U.S. flag

An official website of the United States government

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Https

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

PubAg

Main content area

You searched for: Subject licorice Remove constraint Subject: licorice Text availability Citation in PubAg Remove constraint Text availability: Citation in PubAg
Start Over

Search

769  Search Results

« Previous | 1 - 50 of 769 |
Number of results to display per page

Search Results

1. Unusual sweeteners of plant origin

Author:
Inglett, G.E.
Source:
Herbarist 1982 v.48 pp. 67-78
Subject:
artificial sweeteners; sugar substitutes; nonnutritive sweeteners; Glycyrrhiza glabra; licorice; Stevia rebaudiana; Dioscoreophyllum cumminsii; Thaumatococcus daniellii; Hydrangea macrophylla; Polypodium vulgare; plant characteristics; geographical distribution; sweetness; Synsepalum dulcificum
Handle:
10113/25299

2. Identification and quantification of isoflavonoid and triterpenoid compliance markers in a licorice-root extract powder

Author:
Weinberg, D.S.; Manier, M.L.; Richardson, M.D.; Haibach, F.G.
Source:
Journal of agricultural and food chemistry 1993 v.41 no.1 pp. 42-47
ISSN:
0021-8561
Subject:
licorice; roots; isoflavones; triterpenoids; diet study techniques; chemical constituents of plants; extracts
Abstract:
... Marker compounds are needed to determine dietary compliance in free-living human study populations participating in dietary intervention trials for cancer research. Two isoflavonoid and one triterpenoid marker compounds were detected and identified in a licorice-root extract powder. A convenient method that involves hydrolysis' solvent extraction, and liquid chromatographic analysis was developed ...
DOI:
10.1021/jf00025a009

3. Licorice ameliorates postural hypotension caused by diabetic autonomic neuropathy

Author:
Basso, A.; Paola, L.D.; Erle, G.; Boscaro, M.; Armanini, D.
Source:
Diabetes care 1994 v.17 no.11 pp. 1356
ISSN:
0149-5992
Subject:
diabetes; licorice; hypotension; nervous system diseases; blood glucose; women; case studies
DOI:
10.2337/diacare.17.11.1356
PubMed:
7821181

4. Protective effect of brocolli, onion, carrot, and licorice extracts against cytotoxicity of N-nitrosamines evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay

Author:
Martinez, A.; Cambero, I.; Ikken, Y.; Marin, M.L.; Haza, A.I.; Morales, P.
Source:
Journal of agricultural and food chemistry 1998 v.46 no.2 pp. 585-589
ISSN:
0021-8561
Subject:
nitrosopyrrolidine; N-nitrosodimethylamine; broccoli; Allium cepa; Glycyrrhiza glabra; Brassica oleracea var. italica; Daucus carota; plant extracts; medicinal properties; cytotoxicity; bioassays; onions; cell lines; licorice; carrots; cell proliferation
Abstract:
... The protective effect of nine fruit and vegetable aqueous (H2O) and ethanolic (EtOH) extracts against the cytotoxicity of N-nitrosodimethylamine (NDMA), N-nitrosopyrrolidine (NPYR), N-nitrosodibutylamine (NDBA), and N-nitrosopiperidine (NPIP) was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The fruit extracts under investigation did not show a protective e ...
DOI:
10.1021/jf970636i

5. The amino acids precursory to proteins are primary human food: proline, glutamine, and arginine found free in the juices of common vegetables and herbs

Author:
Kapuler, A.M.; Gurusiddiah, S.
Source:
Journal of medicinal food 1998 v.1 no.2 pp. 97-115
ISSN:
1096-620X
Subject:
chicory; Helianthus annuus; corolla; spatial distribution; bamboos; roots; soups; juices; proline; fenugreek; miso; cultivars; glutamine; arginine; cucumbers; chickpeas; licorice; free amino acids; glutamic acid
DOI:
10.1089/jmf.1998.1.97

6. Mutagenicity and cytotoxicity of fruits and vegetables evaluated by the Ames test and 3-(4,5-dimethylthiazol-2-yl)- 2,5-diphenyltetrazolium bromide (MTT) assay / Mutagenicidad y citotoxicidad de frutas y vegetales evaluadas por el test de Ames y el ensayo del bromuro de 3-(4,5-dimetiltiazol-2-il)-2,5-difeniltetrazolio (MTT)

Author:
A. Martínez; Y. Ikken; M.I. Cambero; M.L. Marín; A.I. Haza; C. Casas; P. Morales
Source:
Food science and technology international 1999 v.5 no.5 pp. 431-437
ISSN:
1082-0132
Subject:
Allium sativum; Ames test; Ananas comosus var. comosus; Brassica oleracea; Glycyrrhiza glabra; broccoli; carrots; cytotoxicity; ethanol; garlic; kiwifruit; licorice; mutagenicity; mutagens; pineapples
Abstract:
... The mutagenic and cytotoxic activity of the aqueous (H₂O) and ethanolic (EtOH) extracts of fruits and vegetables were studied by the Ames test and the MTT assay. A significant mutagenic activity was found for three H₂O extracts of broccoli (Brassica oleracea), carrot (Dacus carota) and licorice (Glycyrrhiza glabra) and for one EtOH extract of kiwi (Ananas sativus) of the nine species analyzed. The ...
DOI:
10.1177/108201329900500509

7. The herbal sling vs. the magic bullet

Author:
Duke, J.A.
Source:
Journal of medicinal food 1999 v.2 no.2 pp. 73-76
ISSN:
1096-620X
Subject:
biomedical research; Pueraria montana var. lobata; Aesculus hippocastanum; Silybum marianum; medicinal plants; Ginkgo biloba; cranberries; licorice; Echinacea purpurea; Serenoa repens; herbal medicines; ginger
DOI:
10.1089/jmf.1999.2.73
PubMed:
19281351

