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- Author:
- Shiv Shankar; Lily Jaiswal; Jong-Whan Rhim
- Source:
- Critical reviews in environmental science and technology 2021 v.51 no.20 pp. 2329-2356
- ISSN:
- 1547-6537
- Subject:
- antineoplastic activity; environmental science; humans; mechanism of action; sulfur
- Abstract:
- ... Recently, interest in sulfur nanoparticles (SNPs) and their applications in food, agriculture, and biomedical fields have increased mainly due to the significant antibacterial and anticancer activity of these nanomaterials. However, with these applications, there is a growing concern regarding the biological effects and the possible risks to the environment and health by the use of sulfur nanopart ...
- DOI:
- 10.1080/10643389.2020.1780880
- https://doi.org/10.1080/10643389.2020.1780880
- Author:
- Sebastian Torres; Hernán Verón; Luciana Contreras; Maria I. Isla
- Source:
- Food science and human wellness 2020 v.9 no.2 pp. 112-123
- ISSN:
- 2213-4530
- Subject:
- beverages; fermentation; fermented vegetables; fruits; functional properties; human health; humans; microorganisms; plant-based foods; shelf life; starter cultures; vegetables
- Abstract:
- ... Fermented plant-based foods and beverages constitute foods of high nutritional and functional value with appreciated health beneficial effects. They represent a natural and sustainable alternative to counteract the large wastage of vegetables and fruits due to their short shelf life. Usually, the use of controlled fermentation process using autochthonous microorganisms adapted to their vegetable m ...
- DOI:
- 10.1016/j.fshw.2020.02.006
- https://doi.org/10.1016/j.fshw.2020.02.006
- Author:
- Marina Fidelis; Mariana Araújo Vieira do Carmo; Thiago Mendanha da Cruz; Luciana Azevedo; Takao Myoda; Marianna Miranda Furtado; Mariza Boscacci Marques; Anderson S. Sant'Ana; Maria Inês Genovese; Won Young Oh; Mingchun Wen; Fereidoon Shahidi; Liang Zhang; Marcelo Franchin; Severino Matias de Alencar; Pedro Luiz Rosalen; Daniel Granato
- Source:
- Food chemistry 2020 v.310 pp. 125909
- ISSN:
- 0308-8146
- Subject:
- Myrciaria dubia; alpha-amylase; alpha-glucosidase; antihypertensive effect; antimicrobial properties; antioxidant activity; antioxidants; bioactive compounds; bioassays; cell culture; copper; cytotoxicity; enzyme inhibition; erythrocytes; functional properties; glycemic effect; hemolysis; humans; ingredients; low density lipoprotein; macrophages; neoplasm cells; neoplasms; oxidation; phenolic compounds; seeds; solvents; transcription factor NF-kappa B; tumor necrosis factor-alpha
- Abstract:
- ... Camu-camu (Myrciaria dubia) seeds are discarded without recovering the bioactive compounds. The main aim of the present work was to optimise the solvent mixture to extract higher total phenolic content and antioxidant capacity of camu-camu seeds. The optimised solvent system increased the extraction of phenolic compounds, in which vescalagin and castalagin were the main compounds. The optimised ex ...
- DOI:
- 10.1016/j.foodchem.2019.125909
- https://doi.org/10.1016/j.foodchem.2019.125909
- Author:
- Marion Bordier; Theethawat Uea-Anuwong; Aurélie Binot; Pascal Hendrikx; Flavie L. Goutard
- Source:
- Preventive veterinary medicine 2020 v.181 pp. 104560
- ISSN:
- 0167-5877
- Subject:
- One Health initiative; cost effectiveness; databases; environmental health; functional properties; governance; guidelines; health hazards; humans; monitoring; screening; stakeholders; uncertainty
- Abstract:
- ... The concept of One Health (OH) promotes the decompartmentalisation of human, animal, and ecosystem health for the more efficient and sustainable governance of complex health issues. This means that traditional boundaries between disciplines and sectors must be transgressed and that all relevant stakeholders must be involved in the definition and management of health problems. International efforts ...
- DOI:
- 10.1016/j.prevetmed.2018.10.005
- https://doi.org/10.1016/j.prevetmed.2018.10.005
- Author:
- Fernanda R.L. Rolim; Oliveiro C. Freitas Neto; Maria Elieidy G. Oliveira; Celso J.B. Oliveira; Rita C.R.E. Queiroga
- Source:
- Trends in food science & technology 2020 v.100 pp. 138-154
- ISSN:
- 0924-2244
- Subject:
- buffering capacity; cheeses; clinical trials; food matrix; foods; functional properties; humans; in vitro studies; in vivo studies; intestinal mucosa; mechanism of action; nutrient availability; oxygen; pH; probiotics; sensory properties; shelf life; viability
- Abstract:
- ... Probiotics are microorganisms that promote beneficial health effects. To do this, they must survive passage through the gastrointestinal tract, adhere and colonize in the intestinal epithelium. Foods are vehicles that protect these strains during this passage, in particular cheese, which has advantages such as availability of nutrients, high pH, higher buffering capacity and low oxygen content. Th ...
- DOI:
- 10.1016/j.tifs.2020.04.008
- https://doi.org/10.1016/j.tifs.2020.04.008
- Author:
- Amal Z. Barakat; Ahmed R. Hamed; Roqaya I. Bassuiny; Azza M. Abdel-Aty; Saleh A. Mohamed
- Source:
- Journal of food measurement & characterization 2020 v.14 no.2 pp. 1064-1072
- ISSN:
- 2193-4126
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Phoenix dactylifera; Serenoa repens; acetone; agroindustrial byproducts; anti-inflammatory activity; antibacterial properties; antifungal properties; antioxidant activity; antioxidants; bioactive compounds; enzyme inhibition; ethanol; flavonoids; functional properties; fungi; high performance liquid chromatography; humans; inducible nitric oxide synthase; inflammation; inhibitory concentration 50; minimum inhibitory concentration; multiple drug resistance; nitric oxide; protein synthesis; protocatechuic acid; seeds
- Abstract:
- ... The agricultural by-products are a significant source of health benefiting bioactive compounds. In this trend, the phenolic and flavonoid contents and functional properties of date palm seeds (DPS) and saw palmetto seeds (SPS) extracts were evaluated in this study. Considerable phenolic and flavonoid contents of 11.8, 7.75 mg GAE/g seed and 3.13, 1.1 mg CE/g seed were detected in DPS ethanol and S ...
- DOI:
- 10.1007/s11694-019-00356-5
- https://doi.org/10.1007/s11694-019-00356-5
- Author:
- Merve Çapkın Yurtsever; Arlin Kiremitci; Menemşe Gümüşderelioğlu
- Source:
- Journal of photochemistry and photobiology 2020 v.204 pp. 111742
- ISSN:
- 1011-1344
- Subject:
- brain; cell death; cell lines; culture media; diodes; dopamine; energy density; functional properties; humans; laminin; messenger RNA; near infrared radiation; neuroglia; neurons; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; stem cells; tooth pulp
- Abstract:
- ... Human dental pulp stem cells (hDPSCs) are able to differentiate into dopaminergic neurons and help the maintenance of partially degenerated neurons, which makes them as an alternative cell source for treatment of Parkinsons' disease (PD) patients. Here, the effect of photobiomodulation with polychromatic light source in the near infrared (NIR) range (600–1200 nm) or low level 660 nm diode laser li ...
- DOI:
- 10.1016/j.jphotobiol.2019.111742
- https://doi.org/10.1016/j.jphotobiol.2019.111742
- Author:
- Benjamin K. Mintah; Ronghai He; Akwasi A. Agyekum; Mokhtar Dabbour; Moses K. Golly; Haile Ma
- Source:
- Journal of food process engineering 2020 v.43 no.4 pp. e13362
- ISSN:
- 0145-8876
- Subject:
- Hermetia illucens; amino acids; edible insects; experimental design; fluorescence; functional properties; humans; industry; insect larvae; insect proteins; mathematical models; pests; protein composition; protein isolates; protein sources; response surface methodology
- Abstract:
- ... This study sought to establish an optimized procedure for extraction of protein from microwave‐dried larvae of an edible insect, Hermetia illucens (HIL), and to determine and compare the amino acid (AA) component, intrinsic fluorescence (IF), and physicochemical/functional properties (PFPs) of protein isolates. Box–Behnken's design with the Box–Wilson methodology was applied in the optimization pr ...
- DOI:
- 10.1111/jfpe.13362
- https://doi.org/10.1111/jfpe.13362
- Author:
- Yu Zhang; Hazel Bracken; Cheryl Woolhead; Michele Zagnoni
- Source:
- Biosensors & bioelectronics 2020 v.150 pp. 111920
- ISSN:
- 0956-5663
- Subject:
- biosensors; chlorides; droplets; electrophysiology; fluorescence; functional properties; geometry; hemolysins; humans; ion channels; lipid bilayers; oligomerization
- Abstract:
- ... Profiling ion flux through human intracellular chloride ion channels using live-cell based techniques, such as patch-clamp electrophysiology, is laborious and time-consuming. The integration of scalable microfluidic systems with automatable protocols based on droplet-interface-bilayers (DIBs) within which ion channels are incorporated circumvents several limitations associated with live-cell measu ...
- DOI:
- 10.1016/j.bios.2019.111920
- https://doi.org/10.1016/j.bios.2019.111920
- Author:
- Marina Jovanović; Snežana Zlatanović; Darko Micić; Dragan Bacić; Dragana Mitić-Ćulafić; Mihal Đuriš; Stanislava Gorjanović
- Source:
- Foods 2021 v.10 no.8 pp. -
- ISSN:
- 2304-8158
- Subject:
- Beta vulgaris; Escherichia coli; Streptococcus thermophilus; antibacterial properties; antineoplastic activity; antioxidants; beets; cell viability; cold storage; colorectal neoplasms; compressibility; consumer attitudes; cultured milk starters; dietary fiber; dogs; fermented beverages; flour; fluidized beds; food acceptability; food fortification; fortified foods; functional foods; functional properties; granules; humans; lactic acid bacteria; lactose; neoplasm cells; palatability; particle size; pomace; storage quality; storage time; yogurt
- Abstract:
- ... Following the idea of sustainability in food production, a yogurt premix based on beetroot (Beta vulgaris) pomace flour (BPF) was developed. BPF was granulated with lactose solution containing lactic acid bacteria (LAB) by a fluidized bed. Particle size increased ~30%. A decrease in Carr Index from 21.5 to 14.98 and Hausner ratio from 1.27 to 1.18 confirmed improved flowability of granulated BPF, ...
- DOI:
- 10.3390/foods10081696
- https://doi.org/10.3390/foods10081696
- Author:
- Takao Nagano; Yuya Arai; Hiromi Yano; Takafumi Aoki; Shin Kurihara; Rika Hirano; Katsuyoshi Nishinari
- Source:
- Food hydrocolloids 2020 v.109 pp. 105964
- ISSN:
- 0268-005X
- Subject:
- adverse effects; alpha-amylase; atomization; cellulose; cellulose nanofibers; contact dermatitis; dietary fiber; dietary supplements; enzyme activity; exercise; functional properties; healthy diet; high fat diet; humans; hydrocolloids; intestinal microorganisms; isoflavones; mice; nutritive value; obesity; okara; physicochemical properties; short chain fatty acids; soybeans; soymilk; surface area; texture; therapeutics; tofu; viscosity
- Abstract:
- ... Okara, the residue of the production of tofu and soybean milk, is rich in dietary fibers (DFs) and phytochemical components such as soy isoflavones (SIs) and soyasaponins (SSs). Despite its nutritive value, okara is scarcely used as a food source as the DFs in okara are mostly insoluble and have adverse effects on food texture. Thus, it is necessary to improve the physicochemical properties of oka ...
- DOI:
- 10.1016/j.foodhyd.2020.105964
- https://doi.org/10.1016/j.foodhyd.2020.105964
- Author:
- Nabil Smichi; Goetz Parsiegla; Neila Achouri; Zied Zarai; Abdelkarim Abousalham; Ahmed Fendri
- Source:
- International journal of biological macromolecules 2020 v.143 pp. 881-890
- ISSN:
- 0141-8130
- Subject:
- Diplodus sargus sargus; Escherichia coli; Sparus aurata; amino acids; catalytic activity; cell membranes; computer simulation; cytotoxicity; fish; functional properties; humans; inclusion bodies; intestines; lipid metabolism; macrophages; models; phosphatidylcholines; phospholipase A2; phospholipases; proteins; sequence analysis; thermal stability
- Abstract:
- ... Marine species have gained significant attention as potential source for a broad spectrum of bioactive proteins. Fish phospholipases A₂ (PLA₂) have attracted renewed interest due to their excellent properties in lipid digestion. Herein, we report for the first time the catalytic properties of two intestinal secreted PLA₂ (sPLA₂) identified from Diplodus sargus (IDsPLA₂) and Sparus aurata (ISaPLA₂) ...
