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1. 18 β-glycyrrhetinic acid inhibits rotavirus replication in culture

Author:
Michele E Hardy; Jay M Hendricks; Jeana M Paulson; Nicholas R Faunce
Source:
Virology journal 2012 v.9 no.1 pp. 96
ISSN:
1743-422X
Subject:
Rotavirus; adsorption; antiviral properties; cell culture; epithelial cells; glycyrrhizin; immunomodulators; licorice; mechanism of action; medicinal properties; metabolites; vaccines; viral proteins; viruses
Abstract:
... BACKGROUND: Glycyrrhizin (GA) and primary metabolite 18β-glycyrrhetinic acid (GRA) are pharmacologically active components of the medicinal licorice root, and both have been shown to have antiviral and immunomodulatory properties. Although these properties are well established, the mechanisms of action are not completely understood. In this study, GA and GRA were tested for the ability to inhibit ...
DOI:
10.1186/1743-422X-9-96

2. 18β-Glycyrrhetinic acid inhibits adipogenic differentiation and stimulates lipolysis

Author:
Myung-Hee Moon; Jae-Kyo Jeong; You-Jin Lee; Jae-Won Seol; Dong-Choon Ahn; In-Shik Kim; Sang-Youel Park
Source:
Biochemical and biophysical research communications 2012 v.420 no.4 pp. 805-810
ISSN:
0006-291X
Subject:
Western blotting; adipocytes; adipogenesis; adiponectin; anti-inflammatory activity; antibacterial properties; enzymes; gene expression regulation; glycerol; insulin; licorice; lipolysis; messenger RNA; mice; models; obesity; phosphorylation; reverse transcriptase polymerase chain reaction; serine; transcription (genetics); transcription factors
Abstract:
... 18β-Glycyrrhetinic acid (18β-GA) obtained from the herb liquorice has various pharmacological properties including anti-inflammatory and anti-bacterial activities. However, potential biological anti-obesity activities are unclear. In this study, novel biological activities of 18β-GA in the adipogenesis of 3T3-L1 preadipocytes and in lipolysis of differentiated adipocytes were identified. Mouse 3T3 ...
DOI:
10.1016/j.bbrc.2012.03.078

3. 18β-Glycyrrhetinic acid potently inhibits Kv1.3 potassium channels and T cell activation in human Jurkat T cells

Author:
Xiao-Xing Fu; Li-Li Du; Ning Zhao; Qian Dong; Yu-Hua Liao; Yi-Mei Du
Source:
Journal of ethnopharmacology 2013 v.148 no.2 pp. 647-654
ISSN:
0378-8741
Subject:
T-lymphocytes; Western blotting; calcium; enzyme-linked immunosorbent assay; gene expression; humans; immunomodulation; inhibitory concentration 50; interleukin-2; licorice; patch-clamp technique; potassium channels; quantitative polymerase chain reaction; secretion; traditional medicine
Abstract:
... ETHNOPHARMACOLOGICAL RELEVANCE: Licorice has been extensively used in traditional medicines for treatment of many diseases, including inflammations and immunological disorders. Recent studies have shown that the anti-inflammatory and immunomodulation activities of licorice have been attributed to its active component, glycyrretinic acid (GA). GA consists of two isoforms, 18α- and 18β-. However, it ...
DOI:
10.1016/j.jep.2013.05.022
PubMed:
23707333

4. 18β-glycyrrhetinic acid inhibits migration and invasion of human gastric cancer cells via the ROS/PKC-α/ERK pathway

Author:
Hongke Cai; Xi Chen; Jianbo Zhang; Jijian Wang
Source:
Natural medicines 2018 v.72 no.1 pp. 252-259
ISSN:
1340-3443
Subject:
antineoplastic activity; bioactive compounds; cadherins; chemoprevention; dose response; humans; licorice; metastasis; mitogen-activated protein kinase; neoplasm cells; phosphorylation; protein kinase C; signal transduction; stomach neoplasms; vimentin
Abstract:
... 18β-glycyrrhetinic acid (18β-GA) is a bioactive component of licorice root which exerts pharmacological activities including anti-inflammatory, antiviral, anti-oxidative and anti-cancer effects. The current study further investigated the molecular mechanisms associated with the inhibitory effects of 18β-GA on tumor metastasis in human gastric cancer cells. The results indicated that 18β-GA signifi ...
DOI:
10.1007/s11418-017-1145-y

5. 18β‐glycyrrhetinic acid attenuates anandamide‐induced adiposity and high‐fat diet induced obesity

Author:
Miyoung Park; Ji‐Hae Lee; Jin Kyu Choi; Yong Deog Hong; Il‐Hong Bae; Kyung‐Min Lim; Young‐Ho Park; Hunjoo Ha
Source:
Molecular nutrition & food research 2014 v.58 no.7 pp. 1436-1446
ISSN:
1613-4125
Subject:
active ingredients; adipocytes; adiposity; agonists; animal models; blood lipids; diet; fatty-acid synthase; gene expression regulation; genes; hyperlipidemia; licorice; mitogen-activated protein kinase; obesity; phosphorylation
Abstract:
... SCOPE: Previous reports suggest that licorice extract has various metabolically beneficial effects and may help to alleviate adiposity and hyperlipidemia. However, underlying anti‐obesity mechanisms still remain elusive. Moreover, it is unknown which single ingredient in licorice extract would mediate such effects. We aimed to demonstrate that licorice extract and its active ingredients can inhibi ...
DOI:
10.1002/mnfr.201300763
PubMed:
24687644

6. 18β‐glycyrrhetinic acid improves high‐intensity exercise performance by promoting glucose‐dependent energy production and inhibiting oxidative stress in mice

Author:
Xuan Ma; Hui Chen; Lixing Cao; Shuang Zhao; Chong Zhao; Shutao Yin; Hongbo Hu
Source:
Phytotherapy research 2021 v.35 no.12 pp. 6932-6943
ISSN:
0951-418X
Subject:
Western blotting; athletic performance; bioactive compounds; energy; energy metabolism; enzyme-linked immunosorbent assay; exercise; exercise test; fluorescent antibody technique; glucose transporters; glycogen; insulin; licorice; liver; muscles; oxidative stress; phytotherapy; reactive oxygen species; research
Abstract:
... It has been shown that 18β‐glycyrrhetinic acid (18β‐GA), the main bioactive compound of licorice, can modulate oxidative stress and metabolic processes in liver and skin. Given the critical role of oxidative stress and energy metabolism in exercise‐induced fatigue, we hypothesized that 18β‐GA could exert an ergogenic action by inhibiting excess reactive oxygen species (ROS) induction and promoting ...
DOI:
10.1002/ptr.7310

7. 195 Effect of feeding a licorice extract to Japanese Black cows on embryo production performance after superovulation treatment

Author:
Y. Aoyagi; M. Takeuchi; Y. Oono; M. Urakawa; M. Koiwa
Source:
Reproduction, fertility, and development 2019 v.31 no.1 pp. 222
ISSN:
1031-3613
Subject:
Wagyu; artificial insemination; calving; cows; embryo (animal); estrus; follicle-stimulating hormone; glycyrrhizin; guidelines; licorice; liver; ova; prostaglandins; superovulation; swine; t-test; ultrasonography
Abstract:
... The objective was to determine the effect of feeding a licorice extract that contains glycyrrhizic acid, which is known to have a liver function-enhancing effect, on embryo production performance after superovulation treatment in Japanese Black cows. Japanese Black breed cows (n=136) that had calved 1 to 4 times and had normal uteri as seen by ultrasonography after at least 40 days from the last c ...
DOI:
10.1071/RDv31n1Ab195

8. 2-Hydroxyisoflavanone Dehydratase is a Critical Determinant of Isoflavone Productivity in Hairy Root Cultures of Lotus japonicus

Author:
Shimamura, Masayuki; Akashi, Tomoyoshi; Sakurai, Nozomu; Suzuki, Hideyuki; Saito, Kazuki; Shibata, Daisuke; Ayabe, Shin-ichi; Aoki, Toshio
Source:
Plant & cell physiology 2007 v.48 no.11 pp. 1652-1657
ISSN:
0032-0781
Subject:
Lotus corniculatus var. japonicus; biosynthesis; complementary DNA; coumestrol; daidzein; enzymes; genistein; genotype; licorice; roots; soybeans
Abstract:
... Hairy root cultures of a model legume, Lotus japonicus, were established to characterize two heterologous cDNAs encoding enzymes involved in isoflavone biosynthesis, i.e. licorice 2-hydroxyisoflavanone synthase (IFS) and soybean 2-hydroxyisoflavanone dehydratase (HID) catalyzing sequential reactions to yield isoflavones. While the control and the IFS overexpressor did not accumulate detectable iso ...
DOI:
10.1093/pcp/pcm125
PubMed:
17921150

9. 4-Hydroxyderricin and xanthoangelol isolated from Angelica keiskei prevent dexamethasone-induced muscle loss

Author:
Yasukiyo Yoshioka; Yumi Samukawa; Yoko Yamashita; Hitoshi Ashida
Source:
Food & function 2020 v.11 no.6 pp. 5498-5512
ISSN:
2042-650X
Subject:
Angelica keiskei; antagonists; chalcones; dexamethasone; glucocorticoid receptors; licorice; males; mass movement; mice; mortality; muscle tissues; muscles; muscular atrophy; myotubes; phosphorylation; protein degradation; quality of life; risk; ubiquitin-protein ligase
Abstract:
... Since a decrease in muscle mass leads to an increased risk of mortality, the prevention of muscle wasting contributes to maintaining the quality of life. Recently, we reported that glabridin, a prenylated flavonoid in licorice, prevents dexamethasone-induced muscle loss. In this study, we focused on the other prenylated chalcones 4-hydroxyderricin and xanthoangelol in Ashitaba (Angelica keiskei) a ...
DOI:
10.1039/d0fo00720j

10. 90-Day repeated-dose toxicity study of licorice flavonoid oil (LFO) in rats

Author:
Nakagawa, K.; Kitano, M.; Kishida, H.; Hidaka, T.; Nabae, K.; Kawabe, M.; Hosoe, K.
Source:
Food and chemical toxicology 2008 v.46 no.7 pp. 2349-2357
ISSN:
0278-6915
Subject:
Glycyrrhiza glabra; licorice; plant fats and oils; flavonoids; rats; animal models; human nutrition; subchronic toxicity; gender differences; males; females; food safety; dose response; no observed adverse effect level; anticoagulant activity
DOI:
10.1016/j.fct.2008.03.015
PubMed:
18448224

11. AMF enhance secondary metabolite production in ashwagandha, licorice, and marigold in a fungi-host specific manner

Author:
Leena Johny; David M. Cahill; Alok Adholeya
Source:
Rhizosphere 2021 v.17 pp. 100314
ISSN:
2452-2198
Subject:
Acaulospora; Claroideoglomus claroideum; Claroideoglomus etunicatum; Glomus hoi; Glycyrrhiza glabra; Rhizophagus irregularis; Tagetes erecta; Withania somnifera; alpha-terthienyl; biosynthesis; crops; glycyrrhizin; host plants; knowledge; licorice; methodology; mycorrhizal fungi; rhizosphere; roots; secondary metabolites; symbiosis
Abstract:
... Strategies to enhance the production of secondary metabolites, derived from medicinal and agriculturally important plants have been the subject of exploration to enable effective utilization of these biorepositories. Through symbiosis, arbuscular mycorrhizal fungi (AMF), modify plant primary and secondary metabolite biosynthesis. The relationship thus offers the opportunity to exploit combinations ...
DOI:
10.1016/j.rhisph.2021.100314

12. AMPK activation by liquiritigenin inhibited oxidative hepatic injury and mitochondrial dysfunction induced by nutrition deprivation as mediated with induction of farnesoid X receptor

Author:
Eun Hye Jung; Ju-Hee Lee; Sang Chan Kim; Young Woo Kim
Source:
European journal of nutrition 2017 v.56 no.2 pp. 635-647
ISSN:
1436-6207
Subject:
AMP-activated protein kinase; NAD ADP-ribosyltransferase; apoptosis; blood serum; cell viability; flavonoids; flow cytometry; gene expression; glutathione; hepatocytes; human cell lines; licorice; ligands; liver; messenger RNA; metformin; mice; mitochondria; oxidative stress; phosphorylation; proteins; starvation
Abstract:
... PURPOSE: Nutrition is indispensable for cell survival and proliferation. Thus, loss of nutrition caused by serum starvation in cells could induce formation of reactive oxygen species (ROS), resulting in cell death. Liquiritigenin (LQ) is an active flavonoid in licorice and plays a role in the liver as a hepatic protectant. METHODS: This study investigated the effect of LQ, metformin [an activator ...
DOI:
10.1007/s00394-015-1107-7

13. Administration of isoliquiritigenin prevents nonalcoholic fatty liver disease through a novel IQGAP2‐CREB‐SIRT1 axis

Author:
Li Zhang; Sheng‐Ye Yang; Feng‐Rong Qi‐Li; Xiao‐Xiao Liu; Wei‐Tao Zhang; Chao Peng; Ping Wu; Ping Li; Pingping Li; Xiaojun Xu
Source:
Phytotherapy research 2021 v.35 no.7 pp. 3898-3915
ISSN:
0951-418X
Subject:
fatty liver; flavonoids; heart; homeostasis; humans; licorice; lipid metabolism; lipid peroxidation; lipids; liver; mass spectrometry; phosphorylation; phosphotransferases (kinases); phytotherapy; proteolysis; proteome; research
Abstract:
... Isoliquiritigenin (ISO) is a flavonoid extracted from the root of licorice, which serves various biological and pharmacological functions including antiinflammatory, antioxidation, liver protection, and heart protection. However, the mechanism of its action remains elusive and the direct target proteins of ISO have not been identified so far. Through cell‐based screening, we identified ISO as a po ...
DOI:
10.1002/ptr.7101

