Subject: humans / Subject term: humans and functional properties / Text availability: Citation in PubAg

1. Within‐ and Between‐Habitat Avian Diversity in African and Neotropical Lowland Habitats

Author:: James R. Karr
Source:: Ecological monographs 1976 v.46 no.4 pp. 457-481
ISSN:: 0012-9615
Subject:: Chiroptera; Neotropics; Pleistocene epoch; avifauna; birds; convergent evolution; dry season; flowers; forests; fruits; functional properties; geography; grasslands; habitats; humans; mountains; rivers; savannas; trophic relationships; weather; Liberia; Panama; South America
Abstract:: ... The general pattern of changes in avian communities along latitudinal, successional, or moisture gradients have been clarified in recent years. However, few studies have compared avifaunas of similar vegetation types and climates in two tropical regions. In this study I asked two questions. How similar ecologically are the avian communities in two tropical areas (Panama and Liberia) with similar c ...
DOI:: 10.2307/1942566
: https://doi.org/10.2307/1942566

2. Whey research

Author:: E. W. Evans
Source:: International journal of dairy technology 1980 v.33 no.3 pp. 95-100
ISSN:: 1364-727X
Subject:: digestive system; dough; fractionation; functional properties; humans; ion exchange; lactose; lactose intolerance; neonates; nutrient density; peroxidase; taint; whey; whey protein
Abstract:: ... The composition of whey is briefly discussed and less well‐known areas for research on whey are highlighted. On whole whey solids aspects of lactose intolerance and of whey taint require attention. Lactose derivatives, the flavour‐binding quality of lactose, and its precise behaviour in dough require sudy. A long‐shot application for binding fines in steelmaking forms the subject of an American sp ...
DOI:: 10.1111/j.1471-0307.1980.tb00002.x
: https://doi.org/10.1111/j.1471-0307.1980.tb00002.x

3. Identification and characterization of the mouse MutS homolog 5: Msh5

Author:: Chengtao Her; Xiling Wu; Wei Wan; Norman A. Doggett
Source:: Mammalian genome 1999 v.10 no.11 pp. 1054-1061
ISSN:: 0938-8990
Subject:: sequence analysis; messenger RNA; complementary DNA; chromosomes; humans; open reading frames; two hybrid system techniques; amino acid sequences; mice; Northern blotting; functional properties; testes; molecular weight; exons; introns
Abstract:: ... We have identified and characterized the complete cDNA and gene for the mouse MutS homolog 5 (Msh5), as a step toward understanding the molecular genetic mechanisms involved in the biological function of this new MutS homologous protein in mammals. The Msh5 cDNA contains a 2502-bp open reading frame (ORF) that encodes an 833-amino acid protein with a predicted molecular weight of 92.6 kDa, which s ...
DOI:: 10.1007/s003359901161
: https://doi.org/10.1007/s003359901161

4. Human oxytocin receptors in cholesterol‐rich vs. cholesterol‐poor microdomains of the plasma membrane

Author:: Gerald Gimpl; Falk Fahrenholz
Source:: European journal of biochemistry 2000 v.267 no.9 pp. 2483-2497
ISSN:: 0014-2956
Subject:: G-protein coupled receptors; agonists; cholesterol; fractionation; functional properties; green fluorescent protein; guanosine triphosphate; humans; oxytocin receptors; plasma membrane; solubilization
Abstract:: ... We analyzed the properties of a G protein‐coupled receptor localized in cholesterol‐poor vs. cholesterol‐rich microdomains of the plasma membrane. For this purpose, the human oxytocin receptor, which is very sensitive against alterations of the membrane cholesterol level, was stably expressed in HEK293 cells. To calculate the total number of receptors independent of ligand binding studies, the oxy ...
DOI:: 10.1046/j.1432-1327.2000.01280.x
: https://doi.org/10.1046/j.1432-1327.2000.01280.x

5. Overproduction of spinach betaine aldehyde dehydrogenase in Escherichia coli: Structural and functional properties of wild‐type, mutants and E. coli enzymes

Author:: Aran Incharoensakdi; Nobuyuki Matsuda; Takashi Hibino; Yu‐Ling Meng; Hiroshi Ishikawa; Akira Hara; Tohru Funaguma; Tetsuko Takabe; Teruhiro Takabe
Source:: European journal of biochemistry 2000 v.267 no.24 pp. 7015-7023
ISSN:: 0014-2956
Subject:: Escherichia coli; betaine; betaine-aldehyde dehydrogenase; choline; functional properties; humans; mutants; osmotolerance; oxidation; spinach; sugar beet; temperature
Abstract:: ... Betaine aldehyde dehydrogenase (BADH) catalyzes the last step in the synthesis of the osmoprotectant glycine betaine from choline. Although betaine aldehyde has been thought to be a specific substrate for BADH, recent studies have shown that human and sugar beet BADHs also catalyze the oxidation of ω‐aminoaldehydes. To characterize the kinetic and stability properties of spinach BADH, five kinds o ...
DOI:: 10.1046/j.1432-1327.2000.01797.x
: https://doi.org/10.1046/j.1432-1327.2000.01797.x

6. A Peptide Derived from Bovine β-Casein Modulates Functional Properties of Bone Marrow-Derived Macrophages from Germfree and Human Flora-Associated Mice

Author:: Sandré, Catherine; Gleizes, Aude; Forestier, Françoise; Gorges-Kergot, Roseline; Chilmonczyk, Stefan; Léonil, Joëlle; Moreau, Marie-Christiane; Labarre, Colette
Source:: Journal of nutrition 2001 v.131 no.11 pp. 2936-2942
ISSN:: 0022-3166
Subject:: antigens; antimicrobial properties; beta-casein; bioassays; bone marrow; cattle; enzyme-linked immunosorbent assay; flora; flow cytometry; functional properties; humans; immunomodulation; interleukin-12; interleukin-1beta; lipopolysaccharides; macrophage colony-stimulating factor; macrophages; major histocompatibility complex; messenger RNA; mice; phagocytosis; reverse transcriptase polymerase chain reaction; secretion; tumor necrosis factor-alpha
Abstract:: ... The purpose of this study was to evaluate the immunomodulatory activity of a peptide derived from bovine β-casein (β-CN), the β-CN (193-209) peptide, on mouse macrophages that were obtained either from germfree (GF) or from human flora-associated (HF) mice. Macrophages were derived from bone marrow (BMDM) in the presence of recombinant macrophage colony-stimulating factor and exposed to the peptid ...

7. Recent Molecular Advances in Mammalian Glutamine Transport

Author:: Bode, Barrie P.
Source:: Journal of nutrition 2001 v.131 no.9S pp. 2475S-2485S
ISSN:: 0022-3166
Subject:: amino acid transporters; cDNA libraries; complementary DNA; functional properties; genes; glutamine; humans; metabolism; plasma membrane; rodents; substrate specificity; tissue distribution
Abstract:: ... Much has been learned about plasma membrane glutamine transporter activities in health and disease over the past 30 years, including their potential regulatory role in metabolism. Since the 1960s, discrimination among individual glutamine transporters was based on functional characteristics such as substrate specificity, ion dependence, and kinetic and regulatory properties. Within the past two ye ...

8. The interaction of human apolipoprotein CâI with subâmicellar phospholipid

Author:: Benjamin W. Atcliffe; Christopher A. MacRaild; Paul R. Gooley; Geoffrey J. Howlett
Source:: European journal of biochemistry 2001 v.268 no.10 pp. 2838-2846
ISSN:: 0014-2956
Subject:: Escherichia coli; amino acids; apolipoprotein C-I; cholesteryl ester transfer protein; circular dichroism spectroscopy; crosslinking; egg yolk; functional properties; humans; micelles; nuclear magnetic resonance spectroscopy; phosphatidylcholines
Abstract:: ... Mature human apolipoprotein CâI (apoCâI), comprising 57 amino acids, is the smallest member of the plasma apolipoprotein family. Amphipathic helical regions within apoCâI, common to this class of proteins, are mediators of lipid binding, a process that underlies the functional properties of apoCâI, including the capacity to activate the plasma enzyme LCAT, to disrupt apoE mediated receptor ...
DOI:: 10.1046/j.1432-1327.2001.02164.x
: https://doi.org/10.1046/j.1432-1327.2001.02164.x

9. A functionally conserved member of the FTZâF1 nuclear receptor family from Schistosoma mansoni

Author:: Ricardo L de MendonÃ§a; Didier Bouton; Benjamin Bertin; Hector Escriva; Christophe NoÃ«l; JeanâMarc Vanacker; Jocelyne Cornette; Vincent Laudet; Raymond J. Pierce
Source:: European journal of biochemistry 2002 v.269 no.22 pp. 5700-5711
ISSN:: 0014-2956
Subject:: DNA-binding domains; Danio rerio; Drosophila; Schistosoma mansoni; adults; cercariae; exons; functional properties; humans; invertebrates; larvae; males; messenger RNA; miracidia; mutants; parasites; phylogeny; protein synthesis; receptors; reporter genes; sexual development; transcription (genetics)
Abstract:: ... The fushi tarazu factor 1 (FTZâF1) nuclear receptor subfamily comprises orphan receptors with crucial roles in development and sexual differentiation in vertebrates and invertebrates. We describe the structure and functional properties of an FTZâF1 from the platyhelminth parasite of humans, Schistosoma mansoni, the first receptor from this family to be characterized in a Lophotrochozoan. It co ...
DOI:: 10.1046/j.1432-1033.2002.03287.x
: https://doi.org/10.1046/j.1432-1033.2002.03287.x

10. Association of human tumor necrosis factor‐related apoptosis inducing ligand with membrane upon acidification

Author:: Gyu Hyun Nam; Kwan Yong Choi
Source:: European journal of biochemistry 2002 v.269 no.21 pp. 5280-5287
ISSN:: 0014-2956
Subject:: acidification; apoptosis; crystal structure; denaturation; fluorescence; functional properties; humans; hydrophobicity; lymphotoxin; necrosis; pH; phase transition; proteins; solvents; tryptophan; tumor necrosis factor-alpha; wavelengths
Abstract:: ... Tumor necrosis factor (TNF)‐related apoptosis inducing ligand (TRAIL) has been known to induce tumor‐specific apoptosis and to share the structural and functional characteristics with the proteins of TNF family. Recently, the crystal structure of human TRAIL showed that TRAIL is a homotrimeric protein whose subunits contain mainly β‐sheets. We characterized the structural changes of recombinant hu ...
DOI:: 10.1046/j.1432-1033.2002.03242.x
: https://doi.org/10.1046/j.1432-1033.2002.03242.x

11. Ferritin from the spleen of the Antarctic teleost Trematomus bernacchii is an Mâtype homopolymer

Author:: Guiseppina Mignogna; Roberta Chiaraluce; Valerio Consalvi; Stefano Cavallo; Simonetta Stefanini; Emilia Chiancone
Source:: European journal of biochemistry 2002 v.269 no.6 pp. 1600-1606
ISSN:: 0014-2956
Subject:: Oncorhynchus mykiss; Trematomus bernacchii; acclimation; activation energy; amino acid sequences; cold; denaturation; ferritin; ferroxidase; functional properties; humans; iron; micelles; spleen; temperature; Antarctic region
Abstract:: ... Ferritin from the spleen of the Antarctic teleost Trematomus bernacchii is composed of a single subunit that contains both the ferroxidase center residues, typical of mammalian Hâchains, and the carboxylate residues forming the micelle nucleation site, typical of mammalian Lâchains. Comparison of the aminoâacid sequence with those available from lower vertebrates indicates that T.âbernacch ...
DOI:: 10.1046/j.1432-1327.2002.02762.x
: https://doi.org/10.1046/j.1432-1327.2002.02762.x

12. Organization of six functional mouse alcohol dehydrogenase genes on two overlapping bacterial artificial chromosomes

Author:: Gabor Szalai; Gregg Duester; Robert Friedman; Honggui Jia; ShaoPing Lin; Bruce A. Roe; Michael R. Felder
Source:: European journal of biochemistry 2002 v.269 no.1 pp. 224-232
ISSN:: 0014-2956
Subject:: alcohol dehydrogenase; amino acid sequences; bacterial artificial chromosomes; clones; functional properties; gene expression regulation; humans; mice; multigene family; phylogeny; pseudogenes; sequence analysis; transcription (genetics)
Abstract:: ... Mammalian alcohol dehydrogenases (ADH) form a complex enzyme system based on amino‐acid sequence, functional properties, and gene expression pattern. At least four mouse Adh genes are known to encode different enzyme classes that share less than 60% amino‐acid sequence identity. Two ADH‐containing and overlapping C57BL/6 bacterial artificial chromosome clones, RP23‐393J8 and ‐463H24, were identifi ...
DOI:: 10.1046/j.0014-2956.2001.02642.x
: https://doi.org/10.1046/j.0014-2956.2001.02642.x

13. Development and comparison of in vivo and in vitro models for endometritis in cows and mares

Author:: Zerbe, H.; Schuberth, H.J.; Engelke, F.; Frank, J.; Klug, E.; Leibold, W.
Source:: Theriogenology 2003 v.60 no.2 pp. 209-223
ISSN:: 0093-691X
Subject:: cows; endometritis; functional properties; humans; in vitro studies; interleukin-8; mares; models; neutrophils; phenotype; reactive oxygen species; uterus
Abstract:: ... In order to investigate pathogenic mechanisms of acute endometritis in cows and mares, we established an in vivo model in both species. Based on the results of an in vitro transmigration system, human recombinant interleukin-8 (rhIL-8; 1.25μg per mare and 5μg per cow in 50ml phosphate-buffered saline) was used to attract polymorphonuclear neutrophil granulocytes (PMNs) into the uteri. Peak numbers ...

14. Kimchi and an Active Component, β-Sitosterol, Reduce Oncogenic H-Rasv12-Induced DNA Synthesis

Author:: Park, Kun-Young; Cho, Eun-Ju; Rhee, Sook-Hee; Jung, Keun-Ok; Yi, Sun-Ju; Jhun, Byung H.
Source:: Journal of medicinal food 2003 v.6 no.3 pp. 151-156
ISSN:: 1096-620X
Subject:: DNA; anticarcinogenic activity; beta-sitosterol; cabbage; fibroblasts; functional properties; gene overexpression; humans; insulin receptors; kimchi; methanol; methylene chloride; oncogenes; signal transduction
Abstract:: ... The Korean fermented vegetable food, kimchi, has been demonstrated to have anticancer functional properties. This study examined the effect of kimchi samples, methanol extracts of commercially grown baechu cabbage kimchi (CK) and organically grown baechu cabbage kimchi (OK), as well as the dichloromethane fraction (DCM fr.) from CK, and the active compound (AC), which has been identified as largel ...
DOI:: 10.1089/10966200360716544.
: https://doi.org/10.1089/10966200360716544.

