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1. (+)-Episesaminone, a Sesamum indicum furofuran lignan. Isolation and hemisynthesis

Author:
Marchand, P.A.; Kato, M.J.; Lewis, N.G.
Source:
Journal of natural products 1997 v.60 no.11 pp. 1189-1192
ISSN:
0163-3864
Subject:
Sesamum indicum; seeds; furans; lignans; spectral analysis; chemical structure; biosynthesis; biochemical pathways; chemical reactions; chemical constituents of plants
DOI:
10.1021/np9702953

2. (+)-Medioresinol leads to intracellular ROS accumulation and mitochondria-mediated apoptotic cell death in Candida albicans

Author:
Ji Hong Hwang; In-sok Hwang; Qing-He Liu; Eun-Rhan Woo; Dong Gun Lee
Source:
Biochimie 2012 v.94 no.8 pp. 1784-1793
ISSN:
0300-9084
Subject:
mitochondrial membrane; reactive oxygen species; medicinal plants; oxidative stress; mechanism of action; mitochondria; plasma membrane; apoptosis; antifungal properties; traditional medicine; Candida albicans; Sambucus; yeasts; lignans; bark; risk reduction; phosphatidylserines; DNA fragmentation; cardiovascular diseases; cytochrome c; cell cycle
Abstract:
... The phytochemical (+)-Medioresinol, a furofuran type lignan identification and isolation on the stem bark of Sambucus williamsii, which is a folk medicinal plant used in traditional medicine. (+)-Medioresinol is known to possess a lesishmanicidal activity and cardiovascular disease risk reduction but its antifungal effects have not yet been identified. In this study, to confirm (+)-Medioresinol's ...
DOI:
10.1016/j.biochi.2012.04.010

3. (+)-Sesamin attenuates chronic unpredictable mild stress-induced depressive-like behaviors and memory deficits via suppression of neuroinflammation

Author:
Yihang Zhao; Qianxu Wang; Mengzhen Jia; Shangchen Fu; Junru Pan; Chuanqi Chu; Xiaoning Liu; Xuebo Liu; Zhigang Liu
Source:
Journal of nutritional biochemistry 2019 v.64 pp. 61-71
ISSN:
0955-2863
Subject:
animal models; antidepressants; anxiety; blood serum; cognition; cognitive disorders; cortex; food composition; forced swimming test; hippocampus; inducible nitric oxide synthase; interleukin-1beta; lignans; memory disorders; mice; neuroglia; neurons; neurotrophins; serotonin; synapse; tail suspension test; therapeutics; tumor necrosis factor-alpha; ultrastructure
Abstract:
... Depression is a mood disorder that is related to neuroinflammation and cognition loss. This study is aimed to determine the potential antidepressant effects of (+)-sesamin, a lignan component of sesame, in a mild stress-induced depression mouse model. CD-1 mice were treated with chronic unpredictable mild stress (CUMS) process and orally administrated with sesamin (50 mg/kg/d) for 6 weeks. Behavio ...
DOI:
10.1016/j.jnutbio.2018.10.006

4. (+)-Sesamin, a sesame lignan, is a potent inhibitor of gut bacterial tryptophan indole-lyase that is a key enzyme in chronic kidney disease pathogenesis

Author:
Daiki Oikawa; Satoshi Yamashita; Seiji Takahashi; Toshiyuki Waki; Koichi Kikuchi; Takaaki Abe; Takane Katayama; Toru Nakayama
Source:
Biochemical and biophysical research communications 2022 v.590 pp. 158-162
ISSN:
0006-291X
Subject:
Escherichia coli; active sites; dietary supplements; enzymes; intestines; kidney diseases; kidneys; lignans; mice; morbidity; pathogenesis; phytochemicals; pyridoxal; research; sulfates; therapeutics; toxins; tryptophan
Abstract:
... The progression of chronic kidney disease (CKD) increases the risks of cardiovascular morbidity and end-stage kidney disease. Indoxyl sulfate (IS), which is derived from dietary l-tryptophan by the action of bacterial l-tryptophan indole-lyase (TIL) in the gut, serves as a uremic toxin that exacerbates CKD-related kidney disorder. A mouse model previously showed that inhibition of TIL by 2-aza-l-t ...
DOI:
10.1016/j.bbrc.2021.12.088

5. (+)‐Sesamin‐oxidising CYP92B14 shapes specialised lignan metabolism in sesame

Author:
Erisa Harada; Jun Murata; Eiichiro Ono; Hiromi Toyonaga; Akira Shiraishi; Kosuke Hideshima; Masayuki P. Yamamoto; Manabu Horikawa
Source:
plant journal 2020 v.104 no.4 pp. 1117-1128
ISSN:
0960-7412
Subject:
Sesamum indicum; amino acid substitution; constitutional isomers; coproducts; enzymes; heme; lignans; metabolism; oxidation; propionic acid
Abstract:
... Sesamum spp. (sesame) are known to accumulate a variety of lignans in a lineage‐specific manner. In cultivated sesame (Sesamum indicum), (+)‐sesamin, (+)‐sesamolin and (+)‐sesaminol triglucoside are the three major lignans found richly in the seeds. A recent study demonstrated that SiCYP92B14 is a pivotal enzyme that allocates the substrate (+)‐sesamin to two products, (+)‐sesamolin and (+)‐sesami ...
DOI:
10.1111/tpj.14989

6. (-)-7(S)-hydroxymatairesinol protects against tumor necrosis factor-α-mediated inflammation response in endothelial cells by blocking the MAPK/NF-κB and activating Nrf2/HO-1

Author:
Di Yang; Chen-Xi Xiao; Zheng-Hua Su; Meng-Wei Huang; Ming Qin; Wei-Jun Wu; Wan-Wan Jia; Yi-Zhun Zhu; Jin-Feng Hu; Xin-Hua Liu
Source:
Phytomedicine 2017 v.32 pp. 15-23
ISSN:
0944-7113
Subject:
Western blotting; anti-inflammatory activity; antineoplastic activity; antioxidants; cardiovascular diseases; drugs; endothelial cells; fluorescent antibody technique; gene expression regulation; heme oxygenase (biliverdin-producing); inducible nitric oxide synthase; inflammation; interleukin-6; lignans; messenger RNA; mitogen-activated protein kinase; necrosis; pathogenesis; phosphorylation; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; signal transduction; superoxide dismutase; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:
... Endothelial inflammation is an increasingly prevalent condition in the pathogenesis of many cardiovascular diseases. (-)-7(S)-hydroxymatairesinol (7-HMR), a naturally occurring plant lignan, possesses both antioxidant and anti-cancer properties and therefore would be a good strategy to suppress tumor necrosis factor-α (TNF-α)-mediated inflammation in vascular endothelial cells (VECs).: The objecti ...
DOI:
10.1016/j.phymed.2017.04.005

