Subject: humans / Subject term: humans and functional properties / Text availability: Citation in PubAg

1. 71. Cryopreservation of in vitroshoot-tips of a sweet potato Famaillá 6 clone (Ipomoea batatas (L.) Lam.) by droplet-vitrification technique

Author:: M.V. Rivero; A.M. Clausen; G. Monterubbianesi; A. Digilio
Source:: Cryobiology 2012 v.65 no.3 pp. 362
ISSN:: 0011-2240
Subject:: Ipomoea batatas; aluminum foil; anthocyanins; carotenoids; cryopreservation; disease prevention; ethylene glycol; exposure duration; functional properties; gene banks; genotype; germplasm; germplasm conservation; glycerol; humans; kinetin; labor force; micropropagation; minerals; nitrogen; risk; shoots; space and time; sucrose; sweet potatoes; temperature; vitamins; vitrification
Abstract:: ... Sweet potato varieties constitute a valuable germplasm as a source of carbohydrates, vitamins, fiber and minerals, with excellent functional properties in the prevention of diseases because of the presence of anthocyanins and carotenoids (Martí, 2008; CIP, 2009). The maintenance of germplasm in the field are under risk of losing material, high labor force, time and space consuming (Engelmann and E ...
DOI:: 10.1016/j.cryobiol.2012.07.071
: https://doi.org/10.1016/j.cryobiol.2012.07.071

2. A Peptide Derived from Bovine β-Casein Modulates Functional Properties of Bone Marrow-Derived Macrophages from Germfree and Human Flora-Associated Mice

Author:: Sandré, Catherine; Gleizes, Aude; Forestier, Françoise; Gorges-Kergot, Roseline; Chilmonczyk, Stefan; Léonil, Joëlle; Moreau, Marie-Christiane; Labarre, Colette
Source:: Journal of nutrition 2001 v.131 no.11 pp. 2936-2942
ISSN:: 0022-3166
Subject:: antigens; antimicrobial properties; beta-casein; bioassays; bone marrow; cattle; enzyme-linked immunosorbent assay; flora; flow cytometry; functional properties; humans; immunomodulation; interleukin-12; interleukin-1beta; lipopolysaccharides; macrophage colony-stimulating factor; macrophages; major histocompatibility complex; messenger RNA; mice; phagocytosis; reverse transcriptase polymerase chain reaction; secretion; tumor necrosis factor-alpha
Abstract:: ... The purpose of this study was to evaluate the immunomodulatory activity of a peptide derived from bovine β-casein (β-CN), the β-CN (193-209) peptide, on mouse macrophages that were obtained either from germfree (GF) or from human flora-associated (HF) mice. Macrophages were derived from bone marrow (BMDM) in the presence of recombinant macrophage colony-stimulating factor and exposed to the peptid ...

3. A Pursuit of the Functional Nutritional and Bioactive Properties of Canola Proteins and Peptides

Author:: Ayyappan Appukuttan Aachary; Usha Thiyam
Source:: Critical reviews in food science and nutrition 2012 v.52 no.11 pp. 965-979
ISSN:: 1549-7852
Subject:: animal source protein; bioactive properties; canola; canola meal; digestibility; foods; gelation; humans; peptides; proteins; water holding capacity
Abstract:: ... This review focuses on updated information about canola proteins and peptides, their functional, nutritional, and bioactive properties, safety aspects, and potential application in foods. Attention is paid to gelation, emulsion, thermal, and water holding capacities of crude and pure proteins and peptides isolated from canola meal. Various factors affecting these properties are discussed. This pap ...
DOI:: 10.1080/10408398.2010.516033
PubMed:: 22823345
: https://doi.org/10.1080/10408398.2010.516033

4. A Review on Osmotic Dehydration of Fruits and Vegetables: An Integrated Approach

Author:: V. Ramya; N. K. Jain
Source:: Journal of food process engineering 2017 v.40 no.3 pp. -
ISSN:: 0145-8876
Subject:: agitation; blanching; chemical elements; coatings; color; drying; electric field; energy; energy conservation; engineering; foods; fruits; functional properties; high pressure treatment; humans; mass transfer; mathematical models; mixing; nutrient content; odors; osmosis; osmotic treatment; solutes; temperature; texture; ultrasonic treatment; vegetables
Abstract:: ... Osmotic dehydration is a simultaneous mass transfer process which mainly promotes the flow of water molecules from the food to osmo‐active solution and some migration of solutes from the solution into the food, thus maintaining good organoleptic and functional properties in the finished product. This paper presents mechanism of osmotic dehydration and recent developments regarding the factors affe ...
DOI:: 10.1111/jfpe.12440
: https://doi.org/10.1111/jfpe.12440

5. A Tn antigen binding lectin from Myrsine coriacea displays toxicity in human cancer cell lines

Author:: Andrea Medeiros; Nora Berois; Marcelo Incerti; Sylvie Bay; Laura Franco Fraguas; Eduardo Osinaga
Source:: Natural medicines 2013 v.67 no.2 pp. 247-254
ISSN:: 1340-3443
Subject:: Myrsine; antigens; functional properties; glycosylation; humans; lectins; lymphocytes; molecular weight; toxicity
Abstract:: ... The Tn antigen (GalNAc-O-Ser/Thr) is one of the most specific human cancer-associated structures. In the present study we characterize the biochemical and functional properties of the Myrsine coriacea lectin (McL). We show that McL is an unusual high molecular weight highly glycosylated protein, which displays a strong Tn binding activity. The lectin exhibits in vitro inhibition of proliferation i ...
DOI:: 10.1007/s11418-012-0671-x
PubMed:: 22645079
: https://doi.org/10.1007/s11418-012-0671-x

6. A bacterial 2[4Fe4S] ferredoxin as redox partner of the plastidic-type ferredoxin-NADP+ reductase from Leptospira interrogans

Author:: Arleth S. López Rivero; Ma. Agustina Rossi; Eduardo A. Ceccarelli; Daniela L. Catalano-Dupuy
Source:: Biochimica et biophysica acta 2019 v.1863 no.4 pp. 651-660
ISSN:: 0304-4165
Subject:: Leptospira interrogans; bacteria; biochemical pathways; electrons; ferredoxin-NADP reductase; ferredoxins; functional properties; gene overexpression; genes; humans; mitochondria; models; mutagenesis; plastids
Abstract:: ... Ferredoxins are small iron-sulfur proteins that participate as electron donors in various metabolic pathways. They are recognized substrates of ferredoxin-NADP+ reductases (FNR) in redox metabolisms in mitochondria, plastids, and bacteria. We previously found a plastidic-type FNR in Leptospira interrogans (LepFNR), a parasitic bacterium of animals and humans. Nevertheless, we did not identify plan ...
DOI:: 10.1016/j.bbagen.2019.01.004
: https://doi.org/10.1016/j.bbagen.2019.01.004

7. A biological trait approach to assess the functional composition of subtidal benthic communities in an estuarine ecosystem

Author:: Pieter van der Linden; Joana Patrício; Agnese Marchini; Núria Cid; João Magalhães Neto; João Carlos Marques
Source:: Ecological indicators 2012 v.20 no. pp. 121-133
ISSN:: 1470-160X
Subject:: ecosystems; estuaries; functional diversity; functional properties; humans; invertebrates; salinity; species diversity; Portugal
Abstract:: ... Within transitional/estuarine environments ‘ecosystem functioning’ has been mostly investigated with “traditional” taxonomic analysis, based on the taxonomic composition of benthic invertebrate communities. However, ‘ecosystem functioning’ depends also greatly on the functional characteristics (biological traits) of organisms. It was a priori suggested that the biological traits of the subtidal be ...
DOI:: 10.1016/j.ecolind.2012.02.004
: https://doi.org/10.1016/j.ecolind.2012.02.004

8. A compendium on single‐cell analysis for the curious

Author:: Caroline J. Gallant; Ulf Landegren
Source:: FEBS journal 2019 v.286 no.8 pp. 1442-1444
ISSN:: 1742-464X
Subject:: functional properties; humans; medicine; research programs; therapeutics
Abstract:: ... Single‐cell analysis is impacting biology and medicine by changing the scale and resolution at which we investigate multicellular organisms. A particular, overarching aim of this field is to characterize the programmed development of all different cell types in the human body, as well as their individual spatial, molecular, and functional characteristics. This vast research program is generating a ...
DOI:: 10.1111/febs.14820
: https://doi.org/10.1111/febs.14820

9. A functionally conserved member of the FTZâF1 nuclear receptor family from Schistosoma mansoni

Author:: Ricardo L de MendonÃ§a; Didier Bouton; Benjamin Bertin; Hector Escriva; Christophe NoÃ«l; JeanâMarc Vanacker; Jocelyne Cornette; Vincent Laudet; Raymond J. Pierce
Source:: European journal of biochemistry 2002 v.269 no.22 pp. 5700-5711
ISSN:: 0014-2956
Subject:: DNA-binding domains; Danio rerio; Drosophila; Schistosoma mansoni; adults; cercariae; exons; functional properties; humans; invertebrates; larvae; males; messenger RNA; miracidia; mutants; parasites; phylogeny; protein synthesis; receptors; reporter genes; sexual development; transcription (genetics)
Abstract:: ... The fushi tarazu factor 1 (FTZâF1) nuclear receptor subfamily comprises orphan receptors with crucial roles in development and sexual differentiation in vertebrates and invertebrates. We describe the structure and functional properties of an FTZâF1 from the platyhelminth parasite of humans, Schistosoma mansoni, the first receptor from this family to be characterized in a Lophotrochozoan. It co ...
DOI:: 10.1046/j.1432-1033.2002.03287.x
: https://doi.org/10.1046/j.1432-1033.2002.03287.x

10. A microfluidically perfused three dimensional human liver model

Author:: Knut Rennert; Sandra Steinborn; Marko Gröger; Birgit Ungerböck; Anne-Marie Jank; Josef Ehgartner; Sandor Nietzsche; Julia Dinger; Michael Kiehntopf; Harald Funke; Frank T. Peters; Amelie Lupp; Claudia Gärtner; Torsten Mayr; Michael Bauer; Otmar Huber; Alexander S. Mosig
Source:: Biomaterials 2015 v.71 pp. 119-131
ISSN:: 0142-9612
Subject:: biochemical pathways; coculture; endothelial cells; functional properties; hepatocytes; humans; liver; macrophages; microvilli; models; nutrition; oxygen consumption; secretion; transferrin; transport proteins
Abstract:: ... Within the liver, non-parenchymal cells (NPCs) are critically involved in the regulation of hepatocyte polarization and maintenance of metabolic function. We here report the establishment of a liver organoid that integrates NPCs in a vascular layer composed of endothelial cells and tissue macrophages and a hepatic layer comprising stellate cells co-cultured with hepatocytes. The three-dimensional ...
DOI:: 10.1016/j.biomaterials.2015.08.043
: https://doi.org/10.1016/j.biomaterials.2015.08.043

11. A newly isolated probiotic Enterococcus faecalis strain from vagina microbiota enhances apoptosis of human cancer cells

Author:: Y. Nami; N. Abdullah; B. Haghshenas; D. Radiah; R. Rosli; A. Yari Khosroushahi
Source:: Journal of applied microbiology 2014 v.117 no.2 pp. 498-508
ISSN:: 1364-5072
Subject:: Enterococcus faecalis; adverse effects; anti-infective properties; antibiotic resistance; antineoplastic agents; apoptosis; bacteria; bile resistance; cytotoxicity; functional properties; gastrointestinal system; genes; humans; metabolites; probiotics; proteins; vagina; women
Abstract:: ... AIMS: This study aimed to describe probiotic properties and bio‐therapeutic effects of newly isolated Enterococcus faecalis from the human vaginal tract. METHODS AND RESULTS: The Enterococcus faecalis strain was originally isolated from the vaginal microbiota of Iranian women and was molecularly identified using 16SrDNA gene sequencing. Some biochemical methodologies were preliminarily used to cha ...
DOI:: 10.1111/jam.12531
: https://doi.org/10.1111/jam.12531

12. A novel Kir7.1 splice variant expressed in various mouse tissues shares organisational and functional properties with human Leber amaurosis-causing mutations of this K+ channel

Author:: Erwin Vera; Isabel Cornejo; Johanna Burgos; María Isabel Niemeyer; Francisco V. Sepúlveda; L. Pablo Cid
Source:: Biochemical and biophysical research communications 2019 v.514 no.3 pp. 574-579
ISSN:: 0006-291X
Subject:: choroid plexus; epithelium; functional properties; human cell lines; humans; kidneys; lungs; mice; mutation; permeability; plasma membrane; potassium channels; proteasome endopeptidase complex; retinal diseases; sodium-potassium-exchanging ATPase; vision
Abstract:: ... Kir7.1 is an inwardly rectifying K+ channel present in epithelia where it shares membrane localization with the Na+/K+-pump. In the present communication we report the presence of a novel splice variant of Kir7.1 in mouse tissues including kidney, lung, choroid plexus and retinal pigment epithelium (RPE). The variant named mKir7.1-SV2 lacks most of the C-terminus domain but is predicted to have th ...
DOI:: 10.1016/j.bbrc.2019.04.169
: https://doi.org/10.1016/j.bbrc.2019.04.169

13. A novel bovine serum albumin and sodium alginate hydrogel scaffold doped with hydroxyapatite nanowires for cartilage defects repair

Author:: Huifang Yuan; Xiaoyan Zheng; Wan Liu; Hui Zhang; Jingjing Shao; Jiaxin Yao; Chunyi Mao; Junfeng Hui; Daidi Fan
Source:: Colloids and surfaces 2020 v.192 pp. 111041
ISSN:: 0927-7765
Subject:: bioactive properties; biocompatibility; biocompatible materials; biomimetics; bone marrow; bovine serum albumin; cartilage; functional properties; humans; hydrogels; hydroxyapatite; in vivo studies; mesenchymal stromal cells; nanowires; porosity; sodium alginate; strength (mechanics); tissue engineering
Abstract:: ... Cartilage tissue engineering has become the trend of cartilage defect repair owing to the engineered biomimetic tissue that can mimic the structural, biological and functional characteristics of natural cartilage. Biomaterials with high biocompatibility and regeneration capacity are expected to be used in cartilage tissue engineering. Herein, in this study, a dual-network bovine serum albumin/sodi ...
DOI:: 10.1016/j.colsurfb.2020.111041
: https://doi.org/10.1016/j.colsurfb.2020.111041