15. Specificity and promiscuity of gonadotropin receptors

Author:: Costagliola, Sabine; Urizar, Eneko; Mendive, Fernando; Vassart, Gilbert
Source:: Reproduction 2005 v.130 no.3 pp. 275-281
ISSN:: 1470-1626
Subject:: G-proteins; follicle-stimulating hormone; follicle-stimulating hormone receptors; functional properties; glycoproteins; granulosa cells; human chorionic gonadotropin; humans; luteinizing hormone; mutation; pregnancy; serpentine; thyrotropin
Abstract:: ... The dichotomy between hormone recognition by the ectodomain and activation of the G protein by the rhodopsin-like serpentine portion is a well established property of glycoprotein hormone receptors. The specificity barrier avoiding promiscuous activation of the FSH receptor by the high concentration of human chorionic gonadotropin (hCG) prevailing during human pregnancy was thus believed to lie in ...
DOI:: 10.1530/rep.1.00662
PubMed:: 16123234
: https://doi.org/10.1530/rep.1.00662

16. Barley yellow dwarf viruses (BYDVs) preserved in herbarium specimens illuminate historical disease ecology of invasive and native grasses

Author:: MALMSTROM, CAROLYN M.; SHU, RUIJIE; LINTON, ERIC W.; NEWTON, LINSEY A.; COOK, MERIDITH A.
Source:: Journal of ecology 2007 v.95 no.6 pp. 1153-1166
ISSN:: 0022-0477
Subject:: Luteoviridae; RNA; barley; ecological invasion; ecosystems; functional properties; grasses; grasslands; herbaria; home range; horticulture; humans; indigenous species; invasive species; nucleotide sequences; pathogens; phylogeny; Australia; California
Abstract:: ... 1. In plant invasion ecology, viruses and other pathogens are often considered in terms of the enemy release hypothesis, which predicts that plants become invasive in new ranges if they escape pathogens from their home range. However, pathogens may sometimes facilitate host spread rather than hinder it. 2. Previously, we hypothesized that apparent competition mediated by barley and cereal yellow d ...
DOI:: 10.1111/j.1365-2745.2007.01307.x
: https://doi.org/10.1111/j.1365-2745.2007.01307.x

17. Differential structure and activity between human and mouse intelectin-1: Human intelectin-1 is a disulfide-linked trimer, whereas mouse homologue is a monomer

Author:: Tsuji, Shoutaro; Yamashita, Makiko; Nishiyama, Akihito; Shinohara, Tsutomu; Li, Zhongwei; Myrvik, Quentin N.; Hoffman, Donald R.; Henriksen, Ruth Ann; Shibata, Yoshimi
Source:: Glycobiology 2007 v.17 no.10 pp. 1045-1051
ISSN:: 0959-6658
Subject:: adsorption; amino acids; cell walls; functional properties; humans; intestines; lectins; mice; microorganisms; oligosaccharides; recombinant proteins; tissues; xylose
Abstract:: ... Human intelectin-1 (hITLN-1) is a 120-kDa lectin recognizing galactofuranosyl residues found in cell walls of various microorganisms but not in mammalian tissues. Although mouse intelectin-1 (mITLN-1) has been identified previously, its biochemical properties and functional characteristics have not been studied. Therefore, we have compared structures and saccharide-binding specificities of hITLN-1 ...
DOI:: 10.1093/glycob/cwm075
: https://doi.org/10.1093/glycob/cwm075

18. KBERG: KnowledgeBase for Estrogen Responsive Genes

Author:: Tang, Suisheng; Zhang, Zhuo; Tan, Sin Lam; Tang, Man-Hung Eric; Kumar, Arun Prashanth; Ramadoss, Suresh Kumar; Bajic, Vladimir B.
Source:: Nucleic acids research 2007 v.35 no.suppl_1 pp. D732
ISSN:: 0305-1048
Subject:: binding sites; evolution; expressed sequence tags; functional properties; genetic databases; human physiology; humans; mice; multigene family; nucleic acids; promoter regions; rats; transcription (genetics); transcription factors
Abstract:: ... Estrogen has a profound impact on human physiology affecting transcription of numerous genes. To decipher functional characteristics of estrogen responsive genes, we developed KnowledgeBase for Estrogen Responsive Genes (KBERG). Genes in KBERG were derived from Estrogen Responsive Gene Database (ERGDB) and were analyzed from multiple aspects. We explored the possible transcription regulation mecha ...

19. Shallow lakes, the water framework directive and life. What should it all be about

Author:: Moss, Brian
Source:: Hydrobiologia 2007 v.584 no.1 pp. 381-394
ISSN:: 0018-8158
Subject:: biodiversity; freshwater; functional properties; humans; lakes; nutrient availability; water quality; watersheds
Abstract:: ... The European Water Framework Directive offers an unprecedented opportunity for improvement of ecological quality of both freshwater and marine systems. It has implications for every aspect of how catchments are used by human societies and could potentially mean a step change in how waters and catchments are managed. It must be implemented, however, by official bodies, which seem likely to apply ec ...
DOI:: 10.1007/s10750-007-0601-1
: https://doi.org/10.1007/s10750-007-0601-1

20. Defining the functional properties of dietary protein and protein-rich foods in human energy expenditure

Author:: TAN, Sze Yen; TAPSELL, Linda; BATTERHAM, Marijka; CHARLTON, Karen
Source:: Nutrition & dietetics 2008 v.65 no.s3 pp. S66
ISSN:: 1446-6368
Subject:: calorimeters; dietary protein; energy intake; functional properties; high protein diet; high protein foods; humans; nutritional intervention; omnivores; thermic effect of food; vegetarian diet; weight loss
Abstract:: ... Food has a number of functional properties that can support the balance between energy intake and energy expenditure and, theoretically, one of these is the thermic effect of food. Including high-protein foods in meals may be advantageous in contributing to energy expenditure but, in practice, the evidence needs to relate to specific foods and normal dietary conditions. Using the human whole room ...
DOI:: 10.1111/j.1747-0080.2008.00264.x
: https://doi.org/10.1111/j.1747-0080.2008.00264.x

21. Generation of glyco-engineered Nicotiana benthamiana for the production of monoclonal antibodies with a homogeneous human-like N-glycan structure

Author:: Strasser, Richard; Stadlmann, Johannes; Schähs, Matthias; Stiegler, Gabriela; Quendler, Heribert; Mach, Lukas; Glössl, Josef; Weterings, Koen; Pabst, Martin; Steinkellner, Herta
Source:: Plant biotechnology journal 2008 v.6 no.4 pp. 392-402
ISSN:: 1467-7644
Subject:: neutralization; RNA interference; phenotype; antigens; humans; Human immunodeficiency virus; electrophoresis; Nicotiana benthamiana; biopharmaceuticals; glycosylation; recombinant proteins; xylose; monoclonal antibodies; genes; mutants; functional properties; Chinese hamsters; animal ovaries; glycoproteins
Abstract:: ... A common argument against using plants as a production system for therapeutic proteins is their inability to perform authentic human N-glycosylation (i.e. the presence of β1,2-xylosylation and core α1,3-fucosylation). In this study, RNA interference (RNAi) technology was used to obtain a targeted down-regulation of the endogenous β1,2-xylosyltransferase (XylT) and α1,3-fucosyltransferase (FucT) ge ...
DOI:: 10.1111/j.1467-7652.2008.00330.x
PubMed:: 18346095
: https://doi.org/10.1111/j.1467-7652.2008.00330.x

22. Polymorphisms in the kappa casein (CSN3) gene in horse and comparative analysis of its promoter and coding region

Author:: Hobor, S.; Kunej, T.; Dovc, P.
Source:: Animal genetics 2008 v.39 no.5 pp. 520-530
ISSN:: 0268-9146
Subject:: kappa-casein; sequence alignment; goats; zebras; cows; gel electrophoresis; promoter regions; horse breeds; genotype; genotyping; restriction fragment length polymorphism; transcription factors; humans; polymerase chain reaction; amino acid sequences; exons; single nucleotide polymorphism; sheep; amino acid substitution; asses; binding sites; genomics; functional properties; horses
Abstract:: ... The major parts of the coding region and promoter of the equine kappa casein (CSN3) gene were sequenced and compared among several species. Four SNPs were identified in the CSN3 gene: two in exon 1 and two in exon 4. The SNPs were genotyped in six Slovenian horse breeds using RFLP and two different PCR-based methods. The highest variation in genotype frequencies was found in the Slovenian cold-blo ...
DOI:: 10.1111/j.1365-2052.2008.01764.x
PubMed:: 18752583
: https://doi.org/10.1111/j.1365-2052.2008.01764.x

23. Characteristics and Nutritional and Cardiovascular-Health Properties of Seaweeds

Author:: Bocanegra, Aránzazu; Bastida, Sara; Benedi, Juana; Rodenas, Sofia; Sánchez-Muniz, Francisco J.
Source:: Journal of medicinal food 2009 v.12 no.2 pp. 236-258
ISSN:: 1096-620X
Subject:: nutrient content; algae; vitamins; blood pressure; health foods; energy content; edible seaweed; mineral content; dietary fiber; humans; phytochemicals; body weight; lipid metabolism; antioxidant activity; weight gain; nutrient availability; nutritive value; functional properties; polyunsaturated fatty acids; dietary minerals
DOI:: 10.1089/jmf.2008.0151
PubMed:: 19459725
: https://doi.org/10.1089/jmf.2008.0151

24. Design and humanization of a murine scFv that blocks human platelet glycoprotein VI in vitro

Author:: Muzard, Julien; Bouabdelli, Maxime; Zahid, Muhammad; Ollivier, Véronique; Lacapère, Jean Jacques; Jandrot-Perrus, Martine; Billiald, Philippe
Source:: FEBS journal 2009 v.276 no.15 pp. 4207-4222
ISSN:: 1742-464X
Subject:: adhesion; antibodies; bacteria; blood platelets; blood vessels; cell adhesion; collagen; functional properties; glycoproteins; hemorrhage; humans; immunoglobulin G; mice; models; platelet aggregation
Abstract:: ... Platelet adhesion and aggregation at the site of vascular injury is essential for hemostasis, but can also lead to arterial occlusion in thrombotic disorders. Glycoprotein (GP) VI is the major platelet membrane receptor that interacts directly with collagen, the most thrombogenic compound in the blood vessels. GPVI could therefore be a major therapeutic target. Fab fragments of the anti-GPVI murin ...
DOI:: 10.1111/j.1742-4658.2009.07129.x
PubMed:: 19558491
: https://doi.org/10.1111/j.1742-4658.2009.07129.x

25. Evolutionary changes to transthyretin: structure-function relationships

Author:: Prapunpoj, P.; Leelawatwattana, L.
Source:: FEBS journal 2009 v.276 no.19 pp. 5330-5341
ISSN:: 1742-464X
Subject:: X-ray diffraction; amyloidosis; cerebrospinal fluid; evolution; functional properties; human diseases; humans; metabolism; mice; phenotype; prealbumin; retinol-binding protein; structure-activity relationships; thyroid hormones; vitamin A
Abstract:: ... Transthyretin is one of the three major thyroid hormone-binding proteins in plasma and/or cerebrospinal fluid of vertebrates. It transports retinol via binding to retinol-binding protein, and exists mainly as a homotetrameric protein of ~ 55 kDa in plasma. The first 3D structure of transthyretin was an X-ray crystal structure from human transthyretin. Elucidation of the structure-function relation ...
DOI:: 10.1111/j.1742-4658.2009.07243.x
PubMed:: 19725883
: https://doi.org/10.1111/j.1742-4658.2009.07243.x

26. Individual and combined action of pancreatic lipase and pancreatic lipase-related proteins 1 and 2 on native versus homogenized milk fat globules

Author:: Berton, Amélie; Sebban-Kreuzer, Corinne; Rouvellac, Stéphanie; Lopez, Christelle; Crenon, Isabelle
Source:: Molecular nutrition & food research 2009 v.53 no.12 pp. 1592-1602
ISSN:: 1613-4125
Subject:: bile salts; digestion; fat globules; fatty acids; functional properties; homogenized milk; humans; hydrolysis; low fat milk; milk fat; neonates; proteins; proteolysis; triacylglycerol lipase
Abstract:: ... Pancreatic lipase (PL) and pancreatic lipase-related proteins 1 and 2 (PLRP1 and PLRP2) display different functional properties, despite close structures. The aim of the study was to compare the kinetic properties of recombinant human PLRP1, PLRP2, and PL on a physiological substrate: the milk fat under native and homogenized structures. No lipolytic activity is measured for PLRP1. PLRP2 hydrolyse ...
DOI:: 10.1002/mnfr.200800563
PubMed:: 19824014
: https://doi.org/10.1002/mnfr.200800563

27. Influence of conjugated linoleic acids on functional properties of vascular cells

Author:: Ringseis, Robert; Eder, Klaus
Source:: British journal of nutrition 2009 v.102 no.8 pp. 1099-1116
ISSN:: 0007-1145
Subject:: anti-inflammatory activity; atherosclerosis; humans; disease prevention; inflammation; cytokines; cells; blood vessels; functional properties; conjugated linoleic acid; protective effect
Abstract:: ... Conjugated linoleic acids (CLA) are biologically highly active lipid compounds that inhibit the development of atherosclerotic plaques in experimental animals. The underlying mechanisms of action, however, are only poorly understood. Since cell-culture experiments are appropriate to provide a detailed view into the mechanisms of action of a compound, the present review summarises results from in v ...
DOI:: 10.1017/S0007114509990304
PubMed:: 19622186
: https://doi.org/10.1017/S0007114509990304

28. Interleukin-1-inducible MCPIP protein has structural and functional properties of RNase and participates in degradation of IL-1β mRNA