8. Isolation and identification of main constitutents in an enzymatically hydrolysed licorice extract sweetener

Author:
Liu, H.M.; Akiyama, T.; Sugimoto, N.; Maitani, T.
Source:
Food additives & contaminants 2001 v.18 no.4 pp. 281-284
ISSN:
0265-203X
Subject:
licorice; sweeteners; plant extracts; food safety; food additives; chemical composition
Abstract:
... Licorice extract including glycyrrhizin as the major component is used as a safe sweetener in many countries. Enzymatically hydrolysed licorice extract (EHLE) is also used as a sweetener in Japan. In the present paper, the constituents of EHLE were investigated as apart of the studies for evaluating its quality and safety as a food additive. Three oleanane-type monoglycosides along with glycyrrhiz ...
DOI:
10.1080/02652030116955

9. Licorice and cancer

Author:
Wang, Z.Y.; Nixon, D.W.
Source:
Nutrition and cancer 2001 v.39 no.1 pp. 1-11
ISSN:
0163-5581
Subject:
carcinogenesis; chemical composition; polyphenols; mechanism of action; polysaccharides; human health and safety; neoplasms; disease prevention; Glycyrrhiza glabra; mutagenesis; plant extracts; antineoplastic agents; triterpenoids; biomedical research; licorice; roots; pharmacokinetics
Abstract:
... Licorice root is one of the oldest and most frequently employed botanicals in Chinese medicine. In the United States, licorice products are most often used as flavoring and sweetening agents in food products. Constituents of licorice include triterpenoids, such as glycyrrhizin and its aglycone glycyrrhizic acid, various polyphenols, and polysaccharides. A number of pharmaceutical effects of licori ...
DOI:
10.1207/S15327914nc391_1
PubMed:
11588889

10. Effects of raw materials, ingredients, and production lines on arsenic and copper concentrations in confectionery products

Author:
Carbonell-Barrachina, A.A.; Garcia, E.; Sanchez Soriano, J.; Aracil, P.; Burlo, F.
Source:
Journal of agricultural and food chemistry 2002 v.50 no.13 pp. 3738-3742
ISSN:
0021-8561
Subject:
licorice; chewing gum; molasses; ingredients; arsenic; copper; food contamination; food processing; extracts
Abstract:
... The Spaniard legislation sets up maximum levels for total arsenic (As) and copper (Cu) in confectionery products at 0.1 and 5.0 microgram g-1, respectively. Concentrations of these two trace elements were determined in four confectionery products: chewing gum, two licorice items, and soft candy. The effects of raw materials quality and production lines were studied. Arsenic and copper were quantif ...
DOI:
10.1021/jf0115591
PubMed:
12059152

11. Glabrene and isoliquiritigenin as tyrosinase inhibitors from licorice roots

Author:
Nerya, O.; Vaya, J.; Musa, R.; Izrael, S.; Ben-Arie, R.; Tamir, S.
Source:
Journal of agricultural and food chemistry 2003 v.51 no.5 pp. 1201-1207
ISSN:
0021-8561
Subject:
monophenol monooxygenase; melanocytes; Glycyrrhiza glabra; isoflavans; medicinal plants; skin diseases; enzyme inhibitors; licorice; medicinal properties; enzyme activity; roots; herbal medicines
Abstract:
... Tyrosinase is known to be a key enzyme in melanin biosynthesis, involved in determining the color of mammalian skin and hair. Various dermatological disorders, such as melasama, age spots, and sites of actinic damage, arise from the accumulation of an excessive level of epidermal pigmentation. The inadequacy of current therapies to treat these conditions as well as high cytotoxicity and mutagenici ...
DOI:
10.1021/jf020935u
PubMed:
12590456

12. Induction of Apoptosis by Hydroxydibenzoylmethane through Coordinative Modulation of Cyclin D3, Bcl-XL, and Bax, Release of Cytochrome c, and Sequential Activation of Caspases in Human Colorectal Carcinoma Cells

Author:
Pan, Min-Hsiung; Huang, Mei-Chen; Wang, Ying-Jan; Lin, Jen-Kun; Lin, Chao-Hsien
Source:
Journal of agricultural and food chemistry 2003 v.51 no.14 pp. 3977-3984
ISSN:
0021-8561
Subject:
DNA; DNA fragmentation; antimutagenic activity; apoptosis; caspase-2; caspase-3; cell viability; colorectal neoplasms; cytochrome c; digestion; licorice
Abstract:
... DBM (dibenzoylmethane) is a minor constituent of licorice that has antimutagenic activity. However, its other biological activities are not well-known. The structurally related β-diketones hydroxydibenzoylmethane (HDB) and hydroxymethyldibenzoylmethane (HMDB) were able to induce apoptosis in colorectal carcinoma COLO 205 cells. Thus, the effect of structurally related β-diketones on cell viability ...
DOI:
10.1021/jf034094i

13. New dihydrostilbene derivatives from the leaves of Glycyrrhiza glabra and evaluation of their antioxidant activity

Author:
Biondi, D.M.; Rocco, C.; Ruberto, G.
Source:
Journal of natural products 2003 v.66 no.4 pp. 477-480
ISSN:
0163-3864
Subject:
sunflower oil; peroxides; linoleic acid; biosynthesis; stilbenes; phytochemicals; Glycyrrhiza glabra; medicinal plants; plant extracts; spectral analysis; oxidation; licorice; antioxidant activity; stereochemistry; chemical structure; leaves; Italy
DOI:
10.1021/np020365s
PubMed:
12713396