7. (-)-Asarinin inhibits mast cells activation as a Src family kinase inhibitor

Author:
Yajing Hou; Tian Hu; Di Wei; Jiapan Gao; Delu Che; Xiangjun Wang; Cheng Wang; Huaizhen He
Source:
international journal of biochemistry & cell biology 2020 v.121 pp. 105701
ISSN:
1357-2725
Subject:
allergic rhinitis; anaphylaxis; animal models; anti-allergic agents; calcium; histamine; humans; interleukin-4; lignans; mast cells; mechanism of action; nasal mucosa; phosphorylation; phosphotransferases (kinases); public health; secretion
Abstract:
... As one of the major global health issues, allergic disease represents a considerable burden both on individual patients and public health. (-)-Asarinin (Asa), a lignan isolated from the roots of Asiasari radix, was reported to be associated with anti-allergic effect, but its efficacy and mechanism of action remain unclear. This study investigated the inhibitory effect of Asa on allergic reaction a ...
DOI:
10.1016/j.biocel.2020.105701

8. (-)-Hinokinin causes antigenotoxicity but not genotoxicity in peripheral blood of Wistar rats

Author:
Medola, J.F.; Cintra, V.P.; Silva, E.P.P. e; Royo, V. de A.; Silva, R. da; Saraiva, J.; Albuquerque, S.; Bastos, J.K.; Silva, M.L.A. e; Tavares, D.C.
Source:
Food and chemical toxicology 2007 v.45 no.4 pp. 638-642
ISSN:
0278-6915
Subject:
Piper cubeba; reticulocytes; seed extracts; DNA damage; seeds; antimutagenic activity; hydrogen peroxide; essential oils; chromosome aberrations; lignans; DNA repair; animal models; genotoxicity; antioxidant activity; drying; rats
DOI:
10.1016/j.fct.2006.10.012
PubMed:
17141387

9. (-)-Syringaresinol-4-O-β-D-glucopyranoside from Cortex Albizziae inhibits corticosterone-induced PC12 cell apoptosis and relieves the associated dysfunction

Author:
Desen Yang; Wanqin Wu; Guoping Gan; Dingkun Wang; Jing Gong; Ke Fang; Fuer Lu
Source:
Food and chemical toxicology 2020 v.141 pp. 111394
ISSN:
0278-6915
Subject:
Western blotting; anxiety; apoptosis; binding proteins; calcium; caspase-3; cell proliferation; cell viability; cortex; corticosterone; cytochrome c; enzyme activity; flow cytometry; glycosides; lactate dehydrogenase; lignans; membrane potential; mitochondria; mitochondrial membrane; models; neuroprotective effect; pathogenesis; propidium; protein synthesis; rhodamines; staining; toxicology
Abstract:
... The neuroprotective effects and potential mechanisms of (-)-Syringaresinol-4-O-β-D-glucopyranoside (SRG), a natural lignan glycoside extracted from Cortex Albizziae, were investigated using corticosterone (CORT)-induced PC12 cells as an in vitro anxiety model. PC12 cells were treated with 100 μM CORT and 5, 10, or 20 μM SRG for 48 h. Cell viability and lactate dehydrogenase (LDH) leakage were meas ...
DOI:
10.1016/j.fct.2020.111394

10. (7R,8S)-9-Acetyl-dehydrodiconiferyl alcohol inhibits inflammation and migration in lipopolysaccharide-stimulated macrophages

Author:
Li-Long Pan; Qiu-Yang Zhang; Xiao-Ling Luo; Juan Xiong; Peng Xu; Si-Yu Liu; Jin-Feng Hu; Xin-Hua Liu
Source:
Phytomedicine 2016 v.23 no.5 pp. 541-549
ISSN:
0944-7113
Subject:
Clematis; Western blotting; alcohols; anti-inflammatory activity; cell movement; chemotaxis; inducible nitric oxide synthase; inflammation; lignans; lipopolysaccharides; macrophages; mitogen-activated protein kinase; nitric oxide; non-specific protein-tyrosine kinase; non-specific serine/threonine protein kinase; phosphorylation; prostaglandin synthase; stems; transcription factor NF-kappa B; viability
Abstract:
... (7R, 8S)-9-Acetyl-dehydrodiconiferyl alcohol (ADDA), a novel lignan compound isolated from Clematis armandii Franch (Ranunculaceae) stems, has been found to exert potential anti-inflammatory activities in vitro.To investigate the pharmacological effects and molecular mechanisms of ADDA on lipopolysaccharide (LPS)-induced activation and migration of macrophages.Macrophages were stimulated with LPS ...
DOI:
10.1016/j.phymed.2016.02.018

11. (Poly)phenolic characterization of three food supplements containing 36 different fruits, vegetables and berries

Author:
Letizia Bresciani; Luca Calani; Marta Cossu; Pedro Mena; Marietta Sayegh; Sumantra Ray; Daniele Del Rio
Source:
PharmaNutrition 2015 v.3 no.2 pp. 11-19
ISSN:
2213-4344
Subject:
anthocyanins; bioactive compounds; coumaric acids; dietary supplements; flavanols; flavanones; flavonols; food plants; fruits; lignans; plant-based foods; proanthocyanidins; small fruits; vegetables
Abstract:
... There is continuously accruing evidence to suggest the health benefits of consuming fruits and vegetables. Food supplements may represent an effective and acceptable method to deliver a way of providing bioactive compounds to consumers. The aim of this work was to characterize the (poly)phenolic composition of three plant-based food supplements designed to integrate and increase the daily intake o ...
DOI:
10.1016/j.phanu.2015.01.001

12. (±)-Acortatarinowins A–F, Norlignan, Neolignan, and Lignan Enantiomers from Acorus tatarinowii

Author:
Lu Yuanyuan; Xue Yongbo; Liu Junjun; Yao Guangmin; Li Dongyan; Sun Bin; Zhang Jinwen; Liu Yanfei; Qi Changxing; Xiang Ming; Luo Zengwei; Du Guang; Zhang Yonghui
Source:
Journal of natural products 2015 v.78 no.9 pp. 2205-2214
ISSN:
1520-6025
Subject:
Acorus gramineus; X-ray diffraction; circular dichroism spectroscopy; enantiomers; high performance liquid chromatography; inhibitory concentration 50; lignans; macrophages; nitric oxide; rhizomes
Abstract:
... Three pairs of new 8-O-4′-type dinorneolignan enantiomers, (±)-acortatarinowins A–C (1a/1b–3a/3b), a pair of new 8-O-4′-type (4a/4b) and a pair of rare C7–C8′-type (5a/5b) neolignan enantiomers, (±)-acortatarinowins D and E, and a pair of new furofuran-type lignan enantiomers, (±)-acortatarinowin F (6a/6b), along with two pairs of known lignan enantiomers (7a/7b and 8a/8b), were obtained from the ...
DOI:
10.1021/acs.jnatprod.5b00328