Author:: Mizgalska, Danuta; Węgrzyn, Paulina; Murzyn, Krzysztof; Kasza, Aneta; Koj, Aleksander; Jura, Jacek; Jarząb, Barbara; Jura, Jolanta
Source:: FEBS journal 2009 v.276 no.24 pp. 7386-7399
ISSN:: 1742-464X
Subject:: actinomycin D; amino acids; bioinformatics; chemoattractants; functional properties; gene expression; genes; half life; humans; interleukin-12; interleukin-1beta; interleukin-6; macrophages; messenger RNA; monocytes; mutants; point mutation; precipitin tests; ribonucleases
Abstract:: ... In human monocyte-derived macrophages, the MCPIP gene (monocyte chemoattractant protein-induced protein) is strongly activated by interleukin-1β (IL-1β). Using bioinformatics, a PIN domain was identified, spanning amino acids 130-280; such domains are known to possess structural features of RNases. Recently, RNase properties of MCPIP were confirmed on transcripts coding for interleukins IL-6 and I ...
DOI:: 10.1111/j.1742-4658.2009.07452.x
: https://doi.org/10.1111/j.1742-4658.2009.07452.x

29. Physicochemical Properties of β-Glucan in Differently Processed Oat Foods Influence Glycemic Response

Author:: Regand, Alejandra; Tosh, Susan M.; Wolever, Thomas M.S.; Wood, Peter J.
Source:: Journal of agricultural and food chemistry 2009 v.57 no.19 pp. 8831–8838
ISSN:: 0021-8561
Subject:: chemical concentration; depolymerization; oat products; foods; humans; viscosity; glycemic effect; blood glucose; food processing; postprandial state; functional properties; molecular weight; beta-glucans
Abstract:: ... To assess the effect of food processing on the capacity of oat β-glucan to attenuate postprandial glycemia, isocaloric crisp bread, granola, porridge, and pasta containing 4 g of β-glucan as well as control products with low β-glucan content were prepared. The physicochemical properties (viscosity, peak molecular weight (Mp), and concentration (C)) of β-glucan in in-vitro-digestion extracts were e ...
DOI:: 10.1021/jf901271v
: https://doi.org/10.1021/jf901271v

30. Safety and Functional Aspects of Preselected Enterococci for Probiotic Use in Iberian Dry-Fermented Sausages

Author:: Ruiz-Moyano, Santiago; Martín, Alberto; Benito, María José; Aranda, Emilio; Casquete, Rocío; Córdoba, María de Guía
Source:: Journal of food science 2009 v.74 no.7 pp. M398
ISSN:: 0022-1147
Subject:: dried meat; traditional foods; cell adhesion; functional properties; fermented foods; feces; Listeria monocytogenes; virulence; antimicrobial properties; humans; Enterococcus faecium; strain differences; hemolysis; food safety; swine; antibiotic resistance; probiotics; food pathogens; sausages; biogenic amines; Spain
Abstract:: ... The purpose of this study was to investigate enterococci for potential probiotic use in Iberian dry-fermented sausages. A total of 15 strains isolated from Iberian dry-fermented sausages, human feces, and pig feces were evaluated for their safety and functional characteristics including biogenic amine (BA) production, antibiotic susceptibility, hemolysis, virulence determinants, cell adhesion, and ...
DOI:: 10.1111/j.1750-3841.2009.01290.x
PubMed:: 19895487
: https://doi.org/10.1111/j.1750-3841.2009.01290.x

31. A simple method of surface functionalisation for immuno-specific immobilisation of proteins

Author:: Kengne-Momo, R. P.; Jeyachandran, Y. L.; Assaf, A.; Esnault, C.; Daniel, P.; Pilard, J. F.; Durand, M. J.; Lagarde, F.; Dongo, E.; Thouand, G.
Source:: Analytical and bioanalytical chemistry 2010 v.398 no.3 pp. 1249-1255
ISSN:: 1618-2642
Subject:: Raman spectroscopy; electrochemistry; functional properties; gold; humans; immunoglobulin G; quartz
Abstract:: ... We present a new and advanced methodology, developed for surface functionalisation of gold and to study immobilisation of an immuno-specific system of proteins. A combination of electrochemical quartz crystal microbalance and Raman spectroscopy techniques allowed a complete understanding of the system starting from surface functionalisation and progressing to the functional structure analysis of i ...
DOI:: 10.1007/s00216-010-4032-x
PubMed:: 20683585
: https://doi.org/10.1007/s00216-010-4032-x

32. CLERC and centrosomal leucine-rich repeat proteins

Author:: Yoshinori Muto; Yukio Okano
Source:: Open life sciences 2010 v.5 no.1 pp. 1-10
ISSN:: 2391-5412
Subject:: Chlamydomonas; centrosomes; databases; functional properties; humans; mitosis; proteins; proteome
Abstract:: ... The centrosome functions as the microtubule-organizing center and plays a vital role in organizing spindle poles during mitosis. Recently, we identified a centrosomal protein called CLERC (Centrosomal leucine-rich repeat and coiled-coil containing protein) which is a human ortholog of Chlamydomonas Vfl1 protein. The bibliography as well as database searches provided evidence that the human proteom ...
DOI:: 10.2478/s11535-009-0061-x
: https://doi.org/10.2478/s11535-009-0061-x

33. Effect of Lime and Wood Ash on the Nixtamalization of Maize and Tortilla Chemical and Nutritional Characteristics

Author:: Pappa, María Renée; de Palomo, Patricia Palacios; Bressani, Ricardo
Source:: Plant foods for human nutrition 2010 v.65 no.2 pp. 130-135
ISSN:: 0921-9668
Subject:: calcium; color; cooking; corn; functional properties; hardness; humans; iron; magnesium; masa; minerals; nixtamalization; pH; potassium; protein value; sensory evaluation; sensory properties; soaking; tortillas; water content; wood; wood ash; zinc
Abstract:: ... The objective of the study was to obtain information on the chemical composition, functional properties, sensory quality and protein value of tortillas made from the nixtamalization of maize using either lime or wood ashes. The Ca, K, Mg, Fe, and Zn content of lime and wood ashes showed lime to be high in Ca content while wood ash contained more K and about 71% of the Ca content of lime. Both cont ...
DOI:: 10.1007/s11130-010-0162-8
PubMed:: 20369297
: https://doi.org/10.1007/s11130-010-0162-8

34. Ovine bone marrow mesenchymal stem cells: isolation and characterization of the cells and their osteogenic differentiation potential on embroidered and surface-modified polycaprolactone-co-lactide scaffolds

Author:: Rentsch, C.; Hess, R.; Rentsch, B.; Hofmann, A.; Manthey, S.; Scharnweber, D.; Biewener, A.; Zwipp, H.
Source:: In vitro cellular & developmental biology 2010 v.46 no.7 pp. 624-634
ISSN:: 1071-2690
Subject:: Merino; bone formation; bone marrow; cell movement; chondroitin sulfate; coatings; collagen; functional properties; humans; mathematical models; sheep; stem cells; therapeutics
Abstract:: ... The current study was undertaken with the goal being isolation, cultivation, and characterization of ovine mesenchymal stem cells (oMSC). Furthermore, the objective was to determine whether biological active polycaprolactone-co-lactide (trade name PCL) scaffolds support the growth and differentiation of oMSC in vitro. The oMSC were isolated from the iliac crest of six merino sheep. Three factors w ...
DOI:: 10.1007/s11626-010-9316-0
: https://doi.org/10.1007/s11626-010-9316-0

35. Protein folding and aggregation in bacteria

Author:: Sabate, Raimon; de Groot, Natalia S.; Ventura, Salvador
Source:: Cellular and molecular life sciences 2010 v.67 no.16 pp. 2695-2715
ISSN:: 1420-682X
Subject:: adhesion; amyloid; bacteria; bedrock; cytotoxicity; functional properties; humans; inclusion bodies; neurodegenerative diseases; polypeptides; protein folding; ribosomes; transcription (genetics)
Abstract:: ... Proteins might experience many conformational changes and interactions during their lifetimes, from their synthesis at ribosomes to their controlled degradation. Because, in most cases, only folded proteins are functional, protein folding in bacteria is tightly controlled genetically, transcriptionally, and at the protein sequence level. In addition, important cellular machinery assists the foldin ...
DOI:: 10.1007/s00018-010-0344-4
PubMed:: 20358253
: https://doi.org/10.1007/s00018-010-0344-4

36. Schwann-like cells can be induction from human nestin-positive amniotic fluid mesenchymal stem cells

Author:: Jiang, Tai-Mao; Yang, Zhi-Jun; Kong, Chui-Ze; Zhang, Hong-Tian
Source:: In vitro cellular & developmental biology 2010 v.46 no.9 pp. 793-800
ISSN:: 1071-2690
Subject:: Schwann cells; Western blotting; amniotic fluid; coculture; functional properties; ganglia; growth factors; humans; nervous system diseases; neurons; stem cells; therapeutics
Abstract:: ... We examined the morphological, phenotypic, and functional characteristics of human amniotic fluid mesenchymal stem cells (AF-MSCs) differentiated towards a Schwann cell lineage. Initially, we induced human AF-MSCs into nestin-positive AF-MSCs. And then, these nestin-positive AF-MSCs were induced into floating neurospheres. After that, neurospheres were induced to differentiate into Schwann-like ce ...
DOI:: 10.1007/s11626-010-9335-x
: https://doi.org/10.1007/s11626-010-9335-x

37. Structural and Functional Alterations of Subcutaneous Small Resistance Arteries in Severe Human Obesity

Author:: Grassi, Guido; Seravalle, Gino; Scopelliti, Francesco; Dell'Oro, Raffaella; Fattori, Luca; Quarti-Trevano, Fosca; Brambilla, Gianmaria; Schiffrin, Ernesto L.; Mancia, Giuseppe
Source:: Obesity 2010 v.18 no.1 pp. 92-98
ISSN:: 1930-7381
Subject:: arteries; blood pressure; body mass index; functional properties; glucose; humans; insulin resistance; obesity; people; risk; vasodilation
Abstract:: ... Obese persons are at increased cardiovascular risk and exhibit increased arterial stiffness and impaired endothelial function of large- and medium-size arteries. We hypothesized that normotensive subjects suffering from severe obesity would also present remodeling and endothelial dysfunction of small resistance arteries. A total of 16 lean (age: 49.6 ± 2.9 years, BMI: 22.9 ± 0.3 kg/m2, mean ± s.e. ...
DOI:: 10.1038/oby.2009.195
: https://doi.org/10.1038/oby.2009.195

38. The cytotoxic effect of Bowman-Birk isoinhibitors, IBB1 and IBBD2, from soybean (Glycine max) on HT29 human colorectal cancer cells is related to their intrinsic ability to inhibit serine proteases

Author:: Clemente, Alfonso; Moreno, Francisco Javier; Marín-Manzano, Maria del Carmen; Jiménez, Elisabeth; Domoney, Claire
Source:: Molecular nutrition & food research 2010 v.54 no.3 pp. 396-405
ISSN:: 1613-4125
Subject:: carcinogenesis; Bowman-Birk inhibitor; Glycine max; trypsin; cell growth; humans; soy protein; cytotoxicity; chymotrypsin; soybeans; amino acid sequences; cell proliferation; functional properties; colorectal neoplasms; cell cycle; colon
Abstract:: ... Bowman-Birk inhibitors (BBI) from soybean and related proteins are naturally occurring protease inhibitors with potential health-promoting properties within the gastrointestinal tract. In this work, we have investigated the effects of soybean BBI proteins on HT29 colon adenocarcinoma cells, compared with non-malignant colonic fibroblast CCD-18Co cells. Two major soybean isoinhibitors, IBB1 and IBB ...
DOI:: 10.1002/mnfr.200900122
PubMed:: 19885848
: https://doi.org/10.1002/mnfr.200900122

39. CD11c⁺ Cells are Significantly Decreased in the Duodenum, Ileum and Colon of Dogs with Inflammatory Bowel Disease

Author:: A. Kathrani; S. Schmitz; S.L. Priestnall; K.C. Smith; D. Werling; O.A. Garden; K. Allenspach
Source:: Journal of comparative pathology 2011 v.145 no.4 pp. 359-366
ISSN:: 0021-9975
Subject:: Beagle; biopsy; colon; dendritic cells; dogs; duodenum; fluorescence microscopy; functional properties; guidelines; humans; ileum; inflammation; inflammatory bowel disease; mice; monoclonal antibodies
Abstract:: ... CD11c serves as a marker for human and murine dendritic cells (DCs) and cells expressing this marker have been shown to have similar morphological and functional characteristics in the canine immune system. The aim of this study was to quantify CD11c⁺ cells in the duodenum, ileum and colon of healthy dogs and dogs with inflammatory bowel disease (IBD). Endoscopic biopsies from the duodenum (n=12 c ...
DOI:: 10.1016/j.jcpa.2011.03.010
PubMed:: 21592490
: https://doi.org/10.1016/j.jcpa.2011.03.010

40. Diversity of human skeletal muscle in health and disease: Contribution of proteomics

Author:: Cecilia Gelfi; Michele Vasso; Paolo Cerretelli
Source:: Journal of proteomics 2011 v.74 no.6 pp. 774-795
ISSN:: 1874-3919
Subject:: actin; animal models; biomarkers; cold; enzymes; exercise; functional properties; humans; hypoxia; insulin resistance; muscles; myosin; myositis; patients; proteome; proteomics; skeletal muscle; tropomyosins
Abstract:: ... Muscle represents a large fraction of the human body mass. It is an extremely heterogeneous tissue featuring in its contractile structure various proportions of heavy- and light-chain slow type 1 and fast types 2A and 2X myosins, actins, tropomyosins, and troponin complexes as well as metabolic proteins (enzymes and most of the players of the so-called excitation–transcription coupling). Muscle is ...
DOI:: 10.1016/j.jprot.2011.02.028
PubMed:: 21414428
: https://doi.org/10.1016/j.jprot.2011.02.028

41. Effect of divalent cations on the porcine kidney cortex membrane-bound form of dipeptidyl peptidase IV

Author:: Isel Pascual; Hansel Gómez; Tirso Pons; Mae Chappé; Miguel Angel Vargas; Gilberto Valdés; Alí Lopéz; Angélika Saroyán; Jean-Louis Charli; María de los Angeles Chávez
Source:: international journal of biochemistry & cell biology 2011 v.43 no.3 pp. 363-371
ISSN:: 1357-2725
Subject:: bacitracin; binding sites; bioinformatics; cadmium; calcium; cations; cell biology; cobalt; cortex; dipeptidyl-peptidase IV; functional properties; humans; kidneys; mechanism of action; mercury; noninsulin-dependent diabetes mellitus; swine; zinc
Abstract:: ... Dipeptidyl peptidase IV is an ectopeptidase with multiple physiological roles including the degradation of incretins, and a target of therapies for type 2 diabetes mellitus. Divalent cations can inhibit its activity, but there has been little effort to understand how they act. The intact membrane-bound form of porcine kidney dipeptidyl peptidase IV was purified by a simple and fast procedure. The ...
DOI:: 10.1016/j.biocel.2010.11.006
: https://doi.org/10.1016/j.biocel.2010.11.006