14. Adsorption and self-assembly properties of the plant based biosurfactant, Glycyrrhizic acid

Author:
I.M. Tucker; A. Burley; R.E. Petkova; S.L. Hosking; J. Penfold; R.K. Thomas; P.X. Li; J.R.P. Webster; R. Welbourn; J. Doutch
Source:
Journal of colloid and interface science 2021 v.598 pp. 444-454
ISSN:
0021-9797
Subject:
adsorption; anisotropy; aqueous solutions; biosurfactants; gelation; gels; glycyrrhizin; ingredients; isotropy; licorice; liquid-air interface; micelles; neutron diffraction; neutrons; sorption isotherms; texture; triterpenoid saponins
Abstract:
... There is an increased interest in the use of natural surfactant as replacements for synthetic surfactants due to their biosustainable and biocompatible properties. A category of natural surfactants which are attracting much current interest is the triterpenoid saponins; surface active components found extensively in a wide range of plant species. A wide range of different saponin structures exist, ...
DOI:
10.1016/j.jcis.2021.03.101

15. Advanced trends in controlling Helicobacter pylori infections using functional and therapeutically supplements in baby milk

Author:
Gamal M. Hamad; Tarek H. Taha; Nehal M. El-Deeb; Ali M. A. Alshehri
Source:
Journal of food science and technology 2015 v.52 no.12 pp. 8156-8163
ISSN:
0022-1155
Subject:
Helicobacter pylori; adults; alkaloids; alternative medicine; amino acids; antibacterial properties; antibiotic resistance; antibiotics; bacteria; children; cloves; cumin; flavonoids; gastritis; ginger; humans; infants; licorice; milk; pathogens; pepper; plant extracts; pomegranates; proteins; proton pump inhibitors; reducing sugars; sage; saponins; stomach neoplasms; stomach ulcers; tannins; terpenoids
Abstract:
... Helicobacter pylori is a common human pathogen infecting about 30 % of children and 60 % of adults worldwide. It is responsible for diseases such as gastritis, peptic ulcer and gastric cancer. H. pylori treatment based on antibiotics with proton pump inhibitor, but therapy failure is shown to be higher than 20 % and is essentially due to an increasing in prevalence of antibiotic-resistant bacteria ...
DOI:
10.1007/s13197-015-1875-3
PubMed:
26604389
PubMed Central:
PMC4648882

16. Aggregate formation of glycyrrhizic acid

Author:
Keisuke Matsuoka; Ryusuke Miyajima; Yudai Ishida; Seigo Karasawa; Tomokazu Yoshimura
Source:
Colloids and surfaces 2016 v.500 pp. 112-117
ISSN:
0927-7757
Subject:
X-radiation; acidity; aqueous solutions; biosurfactants; carboxylic acids; fluorescent dyes; glucuronic acid; glycyrrhizin; hydrophilicity; hydrophobicity; licorice; light scattering; micelles; pH; solubility; solvents; surface tension; transmission electron microscopy
Abstract:
... Glycyrrhizic acid is derived from the licorice root. The compound is amphiphilic with a large hydrophobic aglycone group, and two glucuronic acids and a carboxyl group constituting the hydrophilic part. Therefore, glycyrrhizic acid can form aggregates or lower the surface tension of aqueous solutions owing to its specific amphiphilic structure. The aqueous solubility of glycyrrhizic acid is relati ...
DOI:
10.1016/j.colsurfa.2016.04.032

17. Agro-economical selection of the best horticultural practices for reducing drought damages of rainfed fig cultivar 'Sabz'

Author:
E. Zare; H. Zare
Source:
Acta horticulturae 2017 no.1173 pp. 389-394
ISSN:
0567-7572
Subject:
Ficus carica; color; cultivars; drought; evapotranspiration; figs; horticulture; horticulturists; licorice; mulches; orchards; ripening; soil water; surveys; tree damage; trees; vegetation; water stress
Abstract:
... Agricultural drought is a temporary condition that occurs for a short period of time due to deficient precipitation on vegetation and prolonged deficiency of soil moisture. This is the result of imbalance between soil moisture and evapotranspiration. The effectiveness of horticultural practices in conserving of soil moisture and reducing of evapotranspiration area has generally been found to be hi ...
DOI:
10.17660/ActaHortic.2017.1173.67

18. Aim for production of Glycyrrhizae Radix in Japan (3): development of a new licorice cultivar

Author:
Kazuo Ozaki; Makio Shibano
Source:
Natural medicines 2014 v.68 no.2 pp. 358-362
ISSN:
1340-3443
Subject:
aerial parts; crossing; cultivars; flavonoids; glycyrrhizin; licorice; underground parts; Japan
Abstract:
... The development of cultivars is indispensable for the establishment of a method aimed at producing licorice in Japan. The cultivar should have the following attributes: (1) the underground parts should grow vigorously; (2) the glycyrrhizin (GL) content must be 2.5 % or greater; and (3) the architecture of the aerial parts should be erect. A new cultivar suitable for the domestic production of lico ...
DOI:
10.1007/s11418-013-0807-7
PubMed:
24293363

19. Alleviation of lung injury by glycyrrhizic acid in benzo(a)pyrene exposed rats: Probable role of soluble epoxide hydrolase and thioredoxin reductase

Author:
Wajhul Qamar; Rehan Khan; Abdul Quaiyoom Khan; Muneeb U Rehman; Abdul Lateef; Mir Tahir; Farrah Ali; Sarwat Sultana
Source:
Toxicology 2012 v.291 no.1-3 pp. 25-31
ISSN:
0300-483X
Subject:
Glycyrrhiza glabra; alkaline phosphatase; benzo(a)pyrene; caspases; catalase; cell viability; cytokines; elastase; epithelium; epoxide hydrolase; glycyrrhizin; hydrogen peroxide; lactate dehydrogenase; licorice; lungs; neutrophils; oral administration; phospholipids; physiology; protective effect; rats; toxicology; transcription factor NF-kappa B
Abstract:
... Benzo(a)pyrene [B(a)P] is known to alter lung physiology by interfering in various intracellular pathways including alterations in NF-κB activities, cytokine release and cell survival. NF-κB suppression/activation plays a major role in cell survival status. Present investigation deals with such kind of effects of B(a)P on lungs in relation with soluble epoxide hydrolase (sEH) and thioredoxin reduc ...
DOI:
10.1016/j.tox.2011.10.012

20. Alleviation of salt stress and changes in glycyrrhizin accumulation by arbuscular mycorrhiza in liquorice (Glycyrrhiza glabra) grown under salinity stress

Author:
Setareh Amanifar; Maryam Khodabandeloo; Ehsan Mohseni Fard; Mohammad Sadegh Askari; Mohsen Ashrafi
Source:
Environmental and experimental botany 2019 v.160 pp. 25-34
ISSN:
0098-8472
Subject:
Glycyrrhiza glabra; biosynthesis; electrolytes; gene expression; genes; glycyrrhizin; host plants; licorice; medicine; mycorrhizal fungi; nutrition; plant growth; plant tissues; proline; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; roots; saline soils; salinity; salt stress; secondary metabolites; shoots; sodium; squalene; vesicular arbuscular mycorrhizae
Abstract:
... The symbiotically interaction of arbuscular mycorrhiza (AM) with liquorice (Glycyrrhiza glabra) which is widely used in traditional Iranian medicine, may have a good potential to enhance host plant growth and resistance to salt stress and may regulate the synthesis and accumulation pattern of secondary metabolites in plant tissues. The aims of this study were to assess the effect of AM fungus Funn ...
DOI:
10.1016/j.envexpbot.2019.01.001

21. Alleviative effect of licorice on copper chloride-induced oxidative stress in the brain: biochemical, histopathological, immunohistochemical, and genotoxic study

Author:
Heba El-Sayed Mostafa; Eman Ahmad Alaa-Eldin; Dalia Abdallah El-Shafei; Nehal S. Abouhashem
Source:
Environmental science and pollution research international 2017 v.24 no.22 pp. 18585-18595
ISSN:
0944-1344
Subject:
DNA damage; adults; antioxidant activity; antioxidants; apoptosis; astrocytes; brain; chlorides; comet assay; copper; cytoplasm; enzyme activity; glutathione; histopathology; immunohistochemistry; licorice; males; malondialdehyde; mutagens; neurons; neurotoxicity; oxidative stress; protective effect; rats; tissues; traditional medicine
Abstract:
... Although copper is an essential micronutrient involved in a variety of biological processes indispensable for sustaining life, it can be toxic when administered in excess. Licorice (Glycyrrhizaglabra) has been used in Chinese folk medicine for the treatment of various disorders. Licorice has the biological capabilities of detoxication, antioxidation, and antiinfection. Here, we test the hypothesis ...
DOI:
10.1007/s11356-017-9503-6

22. Amorfrutins Are Natural PPARγ Agonists with Potent Anti-inflammatory Properties

Author:
Fuhr Luise; Rousseau Morten; Plauth Annabell; Schroeder Frank C.; Sauer Sascha
Source:
Journal of natural products 2015 v.78 no.5 pp. 1160-1164
ISSN:
1520-6025
Subject:
Amorpha fruticosa; Glycyrrhiza; agonists; anti-inflammatory activity; benzoic acid; colon; indigo; inflammation; licorice; secretion
Abstract:
... Amorfrutins are isoprenoid-substituted benzoic acid derivatives, which were found in Amorpha fruticosa L. (bastard indigo) and in Glycyrrhiza foetida Desf. (licorice). Recently, amorfrutins were shown to be selective activators of the nuclear receptor PPARγ. Here, we investigated the effects and PPARγ-based mechanisms of reducing inflammation in colon cells by treatment with amorfrutins. In TNF-α- ...
DOI:
10.1021/np500747y

23. Analysis and occurrence of matrine in liquorice raw materials - Exclusion of its application as pesticide

Author:
Julia Schultz; Marion Raters; Maximilian Wittig; Birgit Christall; Frank Heckel
Source:
Food additives & contaminants 2022 v.39 no.2 pp. 351-361
ISSN:
1944-0057
Subject:
Sophora; ingredients; licorice; pesticides; raw materials; sweets
Abstract:
... A quick and selective analytical method was developed employing LC-MS/MS for the quantitation of matrine. This is known to be a natural ingredient of Sophora ssp. and is suggested to be a potential contaminant, e.g. in herbal raw materials from liquorice or confectionery products based on liquorice. To prove that the finding of matrine in liquorice roots does not originate from an active use of pe ...
DOI:
10.1080/19440049.2021.2005261

24. Analysis of Wear Characteristics of Blade Materials and Glycyrrhiza uralensis

Author:
Yameng Shi; Baoqin Wen; Liqiao Li; Tao Wang; Yang Li; Sixue Ren; Jingbin Li
Source:
Transactions of the ASABE v.64 no.4 pp. 1259-1268
ISSN:
2151-0032
Subject:
Glycyrrhiza uralensis; X-radiation; acid hydrolysis; atomic absorption spectrometry; cork; energy; forage grasses; friction; hydrochloric acid; licorice; oxidation; pyrolysis; spring; steel; surface roughness; thermal stability; thermogravimetry; titration; total Kjeldahl nitrogen; total mixed rations; wood; zero gravity
Abstract:
... HighlightsThe thermal reaction between Glycyrrhiza uralensis and metal was analyzed via thermogravimetry.The wear characteristics of three common blade metals were studied under laboratory conditions.The wear mechanisms on the blades by different parts of Glycyrrhiza uralensis were analyzed.Thermal oxidation and element transfer occurred during the wear of Glycyrrhiza uralensis and metals.Abstract ...
DOI:
10.13031/trans.14442

25. Analysis of herb–herb interaction when decocting together by using ultra-high-performance liquid chromatography–tandem mass spectrometry and fuzzy chemical identification strategy with poly-proportion design

Author:
Juan Shen; Xuan Mo; Yuping Tang; Li Zhang; Hanqing Pang; Yefei Qian; Yanyan Chen; Weiwei Tao; Sheng Guo; Erxin Shang; Shaoqing Zhu; Yunhe Ding; Jianming Guo; Pei Liu; Shulan Su; Dawei Qian; Jin-ao Duan
Source:
Journal of chromatography 2013 v.1297 no. pp. 168-178
ISSN:
0021-9673
Subject:
chemical composition; chemical structure; databases; diterpenoids; ions; licorice; phenylpropanoids; quantitative analysis; tandem mass spectrometry; triterpenoid saponins; ultra-performance liquid chromatography
Abstract:
... A novel and generally applicable approach was established for the herb–herb interaction analysis when decocting together by using ultra-high-performance liquid chromatography coupled with a triple quadrupole electrospray tandem mass spectrometer and fuzzy chemical identification with poly-proportion design. A simple programme was originally developed for the rapid identification and classification ...
DOI:
10.1016/j.chroma.2013.05.001

26. Analysis of influences of spaceflight on chemical constituents in licorice by HPLC–ESI-MS/MS

Author:
Jing-Ze Zhang; Wen-Yuan Gao; Ying Gao; Dai-Lin Liu; Lu-Qi Huang
Source:
Acta physiologiae plantarum 2011 v.33 no.6 pp. 2511-2520
ISSN:
0137-5881
Subject:
triterpenoid saponins; plant breeding; seeds; licorice; space flight; ionization; glycyrrhizin; biochemical polymorphism; flavonoids; high performance liquid chromatography; secondary metabolites; coumarin; breeding methods; mass spectrometry; roots; satellites; Glycyrrhiza uralensis
Abstract:
... Focusing on the variations of chemical constituents in licorice root, influences of exposure to physical factors of spaceflight on licorice (Glycyrrhiza uralensis Fisch.) seeds were investigated. Licorice seeds obtained from two different producing areas were flown on a recoverable satellite for 18 days. After returning to earth, the seeds carried by the satellite and the parallel ground control w ...
DOI:
10.1007/s11738-011-0796-7