14. A novel non-integrative single-cycle chimeric HIV lentivector DNA vaccine

Author:: Maha Moussa; Géraldine Arrode-Brusés; Iliyan Manoylov; Alexander Malogolovkin; Dimitri Mompelat; Honorine Ishimwe; Amel Smaoune; Bilel Ouzrout; Jean Gagnon; Yahia Chebloune
Source:: Vaccine 2015 v.33 no.19 pp. 2273-2282
ISSN:: 0264-410X
Subject:: Caprine arthritis encephalitis virus; DNA; Human immunodeficiency virus 1; animal models; antigens; cell culture; functional properties; gene expression; genes; goats; humans; immune response; immunization; mice; protein synthesis; recombinant vaccines; splenocytes; viral proteins; virion; viruses
Abstract:: ... Novel HIV vaccine vectors and strategies are needed to control HIV/AIDS epidemic in humans and eradicate the infection. DNA vaccines alone failed to induce immune responses robust enough to control HIV-1. Development of lentivirus-based DNA vaccines deficient for integration and with a limited replication capacity is an innovative and promising approach. This type of vaccine mimics the early stage ...
DOI:: 10.1016/j.vaccine.2015.03.021
: https://doi.org/10.1016/j.vaccine.2015.03.021

15. A novel splice variant of supervillin, SV5, promotes carcinoma cell proliferation and cell migration

Author:: Xueran Chen; Haoran Yang; Shangrong Zhang; Zhen Wang; Fang Ye; Chaozhao Liang; Hongzhi Wang; Zhiyou Fang
Source:: Biochemical and biophysical research communications 2017 v.482 pp. 43-49
ISSN:: 0006-291X
Subject:: RNA interference; actin; cell movement; cell proliferation; exons; functional properties; humans; mice; myocardium; myosin; neoplasm cells; neoplasms; smooth muscle; striated muscle
Abstract:: ... Supervillin is an actin-associated protein that regulates actin dynamics by interacting with Myosin II, F-actin, and Cortactin to promote cell contractility and cell motility. Two splicing variants of human Supervillin (SV1 and SV4) have been reported in non-muscle cells; SV1 lacks 3 exons present in the larger isoform SV4. SV2, also called archvillin, is present in striated muscle; SV3, also call ...
DOI:: 10.1016/j.bbrc.2016.11.013
: https://doi.org/10.1016/j.bbrc.2016.11.013

16. A review: Health promoting lactic acid bacteria in traditional Indonesian fermented foods

Author:: Lilis Nuraida
Source:: Food science and human wellness 2015 v.4 no.2 pp. 47-55
ISSN:: 2213-4530
Subject:: Enterococcus; Lactobacillus; Leuconostoc; Pediococcus; buffalo milk; cholesteremic effect; diarrhea; fermented foods; functional properties; health promotion; human health; humans; immune system; in vitro studies; lactic acid bacteria; probiotics; starter cultures
Abstract:: ... Traditional Indonesian fermented foods can be used as potential sources of probiotics as they commonly contain lactic acid bacteria (LAB), including species of Lactobacillus, Pediococcus, Enterococcus, Weisella and Leuconostoc. The occurrence of LAB in Indonesian fermented foods is not only limited to lactic fermented foods but is also present in foods with molds as the main starter culture. This ...
DOI:: 10.1016/j.fshw.2015.06.001
: https://doi.org/10.1016/j.fshw.2015.06.001

17. A simple method of surface functionalisation for immuno-specific immobilisation of proteins

Author:: Kengne-Momo, R. P.; Jeyachandran, Y. L.; Assaf, A.; Esnault, C.; Daniel, P.; Pilard, J. F.; Durand, M. J.; Lagarde, F.; Dongo, E.; Thouand, G.
Source:: Analytical and bioanalytical chemistry 2010 v.398 no.3 pp. 1249-1255
ISSN:: 1618-2642
Subject:: Raman spectroscopy; electrochemistry; functional properties; gold; humans; immunoglobulin G; quartz
Abstract:: ... We present a new and advanced methodology, developed for surface functionalisation of gold and to study immobilisation of an immuno-specific system of proteins. A combination of electrochemical quartz crystal microbalance and Raman spectroscopy techniques allowed a complete understanding of the system starting from surface functionalisation and progressing to the functional structure analysis of i ...
DOI:: 10.1007/s00216-010-4032-x
PubMed:: 20683585
: https://doi.org/10.1007/s00216-010-4032-x

18. Advances in Studies Using Vegetable Wastes to Obtain Pectic Substances: A Review

Author:: Flávia Roberta Buss Marenda; Fernanda Mattioda; Ivo Mottin Demiate; Alicia de Francisco; Carmen Lúcia de Oliveira Petkowicz; Maria Helene Giovanetti Canteri; Renata Dias de Mello Castanho Amboni
Source:: Journal of polymers and the environment 2019 v.27 no.3 pp. 549-560
ISSN:: 1566-2543
Subject:: acetylation; analgesic effect; chemical structure; drug formulations; economic investment; esterification; foods; functional properties; galacturonic acid; humans; in vivo studies; industry; mechanism of action; molecular weight; pectins; raw materials; vegetable residues
Abstract:: ... Vegetable waste represents a serious environmental problem for industries; however, it is also a valuable source of pectic substances. This paper aims to highlight the advances that have been made through studies regarding pectic substances from vegetable wastes, as well as providing an overview of the chemical structure of pectin, extraction and characterisation techniques, and potential applicat ...
DOI:: 10.1007/s10924-018-1355-8
: https://doi.org/10.1007/s10924-018-1355-8

19. Alginate/PVA Beads for Levan Production by Zymomonas mobilis

Author:: Marina F. S. Lorenzetti; Marina R. Moro; Crispin H. García‐Cruz
Source:: Journal of food process engineering 2015 v.38 no.1 pp. 31-36
ISSN:: 0145-8876
Subject:: Zymomonas mobilis; absorption; bacteria; biopolymers; body fat; body weight; calcium; dietary fiber; emulsifiers; encapsulation; fermentation; flavor; food industry; functional properties; gelation; humans; iron; levan; magnesium; microbial contamination; odors; pH; polyvinyl alcohol; processed foods; rats; rheological properties; risk reduction; sucrose; temperature; texture; yogurt; zinc
Abstract:: ... The levan is a biopolymer of great importance to the food industry since it is capable of defining and modifying the structure of one food, acting as stabilizer, thickener, gelling agent and being largely responsible for the texture of processed foods. The levan production by bacterial cell immobilization may potentialize the results of these studies, having advantages such as: high cell concentra ...
DOI:: 10.1111/jfpe.12123
: https://doi.org/10.1111/jfpe.12123

20. Altered response of fibroblasts from human tympanosclerotic membrane to interacting mast cells: Implication for tissue remodeling

Author:: Tadeusz Pawelczyk; Monika Sakowicz-Burkiewicz; Martyna Wesserling; Marzena Grden; Jerzy Kuczkowski
Source:: international journal of biochemistry & cell biology 2014 v.57 pp. 35-44
ISSN:: 1357-2725
Subject:: coculture; collagen; crosslinking; fibroblasts; fibrosis; functional properties; gelatinase B; histology; humans; immunoglobulin E; interleukin-6; mast cells; otitis media; pathogenesis; transforming growth factor beta 1; tumor necrosis factor-alpha
Abstract:: ... Several lines of evidence suggest that a tympanosclerotic (TMS) lesion often develops secondary to acute and chronic otitis media. Histological findings indicate that fibroblasts and inflammatory cells, including mast cells, play a key role in the tympanosclerotic plaque formation. However, details on the functional characteristics of tympanosclerotic fibroblasts (FsᵀᴹS) are scanty. Therefore the ...
DOI:: 10.1016/j.biocel.2014.10.002
: https://doi.org/10.1016/j.biocel.2014.10.002

21. An overview of plant-autochthonous microorganisms and fermented vegetable foods

Author:: Sebastian Torres; Hernán Verón; Luciana Contreras; Maria I. Isla
Source:: Food science and human wellness 2020 v.9 no.2 pp. 112-123
ISSN:: 2213-4530
Subject:: beverages; fermentation; fermented vegetables; fruits; functional properties; human health; humans; microorganisms; plant-based foods; shelf life; starter cultures; vegetables
Abstract:: ... Fermented plant-based foods and beverages constitute foods of high nutritional and functional value with appreciated health beneficial effects. They represent a natural and sustainable alternative to counteract the large wastage of vegetables and fruits due to their short shelf life. Usually, the use of controlled fermentation process using autochthonous microorganisms adapted to their vegetable m ...
DOI:: 10.1016/j.fshw.2020.02.006
: https://doi.org/10.1016/j.fshw.2020.02.006

22. An overview of separation methods in starch analysis: The importance of size exclusion chromatography and field flow fractionation

Author:: Heinrich RÃ¼bsam; Martin Krottenthaler; Martina Gastl; Thomas Becker
Source:: StaÌrke = 2012 v.64 no.9 pp. 683-695
ISSN:: 0038-9056
Subject:: fractionation; energy; humans; industry; starch; ultracentrifugation; gel chromatography; processed foods; biofuels; functional properties
Abstract:: ... Starch is the most important source of human food energy and also an important polymer for biofuels, processed food, and pharmaceutical industries. Precise determination of structural and functional properties of starch has been an outstanding factor for the improvement of dissolution and degradation processes, which are important procedures for commercial applications. Distinct separation techniq ...
DOI:: 10.1002/star.201100188
: https://doi.org/10.1002/star.201100188

23. Analysis of Calcium Transients and Uniaxial Contraction Force in Single Human Embryonic Stem Cell-Derived Cardiomyocytes on Microstructured Elastic Substrate with Spatially Controlled Surface Chemistries

Author:: Grespan Eleonora; Martewicz Sebastian; Serena Elena; Le Houerou Vincent; Rühe Jürgen; Elvassore Nicola
Source:: Langmuir 2016 v.32 no.46 pp. 12190-12201
ISSN:: 1520-5827
Subject:: calcium; cardiomyocytes; cell growth; contractile proteins; drugs; evolution; finite element analysis; fluorescence microscopy; functional properties; humans; models; photochemistry; screening
Abstract:: ... The mechanical activity of cardiomyocytes is the result of a process called excitation–contraction coupling (ECC). A membrane depolarization wave induces a transient cytosolic calcium concentration increase that triggers activation of calcium-sensitive contractile proteins, leading to cell contraction and force generation. An experimental setup capable of acquiring simultaneously all ECC features ...
DOI:: 10.1021/acs.langmuir.6b03138
: https://doi.org/10.1021/acs.langmuir.6b03138

24. Analysis of Single-Nucleotide Polymorphisms in Human Voltage-Gated Ion Channels

Author:: Katerina C. Nastou; Michail A. Batskinis; Zoi I. Litou; Stavros J. Hamodrakas; Vassiliki A. Iconomidou
Source:: Journal of proteome research 2019 v.18 no.5 pp. 2310-2320
ISSN:: 1535-3907
Subject:: amino acid sequences; arginine; cysteine; databases; electric potential difference; functional properties; genetic variation; glutamine; histidine; humans; ion channels; membrane potential; phenotype; proteome; single nucleotide polymorphism; statistical analysis; topology; transmembrane proteins
Abstract:: ... Voltage-gated ion channels (VGICs) are one of the largest groups of transmembrane proteins. Due to their major role in the generation and propagation of electrical signals, VGICs are considered important from a medical viewpoint, and their dysfunction is often associated with Channelopathies. We identified disease-associated mutations and polymorphisms in these proteins through mapping missense si ...
DOI:: 10.1021/acs.jproteome.9b00121
: https://doi.org/10.1021/acs.jproteome.9b00121

25. Analysis of adenovirus-induced immunity to infection with Listeria monocytogenes: Fading protection coincides with declining CD8 T cell numbers and phenotypic changes

Author:: Marie Louise Jahn; Maria Abildgaard Steffensen; Jan Pravsgaard Christensen; Allan Randrup Thomsen
Source:: Vaccine 2018 v.36 no.20 pp. 2825-2832
ISSN:: 0264-410X
Subject:: CD8-positive T-lymphocytes; Listeria monocytogenes; antigens; functional properties; glycoproteins; humans; immunity; longevity; phenotype; phenotypic plasticity; serotypes; vaccination; vaccines
Abstract:: ... Defining correlates of T cell mediated protection is important in order to accelerate the development of efficient T cell based vaccines conferring long-term immunity.Extensive studies have provided important insight regarding the characteristics and functional properties of the effector and memory CD8 T cells induced by viral vector based vaccines. However, long-term protection has been difficult ...
DOI:: 10.1016/j.vaccine.2018.03.080
: https://doi.org/10.1016/j.vaccine.2018.03.080

26. Analysis of functional properties of biologically active substances using eukaryotic cell models (review)

Author:: K. V. Lisitskaya; I. V. Nikolaev; A. A. Torkova; V. O. Popov; O. V. Koroleva
Source:: Applied biochemistry and microbiology 2012 v.48 no.6 pp. 525-540
ISSN:: 0003-6838
Subject:: bioactive properties; cell culture; chemoprevention; eukaryotic cells; functional properties; humans; models; prebiotics
Abstract:: ... This work presents an analysis of current data on the investigation into the functional properties of biologically active substances in model systems based on cultivated human cells. The knowledge regarding the practical application of cell cultures for the analysis of functional properties of bioactive substances is summarized, including antioxidant, immunomodulating, pro- and prebiotics, and che ...
DOI:: 10.1134/S0003683812060087
: https://doi.org/10.1134/S0003683812060087

27. Antagonistic effect of chitinolytic Pseudomonas and Bacillus on growth of fungal hyphae and spores of aflatoxigenic Aspergillus flavus

Author:: Pervin Basaran Akocak; John J. Churey; Randy W. Worobo
Source:: Food bioscience 2015 v.10 pp. 48-58
ISSN:: 2212-4292
Subject:: Aspergillus flavus; Bacillus cereus; Bacillus thuringiensis; N-acetylglucosamine; Pseudomonas fluorescens; aflatoxins; biological control; chitinase; functional properties; fungal spores; fungi; hazelnuts; humans; hyphae; mycelium; polymers; postharvest losses; scanning electron microscopy; spore germination; toxicity
Abstract:: ... Use of biological control methods has become a promising strategy to counteract deleterious fungal contaminations and substantial post harvest losses. One of the major biological control methods is found in the use of fungal cell wall-degrading enzymes such as chitinases, which hydrolyze the homopolymer of β-1,4-1inked N-acetylglucosamine residues exposed on the fungal cell surface. In this study, ...
DOI:: 10.1016/j.fbio.2015.01.005
: https://doi.org/10.1016/j.fbio.2015.01.005