14. Source of Arsenic in Licorice Confectionery Products

Author:
Carbonell-Barrachina, Angel Antonio; Aracil, Pedro; Garcia, Elena; Burlo, Francisco; Martinez-Sanchez, Francisco
Source:
Journal of agricultural and food chemistry 2003 v.51 no.6 pp. 1749-1752
ISSN:
0021-8561
Subject:
Food and Drug Administration; arsenic; atomic absorption spectrometry; glycyrrhizin; high performance liquid chromatography; licorice; pearls; sweets; throat; United States
Abstract:
... Spanish legislation sets a maximum level for total arsenic (As) in confectionery products at 0.1 μg g-1. The U.S. Food and Drug Administration limitations for glycyrrhizic acid in hard and soft candies are 160 and 31 mg g-1, respectively. Arsenic and glycyrrhizic acid were determined in 22 different confectionery products: 9 throat pearls, 4 hard candies, and 9 soft candies. Arsenic and glycyrrhiz ...
DOI:
10.1021/jf026057h

15. The effect of gamma irradiation on the microbial load, mineral concentration and sensory characteristics of liquorice (Glycyrrhiza glabra L)

Author:
Al-Bachir, Mahfouz; Lahham, George
Source:
Journal of the science of food and agriculture 2003 v.83 no.1 pp. 70-75
ISSN:
0022-5142
Subject:
Glycyrrhiza glabra; calcium; cobalt; color; flavor; gamma radiation; glycyrrhizin; licorice; microbial load; mineral content; roots; sensory evaluation; sodium; taste; temperature; total dissolved solids; viscosity
Abstract:
... Ground liquorice roots were exposed to various doses (0, 5, 10, 15 and 20 kGy) of gamma radiation from a( 60)Co source. Irradiated and non-irradiated samples were stored at room temperature. Microbial population, viscosity, concentrations of some minerals and the sensory properties of the extracts were evaluated after 0 and 12 months of storage. Tests carried out immediately after irradiation show ...
DOI:
10.1002/jsfa.1276

16. Using Both Chemical and Biological Fingerprints for the Quality Study of Estrogenic Licorice (Glycyrrhiza uralensis)

Author:
Teng, S.C.; Tsai, H.J.; Tsai, M.C.; Lee, W.M.; Chen, I.C.; Lin, C.C.
Source:
Journal of food science 2003 v.68 no.7 pp. 2372-2377
ISSN:
0022-1147
Subject:
Glycyrrhiza uralensis; chromatography; estrogenic properties; ethanol; formononetin; humans; licorice; plasmids; reporter genes; screening; yeasts
Abstract:
... The quality of phytoestrogenic licorice was studied by using both chemical and biological fingerprints. A recombinant yeast strain that consists of an estrogen responsive element linked with a reporter gene (ADE2) and a transformed human estrogen receptor-containing plasmid was used for screening and evaluation of estrogenic activity in licorice. Several estrogen-like components in licorice were s ...
DOI:
10.1111/j.1365-2621.2003.tb05775.x

17. Memory-strengthening activity of Glycyrrhiza glabra in exteroceptive and interoceptive behavioral models

Author:
Parle, M.; Dhingra, D.; Kulkarni, S.K.
Source:
Journal of medicinal food 2004 v.7 no.4 pp. 462-466
ISSN:
1096-620X
Subject:
antimicrobial properties; memory; antidepressants; anti-inflammatory activity; rats; conditioned behavior; Alzheimer disease; Glycyrrhiza glabra; medicinal plants; plant extracts; antioxidant activity; rhizomes; licorice; mental health; roots; anti-ulcer activity; cognition; expectorants
DOI:
10.1089/jmf.2004.7.462
PubMed:
15671690

18. Modulations of the Bcl-2/Bax family were involved in the chemopreventive effects of licorice root (Glycyrrhiza uralensis Fisch) in MCF-7 human breast cancer cell

Author:
Jo, E.H.; Hong, H.D.; Ahn, N.C.; Jung, J.W.; Yang, S.R.; Park, J.S.; Kim, S.H.; Lee, Y.S.; Kang, K.S.
Source:
Journal of agricultural and food chemistry 2004 v.52 no.6 pp. 1715-1719
ISSN:
0021-8561
Subject:
human diseases; anticarcinogenic activity; chemoprevention; plant extracts; medicinal plants; proteolysis; apoptosis; regulatory proteins; nucleotidyltransferases; NAD ADP-ribosyltransferase; licorice; cell lines; cell proliferation; roots; breast neoplasms; Glycyrrhiza uralensis
Abstract:
... Recently, cancer chemoprevention with strategies using foods and medicinal herbs has been regarded as one of the most visible fields for cancer control. Genistein in soy, American ginseng, and resveratrol are well-known to have antiproliferative properties in human breast cancer. Licorice root is a botanical, a shrub native to southern Europe and Asia, which primarily has desirable qualities in sw ...
DOI:
10.1021/jf035012t

19. An on-membrane quantitative analysis system for glycyrrhizin in licorice roots and traditional Chinese medicines

Author:
Osamu Morinaga; Ayako Fujino; Hiroyuki Tanaka; Yukihiro Shoyama
Source:
Analytical and bioanalytical chemistry 2005 v.383 no.4 pp. 668-672
ISSN:
1618-2642
Subject:
Oriental traditional medicine; acetonitrile; bovine serum albumin; computer software; formic acid; glycyrrhizin; licorice; monoclonal antibodies; peroxidase; quantitative analysis; roots
Abstract:
... An on-membrane quantitative analysis system has been developed for determining glycyrrhizin (GC) in licorice roots and traditional Chinese medicines. A GC standard and the extracts of licorice roots and traditional Chinese medicines were applied to a polyethersulfone (PES) membrane and were developed by acetonitrile/water/formic acid (45:55:2, by volume), then treated with a NaIO₄ solution followe ...
DOI:
10.1007/s00216-005-0054-1
PubMed:
16158295