27. Analysis of international competitiveness of the China's licorice industry from the perspective of global trade

Author:
Zhi-Bin Yu; Shu-Heng Dong; Jia-Wei Zhang; De-Yun Li; Yan Liu; Hui Li; Shu-Shan Du
Source:
Journal of ethnopharmacology 2022 v.298 pp. 115613
ISSN:
0378-8741
Subject:
databases; exports; food industry; imports; international trade; licorice; market competition; market share; pharmaceutical industry; prices; raw materials; sustainable development; traditional medicine; value added; world markets; China; France; Germany; Iran; Kazakhstan; Uzbekistan
Abstract:
... Licorice is a multi-purpose plant raw material, which is widely used in the pharmaceutical industry and food industry, cosmetic industry, etc. It has a wide application in various countries and regions around the world. This paper studied the trade situation of licorice-related products among major countries and regions in the world, providing a practical reference for the sustainable development ...
DOI:
10.1016/j.jep.2022.115613

28. Analysis of the synergistic effect of glycyrrhizin and other constituents in licorice extract on lipopolysaccharide-induced nitric oxide production using knock-out extract

Author:
Takuhiro Uto; Osamu Morinaga; Hiroyuki Tanaka; Yukihiro Shoyama
Source:
Biochemical and biophysical research communications 2012 v.417 no.1 pp. 473-478
ISSN:
0006-291X
Subject:
Oriental traditional medicine; glycyrrhizin; inducible nitric oxide synthase; ingredients; licorice; lipopolysaccharides; macrophages; medicinal plants; mice; monoclonal antibodies; nitric oxide; plant extracts; synergism
Abstract:
... The pharmacological evidence for synergism between natural compounds is not fully elucidated. In this study, we investigated the synergistic function of one target compound in medicinal plant extract by using knock-out (KO) extract, which is one target compound-eliminated extract from whole crude extract. Licorice is the most important ingredient used in the traditional Chinese medicine (TCM) and ...
DOI:
10.1016/j.bbrc.2011.11.143

29. Analytical strategy to reveal the in vivo process of multi-component herbal medicine: A pharmacokinetic study of licorice using liquid chromatography coupled with triple quadrupole mass spectrometry

Author:
Xue Qiao; Min Ye; Cheng Xiang; Qing Wang; Chun-fang Liu; Wen-juan Miao; De-an Guo
Source:
Journal of chromatography 2012 v.1258 no. pp. 84-93
ISSN:
0021-9673
Subject:
Glycyrrhiza uralensis; bioavailability; chalcone; coumarin; glycyrrhizin; herbal medicines; isoflavones; licorice; liquid chromatography; mass spectrometry; metabolites; models; monitoring; pharmacokinetics; rats; saponins; toxicity
Abstract:
... Although various techniques have been employed to analyze drug metabolites, the metabolism of multi-component herbal medicine has seldom been fully addressed. In contrast to chemical drugs, a number of compounds in herbal medicine could get into circulation and then be metabolized. Moreover, these compounds may have metabolic interactions which make their pharmacokinetics (PK) even more complicate ...
DOI:
10.1016/j.chroma.2012.08.041

30. Anti-inflammatory activity of novel ammonium glycyrrhizinate/niosomes delivery system: Human and murine models

Author:
Carlotta Marianecci; Federica Rinaldi; Marica Mastriota; Stefano Pieretti; Elena Trapasso; Donatella Paolino; Maria Carafa
Source:
Journal of controlled release 2012 v.164 no.1 pp. 17-25
ISSN:
0168-3659
Subject:
adrenal cortex hormones; animal models; anti-inflammatory activity; anti-inflammatory agents; cellulose; cholesterol; cytotoxicity; eczema; erythema; humans; inflammation; licorice; mice; niosomes; psoriasis; surfactants; zeta potential
Abstract:
... Today there is a very great deal of interest among members of the global natural products community in investigating new plant constituents. Recent studies demonstrate that liquorice extracts are useful in the treatment of dermatitis, eczema, and psoriasis, with an efficacy comparable to that of corticosteroids. In this work, niosomes made up of surfactants (Tween 85 and Span 20) and cholesterol a ...
DOI:
10.1016/j.jconrel.2012.09.018

31. Anti-obesity effects of glabridin-rich supercritical carbon dioxide extract of licorice in high-fat-fed obese mice

Author:
Jiyun Ahn; Hyunjung Lee; Jayoung Jang; Suna Kim; Taeyoul Ha
Source:
Food and chemical toxicology 2013 v.51 pp. 439-445
ISSN:
0278-6915
Subject:
Glycyrrhiza glabra; adipocytes; adipogenesis; animal disease models; beta oxidation; binding proteins; carbon dioxide; carnitine palmitoyltransferase; dose response; fatty liver; gluconeogenesis; glucose; high fat diet; hypertrophy; licorice; liver; medicinal plants; mice; obesity; toxicology; transcription factors; weight gain; white adipose tissue
Abstract:
... Licorice (Glycyrrhiza glabra Linne) is a well-known medicinal plant and glabridin is an isoflavan isolated from licorice. In this study, we investigated the anti-obesity effect of glabridin and glabridin-rich supercritical fluid extract of licorice (LSC). Glabridin effectively inhibited adipogenesis in 3T3-L1 cells. Moreover, LSC showed inhibitory effect on adipogenesis in a dose-dependent manner. ...
DOI:
10.1016/j.fct.2012.08.048

32. Anti-oxidant Constituents of the Roots and Stolons of Licorice (Glycyrrhiza glabra)

Author:
Chin, Y.W.; Jung, H.A.; Liu, Y.; Su, B.N.; Castoro, J.A.; Keller, W.J.; Pereira, M.A.; Kinghorn, A.D.
Source:
Journal of agricultural and food chemistry 2007 v.55 no.12 pp. 4691-4697
ISSN:
0021-8561
Subject:
chemical composition; human diseases; chemical constituents of plants; lung neoplasms; Glycyrrhiza glabra; stolons; chemoprevention; colorectal neoplasms; chalcone; human nutrition; mice; antineoplastic agents; lignans; animal models; licorice; antioxidant activity; roots; antioxidants
Abstract:
... As part of a search for new cancer chemopreventive agents, a new chalcone derivative (1), a novel group of neolignan lipid esters (2), and seven known phenolic compounds (formononetin, glabridin, hemileiocarpin, hispaglabridin B, isoliquiritigenin, 4'-O-methylglabridin, and paratocarpin B) (3-9) were isolated from the roots and stolons of licorice (Glycyrrhiza glabra). The structures of compound 1 ...
DOI:
10.1021/jf0703553

33. Anti-oxidative effects of some dietary supplements on Yellow perch (Perca flavescens) exposed to different physical stressors

Author:
Hiam Elabd; Han-Ping Wang; Adel Shaheen; Hong Yao; Amany Abbass
Source:
Aquaculture reports 2017 v.8 pp. 21-30
ISSN:
2352-5134
Subject:
Astragalus membranaceus; Glycyrrhiza glabra; Perca flavescens; antioxidant activity; dietary supplements; fish; gene expression regulation; heat; histology; histopathology; hypoxia; licorice; liver
Abstract:
... In current study, Yellow perch (P. flavescens) was exposed to common forms of physical stressors and antioxidative effects of dietary incorporated Astragalus membranaceus (AM) and Glycyrrhiza glabra (liquorice) were assessed. To address this, for a four-week five groups of fish (31±1.0g, average weight) received 1, 2, and 3% (w/w) Glycyrrhiza glabra; and 1% G. glabra- A. membranaceus mixture daily ...
DOI:
10.1016/j.aqrep.2017.09.002
CHORUS:
10.1016/j.aqrep.2017.09.002
Chorus Open Access:
10.1016/j.aqrep.2017.09.002

34. Anti-pseudo-allergic components in licorice extract inhibit mast cell degranulation and calcium influx

Author:
Lu WANG; Gui-Zhou HU; Yin LU; Shu-Jun JIANG; Jin QI; Hua SU
Source:
Chinese journal of natural medicines 2022 v.20 no.6 pp. 421-431
ISSN:
1875-5364
Subject:
calcium; chalcone; glycyrrhizin; histamine; humans; leukemia; licorice; ligands; mast cells; mice; rats
Abstract:
... Pseudo-allergic reactions (PARs) widely occur upon application of drugs or functional foods. Anti-pseudo-allergic ingredients from natural products have attracted much attention. This study aimed to investigate anti-pseudo-allergic compounds in licorice. The anti-pseudo-allergic effect of licorice extract was evaluated in rat basophilic leukemia 2H3 (RBL-2H3) cells. Anti-pseudo-allergic compounds ...
DOI:
10.1016/S1875-5364(22)60148-1

35. Anti-rotaviral effects of Glycyrrhiza uralensis extract in piglets with rotavirus diarrhea

Author:
Mia Madel Alfajaro; Hyun-Jeong Kim; Jun-Gyu Park; Eun-Hye Ryu; Ji-Yun Kim; Young-Ju Jeong; Deok-Song Kim; Myra Hosmillo; Kyu-Yeol Son; Ju-Hwan Lee; Hyung-Jun Kwon; Young Bae Ryu; Su-Jin Park; Sang-Ik Park; Woo Song Lee; Kyoung-Oh Cho
Source:
Virology journal 2012 v.9 no.1 pp. 310
ISSN:
1743-422X
Subject:
Glycyrrhiza uralensis; Rotavirus; adverse effects; animal diseases; animal viruses; anti-inflammatory activity; antiviral agents; antiviral properties; diarrhea; drug therapy; enteritis; gastroenteritis; gene expression; herbal medicines; histology; humans; interferon-beta; interferon-gamma; interleukin-10; interleukin-8; licorice; messenger RNA; mitogen-activated protein kinase; piglets; plant extracts; small intestine; spleen; transcription factor NF-kappa B; tumor necrosis factor-alpha; viral shedding; viruses
Abstract:
... BACKGROUND: Since rotavirus is one of the leading pathogens that cause severe gastroenteritis and represents a serious threat to human and animal health, researchers have been searching for cheap, safe, and effective anti-rotaviral drugs. There is a widespread of interest in using natural products as antiviral agents, and among them, licorice derived from Glycyrrhiza spp. has exerted antiviral pro ...
DOI:
10.1186/1743-422X-9-310

36. Antiatherosclerotic effects of licorice extract supplementation on hypercholesterolemic patients: decreased CIMT, reduced plasma lipid levels, and decreased blood pressure

Author:
Yacov Fogelman; Diana Gaitini; Eli Carmeli
Source:
Food & nutrition research 2016 v.60 no.1 pp. 30830
ISSN:
1654-661X
Subject:
atherosclerosis; blood lipids; blood plasma; diastolic blood pressure; high density lipoprotein; humans; hypercholesterolemia; licorice; low density lipoprotein cholesterol; mice; oxidation; patients; systolic blood pressure
Abstract:
... Ethanolic extract of licorice root has been shown to reduce low-density lipoprotein (LDL) oxidation in atherosclerotic mice and in both hypercholesterolemic and normal lipidemic humans. This study examined the effect of licorice-root extract on carotid intima-media thickness (CIMT) in individuals with hypercholesterolemia. Individuals with hypercholesterolemia (total cholesterol ≥6.18 mmol/L [240 ...
DOI:
10.3402/fnr.v60.30830

37. Antibacterial and Antiadhesive Activities of Extracts from Edible Plants against Soft Drink Spoilage by Asaia spp.

Author:
Hubert Antolak; Agata Czyzowska; Dorota Kregiel
Source:
Journal of food protection 2017 v.80 no.1 pp. 25-34
ISSN:
0362-028X
Subject:
Asaia bogorensis; Camellia sinensis; Cinnamomum verum; Glycyrrhiza; Sambucus nigra; Urtica dioica; adenosine triphosphate; adhesion; bacteria; bacterial adhesion; bark; catechin; chemical composition; cinnamon; culture media; elderberries; ethanol; flavanones; flowers; food plants; glycosides; green tea; high performance liquid chromatography; kaempferol; leaves; licorice; mass spectrometry; mineral water; phenolic acids; plankton; plant extracts; plate count; polystyrenes; quercetin; soft drinks; spoilage; viability
Abstract:
... This study was conducted to investigate the antibacterial and antiadhesive activities of ethanol extracts from five edible plant parts: cinnamon bark (Cinnamomum zeylanicum), licorice root (Glycyrrhiza radix), nettle leaves (Urtica dioica), green tea leaves (Camellia sinensis), and elderberry flowers (Sambucus nigra). The chemical constituents of the extracts were identified using high-performance ...
DOI:
10.4315/0362-028X.JFP-16-134

38. Antimicrobial activities of spice extracts against pathogenic and spoilage bacteria in modified atmosphere packaged fresh pork and vacuum packaged ham slices stored at 4°C

Author:
Zhang, Huiyun; Kong, Baohua; Xiong, Youling L.; Sun, Xu
Source:
Meat science 2009 v.81 no.4 pp. 686-692
ISSN:
0309-1740
Subject:
food spoilage; shelf life; Pseudomonas fluorescens; essential oils; plant extracts; food packaging; raw meat; bacterial contamination; modified atmosphere packaging; vacuum packaging; food storage; Listeria monocytogenes; Escherichia coli; Cassia; food preservation; ham; Lactobacillus sakei; rosemary; refrigeration; licorice; food preservatives; antibacterial properties; cloves; natural additives; food pathogens; slicing; bark; cold storage
Abstract:
... The antimicrobial activity of 14 spice extracts against four common meat spoilage and pathogenic bacteria (Listeria monocytogenes, Escherichia coli, Pseudomonas fluorescens and Lactobacillus sake) was screened in cultured media (experiment 1). The results showed that individual extracts of clove, rosemary, cassia bark and liquorice contained strong antimicrobial activity, but the mixture of rosema ...
DOI:
10.1016/j.meatsci.2008.11.011
PubMed:
20416570