42. Electron microscopy morphology of the mitochondrial network in gliomas and their vascular microenvironment

Author:: Gabriel Arismendi-Morillo
Source:: Biochimica et biophysica acta 2011 v.1807 no.6 pp. 602-608
ISSN:: 0005-2728
Subject:: brain; electron microscopy; fatty-acid synthase; functional properties; glycolysis; humans; hypoxia-inducible factor 1; oxidative phosphorylation; patients; phenotype; pro-apoptotic proteins; prognosis; protein isoforms; therapeutics
Abstract:: ... Gliomas still represent a serious and discouraging brain tumor; despite of the diversity of therapeutic modalities, the prognosis for patients is still poor. Understanding the structural and functional characteristics of the vascular microenvironment in gliomas is essential for the design of future therapeutic strategies. This review describes and analyzes the electron microscopy morphology of the ...
DOI:: 10.1016/j.bbabio.2010.11.001
: https://doi.org/10.1016/j.bbabio.2010.11.001

43. Enzymatic hydrolysis of soy proteins and the hydrolysates utilisation

Author:: Xiang Dong Sun
Source:: International journal of food science & technology 2011 v.46 no.12 pp. 2447-2459
ISSN:: 0950-5423
Subject:: coagulation; immobilized enzymes; peptides; adenosine monophosphate; monosodium glutamate; flavor enhancers; amino acids; ingredients; functional foods; humans; protein sources; livestock; production costs; hydrolysis; high pressure treatment; antioxidant activity; glycosides; hydrolysates; taste; bitterness; soy protein; enzymatic hydrolysis; protein hydrolysates; functional properties
Abstract:: ... Soy proteins are very important protein source for human being and livestock. Enzymatic hydrolysis of soy protein can enhance or reduce its functional properties and improve its nutritious value. Soy protein hydrolysates were primarily used as functional food ingredients, flavour and nutritious enhancers, protein substitute, and clinical products. Conditions for hydrolysis were usually mild, where ...
DOI:: 10.1111/j.1365-2621.2011.02785.x
: https://doi.org/10.1111/j.1365-2621.2011.02785.x

44. Expressed sequence identification and characterization of the cDNA for Interleukin-4 from the mitogen-stimulated lymphoid tissue of a marsupial, Macropus eugenii

Author:: Lauren Young
Source:: Veterinary immunology and immunopathology 2011 v.140 no.3-4 pp. 335-340
ISSN:: 0165-2427
Subject:: chickens; messenger RNA; complementary DNA; T-lymphocytes; humans; rapid amplification of cDNA ends; amino acids; genes; nucleotide sequences; signal peptide; Macropus eugenii; species diversity; opossums; lymph nodes; interleukin-4; functional properties
Abstract:: ... Very few cytokines that are important to the understanding of T helper cell function are characterized in marsupials. Expression of a 645bp cDNA product that codes for a predicted Interleukin-4 peptide of 157 amino acids was detected in the lymph node tissues of Macropus eugenii, the tammar wallaby. Using Rapid Amplification of cDNA Ends, both 5′- and 3′-untranslated regions were identified and a ...
DOI:: 10.1016/j.vetimm.2010.12.006
PubMed:: 21196053
: https://doi.org/10.1016/j.vetimm.2010.12.006

45. Human hepatocytes and endothelial cells in organotypic membrane systems

Author:: Simona Salerno; Carla Campana; Sabrina Morelli; Enrico Drioli; Loredana De Bartolo
Source:: Biomaterials 2011 v.32 no.34 pp. 8848-8859
ISSN:: 0142-9612
Subject:: albumins; artificial membranes; biodegradability; chitosan; coculture; functional properties; hepatocytes; human umbilical vein endothelial cells; humans; liver; models; pharmacokinetics; phenotype; polyurethanes; secretion; tissue engineering; tissues; urea
Abstract:: ... The realization of organotypic liver model that exhibits stable phenotype is a major challenge in the field of liver tissue engineering. In this study we developed liver organotypic co-culture systems by using synthetic and biodegradable membranes with primary human hepatocytes and human umbilical vein endothelial cells (HUVEC). Synthetic membranes prepared by a polymeric blend constituted of modi ...
DOI:: 10.1016/j.biomaterials.2011.08.004
: https://doi.org/10.1016/j.biomaterials.2011.08.004

46. In Vitro Fermentation by Human Gut Bacteria of Proteolytically Digested Caseinomacropeptide Nonenzymatically Glycosylated with Prebiotic Carbohydrates

Author:: Hernandez-Hernandez, Oswaldo; Sanz, M. Luz; Kolida, Sofia; Rastall, Robert A.; Moreno, F. Javier
Source:: Journal of agricultural and food chemistry 2011 v.59 no.22 pp. 11949-11955
ISSN:: 0021-8561
Subject:: Atopobium; Bacteroides; Clostridium histolyticum; Maillard reaction; anaerobic conditions; bacteria; digestive system; feces; fermentation; functional properties; galactooligosaccharides; human health; humans; lactic acid; lactose; prebiotics; short chain fatty acids
Abstract:: ... The in vitro fermentation selectivity of hydrolyzed caseinomacropeptide (CMP) glycosylated, via Maillard reaction (MR), with lactulose, galacto-oligosaccharides from lactose (GOSLa), and galacto-oligosaccharides from lactulose (GOSLu) was evaluated, using pH-controlled small-scale batch cultures at 37 °C under anaerobic conditions with human feces. After 10 and 24 h of fermentation, neoglyconjugat ...
DOI:: 10.1021/jf203576g
PubMed:: 22004447
: https://doi.org/10.1021/jf203576g

47. In-vitro culture of Plasmodium falciparum: Utility of modified (RPNI) medium for drug-sensitivity studies using SYBR Green I assay

Author:: Shubhra Singh; Rajeev Kumar Srivastava; Mukesh Srivastava; S.K. Puri; K. Srivastava
Source:: Experimental parasitology 2011 v.127 no.1 pp. 318-321
ISSN:: 0014-4894
Subject:: Plasmodium falciparum; antimalarials; blood serum; drugs; functional properties; humans; hypoxanthine; inhibitory concentration 50; parasites; parasitology
Abstract:: ... Studies were carried out to establish the potential of RPNI medium for drug-sensitivity studies using the MSF assay. The drug sensitivity of standard anti-malarials was compared using both the (³H) Hypoxanthine incorporation assay and the MSF assay. The media supplements used during the study have been human serum, FBS and ALBUMAX-II. Drug sensitivity of two parasite lines, adapted to grow separat ...
DOI:: 10.1016/j.exppara.2010.08.007
: https://doi.org/10.1016/j.exppara.2010.08.007

48. Matrigel improves functional properties of human submandibular salivary gland cell line

Author:: Ola M. Maria; Osama Maria; Younan Liu; Svetlana V. Komarova; Simon D. Tran
Source:: international journal of biochemistry & cell biology 2011 v.43 no.4 pp. 622-631
ISSN:: 1357-2725
Subject:: alpha-amylase; apoptosis; biomarkers; cell proliferation; electrical resistance; fluorescent antibody technique; functional properties; humans; immunohistochemistry; messenger RNA; models; neoplasms; occludins; radiotherapy; salivary glands; secretion; stem cells; tight junctions; tissue engineering; tissue repair; transmission electron microscopy; vimentin
Abstract:: ... Sjogren's syndrome and radiotherapy for head and neck cancers result in irreversible damage to functional salivary tissue, for which no adequate treatment is available. The microenvironment for salivary gland cell cytodifferentiation is critical for the future development of salivary gland regeneration, repair and tissue engineering treatments. Results from this study indicate that human submandib ...
DOI:: 10.1016/j.biocel.2011.01.001
: https://doi.org/10.1016/j.biocel.2011.01.001

49. Mesenchymal stem cell like (MSCl) cells generated from human embryonic stem cells support pluripotent cell growth

Author:: Nóra Varga; Zoltán Veréb; Éva Rajnavölgyi; Katalin Német; Ferenc Uher; Balázs Sarkadi; Ágota Apáti
Source:: Biochemical and biophysical research communications 2011 v.414 no.3 pp. 474-480
ISSN:: 0006-291X
Subject:: cell growth; embryonic stem cells; fluorescent proteins; functional properties; humans; lymphocyte proliferation
Abstract:: ... Mesenchymal stem cell like (MSCl) cells were generated from human embryonic stem cells (hESC) through embryoid body formation, and isolated by adherence to plastic surface. MSCl cell lines could be propagated without changes in morphological or functional characteristics for more than 15 passages. These cells, as well as their fluorescent protein expressing stable derivatives, efficiently supporte ...
DOI:: 10.1016/j.bbrc.2011.09.089
: https://doi.org/10.1016/j.bbrc.2011.09.089

50. Partial inactivation of CCR5- and CXCR4- tropic HIV-1 by human urine

Author:: Bertran Auvert; Mohammad-Ali Jenabian; Héla Saidi; Pascale Lissouba; Laurent Bélec
Source:: Archives of virology 2011 v.156 no.12 pp. 2181-2186
ISSN:: 0304-8608
Subject:: HIV infections; T-lymphocytes; adsorption; dendritic cells; epithelial cells; functional properties; humans; models; pathogenicity; physiological transport; risk; urine
Abstract:: ... Human urine has been poorly investigated with regard to infection with human immunodeficiency virus (HIV). Here, we have studied the anti-infective functional properties of human urine against HIV. The effect of fresh urine pools on CCR5- and CXCR4-tropic HIV-1 was evaluated by using four in vitro mucosal models: reduction of infectivity of urine-treated HIV-1 particles, HIV-1 attachment to immatu ...
DOI:: 10.1007/s00705-011-1114-9
PubMed:: 21947506
: https://doi.org/10.1007/s00705-011-1114-9

51. Phytochemical profile, antioxidant, anti-inflammatory and hypoglycemic potential of hydroalcoholic extracts from Citrus medica L. cv Diamante flowers, leaves and fruits at two maturity stages

Author:: Federica Menichini; Monica R. Loizzo; Marco Bonesi; Filomena Conforti; Damiano De Luca; Giancarlo A. Statti; Bruno de Cindio; Francesco Menichini; Rosa Tundis
Source:: Food and chemical toxicology 2011 v.49 no.7 pp. 1549-1555
ISSN:: 0278-6915
Subject:: Citrus medica; alpha-amylase; anti-inflammatory activity; antioxidant activity; antioxidants; beta-carotene; bleaching; chemical composition; endocarp; fibroblasts; flavonoids; flowers; food quality; functional foods; functional properties; humans; inhibitory concentration 50; leaves; mesocarp; phenols; phytopharmaceuticals
Abstract:: ... Since the past decade consumption of certain foods has been reported to have a positive effect on health. The object of the study was to determine for the first time the chemical composition and the antioxidant, anti-inflammatory and hypoglycemic potential of Citrus medica L. cv Diamante flowers, leaves and fruits (endocarp and mesocarp) at two maturity stages. Flowers and leaves were characterize ...
DOI:: 10.1016/j.fct.2011.03.048
: https://doi.org/10.1016/j.fct.2011.03.048

52. Process optimization for chicken patties manufactured with a combination of spent hen and rabbit meat

Author:: Pawar, V.D.; Karthikeyan, B.; Zanjad, P.N.; Machewad, G.M.; Chappalwar, A.M.
Source:: Journal of food quality 2011 v.34 no.4 pp. 236-244
ISSN:: 0146-9428
Subject:: antimicrobial properties; cooking; eggs; emulsifiers; emulsions; food additives; functional properties; humans; lipid content; nutrition; patties; physicochemical properties; protein value; rabbit meat; sensory properties; spent hens; spoilage; temperature; thiobarbituric acid-reactive substances; vitamin B complex
Abstract:: ... A comminuted chicken patty was produced using spent hen and rabbit meats at 100:0, 95:5, 90:10, 85:15 and 80:20 ratios. The extenders/binders with whole liquid eggs (WLE) at 5, 10 and 15% and soy chunks at 3, 6 and 9%, respectively, were also used. The patties were evaluated for sensory, physicochemical and proximate quality and shelf life. The scores for all sensory attributes of patties stored a ...
DOI:: 10.1111/j.1745-4557.2011.00390.x
: https://doi.org/10.1111/j.1745-4557.2011.00390.x

53. Properties of different lactic acid bacteria isolated from Apis mellifera L. bee-gut

Author:: M. Carina Audisio; María J. Torres; Daniela C. Sabaté; Carolina Ibarguren; María C. Apella
Source:: Microbiological research 2011 v.166 no.1 pp. 1-13
ISSN:: 0944-5013
Subject:: American foul brood; Apis mellifera; Enterococcus faecium; Lactobacillus johnsonii; Paenibacillus larvae; digestive system; food pathogens; functional properties; humans; lactic acid; lactic acid bacteria; metabolites; polyacrylamide gel electrophoresis; polymerase chain reaction; ribosomal RNA; structural genes; worker bees
Abstract:: ... Eight strains belonging to Lactobacillus spp. and five to Enterococcus spp. were isolated from the gut of worker Apis mellifera L. bees. Studies based on 16S rRNA sequencing revealed that AJ5, IG9, A15 and CRL1647 strains had a 99% identity with Lactobacillus johnsonii, while SM21 showed a 99% similarity with Enterococcus faecium. L. johnsonii CRL1647, AJ5 and IG9 were high lactic acid producers ( ...
DOI:: 10.1016/j.micres.2010.01.003
: https://doi.org/10.1016/j.micres.2010.01.003

54. Ribosomal protein S18e as a putative molecular staple for the 18S rRNA 3′-major domain core

Author:: Aleksey A. Ilin; Alexey A. Malygin; Galina G. Karpova
Source:: Biochimica et biophysica acta 2011 v.1814 no.4 pp. 505-512
ISSN:: 1878-1454
Subject:: binding proteins; binding sites; circular dichroism spectroscopy; functional properties; humans; hydroxyl radicals; magnesium; messenger RNA; pH; prediction; protein secondary structure; ribosomal RNA; ribosomes; sequence alignment; urea
Abstract:: ... Ribosomal protein S18e is a structural constituent of the 40S ribosomal subunit. We obtained recombinant human ribosomal protein S18e and studied its structural and functional properties. With the use of CD spectroscopy we showed that the protein secondary structure is mainly helical and stable in the neutral pH range and at low urea concentrations. Applying multiple sequence alignment, we reveale ...
DOI:: 10.1016/j.bbapap.2011.01.005
: https://doi.org/10.1016/j.bbapap.2011.01.005