20. Efficient production of (2S)-flavanones by Escherichia coli containing an artificial biosynthetic gene cluster

Author:
Ikuo Miyahisa; Masafumi Kaneko; Nobutaka Funa; Hisashi Kawasaki; Hiroyuki Kojima; Yasuo Ohnishi; Sueharu Horinouchi
Source:
Applied microbiology and biotechnology 2005 v.68 no.4 pp. 498-504
ISSN:
0175-7598
Subject:
Corynebacterium glutamicum; Escherichia coli; Pueraria; Streptomyces coelicolor; acetyl-CoA carboxylase; bacteria; chalcone isomerase; genes; licorice; naringenin; naringenin-chalcone synthase; phenylalanine; phenylalanine ammonia-lyase; plasmids; tyrosine; yeasts
Abstract:
... For the fermentative production of plant-specific flavanones (naringenin, pinocembrin) by Escherichia coli, a plasmid was constructed which carried an artificial biosynthetic gene cluster, including PAL encoding a phenylalanine ammonia-lyase from a yeast, ScCCL encoding a cinnamate/coumarate:CoA ligase from the actinomycete Streptomyces coelicolor A3(2), CHS encoding a chalcone synthase from a lic ...
DOI:
10.1007/s00253-005-1916-3
PubMed:
15770480

21. Isolation and identification of flavonoids in licorice and a study of their inhibitory effects on tyrosinase

Author:
Fu, B.; Li, H.; Wang, X.; Lee, F.S.C.; Cui, S.
Source:
Journal of agricultural and food chemistry 2005 v.53 no.19 pp. 7408-7414
ISSN:
0021-8561
Subject:
monophenol monooxygenase; enzyme inhibitors; flavonoids; licorice; enzyme inhibition; food preservatives; Glycyrrhiza uralensis
Abstract:
... Five different flavonoids were isolated from licorice after multistep chromatographic fractionation. The aim was to identify and characterize active components in licorice responsible for antibrowning activities and to seek new tyrosinase inhibitors for applications as antibrowning and depigmenting agents in the food and cosmetic industries. The isolated flavonoids were identified as liquiritin, l ...
DOI:
10.1021/jf051258h

22. The effect of gamma irradiation and grinding on the microbial load of dried licorice roots (Glycyrrhiza glabra L.), and quality characteristics of their extract

Author:
M. Al-Bachir; R. Zeinou
Source:
Acta alimentaria 2005 v.34 no.3 pp. 287-294
ISSN:
0139-3006
Subject:
Glycyrrhiza glabra; bacteria; calcium; cobalt; electrical conductivity; gamma radiation; glycyrrhizin; grinding; ions; irradiation; licorice; microbial load; pH; particle size; roots
Abstract:
... Ground roots of licorice with 3 particle sizes (fine particles <0.35 mm, medium: 0.35-8.0 mm, and coarse particles ?8.0 mm diameter) were exposed to 5, 10, 15 and 20 kGy of gamma radiation from a 60Co source. Microbial population of ground roots and the characteristics of their extracts (concentrations of glycyrrhizinic acid, total and inorganic dissolved solids), mineral ions (Ca+ ...
DOI:
10.1556/AAlim.34.2005.3.11

23. The effect of gamma irradiation and grinding on the microbial load of dried licorice roots (Glycyrrhiza glabra L.), and quality characteristics of their extract

Author:
M. Al-Bachir; R. Zeinou
Source:
Acta alimentaria 2005 v.34 no.3 pp. 287-294
ISSN:
1588-2535
Subject:
Glycyrrhiza glabra; gamma radiation; glycyrrhizin; irradiation; licorice; microbial load; pH
Abstract:
... Ground roots of licorice with 3 particle sizes (fine particles <0.35 mm, medium: 0.35-8.0 mm, and coarse particles ?8.0 mm diameter) were exposed to 5, 10, 15 and 20 kGy of gamma radiation from a ⁶⁰Co source. Microbial population of ground roots and the characteristics of their extracts (concentrations of glycyrrhizinic acid, total and inorganic dissolved solids), mineral ions (Ca⁺⁺ and K⁺), pH an ...
DOI:
10.1556/aalim.34.2005.3.11

24. The use of rheology to characterize flow behavior of liquorice solutions

Author:
Gabriele, D.; Curcio, S.; Migliori, M.; De Cindio, B.
Source:
Journal of food process engineering 2005 v.27 no.6 pp. 464-475
ISSN:
0145-8876
Subject:
viscoelasticity; shear strength; aqueous solutions; Glycyrrhiza glabra; plant extracts; flow; gels; friction; confectionery industry; licorice; temperature; roots
DOI:
10.1111/j.1745-4530.2004.00397.x

25. Tissue Culture and Micropropagation of Mongolian Licorice (Glycyrrhiza uralensis Fisch.)

Author:
Yu. Oyunbileg; Kh. Altanzul; Ts. Oyunsuren; D. Bayarlkhagva
Source:
Mongolian journal of biological sciences 2005 v.3 no.1 pp. 21-24
ISSN:
2225-4994
Subject:
Glycyrrhiza uralensis; cotyledons; flavonoids; licorice; micropropagation; saponins; tissue culture
Abstract:
... Mongolian licorice (Glycyrrhiza uralensis Fisch.) is a pharmacologically important plant rich in flavonoids and saponins. For tissue culture, root and cotyledon explants from seedlings were used. Sterilized explants with one node were used for micropropagation. Half-strength Murasige-Skuge medium and Gamborg‘s B5 medium with different supplements were used for the induction of calluses and multipl ...
DOI:
10.22353/mjbs.2005.03.03

26. Comparative brain cholinesterase-inhibiting activity of Glycyrrhiza glabra, Myristica fragrans, ascorbic acid, and metrifonate in mice

Author:
Dhingra, D.; Parle, M.; Kulkarni, S.K.
Source:
Journal of medicinal food 2006 v.9 no.2 pp. 281-283
ISSN:
1096-620X
Subject:
mice; animal models; cholinesterase; enzyme inhibitors; enzyme inhibition; plant extracts; licorice; brain; nutmeg; ascorbic acid; acetylcholine; biochemical pathways
DOI:
10.1089/jmf.2006.9.281
PubMed:
16822217

27. Effect of salt and drought stress on antioxidant enzymes activities and SOD isoenzymes of liquorice (Glycyrrhiza uralensis Fisch)