39. Antimicrobial and antioxidant activities of medicinal plant Glycyrrhiza glabra var. glandulifera from different habitats

Author:
Faruk Karahan; Cumhur Avsar; Ibrahim Ilker Ozyigit; Ismet Berber
Source:
Biotechnology, biotechnological equipment 2016 v.30 no.4 pp. 797-804
ISSN:
1314-3530
Subject:
2,2-diphenyl-1-picrylhydrazyl; Candida; Glycyrrhiza glabra; antimicrobial properties; antioxidant activity; antioxidants; biotechnology; equipment; habitats; licorice; medicinal plants; minimum inhibitory concentration; roots; yeasts
Abstract:
... In this study, the antimicrobial and antioxidant activities of root methanolic extracts of Glycyrrhiza glabra var. glandulifera (Waldst. & Kit.) Boiss. (Fabaceae) were investigated. Plant samples were collected from different habitats in the East Mediterranean part of Turkey. The plant extracts were evaluated for antimicrobial activities against nine bacterial and two yeast strains using disc-diff ...
DOI:
10.1080/13102818.2016.1179590

40. Antimicrobial potential of Glycyrrhiza glabra roots

Author:
Gupta, Vivek K.; Fatima, Atiya; Faridi, Uzma; Negi, Arvind S.; Shanker, Karuna; Kumar, J.K.; Rahuja, Neha; Luqman, Suaib; Sisodia, Brijesh S.; Saikia, Dharmendra; Darokar, M.P.; Khanuja, Suman P.S.
Source:
Journal of ethnopharmacology 2008 v.116 no.2 pp. 377-380
ISSN:
0378-8741
Subject:
Glycyrrhiza glabra; licorice; roots; medicinal plants; antimicrobial properties; fractionation; bioassays; Mycobacterium tuberculosis; in vitro studies; Gram-positive bacteria; Gram-negative bacteria
Abstract:
... The present study was aimed to investigate antimicrobial potential of Glycyrrhiza glabra roots. Antimycobacterial activity of Glycyrrhiza glabra was found at 500μg/mL concentration. Bioactivity guided phytochemical analysis identified glabridin as potentially active against both Mycobacterium tuberculosis H₃₇Ra and H₃₇Rv strains at 29.16μg/mL concentration. It exhibited antimicrobial activity agai ...
DOI:
10.1016/j.jep.2007.11.037
PubMed:
18182260

41. Antioxidant activity of spice extracts in a liposome system and in cooked pork patties and the possible mode of action

Author:
Kong, Baohua; Zhang, Huiyun; Xiong, Youling L.
Source:
Meat science 2010 v.85 no.4 pp. 772-778
ISSN:
0309-1740
Subject:
Cinnamomum aromaticum; antioxidant activity; antioxidants; cardamom; chelation; cloves; color; cooked foods; licorice; mechanism of action; metals; nutmeg; off flavors; patties; phenolic compounds; plant extracts; pork; rosemary
Abstract:
... Three experiments were conducted to assess the antioxidant efficacy of spice extracts in cooked meat. In experiment 1, antioxidant activity of 13 common spice extracts was screened in a liposome system. Six of the extracts (clove, rosemary, cassia bark, liquorice, nutmeg, and round cardamom), identified to have the greatest total phenolic contents, were strongly inhibitory of TBARS formation. In e ...
DOI:
10.1016/j.meatsci.2010.04.003
PubMed:
20430533

42. Antioxidant activity of traditional Chinese medicinal herbs

Author:
Lee, Y.C.; Chuah, A.M.; Yamaguchi, T.; Takamura, H.; Matoba, T.
Source:
Food science and technology research 2008 v.14 no.2 pp. 205-210
ISSN:
1344-6606
Subject:
tocopherols; Cassia; Chrysanthemum; free radicals; medicinal plants; phenolic compounds; herbal medicines; free radical scavengers; pharmacology; Poria; ascorbic acid; licorice; antioxidant activity; spices; roots; Oriental traditional medicine; Hibiscus; China
DOI:
10.3136/fstr.14.205

43. Antioxidant and Anti-Inflammatory Activities of Flavanones from Glycyrrhiza glabra L. (licorice) Leaf Phytocomplexes: Identification of Licoflavanone as a Modulator of NF-kB/MAPK Pathway

Author:
Luca Frattaruolo; Gabriele Carullo; Matteo Brindisi; Sarah Mazzotta; Luca Bellissimo; Vittoria Rago; Rosita Curcio; Vincenza Dolce; Francesca Aiello; Anna Rita Cappello
Source:
Antioxidants 2019 v.8 no.6 pp. -
ISSN:
2076-3921
Subject:
2,2-diphenyl-1-picrylhydrazyl; Glycyrrhiza glabra; agrochemicals; anti-inflammatory activity; anti-inflammatory agents; antioxidant activity; biochemical pathways; cell viability; chemical composition; cytokines; flavanones; fractionation; inducible nitric oxide synthase; inflammation; leaf extracts; leaves; licorice; lipopolysaccharides; maceration; macrophages; mice; mitogen-activated protein kinase; nitrites; prostaglandin synthase; sulfonic acids; traditional medicine; transcription factor NF-kappa B; ultrasonic treatment; wastes
Abstract:
... Inflammation represents an adaptive response generated by injuries or harmful stimuli. Natural remedies represent an interesting alternative to traditional therapies, involving several biochemical pathways. Besides, the valorization of agrochemical wastes nowadays seems to be a feasible way to reduce the health spending and improve the accessibility at bioactive natural compounds. In this context, ...
DOI:
10.3390/antiox8060186
PubMed:
31226797
PubMed Central:
PMC6616548

44. Antioxidant and Antiaging Effects of Licorice on the Caenorhabditis elegans Model

Author:
Inés Reigada; Cristina Moliner; Marta Sofía Valero; David Weinkove; Elisa Langa; Carlota Gómez Rincón
Source:
Journal of medicinal food 2020 v.23 no.1 pp. 72-78
ISSN:
1557-7600
Subject:
2,2-diphenyl-1-picrylhydrazyl; Caenorhabditis elegans; Glycyrrhiza glabra; animal models; anti-aging properties; antioxidant activity; antioxidants; diet; free radicals; inhibitory concentration 50; juglone; licorice; longevity; oxidants; oxidative stress; phytochemicals; roots; stress tolerance; survival rate
Abstract:
... The causative relationship between oxidative stress and aging remains controversial, but it is a fact that many of the pathologies of age-related diseases are associated with oxidative stress. Phytochemicals may reduce damage from oxidative stress; the intake of these through diet could represent a strategy to lessen their pathological consequences. The popular and widely consumed licorice (Glycyr ...
DOI:
10.1089/jmf.2019.0081

45. Antioxidant and anti-inflammatory activities of six flavonoids separated from licorice

Author:
Yu Fu; Jun Chen; Yan-Jing Li; Yun-Feng Zheng; Ping Li
Source:
Food chemistry 2013 v.141 no.2 pp. 1063-1071
ISSN:
0308-8146
Subject:
Glycyrrhiza uralensis; antioxidant activity; flavonoids; herbal medicines; interleukin-6; licorice; lipid peroxidation; liver microsomes; nitric oxide; rats; reactive oxygen species; rhizomes; roots; sweeteners
Abstract:
... Licorice, the roots and rhizomes of several Glycyrrhiza species (Leguminosae), is an important natural sweetening agent and a widely used herbal medicine. In this work, six flavonoids, 5-(1,1-dimethylallyl)-3,4,4′-trihydroxy-2-methoxychalcone (1), licochalcone B (2), licochalcone A (3), echinatin (4), glycycoumarin (5) and glyurallin B (6), were isolated from the extracts of licorice (Glycyrrhiza ...
DOI:
10.1016/j.foodchem.2013.03.089
PubMed:
23790887

46. Antioxidant and anti-inflammatory activities of water distillate and its dichloromethane extract from licorice root (Glycyrrhiza uralensis) and chemical composition of dichloromethane extract

Author:
Tanaka, Aki; Horiuchi, Masahiro; Umano, Katsummi; Shibamoto, Takayuki
Source:
Journal of the science of food and agriculture 2008 v.88 no.7 pp. 1158-1165
ISSN:
0022-5142
Subject:
Glycyrrhiza uralensis; licorice; medicinal plants; roots; plant extracts; antioxidant activity; anti-inflammatory activity; antioxidants; chemical composition
Abstract:
... BACKGROUND:Licorice root is one of the most widely used medicinal herbs and its medicinal properties, such as antibacterial, anti-ulcer, anti-tumorigenic and anti-atherosclerotic activities, have been widely reported. However, there are only a few reports on basic chemical and biological studies of the water distilled components of licorice root.RESULTS:Chinese licorice root was water distilled an ...
DOI:
10.1002/jsfa.3191

47. Antioxidant and antimicrobial assessment of licorice supercritical extracts

Author:
Somaris E. Quintana; Carolina Cueva; David Villanueva-Bermejo; M. Victoria Moreno-Arribas; Tiziana Fornari; Mónica R. García-Risco
Source:
Industrial crops and products 2019 v.139 pp. 111496
ISSN:
0926-6690
Subject:
Glycyrrhiza glabra; antimicrobial properties; antioxidant activity; antioxidants; bioactive compounds; carbon dioxide; ethanol; fractionation; glycyrrhizin; herbal medicines; high performance liquid chromatography; licorice; phenolic compounds; roots
Abstract:
... Licorice (Glycyrrhiza glabra L.) is a plant used widely in herbal medicines due to their several biological potentials. The supercritical extraction of licorice roots was investigated to assess the antioxidant and antimicrobial activity of the extracts. Extraction conditions were pressures from 15 to 40 MPa, 313.15 and 333.15 K, and ethanol cosolvent in the range of 0 to 20% mass. In the case of h ...
DOI:
10.1016/j.indcrop.2019.111496

48. Antioxidant effect of acerola fruit powder, rosemary and licorice extract in caiman meat nuggets containing mechanically separated caiman meat

Author:
Gilmar Borges de Paiva; Marco Antonio Trindade; Javier Telis Romero; Andrea Carla da Silva-Barretto
Source:
Meat science 2021 v.173 pp. 108406
ISSN:
0309-1740
Subject:
acerolas; antioxidant activity; antioxidants; cohesion; color; frozen storage; isoascorbic acid; licorice; meat; meat science; rosemary; sensory evaluation; storage time
Abstract:
... The aim of this work was to evaluate the antioxidant effect of acerola fruit powder, rosemary and licorice extract in caiman meat nuggets containing high amounts of mechanically separated caiman meat (MSCM) during 120 days of frozen storage. Five treatments were prepared: a control without antioxidant (CON), sodium erythorbate at 500 mg/kg (ERY), acerola fruit powder at 500 mg/kg (AFP), with licor ...
DOI:
10.1016/j.meatsci.2020.108406

49. Antioxidant effects of liquorice (Glycyrrhiza uralensis) extract during aging of longissimus thoracis muscle in Tan sheep

Author:
Yuwei Zhang; Hailing Luo; Kun Liu; Huina Jia; Yong Chen; Zhenzhen Wang
Source:
Meat science 2015 v.105 pp. 38-45
ISSN:
0309-1740
Subject:
Glycyrrhiza uralensis; antioxidant activity; dietary supplements; dose response; free radical scavengers; licorice; longissimus muscle; meat; reactive oxygen species; sheep; thiobarbituric acid-reactive substances
Abstract:
... The study was conducted to investigate the potential of liquorice extract (LE) from Glycyrrhiza uralensis as a dietary supplement for sheep to improve antioxidant capacity of meat. Fifty Tan sheep were randomly allocated to five groups with LE supplementation at levels of 0, 1000, 2000, 3000 and 4000mg/kg feed. After 120days, the longissimus thoracis muscle was sampled and conditioned for 0, 2, 4, ...
DOI:
10.1016/j.meatsci.2015.03.002

50. Antioxidative and anticancer properties of Licochalcone A from licorice

Author:
Xiangrong Chen; Zuojia Liu; Rizeng Meng; Ce Shi; Na Guo
Source:
Journal of ethnopharmacology 2017 v.198 pp. 331-337
ISSN:
0378-8741
Subject:
Western blotting; antineoplastic activity; antioxidant activity; apoptosis; catalase; cell proliferation; cell viability; chalcone; dose response; free radicals; human cell lines; licorice; life cycle assessment; median effective concentration; medicinal plants; mitogen-activated protein kinase; neoplasm cells; neoplasms; oxidation; proteins; signal transduction; superoxide dismutase; traditional medicine
Abstract:
... Licochalcone A (LCA) is a characteristic chalcone that is found in licorice, which is a traditional medicinal plant. In traditional medicine, LCA possesses many potential biological activities, including anti-parasitic, anti-inflammatory and antitumor activities.To determine the antioxidant activity of LCA and, on this basis, to investigate the role of its anticancer activity.To validate the antio ...
DOI:
10.1016/j.jep.2017.01.028

51. Antiparasitic Efficacy of Crude Plant Extracts and Compounds Purified from Plants against the Fish Monogenean Neobenedenia girellae