28. Antioxidant and anticancer effects of functional peptides from ovotransferrin hydrolysates

Author:: Jae Hoon Lee; Sun Hee Moon; Hyun Suk Kim; Eunju Park; Dong Uk Ahn; Hyun‐Dong Paik
Source:: Journal of the science of food and agriculture 2017 v.97 no.14 pp. 4857-4864
ISSN:: 0022-5142
Subject:: 2,2-diphenyl-1-picrylhydrazyl; antineoplastic activity; antioxidant activity; antiviral properties; cytotoxicity; egg albumen; enzymatic hydrolysis; enzymes; food industry; free radical scavengers; functional properties; humans; hydrolysates; ingredients; inhibitory concentration 50; neoplasms; nitric oxide; peptides
Abstract:: ... BACKGROUND: Egg white is a good source for making functional peptides that can be used in the food industry. Ovotransferrin (OTF) is one of the major egg white proteins, with many functional properties, including antioxidant, antimicrobial and antiviral activities. However, enzymatic hydrolysis of ovotransferrin is known to further improve the functional activities of OTF. The aim of this study wa ...
DOI:: 10.1002/jsfa.8356
: https://doi.org/10.1002/jsfa.8356

29. Antioxidant, angiotensin-converting enzyme inhibitory activity and other functional properties of egg white proteins and their derived peptides – A review

Author:: E.D.N.S. Abeyrathne; X. Huang; D.U. Ahn
Source:: Poultry science 2018 v.97 no.4 pp. 1462-1468
ISSN:: 0032-5791
Subject:: antimicrobial properties; antioxidants; avidin; chemical treatment; egg albumen; enzymatic hydrolysis; enzyme inhibition; food processing; functional properties; heat treatment; humans; lysozyme; molecular weight; ovalbumin; ovomucin; pH; peptides; peptidyl-dipeptidase A
Abstract:: ... Egg white contains many functionally important proteins: ovalbumin (54%), ovotransferrin (12%), ovomucoid (11%), ovoglobulin (G2 and G3, 8%), ovomucin (3.5%), and lysozyme (3.5%) are major proteins, while ovoinhibitors, ovomacroglobulin, ovoglycoprotein, ovoflavoprotein, thiamine-binding proteins, and avidin are minor proteins present in egg white. These proteins, as well as the peptides derived f ...
DOI:: 10.3382/ps/pex399
: https://doi.org/10.3382/ps/pex399

30. Application and bioactive properties of proteins and peptides derived from hen eggs: opportunities and challenges

Author:: Zhipeng Yu; Yongguang Yin; Wenzhu Zhao; Feng Chen; Jingbo Liu
Source:: Journal of the science of food and agriculture 2014 v.94 no.14 pp. 2839-2845
ISSN:: 0022-5142
Subject:: absorption; antioxidants; bioactive properties; cardiovascular system; dietary protein; eggs; food industry; functional properties; gastrointestinal system; hens; humans; immune system; nervous system; peptides; proteins
Abstract:: ... Several proteins and peptides that are released in vitro and/or in vivo from hen eggs are biologically active and have a variety of functional properties in humans beyond normal nutrition, for which extensive studies have been performed. This review focuses on their biological activities, including antihypertensive, antioxidant, antimicrobial, antiadhesive, immunomodulatory and antithrombotic acti ...
DOI:: 10.1002/jsfa.6670
PubMed:: 24652758
: https://doi.org/10.1002/jsfa.6670

31. Application of diagnosticum based on functionalized carbon nanoparticles for monitoring of immunoglobulins affinity purification

Author:: P. V. Khramtsov; M. S. Bochkova; M. B. Rayev
Source:: Applied biochemistry and microbiology 2014 v.50 no.6 pp. 683-688
ISSN:: 0003-6838
Subject:: G-proteins; Streptococcus; blood serum; carbon; functional properties; humans; immunoglobulin G; monitoring; nanoparticles; polyclonal antibodies; rabbits; shelf life
Abstract:: ... A diagnostic reagent based on carbon nanoparticles covalently functionalized with streptococcus G protein was applied to construct a system for monitoring and optimization of the technology of affinity purification of rabbit polyclonal antibodies to alpha-fetoprotein. The developed system allows a short-time (45 min) semiquantitative assessment of the immunoglobulins (IgG) of most higher animals a ...
DOI:: 10.1134/S0003683814060064
: https://doi.org/10.1134/S0003683814060064

32. Artificial structures alter kelp functioning across an urbanised estuary

Author:: M. Mayer-Pinto; K.A. Dafforn; A.B. Bugnot; T.M. Glasby; E.L. Johnston
Source:: Marine environmental research 2018 v.139 pp. 136-143
ISSN:: 0141-1136
Subject:: Ecklonia radiata; anthropogenic activities; biomechanics; detritus; ecological footprint; environmental impact; estuaries; functional properties; habitats; humans; infrastructure; macroalgae; marine environment; photosynthesis; prediction; reefs; secondary productivity; sublethal effects; urbanization
Abstract:: ... Assessments of human impacts on natural habitats often focus on the abundance of component species, yet physiological and/or sub-lethal effects of stressors on functional attributes may be equally important to consider. Here we evaluated how artificial structures, an integral part of urbanisation in the marine environment, affects key functional properties of the habitat-forming kelp Ecklonia radi ...
DOI:: 10.1016/j.marenvres.2018.05.004
: https://doi.org/10.1016/j.marenvres.2018.05.004

33. Association of human tumor necrosis factor‐related apoptosis inducing ligand with membrane upon acidification

Author:: Gyu Hyun Nam; Kwan Yong Choi
Source:: European journal of biochemistry 2002 v.269 no.21 pp. 5280-5287
ISSN:: 0014-2956
Subject:: acidification; apoptosis; crystal structure; denaturation; fluorescence; functional properties; humans; hydrophobicity; lymphotoxin; necrosis; pH; phase transition; proteins; solvents; tryptophan; tumor necrosis factor-alpha; wavelengths
Abstract:: ... Tumor necrosis factor (TNF)‐related apoptosis inducing ligand (TRAIL) has been known to induce tumor‐specific apoptosis and to share the structural and functional characteristics with the proteins of TNF family. Recently, the crystal structure of human TRAIL showed that TRAIL is a homotrimeric protein whose subunits contain mainly β‐sheets. We characterized the structural changes of recombinant hu ...
DOI:: 10.1046/j.1432-1033.2002.03242.x
: https://doi.org/10.1046/j.1432-1033.2002.03242.x

34. Barley yellow dwarf viruses (BYDVs) preserved in herbarium specimens illuminate historical disease ecology of invasive and native grasses

Author:: MALMSTROM, CAROLYN M.; SHU, RUIJIE; LINTON, ERIC W.; NEWTON, LINSEY A.; COOK, MERIDITH A.
Source:: Journal of ecology 2007 v.95 no.6 pp. 1153-1166
ISSN:: 0022-0477
Subject:: Luteoviridae; RNA; barley; ecological invasion; ecosystems; functional properties; grasses; grasslands; herbaria; home range; horticulture; humans; indigenous species; invasive species; nucleotide sequences; pathogens; phylogeny; Australia; California
Abstract:: ... 1. In plant invasion ecology, viruses and other pathogens are often considered in terms of the enemy release hypothesis, which predicts that plants become invasive in new ranges if they escape pathogens from their home range. However, pathogens may sometimes facilitate host spread rather than hinder it. 2. Previously, we hypothesized that apparent competition mediated by barley and cereal yellow d ...
DOI:: 10.1111/j.1365-2745.2007.01307.x
: https://doi.org/10.1111/j.1365-2745.2007.01307.x

35. Beyond spectral tuning: human cone visual pigments adopt different transient conformations for chromophore regeneration

Author:: Sundaramoorthy Srinivasan; Arnau Cordomí; Eva Ramon; Pere Garriga
Source:: Cellular and molecular life sciences 2016 v.73 no.6 pp. 1253-1263
ISSN:: 1420-682X
Subject:: color vision; cones (retina); dark adaptation; functional properties; humans; molecular models; opsin; phototransduction; receptors; schiff bases; site-directed mutagenesis; spectroscopy
Abstract:: ... Human red and green visual pigments are seven transmembrane receptors of cone photoreceptor cells of the retina that mediate color vision. These pigments share a very high degree of homology and have been assumed to feature analogous structural and functional properties. We report on a different regeneration mechanism among red and green cone opsins with retinal analogs using UV–Vis/fluorescence s ...
DOI:: 10.1007/s00018-015-2043-7
: https://doi.org/10.1007/s00018-015-2043-7

36. Bioactive properties and functional constituents of Hypericum androsaemum L.: A focus on the phenolic profile

Author:: Inés Jabeur; Flávia Tobaldini; Natália Martins; Lillian Barros; Ivone Martins; Ricardo C. Calhelha; Mariana Henriques; Sónia Silva; Lotfi Achour; Celestino Santos-Buelga; Isabel C.F.R. Ferreira
Source:: Food research international 2016 v.89 pp. 422-431
ISSN:: 0963-9969
Subject:: Hypericum androsaemum; active ingredients; anti-inflammatory activity; biofilm; chlorogenic acid; dose response; free radical scavengers; functional properties; growth retardation; hepatocytes; humans; lipid peroxidation; neoplasm cells; nitric oxide; phenolic compounds; swine; toxicity
Abstract:: ... Hypericum androsaemum L. ethanol:water extract acted as a lipid peroxidation inhibitor and free radical scavenger. A marked inhibition of the growth of breast, lung, cervical and hepatocellular human carcinoma cell lines was also observed, whereas no toxicity was shown against non-tumor porcine liver cells (>400μg/mL). The extract was also effective in inhibiting nitric oxide production, as an ind ...
DOI:: 10.1016/j.foodres.2016.08.040
: https://doi.org/10.1016/j.foodres.2016.08.040

37. Bioactivity of soy-based fermented foods: A review

Author:: Zhen-Hui Cao; Julia M. Green-Johnson; Nicole D. Buckley; Qiu-Ye Lin
Source:: Biotechnology advances 2019 v.37 no.1 pp. 223-238
ISSN:: 0734-9750
Subject:: animal models; bioactive compounds; consumer demand; diet; fermentation; flavor; functional properties; guidelines; humans; lifestyle; medical history; metabolites; microbial communities; microbiome; microorganisms; natto; nutritive value; soy sauce; soymilk; tempeh; toxicity; Asia
Abstract:: ... For centuries, fermented soy foods have been dietary staples in Asia and, now, in response to consumer demand, they are available throughout the world. Fermentation bestows unique flavors, boosts nutritional values and increases or adds new functional properties. In this review, we describe the functional properties and underlying action mechanisms of soy-based fermented foods such as Natto, ferme ...
DOI:: 10.1016/j.biotechadv.2018.12.001
: https://doi.org/10.1016/j.biotechadv.2018.12.001

38. Biomechanical and functional properties of trophoblast cells exposed to Group B Streptococcus in vitro and the beneficial effects of uvaol treatment

Author:: R.M. Botelho; L.P.G. Tenorio; A.L.M. Silva; E.L.L. Tanabe; K.S.N. Pires; C.M. Gonçalves; J.C. Santos; A.L.X. Marques; M.J. Allard; J.D. Bergeron; G. Sebire; E.C.O. Silva; S.T. Souza; E.J.S. Fonseca; A.U. Borbely; K.S.C. Borbely
Source:: Biochimica et biophysica acta 2019 v.1863 no.9 pp. 1417-1428
ISSN:: 0304-4165
Subject:: Streptococcus agalactiae; atomic force microscopy; bacteria; biomechanics; cell death; cell viability; cytoskeleton; death; diet; fluorescent antibody technique; functional properties; humans; inflammation; interferon-gamma; interleukin-1beta; interleukin-2; interleukin-4; nitrites; olive oil; pregnancy; pregnant women; secretion; triterpenoids; trophoblast
Abstract:: ... Group B streptococcus (GBS) is the main bacteria that infects pregnant women and can cause abortion and chorioamnionitis. The impact of GBS effects on human trophoblast cells remains largely elusive, and actions toward anti-inflammatory strategies in pregnancy are needed. A potent anti-inflammatory molecule, uvaol is a triterpene from olive oil and its functions in trophoblasts are unknown. We aim ...
DOI:: 10.1016/j.bbagen.2019.06.012
: https://doi.org/10.1016/j.bbagen.2019.06.012

39. Biomimetic LBL structured nanofibrous matrices assembled by chitosan/collagen for promoting wound healing

Author:: Rong Huang; Wangzhou Li; Xiaoxing Lv; Zhanjun Lei; Yongqian Bian; Hongbing Deng; Hongjun Wang; Jinqing Li; Xueyong Li
Source:: Biomaterials 2015 v.53 pp. 58-75
ISSN:: 0142-9612
Subject:: CD29 antigen; Western blotting; acetates; biocompatibility; biomimetics; cell movement; chitosan; collagen; fibroblasts; functional properties; humans; immunohistochemistry; nanofibers; non-specific protein-tyrosine kinase; phosphorylation; scanning electron microscopy; secretion; signal transduction; tubulin
Abstract:: ... This paper reports the fabrication of biomimetic nanofibrous matrices via co-electrospinning of polycaprolactone (PCL)/cellulose acetate (CA) and layer-by-layer self-assembly (LBL) of positively charged chitosan (CS) and negatively charged Type Ⅰ collagen on the nanofibrous matrix. FE-SEM images indicate that the average fiber diameter increased from 392 to 541 nm when the coating bilayers varied ...
DOI:: 10.1016/j.biomaterials.2015.02.076
: https://doi.org/10.1016/j.biomaterials.2015.02.076

40. Biomimetic cardiovascular platforms for in vitro disease modeling and therapeutic validation

Author:: Roberto Portillo-Lara; Andrew R. Spencer; Brian W. Walker; Ehsan Shirzaei Sani; Nasim Annabi
Source:: Biomaterials 2019 v.198 pp. 78-94
ISSN:: 0142-9612
Subject:: biocompatible materials; biofabrication; biomimetics; cardiovascular diseases; cell engineering; diagnostic techniques; drugs; functional properties; genetic engineering; health services; humans; industry; microfluidic technology; mortality; myocardium; organ-on-a-chip; patients; screening; stem cells; therapeutics; tissue engineering
Abstract:: ... Bioengineered tissues have become increasingly more sophisticated owing to recent advancements in the fields of biomaterials, microfabrication, microfluidics, genetic engineering, and stem cell and developmental biology. In the coming years, the ability to engineer artificial constructs that accurately mimic the compositional, architectural, and functional properties of human tissues, will profoun ...
DOI:: 10.1016/j.biomaterials.2018.08.010
: https://doi.org/10.1016/j.biomaterials.2018.08.010

41. Biopolymer-based coacervates: Structures, functionality and applications in food products

Author:: Thomas Moschakis; Costas G. Biliaderis
Source:: Current opinion in colloid & interface science 2017 v.28 pp. 96-109
ISSN:: 1359-0294
Subject:: bioactive compounds; biopolymers; digestion; foods; functional properties; gastrointestinal system; humans; ingredients; manufacturing; polysaccharides; proteins
Abstract:: ... Complex coacervates are self-assembly structures with many potential functional properties. Coacervates are mainly fabricated from proteins and polysaccharides and therefore they can be designed to function over a wide range of conditions in food products by withstanding adverse environmental stresses during manufacturing and storage and even upon passage through the human digestive track. They ca ...
DOI:: 10.1016/j.cocis.2017.03.006
: https://doi.org/10.1016/j.cocis.2017.03.006