Author:
Pan, Yan; Wu, Li Jun; Yu, Zeng Liang
Source:
Plant growth regulation 2006 v.49 no.2-3 pp. 157-165
ISSN:
0167-6903
Subject:
Glycyrrhiza uralensis; antioxidants; drought; enzyme activity; isozymes; licorice; lipid peroxidation; oxidative stress; peroxidase; salinity; salt stress; salts; seedlings; superoxide dismutase; water stress
Abstract:
... The effects of salinity and drought on the antioxidative system (SOD, POD, CAT) were studied in liquorice seedlings (Glycyrrhiza uralensis Fisch). The results showed that both salt and drought stresses could induce oxidative stress, as indicated by the increase level of lipid peroxidation. The activities of SOD and POD were up-regulated by salt and drought stress, while CAT activity decreased. An ...
DOI:
10.1007/s10725-006-9101-y

28. Isoliquiritigenin induces apoptosis by depolarizing mitochondrial membranes in prostate cancer cells

Author:
Jung, J.I.; Lim, S.S.; Choi, H.J.; Cho, H.J.; Shin, H.K.; Kim, E.J.; Chung, W.Y.; Park, K.K.; Park, J.H.Y.
Source:
Journal of nutritional biochemistry 2006 v.17 no.10 pp. 689-696
ISSN:
0955-2863
Subject:
chalcone; phenolic compounds; chemical constituents of plants; licorice; Glycyrrhiza glabra; shallots; Allium cepa; bean sprouts; chemoprevention; apoptosis; anticarcinogenic activity; cell culture; prostatic neoplasms; cell lines; mitochondria; cell proliferation; cell cycle; cytochrome c; nutritional intervention
Abstract:
... Isoliquiritigenin (ISL), a simple chalcone derivative, 4,2',4'-trihydroxychalcone, found in licorice, shallot and bean sprouts, has been reported to have chemoprotective effects. To examine the effects of ISL on the growth of prostate cancer cells, we cultured MAT-LyLu (MLL) rat and DU145 human prostate cancer cells with various concentrations (0-20 micromole/L) of ISL. Treatment of the cells with ...
DOI:
10.1016/j.jnutbio.2005.11.006
PubMed:
16517140

29. Rapid clonal propagation of licorice(Glycyrrhiza Glabra) byin vitro shoot culture

Author:
Nagat Mousa; P. Siaguru; S. Wiryowidagdo; M. E. Wagih
Source:
Sugar tech 2006 v.8 no.4 pp. 292-298
ISSN:
0972-1525
Subject:
Glycyrrhiza glabra; beverages; explants; glycyrrhizin; licorice; naphthaleneacetic acid; pharmaceutical industry; plantlets; pruning; rhizomes; roots; stolons; sweets; vegetative propagation
Abstract:
... Methods and conditions for rapid and efficient clonal propagation of a selected clonal line (L58) of licorice,Glycyrrhiza glabra, were developed includingin vitro shoot culture and nursery pruning. An efficient pruning regime of 3-months-old greenhouse-grown plants enhanced auxiliary shoot formation, and significantly increased primary shoot culture (PSC) explant harvest by over 50%. Cloning L58in ...
DOI:
10.1007/BF02943571

30. 2-Hydroxyisoflavanone Dehydratase is a Critical Determinant of Isoflavone Productivity in Hairy Root Cultures of Lotus japonicus

Author:
Shimamura, Masayuki; Akashi, Tomoyoshi; Sakurai, Nozomu; Suzuki, Hideyuki; Saito, Kazuki; Shibata, Daisuke; Ayabe, Shin-ichi; Aoki, Toshio
Source:
Plant & cell physiology 2007 v.48 no.11 pp. 1652-1657
ISSN:
0032-0781
Subject:
Lotus corniculatus var. japonicus; biosynthesis; complementary DNA; coumestrol; daidzein; enzymes; genistein; genotype; licorice; roots; soybeans
Abstract:
... Hairy root cultures of a model legume, Lotus japonicus, were established to characterize two heterologous cDNAs encoding enzymes involved in isoflavone biosynthesis, i.e. licorice 2-hydroxyisoflavanone synthase (IFS) and soybean 2-hydroxyisoflavanone dehydratase (HID) catalyzing sequential reactions to yield isoflavones. While the control and the IFS overexpressor did not accumulate detectable iso ...
DOI:
10.1093/pcp/pcm125
PubMed:
17921150

31. Anti-oxidant Constituents of the Roots and Stolons of Licorice (Glycyrrhiza glabra)

Author:
Chin, Y.W.; Jung, H.A.; Liu, Y.; Su, B.N.; Castoro, J.A.; Keller, W.J.; Pereira, M.A.; Kinghorn, A.D.
Source:
Journal of agricultural and food chemistry 2007 v.55 no.12 pp. 4691-4697
ISSN:
0021-8561
Subject:
chemical composition; human diseases; chemical constituents of plants; lung neoplasms; Glycyrrhiza glabra; stolons; chemoprevention; colorectal neoplasms; chalcone; human nutrition; mice; antineoplastic agents; lignans; animal models; licorice; antioxidant activity; roots; antioxidants
Abstract:
... As part of a search for new cancer chemopreventive agents, a new chalcone derivative (1), a novel group of neolignan lipid esters (2), and seven known phenolic compounds (formononetin, glabridin, hemileiocarpin, hispaglabridin B, isoliquiritigenin, 4'-O-methylglabridin, and paratocarpin B) (3-9) were isolated from the roots and stolons of licorice (Glycyrrhiza glabra). The structures of compound 1 ...
DOI:
10.1021/jf0703553