55. Shotgun proteomic analysis of microdissected postmortem human pituitary using complementary two-dimensional liquid chromatography coupled with tandem mass spectrometer

Author:: Yingchao Liu; Dongxiao Zhuang; Ruiping Hou; Jian Li; Guangming Xu; Tao Song; Luping Chen; Guoquan Yan; Qi Pang; Jianhong Zhu
Source:: Analytica chimica acta 2011 v.688 no.2 pp. 183-190
ISSN:: 0003-2670
Subject:: biomarkers; carcinogenesis; functional properties; humans; liquid chromatography; prolactin; protein synthesis; proteins; proteolysis; proteome; proteomics; reproduction; tandem mass spectrometry
Abstract:: ... The pituitary is responsible for multiple homeostatic functions including metabolism, growth and reproduction. Proteome analysis offers an efficient approach for a comprehensive analysis of pituitary protein expression. The pituitary is usually acquired from postmortem specimens, which may potentially affect the proteome profile by proteolysis. The aim of this study was to determine whether the po ...
DOI:: 10.1016/j.aca.2010.12.032
: https://doi.org/10.1016/j.aca.2010.12.032

56. 71. Cryopreservation of in vitroshoot-tips of a sweet potato Famaillá 6 clone (Ipomoea batatas (L.) Lam.) by droplet-vitrification technique

Author:: M.V. Rivero; A.M. Clausen; G. Monterubbianesi; A. Digilio
Source:: Cryobiology 2012 v.65 no.3 pp. 362
ISSN:: 0011-2240
Subject:: Ipomoea batatas; aluminum foil; anthocyanins; carotenoids; cryopreservation; disease prevention; ethylene glycol; exposure duration; functional properties; gene banks; genotype; germplasm; germplasm conservation; glycerol; humans; kinetin; labor force; micropropagation; minerals; nitrogen; risk; shoots; space and time; sucrose; sweet potatoes; temperature; vitamins; vitrification
Abstract:: ... Sweet potato varieties constitute a valuable germplasm as a source of carbohydrates, vitamins, fiber and minerals, with excellent functional properties in the prevention of diseases because of the presence of anthocyanins and carotenoids (Martí, 2008; CIP, 2009). The maintenance of germplasm in the field are under risk of losing material, high labor force, time and space consuming (Engelmann and E ...
DOI:: 10.1016/j.cryobiol.2012.07.071
: https://doi.org/10.1016/j.cryobiol.2012.07.071

57. A Pursuit of the Functional Nutritional and Bioactive Properties of Canola Proteins and Peptides

Author:: Ayyappan Appukuttan Aachary; Usha Thiyam
Source:: Critical reviews in food science and nutrition 2012 v.52 no.11 pp. 965-979
ISSN:: 1549-7852
Subject:: animal source protein; bioactive properties; canola; canola meal; digestibility; foods; gelation; humans; peptides; proteins; water holding capacity
Abstract:: ... This review focuses on updated information about canola proteins and peptides, their functional, nutritional, and bioactive properties, safety aspects, and potential application in foods. Attention is paid to gelation, emulsion, thermal, and water holding capacities of crude and pure proteins and peptides isolated from canola meal. Various factors affecting these properties are discussed. This pap ...
DOI:: 10.1080/10408398.2010.516033
PubMed:: 22823345
: https://doi.org/10.1080/10408398.2010.516033

58. A biological trait approach to assess the functional composition of subtidal benthic communities in an estuarine ecosystem

Author:: Pieter van der Linden; Joana Patrício; Agnese Marchini; Núria Cid; João Magalhães Neto; João Carlos Marques
Source:: Ecological indicators 2012 v.20 no. pp. 121-133
ISSN:: 1470-160X
Subject:: ecosystems; estuaries; functional diversity; functional properties; humans; invertebrates; salinity; species diversity; Portugal
Abstract:: ... Within transitional/estuarine environments ‘ecosystem functioning’ has been mostly investigated with “traditional” taxonomic analysis, based on the taxonomic composition of benthic invertebrate communities. However, ‘ecosystem functioning’ depends also greatly on the functional characteristics (biological traits) of organisms. It was a priori suggested that the biological traits of the subtidal be ...
DOI:: 10.1016/j.ecolind.2012.02.004
: https://doi.org/10.1016/j.ecolind.2012.02.004

59. An overview of separation methods in starch analysis: The importance of size exclusion chromatography and field flow fractionation

Author:: Heinrich RÃ¼bsam; Martin Krottenthaler; Martina Gastl; Thomas Becker
Source:: StaÌrke = 2012 v.64 no.9 pp. 683-695
ISSN:: 0038-9056
Subject:: fractionation; energy; humans; industry; starch; ultracentrifugation; gel chromatography; processed foods; biofuels; functional properties
Abstract:: ... Starch is the most important source of human food energy and also an important polymer for biofuels, processed food, and pharmaceutical industries. Precise determination of structural and functional properties of starch has been an outstanding factor for the improvement of dissolution and degradation processes, which are important procedures for commercial applications. Distinct separation techniq ...
DOI:: 10.1002/star.201100188
: https://doi.org/10.1002/star.201100188

60. Analysis of functional properties of biologically active substances using eukaryotic cell models (review)

Author:: K. V. Lisitskaya; I. V. Nikolaev; A. A. Torkova; V. O. Popov; O. V. Koroleva
Source:: Applied biochemistry and microbiology 2012 v.48 no.6 pp. 525-540
ISSN:: 0003-6838
Subject:: bioactive properties; cell culture; chemoprevention; eukaryotic cells; functional properties; humans; models; prebiotics
Abstract:: ... This work presents an analysis of current data on the investigation into the functional properties of biologically active substances in model systems based on cultivated human cells. The knowledge regarding the practical application of cell cultures for the analysis of functional properties of bioactive substances is summarized, including antioxidant, immunomodulating, pro- and prebiotics, and che ...
DOI:: 10.1134/S0003683812060087
: https://doi.org/10.1134/S0003683812060087

61. Cardiac tissue engineering using tissue printing technology and human cardiac progenitor cells

Author:: Roberto Gaetani; Peter A. Doevendans; Corina H.G. Metz; Jacqueline Alblas; Elisa Messina; Alessandro Giacomello; Joost P.G. Sluijter
Source:: Biomaterials 2012 v.33 no.6 pp. 1782-1790
ISSN:: 0142-9612
Subject:: biocompatible materials; bioprinting; cardiomyocytes; cell viability; functional properties; gene expression; humans; stem cells; therapeutics; tissue engineering; transcription factors
Abstract:: ... Tissue engineering is emerging as a potential therapeutic approach to overcome limitations of cell therapy, like cell retention and survival, as well as to mechanically support the ventricular wall and thereby prevent dilation. Tissue printing technology (TP) offers the possibility to deliver, in a defined and organized manner, scaffolding materials and living cells. The aim of our study was to ev ...
DOI:: 10.1016/j.biomaterials.2011.11.003
: https://doi.org/10.1016/j.biomaterials.2011.11.003

62. Characterization of the neuraminidase of the H1N1/09 pandemic influenza virus

Author:: T. Gerlach; L. Kühling; J. Uhlendorff; V. Laukemper; T. Matrosovich; V. Czudai-Matwich; F. Schwalm; H.-D. Klenk; M. Matrosovich
Source:: Vaccine 2012 v.30 no.51 pp. 7348-7352
ISSN:: 0264-410X
Subject:: Orthomyxoviridae; birds; erythrocytes; functional properties; genes; humans; hydrolysis; mucins; neutralization; pandemic; sialidase; swine; vaccines; vertebrate viruses; viruses
Abstract:: ... In this study, we compared properties of the neuraminidase (NA) of the H1N1/2009 pandemic virus (H1N1pdm) and N1 NAs of other influenza viruses. The H1N1pdm NA was more active than NAs of seasonal H1N1 viruses, hydrolyzed Neu5Acα2-3Gal linkage as efficiently as did avian viruses and cleaved Neu5Acα2-6Gal linkage as efficiently as classical swine viruses. To assess the functional balance between he ...
DOI:: 10.1016/j.vaccine.2012.09.078
: https://doi.org/10.1016/j.vaccine.2012.09.078

63. Comparability studies of new 3rd generation recombinant human factor VIII GreenGene F after improvement of formulation and viral inactivation/removal process

Author:: Sang Hoon Paik; Yong Jae Kim; Sang Kyul Han; Ji-youn Kim; Hanna Park; Young In Park
Source:: Biologicals 2012 v.40 no.6 pp. 405-414
ISSN:: 1045-1056
Subject:: World Health Organization; clinical trials; factor VIII; functional properties; humans; intravenous injection; manufacturing; mice; nanofiltration; pathogens; peptides; risk; solvents; toxicity; viruses; South Korea
Abstract:: ... A new 3rd generation recombinant factor VIII (rFVIII), GreenGene F (WHO INN: beroctocog alfa), which is a highly homogenous B-domain deleted FVIII protein comprising of two peptides as heavy chain (A1 and A2 domain) and light chain (A3, C1, and C2 domain) at 80 and 90 kDa, was developed from its predecessor product GreenGene (2nd generation product previously approved by Korea FDA after clinical s ...
DOI:: 10.1016/j.biologicals.2012.09.004
: https://doi.org/10.1016/j.biologicals.2012.09.004

64. Conserved functional characteristics of the PIWI family members in chicken germ cell lineage

Author:: T.H. Kim; T.W. Yun; D. Rengaraj; S.I. Lee; S.M. Lim; H.W. Seo; T.S. Park; J.Y. Han
Source:: Theriogenology 2012 v.78 no.9 pp. 1948-1959
ISSN:: 0093-691X
Subject:: RNA interference; genes; ribonucleases; males; gene expression; testes; embryogenesis; females; in situ hybridization; messenger RNA; complementary DNA; humans; mice; stem cells; cDNA libraries; chickens; quantitative polymerase chain reaction; proteins; germ cells; reverse transcriptase polymerase chain reaction; functional properties
Abstract:: ... The P-element-induced wimpy testis (PIWI) protein family, one of two subfamily members of Argonautes that regulate gene expression by associating with small noncoding RNAs, plays a role in maintaining the integrity of germ cells and stem cells. PIWI proteins have been identified and characterized in many species, including humans, mice, and zebrafish, but not as yet in avian species. In this study ...
DOI:: 10.1016/j.theriogenology.2012.07.019
PubMed:: 23058791
: https://doi.org/10.1016/j.theriogenology.2012.07.019

65. Establishment and characterization of immortalized human hepatocyte cell line for applications in bioartificial livers

Author:: XiaoPing Pan; JianZhou Li; WeiBo Du; XiaoPeng Yu; ChunXia Zhu; ChengBo Yu; HongCui Cao; YiMin Zhang; Yu Chen; LanJuan Li
Source:: Biotechnology letters 2012 v.34 no.12 pp. 2183-2190
ISSN:: 0141-5492
Subject:: messenger RNA; albumins; humans; neoplasms; glutamate-ammonia ligase; reverse transcriptase polymerase chain reaction; Western blotting; cytochrome P-450; gene expression; mice; genes; subcutaneous injection; transfection; functional properties; Macaca mulatta polyomavirus 1
Abstract:: ... An immortalized human hepatocyte cell line, HepLi5, was established via transfection of Simian virus 40 large T antigen (SV40 LT) into primary human hepatocytes. The morphologic and functional characteristics of HepLi5 cells were evaluated. The expression of SV40 LT in HepLi5 cells was detected by reverse transcription-PCR (RT-PCR) and western blotting. mRNA expression of liver-enriched genes, inc ...
DOI:: 10.1007/s10529-012-1025-1
PubMed:: 22930002
: https://doi.org/10.1007/s10529-012-1025-1

66. Flaxseed and Human Health: Reviewing Benefits and Adverse Effects

Author:: Júlia Cristina Cardoso Carraro; Maria Inês de Souza Dantas; Ana Cristina Rocha Espeschit; Hércia Stampini Duarte Martino; Sônia Machado Rocha Ribeiro
Source:: Food reviews international 2012 v.28 no.2 pp. 203-230
ISSN:: 1525-6103
Subject:: adverse effects; functional properties; human fertility; human health; humans; ingestion; lignans; linseed; men; nutrient availability; phytochemicals; pregnant women; risk; toxicity
Abstract:: ... Consumption of flaxseed has been increased due to its possible functional properties in health. However, its chronic consumption may offer risks considering the effects of lignans in men and in pregnant women, as well as the existence of other phytochemicals and toxic factors with adverse health effects in the seed. The present review focuses on the growing body of evidence on the potential health ...
DOI:: 10.1080/87559129.2011.595025
: https://doi.org/10.1080/87559129.2011.595025

67. Functional expression and characterization of an iron-containing superoxide dismutase of Acanthamoeba castellanii

Author:: Jung-Yeon Kim; Byoung-Kuk Na; Kyoung-Ju Song; Mi-Hyun Park; Yun-Kyu Park; Tong-Soo Kim
Source:: Parasitology research 2012 v.111 no.4 pp. 1673-1682
ISSN:: 0932-0113
Subject:: parasites; trophozoites; humans; oxidative stress; sequence alignment; hosts; hydrogen peroxide; superoxide dismutase; Acanthamoeba castellanii; pneumonia; cytosol; amino acid sequences; encephalitis; pH; functional properties; keratitis; exons; introns; Amoeba
Abstract:: ... Acanthamoeba spp. are free-living amoebae, but opportunistic infections of some strains of the organisms cause severe diseases such as acanthamoebic keratitis, pneumonitis, and granulomatous amoebic encephalitis in human. In this study, we identified a gene encoding iron superoxide dismutase of Acanthamoeba castellanii (AcFe-SOD) and characterized biochemical and functional properties of the recom ...
DOI:: 10.1007/s00436-012-3006-7
: https://doi.org/10.1007/s00436-012-3006-7