42. Bioprocessing of human mesenchymal stem/stromal cells for therapeutic use: Current technologies and challenges

Author:: Aletta C. Schnitzler; Anjali Verma; Daniel E. Kehoe; Donghui Jing; Julie R. Murrell; Kara A. Der; Manjula Aysola; Peter J. Rapiejko; Sandhya Punreddy; Martha S. Rook
Source:: Biochemical engineering journal 2016 v.108 pp. 3-13
ISSN:: 1369-703X
Subject:: bioprocessing; cell culture; functional properties; humans; manufacturing; medicine; phenotype; stem cells; stromal cells; therapeutics; viability
Abstract:: ... The long-term outlook for regenerative medicine predicts an increased need for scalable cell expansion technologies that utilize non-animal derived materials and are compatible with the limited number of downstream processing steps required for cell-based therapies. As more stem cell therapeutics progress through clinical testing, current in vitro culture methods using planar vessels are proving c ...
DOI:: 10.1016/j.bej.2015.08.014
: https://doi.org/10.1016/j.bej.2015.08.014

43. Biosynthesis of dextran by Weissella confusa and its In vitro functional characteristics

Author:: Irina Rosca; Anca Roxana Petrovici; Dragos Peptanariu; Alina Nicolescu; Gianina Dodi; Mihaela Avadanei; Iuliu Cristian Ivanov; Andra Cristina Bostanaru; Mihai Mares; Diana Ciolacu
Source:: International journal of biological macromolecules 2018 v.107 pp. 1765-1772
ISSN:: 0141-8130
Subject:: Candida albicans; Fourier transform infrared spectroscopy; UHT milk; Weissella confusa; antibacterial properties; biofilm; biosynthesis; culture media; cytotoxicity; dextran; drugs; exopolysaccharides; fermentation; fibroblasts; freeze drying; functional properties; humans; hydrophilicity; lactic acid bacteria; nuclear magnetic resonance spectroscopy; nucleotide sequences; pharmaceutical industry; polymers; ribosomal DNA; sucrose; thermal analysis
Abstract:: ... The aim of this study was to monitor the influence of the fermentation conditions on the exopolysaccharides (EPS) biosynthesis. For this, different culture media compositions were tested on an isolated lactic acid bacteria (LAB) strain, identified by 16S rDNA sequence as being Weissella confusa. It was proved that this bacterial strain culture in MRS medium supplemented with 80g/L sucrose and diss ...
DOI:: 10.1016/j.ijbiomac.2017.10.048
: https://doi.org/10.1016/j.ijbiomac.2017.10.048

44. Black Pepper and Health Claims: A Comprehensive Treatise

Author:: Masood Sadiq Butt; Imran Pasha; Muhammad Tauseef Sultan; Muhammad Atif Randhawa; Farhan Saeed; Waqas Ahmed
Source:: Critical reviews in food science and nutrition 2013 v.53 no.9 pp. 875-886
ISSN:: 1549-7852
Subject:: Piper nigrum; absorption; active ingredients; alkaloids; antidepressants; antioxidants; bioactive properties; black pepper; brain; cell culture; chemoprevention; cognition; cohort studies; functional foods; gastrointestinal system; health claims; healthy diet; humans; models; nutrients; oils; oleoresins; plant biochemistry; randomized clinical trials; trade
Abstract:: ... For millennia, spices have been an integral part of human diets and commerce. Recently, the widespread recognition of diet-health linkages bolsters their dietary importance. The bioactive components present in them are of considerable significance owing to their therapeutic potential against various ailments. They provide physiological benefits or prevent chronic ailment in addition to the fundame ...
DOI:: 10.1080/10408398.2011.571799
PubMed:: 23768180
: https://doi.org/10.1080/10408398.2011.571799

45. C-termini are essential and distinct for nucleic acid binding of human NABP1 and NABP2

Author:: Venkatasubramanian Vidhyasagar; Yujiong He; Manhong Guo; Hao Ding; Tanu Talwar; Vi Nguyen; Jessica Nwosu; George Katselis; Yuliang Wu
Source:: Biochimica et biophysica acta 2016 v.1860 no.2 pp. 371-383
ISSN:: 0304-4165
Subject:: DNA-binding proteins; RNA; centrifugation; circular dichroism spectroscopy; functional properties; gel chromatography; humans; mass spectrometry; oligomerization; single-stranded DNA; sucrose
Abstract:: ... Human Nucleic Acid Binding Protein 1 and 2 (hNABP1 and 2; also known as hSSB2 and 1, respectively) are two newly identified single-stranded (ss) DNA binding proteins (SSB). Both NABP1 and NABP2 have a conserved oligonucleotide/oligosaccharide-binding (OB)-fold domain and a divergent carboxy-terminal domain, the functional importance of which is unknown.Recombinant hNABP1/2 proteins were purified u ...
DOI:: 10.1016/j.bbagen.2015.11.003
: https://doi.org/10.1016/j.bbagen.2015.11.003

46. CD11c⁺ Cells are Significantly Decreased in the Duodenum, Ileum and Colon of Dogs with Inflammatory Bowel Disease

Author:: A. Kathrani; S. Schmitz; S.L. Priestnall; K.C. Smith; D. Werling; O.A. Garden; K. Allenspach
Source:: Journal of comparative pathology 2011 v.145 no.4 pp. 359-366
ISSN:: 0021-9975
Subject:: Beagle; biopsy; colon; dendritic cells; dogs; duodenum; fluorescence microscopy; functional properties; guidelines; humans; ileum; inflammation; inflammatory bowel disease; mice; monoclonal antibodies
Abstract:: ... CD11c serves as a marker for human and murine dendritic cells (DCs) and cells expressing this marker have been shown to have similar morphological and functional characteristics in the canine immune system. The aim of this study was to quantify CD11c⁺ cells in the duodenum, ileum and colon of healthy dogs and dogs with inflammatory bowel disease (IBD). Endoscopic biopsies from the duodenum (n=12 c ...
DOI:: 10.1016/j.jcpa.2011.03.010
PubMed:: 21592490
: https://doi.org/10.1016/j.jcpa.2011.03.010

47. CLERC and centrosomal leucine-rich repeat proteins

Author:: Yoshinori Muto; Yukio Okano
Source:: Open life sciences 2010 v.5 no.1 pp. 1-10
ISSN:: 2391-5412
Subject:: Chlamydomonas; centrosomes; databases; functional properties; humans; mitosis; proteins; proteome
Abstract:: ... The centrosome functions as the microtubule-organizing center and plays a vital role in organizing spindle poles during mitosis. Recently, we identified a centrosomal protein called CLERC (Centrosomal leucine-rich repeat and coiled-coil containing protein) which is a human ortholog of Chlamydomonas Vfl1 protein. The bibliography as well as database searches provided evidence that the human proteom ...
DOI:: 10.2478/s11535-009-0061-x
: https://doi.org/10.2478/s11535-009-0061-x

48. Calmodulin mutations causing catecholaminergic polymorphic ventricular tachycardia confer opposing functional and biophysical molecular changes

Author:: Mads T. Søndergaard; Anders B. Sorensen; Louise L. Skov; Kasper Kjaer‐Sorensen; Mikael C. Bauer; Mette Nyegaard; Sara Linse; Claus Oxvig; Michael T. Overgaard
Source:: FEBS journal 2015 v.282 no.4 pp. 803-816
ISSN:: 1742-464X
Subject:: Danio rerio; abnormal development; animal models; calmodulin; cardiomyocytes; death; eukaryotic cells; exercise; functional properties; heart rate; humans; messenger RNA; mutation; phenotype; syncope; tachycardia
Abstract:: ... Calmodulin (CaM) is the central mediator of intracellular Ca²⁺signalling in cardiomyocytes, where it conveys the intricate Ca²⁺transients to the proteins controlling cardiac contraction. We recently linked two separate mutations in CaM (N53I and N97S) to dominantly inherited catecholaminergic polymorphic ventricular tachycardia (CPVT), an arrhythmic disorder in which exercise or acute emotion can ...
DOI:: 10.1111/febs.13184
: https://doi.org/10.1111/febs.13184

49. Camu-camu seed (Myrciaria dubia) – From side stream to an antioxidant, antihyperglycemic, antiproliferative, antimicrobial, antihemolytic, anti-inflammatory, and antihypertensive ingredient

Author:: Marina Fidelis; Mariana Araújo Vieira do Carmo; Thiago Mendanha da Cruz; Luciana Azevedo; Takao Myoda; Marianna Miranda Furtado; Mariza Boscacci Marques; Anderson S. Sant'Ana; Maria Inês Genovese; Won Young Oh; Mingchun Wen; Fereidoon Shahidi; Liang Zhang; Marcelo Franchin; Severino Matias de Alencar; Pedro Luiz Rosalen; Daniel Granato
Source:: Food chemistry 2020 v.310 pp. 125909
ISSN:: 0308-8146
Subject:: Myrciaria dubia; alpha-amylase; alpha-glucosidase; antihypertensive effect; antimicrobial properties; antioxidant activity; antioxidants; bioactive compounds; bioassays; cell culture; copper; cytotoxicity; enzyme inhibition; erythrocytes; functional properties; glycemic effect; hemolysis; humans; ingredients; low density lipoprotein; macrophages; neoplasm cells; neoplasms; oxidation; phenolic compounds; seeds; solvents; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:: ... Camu-camu (Myrciaria dubia) seeds are discarded without recovering the bioactive compounds. The main aim of the present work was to optimise the solvent mixture to extract higher total phenolic content and antioxidant capacity of camu-camu seeds. The optimised solvent system increased the extraction of phenolic compounds, in which vescalagin and castalagin were the main compounds. The optimised ex ...
DOI:: 10.1016/j.foodchem.2019.125909
: https://doi.org/10.1016/j.foodchem.2019.125909

50. Cardiac tissue engineering using tissue printing technology and human cardiac progenitor cells

Author:: Roberto Gaetani; Peter A. Doevendans; Corina H.G. Metz; Jacqueline Alblas; Elisa Messina; Alessandro Giacomello; Joost P.G. Sluijter
Source:: Biomaterials 2012 v.33 no.6 pp. 1782-1790
ISSN:: 0142-9612
Subject:: biocompatible materials; bioprinting; cardiomyocytes; cell viability; functional properties; gene expression; humans; stem cells; therapeutics; tissue engineering; transcription factors
Abstract:: ... Tissue engineering is emerging as a potential therapeutic approach to overcome limitations of cell therapy, like cell retention and survival, as well as to mechanically support the ventricular wall and thereby prevent dilation. Tissue printing technology (TP) offers the possibility to deliver, in a defined and organized manner, scaffolding materials and living cells. The aim of our study was to ev ...
DOI:: 10.1016/j.biomaterials.2011.11.003
: https://doi.org/10.1016/j.biomaterials.2011.11.003

51. Cardioprotective properties of grape seed proanthocyanidins: An update

Author:: M. Antónia Nunes; Filipa Pimentel; Anabela S.G. Costa; Rita C. Alves; Maria Beatriz P.P. Oliveira
Source:: Trends in food science & technology 2016 v.57 pp. 31-39
ISSN:: 0924-2244
Subject:: Vitis vinifera; agricultural industry; bark; blood lipids; blood pressure; byproducts; cardioprotective effect; cardiovascular diseases; endothelium; foods; fruits; functional properties; grape seeds; grapes; human health; humans; ingredients; nutritive value; nuts; proanthocyanidins; risk factors; seeds; synergism; value added
Abstract:: ... The nutritional properties of grapes (Vitis vinifera L.) and derived-grape products are known for a long time. To produce those food products, the agro-industry generates great amounts of by-products. The re-use of these undervalued materials is challenging because it represents an attractive opportunity to convert them into value-added sources of natural ingredients with potential human health be ...
DOI:: 10.1016/j.tifs.2016.08.017
: https://doi.org/10.1016/j.tifs.2016.08.017

52. Characteristics and Nutritional and Cardiovascular-Health Properties of Seaweeds

Author:: Bocanegra, Aránzazu; Bastida, Sara; Benedi, Juana; Rodenas, Sofia; Sánchez-Muniz, Francisco J.
Source:: Journal of medicinal food 2009 v.12 no.2 pp. 236-258
ISSN:: 1096-620X
Subject:: nutrient content; algae; vitamins; blood pressure; health foods; energy content; edible seaweed; mineral content; dietary fiber; humans; phytochemicals; body weight; lipid metabolism; antioxidant activity; weight gain; nutrient availability; nutritive value; functional properties; polyunsaturated fatty acids; dietary minerals
DOI:: 10.1089/jmf.2008.0151
PubMed:: 19459725
: https://doi.org/10.1089/jmf.2008.0151

53. Characteristics of One Health surveillance systems: A systematic literature review

Author:: Marion Bordier; Theethawat Uea-Anuwong; Aurélie Binot; Pascal Hendrikx; Flavie L. Goutard
Source:: Preventive veterinary medicine 2020 v.181 pp. 104560
ISSN:: 0167-5877
Subject:: One Health initiative; cost effectiveness; databases; environmental health; functional properties; governance; guidelines; health hazards; humans; monitoring; screening; stakeholders; uncertainty
Abstract:: ... The concept of One Health (OH) promotes the decompartmentalisation of human, animal, and ecosystem health for the more efficient and sustainable governance of complex health issues. This means that traditional boundaries between disciplines and sectors must be transgressed and that all relevant stakeholders must be involved in the definition and management of health problems. International efforts ...
DOI:: 10.1016/j.prevetmed.2018.10.005
: https://doi.org/10.1016/j.prevetmed.2018.10.005

54. Characterization of casein and alpha lactalbumin of African elephant (Loxodonta africana) milk

Author:: M. Madende; G. Osthoff; H-G. Patterton; H.E. Patterton; P. Martin; D.J. Opperman
Source:: Journal of dairy science 2015 v.98 no.12 pp. 8308-8318
ISSN:: 0022-0302
Subject:: Loxodonta africana; alcohols; alpha-casein; amino acid sequences; beta-casein; cattle; crystal structure; dairy animals; databases; functional properties; humans; hydrophilicity; kappa-casein; lactalbumin; lactose; mammary glands; micelles; milk; models; nucleotide sequences; sequence alignment; whey protein
Abstract:: ... The current research reports partial characterization of the caseins and α-lactalbumin (α-LA) of the African elephant with proposed unique structure-function properties. Extensive research has been carried out to understand the structure of the casein micelles. Crystallographic structure elucidation of caseins and casein micelles is not possible. Consequently, several models have been developed in ...
DOI:: 10.3168/jds.2014-9195
: https://doi.org/10.3168/jds.2014-9195