- DOI:
- 10.1016/j.ijbiomac.2019.09.149
- https://doi.org/10.1016/j.ijbiomac.2019.09.149
- Author:
- Qiwei Ma; Zhaoya Gong; Jing Kang; Ran Tao; Anrong Dang
- Source:
- Remote Sensing 2020 v.12 no.16 pp. -
- ISSN:
- 2072-4292
- Subject:
- Landsat; case studies; cell communication; cities; dimensions; functional properties; geographic information systems; habitat fragmentation; humans; land surveying; land use; planning; population; remote sensing; shrinkage; surveys; urban areas; validity; China
- Abstract:
- ... Most of the shrinking cities experience an unbalanced deurbanization across different urban areas in cities. However, traditional ways of measuring urban shrinkage are focused on tracking population loss at the city level and are unable to capture the spatially heterogeneous shrinking patterns inside a city. Consequently, the spatial mechanism and patterns of urban shrinkage inside a city remain l ...
- DOI:
- 10.3390/rs12162513
- https://doi.org/10.3390/rs12162513
- Author:
- Lisa M. Smits; Stefano Magni; Kaoru Kinugawa; Kamil Grzyb; Joachim Luginbühl; Sonia Sabate-Soler; Silvia Bolognin; Jay W. Shin; Eiichiro Mori; Alexander Skupin; Jens C. Schwamborn
- Source:
- Cell and tissue research 2020 v.382 no.3 pp. 463-476
- ISSN:
- 0302-766X
- Subject:
- brain; dopamine; drugs; electrophysiology; functional properties; humans; image analysis; models; neurons; neurotransmitters; organoids; phenotype; research; sequence analysis; transcriptomics
- Abstract:
- ... Human stem cell-derived organoids have great potential for modelling physiological and pathological processes. They recapitulate in vitro the organization and function of a respective organ or part of an organ. Human midbrain organoids (hMOs) have been described to contain midbrain-specific dopaminergic neurons that release the neurotransmitter dopamine. However, the human midbrain contains also a ...
- DOI:
- 10.1007/s00441-020-03249-y
- https://doi.org/10.1007/s00441-020-03249-y
- Author:
- Ciarán McLaverty; Ole R. Eigaard; Henrik Gislason; Francois Bastardie; Mollie E. Brooks; Patrik Jonsson; Andreas Lehmann; Grete E. Dinesen
- Source:
- Ecological indicators 2020 v.110 pp. 105811
- ISSN:
- 1470-160X
- Subject:
- Nephrops norvegicus; benthic organisms; biomass; environmental factors; environmental indicators; fauna; fisheries management; fishery resources; functional diversity; functional properties; humans; population growth; salinity; sediments; temperature
- Abstract:
- ... Bottom trawling alters the abundance, diversity, size-composition, and function of benthic communities. However, the ability to detect these impacts over large spatial scales can be obscured by various complicating factors, such as community adaptation to disturbance and co-varying environmental conditions. An ecosystem-based approach to fisheries management therefore requires ecological indicator ...
- DOI:
- 10.1016/j.ecolind.2019.105811
- https://doi.org/10.1016/j.ecolind.2019.105811
- Author:
- Arleth S. López Rivero; Ma. Agustina Rossi; Eduardo A. Ceccarelli; Daniela L. Catalano-Dupuy
- Source:
- Biochimica et biophysica acta 2019 v.1863 no.4 pp. 651-660
- ISSN:
- 0304-4165
- Subject:
- Leptospira interrogans; bacteria; biochemical pathways; electrons; ferredoxin-NADP reductase; ferredoxins; functional properties; gene overexpression; genes; humans; mitochondria; models; mutagenesis; plastids
- Abstract:
- ... Ferredoxins are small iron-sulfur proteins that participate as electron donors in various metabolic pathways. They are recognized substrates of ferredoxin-NADP+ reductases (FNR) in redox metabolisms in mitochondria, plastids, and bacteria. We previously found a plastidic-type FNR in Leptospira interrogans (LepFNR), a parasitic bacterium of animals and humans. Nevertheless, we did not identify plan ...
- DOI:
- 10.1016/j.bbagen.2019.01.004
- https://doi.org/10.1016/j.bbagen.2019.01.004
- Author:
- Erwin Vera; Isabel Cornejo; Johanna Burgos; María Isabel Niemeyer; Francisco V. Sepúlveda; L. Pablo Cid
- Source:
- Biochemical and biophysical research communications 2019 v.514 no.3 pp. 574-579
- ISSN:
- 0006-291X
- Subject:
- choroid plexus; epithelium; functional properties; human cell lines; humans; kidneys; lungs; mice; mutation; permeability; plasma membrane; potassium channels; proteasome endopeptidase complex; retinal diseases; sodium-potassium-exchanging ATPase; vision
- Abstract:
- ... Kir7.1 is an inwardly rectifying K+ channel present in epithelia where it shares membrane localization with the Na+/K+-pump. In the present communication we report the presence of a novel splice variant of Kir7.1 in mouse tissues including kidney, lung, choroid plexus and retinal pigment epithelium (RPE). The variant named mKir7.1-SV2 lacks most of the C-terminus domain but is predicted to have th ...
- DOI:
- 10.1016/j.bbrc.2019.04.169
- https://doi.org/10.1016/j.bbrc.2019.04.169
- Author:
- Huifang Yuan; Xiaoyan Zheng; Wan Liu; Hui Zhang; Jingjing Shao; Jiaxin Yao; Chunyi Mao; Junfeng Hui; Daidi Fan
- Source:
- Colloids and surfaces 2020 v.192 pp. 111041
- ISSN:
- 0927-7765
- Subject:
- bioactive properties; biocompatibility; biocompatible materials; biomimetics; bone marrow; bovine serum albumin; cartilage; functional properties; humans; hydrogels; hydroxyapatite; in vivo studies; mesenchymal stromal cells; nanowires; porosity; sodium alginate; strength (mechanics); tissue engineering
- Abstract:
- ... Cartilage tissue engineering has become the trend of cartilage defect repair owing to the engineered biomimetic tissue that can mimic the structural, biological and functional characteristics of natural cartilage. Biomaterials with high biocompatibility and regeneration capacity are expected to be used in cartilage tissue engineering. Herein, in this study, a dual-network bovine serum albumin/sodi ...
- DOI:
- 10.1016/j.colsurfb.2020.111041
- https://doi.org/10.1016/j.colsurfb.2020.111041
- Author:
- R.M. Botelho; L.P.G. Tenorio; A.L.M. Silva; E.L.L. Tanabe; K.S.N. Pires; C.M. Gonçalves; J.C. Santos; A.L.X. Marques; M.J. Allard; J.D. Bergeron; G. Sebire; E.C.O. Silva; S.T. Souza; E.J.S. Fonseca; A.U. Borbely; K.S.C. Borbely
- Source:
- Biochimica et biophysica acta 2019 v.1863 no.9 pp. 1417-1428
- ISSN:
- 0304-4165
- Subject:
- Streptococcus agalactiae; atomic force microscopy; bacteria; biomechanics; cell death; cell viability; cytoskeleton; death; diet; fluorescent antibody technique; functional properties; humans; inflammation; interferon-gamma; interleukin-1beta; interleukin-2; interleukin-4; nitrites; olive oil; pregnancy; pregnant women; secretion; triterpenoids; trophoblast
- Abstract:
- ... Group B streptococcus (GBS) is the main bacteria that infects pregnant women and can cause abortion and chorioamnionitis. The impact of GBS effects on human trophoblast cells remains largely elusive, and actions toward anti-inflammatory strategies in pregnancy are needed. A potent anti-inflammatory molecule, uvaol is a triterpene from olive oil and its functions in trophoblasts are unknown. We aim ...
- DOI:
- 10.1016/j.bbagen.2019.06.012
- https://doi.org/10.1016/j.bbagen.2019.06.012
- Author:
- Atif B.A. Mohammed; Sakina Yagi; Tzvetomira Tzanova; Hervé Schohn; Haider Abdelgadir; Azzurra Stefanucci; Adriano Mollica; Mohamad Fawzi Mahomoodally; Talal A. Adlan; Gökhan Zengin
- Source:
- South African journal of botany 2020 v.132 pp. 403-409
- ISSN:
- 0254-6299
- Subject:
- Ocimum basilicum; Pulicaria undulata; acarbose; acetylcholinesterase; adenocarcinoma; alpha-amylase; antioxidant activity; antioxidants; assays; breast neoplasms; cell lines; cell viability; chemical composition; cholinesterase; colon; computer simulation; cosmetics; enzyme activity; enzyme inhibition; essential oils; free radicals; functional properties; gas chromatography-mass spectrometry; humans; ions; linalool; methyl chavicol; oils; pharmaceutical industry; stems; Sudan
- Abstract:
- ... In the present study, essential oils extracted from the leafy stems of Ocimum basilicum (Family Lamiaceae) and Pulicaria undulata (Family Asteraceae) were investigated for their chemical profiles and biological activity including antioxidant, antiproliferative and enzyme inhibition activities. The chemical composition of essential oil was determined using Gas Chromatography-Mass Spectrometry. The ...
- DOI:
- 10.1016/j.sajb.2020.06.006
- https://doi.org/10.1016/j.sajb.2020.06.006
- Author:
- Graziela Bragueto Escher; Mariza Boscacci Marques; Mariana Araújo Vieira do Carmo; Luciana Azevedo; Marianna Miranda Furtado; Anderson S. Sant'Ana; Marcia Cristina da Silva; Maria Inês Genovese; Mingchun Wen; Liang Zhang; Won Young Oh; Fereidoon Shahidi; Neiva Deliberali Rosso; Daniel Granato
- Source:
- Food research international 2020 v.128 pp. 108763
- ISSN:
- 0963-9969
- Subject:
- Clitoria ternatea; DNA; absorption; alpha-amylase; alpha-glucosidase; antihypertensive effect; antimicrobial properties; antioxidant activity; bioactive compounds; cell lines; cleavage (chemistry); corolla; cytotoxicity; enzyme activity; enzyme inhibition; erythrocytes; freeze drying; functional properties; hemolysis; humans; inhibitory concentration 50; lethal concentration 50; lipid peroxidation; low density lipoprotein cholesterol; oxidation; phenolic compounds; principal component analysis; protective effect; reactive oxygen species; temperature
- Abstract:
- ... The purpose of this study was to use a statistical approach to optimise the experimental conditions regarding the extraction of bioactive compounds, and to analyse the in vitro functional properties of crude lyophilized extracts (CLE) and partially purified (PPE) extracts of Clitoria ternatea petals. The results showed that the factors of temperature and time influenced the extraction of phenolic ...
- DOI:
- 10.1016/j.foodres.2019.108763
- https://doi.org/10.1016/j.foodres.2019.108763
- Author:
- Panagiotis G. Adamopoulos; Christos K. Kontos; Andreas Scorilas
- Source:
- Genomics 2019 v.111 no.4 pp. 642-652
- ISSN:
- 0888-7543
- Subject:
- alternative splicing; bioinformatics; biomarkers; functional properties; genes; high-throughput nucleotide sequencing; humans; neoplasm cells; neoplasms; plasma kallikrein; polymerase chain reaction; tissue kallikrein
- Abstract:
- ... Tissue kallikrein, kallikrein-related peptidases (KLKs), and plasma kallikrein form the largest group of serine proteases in the human genome, sharing many structural and functional properties. Several KLK transcripts have been found aberrantly expressed in numerous human malignancies, confirming their prognostic or/and diagnostic values. However, the process of alternative splicing can now be stu ...
- DOI:
- 10.1016/j.ygeno.2018.03.022
- https://doi.org/10.1016/j.ygeno.2018.03.022
- Author:
- Nidhi Joshi; Nupur Nagar; Khushboo Gulati; Krishnakant Gangele; Amit Mishra; Dinesh Kumar; Krishna Mohan Poluri
- Source:
- International journal of biological macromolecules 2020 v.156 pp. 239-251
- ISSN:
- 0141-8130
- Subject:
- Primates; Rodentia; cell movement; chemokine CCL2; comparative study; computer simulation; evolution; functional properties; glycosaminoglycans; glycosylation; humans; mice; monocytes; nuclear magnetic resonance spectroscopy; proteins
- Abstract:
- ... Chemokines are a sub-group of cytokines that regulate the leukocyte migration. Monocyte chemoattractant protein-1 (MCP/CCL2) is one of the essential CC chemokine that regulates the migration of monocytes into inflamed tissues. It has been observed that the primary sequences of CCL2 orthologs among rodents and primates vary significantly at the C-terminal region. However, no structural details are ...
- DOI:
- 10.1016/j.ijbiomac.2020.04.067
- https://doi.org/10.1016/j.ijbiomac.2020.04.067
- Author:
- Snježana Radulović; Benjamin Gottschalk; Gerd Hörl; Pablo Zardoya-Laguardia; Irene Schilcher; Seth Hallström; Nemanja Vujić; Kurt Schmidt; Markus Trieb; Wolfgang F. Graier; Roland Malli; Dagmar Kratky; Gunther Marsche; Saša Frank
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.4 pp. 158612
- ISSN:
- 1388-1981
- Subject:
- acyl coenzyme A; blood serum; carboxylic ester hydrolases; cholesterol; cholesterol acyltransferase; endothelial nitric oxide synthase; enzyme activity; filipin; functional properties; high density lipoprotein; human cell lines; humans; mice; microscopy; mitochondria; phosphorylation; plasma membrane; thin layer chromatography; vasodilation; viruses
- Abstract:
- ... Endothelial lipase (EL) changes structural and functional properties of high-density lipoprotein (HDL). HDL is a relevant modulator of endothelial nitric oxide synthase (eNOS) activity, but the effect of EL on HDL induced eNOS-activation has not yet been investigated. Here, we examined the impact of EL-modified HDL (EL-HDL) on eNOS activity, subcellular trafficking, and eNOS- dependent vasorelaxat ...