32. Clinical Safety of Licorice Flavonoid Oil (LFO) and Pharmacokinetics of Glabridin in Healthy Humans

Author:
Aoki, Fumiki; Nakagawa, Kaku; Kitano, Mitsuaki; Ikematsu, Hideyuki; Nakamura, Kenjirou; Yokota, Shinichi; Tominaga, Yuji; Arai, Naoki; Mae, Tatsumasa
Source:
Journal of the American College of Nutrition 2007 v.26 no.3 pp. 209-218
ISSN:
0731-5724
Subject:
men; medium chain triacylglycerols; humans; pharmacokinetics; blood chemistry; women; glycemic effect; dosage; abdominal fat; flavonoids; licorice; antioxidant activity; clinical trials; adverse effects; dietary supplements
Abstract:
... OBJECTIVE: Licorice flavonoids have various physiological activities such as abdominal fat-lowering, hypoglycemic and antioxidant effects. Licorice flavonoid oil (LFO: Kaneka Glavonoid Rich OilTM) is a new dietary ingredient containing licorice flavonoids dissolved in medium-chain triglycerides (MCT). Glabridin is one of the bioactive flavonoids included specifically in licorice Glycyrrhiza glabra ...
DOI:
10.1080/07315724.2007.10719603
PubMed:
17634165

33. Detection of estrogenic activity in herbal teas by in vitro reporter assays

Author:
Kohno, Hirao; Kouda, Katsuyasu; Tokunaga, Rikio; Sonoda, Yoshiaki
Source:
European food research & technology 2007 v.225 no.5-6 pp. 913-920
ISSN:
1438-2377
Subject:
Mentha piperita nothosubsp. piperita; beverages; estrogen receptors; estrogenic properties; food research; herbal tea; humans; ingredients; licorice; menopause; plant estrogens; safety assessment; yeasts
Abstract:
... Herbal teas have become popular as alternatives to caffeinated beverages during past two decades. However, toxicological studies of herbal teas have been limited and the safety of herbal teas thus remains unknown. We focused on the estrogenic activities of herbal teas since some of their ingredients are similar to those used in herbal remedies for menopause relief and therefore contain phytoestrog ...
DOI:
10.1007/s00217-006-0506-7

34. Determination of glycyrrhizin in liqueurs by on-line coupled capillary isotachophoresis with capillary zone electrophoresis

Author:
Kvasnička, F.; Voldřich, M.; Vyhnálek, J.
Source:
Journal of chromatography 2007 v.1169 no.1-2 pp. 239-242
ISSN:
0021-9673
Subject:
glycyrrhizin; food composition; food analysis; liqueurs; licorice; capillary zone electrophoresis
DOI:
10.1016/j.chroma.2007.08.074

35. Effects of arbuscular mycorrhizal fungi on the growth, nutrient uptake and glycyrrhizin production of licorice (Glycyrrhiza uralensis Fisch)

Author:
Liu, Jingnan; Wu, Lijun; Wei, Shenglin; Xiao, Xiang; Su, Caixin; Jiang, Peng; Song, Zhongbang; Wang, Tao; Yu, Zengliang
Source:
Plant growth regulation 2007 v.52 no.1 pp. 29-39
ISSN:
0167-6903
Subject:
Glomus mosseae; Glycyrrhiza uralensis; developmental stages; glycyrrhizin; leaves; licorice; mycorrhizal fungi; nutrient uptake; phosphorus; plant growth; root systems; roots; sand; shoots; vesicular arbuscular mycorrhizae
Abstract:
... The growth of licorice in arid areas faces nutritional and environmental stresses. Arbuscular mycorrhizal (AM) fungi have been shown to increase the abilities of plants to develop. However, little is known regarding the role of AM fungi in licorice (Glycyrrhiza uralensis) growth. In the present study, by inoculation with two AM fungi, Glomus mosseae (Nicolson & Gerdemann) Gerd. & Trappe and Glomus ...
DOI:
10.1007/s10725-007-9174-2

36. Establishment of regenerative callus and cell suspension system of licorice (Glycyrrhiza glabra) for the production of the sweetener glycyrrhizinin vitro

Author:
Nagat A. Mousa; P. Siaguru; S. Wiryowidagdo; M. E. Wagih
Source:
Sugar tech 2007 v.9 no.1 pp. 72-82
ISSN:
0972-1525
Subject:
2,4-D; Glycyrrhiza glabra; callus; cell suspension culture; cell viability; economic productivity; genetic engineering; genotype; glycyrrhizin; growth regulators; hematocrit; kinetin; licorice; liquids; metabolism; morphogenesis; phenolic compounds; plantlets; secondary metabolites; sucrose
Abstract:
... Regenerative callus and cell suspension of licorice,Glycyrrhiza glabra, is a prerequisite to the possible production of the non-nutritive sweetener “Glycyrrhizin” in cell suspension. The primary embryogenic callus (PEC), initiated from young leaflets of four-weeks-oldin vitro-grown plantlets regenerated by shoot culture, was developed on modified Gamborg’s B5 medium supplemented with 2,4-D, Kineti ...
DOI:
10.1007/BF02956917

37. Evaluation and selection of elite clonal genotypes of the sweet crop licorice (Glycyrrhiza glabra) in a new environment

Author:
Nagat A. Mousa; P. Siaguru; S. Wiryowidagdo; M. E. Wagih
Source:
Sugar tech 2007 v.9 no.1 pp. 83-94
ISSN:
0972-1525
Subject:
Glycyrrhiza glabra; biomass; bulk density; chlorophyll; drought tolerance; enzyme activity; genotype; greenhouses; licorice; peroxidase; photosynthesis; rain; rootstocks; seed germination; seeds; selection index; stomata; subtropics; vigor; Papua New Guinea
Abstract:
... The adaptability and vigour of exotic licorice,Glycyrrhiza glabra, as a source of sugar substitute in the subtropics of Papua New Guinea (PNG) was monitored from seed germination to 3-month in the greenhouse and to 12-month in the field. The germination potential of sulphuric acid-scarified seeds was significantly (p>0.01) higher than un-scarified. A total of 120 early-germinated seeds were select ...
DOI:
10.1007/BF02956918