Author:
Hui‐Ru Liu; Yan‐Meng Liu; Ting‐Long Hou; Chun‐Tao Li; Qi‐Zhong Zhang
Source:
Journal of aquatic animal health 2021 v.33 no.3 pp. 155-161
ISSN:
0899-7659
Subject:
Astragalus membranaceus; Dryopteris; Glycyrrhiza uralensis; Neobenedenia; Punica granatum; Salvia miltiorrhiza; adults; animal health; antiparasitic agents; curcumin; ectoparasites; emodin; ethanol; ferns and fern allies; licorice; mariculture; mortality; phytochemicals; pomegranates; sage; wood; North America
Abstract:
... Neobenedenia girellae is a pathogenic ectoparasite of many marine fishes, and it causes major epidemics in marine aquaculture. In this study, the efficacy of ethanol extracts of huangqi Astragalus membranaceus (known as milkvetch in North America), guanzhong Dryopteris setosa (known as beaded wood fern in North America), gancao Glycyrrhiza uralensis (known as Chinese licorice in North America), da ...
DOI:
10.1002/aah.10128

52. Antitoxin Characteristic of Licorice Extract: The Inhibitory Effect on Aflatoxin Production in Aspergillus parasiticus

Author:
Rashin Mohseni; Fatemeh Noorbakhsh; Maryam Moazeni; Ayatolah Nasrollahi Omran; Sassan Rezaie
Source:
Journal of food safety 2014 v.34 no.2 pp. 119-125
ISSN:
0149-6085
Subject:
Aspergillus parasiticus; Glycyrrhiza glabra; adverse effects; aflatoxins; antifungal agents; antifungal properties; antitoxins; crops; fungi; gene expression; genes; humans; licorice; liquid chromatography; messenger RNA; microbial growth; polymerase chain reaction; therapeutics
Abstract:
... Recent investigations revealed the effects of herbal extracts on both fungal growth as well as aflatoxins production. In the present study, we tried to evaluate antifungal activity as well as antitoxin activity of Glycyrrhiza glabra (licorice) extract. Strain American Type Culture Collection 15517 of Aspergillus parasiticus was used to perform antifungal susceptibility test according to Clinical a ...
DOI:
10.1111/jfs.12104

53. Antitussive, anti-pyretic and toxicological evaluation of Ma-Xing-Gan-Shi-Tang in rodents

Author:
Yu-Chin Lin; Ching-Wen Chang; Chi-Rei Wu
Source:
BMC complementary and alternative medicine 2016 v.16 no.1 pp. 456
ISSN:
1472-6882
Subject:
acetylcholine; adverse effects; alternative medicine; amygdalin; cough; dose response; ephedrine; fever; glycyrrhizin; guinea pigs; gypsum; high performance liquid chromatography; histamine; histology; inflammation; licorice; lipopolysaccharides; medicinal plants; medicinal properties; oral administration; pneumonia; rats; receptors; smooth muscle; toxicity testing
Abstract:
... BACKGROUND: Ma-Xing-Gan-Shi-Tang (abbreviated as MXGST), an important Chinese herbal prescribed for cough, bronchial inflammation and fever from pneumonia, consists of four medicinal herbs, including Ephedrae herb, Semen Pruni Armeniacae, licorice and Gypsum. These components, especially Ephedrae and Semen Pruni Armeniacae, possess antitussive activities, but they have severe adverse effects. METH ...
DOI:
10.1186/s12906-016-1440-2
PubMed:
27832784
PubMed Central:
PMC5105301

54. Antiviral effects of Glycyrrhiza species

Author:
Fiore, Cristina; Eisenhut, Michael; Krausse, Rea; Ragazzi, Eugenio; Pellati, Donatella; Armanini, Decio; Bielenberg, Jens
Source:
Phytotherapy research 2008 v.22 no.2 pp. 141-148
ISSN:
0951-418X
Subject:
Glycyrrhiza glabra; Hepatitis B virus; Influenza A virus; T-lymphocytes; Vaccinia virus; Vesiculovirus; antiviral properties; arboviruses; cell membranes; chronic hepatitis B; enzyme inhibition; glycyrrhizin; hepatoma; herpes simplex; in vitro studies; interferons; licorice; membrane fluidity; mortality; patients; pneumonia; risk; surface antigens; China; Greece; India
Abstract:
... Historical sources for the use of Glycyrrhiza species include ancient manuscripts from China, India and Greece. They all mention its use for symptoms of viral respiratory tract infections and hepatitis. Randomized controlled trials confirmed that the Glycyrrhiza glabra derived compound glycyrrhizin and its derivatives reduced hepatocellular damage in chronic hepatitis B and C. In hepatitis C virus ...
DOI:
10.1002/ptr.2295
PubMed:
17886224

55. Application of Ultrasound and Natural Deep Eutectic Solvent for the Extraction of Glycyrrhizic Acid from Glycyrrhiza glabra: Optimization and Kinetic Evaluation

Author:
Kavita J. Lanjekar; Virendra K. Rathod
Source:
Industrial & engineering chemistry process design and development 2021 v.60 no.26 pp. 9532-9538
ISSN:
1520-5045
Subject:
Glycyrrhiza glabra; acoustics; choline chloride; glycyrrhizin; kinetics; lactic acid; licorice; liquids; process design; solvents; ultrasonic treatment; ultrasonics
Abstract:
... Nowadays, natural deep eutectic solvents (NADESs) are regarded as a green and sustainable substitute to traditional organic solvents for the extraction of bioactive molecules. Similarly, ultrasound-assisted extraction (UAE) is an extensively acknowledged environment-friendly technique due to reduced solvent consumption and extraction time as well as enhanced extraction efficiency as compared to co ...
DOI:
10.1021/acs.iecr.1c00862

56. Application of an in vitro digestion model to study the metabolic profile changes of an herbal extract combination by UHPLC–HRMS

Author:
Timo A. Thumann; Eva-Maria Pferschy-Wenzig; Heba Aziz-Kalbhenn; Ramy M. Ammar; Sabine Rabini; Christine Moissl-Eichinger; Rudolf Bauer
Source:
Phytomedicine 2020 v.71 pp. 153221
ISSN:
0944-7113
Subject:
Angelica archangelica; Melissa officinalis; Mentha piperita nothosubsp. piperita; Silybum marianum; bioavailability; caffeic acid; caraway; chamomile; colon; digestion; fruits; in vitro digestion; in vitro studies; indigestion; intestinal microorganisms; isomerization; licorice; medicinal plants; metabolites; models; protein binding; roots
Abstract:
... STW 5 is a fixed herbal combination containing extracts from nine medicinal plants: bitter candytuft, greater celandine, garden angelica roots, lemon balm leaves, peppermint leaves, caraway fruits, licorice roots, chamomile flowers, and milk thistle fruit. STW 5 is a clinically proven treatment for functional dyspepsia and irritable bowel syndrome.Using a static in vitro method, we simulated oral, ...
DOI:
10.1016/j.phymed.2020.153221

57. Application of ultrasound-assisted processing in improving the purification effect and bioactivity of licorice flavonoids from licorice residues

Author:
Zhonghua Luo; Xude Wang; Qingqing Gao; Zhenghong Guo; Wei Li; Yuqing Zhao
Source:
Industrial crops and products 2021 v.167 pp. 113544
ISSN:
0926-6690
Subject:
Glycyrrhiza glabra; adsorption; apoptosis; bioactive compounds; cardiomyocytes; chalcones; desorption; energy density; hydrogen peroxide; licorice; protective effect; purification methods; temperature; ultrasonic treatment
Abstract:
... Licorice residues are rich in flavonoids and are considered to be valuable reusable resources with broad applications and a high economic value. In view of above, the ultrasound-assisted adsorption/desorption of licorice flavonoids (LFs) on HPD-100 resins was studied. This process was studied at different temperatures (20–30 ℃) using ultrasound at different power densities (0.2, 0.35, 0.5 W/cm²). ...
DOI:
10.1016/j.indcrop.2021.113544

58. Aqueous extracts and polysaccharides from Liquorice roots (Glycyrrhiza glabra L.) inhibit adhesion of Helicobacter pylori to human gastric mucosa

Author:
Wittschier, Nicole; Faller, Gerhard; Hensel, A.
Source:
Journal of ethnopharmacology 2009 v.125 no.2 pp. 218-223
ISSN:
0378-8741
Subject:
stomach ulcers; polysaccharides; Helicobacter pylori; gastric mucosa; Glycyrrhiza glabra; cytotoxicity; bacterial adhesion; medicinal plants; plant extracts; animal pathogenic bacteria; secondary metabolites; mouth; Porphyromonas gingivalis; licorice; medicinal properties; in vitro studies; tissue culture
Abstract:
... Aims: Aqueous extracts from the roots of Glycyrrhiza glabra L. (Fabaceae) are widely used for treatment of stomach ulcer. The clinical proven effects are related to the presence of anti-inflammatory 12-keto-triterpensaponins in the extracts. Apart from that the influence of Glycyrrhiza glabra extract on the bacterial adhesion of Helicobacter pylori to stomach tissue was to be investigated. Additio ...
DOI:
10.1016/j.jep.2009.07.009
PubMed:
19607905

59. Arbuscular Mycorrhizal Fungi Can Compensate for the Loss of Indigenous Microbial Communities to Support the Growth of Liquorice (Glycyrrhiza uralensis Fisch.)

Author:
Meng Yu; Wei Xie; Xin Zhang; Shubin Zhang; Youshan Wang; Zhipeng Hao; Baodong Chen
Source:
Plants 2019 v.9 no.1 pp. -
ISSN:
2223-7747
Subject:
Glycyrrhiza uralensis; Rhizophagus irregularis; adverse effects; agricultural management; biosynthesis; gene expression regulation; genes; glycyrrhizin; licorice; medicinal plants; microbial communities; mycorrhizal fungi; photosynthesis; plant growth; plant nutrition; secondary metabolites; soil; soil sterilization; vesicular arbuscular mycorrhizae
Abstract:
... Soil microorganisms play important roles in nutrient mobilization and uptake of mineral nutrition in plants. Agricultural management, such as soil sterilization, can have adverse effects on plant growth because of the elimination of indigenous microorganisms. Arbuscular mycorrhizal (AM) fungi are one of the most important beneficial soil microorganisms for plant growth. However, whether AM fungi c ...
DOI:
10.3390/plants9010007

60. Arbuscular Mycorrhizal Fungus Improves Rhizobium–Glycyrrhiza Seedling Symbiosis under Drought Stress

Author:
Zhipeng Hao; Wei Xie; Xuelian Jiang; Zhaoxiang Wu; Xin Zhang; Baodong Chen
Source:
Agronomy 2019 v.9 no.10 pp. -
ISSN:
2073-4395
Subject:
Glycyrrhiza uralensis; Mesorhizobium tianshanense; Rhizobium; Rhizophagus irregularis; drought tolerance; environmental factors; greenhouse experimentation; host plants; legumes; licorice; microsymbionts; mycorrhizal fungi; nitrogen content; nodulation; phosphorus content; plant nitrogen content; roots; seedling growth; seedlings; shoots; stress tolerance; vesicular arbuscular mycorrhizae; water stress
Abstract:
... Rhizobia and arbuscular mycorrhizal (AM) fungi can potentially alleviate the abiotic stress on the legume Glycyrrhiza (licorice), while the potential benefits these symbiotic microbes offer to their host plant are strongly influenced by environmental factors. A greenhouse pot experiment was conducted to investigate the effects of single and combined inoculation with a rhizobium Mesorhizobium tians ...
DOI:
10.3390/agronomy9100572

61. Arbuscular mycorrhiza facilitates the accumulation of glycyrrhizin and liquiritin in Glycyrrhiza uralensis under drought stress

Author:
Wei Xie; Zhipeng Hao; Xiaofu Zhou; Xuelian Jiang; Lijiao Xu; Songlin Wu; Aihua Zhao; Xin Zhang; Baodong Chen
Source:
Mycorrhiza 2018 v.28 no.3 pp. 285-300
ISSN:
0940-6360
Subject:
Glycyrrhiza uralensis; abscisic acid; active ingredients; aquaporins; biosynthesis; carbon; carbon nitrogen ratio; correlation; gene expression regulation; genes; glycyrrhizin; licorice; medicinal plants; nitrogen; phosphorus; photosynthesis; physiological state; plant growth; roots; stomatal conductance; supply balance; vesicular arbuscular mycorrhizae; water management; water stress; water treatment; water use efficiency
Abstract:
... Liquorice (Glycyrrhiza uralensis) is an important medicinal plant for which there is a huge market demand. It has been reported that arbuscular mycorrhizal (AM) symbiosis and drought stress can stimulate the accumulation of the active ingredients, glycyrrhizin and liquiritin, in liquorice plants, but the potential interactions of AM symbiosis and drought stress remain largely unknown. In the prese ...
DOI:
10.1007/s00572-018-0827-y

62. Aroma profile of malbec red wines from La Mancha region: Chemical and sensory characterization

Author:
E. Sánchez-Palomo; M. Trujillo; A. García Ruiz; M.A. González Viñas
Source:
Food research international 2017 v.100 pp. 201-208
ISSN:
0963-9969
Subject:
gas chromatography-mass spectrometry; grapes; leather; licorice; odor compounds; odors; red wines; sensory evaluation; solid phase extraction; tobacco
Abstract:
... The aroma of La Mancha Malbec red wines over four consecutive vintages was characterized by chemical and sensory analysis. Solid phase extraction (SPE) and gas chromatography–mass spectrometry (GC–MS) were used to isolate and analyze free volatile compounds. Quantitative Descriptive Sensory Analysis (QDA) was carried out to characterize the sensory aroma profile. A total of 79 free volatile compou ...
DOI:
10.1016/j.foodres.2017.06.036

63. Aspergillus niger Enhance Bioactive Compounds Biosynthesis As Well As Expression of Functional Genes in Adventitious Roots of Glycyrrhiza uralensis Fisch