- DOI:
- 10.1016/j.bbalip.2020.158612
- https://doi.org/10.1016/j.bbalip.2020.158612
- Author:
- Wei Yuen Yap; Katrina Joan Shu Xian Tan; Jung Shan Hwang
- Source:
- Toxicon 2019 v.170 pp. 10-20
- ISSN:
- 0041-0101
- Subject:
- Hydra vulgaris; data collection; endoderm; females; functional properties; gene duplication; gene expression; genes; germ cells; hemolysis; humans; mutants; oogenesis; recombinant proteins; sequence analysis; sphingolipids; toxicity
- Abstract:
- ... Hydra actinoporin-like toxin 1 (HALT-1) was previously shown to cause cytolysis and haemolysis in a number of human cells and has similar functional properties to the actinoporins equinatoxin and sticholysin. In addition to HALT-1, five other HALTs (HALTs 2, 3, 4, 6 and 7) were also isolated from Hydra magnipapillata and expressed as recombinant proteins in this study. We demonstrated that recombi ...
- DOI:
- 10.1016/j.toxicon.2019.09.007
- https://doi.org/10.1016/j.toxicon.2019.09.007
- Author:
- Sneha B. Bansode; Rajesh N. Gacche
- Source:
- Biochimica et biophysica acta 2019 pp. -
- ISSN:
- 0304-4165
- Subject:
- advanced glycation end products; adverse effects; disease course; drugs; extracellular matrix; functional properties; glycation; humans; integrins; pathogenesis; receptors; signal transduction; tissues
- Abstract:
- ... Glycation driven generation of advanced glycation end products (AGEs) and their patho-physiological role in human degenerative diseases has remained one of the thrust areas in the mainstream of disease biology. Glycation of extracellular matrix (ECM) proteins have deleterious effect on the mechanical and functional properties of tissues. Owing to the adverse pathophysiological concerns of glycatio ...
- DOI:
- 10.1016/j.bbagen.2019.08.004
- https://doi.org/10.1016/j.bbagen.2019.08.004
- Author:
- Diana Rocha-Mendoza; Erica Kosmerl; Gonzalo Miyagusuku-Cruzado; M. Mónica Giusti; Rafael Jiménez-Flores; Israel García-Cano
- Source:
- Journal of dairy science 2020 v.103 no.9 pp. 7707-7718
- ISSN:
- 0022-0302
- Subject:
- Lactobacillus paracasei; Lactobacillus reuteri; Pediococcus acidilactici; absorbance; adhesion; bacterial adhesion; bile salts; digestive system; fermentation; food composition; functional properties; gene expression; genes; human cell lines; human health; humans; hydrophobicity; lactic acid bacteria; microbiome; milk; pH; phospholipids; probiotics; sugars; surface proteins
- Abstract:
- ... The mechanisms of bacterial adhesion to human cells involve several complex reactions and activation of genes and proteins. It has been reported that the food components in dairy matrices, such as sugar or salt, can decrease bacterial adhesion to Caco-2 cells. However, it has not been evaluated whether the bacteria grown in media supplemented with milk phospholipids (MPL) can increase or decrease ...
- DOI:
- 10.3168/jds.2020-18271
- https://doi.org/10.3168/jds.2020-18271
- Author:
- Cláudia Amorim; Sara C. Silvério; Beatriz B. Cardoso; Joana I. Alves; Maria Alcina Pereira; Lígia R. Rodrigues
- Source:
- Lebensmittel-Wissenschaft + Technologie 2020 v.126 pp. 109322
- ISSN:
- 0023-6438
- Subject:
- Bifidobacterium; Lactobacillus; Proteobacteria; ammonia; carbon dioxide; fermentation; functional properties; high-throughput nucleotide sequencing; human health; humans; ingredients; inoculum; intestinal microorganisms; lactic acid; lactulose; models; pH; prebiotics; raffinose; short chain fatty acids; volunteers
- Abstract:
- ... Until now the prebiotic potential of pure trisaccharide raffinose on human health assessed through high-throughput sequencing remains poorly investigated. In this work, an in vitro model using human fecal inocula of two healthy volunteers (D1 and D2) was used to study the prebiotic potential of raffinose and compare it with the well-stablished and commercial prebiotic lactulose. The intestinal mic ...
- DOI:
- 10.1016/j.lwt.2020.109322
- https://doi.org/10.1016/j.lwt.2020.109322
- Author:
- Keyu Tao; Wenwen Yu; Sangeeta Prakash; Robert G. Gilbert
- Source:
- Food science and human wellness 2020 v.9 no.2 pp. 130-135
- ISSN:
- 2213-4530
- Subject:
- amylose; consumer preferences; diabetes; foods; functional properties; gelatinization; hardness; humans; neoplasms; obesity; rice; screening; sensory evaluation; sensory properties; stickiness; swelling (materials); texture; viscosity
- Abstract:
- ... Foods wherein the starch is slowly digested contribute to good health by reducing the tendency to, and for the maintenance of, diabetes, obesity and colo-rectal cancers. While foods with high amylose content have this desirable property, they usually do not have high sensory appeal and consumers are reluctant to eat them. While sensory evaluation by trained human panelists is the best way to obtai ...
- DOI:
- 10.1016/j.fshw.2020.02.001
- https://doi.org/10.1016/j.fshw.2020.02.001
- Author:
- Rivca L. Valk-Weeber; Lubbert Dijkhuizen; Sander S. van Leeuwen
- Source:
- Carbohydrate research 2019 v.479 pp. 13-22
- ISSN:
- 0008-6215
- Subject:
- acetone; adsorption; detergents; functional properties; glycoproteins; humans; lactoferrin; peptide-N4-(N-acetyl-beta-glucosaminyl) asparagine amidase; polysaccharides; polystyrenes; ribonucleases; solid phase extraction; swine; thyroglobulin
- Abstract:
- ... Glycoproteins are biologically active proteins of which the attached glycans contribute to their biological functionality. Limited data is available on the functional properties of these N-glycans in isolation, without the protein core. Glycan release, typically performed with the PNGase F enzyme, is achieved on denatured proteins in the presence of detergents which are notoriously difficult to be ...
- DOI:
- 10.1016/j.carres.2019.04.011
- https://doi.org/10.1016/j.carres.2019.04.011
- Author:
- Delfine Cheng; Marco Morsch; Gerald J. Shami; Roger S. Chung; Filip Braet
- Source:
- Micron 2020 v.132 pp. 102851
- ISSN:
- 0968-4328
- Subject:
- Danio rerio; Kupffer cells; functional properties; genetics; hepatocytes; humans; image analysis; innate immunity; liver; models; pseudopodia; rodents; wastes
- Abstract:
- ... Kupffer cells are liver-resident macrophages that play an important role in mediating immune-related functions in mammals and humans. They are well-known for their capacity to phagocytose large amounts of waste complexes, cell debris, microbial particles and even malignant cells. Location, appearance and functional aspects are important features used to identify these characteristic cells of the l ...
- DOI:
- 10.1016/j.micron.2020.102851
- https://doi.org/10.1016/j.micron.2020.102851
- Author:
- Rui-Xia Chang; Ai-Ling Cui; Lu Dong; Su-Ping Guan; Ling-Yan Jiang; Cong-Xiu Miao
- Source:
- Open life sciences 2019 v.14 no.1 pp. 133-140
- ISSN:
- 2391-5412
- Subject:
- Western blotting; adenocarcinoma; bioactive properties; biomarkers; cell lines; cell proliferation; databases; functional properties; gene expression; humans; in vitro studies; mechanism of action; mitogen-activated protein kinase; neoplasm cells; ovarian neoplasms; patients; prognosis; proteins; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; signal transduction; statistical analysis; therapeutics; tissue repair; tissues
- Abstract:
- ... RAS protein activator like-1 (RASAL1) exists in numerous human tissues and has been commonly demonstrated to act as a tumor suppressor in several cancers. This study aimed to identify the functional characteristics of RASAL1 in ovarian adenocarcinoma and a potential mechanism of action. We analyzed RASAL1 gene expression in ovarian adenocarcinoma samples and normal samples gained from the GEO and ...
- DOI:
- 10.1515/biol-2019-0015
- https://doi.org/10.1515/biol-2019-0015
- Author:
- Tayler L. Hansen; Ellen M. Rankins; Jill M. Bobel; Meagan McKinney; Timothy J. Hackmann; Lori K. Warren
- Source:
- Journal of equine veterinary science 2020 v.88 pp. 102963
- ISSN:
- 0737-0806
- Subject:
- Dactylis glomerata; Quarter Horse; almond hulls; beets; blood glucose; blood serum; body weight; diet; feeds; functional properties; geldings; glucose; glycemic effect; hay; humans; ingredients; insulin; metabolism; oats; physiological response; soluble fiber; starch; sugar beet pulp
- Abstract:
- ... In humans, the consumption of soluble fibers reduces glycemic response after a meal. We hypothesized high soluble fiber diets would reduce and delay postprandial glucose and insulin responses in horses. In a 4 × 4 Latin square design experiment, four Quarter Horse geldings were adapted to diets containing orchardgrass hay (ORCH) or ORCH with 1 of 3 treatment ingredients: molassed sugar beet pulp ( ...
- DOI:
- 10.1016/j.jevs.2020.102963
- https://doi.org/10.1016/j.jevs.2020.102963
- Author:
- Simon J. Reider; Simon Moosmang; Judith Tragust; Lovro Trgovec-Greif; Simon Tragust; Lorenz Perschy; Nicole Przysiecki; Sonja Sturm; Herbert Tilg; Hermann Stuppner; Thomas Rattei; Alexander R. Moschen
- Source:
- Nutrients 2020 v.12 no.5 pp. -
- ISSN:
- 2072-6643
- Subject:
- Bacteroides; Roseburia; Ruminococcus; acetates; amino acids; blood serum; butyrates; clinical trials; feces; frequency; functional properties; germ-free animals; guar gum; humans; intestinal microorganisms; males; metabolites; metagenomics; models; nuclear magnetic resonance spectroscopy; nutrients; prebiotics; soluble fiber
- Abstract:
- ... (1) Background: Alterations in the structural composition of the human gut microbiota have been identified in various disease entities along with exciting mechanistic clues by reductionist gnotobiotic modeling. Improving health by beneficially modulating an altered microbiota is a promising treatment approach. Prebiotics, substrates selectively used by host microorganisms conferring a health benef ...
- DOI:
- 10.3390/nu12051257
- https://doi.org/10.3390/nu12051257
- Author:
- Satyamitra L. Shekh; Aarti A. Boricha; Jony G. Chavda; Bharatkumar Rajiv Manuel Vyas
- Source:
- Annals of microbiology 2020 v.70 no.1 pp. 16
- ISSN:
- 1590-4261
- Subject:
- Lactobacillus plantarum; biofilm; butyric acid; cells; cholesterol; choloylglycine hydrolase; digestive tract; enteropathogens; food spoilage; freeze drying; fructooligosaccharides; functional foods; functional properties; humans; intestines; inulin; lactulose; materials; methodology; mucins; prebiotics; probiotics; skim milk; storage; survival rate; viability
- Abstract:
- ... PURPOSE: Freeze drying of Lactobacillus plantarum GP in the presence of wall materials to achieve improved survival and retention of probiotic functionality during storage. METHODS: L. plantarum cells were lyophilized in the presence of inulin, fructooligosaccharides, lactulose, and/or skim milk. The lyophilized vials were stored at 8–10 °C up to 6 months and cells from these vials were evaluated ...
- DOI:
- 10.1186/s13213-020-01556-x
- https://doi.org/10.1186/s13213-020-01556-x
- Author:
- Bojie Fu
- Source:
- Geography and sustainability 2020 v.1 no.1 pp. 1-7
- ISSN:
- 2666-6839
- Subject:
- dynamics; ecosystem services; environment; functional properties; geography; humans; knowledge; methodology; models; objectives; research; social welfare; society; sustainability science and engineering; sustainable development
- Abstract:
- ... The discipline of geography encompasses both natural and social sciences and has the natural advantage of enabling the study of sustainability from a transdisciplinary perspective. There are great opportunities for geographers to participate in sustainability research. However, while geographers have set sustainability goals, they have rarely clarified the details for reaching those goals. Current ...
- DOI:
- 10.1016/j.geosus.2020.02.003
- https://doi.org/10.1016/j.geosus.2020.02.003
- Author:
- Christina Gkolfinopoulou; Angeliki Bourtsala; Angeliki Chroni
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.3 pp. 158593
- ISSN:
- 1388-1981
- Subject:
- apolipoprotein A-I; biogenesis; coronary artery disease; enzymes; functional properties; high density lipoprotein cholesterol; humans; phospholipids; point mutation; risk; thermodynamics
- Abstract:
- ... Several hereditary point mutations in human apolipoprotein A-I (apoA-I) have been associated with low HDL-cholesterol levels and/or increased coronary artery disease (CAD) risk. However, one apoA-I mutation, the V19L, recently identified in Icelanders, has been associated with increased HDL-cholesterol levels and decreased CAD risk. In an effort to gain mechanistic insight linking the presence of ...