13. (±)-Licarin A and its semi-synthetic derivatives: In vitro and in silico evaluation of trypanocidal and schistosomicidal activities

Author:
Vanderlisa Rita Meleti; Viviane Rodrigues Esperandim; Luzio Gabriel Bocalon Flauzino; Anna Helena Prizantelli; Lucas Antônio de Lima Paula; Lizandra Guidi Magalhães; Wilson Roberto Cunha; Rosângela da Silva Laurentiz; Ana Paula da Rocha Pissurno; N.P. Dhammika Nanayakkara; Ana Carolina Pereira; Jairo Kenupp Bastos; Renato Luis Tâme Parreira; Renato Pereira Orenha; Márcio Luis Andrade e Silva
Source:
Acta tropica 2020 v.202 pp. 105248
ISSN:
0001-706X
Subject:
Chagas disease; Schistosoma mansoni; Trypanosoma cruzi; adults; carbon; computer simulation; etiological agents; in vitro studies; lignans; methylation; mortality; nuclear magnetic resonance spectroscopy; peroxidase; schistosomiasis; stable isotopes; viability
Abstract:
... This paper reports the synthesis of (±)-licarin A 1, a dihydrobenzofuran neolignan, resultant of an oxidative coupling reaction of isoeugenol and horseradish peroxidase (HRP) enzyme. Following, three semi-synthetic derivatives from this compound were obtained: benzylated (±)-licarin A 2, methylated (±)-licarin A 3 and acetylated (±)-licarin A 4. After structural elucidation and assignment by Nucle ...
DOI:
10.1016/j.actatropica.2019.105248

14. (±)-Torreyunlignans A–D, Rare 8–9′ Linked Neolignan Enantiomers as Phosphodiesterase-9A Inhibitors from Torreya yunnanensis

Author:
Cheng Zhong-Bin; Lu Xiao; Bao Jing-Mei; Han Qing-Hua; Dong Zhen; Tang Gui-Hua; Gan Li-She; Luo Hai-Bin; Yin Sheng
Source:
Journal of natural products 2014 v.77 no.12 pp. 2651-2657
ISSN:
1520-6025
Subject:
Alzheimer disease; Torreya; adenosine; diabetes; enantiomers; inhibitory concentration 50; lignans; spectroscopy; tritium
Abstract:
... (±)-Torreyunlignans A–D (1a/1b–4a/4b), four pairs of new 8–9′ linked neolignan enantiomers featuring a rare (E)-2-styryl-1,3-dioxane moiety, were isolated from the trunk of Torreya yunnanensis. The structures were determined by combined spectroscopic and chemical methods, and the absolute configurations were elucidated by ECD calculations. The compounds were screened by using tritium-labeled adeno ...
DOI:
10.1021/np500528u

15. (−)-Olivil and (+)-1-Acetoxypinoresinol from the Olive Tree (Olea europaea LINNE; Oleaceae) as Feeding Stimulants of the Olive Weevil (Dyscerus perforatus)

Author:
Emiko KADOWAKI; Yasuhiro YOSHIDA; Teruhiko NITODA; Naomichi BABA; Shuhei NAKAJIMA
Source:
Bioscience, biotechnology, and biochemistry 2003 v.67 no.2 pp. 415-419
ISSN:
1347-6947
Subject:
Curculionidae; Olea europaea; biochemistry; biotechnology; females; lignans; males; olives; spectral analysis; surveys
Abstract:
... Guided by a feeding stimulant activity test on the olive weevil (Dyscerus perforatus), two compounds that showed potent feeding stimulant activity were isolated from the olive tree (Olea europaea). Based on their spectral data and a literature survey, they were identified as (−)-olivil (1) and (+)-1-acetoxypinoresinol (2). The activities of these minor lignans were significantly higher for the fem ...
DOI:
10.1271/bbb.67.415

16. (−)-Secoisolariciresinol attenuates high-fat diet-induced obesity in C57BL/6 mice

Author:
Shiori Tominaga; Kosuke Nishi; Sogo Nishimoto; Koichi Akiyama; Satoshi Yamauchi; Takuya Sugahara
Source:
Food & function 2012 v.3 no.1 pp. 76-82
ISSN:
2042-650X
Subject:
acyl-CoA oxidase; adipocytes; adiponectin; beta oxidation; blood serum; carnitine; fatty acids; fatty-acid synthase; gene expression; genes; high fat diet; lactones; leptin; lignans; linseed; liver; males; mice; obesity; oral administration; peroxisome proliferator-activated receptor alpha; stereoisomers; sterols; subcutaneous injection
Abstract:
... Flaxseed lignan, secoisolariciresinol has been reported to possess health benefits. We previously synthesized each stereoisomer of secoisolariciresinol and found that (−)-secoisolariciresinol reduces lipid accumulation and induces adiponectin production in 3T3-L1 adipocytes. Here we show the effects of (−)-secoisolariciresinol on high-fat diet-induced obesity in C57BL/6 male mice. Oral administrat ...
DOI:
10.1039/c1fo10166h

17. 1,4-Benzodioxane Lignans: An Efficient, Asymmetric Synthesis of Flavonolignans and Study of Neolignan Cytotoxicity and Antiviral Profiles

Author:
Lisa I. Pilkington; Jessica Wagoner; Toni Kline; Stephen J. Polyak; David Barker
Source:
Journal of natural products 2018 v.81 no.12 pp. 2630-2637
ISSN:
1520-6025
Subject:
alcohols; antiviral properties; bioactive compounds; cytotoxicity; dioxane; lignans; moieties
Abstract:
... 1,4-Benzodioxane lignans are a class of bioactive compounds that have received much attention through the years. Herein research pertaining to both 1,4-benzodioxane flavonolignans and 1,4-benzodioxane neolignans is presented. A novel synthesis of both traditional 1,4-benzodioxane flavonolignans and 3-deoxyflavonolignans is described. The antiviral and cytotoxic activities of 1,4-benzodioxane neoli ...
DOI:
10.1021/acs.jnatprod.8b00416