68. HSPBs: Small proteins with big implications in human disease

Author:: Harm H. Kampinga; Carmen Garrido
Source:: international journal of biochemistry & cell biology 2012 v.44 no.10 pp. 1706-1710
ISSN:: 1357-2725
Subject:: cell biology; functional properties; human diseases; humans; muscles; mutation; neuromuscular disorders; physiology; proteins; tissue degeneration; tissues
Abstract:: ... Although initially somewhat ignored, recent studies have now clearly established that the diverse members of the human family of small HSPs (HSPB1–HSPB10) play crucial roles in a wide range of cell types to maintain the integrity and function of tissues, in particular that of nervous and muscular tissue. The 10 human HSPBs clearly have overlapping and non-overlapping functional characteristics. Th ...
DOI:: 10.1016/j.biocel.2012.06.005
: https://doi.org/10.1016/j.biocel.2012.06.005

69. Hair cells, plasma membrane Ca²⁺ ATPase and deafness

Author:: Marta Giacomello; Agnese De Mario; Simona Primerano; Marisa Brini; Ernesto Carafoli
Source:: international journal of biochemistry & cell biology 2012 v.44 no.5 pp. 679-683
ISSN:: 1357-2725
Subject:: Ca2-transporting ATPase; actin; adenosinetriphosphatase; cadherins; calcium; deafness; ears; functional properties; hearing; humans; mice; mutation; phenotype; plasma membrane; potassium; sounds
Abstract:: ... Hearing relies on the ability of the inner ear to convert sound waves into electrical signals. The main actors in this process are hair cells. Their stereocilia contain a number of specific proteins and a scaffold of actin molecules. They are organized in bundles by tip-link filaments composed of cadherin 23 and protocadherin 15. The bundle is deflected by sound waves leading to the opening of mec ...
DOI:: 10.1016/j.biocel.2012.02.006
: https://doi.org/10.1016/j.biocel.2012.02.006

70. Human fibroblast-derived ECM as a scaffold for vascular tissue engineering

Author:: Jean-Michel Bourget; Robert Gauvin; Danielle Larouche; Amélie Lavoie; Raymond Labbé; François A. Auger; Lucie Germain
Source:: Biomaterials 2012 v.33 no.36 pp. 9205-9213
ISSN:: 0142-9612
Subject:: extracellular matrix; fibroblasts; functional properties; humans; myocytes; patients; saphenous vein; secretion; smooth muscle; tissue engineering
Abstract:: ... The self-assembly approach is based on the capability of mesenchymal cells to secrete and organize their own extracellular matrix (ECM). This tissue engineering method allows for the fabrication of autologous living tissues, such as tissue-engineered blood vessels (TEBV) and skin. However, the secretion of ECM by smooth muscle cells (SMCs), required to produce the vascular media, may represent a l ...
DOI:: 10.1016/j.biomaterials.2012.09.015
: https://doi.org/10.1016/j.biomaterials.2012.09.015

71. Identification and functional characterization of the novel human ether-a-go-go-related gene (hERG) R744P mutant associated with hereditary long QT syndrome 2

Author:: Parwez Aidery; Jana Kisselbach; Harald Gaspar; Ioana Baldea; Patrick A. Schweizer; Rüdiger Becker; Hugo A. Katus; Dierk Thomas
Source:: Biochemical and biophysical research communications 2012 v.418 no.4 pp. 830-835
ISSN:: 0006-291X
Subject:: Western blotting; Xenopus laevis; death; electrophysiology; functional properties; genes; humans; missense mutation; mutants; oocytes; pathogenicity; patients; potassium channels; protein subunits; syncope
Abstract:: ... Mutations of the cyclic nucleotide binding domain (CNBD) may disrupt human ether-a-go-go-related gene (hERG) K⁺ channel function and lead to hereditary long QT syndrome (LQTS). We identified a novel missense mutation located in close proximity to the CNBD, hERG R744P, in a patient presenting with recurrent syncope and aborted cardiac death triggered by sudden auditory stimuli. Functional propertie ...
DOI:: 10.1016/j.bbrc.2012.01.118
: https://doi.org/10.1016/j.bbrc.2012.01.118

72. In vitro investigations of the potential health benefits of Australian-grown faba beans (Vicia faba L.): chemopreventative capacity and inhibitory effects on the angiotensin-converting enzyme, α-glucosidase and lipase

Author:: Siem D. Siah; Izabela Konczak; Samson Agboola; Jennifer A. Wood; Christopher L. Blanchard
Source:: British journal of nutrition 2012 v.108 no.S1 pp. S123
ISSN:: 1475-2662
Subject:: DNA damage; Vicia faba; alpha-glucosidase; antioxidants; apoptosis; color; colored varieties; derivatization; diet; enzyme inhibition; faba beans; flow cytometry; functional properties; genotype; high performance liquid chromatography; human cell lines; humans; in vitro studies; leukemia; neoplasm cells; oxygen radical absorbance capacity; peptidyl-dipeptidase A; phenolic compounds; roasting; triacylglycerol lipase
Abstract:: ... The functional properties, including antioxidant and chemopreventative capacities as well as the inhibitory effects on angiotensin-converting enzyme (ACE), α-glucosidase and pancreatic lipase, of three Australian-grown faba bean genotypes (Nura, Rossa and TF(Ic*As)*483/13) were investigated using an array of in vitro assays. Chromatograms of on-line post column derivatisation assay coupled with HP ...
DOI:: 10.1017/S0007114512000803
PubMed:: 22916808
: https://doi.org/10.1017/S0007114512000803

73. Influence of perfusion and compression on the proliferation and differentiation of bone mesenchymal stromal cells seeded on polyurethane scaffolds

Author:: Chaoxu Liu; Reza Abedian; Roland Meister; Carl Haasper; Christof Hurschler; Christian Krettek; Gabriela von Lewinski; Michael Jagodzinski
Source:: Biomaterials 2012 v.33 no.4 pp. 1052-1064
ISSN:: 0142-9612
Subject:: bioreactors; functional properties; humans; irrigation; mechanical properties; polyurethanes; stromal cells; viability
Abstract:: ... In the present study, a porous meniscal-shaped scaffold consisting of polyurethane (PU)-based 1, 4-butanediisocyanate (BDI), which provided a 3-D culture condition for human bone mesenchymal stromal cells (hBMSC) was employed. A bioreactor was utilized to produce perfusion and mechanical stimulations. The viability, proliferation and fibro-cartilaginous differentiation of the hBMSC cultured on the ...
DOI:: 10.1016/j.biomaterials.2011.10.041
: https://doi.org/10.1016/j.biomaterials.2011.10.041

74. Mercury-ion optical sensors

Author:: Sherif A. El-Safty; M.A. Shenashen
Source:: Trends in analytical chemistry 2012 v.38 no. pp. 98-115
ISSN:: 0165-9936
Subject:: nervous system; receptors; waste management; functional properties; risk assessment; combustion; food chain; metal ions; fossil fuels; bioaccumulation; humans; monitoring; toxicity; markets; fluorescent dyes; adsorption; mercury; aquatic environment; volcanoes; mining
Abstract:: ... The toxicity of mercury (Hg) to humans, including damage to the nervous system, is well known. Hg cannot be degraded into non-toxic compounds or other elements. It is released mainly through mining, industries, and fossil fuel combustion. Anthropogenic and natural activities, such as volcanoes, transform elemental Hg (Hg⁰) into its ionic form [Hg(II)], which bioaccumulates in biota and is biomagni ...
DOI:: 10.1016/j.trac.2012.05.002
: https://doi.org/10.1016/j.trac.2012.05.002

75. Mitogenic response and probiotic characteristics of lactic acid bacteria isolated from indigenously pickled vegetables and fermented beverages

Author:: Mukesh Kumar; Moushumi Ghosh; Abhijit Ganguli
Source:: World journal of microbiology & biotechnology 2012 v.28 no.2 pp. 703-711
ISSN:: 0959-3993
Subject:: rice; pickled vegetables; Salmonella Typhimurium; gastric juice; hydrophobicity; Shigella flexneri; beverages; ribosomal DNA; phenol; splenocytes; Cronobacter sakazakii; Listeria monocytogenes; pathogens; humans; Aeromonas hydrophila; mice; bile; clinical trials; antibiotic resistance; antibiotics; salts; lactic acid bacteria; flowers; probiotics; pH; functional properties; Yersinia enterocolitica; Madhuca longifolia
Abstract:: ... Lactic acid bacteria from indigenous pickled vegetables and fermented beverages (fermented rice and Madhuca longifolia flowers) were isolated and investigated for their functional characteristics in vitro as potential new probiotic strains. Four isolates (all Lactobacillus spp.) selected on the basis of high tolerance to bile (0.2%) were identified by standard and molecular methods (16S rDNA) as L ...
DOI:: 10.1007/s11274-011-0866-4
PubMed:: 22806866
: https://doi.org/10.1007/s11274-011-0866-4

76. Natural killer cells: Frequency, phenotype and function in healthy cats

Author:: Ben L. Vermeulen; Bert Devriendt; Dominique A. Olyslaegers; Annelike Dedeurwaerder; Lowiese M. Desmarets; Korneel L. Grauwet; Herman W. Favoreel; Hannah L. Dewerchin; Hans J. Nauwynck
Source:: Veterinary immunology and immunopathology 2012 v.150 no.1-2 pp. 69-78
ISSN:: 0165-2427
Subject:: cats; cattle; cytotoxicity; functional properties; humans; immunity; kidney cells; lymph nodes; mice; natural killer cells; phenotype; sheep
Abstract:: ... Natural killer (NK) cells play a central role in innate immunity and have been shown to influence adaptive immune responses as well. This study aimed to provide a general NK cell quantification and phenotyping in several compartments of healthy cats and assess their functional properties. The results indicated that NK numbers, both absolute and relative, and phenotype mostly correspond with those ...
DOI:: 10.1016/j.vetimm.2012.08.010
PubMed:: 22985632
: https://doi.org/10.1016/j.vetimm.2012.08.010

77. Optimisation of microwave‐assisted extraction for functional properties of Vitis coignetiae extract by response surface methodology

Author:: Hyun‐Ku Kim; Jeong‐Ryong Do; Tae‐Soo Lim; Kashif Akram; Sung‐Ran Yoon; Joong‐Ho Kwon
Source:: Journal of the science of food and agriculture 2012 v.92 no.8 pp. 1780-1785
ISSN:: 0022-5142
Subject:: Vitis; consumer preferences; ethanol; functional properties; grapes; humans; monitoring; response surface methodology; superoxide dismutase
Abstract:: ... BACKGROUND: Consumer preference for selection of natural substances, with their safe and beneficial effects on the human body as well as various physiological efficacies, is increasing. In this study, response surface methodology (RSM) was used to monitor the extraction characteristics of Vitis coignetiae (wild grape) and thereby optimise the functional properties of the resulting extract. RESULTS ...
DOI:: 10.1002/jsfa.5546
PubMed:: 22227835
: https://doi.org/10.1002/jsfa.5546

78. PROTEOMICS in aquaculture: Applications and trends

Author:: Pedro M. Rodrigues; Tomé S. Silva; Jorge Dias; Flemming Jessen
Source:: Journal of proteomics 2012 v.75 no.14 pp. 4325-4345
ISSN:: 1874-3919
Subject:: functional foods; aquaculture; humans; fish production; food animals; seafoods; nutrition; farmed animal species; fish; proteomics; technology; functional properties
Abstract:: ... Over the last forty years global aquaculture presented a growth rate of 6.9% per annum with an amazing production of 52.5million tonnes in 2008, and a contribution of 43% of aquatic animal food for human consumption. In order to meet the world's health requirements of fish protein, a continuous growth in production is still expected for decades to come. Aquaculture is, though, a very competitive m ...
DOI:: 10.1016/j.jprot.2012.03.042
PubMed:: 22498885
: https://doi.org/10.1016/j.jprot.2012.03.042

79. Plasmodium vivax apicoplast genome: A comparative analysis of major genes from Indian field isolates

Author:: Vishal Saxena; Shilpi Garg; Jyotsna Tripathi; Sonal Sharma; Deepak Pakalapati; Amit K. Subudhi; P.A. Boopathi; Gagandeep S. Saggu; Sanjay K. Kochar; Dhanpat K. Kochar; Ashis Das
Source:: Acta tropica 2012 v.122 no.1 pp. 138-149
ISSN:: 0001-706X
Subject:: DNA-directed RNA polymerase; Plasmodium vivax; active sites; codons; correlation; disease severity; drugs; functional properties; humans; major genes; malaria; parasites; plastid DNA; proteinases; proteins; ribosomal RNA; Asia; South America
Abstract:: ... The apicomplexan parasite Plasmodium vivax is responsible for causing more than 70% of human malaria cases in Central and South America, Southeastern Asia and the Indian subcontinent. The rising severity of the disease and the increasing incidences of resistance shown by this parasite towards usual therapeutic regimens have necessitated investigation of putative novel drug targets to combat this d ...
DOI:: 10.1016/j.actatropica.2012.01.007
: https://doi.org/10.1016/j.actatropica.2012.01.007

80. Post-implant evaluation of the anastomotic mechanical and geometrical coupling between human native arteries and arterial cryografts implanted in lower-limb Mechanical, histological and ultraestructural studies of implanted cryografts

Author:: Daniel Bia; Yanina Zócalo; Ricardo L. Armentano; Héctor Pérez-Cámpos; Juan Fernández-Pin; Ana Panuncio; María Saldías; Ana Mariño; Inés Álvarez
Source:: Cryobiology 2012 v.64 no.1 pp. 50-59
ISSN:: 0011-2240
Subject:: polytetrafluoroethylene; humans; cryopreservation; prostheses; modulus of elasticity; mechanical properties; functional properties; arteries
Abstract:: ... BACKGROUND: There is an urgent need of vascular substitutes (VS) to be used in lower limb revascularization procedures when autologous veins are not available and synthetic prosthesis are contraindicated. Since the mechanical differences with respect to native vessels are determinants of the VS failure, the substitutes should have mechanical properties similar to those of the recipient vessels. Th ...
DOI:: 10.1016/j.cryobiol.2011.09.133
: https://doi.org/10.1016/j.cryobiol.2011.09.133

81. Protein aggregation: Mechanisms and functional consequences

Author:: Gaetano Invernizzi; Elena Papaleo; Raimon Sabate; Salvador Ventura
Source:: international journal of biochemistry & cell biology 2012 v.44 no.9 pp. 1541-1554
ISSN:: 1357-2725
Subject:: Alzheimer disease; amyloid; bacteria; bioinformatics; cell biology; functional properties; human diseases; humans; medicine; noninsulin-dependent diabetes mellitus
Abstract:: ... Understanding the mechanisms underlying protein misfolding and aggregation has become a central issue in biology and medicine. Compelling evidence show that the formation of amyloid aggregates has a negative impact in cell function and is behind the most prevalent human degenerative disorders, including Alzheimer's Parkinson's and Huntington's diseases or type 2 diabetes. Surprisingly, the same ty ...
DOI:: 10.1016/j.biocel.2012.05.023
: https://doi.org/10.1016/j.biocel.2012.05.023

