely explored. Here, we show that adhesion of blood clots can be increased by adding a prev ...
DOI:
10.1021/acs.biomac.6b00481
PubMed:
27140446
PubMed Central:
PMC5496764

43. Adhesion of Blood Plasma Proteins and Platelet-rich Plasma on l-Valine-Based Poly(ester urea)

Author:
Childers Erin P.; Peterson Gregory I.; Ellenberger Alex B.; Domino Karen; Seifert Gabrielle V.; Becker Matthew L.
Source:
Biomacromolecules 2016 v.17 no.10 pp. 3396-3403
ISSN:
1526-4602
Subject:
absorption; adhesion; adsorption; biocompatible materials; blood plasma; bovine serum albumin; coatings; fibrinogen; in vitro studies; polymers; quartz; rats; surface tension; water uptake
Abstract:
... The competitive absorption of blood plasma components including fibrinogen (FG), bovine serum albumin (BSA), and platelet-rich plasma (PRP) on l-valine-based poly(ester urea) (PEU) surfaces were investigated. Using four different PEU polymers, possessing compositionally dependent trends in thermal, mechanical, and critical surface tension measurements, water uptake studies were carried out to dete ...
DOI:
10.1021/acs.biomac.6b01195

44. Adhesion properties of Lactobacillus casei strains to resected intestinal fragments and components of the extracellular matrix

Author:
Muñoz-Provencio, Diego; Llopis, Marta; Antolín, María; de Torres, Inés; Guarner, Francisco; Pérez-Martínez, Gaspar; Monedero, Vicente
Source:
Archives of microbiology 2009 v.191 no.2 pp. 153-161
ISSN:
0302-8933
Subject:
Lactobacillus casei; adhesion; cheeses; collagen; colon; extracellular matrix; fibrinogen; fibronectins; humans; hydrophobicity; intestinal mucosa; lactic acid bacteria; mucins; probiotics; solvents; surface proteins
Abstract:
... Adhesion to intestinal epithelium is an outcome property for the selection of probiotic lactic acid bacteria strains. We have analyzed the adhesion properties of a collection of Lactobacillus casei strains from different origins, ranging from cheese isolates to commercial probiotics. Analysis of the surface characteristics of the strains by measuring adhesion to solvents (MATS test) showed that mo ...
DOI:
10.1007/s00203-008-0436-9

45. Adipokines as atherothrombotic risk factors in obese subjects: Associations with haemostatic markers and common carotid wall thickness

Author:
É. Csongrádi; M. Káplár; B. Nagy; C.A. Koch; A. Juhász; L. Bajnok; Z. Varga; I. Seres; Z. Karányi; M.T. Magyar; L. Oláh; A. Facskó; J. Kappelmayer; G. Paragh
Source:
Nutrition, metabolism, and cardiovascular diseases 2017 v.27 no.6 pp. 571-580
ISSN:
0939-4753
Subject:
adiponectin; antigens; atherosclerosis; blood platelet count; coagulation; comorbidity; enzyme-linked immunosorbent assay; factor VIII; fibrinogen; flow cytometry; interleukin-6; leptin; metabolism; microparticles; patients; plasminogen activator inhibitors; platelet activation; resistin; risk factors; tumor necrosis factor-alpha; ultrasonography
Abstract:
... Some crucial associations between obesity-related altered adipokine levels and the main factors of atherosclerotic, atherothrombotic processes are not fully known. We analysed the relationships of classic adipokines, namely leptin, resistin, adiponectin, tumour necrosis factor-alpha (TNF-α), interleukin 6 (IL-6) with the markers of platelet activation, including mean platelet volume (MPV), platele ...
DOI:
10.1016/j.numecd.2017.02.007

46. Adipose tissue, insulin action and vascular disease: inflammatory signals

Author:
Yudkin, J.S.
Source:
International journal of obesity 2003 v.27 no.3 pp. S25
ISSN:
0307-0565
Subject:
C-reactive protein; adipocytes; adipokines; adipose tissue; albuminuria; endothelium; fibrinogen; inflammation; insulin; insulin resistance; interleukin-6; liver; obesity; phenotype; plasminogen activator; skeletal muscle
Abstract:
... Insulin resistance, both in nondiabetic and diabetic subjects, is frequently associated with obesity, particularly an excess of central fat. Many of the features that have been ascribed to the metabolic or insulin-resistance syndrome are also more commonly found in obese subjects. These phenotypes include diabetic dyslipidaemia, elevation of levels of plasminogen activator inhibitor-1, microalbumi ...
DOI:
10.1038/sj.ijo.0802496