- DOI:
- 10.1016/j.bbalip.2019.158593
- https://doi.org/10.1016/j.bbalip.2019.158593
- Author:
- Alexander M. Matyushenko; Daniil V. Shchepkin; Denis S. Susorov; Victoria V. Nefedova; Galina V. Kopylova; Valentina Y. Berg; Sergey Y. Kleymenov; Dmitrii I. Levitsky
- Source:
- Biochemical and biophysical research communications 2019 v.508 no.3 pp. 934-939
- ISSN:
- 0006-291X
- Subject:
- functional properties; humans; models; mutation; skeletal muscle; tropomyosins
- Abstract:
- ... Tropomyosin (Tpm) is an α-helical coiled-coil actin-binding protein that plays a key role in the Ca2+-regulated contraction of striated muscles. Two Tpm isoforms, α (Tpm 1.1) and β (Tpm 2.2), are expressed in fast skeletal muscles. These Tpm isoforms can form either αα and ββ homodimers, or αβ heterodimers. However, only αα-Tpm and αβ-Tpm dimers are usually present in most of fast skeletal muscles ...
- DOI:
- 10.1016/j.bbrc.2018.12.019
- https://doi.org/10.1016/j.bbrc.2018.12.019
- Author:
- Maryam Iftikhar; Asra Iftikhar; Huijuan Zhang; Lingxiao Gong; Jing Wang
- Source:
- Food research international 2020 v.136 pp. 109240
- ISSN:
- 0963-9969
- Subject:
- adverse effects; anti-inflammatory activity; antineoplastic activity; apoptosis; bioavailability; biotransformation; cell cycle checkpoints; cholesterol; drugs; functional foods; functional properties; humans; intestinal absorption; intestinal mucosa; mechanism of action; metabolism; molecular weight; neoplasm cells; oral administration; permeability; signal transduction; tight junctions
- Abstract:
- ... Caco-2, a human intestinal carcinoma cell line, has been used to test the absorption and transport mechanism of functional foods and drugs across the intestinal epithelium in order to study their antioxidant, anticancer and anti-inflammatory activities. Caco-2 cells represent the morphological and functional characteristics of small intestinal cells and capable of expressing brush borders, tight j ...
- DOI:
- 10.1016/j.foodres.2020.109240
- https://doi.org/10.1016/j.foodres.2020.109240
- Author:
- Bengt-Olof Nilsson
- Source:
- Peptides 2020 v.128 pp. 170311
- ISSN:
- 0196-9781
- Subject:
- Gram-negative bacteria; Porphyromonas gingivalis; Streptococcus mutans; antimicrobial peptides; antimicrobial properties; blood plasma; cell viability; epithelial cells; functional properties; granulocyte colony-stimulating factor; humans; innate immunity; models; neutropenia; neutrophils; pathogens; patients; periodontal diseases; saliva
- Abstract:
- ... The human antimicrobial peptide LL-37 is produced by neutrophils and epithelial cells, and the peptide can be detected in plasma as well as saliva. LL-37 is active against both gram-positive and gram-negative bacteria including oral pathogens such as Porphyromonas gingivalis and Streptococcus mutans. Besides its antimicrobial properties, LL-37 modulates the innate immune system, and furthermore, i ...
- DOI:
- 10.1016/j.peptides.2020.170311
- https://doi.org/10.1016/j.peptides.2020.170311
- Author:
- Caroline J. Gallant; Ulf Landegren
- Source:
- FEBS journal 2019 v.286 no.8 pp. 1442-1444
- ISSN:
- 1742-464X
- Subject:
- functional properties; humans; medicine; research programs; therapeutics
- Abstract:
- ... Single‐cell analysis is impacting biology and medicine by changing the scale and resolution at which we investigate multicellular organisms. A particular, overarching aim of this field is to characterize the programmed development of all different cell types in the human body, as well as their individual spatial, molecular, and functional characteristics. This vast research program is generating a ...
- DOI:
- 10.1111/febs.14820
- https://doi.org/10.1111/febs.14820
- Author:
- Flávia Roberta Buss Marenda; Fernanda Mattioda; Ivo Mottin Demiate; Alicia de Francisco; Carmen Lúcia de Oliveira Petkowicz; Maria Helene Giovanetti Canteri; Renata Dias de Mello Castanho Amboni
- Source:
- Journal of polymers and the environment 2019 v.27 no.3 pp. 549-560
- ISSN:
- 1566-2543
- Subject:
- acetylation; analgesic effect; chemical structure; drug formulations; economic investment; esterification; foods; functional properties; galacturonic acid; humans; in vivo studies; industry; mechanism of action; molecular weight; pectins; raw materials; vegetable residues
- Abstract:
- ... Vegetable waste represents a serious environmental problem for industries; however, it is also a valuable source of pectic substances. This paper aims to highlight the advances that have been made through studies regarding pectic substances from vegetable wastes, as well as providing an overview of the chemical structure of pectin, extraction and characterisation techniques, and potential applicat ...
- DOI:
- 10.1007/s10924-018-1355-8
- https://doi.org/10.1007/s10924-018-1355-8
- Author:
- Katerina C. Nastou; Michail A. Batskinis; Zoi I. Litou; Stavros J. Hamodrakas; Vassiliki A. Iconomidou
- Source:
- Journal of proteome research 2019 v.18 no.5 pp. 2310-2320
- ISSN:
- 1535-3907
- Subject:
- amino acid sequences; arginine; cysteine; databases; electric potential difference; functional properties; genetic variation; glutamine; histidine; humans; ion channels; membrane potential; phenotype; proteome; single nucleotide polymorphism; statistical analysis; topology; transmembrane proteins
- Abstract:
- ... Voltage-gated ion channels (VGICs) are one of the largest groups of transmembrane proteins. Due to their major role in the generation and propagation of electrical signals, VGICs are considered important from a medical viewpoint, and their dysfunction is often associated with Channelopathies. We identified disease-associated mutations and polymorphisms in these proteins through mapping missense si ...
- DOI:
- 10.1021/acs.jproteome.9b00121
- https://doi.org/10.1021/acs.jproteome.9b00121
- Author:
- E.D.N.S. Abeyrathne; X. Huang; D.U. Ahn
- Source:
- Poultry science 2018 v.97 no.4 pp. 1462-1468
- ISSN:
- 0032-5791
- Subject:
- antimicrobial properties; antioxidants; avidin; chemical treatment; egg albumen; enzymatic hydrolysis; enzyme inhibition; food processing; functional properties; heat treatment; humans; lysozyme; molecular weight; ovalbumin; ovomucin; pH; peptides; peptidyl-dipeptidase A
- Abstract:
- ... Egg white contains many functionally important proteins: ovalbumin (54%), ovotransferrin (12%), ovomucoid (11%), ovoglobulin (G2 and G3, 8%), ovomucin (3.5%), and lysozyme (3.5%) are major proteins, while ovoinhibitors, ovomacroglobulin, ovoglycoprotein, ovoflavoprotein, thiamine-binding proteins, and avidin are minor proteins present in egg white. These proteins, as well as the peptides derived f ...
- DOI:
- 10.3382/ps/pex399
- https://doi.org/10.3382/ps/pex399
- Author:
- M. Mayer-Pinto; K.A. Dafforn; A.B. Bugnot; T.M. Glasby; E.L. Johnston
- Source:
- Marine environmental research 2018 v.139 pp. 136-143
- ISSN:
- 0141-1136
- Subject:
- Ecklonia radiata; anthropogenic activities; biomechanics; detritus; ecological footprint; environmental impact; estuaries; functional properties; habitats; humans; infrastructure; macroalgae; marine environment; photosynthesis; prediction; reefs; secondary productivity; sublethal effects; urbanization
- Abstract:
- ... Assessments of human impacts on natural habitats often focus on the abundance of component species, yet physiological and/or sub-lethal effects of stressors on functional attributes may be equally important to consider. Here we evaluated how artificial structures, an integral part of urbanisation in the marine environment, affects key functional properties of the habitat-forming kelp Ecklonia radi ...
- DOI:
- 10.1016/j.marenvres.2018.05.004
- https://doi.org/10.1016/j.marenvres.2018.05.004
- Author:
- Zhen-Hui Cao; Julia M. Green-Johnson; Nicole D. Buckley; Qiu-Ye Lin
- Source:
- Biotechnology advances 2019 v.37 no.1 pp. 223-238
- ISSN:
- 0734-9750
- Subject:
- animal models; bioactive compounds; consumer demand; diet; fermentation; flavor; functional properties; guidelines; humans; lifestyle; medical history; metabolites; microbial communities; microbiome; microorganisms; natto; nutritive value; soy sauce; soymilk; tempeh; toxicity; Asia
- Abstract:
- ... For centuries, fermented soy foods have been dietary staples in Asia and, now, in response to consumer demand, they are available throughout the world. Fermentation bestows unique flavors, boosts nutritional values and increases or adds new functional properties. In this review, we describe the functional properties and underlying action mechanisms of soy-based fermented foods such as Natto, ferme ...
- DOI:
- 10.1016/j.biotechadv.2018.12.001
- https://doi.org/10.1016/j.biotechadv.2018.12.001
- Author:
- Roberto Portillo-Lara; Andrew R. Spencer; Brian W. Walker; Ehsan Shirzaei Sani; Nasim Annabi
- Source:
- Biomaterials 2019 v.198 pp. 78-94
- ISSN:
- 0142-9612
- Subject:
- biocompatible materials; biofabrication; biomimetics; cardiovascular diseases; cell engineering; diagnostic techniques; drugs; functional properties; genetic engineering; health services; humans; industry; microfluidic technology; mortality; myocardium; organ-on-a-chip; patients; screening; stem cells; therapeutics; tissue engineering
- Abstract:
- ... Bioengineered tissues have become increasingly more sophisticated owing to recent advancements in the fields of biomaterials, microfabrication, microfluidics, genetic engineering, and stem cell and developmental biology. In the coming years, the ability to engineer artificial constructs that accurately mimic the compositional, architectural, and functional properties of human tissues, will profoun ...
- DOI:
- 10.1016/j.biomaterials.2018.08.010
- https://doi.org/10.1016/j.biomaterials.2018.08.010
- Author:
- Aritra Bej; Juhi A. Rasquinha; Sujoy Mukherjee
- Source:
- Biochemistry 2018 v.57 no.44 pp. 6265-6269
- ISSN:
- 1520-4995
- Subject:
- Gibbs free energy; denaturation; entropy; functional properties; humans; molecular dynamics; mutants; mutation; neoplasms; nuclear magnetic resonance spectroscopy; regression analysis; simulation models; therapeutics; tumor suppressor protein p53; urea
- Abstract:
- ... Mutations in the core domain of tumor suppressor protein p53 have been associated with ∼50% of the occurrences of human cancers. A majority of these mutations inactivate p53 function by destabilizing its native structure. Although studies have shown p53’s function can be restored by stabilizing the mutants to their wild-type conformation with immense therapeutic potential, its applicability has be ...
- DOI:
- 10.1021/acs.biochem.8b00740
- https://doi.org/10.1021/acs.biochem.8b00740
- Author:
- Giada Rossignoli; Alessandro Grottesi; Giovanni Bisello; Riccardo Montioli; Carla Borri Voltattorni; Alessandro Paiardini; Mariarita Bertoldi
- Source:
- Biochemistry 2018 v.57 no.44 pp. 6336-6348
- ISSN:
- 1520-4995
- Subject:
- active sites; amino acid sequences; bioactive compounds; bioinformatics; cell growth; cysteine; functional properties; gastrointestinal system; histamine; histidine; histidine decarboxylase; humans; molecular dynamics; oxidation; protein content; pyridoxal; pyridoxal phosphate; reducing agents; simulation models
- Abstract:
- ... Histidine decarboxylase is a pyridoxal 5′-phosphate enzyme catalyzing the conversion of histidine to histamine, a bioactive molecule exerting its role in many modulatory processes. The human enzyme is involved in many physiological functions, such as neurotransmission, gastrointestinal track function, cell growth, and differentiation. Here, we studied the functional properties of the human enzyme ...
- DOI:
- 10.1021/acs.biochem.8b00625
- https://doi.org/10.1021/acs.biochem.8b00625
- Author:
- Neethu Puthumadathil; Poornendhu Jayasree; K. Santhosh Kumar; K. Madhavan Nampoothiri; Harsha Bajaj; Kozhinjampara R. Mahendran
- Source:
- Biomaterials science 2019 v.7 no.8 pp. 3226-3237
- ISSN:
- 2047-4849
- Subject:
- antimicrobial peptides; detergents; functional properties; humans; lipid bilayers; mechanism of action; micelles; molecular models; permeability; sodium dodecyl sulfate; therapeutics
- Abstract:
- ... The pore-forming structures of an anionic human antimicrobial peptide dermcidin (DCD) in a membrane environment has not been demonstrated previously. Using single-channel electrical recordings, we characterized the structural and functional properties of the DCD peptide channel in lipid membranes. We show that a 48-residue, 8 nm long anionic DCD-1L peptide is folded in the right conformation in so ...