82. Quaternary landscape history determines the soil functional characters of terroir

Author:: Edoardo A.C. Costantini; Pierluigi Bucelli; Simone Priori
Source:: Quaternary international 2012 v.265 no. pp. 63-73
ISSN:: 1040-6182
Subject:: acidity; astringency; financial economics; functional properties; geomorphology; humans; landscapes; paleosolic soil types; sediments; small fruits; soil formation; soil management; stakeholders; sugar content; sugars; vines; vineyards; viticulture; winemaking; wines
Abstract:: ... The soil functional properties that characterise the terroirs of a denomination of origin area are products and witnesses of the Quaternary events, natural and human induced, which occurred in that landscape. Knowing the Quaternary history can enhance the awareness of stakeholders about the possible environmental and economic losses that can derive from irrational soil management, which can lead t ...
DOI:: 10.1016/j.quaint.2011.08.021
: https://doi.org/10.1016/j.quaint.2011.08.021

83. Rat and human fatty acid amide hydrolases: Overt similarities and hidden differences

Author:: Almerinda Di Venere; Enrico Dainese; Filomena Fezza; Beatrice Clotilde Angelucci; Nicola Rosato; Benjamin F. Cravatt; Alessandro Finazzi-Agrò; Giampiero Mei; Mauro Maccarrone
Source:: Biochimica et biophysica acta 2012 v.1821 no.11 pp. 1425-1433
ISSN:: 1388-1981
Subject:: amide hydrolases; amides; animal models; esters; fatty acid metabolism; fatty acids; fluorescence emission spectroscopy; functional properties; human diseases; humans; light scattering; lipid bilayers; membrane proteins; neurotransmitters; new drugs; rats; sequence homology; structure-activity relationships
Abstract:: ... Fatty acid amide hydrolase (FAAH) is a membrane protein that plays a relevant role in the metabolism of fatty acid amides and esters. It degrades important neurotransmitters such as oleamide and anandamide, and it has been involved in a number of human pathological conditions, representing therefore a valuable target for biochemical and pharmacological research. In this study, we have investigated ...
DOI:: 10.1016/j.bbalip.2012.07.021
: https://doi.org/10.1016/j.bbalip.2012.07.021

84. Supplementation of Laying-Hen Feed with Palm Tocos and Algae Astaxanthin for Egg Yolk Nutrient Enrichment

Author:: Walker Laurie A.; Wang Tong; Xin Hongwei; Dolde David
Source:: Journal of agricultural and food chemistry 2012 v.60 no.8 pp. 1989-1999
ISSN:: 1520-5118
Subject:: tocopherols; diet; nutrient content; shelf life; humans; laying hens; emulsifying; sensory properties; astaxanthin; nutritive value; functional properties; tocotrienols; nutrients; eggs; antioxidants; egg yolk color
Abstract:: ... Adding supplements to hen feed can increase egg nutritional value. Astaxanthin, tocotrienols, and tocopherols are potent antioxidants that provide health benefits to humans. We hypothesized that the addition of these nutrients to hen feed would result in an increased nutrient content in egg yolk with minimum changes in functional properties. Laying hens (Hy-Line W-36 breed) were fed four diets wit ...
DOI:: 10.1021/jf204763f
PubMed:: 22276647
: https://doi.org/10.1021/jf204763f

85. A Tn antigen binding lectin from Myrsine coriacea displays toxicity in human cancer cell lines

Author:: Andrea Medeiros; Nora Berois; Marcelo Incerti; Sylvie Bay; Laura Franco Fraguas; Eduardo Osinaga
Source:: Natural medicines 2013 v.67 no.2 pp. 247-254
ISSN:: 1340-3443
Subject:: Myrsine; antigens; functional properties; glycosylation; humans; lectins; lymphocytes; molecular weight; toxicity
Abstract:: ... The Tn antigen (GalNAc-O-Ser/Thr) is one of the most specific human cancer-associated structures. In the present study we characterize the biochemical and functional properties of the Myrsine coriacea lectin (McL). We show that McL is an unusual high molecular weight highly glycosylated protein, which displays a strong Tn binding activity. The lectin exhibits in vitro inhibition of proliferation i ...
DOI:: 10.1007/s11418-012-0671-x
PubMed:: 22645079
: https://doi.org/10.1007/s11418-012-0671-x

86. Black Pepper and Health Claims: A Comprehensive Treatise

Author:: Masood Sadiq Butt; Imran Pasha; Muhammad Tauseef Sultan; Muhammad Atif Randhawa; Farhan Saeed; Waqas Ahmed
Source:: Critical reviews in food science and nutrition 2013 v.53 no.9 pp. 875-886
ISSN:: 1549-7852
Subject:: Piper nigrum; absorption; active ingredients; alkaloids; antidepressants; antioxidants; bioactive properties; black pepper; brain; cell culture; chemoprevention; cognition; cohort studies; functional foods; gastrointestinal system; health claims; healthy diet; humans; models; nutrients; oils; oleoresins; plant biochemistry; randomized clinical trials; trade
Abstract:: ... For millennia, spices have been an integral part of human diets and commerce. Recently, the widespread recognition of diet-health linkages bolsters their dietary importance. The bioactive components present in them are of considerable significance owing to their therapeutic potential against various ailments. They provide physiological benefits or prevent chronic ailment in addition to the fundame ...
DOI:: 10.1080/10408398.2011.571799
PubMed:: 23768180
: https://doi.org/10.1080/10408398.2011.571799

87. Functional characterization of fish neuroglobin: Zebrafish neuroglobin is highly expressed in amacrine cells after optic nerve injury and can translocate into ZF4 cells

Author:: Yuki Kamioka; Chieko Fujikawa; Kazuhiro Ogai; Kayo Sugitani; Seiji Watanabe; Satoru Kato; Keisuke Wakasugi
Source:: BBA - Proteins and Proteomics 2013 v.1834 pp. 1779-1788
ISSN:: 1570-9639
Subject:: Danio rerio; brain; cell death; cell membranes; chimerism; fish; functional properties; ganglia; heme; humans; hydrogen peroxide; immunohistochemistry; ischemia; messenger RNA; nerve tissue; neuroprotective effect; oxidative stress; oxygen; proteins; retina
Abstract:: ... Neuroglobin (Ngb) is a recently discovered vertebrate heme protein that is expressed in the brain and can reversibly bind oxygen. Mammalian Ngb is involved in neuroprotection under conditions of oxidative stress, such as ischemia and reperfusion. We previously found that zebrafish Ngb can penetrate the mammalian cell membrane. In the present study, we investigated the functional characteristics of ...
DOI:: 10.1016/j.bbapap.2013.02.021
: https://doi.org/10.1016/j.bbapap.2013.02.021

88. Functional properties and quality characteristics of bioactive compounds in berries: Biochemistry, biotechnology, and genomics

Author:: Sandra Neli Jimenez-Garcia; Ramon Gerardo Guevara-Gonzalez; Rita Miranda-Lopez; Ana Angelica Feregrino-Perez; Irineo Torres-Pacheco; Moises Alejandro Vazquez-Cruz
Source:: Food research international 2013 v.54 no.1 pp. 1195-1207
ISSN:: 0963-9969
Subject:: reactive oxygen species; value added; quantitative trait loci; bioavailability; human health; carotenoids; breeding methods; defense mechanisms; anthocyanins; metabolism; gene overexpression; humans; small fruits; tannins; diabetes; toxicity; plant breeding; fruits; loci; cardiovascular diseases; biotechnology; genomics; genetic techniques and protocols; functional properties; researchers
Abstract:: ... This review summarizes biological active compounds of berry fruits and their importance in relation to human health. The group of bioactive compounds consists of phenolic compounds, including anthocyanins, phenolic acids, stilbens, tannins, and carotenoids. Berries are important sources of a wide variety of bioactive compounds. Under stress conditions, reactive oxygen species (ROS) and free radica ...
DOI:: 10.1016/j.foodres.2012.11.004
: https://doi.org/10.1016/j.foodres.2012.11.004

89. Functionality and safety of lactic bacterial strains from Korean kimchi

Author:: Yosep Ji; Hannah Kim; Hyunjoon Park; Jieun Lee; Heejae Lee; Heuynkil Shin; Bongjoon Kim; Charles M.A.P. Franz; Wilhelm H. Holzapfel
Source:: Food control 2013 v.31 no.2 pp. 467-473
ISSN:: 0956-7135
Subject:: Lactobacillus fermentum; Lactobacillus plantarum; Lactobacillus rhamnosus; Leuconostoc citreum; ampicillin; antibiotic resistance; bile salts; biogenic amines; chloramphenicol; ciprofloxacin; duodenum; erythromycin; feces; food biotechnology; functional properties; gentamicin; hemolysis; humans; kimchi; pH; phenol; probiotics; streptomycin; swine; tetracycline
Abstract:: ... The functional characteristics and safety of five different putative probiotic Lactobacillus plantarum strains and one Leuconostoc citreum strain, isolated from kimchi, were studied. In view of their potential application in food biotechnology, this information was considered necessary, and included the determination of antibiotic resistance, haemolysis, gelatinase activity and biogenic amine prod ...
DOI:: 10.1016/j.foodcont.2012.10.034
: https://doi.org/10.1016/j.foodcont.2012.10.034

90. Interstitial cells of Cajal mediate excitatory sympathetic neurotransmission in guinea pig prostate

Author:: Jiang-ping Wang; Guo-fu Ding; Qin-zhang Wang
Source:: Cell and tissue research 2013 v.352 no.3 pp. 479-486
ISSN:: 0302-766X
Subject:: antagonists; dopamine; dopamine beta-monooxygenase; functional properties; guinea pigs; humans; immunohistochemistry; myocytes; nerve tissue; neurons; norepinephrine; smooth muscle; sympathetic nervous system; tyrosine
Abstract:: ... Morphological and functional studies have confirmed that interstitial cells of Cajal (ICCs) are involved in many enteric motor neurotransmission pathways. Recent investigations have demonstrated that human and guinea pig prostate glands possess a distinct cell type with morphological and immunological similarities to ICCs. These prostate ICCs have a close relationship with nerve bundles and smooth ...
DOI:: 10.1007/s00441-013-1572-3
PubMed:: 23411811
: https://doi.org/10.1007/s00441-013-1572-3

91. Methylglyoxal-induced modifications of hemoglobin: Structural and functional characteristics

Author:: Tania Bose; Abhishek Bhattacherjee; Sauradipta Banerjee; Abhay Sankar Chakraborti
Source:: Archives of biochemistry and biophysics 2013 v.529 no.2 pp. 99-104
ISSN:: 0003-9861
Subject:: absorbance; advanced glycation end products; diabetes mellitus; esterases; fluorescence; functional properties; heme; hemoglobin; humans; oxidative stress; peroxidase; spectroscopy; tryptophan
Abstract:: ... Methylglyoxal (MG) reacts with proteins to form advanced glycation end products (AGEs). Although hemoglobin modification by MG is known, the modified protein is not yet characterized. We have studied the nature of AGE formed by MG on human hemoglobin (HbA₀) and its effect on structure and function of the protein. After reaction of HbA₀ with MG, the modified protein (MG-Hb) was separated and its pr ...
DOI:: 10.1016/j.abb.2012.12.001
: https://doi.org/10.1016/j.abb.2012.12.001

92. New insights about medicinal uses and health-beneficial properties of cactus products

Author:: Nazareno, M.A.
Source:: Acta horticulturae 2013 no.995 pp. 237-250
ISSN:: 0567-7572
Subject:: Human immunodeficiency virus 1; Influenza A virus; Opuntia ficus-indica; animal ovaries; anti-inflammatory activity; anti-ulcer activity; antioxidants; antiviral properties; blood glucose; cacti and succulents; cactus pears; carcinogenesis; cholesterol; cladodes; diet; disease prevention; flowers; freeze drying; fruits; functional properties; glycemic effect; herbs; humans; hypercholesterolemia; models; noninsulin-dependent diabetes mellitus; obesity; ovarian neoplasms; oxidative stress; patients; pharmaceutical industry; phytochemicals; pigments; plant ovary; prostatic neoplasms; protective effect; rats; stomach ulcers; traditional medicine; triacylglycerols; vegetables; viruses
Abstract:: ... A review of the latest world-wide findings from scientific studies about the medicinal properties of cactus products is presented as well as their traditional and popular uses. Plants were used by ancient civilizations to cure diseases and heal wounds for thousands of years. Cactus cladodes, fruits, and flowers have been traditionally used as medicines in several countries. Cladodes are still used ...