38. High levels of ochratoxin A in licorice and derived products

Author:
Arino, A.; Herrera, M.; Estopanan, G.; Juan, T.
Source:
International journal of food microbiology 2007 v.114 no.3 pp. 366-369
ISSN:
0168-1605
Subject:
sweets; toxigenic strains; immunoaffinity chromatography; GRAS substances; Glycyrrhiza glabra; food contamination; plant extracts; food pathogens; microbial detection; reversed-phase high performance liquid chromatography; licorice; ochratoxin A; roots
Abstract:
... The ochratoxin A (OTA) content of 30 samples of licorice root and derived products (licorice-confectionery, licorice block, and licorice extract) was analyzed by a standard HPLC-fluorescence technique and confirmed by methyl-ester formation. All analyzed samples of licorice and derived products were found to contain ochratoxin A, and some of them showed extremely high concentrations up to 252.8 ng ...
DOI:
10.1016/j.ijfoodmicro.2006.08.005

39. Immuno-enhancement effects of Huang Qi Liu Yi Tang in a murine model of cyclophosphamide-induced leucopenia

Author:
Huang, G.C.; Wu, L.S.; Chen, L.G.; Yang, L.L.; Wang, C.C.
Source:
Journal of ethnopharmacology 2007 v.109 no.2 pp. 229-235
ISSN:
0378-8741
Subject:
Ziziphus; Astragalus; Hedysarum; Glycyrrhiza glabra; licorice; medicinal plants; roots; chemical constituents of plants; isoflavonoids; plant extracts; medicinal properties; bioassays; mice; immune system; Oriental traditional medicine; herbal medicines; ethnobotany; China; Taiwan
Abstract:
... Tonic Chinese prescriptions are widely used in daily foods to improve health in Taiwan. Huang Qi Liu Yi Tang (HQLYT) is one such tonic Chinese prescription. In this study, the immuno-enhancement effects of HQLYT tonic were explored using an in vitro splenocyte proliferation assay and by evaluating improvements in cyclophosphamide-induced leucopenia in a BaLb/c mice model. HQLYT is composed of Radi ...
DOI:
10.1016/j.jep.2006.07.023

40. Molecular characterization of the GmAMS1 gene encoding β-amyrin synthase in soybean plants

Author:
Chung, E.; Cho, Ch. -W.; Kim, K. -Y.; Chung, J.; Kim, J. -I.; Chung, Y. -S.; Fukui, K.; Lee, J. -H.
Source:
Russian journal of plant physiology 2007 v.54 no.4 pp. 518-523
ISSN:
1021-4437
Subject:
RNA; complementary DNA; elicitors; fluorescence in situ hybridization; genes; licorice; methyl jasmonate; seedlings; soybeans; suppression subtractive hybridization; temperature; ultraviolet radiation
Abstract:
... Suppression subtractive hybridization was used to isolate wound-induced cDNAs from soybean plants. One of wound-induced cDNA, gmwi33 designated GmAMS1, showed a high homology with genes encoding β-amyrin synthase. GmAMS1 protein showed 89% identity with licorice GgbAS1. In five-day-old dark-grown seedlings, RNA expression of GmAMS1 was strongly induced by light, weakly induced by methyl jasmonate ...
DOI:
10.1134/S1021443707040139

41. Near-infrared spectroscopy for classification of licorice (Glycyrrhizia uralensis Fisch) and prediction of the glycyrrhizic acid (GA) content

Author:
Wang, L.; Lee, F.S.C.; Wang, X.R.
Source:
Lebensmittel-Wissenschaft + Technologie 2007 v.40 no.1 pp. 83-88
ISSN:
0023-6438
Subject:
chemical composition; product authenticity; glycyrrhizin; essential oils; medicinal plants; plant extracts; near-infrared spectroscopy; least squares; standards of identity; food composition; licorice; food additives; herbal medicines; Glycyrrhiza uralensis
DOI:
10.1016/j.lwt.2005.08.011

42. Note. Speciation of Arsenic in Licorice Confectionery Products and Estimation of Health Risks

Author:
A. Signes; F. Burló; T. Casinos; A. A. Carbonell-Barrachina
Source:
Food science and technology international 2007 v.13 no.1 pp. 41-47
ISSN:
1082-0132
Subject:
acceptable daily intake; arsenic; laws and regulations; licorice; pearls; risk estimate; sweets; throat; toxicity; Spain
Abstract:
... Total-arsenic (T-As) and arsenic (As) species were determined by HPLC-HG-AAS in ten different confectionery products: nine throat pearls and an industrial licorice extract. The Spanish legislation sets a maximum total-As content in confectionery products at 0.1mg/g. T-As concentrations were above the permitted maximum limit (mean of 0.219±0.008mg/g). All As was present in the form of toxic inorgan ...
DOI:
10.1177/1082013207075655

43. Ochratoxin A in liquorice as affected by processing methods

Author:
Arino, A.; Herrera, M.; Langa, E.; Raso, J.; Herrera, A.
Source:
Food additives & contaminants 2007 v.24 no.9 pp. 987-992
ISSN:
0265-203X
Subject:
peeling; food contamination; Glycyrrhiza glabra; plant extracts; high performance liquid chromatography; heat treatment; food processing; washing; licorice; ochratoxin A; specialty crops; roots; herbal medicines
Abstract:
... A study of the effect of several processing methods on the concentration of ochratoxin A (OTA) in liquorice and derived products was carried out. The effect of the sorting, washing and peeling of fresh liquorice roots was investigated; as well as the production at a laboratory scale of liquorice extract and block liquorice from dry roots. Finally, the thermal stability of OTA was assessed. The OTA ...
DOI:
10.1080/02652030701317277
PubMed:
17691012