- DOI:
- 10.1039/c9bm00181f
- https://doi.org/10.1039/c9bm00181f
- Author:
- J. H. Kim; K. J. Gellatly; B. Lueke; M. Kohler; R. Nauen; E. Murenzi; K. S. Yoon; J. M. Clark
- Source:
- Insect molecular biology 2018 v.27 no.1 pp. 73-82
- ISSN:
- 0962-1075
- Subject:
- ABC transporters; Baculoviridae; DDT (pesticide); Pediculus humanus; adenine; cytochrome P-450; evolution; functional properties; genes; humans; insecticides; insects; ivermectin; lice; liquids; metabolism; oocytes; spectral analysis; tritium; xenobiotics
- Abstract:
- ... We previously observed that ivermectin‐induced detoxification genes, including ATP binding cassette transporter C4 (PhABCC4) and cytochrome P450 6CJ1 (CYP6CJ1) were identified from body lice following a brief exposure to a sublethal dose of ivermectin using a non‐invasive induction assay. In this current study, the functional properties of PhABCC4 and CYP6CJ1 were investigated after expression in ...
- DOI:
- 10.1111/imb.12348
- https://doi.org/10.1111/imb.12348
- Author:
- Chao Zhao; Yuanyuan Liu; Shanshan Lai; Hui Cao; Yi Guan; Wai San Cheang; Bin Liu; Kewei Zhao; Song Miao; Céline Riviere; Esra Capanoglu; Jianbo Xiao
- Source:
- Trends in food science & technology 2019 v.85 pp. 55-66
- ISSN:
- 0924-2244
- Subject:
- antineoplastic activity; antioxidant activity; ascorbic acid; bioavailability; carotenoids; chlorophyll; cooking; crude fat; dietary fiber; dietary supplements; digestibility; flavonols; foods; functional properties; glucosinolates; humans; minerals; nutrients; nutritive value; palatability; polyphenols
- Abstract:
- ... Foods are good sources of vitamins, minerals and dietary fibers as well as phytochemicals, which are beneficial for the human body as nutritional supplements. The nutritional value (crude fibers, crude proteins, crude fats, flavonols, carotenoids, polyphenols, glucosinolate, chlorophyll, and ascorbic acid) and biological or functional properties (antioxidant activity, anticancer activity, or anti- ...
- DOI:
- 10.1016/j.tifs.2019.01.004
- https://doi.org/10.1016/j.tifs.2019.01.004
- Author:
- Diego Fernandes Gomes Pereira; José Max Barbosa de Oliveira Junior; Leandro Juen
- Source:
- Ecological indicators 2019 v.98 pp. 179-192
- ISSN:
- 1470-160X
- Subject:
- Libellulidae; Zygoptera; abdomen; adults; biodiversity; ecophysiology; endophytes; environmental factors; environmental indicators; extinction; functional properties; habitats; humans; livestock; macrophytes; oviposition; plantations; streams; thermoregulation; thorax; Amazonia
- Abstract:
- ... Species occurrence can be affected by the availability of environments that fit within the limits of variation of its niche and by interaction with other species. Modifications in the environment, especially those caused by mankind, are considered the leading cause for species extinction. Such a response from the species is not random, with patterns that can follow functionality and/or morphology ...
- DOI:
- 10.1016/j.ecolind.2018.09.020
- https://doi.org/10.1016/j.ecolind.2018.09.020
- Author:
- Shirin Ferdowsi; Ali Akbar Pourfathollah; Fatemeh Amiri; Mohammad Hessam Rafiee; Afsaneh Aghaei
- Source:
- Life sciences 2019 v.224 pp. 249-254
- ISSN:
- 0024-3205
- Subject:
- T-lymphocytes; Western blotting; antineoplastic activity; apoptosis; blood banks; caspase-3; cell viability; cytoplasmic granules; disulfide bonds; drug therapy; drugs; filters; fluorescence; functional properties; humans; neutrophils; peptides
- Abstract:
- ... The α-defensins or human neutrophil peptides (HNP 1–3) that exist in azurophilic granules are found to have anticancer activity. The pattern of disulfide bonds in α-defensins is crucial for the functional properties. Therefore, synthesis using the chemical and recombinant approaches is a challenging. A safe source for the production of α-defensins can be the use of leukoreduction filters in blood ...
- DOI:
- 10.1016/j.lfs.2019.03.072
- https://doi.org/10.1016/j.lfs.2019.03.072
- Author:
- Yanan Zhu; Gemma González-Ortiz; Rufino Jiménez-Díaz; Míriam Pérez-Trujillo; Teodor Parella; Paola López-Colom; Susana María Martín-Orúe
- Source:
- Food & function 2018 v.9 no.7 pp. 3884-3894
- ISSN:
- 2042-650X
- Subject:
- adhesion; arabinose; diarrhea; diet; enterotoxigenic Escherichia coli; exopolysaccharides; fermentation; fermented foods; fermenters; functional properties; galactose; glucose; humans; in vitro studies; intestinal mucosa; nuclear magnetic resonance spectroscopy; olives; pathogens; rhamnose; secondary infection
- Abstract:
- ... This study aims to explore the biological functions of the isolated exopolysaccharides (EPSs) produced during the industrial fermentation of olives against enterotoxigenic E. coli (ETEC) K88. Exopolysaccharides were isolated from five industrial fermenters. Analysis of their monosaccharide composition by GLC revealed that the main components were glucose (27%–50%) and galactose (23%–33%) followed ...
- DOI:
- 10.1039/c8fo00690c
- https://doi.org/10.1039/c8fo00690c
- Author:
- Prejit; Prakasam Thanka Pratheesh; Soman Nimisha; Vergis Jess; Karthikeyan Asha; Rajesh Kumar Agarwal
- Source:
- Biologicals 2019 v.62 pp. 22-26
- ISSN:
- 1045-1056
- Subject:
- Escherichia coli; Salmonella Typhimurium; Western blotting; foodborne illness; functional properties; genes; humans; inclusion bodies; molecular weight; nickel; nitrilotriacetic acid; outer membrane proteins; pathogens; polyacrylamide gel electrophoresis; poultry; poultry diseases; poultry products; protein synthesis; recombinant vaccines; rhamnose; salmonellosis
- Abstract:
- ... Salmonella is found to be a major causes of food borne diseases globally. Poultry products contaminated with this pathogen is one of the major sources of infections in humans. Outer membrane protein C (OmpC) of Salmonella Typhimurium is a promising DNA vaccine candidate to mitigate Salmonella infection in poultry. However, the large-scale production of bioactive recombinant OmpC (rOmpC) protein is ...
- DOI:
- 10.1016/j.biologicals.2019.10.010
- https://doi.org/10.1016/j.biologicals.2019.10.010
57. Food Wastes as a Potential New Source for Edible Insect Mass Production for Food and Feed: A review
- Author:
- Vassileios Varelas
- Source:
- Fermentation 2019 v.5 no.3 pp. -
- ISSN:
- 2311-5637
- Subject:
- Acheta domesticus; Hermetia illucens; Musca domestica; animal source protein; artificial diets; biofuels; byproducts; composts; edible insects; fermentation; food industry; food waste; functional properties; humans; life cycle assessment; livestock feeds; mass rearing; population growth
- Abstract:
- ... About one-third of the food produced annually worldwide ends up as waste. A minor part of this waste is used for biofuel and compost production, but most is landfilled, causing environmental damage. Mass production of edible insects for human food and livestock feed seems a sustainable solution to meet demand for animal-based protein, which is expected to increase due to rapid global population gr ...
- DOI:
- 10.3390/fermentation5030081
- https://doi.org/10.3390/fermentation5030081
- Author:
- Vasily Sukhorukov; Ivan Gudelj; Maja Pučić-Baković; Emile Zakiev; Alexander Orekhov; Anatol Kontush; Gordan Lauc
- Source:
- Biochimica et biophysica acta 2019 v.1864 no.5 pp. 643-653
- ISSN:
- 1388-1981
- Subject:
- cholesterol; cholesteryl esters; chromatography; functional properties; glycosylation; high density lipoprotein; humans; low density lipoprotein; matrix-assisted laser desorption-ionization mass spectrometry; sialic acid; sialidase
- Abstract:
- ... Human plasma lipoproteins are known to contain various glycan structures whose composition and functional importance are starting to be recognized. We assessed N-glycosylation of human plasma HDL and LDL and the role of their glycomes in cellular cholesterol metabolism.N-glycomic profiles of native and neuraminidase-treated HDL and LDL were obtained using HILIC-UHPLC-FLD. Relative abundance of the ...
- DOI:
- 10.1016/j.bbalip.2019.01.005
- https://doi.org/10.1016/j.bbalip.2019.01.005
- Author:
- D. Dalügge; S. Remy
- Source:
- Cell 2018 v.175 no.3 pp. 635-637
- ISSN:
- 0092-8674
- Subject:
- dendrites; functional properties; humans; models; rats
- Abstract:
- ... Most functional properties of human dendrites have been inferred from data obtained in model organisms. In this issue, Beaulieu-Laroche et al. record directly from human dendrites of cortical neurons and show that the considerably larger human neurons differ from rat neurons in the way they process synaptic signals. ...
- DOI:
- 10.1016/j.cell.2018.09.052
- https://doi.org/10.1016/j.cell.2018.09.052
- Author:
- Tolulope Joshua Ashaolu; Bandhita Saibandith; Chutha Takahashi Yupanqui; Santad Wichienchot
- Source:
- International journal of food science & technology 2019 v.54 no.1 pp. 141-148
- ISSN:
- 0950-5423
- Subject:
- Bifidobacterium; Lactobacillus; batch fermentation; branched chain fatty acids; digestive system; functional foods; functional properties; humans; intestinal microorganisms; markets; short chain fatty acids; soy protein hydrolysates; soy protein isolate
- Abstract:
- ... Several functional properties have been attributed to soy protein hydrolysates (SPHs); however, their gut fermentation needs to be investigated. This study aimed to determine the effect of hypo‐allergic pepsin‐educed SPH on the growth of gut microbiota, SCFA and BCFA production in a pH‐controlled, stirred, batch culture fermentation system compared with commercial SPH and soy protein isolate (SPI) ...
- DOI:
- 10.1111/ijfs.13916
- https://doi.org/10.1111/ijfs.13916
- Author:
- Brian E. Hew; David C. Fritzinger; Michael K. Pangburn; Carl-Wilhelm Vogel
- Source:
- Toxicon 2019 v.167 pp. 106-116
- ISSN:
- 0041-0101
- Subject:
- amino acid sequences; aspartic acid; blood serum; cobra venoms; complement; functional properties; histidine; humans; lysine; proteins
- Abstract:
- ... Cobra venom factor (CVF) is the complement-activating protein in cobra venom. CVF is a structural and functional analog of complement component C3. CVF, like C3b, forms a convertase with factor B. This bimolecular complex CVF,Bb is an enzyme that cleaves C3 and C5. However, CVF,Bb exhibits significantly different functional properties from C3b,Bb. The CVF,Bb convertase is physico-chemically very s ...
- DOI:
- 10.1016/j.toxicon.2019.06.017
- https://doi.org/10.1016/j.toxicon.2019.06.017
- Author:
- Ying Shi; Jianxin Zhao; Lee Kellingray; Hao Zhang; Arjan Narbad; Qixiao Zhai; Wei Chen
- Source:
- Food research international 2018 pp. -
- ISSN:
- 0963-9969
- Subject:
- Lactobacillus casei; Lactobacillus plantarum; carbohydrates; dairy products; duodenal juices; environmental factors; fermented foods; functional properties; genomics; humans; in vitro studies; in vivo studies; intestines; mice; multigene family; sequence analysis; survival rate
- Abstract:
- ... The presence of Lactobacillus strains in dairy products and the intestinal tracts of humans and animals is frequently considered to have beneficial effects on gut health. In this study, five L. plantarum and five L. casei strains from fermented food origin were isolated and compared to characterise their functional properties, including generation time, survival in the gastrointestinal environment ...
- DOI:
- 10.1016/j.foodres.2018.10.064
- https://doi.org/10.1016/j.foodres.2018.10.064
63. Insights into spatio-temporal dynamics of invertebrate communities from two alpine pasture ponds
- Author:
- Valeria Lencioni; Daniele Fattori; Gianluca Nardi; Leonardo Latella
- Source:
- Aquatic insects 2019 v.40 no.1 pp. 30-52
- ISSN:
- 1744-4152
- Subject:
- Coleoptera; Diptera; Heteroptera; Tubificidae; data collection; drought tolerance; fauna; functional properties; humans; hydrology; insects; livestock; macroinvertebrates; meteorological parameters; pastures; ponds; sediments; species diversity; vegetation cover
- Abstract:
- ... This study aimed to characterise the composition, structure and trophic organisation of the macroinvertebrate communities of two pasture ponds – one natural and one artificial – in the Italian Prealps. Faunal composition was studied during the snow-free period in 2003–2004 and compared with data collected in 1984–1985. Insects (i.e., Coleoptera, Diptera and Heteroptera) prevailed (58%), followed b ...