18. 10-Demethoxystegane, a new lignan from Steganotaenia araliacea

Author:
Meragelman, K.M.; McKee, T.C.; Boyd, M.R.
Source:
Journal of natural products 2001 v.64 no.11 pp. 1480-1482
ISSN:
0163-3864
Subject:
Apiaceae; lignans; lactones; spectral analysis; chemical structure; antineoplastic agents; humans; ovarian diseases; chemical constituents of plants; Tanzania
DOI:
10.1021/np010248h
PubMed:
11720541

19. 11-Methoxyviburtinal, a new iridoid fromValeriana jatamansi

Author:
Ye-Gao Chen; Li-Li Yu; Rong Huang; Yu-Ping Lv; Shi-Hong Gui
Source:
Archives of pharmacal research 2005 v.28 no.10 pp. 1161-1163
ISSN:
0253-6269
Subject:
Valeriana jatamansi; chromatography; glycosides; iridoids; lignans; roots; spectroscopy
Abstract:
... Five compounds of iridoids, lignan and phenylpropanoid glycosides were isolated from the roots ofValeriana jatamansi by column chromatography. Their structures were elucidated as 11-methoxyviburtinal (1), baldrinal (2), prinsepiol-4-O-β-D-glucoside (3), coniferin (4), and hexacosanic acid (5) by spectroscopic analysis. 11-Methoxyviburtinal was a new compound, and others were isolated from the plan ...
DOI:
10.1007/BF02972980

20. 13C NMR spectra of arylnaphthalene lignans

Author:
Abdullaev, N.D.; Yagudaev, M.R.; Batirov, E.Kh.; Malikov, V.M.
Source:
Chemistry of natural compounds 1987 v.23 no.1 pp. 63-74
ISSN:
0009-3130
Subject:
lignans; carbon; isotopes; nuclear magnetic resonance spectroscopy
DOI:
10.1007/BF00602461

21. 1H-Cyclopenta[b]benzofuran Lignans from Aglaia Species Inhibit Cell Proliferation and Alter Cell Cycle Distribution in Human Monocytic Leukemia Cell Lines

Author:
Frank I. Bohnenstengel; Klaus G. Steube; Corinna Meyer; Hilmar Quentmeier; Bambang W. Nugroho; Peter Proksch
Source:
Zeitschrift für Naturforschung 2014 v.54 no.12 pp. 1075-1083
ISSN:
1865-7125
Subject:
Aglaia; DNA; actinomycin D; active ingredients; cell cycle; cell growth; cell proliferation; cycloheximide; humans; lignans; methylation; neoplasm cells; protein synthesis; sulfates; thymidine; tritium; vinblastine; Vietnam
Abstract:
... Thirteen naturally occurring 1H-cyclopenta[b]benzofuran lignans of the rocaglamide type as well as one naturally occurring aglain congener all of them isolated from three Aglaia species (Aglaia duperreana, A. oligophylla and A. spectabilis) collected in Vietnam were studied for their antiproliferative effects using the human monocytic leukemia cell lines MONO-MAC-1 and MONO-MAC-6. Only rocaglamide ...
DOI:
10.1515/znc-1999-1212

22. 2,2'-diphenyl-1-picrylhydrazyl radical-scavenging active components from adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) hulls

Author:
Kuo, C.C.; Chiang, W.; Liu, G.P.; Chien, Y.L.; Chang, J.Y.; Lee, C.K.; Lo, J.M.; Huang, S.L.; Shih, M.C.; Kuo, Y.H.
Source:
Journal of agricultural and food chemistry 2002 v.50 no.21 pp. 5850-5855
ISSN:
0021-8561
Subject:
coniferyl alcohol; free radicals; free radical scavengers; lignans; resinols; oxidation; antioxidant activity; syringic acid; ferulic acid; hulls
Abstract:
... An activity-directed fractionation and purification process was used to identify the antioxidative components of adlay hulls. Hulls of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) were extracted with methanol and then separated into water, 1-butanol, ethyl acetate, and hexane fractions. The 1-butanol-soluble fraction exhibited greater capacity to scavenge 2,2'-diphenyl-1-picrylhydrazyl (DPPH) ...
DOI:
10.1021/jf020391w
PubMed:
12358449

23. 2-Aminobenzoyl and megastigmane glycosides from Wrightia antidysenterica

Author:
Chutima Srinroch; Poolsak Sahakitpichan; Supanna Techasakul; Nitirat Chimnoi; Somsak Ruchirawat; Tripetch Kanchanapoom
Source:
Phytochemistry letters 2019 v.29 pp. 61-64
ISSN:
1874-3900
Subject:
Wrightia; flavonoids; glycosides; lignans; nuclear magnetic resonance spectroscopy
Abstract:
... A new aminobenzoyl glycoside, 2-aminobenzoyl O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside (1) and two new megastigmane glycosides, wrightiaionosides A (10), and B (11), were isolated along with 17 known compounds, including four benzoxazinoid glycosides (2-5), one indole diglycoside (6), three simple aromatic glycosides (7-9), three megastigmane glycosides (12-14), five flavonoid glycosides (15-1 ...
DOI:
10.1016/j.phytol.2018.11.006

24. 3-O-β-ᴅ-Galactopyranoside of Quercetin as an Active Principle from High Altitude Podophyllum hexandrum and Evaluation of its Radioprotective Properties

Author:
Raman Chawla; Rajesh Arora; Ravinder K. Sagar; Shikha Singh; Satish C. Puri; Raj Kumara; Surender Singh; Ashok K. Sharma; Jagdish Prasad; Haider A. Khan; Rakesh Kumar Sharma; Kanaya Lal Dhar; Michael Spiteller; Ghulam Nabi Qazi
Source:
Zeitschrift für Naturforschung 2014 v.60 no.9-10 pp. 728-738
ISSN:
0939-5075
Subject:
DNA; Podophyllum hexandrum; acid hydrolysis; altitude; antioxidant activity; bovine serum albumin; brain; gamma radiation; iron; kidneys; lignans; linoleic acid; lipid peroxidation; liquid chromatography; mass spectrometry; models; nuclear magnetic resonance spectroscopy; quercetin; radioprotective effect
Abstract:
... The aqueous-ethanolic extract (AEE) of high altitude Podophyllum hexandrum has earlier been reported to render a radioprotective effect against lethal gamma radiation in in vitro model. AEE has also been reported to possess metal chelating and DNA protecting properties. The present study was undertaken to isolate and characterize the bioactive principle present in AEE and investigate its role in r ...
DOI:
10.1515/znc-2005-9-1012

25. 5-Methoxyhydnocarpin-D and pheophorbide: Berberis species components that potentiate berberine growth inhibition of resistant Staphylococcus aureus