44. Separation of Liquiritin by simulated moving bed chromatography

Author:
Cong, J.; Lin, B.
Source:
Journal of chromatography 2007 v.1145 no.1-2 pp. 190-194
ISSN:
0021-9673
Subject:
Glycyrrhiza glabra; licorice; medicinal plants; separation; chromatography; extraction; aromatic compounds
DOI:
10.1016/j.chroma.2007.01.088

45. Suppression by Licorice Flavonoids of Abdominal Fat Accumulation and Body Weight Gain in High-Fat Diet-Induced Obese C57BL/6J Mice

Author:
Fumiki AOKI; Shinichi HONDA; Hideyuki KISHIDA; Mitsuaki KITANO; Naoki ARAI; Hozumi TANAKA; Shinichi YOKOTA; Kaku NAKAGAWA; Tomiko ASAKURA; Yuji NAKAI; Tatsumasa MAE
Source:
Bioscience, biotechnology, and biochemistry 2007 v.71 no.1 pp. 206-214
ISSN:
1347-6947
Subject:
DNA microarrays; abdominal fat; adipocytes; beta oxidation; biotechnology; body weight changes; ethanol; fatty acids; flavonoids; gene expression; hepatocytes; high fat diet; histology; hydrophobicity; licorice; liver; obesity; oils
Abstract:
... We applied licorice flavonoid oil (LFO) to high-fat diet-induced obese C57BL/6J mice and investigated its effect. LFO contains hydrophobic flavonoids obtained from licorice by extraction with ethanol. The oil is a mixture of medium-chain triglycerides, having glabridin, a major flavonoid of licorice, concentrated to 1.2% (w/w). Obese mice were fed on a high-fat diet containing LFO at 0 (control), ...
DOI:
10.1271/bbb.60463

46. 90-Day repeated-dose toxicity study of licorice flavonoid oil (LFO) in rats

Author:
Nakagawa, K.; Kitano, M.; Kishida, H.; Hidaka, T.; Nabae, K.; Kawabe, M.; Hosoe, K.
Source:
Food and chemical toxicology 2008 v.46 no.7 pp. 2349-2357
ISSN:
0278-6915
Subject:
Glycyrrhiza glabra; licorice; plant fats and oils; flavonoids; rats; animal models; human nutrition; subchronic toxicity; gender differences; males; females; food safety; dose response; no observed adverse effect level; anticoagulant activity
DOI:
10.1016/j.fct.2008.03.015
PubMed:
18448224

47. A time course analysis of systemic administration of aqueous licorice extract on spatial memory retention in rats

Author:
Sharifzadeh, M.; Shamsa, F.; Shiran, S.; Karimfar, M.H.; Miri, A.H.; Jalalizadeh, H.; Gholizadeh, S.; Salar, F.; Tabrizian, K.
Source:
Planta medica 2008 v.74 no.5 pp. 485-490
ISSN:
0032-0943
Subject:
Glycyrrhiza glabra; licorice; medicinal plants; traditional medicine; plant extracts; glycyrrhizin; memory; rats; animal models
DOI:
10.1055/s-2008-1074494
PubMed:
18404595

48. Antimicrobial potential of Glycyrrhiza glabra roots

Author:
Gupta, Vivek K.; Fatima, Atiya; Faridi, Uzma; Negi, Arvind S.; Shanker, Karuna; Kumar, J.K.; Rahuja, Neha; Luqman, Suaib; Sisodia, Brijesh S.; Saikia, Dharmendra; Darokar, M.P.; Khanuja, Suman P.S.
Source:
Journal of ethnopharmacology 2008 v.116 no.2 pp. 377-380
ISSN:
0378-8741
Subject:
Glycyrrhiza glabra; licorice; roots; medicinal plants; antimicrobial properties; fractionation; bioassays; Mycobacterium tuberculosis; in vitro studies; Gram-positive bacteria; Gram-negative bacteria
Abstract:
... The present study was aimed to investigate antimicrobial potential of Glycyrrhiza glabra roots. Antimycobacterial activity of Glycyrrhiza glabra was found at 500μg/mL concentration. Bioactivity guided phytochemical analysis identified glabridin as potentially active against both Mycobacterium tuberculosis H₃₇Ra and H₃₇Rv strains at 29.16μg/mL concentration. It exhibited antimicrobial activity agai ...
DOI:
10.1016/j.jep.2007.11.037
PubMed:
18182260

49. Antioxidant activity of traditional Chinese medicinal herbs

Author:
Lee, Y.C.; Chuah, A.M.; Yamaguchi, T.; Takamura, H.; Matoba, T.
Source:
Food science and technology research 2008 v.14 no.2 pp. 205-210
ISSN:
1344-6606
Subject:
tocopherols; Cassia; Chrysanthemum; free radicals; medicinal plants; phenolic compounds; herbal medicines; free radical scavengers; pharmacology; Poria; ascorbic acid; licorice; antioxidant activity; spices; roots; Oriental traditional medicine; Hibiscus; China
DOI:
10.3136/fstr.14.205

50. Antioxidant and anti-inflammatory activities of water distillate and its dichloromethane extract from licorice root (Glycyrrhiza uralensis) and chemical composition of dichloromethane extract

Author:
Tanaka, Aki; Horiuchi, Masahiro; Umano, Katsummi; Shibamoto, Takayuki
Source:
Journal of the science of food and agriculture 2008 v.88 no.7 pp. 1158-1165
ISSN:
0022-5142
Subject:
Glycyrrhiza uralensis; licorice; medicinal plants; roots; plant extracts; antioxidant activity; anti-inflammatory activity; antioxidants; chemical composition
Abstract:
... BACKGROUND:Licorice root is one of the most widely used medicinal herbs and its medicinal properties, such as antibacterial, anti-ulcer, anti-tumorigenic and anti-atherosclerotic activities, have been widely reported. However, there are only a few reports on basic chemical and biological studies of the water distilled components of licorice root.RESULTS:Chinese licorice root was water distilled an ...
DOI:
10.1002/jsfa.3191