- DOI:
- 10.1080/01650424.2018.1523434
- https://doi.org/10.1080/01650424.2018.1523434
- Author:
- Olga O. Udartseva; Olga V. Zhidkova; Maria I. Ezdakova; Irina V. Ogneva; Elena R. Andreeva; Ludmila B. Buravkova; Sandra O. Gollnick
- Source:
- Journal of photochemistry and photobiology 2019 pp. -
- ISSN:
- 1011-1344
- Subject:
- angiogenesis; cell movement; chemokine CCL2; coculture; cytoskeleton; functional properties; humans; immunogenicity; interleukin-8; irradiation; lymphocytes; macrophages; mesenchymal stromal cells; mitogen-activated protein kinase; models; neoplasms; photochemotherapy; reactive oxygen species; secretion; vascular endothelial growth factor A; viability
- Abstract:
- ... Photodynamic therapy (PDT) is a non-invasive FDA and EMA-approved anticancer treatment modality. Initially developed for elimination of malignant cells, PDT affects all cells in the tumor bed including stromal cells. Stroma represents not only an important component of tumor microenvironment, but has a significant impact on tumor susceptibility to PDT and other anticancer therapies. However, the e ...
- DOI:
- 10.1016/j.jphotobiol.2019.111596
- https://doi.org/10.1016/j.jphotobiol.2019.111596
- Author:
- Habib Mosbah; Hassiba Chahdoura; Khaoula Adouni; Jannet Kamoun; Mohamed Ali Boujbiha; Ana M. Gonzalez‐Paramas; Celestino Santos‐Buelga; María Ciudad‐Mulero; Patricia Morales; Virginia Fernández‐Ruiz; Lotfi Achour; Boulbaba Selmi
- Source:
- Journal of food biochemistry 2019 v.43 no.11 pp. e13012
- ISSN:
- 0145-8884
- Subject:
- Acca sellowiana; Alzheimer disease; acetylcholinesterase; chronic diseases; dietary fiber; diodes; enzyme inhibition; enzyme kinetics; fatty acids; flavanols; functional properties; glycosides; high performance liquid chromatography; humans; leaf extracts; leaves; mass spectrometry; mineral content; nutritive value; obesity; phenolic acids; procyanidins; proteins; quercetin; tea (beverage); traditional medicine; triacylglycerol lipase
- Abstract:
- ... The nutritional values, the identification of individual phenolic compounds as well as the functional properties (in vitro acetylcholinesterase (AChE) and pancreatic lipase inhibition) of Tunisian Feijoa sellowiana (O.Berg) leaves were determined by high‐performance liquid chromatography coupled with diode array and mass spectrometry detector. Feijoa Sellowiana leaves Extract (FSLE) were evaluated ...
- DOI:
- 10.1111/jfbc.13012
- https://doi.org/10.1111/jfbc.13012
- Author:
- Jesica G. Mild; Lucia R. Fernandez; Odile Gayet; Juan Iovanna; Nelson Dusetti; Martin M. Edreira
- Source:
- Molecular biotechnology 2018 v.60 no.5 pp. 369-379
- ISSN:
- 1073-6085
- Subject:
- Chagas disease; Trypanosoma cruzi; bioluminescence; energy; functional properties; humans; messenger RNA; new drugs; parasites; protein-protein interactions; proteins; public health; screening; South America
- Abstract:
- ... Chagas disease, a parasitic disease caused by Trypanosoma cruzi, is a major public health burden in poor rural populations of Central and South America and a serious emerging threat outside the endemic region, since the number of infections in non-endemic countries continues to rise. In order to develop more efficient anti-trypanosomal treatments to replace the outdated therapies, new molecular ta ...
- DOI:
- 10.1007/s12033-018-0078-3
- https://doi.org/10.1007/s12033-018-0078-3
67. Pacemaker cell characteristics of differentiated and HCN4-transduced human mesenchymal stem cells
- Author:
- Fabrice F. Darche; Rasmus Rivinius; Eva Köllensperger; Uwe Leimer; Günter Germann; Anja Seckinger; Dirk Hose; Julian Schröter; Claus Bruehl; Andreas Draguhn; Richard Gabriel; Manfred Schmidt; Michael Koenen; Dierk Thomas; Hugo A. Katus; Patrick A. Schweizer
- Source:
- Life sciences 2019 v.232 pp. 116620
- ISSN:
- 0024-3205
- Subject:
- adverse effects; biological clocks; coculture; confocal microscopy; connexins; functional properties; genes; humans; hydrogen cyanide; image analysis; immunocytochemistry; ion channels; mesenchymal stromal cells; myocytes; phenotype; rats; reverse transcriptase polymerase chain reaction; transcription (genetics); transcription factors
- Abstract:
- ... Cell-based biological pacemakers aim to overcome limitations and side effects of electronic pacemaker devices. We here developed and tested different approaches to achieve nodal-type differentiation using human adipose- and bone marrow-derived mesenchymal stem cells (haMSC, hbMSC).haMSC and hbMSC were differentiated using customized protocols. Quantitative RT-PCR was applied for transcriptional pa ...
- DOI:
- 10.1016/j.lfs.2019.116620
- https://doi.org/10.1016/j.lfs.2019.116620
- Author:
- Mengmeng Duan; Xiaona Sun; Na Ma; Yili Liu; Tengrui Luo; Shuang Song; Chunqing Ai
- Source:
- International journal of biological macromolecules 2019 v.121 pp. 996-1004
- ISSN:
- 0141-8130
- Subject:
- Bacteroidetes; Saccharina japonica; adipose tissue; animal models; body composition; dietary supplements; functional properties; humans; intestinal microorganisms; intestines; liver; metabolic syndrome; metabolites; mice; nutrient utilization; obesity; polysaccharides
- Abstract:
- ... Polysaccharides from Laminaria japonica (LJPs) are reported to have various functional properties, but the effects and mechanisms of LJPs on obesity and its related diseases are unclear. This study demonstrated that LJPs prevented diet-induced obesity in a mice model, and improved obesity-related parameters, e.g. fat accumulation in the liver and adipose tissues, body composition, lipids profile, ...
- DOI:
- 10.1016/j.ijbiomac.2018.10.087
- https://doi.org/10.1016/j.ijbiomac.2018.10.087
- Author:
- Mostafa Nasr; Mohamed Farghaly; Tarek Elsaba; Mohamed El-Mokhtar; Radwa Radwan; Mahmoud Elsabahy; Ahmed Abdelkareem; Hussein Fakhry; Noha Mousa
- Source:
- international journal of biochemistry & cell biology 2018 v.105 pp. 84-93
- ISSN:
- 1357-2725
- Subject:
- acetates; acute exposure; antagonists; bone formation; breast neoplasms; carcinogenesis; clinical trials; cytotoxicity; drug therapy; encapsulation; estradiol; females; functional properties; gene overexpression; humans; metastasis; nanoparticles; neoplasm cells; phenotype; progesterone; stem cells; steroid hormones; women
- Abstract:
- ... Female sex steroid hormones have a fundamental role in breast cancer. Meanwhile, current evidence supports the contribution of breast cancer stem cells in carcinogenesis, metastasis, and resistance to cytotoxic chemotherapy. Nevertheless, the interaction between breast cancer stem cells with sex hormones or key hormonal antagonists remains elusive.To investigate the effect of diverse sex hormonal ...
- DOI:
- 10.1016/j.biocel.2018.10.005
- https://doi.org/10.1016/j.biocel.2018.10.005
- Author:
- S. Lalitha Gavya; Neha Arora; Siddhartha Sankar Ghosh
- Source:
- Preparative biochemistry & biotechnology 2018 v.48 no.2 pp. 128-135
- ISSN:
- 1532-2297
- Subject:
- NAD (coenzyme); Western blotting; biomarkers; chromatography; circular dichroism spectroscopy; functional properties; glutathione transferase; humans; lactate dehydrogenase; lactic acid; neoplasms; pH; proteins; temperature
- Abstract:
- ... A paradigm shift toward fusion proteins to render multiple functionalities and applications on a single platform has been incurred in enzyme based diagnosis. Herein, we report development and systematic characterizations of glutathione-S-transferase (GST) and human lactate dehydrogenase A (hLDHA) in a fusion protein (GST–hLDHA) to achieve functional activities of GST and hLDHA simultaneously. The ...
- DOI:
- 10.1080/10826068.2017.1405022
- https://doi.org/10.1080/10826068.2017.1405022
- Author:
- Khaoula Adouni; Hassiba Chahdoura; Habib Mosbah; Celestino Santos-Buelga; Ana M. González-Paramás; María Ciudad-Mulero; Ângela Fernandes; Ricardo C. Calhelha; Patricia Morales; Guido Flamini; Isabel C. F. R. Ferreira; Lotfi Achour
- Source:
- Food & function 2018 v.9 no.3 pp. 1578-1586
- ISSN:
- 2042-650X
- Subject:
- antioxidants; chemical constituents of plants; chromatography; dietary fiber; functional properties; glycerol; human cell lines; humans; in vitro studies; liquids; neoplasm cells; nutrients; nutritive value; shoots; spectrometers; vegetables; wild plants; Tunisia
- Abstract:
- ... The nutritional values and phytochemical composition of young shoots of wild Asparagus stipularis Forssk. from Tunisia were determined in this study. The antioxidant (tested by four different in vitro assays) and antiproliferative properties (against human tumour cell lines) of aqueous and hydroalcoholic extracts of the young shoots were also investigated. The obtained results indicated that the y ...
- DOI:
- 10.1039/c7fo01687e
- https://doi.org/10.1039/c7fo01687e
- Author:
- Anita Katekhaye
- Source:
- Agricultural reviews 2019 v.40 no.2 pp. 150-156
- ISSN:
- 0976-0741
- Subject:
- breast meat; broiler chickens; chicken industry; chicken meat; functional properties; genotype; humans; meat quality; nutritive value; polyunsaturated fatty acids; sensory properties; India
- Abstract:
- ... India is the fourth largest chicken producer after China, Brazil, and the USA. The per capita consumption of chicken has gone up from 400 gm–2.5 kg per year, and human nutritionists recommend 10 kg chicken per year. To feed billions of Indian population, there is a lot of scope for the chicken industry to enhance the production. At the same time, many studies revealed that genotype significantly a ...
- DOI:
- 10.18805/ag.R-1863
- https://doi.org/10.18805/ag.R-1863
- Author:
- Atefe Maghsoudlou; Alireza Sadeghi Mahoonak; Hossein Mohebodini; Fidel Toldra
- Source:
- Journal of apicultural science 2019 v.63 no.1 pp. 17-40
- ISSN:
- 2299-4831
- Subject:
- Apis mellifera; acetylcholine; adenosine; adenosine monophosphate; anaphylaxis; anti-aging properties; anti-inflammatory activity; antibacterial properties; antihypertensive effect; antioxidant activity; asthma; bioactive compounds; blood; carbohydrates; diabetes; dietary supplements; estradiol; flavonoids; functional properties; humans; ingredients; lipids; liver; mandibular glands; minerals; polyphenols; progesterone; prolactin; proteins; reproductive system; royal jelly; shelf life; testosterone; tissue repair; vitamins; worker honey bees
- Abstract:
- ... Royal jelly (RJ) has been known for centuries, but in the last 5-6 decades its systematic production and consumption has increased. RJ is secreted by the hypopharyngeal and mandibular glands of worker honeybees (Apis mellifera). This thick and milky substance contains water, proteins, carbohydrates, lipids, minerals, vitamins and such bio-active compounds as acetylcholine, peptides, the hormones t ...
- DOI:
- 10.2478/jas-2019-0007
- https://doi.org/10.2478/jas-2019-0007
- Author:
- Abirami R. Ganesan; Uma Tiwari; Gaurav Rajauria
- Source:
- Food science and human wellness 2019 v.8 no.3 pp. 252-263
- ISSN:
- 2213-4530
- Subject:
- anticoagulant activity; antioxidant activity; bioactive compounds; bioavailability; biocompatibility; disease prevention; fatty acids; functional foods; functional properties; humans; macroalgae; metabolism; models; peptides; pigments; polyphenols; polysaccharides; secondary metabolites; therapeutics
- Abstract:
- ... There is a growing interest that bioactive compounds from seaweed can play a major therapeutic role in disease prevention in humans. Seaweed bioactives including polysaccharides, pigments, fatty acids, polyphenols and peptides have been proven to possess various beneficial biological properties that could potentially contribute to functional food and nutraceutical development. These bioactive are ...
- DOI:
- 10.1016/j.fshw.2019.08.001
- https://doi.org/10.1016/j.fshw.2019.08.001
- Author:
- Arpita Mohapatra; Ajay Kumar Shinde; Raghvendar Singh
- Source:
- Small ruminant research 2019 v.181 pp. 6-11
- ISSN:
- 0921-4488
- Subject:
- dairy sheep; developing countries; digestive system; eczema; ewe milk; fatty acids; functional foods; functional properties; health promotion; households; human health; human nutrition; humans; immunoglobulins; lifestyle; milk; milk proteins; peptides; prebiotics; probiotics; protein content; psoriasis; risk reduction; sheep; soaps
- Abstract:
- ... Modern human diet and changes in lifestyle are emerging as a challenge in developing countries resulting to endless ailments. Thus, in modern spectra of human health, bioactive foods play a pivotal role. Under the umbrella of food and nutrition security, functional dairy foods have become the need of the hour. Sheep milk is one of the functionally active dairy foods and it is also considered as nu ...