55. Characterization of dextran-grafted hydrophobic charge-induction resins: Structural properties, protein adsorption and transport

Author:: Tao Liu; James M. Angelo; Dong-Qiang Lin; Abraham M. Lenhoff; Shan-Jing Yao
Source:: Journal of chromatography 2017 pp. -
ISSN:: 0021-9673
Subject:: adsorption; agarose; bovine serum albumin; confocal laser scanning microscopy; dextran; functional properties; gel chromatography; humans; hydrophobicity; immunoglobulin G; ligands; resins; salt concentration; salt tolerance; sorption isotherms
Abstract:: ... The structural and functional properties of a series of dextran-grafted and non-grafted hydrophobic charge-induction chromatographic (HCIC) agarose resins were characterized by macroscopic and microscopic techniques. The effects of dextran grafting and mobile phase conditions on the pore dimensions of the resins were investigated with inverse size exclusion chromatography (ISEC). A significantly l ...
DOI:: 10.1016/j.chroma.2017.07.090
: https://doi.org/10.1016/j.chroma.2017.07.090

56. Characterization of functional properties of Enterococcus faecium strains isolated from human gut

Author:: Hümeyra İspirli; Fatmanur Demirbaş; Enes Dertli
Source:: Canadian journal of microbiology 2015 v.61 no.11 pp. 861-870
ISSN:: 1480-3275
Subject:: Enterococcus faecium; acid tolerance; adhesion; anti-infective properties; antibiotic resistance; bacteriocins; bile salts; digestive system; enzymatic treatment; feces; functional properties; genes; heat treatment; hemolysis; hexadecane; humans; in vitro digestion; metabolism; pH; pathogens; polymerase chain reaction; probiotics; proteolysis; screening; vancomycin; virulence
Abstract:: ... The aim of this work was to characterize the functional properties of Enterococcus faecium strains identified after isolation from human faeces. Of these isolates, strain R13 showed the best resistance to low pH, bile salts, and survival in the simulated in vitro digestion assay, and demonstrated an important level of adhesion to hexadecane as a potential probiotic candidate. Analysis of the antib ...
DOI:: 10.1139/cjm-2015-0446
: https://doi.org/10.1139/cjm-2015-0446

57. Characterization of human leukocyte-HUVEC adhesion: Effect of cell preparation methods

Author:: Franca Marino; Laura Schembri; Emanuela Rasini; Monica Pinoli; Angela Scanzano; Alessandra Luini; Terenzio Congiu; Marco Cosentino
Source:: Journal of Immunological Methods 2017 v.443 pp. 55-63
ISSN:: 0022-1759
Subject:: adhesion; blood sampling; cell adhesion; coculture; endothelial cells; flow cytometry; functional properties; granulocytes; humans; in vitro studies; intercellular adhesion molecule-1; light microscopy; scanning electron microscopy; tumor necrosis factor-alpha
Abstract:: ... Sample manipulation to obtain isolated granulocytes represents a key, and often necessary, step in the in vitro studies. We investigated by the means of flow cytometry and microscopic techniques (both optical microscopy [OM] and scanning electron microscopy [SEM]), the granulocyte-endothelium adhesion and the role of sample manipulation.By means of a co-culture method, we have analysed the adhesio ...
DOI:: 10.1016/j.jim.2017.01.013
: https://doi.org/10.1016/j.jim.2017.01.013

58. Characterization of hyaluronic acid specific hyaluronate lyase (HylP) from Streptococcus pyogenes

Author:: Sudhir Kumar Singh; Soniya Malhotra; Md. Sohail Akhtar
Source:: Biochimie 2014 v.102 pp. 203-210
ISSN:: 0300-9084
Subject:: Escherichia coli; Streptococcus pyogenes; amino acids; bacteriophages; calcium; enzyme activity; functional properties; humans; hyaluronic acid; ions; mutation; toxigenic strains; virulence
Abstract:: ... Streptococcus pyogenes is associated with a wide variety of mucosal and invasive infections that claim human life. The conversion from non pathogenic to toxigenic strain of S. pyogenes are thought to be mediated by bacteriophage infection in several cases. The hyaluronic acid (HA) degrading enzyme Hyaluronate lyase (HL) is proposed to be one of the key bacteriophage-encoded virulence factors. In t ...
DOI:: 10.1016/j.biochi.2014.03.012
: https://doi.org/10.1016/j.biochi.2014.03.012

59. Characterization of the fundamental properties of the N-terminal truncation (Δ exon 1) variant of estrogen receptor α in the rat

Author:: Yujiro Hattori; Hirotaka Ishii; Akio Morita; Yasuo Sakuma; Hitoshi Ozawa
Source:: Gene 2015 v.571 pp. 117-125
ISSN:: 0378-1119
Subject:: messenger RNA; alternative splicing; transcriptional activation; estrogen receptors; humans; luciferase; reverse transcriptase polymerase chain reaction; transcription (genetics); mice; functional properties; rats; exons
Abstract:: ... The estrogen receptor α (ERα) directs transactivation of target genes, and splice variants have been shown to exhibit altered activation properties. We previously documented the complicated alternative promoter usage and splicing patterns of the rat ERα gene; however, the information was restricted to a few specific organs. Therefore, we re-examined the rat mRNA profiles of ERα, including the gene ...
DOI:: 10.1016/j.gene.2015.06.086
: https://doi.org/10.1016/j.gene.2015.06.086

60. Characterization of the neuraminidase of the H1N1/09 pandemic influenza virus

Author:: T. Gerlach; L. Kühling; J. Uhlendorff; V. Laukemper; T. Matrosovich; V. Czudai-Matwich; F. Schwalm; H.-D. Klenk; M. Matrosovich
Source:: Vaccine 2012 v.30 no.51 pp. 7348-7352
ISSN:: 0264-410X
Subject:: Orthomyxoviridae; birds; erythrocytes; functional properties; genes; humans; hydrolysis; mucins; neutralization; pandemic; sialidase; swine; vaccines; vertebrate viruses; viruses
Abstract:: ... In this study, we compared properties of the neuraminidase (NA) of the H1N1/2009 pandemic virus (H1N1pdm) and N1 NAs of other influenza viruses. The H1N1pdm NA was more active than NAs of seasonal H1N1 viruses, hydrolyzed Neu5Acα2-3Gal linkage as efficiently as did avian viruses and cleaved Neu5Acα2-6Gal linkage as efficiently as classical swine viruses. To assess the functional balance between he ...
DOI:: 10.1016/j.vaccine.2012.09.078
: https://doi.org/10.1016/j.vaccine.2012.09.078

61. Cheeses as food matrixes for probiotics: In vitro and in vivo tests

Author:: Fernanda R.L. Rolim; Oliveiro C. Freitas Neto; Maria Elieidy G. Oliveira; Celso J.B. Oliveira; Rita C.R.E. Queiroga
Source:: Trends in food science & technology 2020 v.100 pp. 138-154
ISSN:: 0924-2244
Subject:: buffering capacity; cheeses; clinical trials; food matrix; foods; functional properties; humans; in vitro studies; in vivo studies; intestinal mucosa; mechanism of action; nutrient availability; oxygen; pH; probiotics; sensory properties; shelf life; viability
Abstract:: ... Probiotics are microorganisms that promote beneficial health effects. To do this, they must survive passage through the gastrointestinal tract, adhere and colonize in the intestinal epithelium. Foods are vehicles that protect these strains during this passage, in particular cheese, which has advantages such as availability of nutrients, high pH, higher buffering capacity and low oxygen content. Th ...
DOI:: 10.1016/j.tifs.2020.04.008
: https://doi.org/10.1016/j.tifs.2020.04.008

62. Chemical profile, antiproliferative, antioxidant and enzyme inhibition activities of Ocimum basilicum L. and Pulicaria undulata (L.) C.A. Mey. grown in Sudan

Author:: Atif B.A. Mohammed; Sakina Yagi; Tzvetomira Tzanova; Hervé Schohn; Haider Abdelgadir; Azzurra Stefanucci; Adriano Mollica; Mohamad Fawzi Mahomoodally; Talal A. Adlan; Gökhan Zengin
Source:: South African journal of botany 2020 v.132 pp. 403-409
ISSN:: 0254-6299
Subject:: Ocimum basilicum; Pulicaria undulata; acarbose; acetylcholinesterase; adenocarcinoma; alpha-amylase; antioxidant activity; antioxidants; assays; breast neoplasms; cell lines; cell viability; chemical composition; cholinesterase; colon; computer simulation; cosmetics; enzyme activity; enzyme inhibition; essential oils; free radicals; functional properties; gas chromatography-mass spectrometry; humans; ions; linalool; methyl chavicol; oils; pharmaceutical industry; stems; Sudan
Abstract:: ... In the present study, essential oils extracted from the leafy stems of Ocimum basilicum (Family Lamiaceae) and Pulicaria undulata (Family Asteraceae) were investigated for their chemical profiles and biological activity including antioxidant, antiproliferative and enzyme inhibition activities. The chemical composition of essential oil was determined using Gas Chromatography-Mass Spectrometry. The ...
DOI:: 10.1016/j.sajb.2020.06.006
: https://doi.org/10.1016/j.sajb.2020.06.006

63. Chimeric proteins constructed from bacteriophage T7 gp4 and a putative primase–helicase from Arabidopsis thaliana

Author:: Jamie B. Towle-Weicksel; Yun Cao; Lisa J. Crislip; David L. Thurlow; Donald J. Crampton
Source:: Molecular biology reports 2014 v.41 no.12 pp. 7783-7795
ISSN:: 0301-4851
Subject:: Arabidopsis thaliana; DNA helicases; DNA-directed DNA polymerase; DNA-directed RNA polymerase; Escherichia coli; bacteriophages; chimerism; functional properties; humans; mitochondrial DNA; open reading frames; proteins; zinc
Abstract:: ... An open reading frame from Arabidopsis thaliana, which is highly homologous to the human mitochondrial DNA helicase TWINKLE, was previously cloned, expressed, and shown to have DNA primase and DNA helicase activity. The level of DNA primase activity of this Arabidopsis Twinkle homolog (ATH) was low, perhaps due to an incomplete zinc binding domain (ZBD). In this study, N-terminal truncations of AT ...
DOI:: 10.1007/s11033-014-3671-y
: https://doi.org/10.1007/s11033-014-3671-y

64. Cinnamomum cassia essential oil and its major constituent cinnamaldehyde induced cell cycle arrest and apoptosis in human oral squamous cell carcinoma HSC‐3 cells

Author:: Wen‐Lun Chang; Fu‐Chou Cheng; Shu‐Ping Wang; Su‐Tze Chou; Ying Shih
Source:: Environmental toxicology 2017 v.32 no.2 pp. 456-468
ISSN:: 1520-4081
Subject:: Cinnamomum aromaticum; DNA; DNA damage; antineoplastic activity; apoptosis; calcium; cell cycle checkpoints; cell viability; chromatin; cytochrome c; enzyme activity; essential oils; functional properties; glutathione; glutathione peroxidase; humans; membrane potential; mitochondria; mitochondrial membrane; reactive oxygen species; squamous cell carcinoma; thiobarbituric acid-reactive substances
Abstract:: ... Cinnamomum cassia essential oil (CC‐EO) has various functional properties, such as anti‐microbial, hypouricemic, anti‐tyrosinase and anti‐melanogenesis activities. The present study aimed to evaluate the anti‐cancer activities of CC‐EO and its major constituent, cinnamaldehyde, in human oral squamous cell carcinoma HSC‐3 cells. Determination of the cell viability, apoptotic characteristics, DNA da ...
DOI:: 10.1002/tox.22250
: https://doi.org/10.1002/tox.22250

65. Clitoria ternatea L. petal bioactive compounds display antioxidant, antihemolytic and antihypertensive effects, inhibit α-amylase and α-glucosidase activities and reduce human LDL cholesterol and DNA induced oxidation

Author:: Graziela Bragueto Escher; Mariza Boscacci Marques; Mariana Araújo Vieira do Carmo; Luciana Azevedo; Marianna Miranda Furtado; Anderson S. Sant'Ana; Marcia Cristina da Silva; Maria Inês Genovese; Mingchun Wen; Liang Zhang; Won Young Oh; Fereidoon Shahidi; Neiva Deliberali Rosso; Daniel Granato
Source:: Food research international 2020 v.128 pp. 108763
ISSN:: 0963-9969
Subject:: Clitoria ternatea; DNA; absorption; alpha-amylase; alpha-glucosidase; antihypertensive effect; antimicrobial properties; antioxidant activity; bioactive compounds; cell lines; cleavage (chemistry); corolla; cytotoxicity; enzyme activity; enzyme inhibition; erythrocytes; freeze drying; functional properties; hemolysis; humans; inhibitory concentration 50; lethal concentration 50; lipid peroxidation; low density lipoprotein cholesterol; oxidation; phenolic compounds; principal component analysis; protective effect; reactive oxygen species; temperature
Abstract:: ... The purpose of this study was to use a statistical approach to optimise the experimental conditions regarding the extraction of bioactive compounds, and to analyse the in vitro functional properties of crude lyophilized extracts (CLE) and partially purified (PPE) extracts of Clitoria ternatea petals. The results showed that the factors of temperature and time influenced the extraction of phenolic ...
DOI:: 10.1016/j.foodres.2019.108763
: https://doi.org/10.1016/j.foodres.2019.108763

66. Comparability studies of new 3rd generation recombinant human factor VIII GreenGene F after improvement of formulation and viral inactivation/removal process

Author:: Sang Hoon Paik; Yong Jae Kim; Sang Kyul Han; Ji-youn Kim; Hanna Park; Young In Park
Source:: Biologicals 2012 v.40 no.6 pp. 405-414
ISSN:: 1045-1056
Subject:: World Health Organization; clinical trials; factor VIII; functional properties; humans; intravenous injection; manufacturing; mice; nanofiltration; pathogens; peptides; risk; solvents; toxicity; viruses; South Korea
Abstract:: ... A new 3rd generation recombinant factor VIII (rFVIII), GreenGene F (WHO INN: beroctocog alfa), which is a highly homogenous B-domain deleted FVIII protein comprising of two peptides as heavy chain (A1 and A2 domain) and light chain (A3, C1, and C2 domain) at 80 and 90 kDa, was developed from its predecessor product GreenGene (2nd generation product previously approved by Korea FDA after clinical s ...
DOI:: 10.1016/j.biologicals.2012.09.004
: https://doi.org/10.1016/j.biologicals.2012.09.004

67. Comparative and bioinformatics analyses of pathogenic bacterial secretomes identified by mass spectrometry in Burkholderia species