Author:
Jing Li; Juan Wang; Jinxin Li; Dahui Liu; Hongfa Li; Wenyuan Gao; Jianli Li; Shujie Liu
Source:
Applied biochemistry and biotechnology 2016 v.178 no.3 pp. 576-593
ISSN:
0273-2289
Subject:
Aspergillus niger; Glycyrrhiza uralensis; adventitious roots; aeration; bioreactors; biosynthesis; catalase; cytochrome P-450; electrospray ionization mass spectrometry; elicitors; flavonoids; fungi; gene expression regulation; genes; licorice; metabolites; peroxidase; polysaccharides; salicylic acid; saponins; squalene; superoxide dismutase; trans-cinnamate 4-monooxygenase
Abstract:
... In the present study, the culture conditions for the accumulation of Glycyrrhiza uralensis adventitious root metabolites in balloon-type bubble bioreactors (BTBBs) have been optimized. The results of the culture showed that the best culture conditions were a cone angle of 90° bioreactor and 0.4–0.6–0.4-vvm aeration volume. Aspergillus niger can be used as a fungal elicitor to enhance the productio ...
DOI:
10.1007/s12010-015-1895-5

64. Assessment of General Toxicity of the Glycyrrhiza New Variety Extract in Rats

Author:
Dong-Gu Kim; Jeonghoon Lee; Wonnam Kim; Hyo-Jin An; Jong-Hyun Lee; Jaeki Chang; Sa-Haeng Kang; Young-Jae Song; Yong-Deok Jeon; Jong-Sik Jin
Source:
Plants 2021 v.10 no.6 pp. -
ISSN:
2223-7747
Subject:
Glycyrrhiza; asthma; cold; cough; dose response; gastritis; hematology; licorice; mortality; new variety; no observed adverse effect level; ophthalmology; oral administration; respiratory system; rural development; toxicology; China; India; Korean Peninsula
Abstract:
... The Glycyrrhiza radix (Licorice) is one of the most commonly used medicinal plants in Asian countries, such as China, India, and Korea. It has been traditionally used to treat many diseases, including cough, cold, asthma, fatigue, gastritis, and respiratory tract infections. A Glycyrrhiza new variety, Wongam (WG), has been developed by the Korea Rural Development Administration and revealed pharma ...
DOI:
10.3390/plants10061126

65. Assessment of squalene synthase and beta-amyrin synthase gene expression in licorice roots treated with methyl jasmonate and salicylic acid using real-time qPCR

Author:
Shabani, L.; Ehsanpour, A. A.; Esmaeili, A.
Source:
Russian journal of plant physiology 2010 v.57 no.4 pp. 480-484
ISSN:
1021-4437
Subject:
biosynthesis; complementary DNA; elicitors; enzymes; gene expression; genes; glycyrrhizin; licorice; methyl jasmonate; plantlets; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; reverse transcription; ribosomal RNA; roots; salicylic acid; squalene; terpenoids
Abstract:
... Expression of two key biosynthetic enzymes for terpenoid biosynthesis (squalene synthase and beta-amyrin synthase) was analyzed in licorice as a model organism. For two elicitors, methyl jasmonate (MeJa) and salicylic acid (SA), the roots of 65-day-old plantlets treated with a combination of various elicitor concentrations and treatment times were used for RNA extraction and reverse transcription ...
DOI:
10.1134/S1021443710040047

66. Assessment of the inhibition potential of Licochalcone A against human UDP-glucuronosyltransferases

Author:
Hong Xin; Xiao-Yi Qi; Jing-Jing Wu; Xin-Xin Wang; Yan Li; James Y. Hong; Wei He; Wei Xu; Guang-Bo Ge; Ling Yang
Source:
Food and chemical toxicology 2016 v.90 pp. 112-122
ISSN:
0278-6915
Subject:
bioactive compounds; herbal medicines; humans; inhibitory concentration 50; licorice; life cycle assessment; liver microsomes; risk
Abstract:
... Licochalcone A (LCA) is a major bioactive compound in Licorice, a widely used herbal medicine. In this study, the inhibitory effects of LCA against human UDP-glucuronosyltransferases (UGTs) and LCA associated herb-drug interactions were systematically investigated. Our results demonstrated that LCA displayed broad-spectrum inhibition against human UGTs. LCA exhibited strong inhibitory effects agai ...
DOI:
10.1016/j.fct.2016.02.007

67. Association analysis and molecular tagging of phytochemicals in the endangered medicinal plant licorice (Glycyrrhiza glabra L.)

Author:
Marjan Sadat Hosseini; Morteza Ebrahimi; Davood Samsampour; Javier Abadía; Morteza Khanahmadi; Rasool Amirian; Iman Naseh Ghafoori; Mostafa Ghaderi-Zefrehei; Yolanda Gogorcena
Source:
Phytochemistry 2021 v.183 pp. 112629
ISSN:
0031-9422
Subject:
Glycyrrhiza glabra; amplified fragment length polymorphism; antioxidants; biodiversity; domestication; endangered species; genetic markers; genetic variation; genotype; glycyrrhizin; licorice; medicinal plants; phenolic compounds; phenotype; phytochemicals; plant breeding; population structure; wild relatives; Iran
Abstract:
... Licorice (Glycyrrhiza glabra L.) is a medicinal plant species valued in many countries in Asia and Europe for its phytochemical characteristics. Licorice biodiversity is becoming threatened nowadays in Iran due to increasing demand and a drastic decline of its natural habitats. Therefore, licorice domestication would be necessary in the near future, and molecular breeding would help to introduce g ...
DOI:
10.1016/j.phytochem.2020.112629

68. Attitudes and knowledge toward natural products safety in the pharmacy setting: an Italian study

Author:
Cuzzolin, Laura; Benoni, Giuseppina
Source:
Phytotherapy research 2009 v.23 no.7 pp. 1018-1023
ISSN:
0951-418X
Subject:
Ginkgo; Panax; Paullinia cupana; adverse effects; attitudes and opinions; cartilage; chamomile; garlic; glucomannans; hypotension; interviews; licorice; propolis; questionnaires; risk; sharks; surveys; thyme
Abstract:
... The lack of a professional supervision may expose consumers of natural products to risks; pharmacists play an important role in giving information about these substances. A survey was designed to investigate the attitudes and knowledge of consumers and pharmacists toward the safety of natural products. Twenty-three pharmacies participated in the project. On the basis of a pre-structured 17-item qu ...
DOI:
10.1002/ptr.2745
PubMed:
19140118

69. Autophagy Activation and Antiviral Activity by a Licorice Triterpene

Author:
Samuela Laconi; Maria A. Madeddu; Raffaello Pompei
Source:
Phytotherapy research 2014 v.28 no.12 pp. 1890-1892
ISSN:
0951-418X
Subject:
Glycyrrhiza glabra; anti-inflammatory activity; antiviral properties; autophagy; epithelial cells; glycyrrhizin; licorice; medicinal plants; triterpenoids; viruses
Abstract:
... The triterpene glycyrrhizic acid (GRA), the main product from the Glycyrrhiza glabra medicinal plant, is known for its antiinflammatory and antimicrobial activity. In this work, GRA was studied for its ability to induce the autophagic process activator Beclin 1 in epithelial cells and to observe how this property could influence its antiviral activity. After 24 h of treatment, GRA induced a Beclin ...
DOI:
10.1002/ptr.5189

70. Bacillus pumilus improved drought tolerance in Glycyrrhiza uralensis G5 seedlings through enhancing primary and secondary metabolisms

Author:
Xinhui Zhang; Zhicai Xie; Duoyong Lang; Yuankui Chu; Gaochang Cui; Xiaoxia Jia
Source:
Physiologia plantarum 2021 v.171 no.3 pp. 388-399
ISSN:
0031-9317
Subject:
Bacillus pumilus; Glycyrrhiza uralensis; biomass; biosynthesis; drought tolerance; glycyrrhizin; licorice; nitrogen metabolism; plant growth-promoting rhizobacteria; secondary metabolites; sugars; water stress
Abstract:
... It has been reported that drought stress adversely affects the growth and yield of Glycyrrhiza uralensis, Chinese liquorice, in agricultural production. Bacillus pumilus, an important plant growth‐promoting bacterium, play a significant role in improving plant tolerance to abiotic stress. However, the role of Bacillus pumilus G5 in resisting drought stress is largely unknown. In the present study, ...
DOI:
10.1111/ppl.13236

71. Based on multiple environmental factors to explore the habitat distribution of licorice (Glycyrrhiza uralensis) in different time and space

Author:
Qianqian Li; Xuehong Wang; Kaijing Yan; Zongsuo Liang; Pengguo Xia
Source:
Biochemical systematics and ecology 2022 v.105 pp. 104490
ISSN:
0305-1978
Subject:
Glycyrrhiza uralensis; atmospheric precipitation; chemotaxonomy; climate; climate change; economic valuation; environmental factors; geographical distribution; habitat fragmentation; habitats; humans; licorice; medicinal plants; temperature; topography; China
Abstract:
... As a traditional medicinal plant, licorice (Glycyrrhiza uralensis) with high medicinal and economic value and its demand is increasing around the world. In recent decades, the endless human excavation and climate change have reduced the natural habitat of licorice. Identifying the suitable habitat of licorice and climatic factors is crucial to formulating effective protection and management strate ...
DOI:
10.1016/j.bse.2022.104490

72. The Basic Helix–Loop–Helix Transcription Factor GubHLH3 Positively Regulates Soyasaponin Biosynthetic Genes in Glycyrrhiza uralensis

Author:
Keita Tamura; Koki Yoshida; Yasuko Hiraoka; Daiki Sakaguchi; Ayaka Chikugo; Keiichi Mochida; Mareshige Kojoma; Nobutaka Mitsuda; Kazuki Saito; Toshiya Muranaka; Hikaru Seki
Source:
Plant & cell physiology 2018 v.59 no.4 pp. 783-796
ISSN:
1471-9053
Subject:
Glycyrrhiza uralensis; basic helix-loop-helix transcription factors; biosynthesis; cytochrome P-450; enzymes; gene expression regulation; gene overexpression; genes; genetically modified organisms; glycyrrhizin; hydroxylation; legumes; licorice; medicinal plants; methyl jasmonate; roots; transcription (genetics); triterpenoid saponins
Abstract:
... Glycyrrhiza uralensis (licorice) is a widely used medicinal plant belonging to the Fabaceae. Its main active component, glycyrrhizin, is an oleanane-type triterpenoid saponin widely used as a medicine and as a natural sweetener. Licorice also produces other triterpenoids, including soyasaponins. Recent studies have revealed various oxidosqualene cyclases and cytochrome P450 monooxygenases (P450s) ...
DOI:
10.1093/pcp/pcy046

73. Benign development of cotton with antibacterial activity and metal sorpability through introduction amino triazole moieties and AgNPs in cotton structure pre-treated with periodate

Author:
Amina L. Mohamed; Ahmed G. Hassabo; S. Shaarawy; A. Hebeish
Source:
Carbohydrate polymers 2017 v.178 pp. 251-259
ISSN:
0144-8617
Subject:
cotton; Escherichia coli; nitrogen; sorption; triazoles; models; nanosilver; silver; cellulose; particle size; sorption isotherms; cotton fabric; licorice; metal ions; aldehydes; bacteria; antibacterial properties
Abstract:
... The research work presented herein was undertaken with a view to develop, characterize and highlight modified cotton fabrics that acquire durable antibacterial activity in concomitant with high metal sorption capacity. The development is based on reacting cotton cellulose previously oxidized by sodium periodate-with 4 amino-1,2,4 triazole in presence and absence of silver nano particles (AgNPs). T ...
DOI:
10.1016/j.carbpol.2017.09.024

74. Biliary Excretion of Glycyrrhetinic Acid: Glucuronide‐Conjugate Determination Following a Pharmacokinetic Study of Rat Bile

Author:
Yang Lu; Jing Jing; Weichao Ren; Jing Zhu; Zhixia Qiu; Ning Li; Xiaonan Li; Di Zhao; Harendra S. Parekh; Xijing Chen
Source:
Phytotherapy research 2014 v.28 no.12 pp. 1887-1889
ISSN:
0951-418X
Subject:
Oriental traditional medicine; bile; biotransformation; excretion; high performance liquid chromatography; humans; intravenous injection; licorice; metabolites; pharmacokinetics; rats; toxicity
Abstract:
... Liquorice is a commonly prescribed herb in traditional Chinese medicine with the primary constituent, glycyrrhetinic acid (GA) responsible for the toxic effects arising from its chronic consumption. Hepatic transformation and biliary excretion of GA are significant and well‐documented pharmacokinetic pathways in humans, while glucuronide conjugates are the major identified metabolites. Here we rep ...
DOI:
10.1002/ptr.5170

75. Binding effect of fluorescence labeled glycyrrhetinic acid with GA receptors in hepatocellular carcinoma cells

Author:
Yu-qi Sun; Chun-mei Dai; Yan Zheng; Shu-dan Shi; Hai-yang Hu; Da-wei Chen
Source:
Life sciences 2017 v.188 pp. 186-191
ISSN:
0024-3205
Subject:
Oriental traditional medicine; cytotoxicity; dissociation; fluorescence; hepatocytes; hepatoma; human cell lines; licorice; ligands; neoplasm cells; receptors; synthesis
Abstract:
... Glycyrrhetinic acid (GA) is a natural active component from licorice, which is broadly used in traditional Chinese medicine. Lots of glycyrrhetinic acid receptors (GA-R) are proved to locate on the surface of liver cells. Many reports about the hepatocellular carcinoma (HCC) treatment were dependent on GA modified carriers. However, the reality of GA-R in HCC cells was not clear. In this paper, 18 ...
DOI:
10.1016/j.lfs.2017.07.032