- DOI:
- 10.1016/j.smallrumres.2019.10.002
- https://doi.org/10.1016/j.smallrumres.2019.10.002
- Author:
- Andrei Mocan; Cadmiel Moldovan; Gökhan Zengin; Onur Bender; Marcello Locatelli; Mario Simirgiotis; Arzu Atalay; Dan Cristian Vodnar; Sascha Rohn; Gianina Crișan
- Source:
- Food and chemical toxicology 2018 v.115 pp. 414-424
- ISSN:
- 0278-6915
- Subject:
- foods; flavonoids; dietary supplements; risk; dose response; toxicology; enzyme inhibition; cultivars; humans; small fruits; cytotoxicity; spermidine; bioactive compounds; antioxidant activity; antioxidants; oxylipins; Lycium barbarum; kidney cells; phenolic acids; healthy diet; functional properties
- Abstract:
- ... Goji (Lycium barbarum L.) berries are emphasized as healthy food or are used widely as dietary supplements. In the present study, the antioxidant and enzyme inhibitory activities of berries extracts from two selected Romanian cultivars (cv. Erma and cv. Biglifeberry) have been evaluated. UHPLC-QTOF-MS analysis results revealed the presence of organic acids, phenolic acids, flavonoids, fatty acids ...
- DOI:
- 10.1016/j.fct.2018.01.054
- https://doi.org/10.1016/j.fct.2018.01.054
- Author:
- Weisi Lu; Xuri Li
- Source:
- Cellular and molecular life sciences 2018 v.75 no.5 pp. 859-869
- ISSN:
- 1420-682X
- Subject:
- blood; blood vessels; bone marrow; eye diseases; functional properties; humans; pathophysiology; physiology; signal transduction; smooth muscle; stem cells
- Abstract:
- ... Vascular stem/progenitor cells (VSCs) are an important source of all types of vascular cells needed to build, maintain, repair, and remodel blood vessels. VSCs, therefore, play critical roles in the development, normal physiology, and pathophysiology of numerous diseases. There are four major types of VSCs, including endothelial progenitor cells (EPCs), smooth muscle progenitor cells (SMPCs), peri ...
- DOI:
- 10.1007/s00018-017-2662-2
- https://doi.org/10.1007/s00018-017-2662-2
- Author:
- V. Ramya; N. K. Jain
- Source:
- Journal of food process engineering 2017 v.40 no.3 pp. -
- ISSN:
- 0145-8876
- Subject:
- agitation; blanching; chemical elements; coatings; color; drying; electric field; energy; energy conservation; engineering; foods; fruits; functional properties; high pressure treatment; humans; mass transfer; mathematical models; mixing; nutrient content; odors; osmosis; osmotic treatment; solutes; temperature; texture; ultrasonic treatment; vegetables
- Abstract:
- ... Osmotic dehydration is a simultaneous mass transfer process which mainly promotes the flow of water molecules from the food to osmo‐active solution and some migration of solutes from the solution into the food, thus maintaining good organoleptic and functional properties in the finished product. This paper presents mechanism of osmotic dehydration and recent developments regarding the factors affe ...
- DOI:
- 10.1111/jfpe.12440
- https://doi.org/10.1111/jfpe.12440
- Author:
- Marie Louise Jahn; Maria Abildgaard Steffensen; Jan Pravsgaard Christensen; Allan Randrup Thomsen
- Source:
- Vaccine 2018 v.36 no.20 pp. 2825-2832
- ISSN:
- 0264-410X
- Subject:
- CD8-positive T-lymphocytes; Listeria monocytogenes; antigens; functional properties; glycoproteins; humans; immunity; longevity; phenotype; phenotypic plasticity; serotypes; vaccination; vaccines
- Abstract:
- ... Defining correlates of T cell mediated protection is important in order to accelerate the development of efficient T cell based vaccines conferring long-term immunity.Extensive studies have provided important insight regarding the characteristics and functional properties of the effector and memory CD8 T cells induced by viral vector based vaccines. However, long-term protection has been difficult ...
- DOI:
- 10.1016/j.vaccine.2018.03.080
- https://doi.org/10.1016/j.vaccine.2018.03.080
- Author:
- Irina Rosca; Anca Roxana Petrovici; Dragos Peptanariu; Alina Nicolescu; Gianina Dodi; Mihaela Avadanei; Iuliu Cristian Ivanov; Andra Cristina Bostanaru; Mihai Mares; Diana Ciolacu
- Source:
- International journal of biological macromolecules 2018 v.107 pp. 1765-1772
- ISSN:
- 0141-8130
- Subject:
- Candida albicans; Fourier transform infrared spectroscopy; UHT milk; Weissella confusa; antibacterial properties; biofilm; biosynthesis; culture media; cytotoxicity; dextran; drugs; exopolysaccharides; fermentation; fibroblasts; freeze drying; functional properties; humans; hydrophilicity; lactic acid bacteria; nuclear magnetic resonance spectroscopy; nucleotide sequences; pharmaceutical industry; polymers; ribosomal DNA; sucrose; thermal analysis
- Abstract:
- ... The aim of this study was to monitor the influence of the fermentation conditions on the exopolysaccharides (EPS) biosynthesis. For this, different culture media compositions were tested on an isolated lactic acid bacteria (LAB) strain, identified by 16S rDNA sequence as being Weissella confusa. It was proved that this bacterial strain culture in MRS medium supplemented with 80g/L sucrose and diss ...
- DOI:
- 10.1016/j.ijbiomac.2017.10.048
- https://doi.org/10.1016/j.ijbiomac.2017.10.048
- Author:
- Thao Thi Nguyen; Tae-Soo Chon; Jaehan Kim; Young-Su Seo; Muyoung Heo
- Source:
- journal of microbiology 2017 v.55 no.7 pp. 568-582
- ISSN:
- 1225-8873
- Subject:
- Burkholderia glumae; Markov chain; bioinformatics; blight; data collection; functional properties; hosts; humans; hydrophobicity; inflorescences; mass spectrometry; pathogenesis; plant pathogens; protein secretion; proteins; rice; seedlings
- Abstract:
- ... Secreted proteins (secretomes) play crucial roles during bacterial pathogenesis in both plant and human hosts. The identification and characterization of secretomes in the two plant pathogens Burkholderia glumae BGR1 and B. gladioli BSR3, which cause diseases in rice such as seedling blight, panicle blight, and grain rot, are important steps to not only understand the disease-causing mechanisms bu ...
- DOI:
- 10.1007/s12275-017-7085-0
- https://doi.org/10.1007/s12275-017-7085-0
- Author:
- Astrid Borchert; Jacqueline Kalms; Sophia R. Roth; Marlena Rademacher; Andrea Schmidt; Hermann-Georg Holzhutter; Hartmut Kuhn; Patrick Scheerer
- Source:
- Biochimica et biophysica acta 2018 v.1863 no.9 pp. 1095-1107
- ISSN:
- 1388-1981
- Subject:
- Escherichia coli; X-radiation; alcohols; crystal structure; electrophoresis; enzymology; functional properties; genes; glutathione; glutathione peroxidase; humans; hydroperoxides; mice; phospholipid-hydroperoxide glutathione peroxidase; phospholipids; reaction mechanisms; selenium; selenocysteine; selenoproteins; transgenic animals
- Abstract:
- ... Glutathione peroxidases (GPX) are anti-oxidative enzymes that reduce organic and inorganic hydroperoxides to the corresponding alcohols at the expense of reduced glutathione. The human genome involves eight GPX genes and five of them encode for selenocysteine-containing enzymes. Among the human GPX-isoforms, GPX4 is unique since it is capable of reducing complex hydroperoxy ester lipids such as hy ...
- DOI:
- 10.1016/j.bbalip.2018.06.006
- https://doi.org/10.1016/j.bbalip.2018.06.006
- Author:
- Agata Los; Dana Ziuzina; Paula Bourke
- Source:
- Journal of food science 2018 v.83 no.6 pp. 1484-1493
- ISSN:
- 0022-1147
- Subject:
- decontamination; food safety; functional properties; human health; humans; microorganisms; mycotoxins; pesticides; population growth; risk; small cereal grains; staple foods
- Abstract:
- ... Cereal grains are the most important staple foods for mankind worldwide. The constantly increasing annual production and yield is matched by demand for cereals, which is expected to increase drastically along with the global population growth. A critical food safety and quality issue is to minimize the microbiological contamination of grains as it affects cereals both quantitatively and qualitativ ...
- DOI:
- 10.1111/1750-3841.14181
- https://doi.org/10.1111/1750-3841.14181
- Author:
- J.M.B. Prieto; M.J.B. Felippe
- Source:
- Comparative immunology, microbiology, and infectious diseases 2017 v.54 pp. 38-44
- ISSN:
- 0147-9571
- Subject:
- B-lymphocytes; Primates; adaptive immunity; autoimmune diseases; cattle; functional properties; guinea pigs; homeostasis; horses; humans; immunoglobulin M; innate immunity; mice; phenotype; rabbits; secretion; swine; tissue distribution
- Abstract:
- ... Three populations of B cells develop in fetal life: B1, B2 and marginal zone B cells. B1 cells play important roles in innate immunity in contrast to B2 cells that perform the conventional roles in adaptive immunity. B1 cells were first identified in mice based on their expression of CD5 and spontaneous secretion of IgM. B1 cells were subsequently found to have unique developmental, phenotype, tis ...
- DOI:
- 10.1016/j.cimid.2017.08.002
- https://doi.org/10.1016/j.cimid.2017.08.002
- Author:
- Zeinab Heidariyan; Mohammad Hossein Ghanian; Mohsen Ashjari; Zahra Farzaneh; Mostafa Najarasl; Mehran Rezaei Larijani; Abbas Piryaei; Massoud Vosough; Hossein Baharvand
- Source:
- Biomaterials 2018 v.159 pp. 174-188
- ISSN:
- 0142-9612
- Subject:
- animal models; bioreactors; cost effectiveness; functional properties; gene expression; growth factors; humans; liver diseases; microparticles; polylactic acid; stem cells; ultrastructure
- Abstract:
- ... Biomedical application of human pluripotent stem cell-derived hepatocyte-like cells (hPSC-HLCs) relies on efficient large-scale differentiation, which is commonly performed by a suspension culture of three-dimensional (3D) multicellular spheroids in bioreactors. However, this approach requires large amounts of growth factors (GFs) and the need to overcome limited diffusional transport posed by the ...
- DOI:
- 10.1016/j.biomaterials.2018.01.005
- https://doi.org/10.1016/j.biomaterials.2018.01.005
- Author:
- Thomas E. Kutcher; Graham E. Forrester
- Source:
- Journal of environmental management 2018 v.217 pp. 231-239
- ISSN:
- 0301-4797
- Subject:
- biological assessment; ecosystem management; ecosystems; freshwater; functional properties; habitat destruction; humans; indicator species; indigenous species; introduced species; models; sampling; species abundance; species richness; vegetation; wetlands
- Abstract:
- ... Biological indicators are useful tools for the assessment of ecosystem condition. Multi-metric and multi-taxa indicators may respond to a broader range of disturbances than simpler indicators, but their complexity can make them difficult to interpret, which is critical to indicator utility for ecosystem management. Floristic Quality Assessment (FQA) is an example of a biological assessment approac ...
- DOI:
- 10.1016/j.jenvman.2018.03.093
- https://doi.org/10.1016/j.jenvman.2018.03.093
- Author:
- Kakali Biswas; Debarun Acharya; Soumita Podder; Tapash Chandra Ghosh
- Source:
- Genomics 2017 pp. -
- ISSN:
- 0888-7543
- Subject:
- functional properties; gene expression; humans; microRNA; protein-protein interactions; proteins; regression analysis
- Abstract:
- ... Integrating gene expression into protein-protein interaction network (PPIN) leads to the construction of tissue-specific (TS) and housekeeping (HK) sub-networks, with distinctive TS- and HK-hubs. All such hub proteins are divided into multi-interface (MI) hubs and single-interface (SI) hubs, where MI hubs evolve slower than SI hubs. Here we explored the evolutionary rate difference between MI and ...
- DOI:
- 10.1016/j.ygeno.2017.11.006
- https://doi.org/10.1016/j.ygeno.2017.11.006
- Author:
- James P. W. Robinson; Ivor D. Williams; Andrew M. Edwards; Jana McPherson; Lauren Yeager; Laurent Vigliola; Russell E. Brainard; Julia K. Baum
- Source:
- Global change biology 2017 v.23 no.3 pp. 1009-1022
- ISSN:
- 1354-1013
- Subject:
- aquatic ecosystems; biogeography; biomass; community structure; coral reefs; fish; fish communities; fisheries; functional properties; human population; humans; islands; markets; surface water temperature; Pacific Ocean Islands
- Abstract:
- ... Fishing pressure on coral reef ecosystems has been frequently linked to reductions of large fishes and reef fish biomass. Associated impacts on overall community structure are, however, less clear. In size‐structured aquatic ecosystems, fishing impacts are commonly quantified using size spectra, which describe the distribution of individual body sizes within a community. We examined the size spect ...