Author:
Stermitz, F.R.; Tawara-Matsuda, J.; Lorenz, P.; Zenewicz, L.; Lewis, K.
Source:
Journal of natural products 2000 v.63 no.8 pp. 1146-1149
ISSN:
0163-3864
Subject:
Staphylococcus aureus; fractionation; alkaloids; chemical constituents of plants; multiple drug resistance; Mahonia aquifolium; flavonols; bioassays; lignans; Berberis; synergism; leaves; antibacterial properties; Colorado
DOI:
10.1021/np990639k

26. 5-Methoxyjusticidin A, a new arylnaphthalene lignan from Protium unifoliolatum

Author:
Siani, A.C.; Zoghbi, M. das G.B.; Wolter, E.L.A.; Vencato, I.
Source:
Journal of natural products 1998 v.61 no.6 pp. 796-797
ISSN:
0163-3864
Subject:
Burseraceae; medicinal plants; wood; naphthalene; lignans; spectral analysis; chemical structure; chemical constituents of plants; Brazil
DOI:
10.1021/np9702291
PubMed:
9644067

27. 5-Methyl ether flavone glucosides from the leaves of Bruguiera gymnorrhiza

Author:
Acharawan Panyadee; Poolsak Sahakitpichan; Somsak Ruchirawat; Tripetch Kanchanapoom
Source:
Phytochemistry letters 2015 v.11 pp. 215-219
ISSN:
1874-3900
Subject:
Bruguiera gymnorhiza; Cotoneaster; glucosides; kaempferol; leaves; lignans; luteolin; myricetin; nuclear magnetic resonance spectroscopy; quercetin; rutin; spectral analysis
Abstract:
... Two new 5-methyl ether flavone glucosides (7,4′,5′-trihydroxy-5,3′-dimethoxyflavone 7-O-β-D-glucopyranoside and 7,4′-dihydroxy-5-methoxyflavone 7-O-β-D-glucopyranoside) were isolated from the leaves of Thai mangrove Bruguiera gymnorrhiza together with 7,3′,4′,5′-tetrahydroxy-5-methoxyflavone, 7,4′,5′-trihydroxy-5,3′-dimethoxyflavone, luteolin 5-methyl ether 7-O-β-D-glucopyranoside, 7,4′-dihydroxy- ...
DOI:
10.1016/j.phytol.2014.12.021

28. 6-Methoxypodophyllotoxin-7-O-n-hexanoate, a new aryltetralin lignan ester from seeds of Linum flavum

Author:
Klaes, Michael; Ellendorff, Therese; Schmidt, Thomas J.
Source:
Planta medica 2010 v.76 no.7 pp. 719-721
ISSN:
0032-0943
Subject:
Linum flavum; seeds; chemical constituents of plants; lignans; esters; spectral analysis; chemical structure; plant extracts
DOI:
10.1055/s-0029-1240674
PubMed:
19960414

29. 6-O-benzoylgomisin O, a new lignan from the fruits of Schizandra chinensis

Author:
Chen, C.C.; Shen, C.C.; Shih, Y.Z.; Pan, T.M.
Source:
Journal of natural products 1994 v.57 no.8 pp. 1164-1165
ISSN:
0163-3864
Subject:
Schisandra chinensis; lignans; spectral analysis; chemical constituents of plants; molecular conformation
DOI:
10.1021/np50110a006

30. 7-Hydroxymatairesinol improves body weight, fat and sugar metabolism in C57BJ/6 mice on a high-fat diet

Author:
Giorgio Biasiotto; Isabella Zanella; Federica Predolini; Ivonne Archetti; Moris Cadei; Eugenio Monti; Marcello Luzzani; Barbara Pacchetti; Paola Mozzoni; Roberta Andreoli; Giuseppe De Palma; Federico Serana; Annika Smeds; Diego Di Lorenzo
Source:
British journal of nutrition 2018 v.120 no.7 pp. 751-762
ISSN:
1475-2662
Subject:
Picea abies; adipocytes; adipogenesis; blood lipids; cholesterol; dietary supplements; epididymis; foods; genes; hepatoma; high fat diet; insulin resistance; insulin secretion; lactones; lignans; liver; low density lipoprotein; males; metabolic syndrome; metabolism; metabolites; mice; models; obesity; oral administration; peroxisome proliferator-activated receptor gamma; sugars
Abstract:
... 7-Hydroxymatairesinol (7-HMR) is a plant lignan abundant in various concentrations in plant foods. The objective of this study was to test HMRLignan™, a purified form of 7-HMR, and the corresponding Picea abies extract (total extract P. abies; TEP) as dietary supplements on a background of a high-fat diet (HFD)-induced metabolic syndrome in mice and in the 3T3-L1 adipogenesis model. Mice, 3 weeks ...
DOI:
10.1017/S0007114518001824
PubMed:
30105962 30105962

31. 8-O-4′-Neolignans from the Stem Bark of Illicium difengpi and their ANTI-HIV-1 Activities

Author:
Yuchun Yang; Ying Qin; Yanlin Meng; Congfang Xia; Xuemei Gao; Qiufen Hu
Source:
Chemistry of natural compounds 2016 v.52 no.1 pp. 43-47
ISSN:
0009-3130
Subject:
Human immunodeficiency virus 1; Illicium; antiviral properties; bark; chemistry; lignans; nuclear magnetic resonance spectroscopy; spectral analysis
Abstract:
... Two new 8-O-4′-neolignans, difenneolignans A and B (1 and 2), together with six known neolignans (3–8), were isolated from the stem bark of Illicium difengpi. The structures of 1–8 were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were also tested for their anti-HIV-1 activities. The results revealed significant activities for compounds 1 and ...
DOI:
10.1007/s10600-016-1543-5

32. Abietane diterpenoids and other constituents from Clerodendrum trichotomum

Author:
Lin-zhen Li; Meng-hua Wang; Jian-bo Sun; Jing-yu Liang
Source:
Biochemical systematics and ecology 2014 v.56 pp. 218-220
ISSN:
0305-1978
Subject:
Clerodendrum trichotomum; Verbenaceae; anthraquinones; diterpenoids; lignans; phylogeny; stems
Abstract:
... The genus Clerodendrum Linn., originally belonging to Verbenaceae, was assigned to Lamiaceae by APG (Angiosperm Phylogeny Group) Ⅱ. Seven abietane diterpenoids (1–7) along with three anthraquinones (8–10) and one neolignan (11) were isolated and identified from the stems of Clerodendrum trichotomum Thunb.. Among them, compounds 4, 6 and 8–11 were reported from the genus Clerodendrum Linn. for the ...
DOI:
10.1016/j.bse.2014.06.002

33. Abscisic acid related compounds and lignans in prunes (Prunus domestica L.) and their oxygen radical absorbance capacity (ORAC)