Author:: Thao Thi Nguyen; Tae-Soo Chon; Jaehan Kim; Young-Su Seo; Muyoung Heo
Source:: journal of microbiology 2017 v.55 no.7 pp. 568-582
ISSN:: 1225-8873
Subject:: Burkholderia glumae; Markov chain; bioinformatics; blight; data collection; functional properties; hosts; humans; hydrophobicity; inflorescences; mass spectrometry; pathogenesis; plant pathogens; protein secretion; proteins; rice; seedlings
Abstract:: ... Secreted proteins (secretomes) play crucial roles during bacterial pathogenesis in both plant and human hosts. The identification and characterization of secretomes in the two plant pathogens Burkholderia glumae BGR1 and B. gladioli BSR3, which cause diseases in rice such as seedling blight, panicle blight, and grain rot, are important steps to not only understand the disease-causing mechanisms bu ...
DOI:: 10.1007/s12275-017-7085-0
: https://doi.org/10.1007/s12275-017-7085-0

68. Comparative functional characterization of canine IgG subclasses

Author:: Lisa M. Bergeron; Erin E. McCandless; Steve Dunham; Bill Dunkle; Yaqi Zhu; John Shelly; Sandra Lightle; Andrea Gonzales; Graeme Bainbridge
Source:: Veterinary immunology and immunopathology 2014 v.157 no.1-2 pp. 31-41
ISSN:: 0165-2427
Subject:: chimerism; complement; cytotoxicity; dogs; functional properties; humans; immune system; immunoglobulin G; monoclonal antibodies; receptors; veterinary medicine
Abstract:: ... To date, very little is known about the functional characteristics of the four published canine IgG subclasses. It is not clear how each subclass engages the immune system via complement-dependent cytotoxicity (CDC) or antibody-dependent cell-mediated cytotoxicity (ADCC), or how long each antibody may last in serum. Such information is critical for understanding canine immunology and for the disco ...
DOI:: 10.1016/j.vetimm.2013.10.018
: https://doi.org/10.1016/j.vetimm.2013.10.018

69. Comparative studies on osmosis based encapsulation of sodium diclofenac in porcine and outdated human erythrocyte ghosts

Author:: Katarina Bukara; Ivana Drvenica; Vesna Ilić; Ana Stančić; Danijela Mišić; Borislav Vasić; Radoš Gajić; Dušan Vučetić; Filip Kiekens; Branko Bugarski
Source:: Journal of biotechnology 2016 v.240 pp. 14-22
ISSN:: 0168-1656
Subject:: Fourier transform infrared spectroscopy; chemical reactions; diclofenac; drug delivery systems; drugs; encapsulation; erythrocytes; functional properties; hemolysis; humans; lipids; osmosis; potassium; slaughterhouses; surface roughness; swine
Abstract:: ... The objective of our study was to develop controlled drug delivery system based on erythrocyte ghosts for amphiphilic compound sodium diclofenac considering the differences between erythrocytes derived from two readily available materials – porcine slaughterhouse and outdated transfusion human blood. Starting erythrocytes, empty erythrocyte ghosts and diclofenac loaded ghosts were compared in term ...
DOI:: 10.1016/j.jbiotec.2016.10.017
: https://doi.org/10.1016/j.jbiotec.2016.10.017

70. Comparative studies on the heterogeneity of plasma-derived and recombinant human albumins in laboratory use

Author:: Takeshi Minami; Tomoyoshi Terada; Teppei Takahashi; Hajime Arikawa; Yukie Matsuyama; Kazuha Kizaki; Seiichi Era
Source:: International journal of biological macromolecules 2014 v.69 pp. 79-87
ISSN:: 0141-8130
Subject:: cell growth; denaturation; fatty acids; fractionation; functional properties; human serum albumin; humans; rice; thermal stability
Abstract:: ... We investigated the thiol-redox state, and the relationship between structural characteristics, such as thermal stability, and functional properties, such as cell growth activity, of commercial plasma-derived (pHSA) and recombinant human serum albumin (rHSA) products. In this study, 5 pHSA products (A1653, A9511, A1887, A8763, and A3782) and 2 rHSA products (A9731 and A9986) were obtained from Sig ...
DOI:: 10.1016/j.ijbiomac.2014.05.010
: https://doi.org/10.1016/j.ijbiomac.2014.05.010

71. Composition, antibacterial, antioxidant and antiproliferative activities of essential oils from three Origanum species growing wild in Lebanon and Greece

Author:: Mariangela Marrelli; Filomena Conforti; Carmen Formisano; Daniela Rigano; Nelly Apostolides Arnold; Francesco Menichini; Felice Senatore
Source:: Natural product research 2016 v.30 no.6 pp. 735-739
ISSN:: 1478-6427
Subject:: Escherichia coli; Gram-positive bacteria; Origanum dictamnus; antioxidant activity; antioxidants; carvacrol; essential oils; flavor; food quality; functional foods; functional properties; gamma-terpinene; gas chromatography-mass spectrometry; humans; linalool; oils; p-cymene; Greece; Lebanon
Abstract:: ... The essential oils from Origanum dictamnus , Origanum libanoticum and Origanum microphyllum were analysed by GC-MS, finding carvacrol, p-cymene, linalool, γ-terpinene and terpinen-4-ol as major components. The antioxidant activity by the DPPH and FRAP tests and the antiproliferative activity against two human cancer cell lines, LoVo and HepG2, were investigated, showing that the essential oil of O ...
DOI:: 10.1080/14786419.2015.1040993
: https://doi.org/10.1080/14786419.2015.1040993

72. Compositional and functional characterisation of poppy seed (Papaver somniferum L.) press cake meals

Author:: E. Yılmaz; D. Dündar Emir
Source:: Quality assurance and safety of crops & foods 2017 v.9 no.2 pp. 141-151
ISSN:: 1757-837X
Subject:: Papaver somniferum; calcium; cold; emulsifying; emulsifying properties; emulsions; enzymatic treatment; foaming; foaming capacity; foams; gelation; humans; magnesium; minerals; oilmeals; oils; phytic acid; potassium; quality control; roasting; seeds; sodium; viscosity; water holding capacity; zinc
Abstract:: ... In this study, three registered poppy seed varieties (Ofis 3, Ofis 4 and Ofis 8) were used. The compositional and functional properties of the defatted meals (cakes) obtained from previously treated (pre-roasting and enzyme treatment against control) and cold pressed poppy seeds were determined. Moisture (11.01-16.21%), protein (26.87-35.14%), oil (2.32-4.28%), ash (8.70-11.14%), hunter lab L (40. ...
DOI:: 10.3920/QAS2016.0863
: https://doi.org/10.3920/QAS2016.0863

73. Conformational Entropy as a Determinant of the Thermodynamic Stability of the p53 Core Domain

Author:: Aritra Bej; Juhi A. Rasquinha; Sujoy Mukherjee
Source:: Biochemistry 2018 v.57 no.44 pp. 6265-6269
ISSN:: 1520-4995
Subject:: Gibbs free energy; denaturation; entropy; functional properties; humans; molecular dynamics; mutants; mutation; neoplasms; nuclear magnetic resonance spectroscopy; regression analysis; simulation models; therapeutics; tumor suppressor protein p53; urea
Abstract:: ... Mutations in the core domain of tumor suppressor protein p53 have been associated with ∼50% of the occurrences of human cancers. A majority of these mutations inactivate p53 function by destabilizing its native structure. Although studies have shown p53’s function can be restored by stabilizing the mutants to their wild-type conformation with immense therapeutic potential, its applicability has be ...
DOI:: 10.1021/acs.biochem.8b00740
: https://doi.org/10.1021/acs.biochem.8b00740

74. Conserved functional characteristics of the PIWI family members in chicken germ cell lineage

Author:: T.H. Kim; T.W. Yun; D. Rengaraj; S.I. Lee; S.M. Lim; H.W. Seo; T.S. Park; J.Y. Han
Source:: Theriogenology 2012 v.78 no.9 pp. 1948-1959
ISSN:: 0093-691X
Subject:: RNA interference; genes; ribonucleases; males; gene expression; testes; embryogenesis; females; in situ hybridization; messenger RNA; complementary DNA; humans; mice; stem cells; cDNA libraries; chickens; quantitative polymerase chain reaction; proteins; germ cells; reverse transcriptase polymerase chain reaction; functional properties
Abstract:: ... The P-element-induced wimpy testis (PIWI) protein family, one of two subfamily members of Argonautes that regulate gene expression by associating with small noncoding RNAs, plays a role in maintaining the integrity of germ cells and stem cells. PIWI proteins have been identified and characterized in many species, including humans, mice, and zebrafish, but not as yet in avian species. In this study ...
DOI:: 10.1016/j.theriogenology.2012.07.019
PubMed:: 23058791
: https://doi.org/10.1016/j.theriogenology.2012.07.019

75. Coupling of disulfide bond and distal histidine dissociation in human ferrous cytoglobin regulates ligand binding

Author:: Penny Beckerson; Brandon J. Reeder; Michael T. Wilson
Source:: FEBS letters 2015 v.589 no.4 pp. 507-512
ISSN:: 0014-5793
Subject:: cysteine; dissociation; disulfide bonds; functional properties; histidine; humans; ligands; models; mutants; photolysis
Abstract:: ... Earlier kinetics studies on cytoglobin did not assign functional properties to specific structural forms. Here, we used defined monomeric and dimeric forms and cysteine mutants to show that an intramolecular disulfide bond (C38–C83) alters the dissociation rate constant of the intrinsic histidine (H81) (∼1000fold), thus controlling binding of extrinsic ligands. Through time-resolved spectra we hav ...
DOI:: 10.1016/j.febslet.2015.01.010
: https://doi.org/10.1016/j.febslet.2015.01.010

76. Cow’s milk as a dietary source of equol and phenolic antioxidants: differential distribution in the milk aqueous and lipid fractions

Author:: Shin Yih Tsen; Jinyi Siew; Eunice Kai Ling Lau; Farzana Afiqah bte Roslee; Hui Mei Chan; Wai Mun Loke
Source:: Dairy science & technology 2014 v.94 no.6 pp. 625-632
ISSN:: 1958-5586
Subject:: antioxidant activity; antioxidants; bacteria; correlation; cows; daidzein; digestive system; functional properties; humans; metabolites; milk; neutrophils; nutritive value; phenolic compounds
Abstract:: ... Cow’s milk contains bioactive secondary phenolic compounds that are formed by bovine’s gut bacterial flora from plant phenolic compounds. Equol, a metabolite of daidzein, is one such secondary compounds of biological interest. The potential of phenolic compounds in milk as dietary antioxidants and their distribution within the milk matrix were examined. The equol concentrations, total phenolic con ...
DOI:: 10.1007/s13594-014-0183-4
: https://doi.org/10.1007/s13594-014-0183-4

77. Crystal structure and functional characterization of selenocysteine-containing glutathione peroxidase 4 suggests an alternative mechanism of peroxide reduction

Author:: Astrid Borchert; Jacqueline Kalms; Sophia R. Roth; Marlena Rademacher; Andrea Schmidt; Hermann-Georg Holzhutter; Hartmut Kuhn; Patrick Scheerer
Source:: Biochimica et biophysica acta 2018 v.1863 no.9 pp. 1095-1107
ISSN:: 1388-1981
Subject:: Escherichia coli; X-radiation; alcohols; crystal structure; electrophoresis; enzymology; functional properties; genes; glutathione; glutathione peroxidase; humans; hydroperoxides; mice; phospholipid-hydroperoxide glutathione peroxidase; phospholipids; reaction mechanisms; selenium; selenocysteine; selenoproteins; transgenic animals
Abstract:: ... Glutathione peroxidases (GPX) are anti-oxidative enzymes that reduce organic and inorganic hydroperoxides to the corresponding alcohols at the expense of reduced glutathione. The human genome involves eight GPX genes and five of them encode for selenocysteine-containing enzymes. Among the human GPX-isoforms, GPX4 is unique since it is capable of reducing complex hydroperoxy ester lipids such as hy ...
DOI:: 10.1016/j.bbalip.2018.06.006
: https://doi.org/10.1016/j.bbalip.2018.06.006

78. Crystal structure of the kinase domain of human protein tyrosine kinase 6 (PTK6) at 2.33 Å resolution

Author:: Manish Kumar Thakur; Amit Kumar; Swarnakumari Birudukota; Srinivasan Swaminathan; Rajiv Tyagi; Ramachandraiah Gosu
Source:: Biochemical and biophysical research communications 2016 v.478 no.2 pp. 637-642
ISSN:: 0006-291X
Subject:: X-ray diffraction; ambient temperature; breast neoplasms; cell lines; crystal structure; databases; functional properties; humans; mammary glands; molecular cloning; neoplasm cells; solvents; therapeutics; tyrosine
Abstract:: ... Human Protein tyrosine kinase 6 (PTK6) (EC:2.7.10.2), also known as the breast tumor kinase (BRK), is an intracellular non-receptor Src-related tyrosine kinase expressed in a majority of human breast tumors and breast cancer cell lines, but its expression is low or completely absent in normal mammary glands. In the recent past, several studies have suggested that PTK6 is a potential therapeutic ta ...
DOI:: 10.1016/j.bbrc.2016.07.121
: https://doi.org/10.1016/j.bbrc.2016.07.121

79. Crystal structure of the rigor-like human non-muscle myosin-2 motor domain

Author:: Stefan Münnich; Salma Pathan-Chhatbar; Dietmar J. Manstein
Source:: FEBS letters 2014 v.588 no.24 pp. 4754-4760
ISSN:: 0014-5793
Subject:: actin; active sites; crystal structure; functional properties; humans; mutation; myosin
Abstract:: ... We determined the crystal structure of the motor domain of human non-muscle myosin 2B (NM-2B) in a nucleotide-free state and at a resolution of 2.8Å. The structure shows the motor domain with an open active site and the large cleft that divides the 50kDa domain in a closed state. Compared to other rigor-like myosin motor domain structures, our structure shows subtle but significant conformational ...
DOI:: 10.1016/j.febslet.2014.11.007
: https://doi.org/10.1016/j.febslet.2014.11.007

80. Current and Future Technologies for Microbiological Decontamination of Cereal Grains

Author:: Agata Los; Dana Ziuzina; Paula Bourke
Source:: Journal of food science 2018 v.83 no.6 pp. 1484-1493
ISSN:: 0022-1147
Subject:: decontamination; food safety; functional properties; human health; humans; microorganisms; mycotoxins; pesticides; population growth; risk; small cereal grains; staple foods
Abstract:: ... Cereal grains are the most important staple foods for mankind worldwide. The constantly increasing annual production and yield is matched by demand for cereals, which is expected to increase drastically along with the global population growth. A critical food safety and quality issue is to minimize the microbiological contamination of grains as it affects cereals both quantitatively and qualitativ ...
DOI:: 10.1111/1750-3841.14181
: https://doi.org/10.1111/1750-3841.14181