- DOI:
- 10.1111/gcb.13482
- https://doi.org/10.1111/gcb.13482
- Author:
- Maria L Marco; Dustin Heeney; Sylvie Binda; Christopher J Cifelli; Paul D Cotter; Benoit Foligné; Michael Gänzle; Remco Kort; Gonca Pasin; Anne Pihlanto; Eddy J Smid; Robert Hutkins
- Source:
- Current opinion in biotechnology 2017 v.44 pp. 94-102
- ISSN:
- 0958-1669
- Subject:
- beers; clinical trials; fermented sausages; functional properties; genetic similarity; humans; kimchi; probiotics; sauerkraut; sensory properties; shelf life; wines; yogurt
- Abstract:
- ... Fermented foods and beverages were among the first processed food products consumed by humans. The production of foods such as yogurt and cultured milk, wine and beer, sauerkraut and kimchi, and fermented sausage were initially valued because of their improved shelf life, safety, and organoleptic properties. It is increasingly understood that fermented foods can also have enhanced nutritional and ...
- DOI:
- 10.1016/j.copbio.2016.11.010
- https://doi.org/10.1016/j.copbio.2016.11.010
- Author:
- Panagiotis G. Adamopoulos; Christos K. Kontos; Andreas Scorilas
- Source:
- Biochemical and biophysical research communications 2017 pp. -
- ISSN:
- 0006-291X
- Subject:
- bioinformatics; metastasis; neoplasms; biomarkers; rapid amplification of cDNA ends; transcriptome; tissue kallikrein; tissues; apoptosis; messenger RNA; alternative splicing; complementary DNA; humans; high-throughput nucleotide sequencing; molecular cloning; exons; disease diagnosis; reverse transcriptase polymerase chain reaction; functional properties; cell cycle
- Abstract:
- ... Kallikreins (KLKs) form the largest group of serine proteases in the human genome sharing many structural and functional characteristics. Multiple alternative transcripts have been reported for most human KLKs, while many of them have been found aberrantly expressed in various human malignancies, thus possessing significant prognostic or/and diagnostic value. Alternative splicing of cancer-related ...
- DOI:
- 10.1016/j.bbrc.2017.04.078
- https://doi.org/10.1016/j.bbrc.2017.04.078
91. Integrative analysis of the Lake Simcoe watershed (Ontario, Canada) as a socio-ecological system
- Author:
- Alex Neumann; Dong-Kyun Kim; Gurbir Perhar; George B. Arhonditsis
- Source:
- Journal of environmental management 2017 v.188 pp. 308-321
- ISSN:
- 0301-4797
- Subject:
- environmental programs; functional properties; humans; hydrology; interdisciplinary research; lakes; landscapes; population density; research methods; socioeconomics; subwatersheds; urbanization; watershed management; Ontario
- Abstract:
- ... Striving for long-term sustainability in catchments dominated by human activities requires development of interdisciplinary research methods to account for the interplay between environmental concerns and socio-economic pressures. In this study, we present an integrative analysis of the Lake Simcoe watershed, Ontario, Canada, as viewed from the perspective of a socio-ecological system. Key feature ...
- DOI:
- 10.1016/j.jenvman.2016.11.073
- https://doi.org/10.1016/j.jenvman.2016.11.073
- Author:
- Ivan Mihaljević; Marta Popović; Roko Žaja; Nikola Maraković; Goran Šinko; Tvrtko Smital
- Source:
- Aquatic toxicology 2017 v.187 pp. 18-28
- ISSN:
- 0166-445X
- Subject:
- 4',6-diamidino-2-phenylindole; Danio rerio; absorption; active sites; berberine; cation pumps; cations; cimetidine; cisplatin; cytotoxicity; ecotoxicology; ethidium; excretion; fluorescence; functional properties; heterologous gene expression; humans; inhibitory concentration 50; kidney cells; metabolism; models; paraquat; pyrimethamine; solutes; steroid hormones; tissues; topology; xenobiotics
- Abstract:
- ... Organic cation transporters (OCTs) serve as uptake transporters of numerous endo- and xenobiotics. They have been in the focus of medical toxicological research for more than a decade due to their key role in absorption, distribution, metabolism and excretion due to their expression on basolateral membranes of various barrier tissues. OCTs belong to the SLC22A family within the SLC (Solute carrier ...
- DOI:
- 10.1016/j.aquatox.2017.03.012
- https://doi.org/10.1016/j.aquatox.2017.03.012
- Author:
- Ahmed Ghannam; Hossam Murad; Marie Jazzara; Adnan Odeh; Abdul Wahab Allaf
- Source:
- International journal of biological macromolecules 2018 v.108 pp. 916-926
- ISSN:
- 0141-8130
- Subject:
- Fourier transform infrared spectroscopy; Laurencia; apoptosis; breast neoplasms; cell viability; cell walls; cytotoxicity; dose response; functional properties; humans; hydrocolloids; lambda-carrageenan; macroalgae; molecular weight; neoplasm cells; nuclear magnetic resonance spectroscopy; therapeutics
- Abstract:
- ... Hydrocolloids from seaweeds (phycocolloids) have interesting functional properties like antiproliferative activity. Marine algae consumptions are linked to law cancer incidences in countries that traditionally consume marine products. In this study, we have investigated water-soluble sulfated polysaccharides isolated from the red seaweed Laurencia papillosa and determined their chemical characteri ...
- DOI:
- 10.1016/j.ijbiomac.2017.11.001
- https://doi.org/10.1016/j.ijbiomac.2017.11.001
- Author:
- Rashmi Parihar; Anupama Rai; Subramaniam Ganesh
- Source:
- Journal of genetics 2018 v.97 no.3 pp. 611-624
- ISSN:
- 0022-1333
- Subject:
- adolescence; animal models; autophagy; biochemical pathways; childhood; cognitive disorders; death; epilepsy; functional properties; genes; genetic disorders; genotype; glycogen; humans; inflammation; neurodegenerative diseases; neurons; patients; phenotype; proteins; proteolysis; seizures; therapeutics; tissues; ubiquitin-protein ligase
- Abstract:
- ... The progressive myoclonic epilepsy of Lafora or Lafora disease (LD) is a neurodegenerative disorder characterized by recurrent seizures and cognitive deficits. With typical onset in the late childhood or early adolescence, the patients show progressive worsening of the disease symptoms, leading to death in about 10 years. It is an autosomal recessive disorder caused by the loss-of-function mutatio ...
- DOI:
- 10.1007/s12041-018-0949-1
- https://doi.org/10.1007/s12041-018-0949-1
- Author:
- S. Wurth; M. Capogrosso; S. Raspopovic; J. Gandar; G. Federici; N. Kinany; A. Cutrone; A. Piersigilli; N. Pavlova; R. Guiet; G. Taverni; J. Rigosa; P. Shkorbatova; X. Navarro; Q. Barraud; G. Courtine; S. Micera
- Source:
- Biomaterials 2017 v.122 pp. 114-129
- ISSN:
- 0142-9612
- Subject:
- giant cells; peripheral nerves; humans; nerve fibers; muscles; macrophages; electrodes; sensation; encapsulation; functional properties; rats; algorithms; biocompatibility; adults; nerve tissue
- Abstract:
- ... Stimulation of peripheral nerves has transiently restored lost sensation and has the potential to alleviate motor deficits. However, incomplete characterization of the long-term usability and bio-integration of intra-neural implants has restricted their use for clinical applications. Here, we conducted a longitudinal assessment of the selectivity, stability, functionality, and biocompatibility of ...
- DOI:
- 10.1016/j.biomaterials.2017.01.014
- https://doi.org/10.1016/j.biomaterials.2017.01.014
- Author:
- Jagan Mohan Rao Tingirikari
- Source:
- Food & function 2018 v.9 no.10 pp. 5059-5073
- ISSN:
- 2042-650X
- Subject:
- acids; arabinans; arabinogalactans; bacteria; colon; dietary fiber; food industry; functional properties; gastric juice; humans; hydrolysis; ingredients; intestinal microorganisms; oligosaccharides; pectins; prebiotics
- Abstract:
- ... Diverse human intestinal microbiota are regarded as a prerequisite for a healthy intestine. Commercial prebiotic products have a limited ability to provide microbial diversity in the human gut, because they mostly comprise oligomers of the same monosaccharide residues and a small fraction of them can reach the distal colon. Therefore, the demand for diverse prebiotic ingredients and dietary fibers ...
- DOI:
- 10.1039/c8fo01296b
- https://doi.org/10.1039/c8fo01296b
- Author:
- Serena Viventi; Mirella Dottori
- Source:
- international journal of biochemistry & cell biology 2018 v.100 pp. 61-68
- ISSN:
- 1357-2725
- Subject:
- cell lines; fibroblasts; functional properties; humans; models; muscles; neurodegenerative diseases; pain; peripheral nervous system diseases; rodents; sensory neurons; sensory system; stem cells; temperature; vibration
- Abstract:
- ... Sensory neurons of the dorsal root ganglia (DRG) are the primary responders to stimuli inducing feelings of touch, pain, temperature, vibration, pressure and muscle tension. They consist of multiple subpopulations based on their morphology, molecular and functional properties. Our understanding of DRG sensory neurons has been predominantly driven by rodent studies and using transformed cell lines, ...
- DOI:
- 10.1016/j.biocel.2018.05.005
- https://doi.org/10.1016/j.biocel.2018.05.005
98. Multimodal highly fluorescent-magnetic nanoplatform to target transferrin receptors in cancer cells
- Author:
- Paulo E. Cabral Filho; Mariana P. Cabrera; Ana L.C. Cardoso; Otacilio A. Santana; Carlos F.G.C. Geraldes; Beate S. Santos; Maria C. Pedroso de Lima; Giovannia A.L. Pereira; Adriana Fontes
- Source:
- Biochimica et biophysica acta 2018 v.1862 no.12 pp. 2788-2796
- ISSN:
- 0304-4165
- Subject:
- chemical bonding; fluorescence; fluorescence emission spectroscopy; functional properties; human cell lines; humans; in vivo studies; magnetic resonance imaging; nanoparticles; neoplasm cells; neoplasms; quantum dots; receptors; therapeutics; transferrin receptors
- Abstract:
- ... Site-specific multimodal nanoplatforms with fluorescent-magnetic properties have great potential for biological sciences. For this reason, we developed a multimodal nanoprobe (BNPs-Tf), by covalently conjugating an optical-magnetically active bimodal nanosystem, based on quantum dots and iron oxide nanoparticles, with the human holo-transferrin (Tf).The Tf bioconjugation efficiency was evaluated b ...
- DOI:
- 10.1016/j.bbagen.2018.08.014
- https://doi.org/10.1016/j.bbagen.2018.08.014
- Author:
- Yasaman Etemadian; Bahareh Shabanpour; Zohreh Ramzanpour; Amir Reza Shaviklo; Moazameh Kordjazi
- Source:
- Journal of aquatic food product technology 2018 v.27 no.2 pp. 219-235
- ISSN:
- 1547-0636
- Subject:
- Fourier transform infrared spectroscopy; Phaeophyceae; absorption; alanine; antibacterial properties; antioxidant activity; arginine; calcium; cellulose; coasts; copper; dietary supplements; drying; essential amino acids; functional properties; humans; iron; isoleucine; leucine; linolenic acid; lysine; macroalgae; magnesium; manganese; methionine; minerals; nutrient content; nutritive value; oleic acid; palmitic acid; phenol; proline; sulfates; superoxide anion; threonine; valine; zinc; Iran
- Abstract:
- ... Sirophysalis trinodis and Polycladia myrica, two brown seaweeds present on the southeast coast of Iran, were evaluated for their nutritional and functional properties after drying. Fourier transform-infrared spectroscopy (FTIR) analysis of crude polysaccharides revealed the characteristic absorption bands of phenol, O–H, C–H, C–O–S, C–O, C=O, C–H groups, and β-glycosidic linkages from cellulose, w ...
- DOI:
- 10.1080/10498850.2018.1424281
- https://doi.org/10.1080/10498850.2018.1424281
- Author:
- M. Antonieta Daza Millone; Romina F. Vázquez; Sabina M. Maté; María E. Vela
- Source:
- Colloids and surfaces 2018 v.172 pp. 423-429
- ISSN:
- 0927-7765
- Subject:
- bioactive compounds; biosensors; colloids; dithiothreitol; drugs; erythrocytes; functional properties; gold; humans; lipid bilayers; models; phospholipids; surface plasmon resonance
- Abstract:
- ... Model biomembranes can provide valuable insights into the properties of complex biological membranes. Among several techniques, Surface Plasmon Resonance (SPR) provides a label-free analysis of the interactions of bioactive molecules with biomembranes with an experimental setup that allows mimicking biological environments. Nevertheless, protocols that enable the preparation of stable supported me ...
- DOI:
- 10.1016/j.colsurfb.2018.08.066
- https://doi.org/10.1016/j.colsurfb.2018.08.066
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