Author:
Kikuzaki, H.; Kayano, S.; Fukutsuka, N.; Aoki, A.; Kasamatsu, K.; Yamasaki, Y.; Mitani, T.; Nakatani, N.
Source:
Journal of agricultural and food chemistry 2004 v.52 no.2 pp. 344-349
ISSN:
0021-8561
Subject:
prunes; plant extracts; abscisic acid; lignans; glucosides; chemical structure; antioxidant activity; free radicals; antioxidants
Abstract:
... Four new abscisic acid related compounds (1-4), together with (+)-abscisic acid (5), (+)-β-D-glucopyranosyl abscisate (6), (6S,9R)-roseoside (7), and two lignan glucosides ((+)-pinoresinol mono-β-D-glucopyranoside (8) and 3-(β-D-glucopyranosyloxymethyl)-2- (4-hydroxy-3-methoxyphenyl)-5-(3-hydroxypropyl)-7-methoxy-(2R,3S)-dihydrobenzofuran (9)) were isolated from the antioxidative ethanol extract o ...
DOI:
10.1021/jf034954v

34. Absolute configuration of (+)-pinoresinol 4-O-[6"-O-galloyl]-β-d-glucopyranoside, macarangiosides E, and F isolated from the leaves of Macaranga tanarius

Author:
Matsunami, Katsuyoshi; Otsuka, Hideaki; Kondo, Kazunari; Shinzato, Takakazu; Kawahata, Masatoshi; Yamaguchi, Kentaro; Takeda, Yoshio
Source:
Phytochemistry 2009 v.70 no.10 pp. 1277-1285
ISSN:
0031-9422
Subject:
Macaranga tanarius; lignans; glucosides; chemical constituents of plants; chemical structure; spectral analysis; stereochemistry; antioxidant activity; Japan
Abstract:
... A lignan glucoside, (+)-pinoresinol 4-O-[6"-O-galloyl]-β-d-glucopyranoside (1), and two megastigmane glucosides, named macarangiosides E and F (2, 3), together with 15 known compounds (4-18) were isolated from leaves of Macaranga tanarius (L.) Müll.-Arg. (Euphorbiaceae). Their structures were elucidated by spectroscopic and chemical analyses. In addition, the absolute stereochemistry of macarangi ...
DOI:
10.1016/j.phytochem.2009.07.020

35. Absolute configuration of podophyllotoxin related lignans from Bursera fagaroides using vibrational circular dichroism

Author:
René Velázquez-Jiménez; J. Martín Torres-Valencia; Carlos M. Cerda-García-Rojas; Juan D. Hernández-Hernández; Luisa U. Román-Marín; J. Jesús Manríquez-Torres; Mario A. Gómez-Hurtado; Alejandro Valdez-Calderón; Virginia Motilva; Sofía García-Mauriño; Elena Talero; Javier Ávila; Pedro Joseph-Nathan
Source:
Phytochemistry 2011 v.72 no.17 pp. 2237-2243
ISSN:
0031-9422
Subject:
Bursera; adenocarcinoma; colon; cytotoxicity; ethanol; humans; lignans; spectroscopy
Abstract:
... The ethanol extract from the dried exudate of Bursera fagaroides (Burseraceae) showed significant cytotoxic activity in the HT-29 (human colon adenocarcinoma) test system. The extract provided four podophyllotoxin related lignans, identified as (7′R,8R,8′R)-(−)-deoxypodophyllotoxin (3), (7′R,8R,8′R)-(−)-morelensin (4), (8R,8′R)-(−)-yatein (5), and (8R,8′R)-(−)-5′-desmethoxyyatein (6), whose spectr ...
DOI:
10.1016/j.phytochem.2011.07.017
PubMed:
21840559

36. Absorption of plant lignans from cereals in an experimental pig model

Author:
Anne Katrine Bolvig; Herman Adlercreutz; Peter Kappel Theil; Henry Jørgensen; Knud Erik Bach Knudsen
Source:
British journal of nutrition 2016 v.115 no.10 pp. 1711-1720
ISSN:
1475-2662
Subject:
absorption; breads; catheters; diet; excretion; ingestion; intestinal microorganisms; lignans; mesenteric arteries; metabolism; models; portal vein; rye flour; seeds; small intestine; swine; urine; wheat; wheat flour; whole grain foods
Abstract:
... Plant lignans are diphenolic compounds ingested with whole grains and seeds and converted to enterolignans by the colonic microbiota. In the present study, we investigated absorption and metabolism of plant lignans and enterolignans in vivo after consumption of cereal-based diets. Six pigs fitted with catheters in the mesenteric artery and portal vein and with a flow probe attached to the portal v ...
DOI:
10.1017/S0007114516000829
PubMed:
27001342

37. Absorption, distribution, metabolism, and excretion of [14C]sesamin in rats

Author:
Namino Tomimori; Tomohiro Rogi; Hiroshi Shibata
Source:
Molecular nutrition & food research 2017 v.61 no.8 pp. -
ISSN:
1613-4125
Subject:
absorption; autoradiography; bile; carbon; cytochrome P-450; excretion; feces; half life; intestinal microorganisms; kidneys; lignans; liver; metabolites; oral administration; pharmacokinetics; radioactivity; radionuclides; rats; sesame seed; tissue distribution; urine
Abstract:
... SCOPE: Sesamin is a major lignan in sesame seeds and has various physiological effects. Although metabolism of sesamin by cytochrome P450 or intestinal microflora has been reported, little is known concerning the mass balance, pharmacokinetics, and tissue distribution of sesamin. METHODS AND RESULTS: Absorption, distribution, metabolism, and excretion of [¹⁴C]sesamin were investigated after a sing ...
DOI:
10.1002/mnfr.201600844

38. Accessing the natural variation of the abundances of major lignans in the heartwood of Taiwania cryptomerioides by ¹H-NMR and LC-MS profiling

Author:
Nai-Wen Tsao; Shin-Hung Pan; Jeng-Der Chung; Yueh-Hsiung Kuo; Sheng-Yang Wang; Ying-Hsuan Sun
Source:
Holzforschung 2019 v.73 no.5 pp. 423-434
ISSN:
1437-434X
Subject:
Taiwania cryptomerioides; biosynthesis; environmental factors; enzymes; genetic factors; genotype; heartwood; heritability; lignans; linear models; liquid chromatography; mass spectrometry; nuclear magnetic resonance spectroscopy; prediction; principal component analysis; provenance; secondary metabolites; wood quality
Abstract:
... Lignans are major bioactive secondary metabolites, which are also formed in the heartwood (hW) of Taiwania (Taiwania cryptomerioides). Their biosynthesis pathways are complex and involve many enzymes and intermediates. To evaluate the extent of the genetic components leading to the variety of lignans in Taiwania hW, 35 Taiwania genotypes of four provenances were surveyed using the proton nuclear m ...
DOI:
10.1515/hf-2018-0117