76. Bioactive Candy: Effects of Licorice on the Cardiovascular System

Author:
Mikkel R. Deutch; Daniela Grimm; Markus Wehland; Manfred Infanger; Marcus Krüger
Source:
Foods 2019 v.8 no.10 pp. -
ISSN:
2304-8158
Subject:
active ingredients; candy; cardiovascular diseases; cardiovascular system; cortisol; cortisone; diastolic blood pressure; enzyme inhibition; food intake; glycyrrhizin; hypokalemia; intestines; kidneys; licorice; long term effects; meta-analysis; metabolites; mineralocorticoid receptors; patients; tea; tobacco
Abstract:
... Licorice, today chiefly utilized as a flavoring additive in tea, tobacco and candy, is one of the oldest used herbs for medicinal purposes and consists of up to 300 active compounds. The main active constituent of licorice is the prodrug glycyrrhizin, which is successively converted to 3β-monoglucuronyl-18β-glycyrrhetinic acid (3MGA) and 18β-glycyrrhetinic acid (GA) in the intestine ...
DOI:
10.3390/foods8100495
PubMed:
31615045
PubMed Central:
PMC6836258

77. Bioactive Compounds and Their Effect on Blood Pressure—A Review

Author:
Bartosz Malinowski; Raul Ignacio Fajardo Leighton; Christopher George Hill; Paweł Szandorowski; Michał Wiciński
Source:
Nutrients 2020 v.12 no.6 pp. -
ISSN:
2072-6643
Subject:
Dietary Approaches to Stop Hypertension diet; anthocyanins; bioactive compounds; blood; blood pressure; cardiovascular diseases; chemical elements; docosahexaenoic acid; elderly; exhibitions; fasting; licorice; lycopene; nutrients; population; research; risk factors
Abstract:
... Elevated blood pressure affects a great part of the elderly population and is the leading risk factor for cardiovascular disease. New approaches have been taken in the fight against this growing problem, in the form of diets (Mediterranean, Dietary Approaches to Stop Hypertension (DASH) and intermittent fasting). Recent research has shown the promising results regarding diets and their effect on t ...
DOI:
10.3390/nu12061659

78. Bioactive Constituents of Glycyrrhiza uralensis (Licorice): Discovery of the Effective Components of a Traditional Herbal Medicine

Author:
Ji Shuai; Li Ziwei; Song Wei; Wang Yongrui; Liang Wenfei; Li Kai; Tang Shunan; Wang Qi; Qiao Xue; Zhou Demin; Yu Siwang; Ye Min
Source:
Journal of natural products 2016 v.79 no.2 pp. 281-292
ISSN:
1520-6025
Subject:
Glycyrrhiza uralensis; Influenza A virus; bioactive compounds; bioassays; cytotoxicity; hepatoprotective effect; herbal medicines; licorice; liver; mice; neoplasm cells; neoplasms; nitric oxide; phenolic compounds; rhizomes; roots; transcription factor NF-kappa B
Abstract:
... Traditional herbal medicines have been reported to possess significant bioactivities. In this investigation, a combined strategy using both phytochemical and biological approaches was conducted to discern the effective components of licorice, a widely used herbal medicine. Altogether, 122 compounds (1–122), including six new structures (1–6), were isolated and identified from the roots and rhizome ...
DOI:
10.1021/acs.jnatprod.5b00877

79. Bioactive activities of natural products against herpesvirus infection

Author:
Myoungki Son; Minjung Lee; Gi-Ho Sung; Taeho Lee; Yu Su Shin; Hyosun Cho; Paul M. Lieberman; Hyojeung Kang
Source:
journal of microbiology 2013 v.51 no.5 pp. 545-551
ISSN:
1225-8873
Subject:
DNA; Gammaherpesvirinae; Herpesviridae infections; adults; antiviral agents; antiviral properties; drug resistance; drug therapy; glycyrrhizin; herbal medicines; humans; immune response; licorice; mechanism of action; microbiology; mutation; nucleosides; thymidine kinase
Abstract:
... More than 90% of adults have been infected with at least one human herpesvirus, which establish long-term latent infection for the life of the host. While anti-viral drugs exist that limit herpesvirus replication, many of these are ineffective against latent infection. Moreover, drug-resistant strains of herpesvirus emerge following chemotherapeutic treatment. For example, resistance to acyclovir ...
DOI:
10.1007/s12275-013-3450-9

80. Bioactive food foams stabilized by licorice extract/whey protein isolate/sodium alginate ternary complexes

Author:
Majid Nooshkam; Mehdi Varidi; Fatemeh Alkobeisi
Source:
Food hydrocolloids 2022 v.126 pp. 107488
ISSN:
0268-005X
Subject:
air; antioxidant activity; cohesion; energy content; firmness; foams; free radicals; gel electrophoresis; hydrocolloids; licorice; particle size; sodium; sodium alginate; surface tension; turbidity; viscoelasticity; viscosity; whey protein isolate
Abstract:
... Interactions among multi-component food matrices play a key role in modulating the foam properties. In this study, foams containing mixtures of sodium alginate (ALG; 0.5, 1.0, and 1.5% w/v), whey protein isolate (WPI; 0.2 and 0.6% w/v), and licorice extract (LE; 0.1, 0.3, and 0.5% w/v) were formed and characterized. The interactions between the components were confirmed by turbidity, ζ-potential, ...
DOI:
10.1016/j.foodhyd.2022.107488

81. Bioactivity and Potential Health Benefits of Licorice

Author:
Kao Tzu-Chien; Wu Chi-Hao; Yen Gow-Chin
Source:
Journal of agricultural and food chemistry 2014 v.62 no.3 pp. 542-553
ISSN:
1520-5118
Subject:
Oriental traditional medicine; adverse effects; alternative medicine; anti-inflammatory activity; anti-inflammatory agents; chemoprevention; flavor; functional foods; industry; licorice; tobacco
Abstract:
... Licorice is an herbal plant named for its unique sweet flavor. It is widely used in the food and tobacco industries as a sweetener. Licorice is also used in traditional Chinese medicine (TCM) and complementary medicine. Because the use of licorice has long been a part of TCM, the details of its therapeutic applications have been thoroughly established. In modern science, licorice is of interest be ...
DOI:
10.1021/jf404939f
PubMed:
24377378

82. Bioactivity-guided isolation of cytotoxic secondary metabolites from the roots of Glycyrrhiza glabra and elucidation of their mechanisms of action

Author:
Dicle Çevik; Ş. Burçin Yılmazgöz; Yüksel Kan; Ece Akhan Güzelcan; Irem Durmaz; Rengül Çetin-Atalay; Hasan Kırmızıbekmez
Source:
Industrial crops and products 2018 v.124 pp. 389-396
ISSN:
0926-6690
Subject:
Glycyrrhiza glabra; apoptosis; breasts; caspase-9; cell cycle; cell lines; cell proliferation; chloroform; chromatography; cytotoxicity; ethyl acetate; inhibitory concentration 50; licorice; mechanism of action; medicinal properties; methanol; neoplasm cells; neoplasms; nuclear magnetic resonance spectroscopy; roots; secondary metabolites; staining
Abstract:
... Licorice (Glycyrrhiza glabra L.) is one of the most widely used plants worldwide for its various pharmacological activities. The aim of this study was to isolate the potential cytotoxic secondary metabolites from the MeOH extract prepared from the roots of Glycyrrhiza glabra through bioactivity-guided isolation procedure and to elucidate their mechanisms of action. The crude MeOH extract as well a ...
DOI:
10.1016/j.indcrop.2018.08.014

83. Biochar Amendments Improve Licorice (Glycyrrhiza uralensis Fisch.) Growth and Nutrient Uptake under Salt Stress

Author:
Dilfuza Egamberdieva; Hua Ma; Burak Alaylar; Zohreh Zoghi; Aida Kistaubayeva; Stephan Wirth; Sonoko Dorothea Bellingrath-Kimura
Source:
Plants 2021 v.10 no.10 pp. -
ISSN:
2223-7747
Subject:
Glycyrrhiza uralensis; acid phosphatase; biochar; biomass; carbon; corn; drought tolerance; enzyme activity; fluorescein diacetate; legumes; licorice; nitrogen; nodulation; nutrient uptake; phosphorus; plant tissues; proteinases; pyrolysis; root systems; saline soils; salt stress; soil enzymes; surface area
Abstract:
... Licorice (Glycyrrhiza uralensis Fisch.) is a salt and drought tolerant legume suitable for rehabilitating abandoned saline lands, especially in dry arid regions. We hypothesized that soil amended with maize-derived biochar might alleviate salt stress in licorice by improving its growth, nutrient acquisition, and root system adaptation. Experiments were designed to determine the effect of different ...
DOI:
10.3390/plants10102135

84. Bioconversion of glycyrrhizinic acid in liquorice into 18-β-glycyrrhetinic acid by Aspergillus parasiticus Speare BGB

Author:
Wang, J.; Sun, Q.; Gao, P.; Wang, J. F.; Xu, C.; Sun, Q. L.
Source:
Applied biochemistry and microbiology 2010 v.46 no.4 pp. 421-425
ISSN:
0003-6838
Subject:
Aspergillus parasiticus; absorption; beta-glucuronidase; biotransformation; chromatography; fermentation; fungi; glycyrrhizin; inoculum; licorice; molecular weight; nuclear magnetic resonance spectroscopy; pH; silica gel; temperature
Abstract:
... A filamentous fungi strain, Aspergillus parasiticus Speare BGB, producing (β-glucuronidase was screened to transform glycyrrhizinic acid (GL) in liquorice into 18-β-glycyrrhetinic acid (GA). Under the following cultivate conditions in shake flask, 1% GL (purity 30%), medium capacity 40% of flask, the initial pH value at 4.5, cultivate temperature of 32°C, inoculum size of 5% and culturing time for ...
DOI:
10.1134/S0003683810040101

85. Biological Activity and Pharmacokinetic Behavior of Fenbendazole Integrated into a Supramolecular Delivery System with Licorice Extract and Sodium Dioctyl Sulfosuccinate

Author:
A. I. Varlamova; S. O. Movsesyan; I. A. Arkhipov; S. S. Khalikov; M. V. Arisov; P. P. Kochetkov; V. E. Abramov; M. M. Il’in; B. V. Lokshin
Source:
Biology bulletin of the Russian Academy of Sciences 2020 v.47 no.6 pp. 549-558
ISSN:
1062-3590
Subject:
Trichinella spiralis; absorption; active ingredients; bioactive properties; blood; blood flow; fenbendazole; licorice; mechanochemistry; metabolites; models; oral administration; particle size; pharmacokinetics; sheep; sodium; solubility
Abstract:
... A supramolecular complex (SFBZ) of fenbendazole (FBZ) with licorice extract and sodium dioctyl sulfosuccinate is prepared by mechanochemical method, and its anthelminthic activity and metabolism in sheep are studied. Physicochemical studies of SFBZ confirmed its improved solubility and a decrease in the particle size. FBZ and its metabolites are found to display enhanced absorption into the bloods ...
DOI:
10.1134/S1062359020060138

86. Biologically guided isolation and ADMET profile of new factor Xa inhibitors from Glycyrrhiza glabra roots using in vitro and in silico approaches

Author:
Reham S. Ibrahim; Rahma S. R. Mahrous; Rasha M. Abu EL-Khair; Samir A. Ross; Abdallah A. Omar; Hoda M. Fathy
Source:
RSC advances 2021 v.11 no.17 pp. 9995-10001
ISSN:
2046-2069
Subject:
COVID-19 infection; Glycyrrhiza glabra; coagulation; computer simulation; formononetin; licorice; naringenin; root extracts; therapeutics
Abstract:
... Selective factor Xa inhibitors effectively block coagulation cascade with a broader therapeutic window than multitargeted anticoagulants. They have evolved as a crucial part of prevention and treatment of thromboembolic diseases and in therapeutic protocols involved in many clinical trials in coronavirus disease 2019 (COVID-19) patients. Biologically-guided isolation of specific FXa inhibitors fro ...
DOI:
10.1039/d1ra00359c

87. Biomarkers of food intake for cocoa and liquorice (products): a systematic review

Author:
Charlotte C. J. R. Michielsen; Enrique Almanza-Aguilera; Elske M. Brouwer-Brolsma; Mireia Urpi-Sarda; Lydia A. Afman
Source:
Genes & nutrition 2018 v.13 no.1 pp. 22
ISSN:
1555-8932
Subject:
biomarkers; caffeine; databases; dietary exposure; epidemiological studies; food frequency questionnaires; food intake; humans; licorice; metabolites; metabolome; polyphenols; sweets; systematic review; tea
Abstract:
... BACKGROUND: To unravel true links between diet and health, it is important that dietary exposure is accurately measured. Currently, mainly self-reporting methods (e.g. food frequency questionnaires and 24-h recalls) are used to assess food intake in epidemiological studies. However, these traditional instruments are subjective measures and contain well-known biases. Especially, estimating the inta ...
DOI:
10.1186/s12263-018-0610-x
PubMed:
30065791
PubMed Central:
PMC6062926

88. Biosynthesis-Based Quantitative Analysis of 151 Secondary Metabolites of Licorice To Differentiate Medicinal Glycyrrhiza Species and Their Hybrids