93. Non-covalent and covalent modifications modulate the reactivity of monomeric mammalian globins

Author:: Paolo Ascenzi; Maria Marino; Fabio Polticelli; Massimo Coletta; Magda Gioia; Stefano Marini; Alessandra Pesce; Marco Nardini; Martino Bolognesi; Brandon J. Reeder; Michael T. Wilson
Source:: BBA - Proteins and Proteomics 2013 v.1834 pp. 1750-1756
ISSN:: 1570-9639
Subject:: Physeter macrocephalus; anaerobic conditions; cell viability; enzymes; functional properties; glycolysis; heme; hemoglobin; humans; hypoxia; mitochondria; myoglobin; neurons; nitric oxide; nitrites; oleic acid; oxidative phosphorylation; oxidative stress; oxygen
Abstract:: ... Multimeric globins (e.g., hemoglobin) are considered to be the prototypes of allosteric enzymes, whereas monomeric globins (e.g., myoglobin; Mb) usually are assumed to be non-allosteric. However, the modulation of the functional properties of monomeric globins by non-covalent (or allosteric) and covalent modifications casts doubts on this general assumption. Here, we report examples referable to t ...
DOI:: 10.1016/j.bbapap.2013.02.012
: https://doi.org/10.1016/j.bbapap.2013.02.012

94. Ontogenic development of cardiomyocytes derived from transgene-free human induced pluripotent stem cells and its homology with human heart

Author:: Glen Lester Sequiera; Ashish Mehta; Ting Huay Ooi; Winston Shim
Source:: Life sciences 2013 v.92 no.1 pp. 63-71
ISSN:: 0024-3205
Subject:: quantitative polymerase chain reaction; induced pluripotent stem cells; ion channels; medicine; humans; quinidine; structural genes; models; ontogeny; cardiomyocytes; somatic cells; gene expression; transcription (genetics); myosin light chains; sodium; verapamil; functional properties; fibroblasts; pharmacogenomics
Abstract:: ... AIM: Reprogramming of somatic cells utilizing viral free methods provide a remarkable method to generate human induced pluripotent stem cells (hiPSCs) for regenerative medicine. In this study, we evaluate developmental ontogeny of cardiomyocytes following induced differentiation of hiPSCs. MAIN METHODS: Fibroblasts were reprogrammed with episomal vectors to generate hiPSC and were subsequently dif ...
DOI:: 10.1016/j.lfs.2012.10.020
: https://doi.org/10.1016/j.lfs.2012.10.020

95. Physicochemical characterization and functional properties of galactomannans from mesquite seeds (Prosopis spp.)

Author:: Y.L. López-Franco; C.I. Cervantes-Montaño; K.G. Martínez-Robinson; J. Lizardi-Mendoza; L.E. Robles-Ozuna
Source:: Food hydrocolloids 2013 v.30 no.2 pp. 656-660
ISSN:: 0268-005X
Subject:: proteins; legumes; seeds; humans; galactose; galactomannans; Prosopis; heat; food industry; mannose; lipids; viscosity; water temperature; water content; melting point; functional properties; solubility; molecular weight; emulsions; calorimetry
Abstract:: ... In the present study, the physicochemical and functional characteristics of galactomannans (GM) from mesquite seeds were investigated and compared with the characteristics of a commercial GM. The mesquite gum was extracted with water at room temperature, and its physicochemical parameters, thermal constants and functional properties were determined. The results showed that mesquite GM had contents ...
DOI:: 10.1016/j.foodhyd.2012.08.012
: https://doi.org/10.1016/j.foodhyd.2012.08.012

96. Predispositions and Plasticity in Music and Speech Learning: Neural Correlates and Implications

Author:: Robert J. Zatorre
Source:: Science 2013 v.342 no.6158 pp. 585-589
ISSN:: 0036-8075
Subject:: brain; cognition; cortex; functional properties; humans; learning; music; speech
Abstract:: ... Speech and music are remarkable aspects of human cognition and sensory-motor processing. Cognitive neuroscience has focused on them to understand how brain function and structure are modified by learning. Recent evidence indicates that individual differences in anatomical and functional properties of the neural architecture also affect learning and performance in these domains. Here, neuroimaging ...
DOI:: 10.1126/science.1238414
: https://doi.org/10.1126/science.1238414

97. Structure and protective effect on UVB-induced keratinocyte damage of fructan from white garlic

Author:: Jinling Chen; Kit leong Cheong; Ziliang Song; Yujie Shi; Xuesong Huang
Source:: Carbohydrate polymers 2013 v.92 no.1 pp. 200-205
ISSN:: 0144-8617
Subject:: anion exchange chromatography; cellulose; chemical composition; chemical structure; fructose; functional properties; garlic; gel chromatography; glucose; humans; infrared spectroscopy; keratinocytes; molecular weight; nuclear magnetic resonance spectroscopy; polymerization; polymers; protective effect; ultraviolet radiation
Abstract:: ... The fructose polymer fructan was extracted from white garlic and fractionated using DEAE cellulose 52 and Sephadex G-100 columns to characterize its chemical composition and protective effect against ultraviolet radiation b (UVB) induced human keratinocyte (HaTaC) damage. Gel permeation chromatography, high performance anion exchange chromatography, infrared spectroscopy and 1D and 2D nuclear magn ...
DOI:: 10.1016/j.carbpol.2012.09.068
: https://doi.org/10.1016/j.carbpol.2012.09.068

98. Tenascin-C is expressed by human glioma in vivo and shows a strong association with tumor blood vessels

Author:: Nicole Brösicke; Frank K. H. van Landeghem; Björn Scheffler; Andreas Faissner
Source:: Cell and tissue research 2013 v.354 no.2 pp. 409-430
ISSN:: 0302-766X
Subject:: adhesion; blood vessels; cell division; cell proliferation; epitopes; extracellular matrix; fibronectins; functional properties; gene expression; humans; monoclonal antibodies; surgery
Abstract:: ... The extracellular matrix (ECM) protein tenascin-C (TN-C) is upregulated within glioma tissues and cultured glioma cell lines. TN-C possesses a multi-modular structure and a variety of functional properties have been reported for its domains. We describe five novel monoclonal antibodies identifying different domains of TN-C. The epitopes for these antibodies were investigated by using recombinantly ...
DOI:: 10.1007/s00441-013-1704-9
PubMed:: 23963648
: https://doi.org/10.1007/s00441-013-1704-9

99. The feline bile salt export pump: a structural and functional comparison with canine and human Bsep/BSEP

Author:: Cyrina D van Beusekom; Jeroen JMW van den Heuvel; Jan B Koenderink; Johannes A Schrickx; Frans GM Russel
Source:: BMC veterinary research 2013 v.9 no.1 pp. 259
ISSN:: 1746-6148
Subject:: bile; bile salts; cats; cell membranes; cholestasis; cholic acid; cyclosporine; cytotoxicity; dogs; drug development; excretion; functional properties; glycocholic acid; hepatocytes; humans; interspecific variation; ketoconazole; liver; liver diseases; models; open reading frames; taurocholic acid; transporters; veterinary drugs
Abstract:: ... BACKGROUND: The bile salt export pump (BSEP/ABCB11) is the primary transporter for the excretion of bile acids from hepatocytes into bile. In human, inhibition of BSEP by drugs has been related to drug-induced cholestasis and subsequent cytotoxic effects. The role of BSEP in canine and feline liver diseases has not been studied in detail, but the same mechanism of inhibition by drugs as in humans ...
DOI:: 10.1186/1746-6148-9-259
: https://doi.org/10.1186/1746-6148-9-259

100. The human topoisomerase 1B Arg634Ala mutation results in camptothecin resistance and loss of inter-domain motion correlation

Author:: Ilda D'Annessa; Cinzia Tesauro; Zhenxing Wang; Barbara Arnò; Laura Zuccaro; Paola Fiorani; Alessandro Desideri
Source:: BBA - Proteins and Proteomics 2013 v.1834 pp. 2712-2721
ISSN:: 1570-9639
Subject:: drug resistance; drugs; functional properties; humans; molecular dynamics; mutants; mutation; proteins; supercoiled DNA; tyrosine; viability; yeasts
Abstract:: ... Human topoisomerase 1B, the unique target of the natural anticancer compound camptothecin, catalyzes the unwinding of supercoiled DNA by introducing transient single strand nicks and providing covalent protein–DNA adducts. The functional properties and the drug reactivity of the single Arg634Ala mutant have been investigated in comparison to the wild type enzyme. The mutant is characterized by an ...
DOI:: 10.1016/j.bbapap.2013.09.017
: https://doi.org/10.1016/j.bbapap.2013.09.017

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1. Within‐ and Between‐Habitat Avian Diversity in African and Neotropical Lowland Habitats

2. Whey research

3. Identification and characterization of the mouse MutS homolog 5: Msh5

4. Human oxytocin receptors in cholesterol‐rich vs. cholesterol‐poor microdomains of the plasma membrane

5. Overproduction of spinach betaine aldehyde dehydrogenase in Escherichia coli: Structural and functional properties of wild‐type, mutants and E. coli enzymes

6. A Peptide Derived from Bovine β-Casein Modulates Functional Properties of Bone Marrow-Derived Macrophages from Germfree and Human Flora-Associated Mice

7. Recent Molecular Advances in Mammalian Glutamine Transport

8. The interaction of human apolipoprotein CâI with subâmicellar phospholipid

9. A functionally conserved member of the FTZâF1 nuclear receptor family from Schistosoma mansoni

10. Association of human tumor necrosis factor‐related apoptosis inducing ligand with membrane upon acidification

11. Ferritin from the spleen of the Antarctic teleost Trematomus bernacchii is an Mâtype homopolymer

12. Organization of six functional mouse alcohol dehydrogenase genes on two overlapping bacterial artificial chromosomes

13. Development and comparison of in vivo and in vitro models for endometritis in cows and mares

14. Kimchi and an Active Component, β-Sitosterol, Reduce Oncogenic H-Rasv12-Induced DNA Synthesis

15. Specificity and promiscuity of gonadotropin receptors

16. Barley yellow dwarf viruses (BYDVs) preserved in herbarium specimens illuminate historical disease ecology of invasive and native grasses

17. Differential structure and activity between human and mouse intelectin-1: Human intelectin-1 is a disulfide-linked trimer, whereas mouse homologue is a monomer

18. KBERG: KnowledgeBase for Estrogen Responsive Genes

19. Shallow lakes, the water framework directive and life. What should it all be about

20. Defining the functional properties of dietary protein and protein-rich foods in human energy expenditure

21. Generation of glyco-engineered Nicotiana benthamiana for the production of monoclonal antibodies with a homogeneous human-like N-glycan structure

22. Polymorphisms in the kappa casein (CSN3) gene in horse and comparative analysis of its promoter and coding region

23. Characteristics and Nutritional and Cardiovascular-Health Properties of Seaweeds

24. Design and humanization of a murine scFv that blocks human platelet glycoprotein VI in vitro

25. Evolutionary changes to transthyretin: structure-function relationships

26. Individual and combined action of pancreatic lipase and pancreatic lipase-related proteins 1 and 2 on native versus homogenized milk fat globules

27. Influence of conjugated linoleic acids on functional properties of vascular cells

28. Interleukin-1-inducible MCPIP protein has structural and functional properties of RNase and participates in degradation of IL-1β mRNA

29. Physicochemical Properties of β-Glucan in Differently Processed Oat Foods Influence Glycemic Response

30. Safety and Functional Aspects of Preselected Enterococci for Probiotic Use in Iberian Dry-Fermented Sausages

31. A simple method of surface functionalisation for immuno-specific immobilisation of proteins

32. CLERC and centrosomal leucine-rich repeat proteins

33. Effect of Lime and Wood Ash on the Nixtamalization of Maize and Tortilla Chemical and Nutritional Characteristics

34. Ovine bone marrow mesenchymal stem cells: isolation and characterization of the cells and their osteogenic differentiation potential on embroidered and surface-modified polycaprolactone-co-lactide scaffolds

35. Protein folding and aggregation in bacteria

36. Schwann-like cells can be induction from human nestin-positive amniotic fluid mesenchymal stem cells

37. Structural and Functional Alterations of Subcutaneous Small Resistance Arteries in Severe Human Obesity

38. The cytotoxic effect of Bowman-Birk isoinhibitors, IBB1 and IBBD2, from soybean (Glycine max) on HT29 human colorectal cancer cells is related to their intrinsic ability to inhibit serine proteases

39. CD11c⁺ Cells are Significantly Decreased in the Duodenum, Ileum and Colon of Dogs with Inflammatory Bowel Disease

40. Diversity of human skeletal muscle in health and disease: Contribution of proteomics

41. Effect of divalent cations on the porcine kidney cortex membrane-bound form of dipeptidyl peptidase IV

42. Electron microscopy morphology of the mitochondrial network in gliomas and their vascular microenvironment

43. Enzymatic hydrolysis of soy proteins and the hydrolysates utilisation

44. Expressed sequence identification and characterization of the cDNA for Interleukin-4 from the mitogen-stimulated lymphoid tissue of a marsupial, Macropus eugenii

45. Human hepatocytes and endothelial cells in organotypic membrane systems

46. In Vitro Fermentation by Human Gut Bacteria of Proteolytically Digested Caseinomacropeptide Nonenzymatically Glycosylated with Prebiotic Carbohydrates

47. In-vitro culture of Plasmodium falciparum: Utility of modified (RPNI) medium for drug-sensitivity studies using SYBR Green I assay

48. Matrigel improves functional properties of human submandibular salivary gland cell line

49. Mesenchymal stem cell like (MSCl) cells generated from human embryonic stem cells support pluripotent cell growth

50. Partial inactivation of CCR5- and CXCR4- tropic HIV-1 by human urine

51. Phytochemical profile, antioxidant, anti-inflammatory and hypoglycemic potential of hydroalcoholic extracts from Citrus medica L. cv Diamante flowers, leaves and fruits at two maturity stages

52. Process optimization for chicken patties manufactured with a combination of spent hen and rabbit meat

53. Properties of different lactic acid bacteria isolated from Apis mellifera L. bee-gut

54. Ribosomal protein S18e as a putative molecular staple for the 18S rRNA 3′-major domain core

55. Shotgun proteomic analysis of microdissected postmortem human pituitary using complementary two-dimensional liquid chromatography coupled with tandem mass spectrometer

56. 71. Cryopreservation of in vitroshoot-tips of a sweet potato Famaillá 6 clone (Ipomoea batatas (L.) Lam.) by droplet-vitrification technique

57. A Pursuit of the Functional Nutritional and Bioactive Properties of Canola Proteins and Peptides

58. A biological trait approach to assess the functional composition of subtidal benthic communities in an estuarine ecosystem

59. An overview of separation methods in starch analysis: The importance of size exclusion chromatography and field flow fractionation

60. Analysis of functional properties of biologically active substances using eukaryotic cell models (review)

61. Cardiac tissue engineering using tissue printing technology and human cardiac progenitor cells

62. Characterization of the neuraminidase of the H1N1/09 pandemic influenza virus

63. Comparability studies of new 3rd generation recombinant human factor VIII GreenGene F after improvement of formulation and viral inactivation/removal process

64. Conserved functional characteristics of the PIWI family members in chicken germ cell lineage

65. Establishment and characterization of immortalized human hepatocyte cell line for applications in bioartificial livers

66. Flaxseed and Human Health: Reviewing Benefits and Adverse Effects

67. Functional expression and characterization of an iron-containing superoxide dismutase of Acanthamoeba castellanii

68. HSPBs: Small proteins with big implications in human disease

69. Hair cells, plasma membrane Ca²⁺ ATPase and deafness

70. Human fibroblast-derived ECM as a scaffold for vascular tissue engineering

8. The interaction of human apolipoprotein CâI with subâmicellar phospholipid

9. A functionally conserved member of the FTZâF1 nuclear receptor family from Schistosoma mansoni

11. Ferritin from the spleen of the Antarctic teleost Trematomus bernacchii is an Mâtype homopolymer