39. Accumulation of Lignans by in vitro Cultures of Three Linum Species

Author:
Abdolali Mohagheghzadeh; Shadab Dehshahri; Shiva Hemmati
Source:
Zeitschrift für Naturforschung 2014 v.64 no.1-2 pp. 73-76
ISSN:
1865-7125
Subject:
Linum; biomass; callus; cytotoxicity; high performance liquid chromatography; in vitro culture; lignans; medicinal plants; neoplasm cells; plantlets; seedlings; shoots
Abstract:
... Justicidin B, an arylnaphthalene lignan, has strong cytotoxicity on chronic myeloid and chronic lymphoid leukemia cell lines. The first report of the production of justicidin B in a Linum species concerned in vitro culture of Linum austriacum. Therefore, culture characterization and presence of arylnaphthalene-type lignans in calli and plantlets of Linum tenuifolium from section Linastrum, Linum b ...
DOI:
10.1515/znc-2009-1-213

40. Aconitum carmichaelii Debeaux: A systematic review on traditional use, and the chemical structures and pharmacological properties of polysaccharides and phenolic compounds in the roots

Author:
Yu-Ping Fu; Yuan-Feng Zou; Fei-Yi Lei; Helle Wangensteen; Kari Tvete Inngjerdingen
Source:
Journal of ethnopharmacology 2022 v.291 pp. 115148
ISSN:
0378-8741
Subject:
Aconitum carmichaelii; Internet; Oriental traditional medicine; analgesics; benzoic acid; biodegradability; flavonoids; heart failure; immunomodulators; intestines; lignans; myocardial infarction; phenylpropanoids; polysaccharides; rheumatoid arthritis; systematic review; China
Abstract:
... Aconitum carmichaelii, belonging to the Ranunculaceae family, is a widely used traditional herbal plant in Asian countries, especially in China. The lateral (“Fuzi”) and mother (“Chuanwu”) roots are the two main plant parts used in Traditional Chinese Medicine (TCM), where they are used in the treatment of acute myocardial infarction, heart failure, rheumatoid arthritis, and as analgesics. In orde ...
DOI:
10.1016/j.jep.2022.115148

41. Acorus Linnaeus: a review of traditional uses, phytochemistry and neuropharmacology

Author:
Xiao-Lin Feng; Yang Yu; Da-Peng Qin; Hao Gao; Xin-Sheng Yao
Source:
RSC advances 2014 v.5 no.7 pp. 5173-5182
ISSN:
2046-2069
Subject:
Acorus; alkaloids; anticonvulsants; herbs; lignans; phenylpropanoids; rhizomes; sedatives; sesquiterpenoids
Abstract:
... Acorus Linnaeus is a genus of perennial herbs distributed from the northern temperate to the subtropical regions, and has been widely used as traditional folk medicine in China and India since ancient times. Phytochemical studies have shown the presence of numerous beneficial compounds, such as phenylpropanoids, lignans, sesquiterpenoids, alkaloids and others. Neuropharmacological studies have rev ...
DOI:
10.1039/c4ra12049c

42. Action of fungal laccases on lignin model compounds in organic solvents

Author:
Pekka Maijala; Maija-Liisa Mattinen; Paula Nousiainen; Jussi Kontro; Janne Asikkala; Jussi Sipilä; Liisa Viikari
Source:
Journal of molecular catalysis 2012 v.76 no. pp. 59-67
ISSN:
1381-1177
Subject:
Chaetomium; Coriolus hirsutus; Thielavia; aqueous solutions; catalytic activity; dehydrogenation; enzyme activity; ethanol; fungi; gel chromatography; high performance liquid chromatography; industrial applications; laccase; lignans; lignin; matairesinol; nuclear magnetic resonance spectroscopy; oxidation; polymerization; propylene glycol; redox potential; solvents; thermal stability
Abstract:
... The stability and reactivity of five different thermostable fungal laccases from the species Trametes hirsuta, Melanocarpus albomyces, Thielavia arenaria (two laccases) and Chaetomium thermophilum were investigated in the presence of organic solvents. Oxidations of small organic phenolic compounds, matairesinol and 7-hydroxymatairesinol lignans, as well as synthetic lignin dehydrogenation polymer ...
DOI:
10.1016/j.molcatb.2011.12.009

43. Activation of TRPC6 channels contributes to (+)-conocarpan-induced apoptotic cell death in HK-2 cells

Author:
Guoling Yang; Hui Ma; Yanliang Wu; Baoping Zhou; Chunlei Zhang; Chengzhi Chai; Zhengyu Cao
Source:
Food and chemical toxicology 2019 v.129 pp. 281-290
ISSN:
0278-6915
Subject:
apoptosis; calcium; electrophysiology; food plants; humans; inhibitory concentration 50; lignans; median effective concentration; nephrotoxicity; risk; therapeutics
Abstract:
... (+)-Conocarpan (CNCP), a neolignan frequently found in many medicinal and edible plants displays a broad spectrum of bioactivity. Here, we demonstrated that CNCP induced apoptotic cell death in human kidney-2 (HK-2) cells in a concentration-dependent manner (IC₅₀ = 19.3 μM) and led to the sustained elevation of intracellular Ca²⁺ ([Ca²⁺]ᵢ). Lower extracellular Ca²⁺ concentrations from 2.3 mM to 0  ...
DOI:
10.1016/j.fct.2019.04.061

44. Activity in vitro and in vivo against Trypanosoma cruzi of a furofuran lignan isolated from Piper jericoense

Author:
Paola García-Huertas; Francisco Olmo; Manuel Sánchez-Moreno; Jorge Dominguez; Rachid Chahboun; Omar Triana-Chávez
Source:
Experimental parasitology 2018 v.189 pp. 34-42
ISSN:
0014-4894
Subject:
Piper; Trypanosoma cruzi; benznidazole; carbon; drugs; ethyl acetate; human cell lines; leaves; lignans; mechanism of action; metabolism; mice; nuclear magnetic resonance spectroscopy; parasites; spectral analysis; stable isotopes; toxicity; tropics; vegetation
Abstract:
... Piperaceae species are abundant in the tropics and are important components of secondary vegetation. Many of these plants have received considerable attention due to their wide range of biological activities. Here, the trypanocidal activity of extracts and fractions with different polarities obtained from Colombian Piper jericoense plant was evaluated. A furofuran lignan, (1S,3aS,4S,6aS)-1-(3′,4′- ...
DOI:
10.1016/j.exppara.2018.04.009