81. Cysteine 180 Is a Redox Sensor Modulating the Activity of Human Pyridoxal 5′-Phosphate Histidine Decarboxylase

Author:: Giada Rossignoli; Alessandro Grottesi; Giovanni Bisello; Riccardo Montioli; Carla Borri Voltattorni; Alessandro Paiardini; Mariarita Bertoldi
Source:: Biochemistry 2018 v.57 no.44 pp. 6336-6348
ISSN:: 1520-4995
Subject:: active sites; amino acid sequences; bioactive compounds; bioinformatics; cell growth; cysteine; functional properties; gastrointestinal system; histamine; histidine; histidine decarboxylase; humans; molecular dynamics; oxidation; protein content; pyridoxal; pyridoxal phosphate; reducing agents; simulation models
Abstract:: ... Histidine decarboxylase is a pyridoxal 5′-phosphate enzyme catalyzing the conversion of histidine to histamine, a bioactive molecule exerting its role in many modulatory processes. The human enzyme is involved in many physiological functions, such as neurotransmission, gastrointestinal track function, cell growth, and differentiation. Here, we studied the functional properties of the human enzyme ...
DOI:: 10.1021/acs.biochem.8b00625
: https://doi.org/10.1021/acs.biochem.8b00625

82. DNA-based analysis of protein variants reveals different genetic variability of the paralogous equine ß-lactoglobulin genes LGB1 and LGB2

Author:: J. Brinkmann; V. Jagannathan; C. Drögemüller; S. Rieder; T. Leeb; G. Thaller; J. Tetens
Source:: Livestock science 2016 v.187 pp. 181-185
ISSN:: 1871-1413
Subject:: allergens; beta-lactoglobulin; breast milk; breeds; functional properties; gene expression; genes; genetic variation; horses; humans; hypersensitivity; lipid content; low fat milk; mare milk; nutritive value; open reading frames; people; ruminants; signal peptide; whey protein
Abstract:: ... The genetic variability of milk protein genes may influence the nutritive value or processing and functional properties of the milk. While numerous protein variants are known in ruminants, knowledge about milk protein variability in horses is still limited. Mare's milk is, however, produced for human consumption in many countries. Beta-lactoglobulin belonging to the protein family of lipocalins, w ...
DOI:: 10.1016/j.livsci.2016.03.014
: https://doi.org/10.1016/j.livsci.2016.03.014

83. Date palm and saw palmetto seeds functional properties: antioxidant, anti-inflammatory and antimicrobial activities

Author:: Amal Z. Barakat; Ahmed R. Hamed; Roqaya I. Bassuiny; Azza M. Abdel-Aty; Saleh A. Mohamed
Source:: Journal of food measurement & characterization 2020 v.14 no.2 pp. 1064-1072
ISSN:: 2193-4126
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Phoenix dactylifera; Serenoa repens; acetone; agroindustrial byproducts; anti-inflammatory activity; antibacterial properties; antifungal properties; antioxidant activity; antioxidants; bioactive compounds; enzyme inhibition; ethanol; flavonoids; functional properties; fungi; high performance liquid chromatography; humans; inducible nitric oxide synthase; inflammation; inhibitory concentration 50; minimum inhibitory concentration; multiple drug resistance; nitric oxide; protein synthesis; protocatechuic acid; seeds
Abstract:: ... The agricultural by-products are a significant source of health benefiting bioactive compounds. In this trend, the phenolic and flavonoid contents and functional properties of date palm seeds (DPS) and saw palmetto seeds (SPS) extracts were evaluated in this study. Considerable phenolic and flavonoid contents of 11.8, 7.75 mg GAE/g seed and 3.13, 1.1 mg CE/g seed were detected in DPS ethanol and S ...
DOI:: 10.1007/s11694-019-00356-5
: https://doi.org/10.1007/s11694-019-00356-5

84. Defining the functional properties of dietary protein and protein-rich foods in human energy expenditure

Author:: TAN, Sze Yen; TAPSELL, Linda; BATTERHAM, Marijka; CHARLTON, Karen
Source:: Nutrition & dietetics 2008 v.65 no.s3 pp. S66
ISSN:: 1446-6368
Subject:: calorimeters; dietary protein; energy intake; functional properties; high protein diet; high protein foods; humans; nutritional intervention; omnivores; thermic effect of food; vegetarian diet; weight loss
Abstract:: ... Food has a number of functional properties that can support the balance between energy intake and energy expenditure and, theoretically, one of these is the thermic effect of food. Including high-protein foods in meals may be advantageous in contributing to energy expenditure but, in practice, the evidence needs to relate to specific foods and normal dietary conditions. Using the human whole room ...
DOI:: 10.1111/j.1747-0080.2008.00264.x
: https://doi.org/10.1111/j.1747-0080.2008.00264.x

85. Delineating the role of ionic interactions in structural and functional integrity of B. malayi Guanylate kinase

Author:: Smita Gupta; Venkatesan Suryanarayanan; Sunita Yadav; Sanjeev K. Singh; Jitendra K. Saxena
Source:: International journal of biological macromolecules 2017 v.98 pp. 357-365
ISSN:: 0141-8130
Subject:: active sites; dimerization; dissociation; enzyme activity; functional properties; humans; molecular dynamics; mutation; oligomerization; pH; salt concentration; sodium chloride
Abstract:: ... The present work deals with investigating the role of ionic interactions in the native conformation of BmGK by altering pH and salt concentration as well as by disruption of inter-subunit region. The study on structural and functional properties of BmGK as a function of pH showed that the secondary and tertiary elements of the protein were disturbed at low pH with loss of its native oligomerizatio ...
DOI:: 10.1016/j.ijbiomac.2017.01.098
: https://doi.org/10.1016/j.ijbiomac.2017.01.098

86. Design and humanization of a murine scFv that blocks human platelet glycoprotein VI in vitro

Author:: Muzard, Julien; Bouabdelli, Maxime; Zahid, Muhammad; Ollivier, Véronique; Lacapère, Jean Jacques; Jandrot-Perrus, Martine; Billiald, Philippe
Source:: FEBS journal 2009 v.276 no.15 pp. 4207-4222
ISSN:: 1742-464X
Subject:: adhesion; antibodies; bacteria; blood platelets; blood vessels; cell adhesion; collagen; functional properties; glycoproteins; hemorrhage; humans; immunoglobulin G; mice; models; platelet aggregation
Abstract:: ... Platelet adhesion and aggregation at the site of vascular injury is essential for hemostasis, but can also lead to arterial occlusion in thrombotic disorders. Glycoprotein (GP) VI is the major platelet membrane receptor that interacts directly with collagen, the most thrombogenic compound in the blood vessels. GPVI could therefore be a major therapeutic target. Fab fragments of the anti-GPVI murin ...
DOI:: 10.1111/j.1742-4658.2009.07129.x
PubMed:: 19558491
: https://doi.org/10.1111/j.1742-4658.2009.07129.x

87. Detecting the structural assembly pathway of human antimicrobial peptide pores at single-channel level

Author:: Neethu Puthumadathil; Poornendhu Jayasree; K. Santhosh Kumar; K. Madhavan Nampoothiri; Harsha Bajaj; Kozhinjampara R. Mahendran
Source:: Biomaterials science 2019 v.7 no.8 pp. 3226-3237
ISSN:: 2047-4849
Subject:: antimicrobial peptides; detergents; functional properties; humans; lipid bilayers; mechanism of action; micelles; molecular models; permeability; sodium dodecyl sulfate; therapeutics
Abstract:: ... The pore-forming structures of an anionic human antimicrobial peptide dermcidin (DCD) in a membrane environment has not been demonstrated previously. Using single-channel electrical recordings, we characterized the structural and functional properties of the DCD peptide channel in lipid membranes. We show that a 48-residue, 8 nm long anionic DCD-1L peptide is folded in the right conformation in so ...
DOI:: 10.1039/c9bm00181f
: https://doi.org/10.1039/c9bm00181f

88. Detoxification of ivermectin by ATP binding cassette transporter C4 and cytochrome P450 monooxygenase 6CJ1 in the human body louse, Pediculus humanus humanus

Author:: J. H. Kim; K. J. Gellatly; B. Lueke; M. Kohler; R. Nauen; E. Murenzi; K. S. Yoon; J. M. Clark
Source:: Insect molecular biology 2018 v.27 no.1 pp. 73-82
ISSN:: 0962-1075
Subject:: ABC transporters; Baculoviridae; DDT (pesticide); Pediculus humanus; adenine; cytochrome P-450; evolution; functional properties; genes; humans; insecticides; insects; ivermectin; lice; liquids; metabolism; oocytes; spectral analysis; tritium; xenobiotics
Abstract:: ... We previously observed that ivermectin‐induced detoxification genes, including ATP binding cassette transporter C4 (PhABCC4) and cytochrome P450 6CJ1 (CYP6CJ1) were identified from body lice following a brief exposure to a sublethal dose of ivermectin using a non‐invasive induction assay. In this current study, the functional properties of PhABCC4 and CYP6CJ1 were investigated after expression in ...
DOI:: 10.1111/imb.12348
: https://doi.org/10.1111/imb.12348

89. Development and comparison of in vivo and in vitro models for endometritis in cows and mares

Author:: Zerbe, H.; Schuberth, H.J.; Engelke, F.; Frank, J.; Klug, E.; Leibold, W.
Source:: Theriogenology 2003 v.60 no.2 pp. 209-223
ISSN:: 0093-691X
Subject:: cows; endometritis; functional properties; humans; in vitro studies; interleukin-8; mares; models; neutrophils; phenotype; reactive oxygen species; uterus
Abstract:: ... In order to investigate pathogenic mechanisms of acute endometritis in cows and mares, we established an in vivo model in both species. Based on the results of an in vitro transmigration system, human recombinant interleukin-8 (rhIL-8; 1.25μg per mare and 5μg per cow in 50ml phosphate-buffered saline) was used to attract polymorphonuclear neutrophil granulocytes (PMNs) into the uteri. Peak numbers ...

90. Development of new non-dairy beverages from Mediterranean fruit juices fermented with water kefir microorganisms

Author:: Walter Randazzo; Onofrio Corona; Rosa Guarcello; Nicola Francesca; Maria Antonietta Germanà; Hüseyin Erten; Giancarlo Moschetti; Luca Settanni
Source:: Food microbiology 2016 v.54 pp. 40-51
ISSN:: 0740-0020
Subject:: Opuntia; alcohols; aldehydes; antioxidant activity; apples; beverages; color; esters; fruit juices; fruits; functional properties; grapes; humans; kefir; kiwifruit; lactic acid; lactic acid bacteria; lactic fermentation; pomegranates; quinces; titratable acidity; total soluble solids; value added; volatile organic compounds; yeasts; Italy; Sicily
Abstract:: ... The aim of this work was to explore the use of several Mediterranean fruit juices as fermentable substrates to develop new non-dairy fermented beverages. Microbiological, chemical and sensory features of kefir-like beverages obtained after the fermentation of juices extracted from fruits cultivated in Sicily (southern Italy) with water kefir microorganisms were investigated. Results indicated that ...
DOI:: 10.1016/j.fm.2015.10.018
: https://doi.org/10.1016/j.fm.2015.10.018

91. Development, phenotype, and function of non-conventional B cells

Author:: J.M.B. Prieto; M.J.B. Felippe
Source:: Comparative immunology, microbiology, and infectious diseases 2017 v.54 pp. 38-44
ISSN:: 0147-9571
Subject:: B-lymphocytes; Primates; adaptive immunity; autoimmune diseases; cattle; functional properties; guinea pigs; homeostasis; horses; humans; immunoglobulin M; innate immunity; mice; phenotype; rabbits; secretion; swine; tissue distribution
Abstract:: ... Three populations of B cells develop in fetal life: B1, B2 and marginal zone B cells. B1 cells play important roles in innate immunity in contrast to B2 cells that perform the conventional roles in adaptive immunity. B1 cells were first identified in mice based on their expression of CD5 and spontaneous secretion of IgM. B1 cells were subsequently found to have unique developmental, phenotype, tis ...
DOI:: 10.1016/j.cimid.2017.08.002
: https://doi.org/10.1016/j.cimid.2017.08.002

92. Differential structure and activity between human and mouse intelectin-1: Human intelectin-1 is a disulfide-linked trimer, whereas mouse homologue is a monomer

Author:: Tsuji, Shoutaro; Yamashita, Makiko; Nishiyama, Akihito; Shinohara, Tsutomu; Li, Zhongwei; Myrvik, Quentin N.; Hoffman, Donald R.; Henriksen, Ruth Ann; Shibata, Yoshimi
Source:: Glycobiology 2007 v.17 no.10 pp. 1045-1051
ISSN:: 0959-6658
Subject:: adsorption; amino acids; cell walls; functional properties; humans; intestines; lectins; mice; microorganisms; oligosaccharides; recombinant proteins; tissues; xylose
Abstract:: ... Human intelectin-1 (hITLN-1) is a 120-kDa lectin recognizing galactofuranosyl residues found in cell walls of various microorganisms but not in mammalian tissues. Although mouse intelectin-1 (mITLN-1) has been identified previously, its biochemical properties and functional characteristics have not been studied. Therefore, we have compared structures and saccharide-binding specificities of hITLN-1 ...
DOI:: 10.1093/glycob/cwm075
: https://doi.org/10.1093/glycob/cwm075

93. Discovery of novel transcripts of the human tissue kallikrein (KLK1) and kallikrein-related peptidase 2 (KLK2) in human cancer cells, exploiting Next-Generation Sequencing technology

Author:: Panagiotis G. Adamopoulos; Christos K. Kontos; Andreas Scorilas
Source:: Genomics 2019 v.111 no.4 pp. 642-652
ISSN:: 0888-7543
Subject:: alternative splicing; bioinformatics; biomarkers; functional properties; genes; high-throughput nucleotide sequencing; humans; neoplasm cells; neoplasms; plasma kallikrein; polymerase chain reaction; tissue kallikrein
Abstract:: ... Tissue kallikrein, kallikrein-related peptidases (KLKs), and plasma kallikrein form the largest group of serine proteases in the human genome, sharing many structural and functional properties. Several KLK transcripts have been found aberrantly expressed in numerous human malignancies, confirming their prognostic or/and diagnostic values. However, the process of alternative splicing can now be stu ...
DOI:: 10.1016/j.ygeno.2018.03.022
: https://doi.org/10.1016/j.ygeno.2018.03.022