Author:
Song Wei; Qiao Xue; Chen Kuan; Wang Ying; Ji Shuai; Feng Jin; Li Kai; Lin Yan; Ye Min
Source:
Analytical chemistry 2017 v.89 no.5 pp. 3146-3153
ISSN:
1520-6882
Subject:
DNA barcoding; Glycyrrhiza; bioactive compounds; biochemical pathways; biosynthesis; chalcones; chemotypes; coumarins; females; flavonols; herbal medicines; homozygosity; hybridization; hybrids; internal transcribed spacers; licorice; males; medicinal plants; metabolomics; phenolic compounds; progeny; quality control; quantitative analysis; saponins; secondary metabolites; transcription (genetics)
Abstract:
... Secondary metabolites are usually the bioactive components of medicinal plants. The difference in the secondary metabolisms of closely related plant species and their hybrids has rarely been addressed. In this study, we conducted a holistic secondary metabolomics analysis of three medicinal Glycyrrhiza species (G. uralensis, G. glabra, and G. inflata), which are used as the popular herbal medicine ...
DOI:
10.1021/acs.analchem.6b04919

89. Biotechnological aspects of the production of natural sweetener glycyrrhizin from Glycyrrhiza sp.

Author:
Devendra Kumar Pandey; N. W. Ayangla
Source:
Phytochemistry reviews 2018 v.17 no.2 pp. 397-430
ISSN:
1568-7767
Subject:
Glycyrrhiza glabra; biotechnology; capillary electrophoresis; chromosome mapping; countercurrent chromatography; genes; genetic improvement; genetic markers; genetic relationships; genetic variation; glycyrrhizin; herbal medicines; high performance liquid chromatography; humans; ingredients; licorice; roots; stolons; sweetness; thin layer chromatography; tissue culture; ultraviolet-visible spectroscopy
Abstract:
... Biotechnology as a frontline technology has been maneuvered in a myriad of ways on Glycyrrhiza glabra that has directly or indirectly benefited the mankind. The roots and stolons of licorice species have long been used worldwide as a herbal medicine and natural sweetener. The main ingredient responsible for sweetness is glycyrrhizin which is used as sweetener agent in many herbal and commercial pr ...
DOI:
10.1007/s11101-017-9540-2

90. Boiling Licorice Produces Self-Assembled Protein Nanoparticles: A Novel Source of Bioactive Nanomaterials

Author:
Jianwu Zhou; Jian Zhang; Guanzhen Gao; Huiqin Wang; Xiaoyan He; Tianbao Chen; Lijing Ke; Pingfan Rao; Qiang Wang
Source:
Journal of agricultural and food chemistry 2019 v.67 no.33 pp. 9354-9361
ISSN:
1520-5118
Subject:
Glycyrrhiza uralensis; Oriental traditional medicine; astragalosides; boiling; buffers; cytotoxicity; drugs; encapsulation; hepatocytes; human cell lines; ingredients; licorice; molecular weight; nanoparticles; pH; proteins; prototypes; rhizomes; solubilization; zeta potential
Abstract:
... As a popular ingredient for western and traditional Chinese medicine, the root and rhizome of Chinese licorice (Glycyrrhiza uralensis Fisch.) is often administered in the form of a decoction. The protein nanoparticles (NPs) self-assembled during the process of decoction. A major constitutive protein (GLP) was purified and determined to have a molecular weight of 28 kDa with an N-terminal sequence ...
DOI:
10.1021/acs.jafc.9b03208

91. Bone health nutraceuticals alter microarray mRNA gene expression: A randomized, parallel, open-label clinical study

Author:
Yumei Lin; Valentina Kazlova; Shyam Ramakrishnan; Mary A. Murray; David Fast; Amitabh Chandra; Kevin W. Gellenbeck
Source:
Phytomedicine 2016 v.23 no.1 pp. 18-26
ISSN:
0944-7113
Subject:
Dimorphandra; Glycyrrhiza glabra; Punica granatum; Vitis vinifera; blood; blood sampling; bone density; bone formation; bone morphogenetic proteins; bone resorption; cathepsin G; collagen; extracellular matrix; food intake; fruits; functional foods; gene expression; gene expression regulation; genes; grape seeds; heparan sulfate; hyaluronoglucosaminidase; licorice; messenger RNA; microarray technology; osteoblasts; plant extracts; polyphenols; pomegranates; postmenopause; proteoglycans; quercetin; vegetables; women
Abstract:
... Dietary intake of fruits and vegetables has been suggested to have a role in promoting bone health. More specifically, the polyphenols they contain have been linked to physiological effects related to bone mineral density and bone metabolism. In this research, we use standard microarray analyses of peripheral whole blood from post-menopausal women treated with two fixed combinations of plant extra ...
DOI:
10.1016/j.phymed.2015.11.011

92. Boosting 11-oxo-β-amyrin and glycyrrhetinic acid synthesis in Saccharomyces cerevisiae via pairing novel oxidation and reduction system from legume plants

Author:
Ming Zhu; Caixia Wang; Wentao Sun; Anqi Zhou; Ying Wang; Genlin Zhang; Xiaohong Zhou; Yixin Huo; Chun Li
Source:
Metabolic engineering 2018 v.45 pp. 43-50
ISSN:
1096-7176
Subject:
Saccharomyces cerevisiae; cytochrome P-450; legumes; licorice; medicinal plants; oxidation; roots; screening; soil ecosystems; transcriptome; triterpenoids
Abstract:
... Glycyrrhetinic acid (GA) and its precursor, 11-oxo-β-amyrin, are typical triterpenoids found in the roots of licorice, a traditional Chinese medicinal herb that exhibits diverse functions and physiological effects. In this study, we developed a novel and highly efficient pathway for the synthesis of GA and 11-oxo-β-amyrin in Saccharomyces cerevisiae by introducing efficient cytochrome P450s (CYP45 ...
DOI:
10.1016/j.ymben.2017.11.009

93. CYP716A179 functions as a triterpene C-28 oxidase in tissue-cultured stolons of Glycyrrhiza uralensis

Author:
Keita Tamura; Hikaru Seki; Hideyuki Suzuki; Mareshige Kojoma; Kazuki Saito; Toshiya Muranaka
Source:
Plant cell reports 2017 v.36 no.3 pp. 437-445
ISSN:
0721-7714
Subject:
Glycyrrhiza uralensis; betulinic acid; biosynthesis; cytochrome P-450; engineering; genetically engineered microorganisms; glycyrrhizin; heterologous gene expression; licorice; lupeol; oleanolic acid; roots; sequence analysis; stolons; tissue culture; ursolic acid
Abstract:
... KEY MESSAGE : CYP716A179, a cytochrome P450 monooxygenase expressed predominantly in tissue-cultured stolons of licorice (Glycyrrhiza uralensis), functions as a triterpene C-28 oxidase in the biosynthesis of oleanolic acid and betulinic acid. Cytochrome P450 monooxygenases (P450s) play key roles in the structural diversification of plant triterpenoids. Among these, the CYP716A subfamily, which fun ...
DOI:
10.1007/s00299-016-2092-x

94. Can licorice root extract be used as an effective natural biostimulant for salt-stressed common bean plants?

Author:
M.M. Rady; E.-S.M. Desoky; A.S. Elrys; M.S. Boghdady
Source:
South African journal of botany 2019 v.121 pp. 294-305
ISSN:
0254-6299
Subject:
Phaseolus vulgaris; antioxidant activity; beans; chlorophyll; electrolytes; field experimentation; foliar spraying; hydrogen peroxide; licorice; malondialdehyde; nutrients; photosynthesis; pigments; plant growth; proline; roots; saline soils; salt stress; selenium; soaking; sodium; sugars; superoxide anion; water content
Abstract:
... Green approaches for promoting plant performance using natural supplementations are highly requested. After a field preliminary study was carried out in 2015 on saline (EC = 7.2 dS m−1) and normal (EC = 1.2 dS m−1) soils, two field trials were conducted to evaluate the potential effects of licorice root extract; LRE (0.5%; 5 g roots L−1 distilled water), used as seed soaking (SS) and/or foliar spr ...
DOI:
10.1016/j.sajb.2018.11.019

95. Can liquorice extract and herbal solution prevent colonic mucosa damage caused by robenacoxib in dogs?

Author:
M. Szweda; J. Szarek; M. Lew; A. Szarek-Bęska; D. Gulda
Source:
Polish journal of veterinary sciences 2016 v.18 no.4 pp. 793-798
ISSN:
2300-2557
Subject:
Beagle; biopsy; colon; dogs; endoscopy; females; licorice; males; mucosa; nonsteroidal anti-inflammatory agents; pain
Abstract:
... Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used in animals, especially in dogs, to manage pain due to inflammatory disease. This study investigated whether plant drugs can prevent mucosal injury induced by robenacoxib. We used fifteen healthy beagle dogs (7 male and 8 female) aged 4 months, weighing 4.2-5.1 kg at the beginning of the study. Endoscopy and biopsy of the colon were p ...
DOI:
10.1515/pjvs-2015-0103

96. Cancer Cell Signaling Pathways Targeted by Spice-Derived Nutraceuticals

Author:
Bokyung Sung; Sahdeo Prasad; Vivek R. Yadav; Bharat B. Aggarwal
Source:
Nutrition and cancer 2012 v.64 no.2 pp. 173-197
ISSN:
1532-7914
Subject:
Nigella sativa; acetates; anise; capsaicin; cardamom; chronic diseases; color; curcumin; diosgenin; eugenol; fenugreek; functional foods; genes; ginger; growth factors; licorice; protein kinases; rosemary; signal transduction; taste; transcription factors; turmeric; ursolic acid
Abstract:
... Extensive research within the last half a century has revealed that cancer is caused by dysregulation of as many as 500 different gene products. Most natural products target multiple gene products and thus are ideally suited for prevention and treatment of various chronic diseases, including cancer. Dietary agents such as spices have been used extensively in the Eastern world for a variety of ailm ...
DOI:
10.1080/01635581.2012.630551
PubMed:
22149093
PubMed Central:
PMC3645308

97. Capturing food-elicited emotions: Facial decoding of children’s implicit and explicit responses to tasted samples

Author:
Martina Galler; Åse Riseng Grendstad; Gastón Ares; Paula Varela
Source:
Food quality and preference 2022 v.99 pp. 104551
ISSN:
0950-3293
Subject:
Mentha piperita nothosubsp. piperita; algorithms; case studies; chocolate milk; computer software; fearfulness; flavor; food quality; licorice; observational studies; prediction
Abstract:
... Sensory and consumer research increasingly aims to gain direct input from children to study their eating behaviour. However, answering self-administered questionnaires can be challenging for children. In this sense, the prediction of basic emotions via facial decoding, generating quantitative observational data, could offer an alternative to questionnaires. The present study aimed to measure child ...
DOI:
10.1016/j.foodqual.2022.104551

98. Catalytic pyrolysis of liquorice (Glycyrrhiza glabra L.) in a fixed-bed reactor: Effects of pyrolysis parameters on product yields and character

Author:
Tevfik Aysu; Halil Durak
Source:
Journal of analytical and applied pyrolysis 2015 v.111 pp. 156-172
ISSN:
0165-2370
Subject:
Glycyrrhiza glabra; aluminum oxide; biochar; biofuels; catalysts; ferric chloride; gas chromatography-mass spectrometry; licorice; liquids; potassium carbonate; pyrolysis; temperature; zinc oxide
Abstract:
... Pyrolysis of liquorice (Glycyrrhiza glabra L.) stalks were performed in a fixed-bed tubular reactor with (ZnO, FeCl3, K2CO3, Al2O3, Na2B4O7·10H2O) and without catalyst at three different temperatures (350, 450, 550°C) with a constant heating rate of 40°C/min. The amounts of bio-char, bio-oil and gas produced, as well as the compositions of the resulting bio-oils were determined by GC–MS. The effec ...
DOI:
10.1016/j.jaap.2014.11.017

99. Change in the active component of processed Tetradium ruticarpum extracts leads to improvement in efficacy and toxicity attenuation

Author:
Qiyuan Shan; Gang Tian; Juli Wang; Hui Hui; Qiyang Shou; Huiying Fu; Min Hao; Kuilong Wang; Xin Wu; Gang Cao; Guanqun Chen; Luping Qin
Source:
Journal of ethnopharmacology 2021 v.264 pp. 113292
ISSN:
0378-8741
Subject:
Oriental traditional medicine; Tetradium ruticarpum; acute toxicity; alkaloids; amides; analgesics; animal models; anti-inflammatory activity; bioactive compounds; coumarins; essential oils; ethanol; fruits; gas chromatography-mass spectrometry; indoles; licorice; limonoids; manufacturing; medicinal plants; mice; oils; plant extracts; quality control; quinolones; smell; stir frying; ultra-performance liquid chromatography; volatile compounds
Abstract:
... The dried and nearly ripe fruits of Tetradium ruticarpum (A. Juss.) T.G. Hartley (TR) have long been used in treating headache and gastrointestinal disorders in oriental medicine. TR is usually processed by stir-frying with licorice extract before use. Although processing procedure is considered as the way to relieve pungent smell, reduce toxicity, and improve efficacy, its effects on TR's toxicit ...
DOI:
10.1016/j.jep.2020.113292

100. Change of microbiotas of maize-based extruded products with vegetable additives during storage

Author:
O. Bunyak; S. Sots; A. Egorova; L. Valevskaya; G. Evdokimova
Source:
Harčova nauka ì tehnologìâ 2018 v.12 no.4 pp. -
ISSN:
2409-7004
Subject:
air; air temperature; ambient temperature; barley; cardboard; carrots; color; corn; diabetes; flavonoids; glucosides; humidity; licorice; odors; polypropylenes; shelf life; storage time; sugars; taste
Abstract:
... Recently, sugar maize has become more and more widely used for the production of new types of food. Its use in the production of cereal products for babies makes it possible to use no sugar in their composition, switch to the production of dietary and prophylactic products, which acquires high importance against the background of “rejuvenation” of diabetes and the manifestation of other nutritiona ...
DOI:
10.15673/fst.v12i4.1204