45. Acutissimanide, a new lignan with antioxidant activity isolated from the bark of Quercus acutissima Carruth

Author:
Xiao-Li Zeng; Guang-Miao Fu; Kai Tian; Jing-Xian Sun; Hua-Bin Xiong; Xiang-Zhong Huang; Zhi-Yong Jiang
Source:
Natural product research 2014 v.28 no.17 pp. 1364-1370
ISSN:
1478-6427
Subject:
Quercus acutissima; additives; antioxidant activity; antioxidants; bark; industry; lignans; lignin; mass spectrometry; nuclear magnetic resonance spectroscopy; polyphenols
Abstract:
... Acutissimanide (1), a new lignin, together with 11 known polyphenols (2–12) were isolated from the bark of the deciduous oak tree, Quercus acutissima Carruth. The structure of compound 1 was determined using multidimensional ¹H and ¹³C NMR and mass spectroscopy. The antioxidant properties of compounds 1–12 were investigated using a 1,1-diphenyl-2-picryhydrazyl radical-scavenging assay with compoun ...
DOI:
10.1080/14786419.2014.905557

46. Acyl flavone and lignan glucosides from Leontopodium leontopodioides

Author:
Yangyang Xiao; Haihui Xie; Li Zhao; Ping Gou
Source:
Phytochemistry letters 2016 v.17 pp. 247-250
ISSN:
1874-3900
Subject:
Leontopodium; acarbose; alpha-glucosidase; glucosides; inhibitory concentration 50; lignans; spectroscopy
Abstract:
... Two new acyl flavone glucosides, luteolin-4⿲-O-(6-p-hydroxybenzoyl)-β-d-glucopyranoside (leontopodioside A, 1) and luteolin-4⿲-O-[6-(2-methylbutyryl)]-β-d-glucopyranoside (leontopodioside B, 2), and a new acyl lignan glucoside, lariciresinol-9-angeloyl-4-O-β-d-glucopyranoside (leontopodiosideC, 3) were isolated from the whole plants of Leontopodium leontopodioides (Asteraceae). Their structures we ...
DOI:
10.1016/j.phytol.2016.08.006

47. Acyl glycosides lignans, coumarins, and terpenes from the stems of Erycibe obtusifolia

Author:
Zhao-zhen Liu; Zhi-lai Zhan; Fu Liu; Ya-nan Yang; Zi-ming Feng; Jian-shuang Jiang; Pei-cheng Zhang
Source:
Carbohydrate research 2013 v.372 no. pp. 47-54
ISSN:
0008-6215
Subject:
coumarins; cytotoxicity; ethanol; glycosides; hepatoprotective effect; lignans; nuclear magnetic resonance spectroscopy; spectral analysis; stems; terpenoids
Abstract:
... Nine new acyl glycosides, obtusifosides A–I (1–9), and eight known compounds have been isolated from an EtOH extract of the stems of Erycibe obtusifolia. Their structures were elucidated on the basis of a spectroscopic data analysis (NMR, HRESIMS, and CD) and chemical evidence. The hepatoprotective effects of some of the compounds from d-galactosamine-induced cytotoxicity in HL-7702 hepatic cells ...
DOI:
10.1016/j.carres.2013.02.006

48. Acylated Lignans Isolated from Brachanthemum gobicum and Their Trypanocidal Activity

Author:
Batsukh Odonbayar; Toshihiro Murata; Keisuke Suganuma; Yoshinobu Ishikawa; Buyanmandakh Buyankhishig; Javzan Batkhuu; Kenroh Sasaki
Source:
Journal of natural products 2019 v.82 no.4 pp. 774-784
ISSN:
1520-6025
Subject:
Asteraceae; Trypanosoma congolense; aerial parts; animals; bovine trypanosomiasis; enantiomers; high performance liquid chromatography; lignans; nuclear magnetic resonance spectroscopy
Abstract:
... Eight isovaleryllignans (1–4 and 8–11), three isovalerylphenylpropanoids (5–7), three known lignans (12–14), and four known compounds were isolated from an extract of the aerial part of Brachanthemum gobicum. The structures of the isolated compounds were elucidated based on NMR and MS data analyses. The enantiomers of compounds 1–3, 5, 8, and 9 were isolated using chiral-phase HPLC, and the absolu ...
DOI:
10.1021/acs.jnatprod.8b00670

49. Adding lignan values to a food composition database

Author:
Blitz, C.L.; Murphy, S.P.; Au, D.L.M.
Source:
Journal of food composition and analysis 2007 v.20 no.2 pp. 99-105
ISSN:
0889-1575
Subject:
matairesinol; data collection; nutrient databanks; lignans; plant-based foods; food composition; East Asia
Abstract:
... The dietary lignans secoisolariciresinol (SEC) and matairesinol (MAT) are phytoestrogens structurally similar to the hormone estrogen and may exert estrogenic effects in the body. Quantification of dietary intake of phytoestrogens is of particular interest for the study of hormone-related diseases. The purpose of this project was to expand the Cancer Research Center of Hawaii Food Composition Tabl ...
DOI:
10.1016/j.jfca.2006.05.006

50. Adipogenic constituents from the bark of Larix laricina du Roi (K. Koch; Pinaceae), an important medicinal plant used traditionally by the Cree of Eeyou Istchee (Quebec, Canada) for the treatment of type 2 diabetes symptoms

Author:
Nan Shang; José A. Guerrero-Analco; Lina Musallam; Ammar Saleem; Asim Muhammad; Brendan Walshe-Roussel; Alain Cuerrier; John T. Arnason; Pierre S. Haddad
Source:
Journal of ethnopharmacology 2012 v.141 no.3 pp. 1051-1057
ISSN:
0378-8741
Subject:
Larix laricina; acids; bark; disease outbreaks; diterpenoids; fractionation; lignans; lipogenesis; medicinal plants; noninsulin-dependent diabetes mellitus; nuclear magnetic resonance spectroscopy; screening; stilbenes; surveys; taxifolin; traditional medicine; triacylglycerols; Quebec
Abstract:
... ETHNOPHARMACOLOGICAL RELEVANCE: Diabetes is a growing epidemic worldwide, especially among indigenous populations. Larix laricina was identified through an ethnobotanical survey as a traditional medicine used by Healers and Elders of the Cree of Eeyou Istchee of northern Quebec to treat symptoms of diabetes and subsequent in vitro screening confirmed its potential. MATERIALS AND METHODS: We used a ...
DOI:
10.1016/j.jep.2012.04.002
PubMed:
22542642