94. Dissecting the differential structural and dynamics features of CCL2 chemokine orthologs

Author:: Nidhi Joshi; Nupur Nagar; Khushboo Gulati; Krishnakant Gangele; Amit Mishra; Dinesh Kumar; Krishna Mohan Poluri
Source:: International journal of biological macromolecules 2020 v.156 pp. 239-251
ISSN:: 0141-8130
Subject:: Primates; Rodentia; cell movement; chemokine CCL2; comparative study; computer simulation; evolution; functional properties; glycosaminoglycans; glycosylation; humans; mice; monocytes; nuclear magnetic resonance spectroscopy; proteins
Abstract:: ... Chemokines are a sub-group of cytokines that regulate the leukocyte migration. Monocyte chemoattractant protein-1 (MCP/CCL2) is one of the essential CC chemokine that regulates the migration of monocytes into inflamed tissues. It has been observed that the primary sequences of CCL2 orthologs among rodents and primates vary significantly at the C-terminal region. However, no structural details are ...
DOI:: 10.1016/j.ijbiomac.2020.04.067
: https://doi.org/10.1016/j.ijbiomac.2020.04.067

95. Diversity in flowering plants and their characteristics: integrating humans as a driver of urban floral resources

Author:: David M. Lowenstein; Emily S. Minor
Source:: Urban ecosystems 2016 v.19 no.4 pp. 1735-1748
ISSN:: 1083-8155
Subject:: Hispanics; Trifolium repens; Whites; cities; community structure; demographic statistics; ecosystem services; flowers; functional properties; habitat conservation; humans; landscapes; lifestyle; low-income neighborhoods; ornamental plants; perennials; plant characteristics; plant communities; socioeconomic factors; species diversity; urban areas; weeds; Illinois
Abstract:: ... Urban neighborhoods vary in development intensity and in the life style and demographics of their residents. Decisions made by urban residents affect plant communities, their functional characteristics, and the floral resources they provide. We recorded flowers in front-facing yards in 58 neighborhoods in Chicago, IL (USA) and examined patterns in community composition and species turnover between ...
DOI:: 10.1007/s11252-016-0563-z
: https://doi.org/10.1007/s11252-016-0563-z

96. Diversity of human skeletal muscle in health and disease: Contribution of proteomics

Author:: Cecilia Gelfi; Michele Vasso; Paolo Cerretelli
Source:: Journal of proteomics 2011 v.74 no.6 pp. 774-795
ISSN:: 1874-3919
Subject:: actin; animal models; biomarkers; cold; enzymes; exercise; functional properties; humans; hypoxia; insulin resistance; muscles; myosin; myositis; patients; proteome; proteomics; skeletal muscle; tropomyosins
Abstract:: ... Muscle represents a large fraction of the human body mass. It is an extremely heterogeneous tissue featuring in its contractile structure various proportions of heavy- and light-chain slow type 1 and fast types 2A and 2X myosins, actins, tropomyosins, and troponin complexes as well as metabolic proteins (enzymes and most of the players of the so-called excitation–transcription coupling). Muscle is ...
DOI:: 10.1016/j.jprot.2011.02.028
PubMed:: 21414428
: https://doi.org/10.1016/j.jprot.2011.02.028

97. Diversity of reaction characteristics of glucan branching enzymes and the fine structure of α-glucan from various sources

Author:: Takayuki Sawada; Yasunori Nakamura; Takashi Ohdan; Asami Saitoh; Perigio B. Francisco; Eiji Suzuki; Naoko Fujita; Takahiro Shimonaga; Shoko Fujiwara; Mikio Tsuzuki; Christophe Colleoni; Steven Ball
Source:: Archives of biochemistry and biophysics 2014 v.562 pp. 9-21
ISSN:: 0003-9861
Subject:: 1,4-alpha-glucan branching enzyme; Escherichia coli; Parachlorella kessleri; Porphyridium; Synechococcus elongatus; branching; dextrins; functional properties; glucose; humans; isozymes; proteins; rice; yeasts
Abstract:: ... To investigate the functional properties of 10 α-glucan branching enzymes (BEs) from various sources, we determined the chain-length distribution of BE enzymatic products and their phosphorylase-limit dextrins (Φ-LD). All BEs could be classified into either of the three rice BE isozymes: OsBEI, OsBEIIa, or OsBEIIb. Escherichia coli BE (EcoBE) had the same enzymatic properties as OsBEI, while Synec ...
DOI:: 10.1016/j.abb.2014.07.032
: https://doi.org/10.1016/j.abb.2014.07.032

98. Dopaminergic induction of human dental pulp stem cells by photobiomodulation: comparison of 660nm laser light and polychromatic light in the nir

Author:: Merve Çapkın Yurtsever; Arlin Kiremitci; Menemşe Gümüşderelioğlu
Source:: Journal of photochemistry and photobiology 2020 v.204 pp. 111742
ISSN:: 1011-1344
Subject:: brain; cell death; cell lines; culture media; diodes; dopamine; energy density; functional properties; humans; laminin; messenger RNA; near infrared radiation; neuroglia; neurons; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; stem cells; tooth pulp
Abstract:: ... Human dental pulp stem cells (hDPSCs) are able to differentiate into dopaminergic neurons and help the maintenance of partially degenerated neurons, which makes them as an alternative cell source for treatment of Parkinsons' disease (PD) patients. Here, the effect of photobiomodulation with polychromatic light source in the near infrared (NIR) range (600–1200 nm) or low level 660 nm diode laser li ...
DOI:: 10.1016/j.jphotobiol.2019.111742
: https://doi.org/10.1016/j.jphotobiol.2019.111742

99. Edible insect protein for food applications: Extraction, composition, and functional properties

Author:: Benjamin K. Mintah; Ronghai He; Akwasi A. Agyekum; Mokhtar Dabbour; Moses K. Golly; Haile Ma
Source:: Journal of food process engineering 2020 v.43 no.4 pp. e13362
ISSN:: 0145-8876
Subject:: Hermetia illucens; amino acids; edible insects; experimental design; fluorescence; functional properties; humans; industry; insect larvae; insect proteins; mathematical models; pests; protein composition; protein isolates; protein sources; response surface methodology
Abstract:: ... This study sought to establish an optimized procedure for extraction of protein from microwave‐dried larvae of an edible insect, Hermetia illucens (HIL), and to determine and compare the amino acid (AA) component, intrinsic fluorescence (IF), and physicochemical/functional properties (PFPs) of protein isolates. Box–Behnken's design with the Box–Wilson methodology was applied in the optimization pr ...
DOI:: 10.1111/jfpe.13362
: https://doi.org/10.1111/jfpe.13362

100. Effect of Cold Plasma Treatment on the Functional Properties of Fresh-Cut Apples

Author:: lleana Ramazzina; Silvia Tappi; Pietro Rocculi; Giampiero Sacchetti; Annachiara Beradinelli; Angela Marseglia; Federica Rizzi
Source:: Journal of agricultural and food chemistry 2016 v.64 no.42 pp. 8010-8018
ISSN:: 0021-8561
Subject:: enzyme activation; polyphenols; apples; cell viability; fresh-cut produce; humans; reactive oxygen species; food industry; food preservation; bioactive compounds; cold; traditional foods; functional properties; antioxidant activity; oxidative stress
Abstract:: ... Atmospheric double-barrier discharge (DBD) plasma technology is a promising tool in the food industry as an alternative to traditional food preservation methods. However, the effect of the reactive species generated during the treatment on the content of bioactive compounds in food is still little studied, and there are no data concerning potential deleterious effects of DBD-treated foods on human ...
DOI:: 10.1021/acs.jafc.6b02730
: https://doi.org/10.1021/acs.jafc.6b02730

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1. 71. Cryopreservation of in vitroshoot-tips of a sweet potato Famaillá 6 clone (Ipomoea batatas (L.) Lam.) by droplet-vitrification technique

2. A Peptide Derived from Bovine β-Casein Modulates Functional Properties of Bone Marrow-Derived Macrophages from Germfree and Human Flora-Associated Mice

3. A Pursuit of the Functional Nutritional and Bioactive Properties of Canola Proteins and Peptides

4. A Review on Osmotic Dehydration of Fruits and Vegetables: An Integrated Approach

5. A Tn antigen binding lectin from Myrsine coriacea displays toxicity in human cancer cell lines

6. A bacterial 2[4Fe4S] ferredoxin as redox partner of the plastidic-type ferredoxin-NADP+ reductase from Leptospira interrogans

7. A biological trait approach to assess the functional composition of subtidal benthic communities in an estuarine ecosystem

8. A compendium on single‐cell analysis for the curious

9. A functionally conserved member of the FTZâF1 nuclear receptor family from Schistosoma mansoni

10. A microfluidically perfused three dimensional human liver model

11. A newly isolated probiotic Enterococcus faecalis strain from vagina microbiota enhances apoptosis of human cancer cells

12. A novel Kir7.1 splice variant expressed in various mouse tissues shares organisational and functional properties with human Leber amaurosis-causing mutations of this K+ channel

13. A novel bovine serum albumin and sodium alginate hydrogel scaffold doped with hydroxyapatite nanowires for cartilage defects repair

14. A novel non-integrative single-cycle chimeric HIV lentivector DNA vaccine

15. A novel splice variant of supervillin, SV5, promotes carcinoma cell proliferation and cell migration

16. A review: Health promoting lactic acid bacteria in traditional Indonesian fermented foods

17. A simple method of surface functionalisation for immuno-specific immobilisation of proteins

18. Advances in Studies Using Vegetable Wastes to Obtain Pectic Substances: A Review

19. Alginate/PVA Beads for Levan Production by Zymomonas mobilis

20. Altered response of fibroblasts from human tympanosclerotic membrane to interacting mast cells: Implication for tissue remodeling

21. An overview of plant-autochthonous microorganisms and fermented vegetable foods

22. An overview of separation methods in starch analysis: The importance of size exclusion chromatography and field flow fractionation

23. Analysis of Calcium Transients and Uniaxial Contraction Force in Single Human Embryonic Stem Cell-Derived Cardiomyocytes on Microstructured Elastic Substrate with Spatially Controlled Surface Chemistries

24. Analysis of Single-Nucleotide Polymorphisms in Human Voltage-Gated Ion Channels

25. Analysis of adenovirus-induced immunity to infection with Listeria monocytogenes: Fading protection coincides with declining CD8 T cell numbers and phenotypic changes

26. Analysis of functional properties of biologically active substances using eukaryotic cell models (review)

27. Antagonistic effect of chitinolytic Pseudomonas and Bacillus on growth of fungal hyphae and spores of aflatoxigenic Aspergillus flavus

28. Antioxidant and anticancer effects of functional peptides from ovotransferrin hydrolysates

29. Antioxidant, angiotensin-converting enzyme inhibitory activity and other functional properties of egg white proteins and their derived peptides – A review

30. Application and bioactive properties of proteins and peptides derived from hen eggs: opportunities and challenges

31. Application of diagnosticum based on functionalized carbon nanoparticles for monitoring of immunoglobulins affinity purification

32. Artificial structures alter kelp functioning across an urbanised estuary

33. Association of human tumor necrosis factor‐related apoptosis inducing ligand with membrane upon acidification

34. Barley yellow dwarf viruses (BYDVs) preserved in herbarium specimens illuminate historical disease ecology of invasive and native grasses

35. Beyond spectral tuning: human cone visual pigments adopt different transient conformations for chromophore regeneration

36. Bioactive properties and functional constituents of Hypericum androsaemum L.: A focus on the phenolic profile

37. Bioactivity of soy-based fermented foods: A review

38. Biomechanical and functional properties of trophoblast cells exposed to Group B Streptococcus in vitro and the beneficial effects of uvaol treatment

39. Biomimetic LBL structured nanofibrous matrices assembled by chitosan/collagen for promoting wound healing

40. Biomimetic cardiovascular platforms for in vitro disease modeling and therapeutic validation

41. Biopolymer-based coacervates: Structures, functionality and applications in food products

42. Bioprocessing of human mesenchymal stem/stromal cells for therapeutic use: Current technologies and challenges

43. Biosynthesis of dextran by Weissella confusa and its In vitro functional characteristics

44. Black Pepper and Health Claims: A Comprehensive Treatise

45. C-termini are essential and distinct for nucleic acid binding of human NABP1 and NABP2

46. CD11c⁺ Cells are Significantly Decreased in the Duodenum, Ileum and Colon of Dogs with Inflammatory Bowel Disease

47. CLERC and centrosomal leucine-rich repeat proteins

48. Calmodulin mutations causing catecholaminergic polymorphic ventricular tachycardia confer opposing functional and biophysical molecular changes

49. Camu-camu seed (Myrciaria dubia) – From side stream to an antioxidant, antihyperglycemic, antiproliferative, antimicrobial, antihemolytic, anti-inflammatory, and antihypertensive ingredient

50. Cardiac tissue engineering using tissue printing technology and human cardiac progenitor cells

51. Cardioprotective properties of grape seed proanthocyanidins: An update

52. Characteristics and Nutritional and Cardiovascular-Health Properties of Seaweeds

53. Characteristics of One Health surveillance systems: A systematic literature review

54. Characterization of casein and alpha lactalbumin of African elephant (Loxodonta africana) milk

55. Characterization of dextran-grafted hydrophobic charge-induction resins: Structural properties, protein adsorption and transport

56. Characterization of functional properties of Enterococcus faecium strains isolated from human gut

57. Characterization of human leukocyte-HUVEC adhesion: Effect of cell preparation methods

58. Characterization of hyaluronic acid specific hyaluronate lyase (HylP) from Streptococcus pyogenes

59. Characterization of the fundamental properties of the N-terminal truncation (Δ exon 1) variant of estrogen receptor α in the rat

60. Characterization of the neuraminidase of the H1N1/09 pandemic influenza virus

61. Cheeses as food matrixes for probiotics: In vitro and in vivo tests

62. Chemical profile, antiproliferative, antioxidant and enzyme inhibition activities of Ocimum basilicum L. and Pulicaria undulata (L.) C.A. Mey. grown in Sudan

63. Chimeric proteins constructed from bacteriophage T7 gp4 and a putative primase–helicase from Arabidopsis thaliana

64. Cinnamomum cassia essential oil and its major constituent cinnamaldehyde induced cell cycle arrest and apoptosis in human oral squamous cell carcinoma HSC‐3 cells

65. Clitoria ternatea L. petal bioactive compounds display antioxidant, antihemolytic and antihypertensive effects, inhibit α-amylase and α-glucosidase activities and reduce human LDL cholesterol and DNA induced oxidation

66. Comparability studies of new 3rd generation recombinant human factor VIII GreenGene F after improvement of formulation and viral inactivation/removal process

67. Comparative and bioinformatics analyses of pathogenic bacterial secretomes identified by mass spectrometry in Burkholderia species

68. Comparative functional characterization of canine IgG subclasses

69. Comparative studies on osmosis based encapsulation of sodium diclofenac in porcine and outdated human erythrocyte ghosts

70. Comparative studies on the heterogeneity of plasma-derived and recombinant human albumins in laboratory use

9. A functionally conserved member of the FTZâF1 nuclear receptor family from Schistosoma mansoni