47. Adjustable Bioadhesive Control of PEGylated Hyperbranch Brushes on Polystyrene Microplate Interface for the Improved Sensitivity of Human Blood Typing

Author:
Chen Yan-Wen; Chang Yung; Lee Rong-Ho; Li Wen-Tyng; Chinnathambi Arunachalam; Alharbi Sulaiman Ali; Hsiue Ging-Ho
Source:
Langmuir 2014 v.30 no.30 pp. 9139-9146
ISSN:
1520-5827
Subject:
absorption; agglutination; blood groups; blood platelets; blood transfusion; chemical bonding; erythrocytes; fibrinogen; hematocrit; humans; monoclonal antibodies; ozone; physical properties; polystyrenes; risk; screening
Abstract:
... A PEGylated 96-well polystyrene (PS) microplate was first introduced for applications in high-throughput screening for selective blood typing to minimize the risks in blood transfusions. Herein, we present a hemocompatible PS 96-well microplate with adjustable PEGylated hyperbranch brush coverage prepared by ozone pretreated activation and thermally induced surface PEGylation. The grafting propert ...
DOI:
10.1021/la501396e

48. Administration of dexamethasone per os in finishing bulls. II. Effects on blood parameters used as indicators of animal welfare

Author:
Marin, A.; Pozza, G.; Gottardo, F.; Moro, L.; Stefani, A.L.; Cozzi, G.; Brscic, M.; Andrighetto, I.; Ravarotto, L.
Source:
Animal 2008 v.2 no.7 pp. 1080-1086
ISSN:
1751-7311
Subject:
cattle feeding; beef bulls; fibrinogen; animal welfare; animal stress; biomarkers; dosage; leukocytes; hematology; finishing; cortisol; dexamethasone; oral administration; globulins
Abstract:
... A set of hormonal, haematological and biochemical parameters was used to evaluate the physiological response and welfare status of 14 finishing Marchigiana bulls treated for 49 days with a low daily dosage (0.75 mg/head per day) of dexamethasone per os. Compared to the Control group, dexamethasone decreased cortisol concentrations (42.3 v. 5.7 nmol/l; s.e.d. = 4.17; P < 0.001), and led to the reve ...
DOI:
10.1017/S1751731108002061
PubMed:
22443709

49. AdpC Is a Prevotella intermedia 17 Leucine-Rich Repeat Internalin-Like Protein

Author:
Iyer, Divya; Anaya-Bergman, Cecilia; Jones, Kevin; Yanamandra, Sai; Sengupta, Dipanwita; Miyazaki, Hiroshi; Lewis, Janina P.
Source:
Infection and immunity 2010 v.78 no.6 pp. 2385-2396
ISSN:
0019-9567
Subject:
human umbilical vein endothelial cells; Treponema pallidum; secretion; fibrinogen; epithelial cells; bioinformatics; Prevotella intermedia; genes; signal peptide; fibroblasts; bacteria; Escherichia coli
Abstract:
... The oral bacterium Prevotella intermedia attaches to and invades gingival epithelial cells, fibroblasts, and endothelial cells. Several genes encoding proteins that mediate both the adhesion and invasion processes are carried on the genome of this bacterium. Here, we characterized one such protein, AdpC, belonging to the leucine-rich repeat (LRR) protein family. Bioinformatics analysis revealed th ...
DOI:
10.1128/IAI.00510-09
PubMed:
20308299
PubMed Central:
PMC2876575

50. Adsorbed Polyzwitterion Copolymer Layers Designed for Protein Repellency and Interfacial Retention

Author:
Kalasin S.; Letteri R. A.; Emrick T.; Santore M. M.
Source:
Langmuir 2017 v.33 no.47 pp. 13708-13717
ISSN:
1520-5827
Subject:
adsorption; brushes; composite polymers; fibrinogen; lysine; lysozyme; polyethylene glycol; polymerization
Abstract:
... Poly(2-methacryloyloxyethyl phosphorylcholine) (pMPC), when end-tethered to surfaces by the adsorption of copolymeric cationic segments, forms adsorbed layers that substantially reduce protein adsorption. This study examined variations in the molecular architecture of copolymers containing cationic poly(trimethylammonium ethyl methacrylate (pTMAEMA) anchor blocks that adsorbed strongly to negative ...
DOI:
10.1021/acs.langmuir.7b03391