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1. Bioactive compounds of purslane (Portulaca oleracea L.) according to the production system: A review

Author:
César Omar Montoya-García; Rosario García-Mateos; Elvia Becerra-Martínez; Rocío Toledo-Aguilar; Víctor Hugo Volke-Haller; J. Jesús Magdaleno-Villar
Source:
Scientia horticulturae 2023 v.308 pp. 111584
ISSN:
0304-4238
Subject:
Philippines; Portulaca oleracea; abiotic stress; antioxidants; chemical composition; crop management; dietary supplements; flavonoids; glycosides; herbaceous plants; human health; hydroponics; lignans; metabolome; metabolomics; polysaccharides; sterols; terpenoids; Australia; Brazil; China; Greece; Iran; Italy; Malaysia; Mexico; Northern Africa; Spain; United Kingdom
Abstract:
... Purslane (Portulaca oleracea L.) is an herbaceous plant consumed in Italy, the United Kingdom, Spain, Greece, Turkey, Iran, Malaysia, the Philippines, China, North Africa, Australia, the United States, Brazil, and Mexico. Purslane contains nutraceutical compounds that can be potentiated based on biotic and abiotic stress practices. It provides substantial contributions of minerals, polysaccharides ...
DOI:
10.1016/j.scienta.2022.111584

2. Simulated gastrointestinal digestion/Caco-2 cell transport: Effects on biological activities and toxicity of a Brazilian propolis

Author:
Ana Sofia Martelli Chaib Saliba; Alan Giovanini de Oliveira Sartori; Pollyanna Souza Batista; José Eduardo Pedroso Gomes do Amaral; Namuhell Oliveira da Silva; Masaharu Ikegaki; Pedro Luiz Rosalen; Severino Matias de Alencar
Source:
Food chemistry 2023 v.403 pp. 134330
ISSN:
0308-8146
Subject:
Galleria mellonella; antimicrobial properties; chemical constituents of plants; chemokine CXCL2; digestion; digestive tract; food chemistry; food composition; functional foods; gastrointestinal system; human cell lines; interleukin-6; lethal dose; lignans; macrophages; phytochemicals; propolis; reactive oxygen species; transcription factors; Brazil
Abstract:
... The objective was to assess the effect of gastrointestinal digestion/Caco-2 cell transport on biological activities and toxicity of the ethanolic extract of organic propolis from southern Brazil (EEOP1). As principal results, the EEOP1 deactivated the ROO•, HOCl and O₂•⁻ reactive oxygen species, attenuated NF-κB transcription factor activation, and decreased the release of TNF-α and IL-6 in macrop ...
DOI:
10.1016/j.foodchem.2022.134330

3. (+)-Sesamin, a sesame lignan, is a potent inhibitor of gut bacterial tryptophan indole-lyase that is a key enzyme in chronic kidney disease pathogenesis

Author:
Daiki Oikawa; Satoshi Yamashita; Seiji Takahashi; Toshiyuki Waki; Koichi Kikuchi; Takaaki Abe; Takane Katayama; Toru Nakayama
Source:
Biochemical and biophysical research communications 2022 v.590 pp. 158-162
ISSN:
0006-291X
Subject:
Escherichia coli; active sites; dietary supplements; enzymes; intestines; kidney diseases; kidneys; lignans; mice; morbidity; pathogenesis; phytochemicals; pyridoxal; research; sulfates; therapeutics; toxins; tryptophan
Abstract:
... The progression of chronic kidney disease (CKD) increases the risks of cardiovascular morbidity and end-stage kidney disease. Indoxyl sulfate (IS), which is derived from dietary l-tryptophan by the action of bacterial l-tryptophan indole-lyase (TIL) in the gut, serves as a uremic toxin that exacerbates CKD-related kidney disorder. A mouse model previously showed that inhibition of TIL by 2-aza-l-t ...
DOI:
10.1016/j.bbrc.2021.12.088

4. Aconitum carmichaelii Debeaux: A systematic review on traditional use, and the chemical structures and pharmacological properties of polysaccharides and phenolic compounds in the roots

Author:
Yu-Ping Fu; Yuan-Feng Zou; Fei-Yi Lei; Helle Wangensteen; Kari Tvete Inngjerdingen
Source:
Journal of ethnopharmacology 2022 v.291 pp. 115148
ISSN:
0378-8741
Subject:
Aconitum carmichaelii; Internet; Oriental traditional medicine; analgesics; benzoic acid; biodegradability; flavonoids; heart failure; immunomodulators; intestines; lignans; myocardial infarction; phenylpropanoids; polysaccharides; rheumatoid arthritis; systematic review; China
Abstract:
... Aconitum carmichaelii, belonging to the Ranunculaceae family, is a widely used traditional herbal plant in Asian countries, especially in China. The lateral (“Fuzi”) and mother (“Chuanwu”) roots are the two main plant parts used in Traditional Chinese Medicine (TCM), where they are used in the treatment of acute myocardial infarction, heart failure, rheumatoid arthritis, and as analgesics. In orde ...
DOI:
10.1016/j.jep.2022.115148

5. Agrimonia pilosa Ledeb.: A review of its traditional uses, botany, phytochemistry, pharmacology, and toxicology

Author:
Sihua Wen; Xiaofei Zhang; Yanan Wu; Shangshang Yu; Wei Zhang; Ding Liu; Kai Yang; Jing Sun
Source:
Heliyon 2022 v.8 no.8 pp. e09972
ISSN:
2405-8440
Subject:
Agrimonia pilosa; Internet; Japan; Oriental traditional medicine; antioxidants; calcium oxide; dysentery; enteritis; flavonoids; gastrointestinal system; grasses; herbal medicines; isocoumarins; lignans; malaria; pharmacokinetics; toxicology; triterpenoids; China; Korean Peninsula
Abstract:
... Agrimonia pilosa Ledeb. is the dried above-ground part of dragon's tooth grass, a plant of the Rosaceae family, which is widely distributed in China, Korea, and Japan. Agrimonia pilosa Ledeb. is a herbal medicine with great scope for development and use. It is astringent and hemostatic, and it is used for treating malaria, preventing dysentery, detoxification, and as a tonic for deficiency. We sum ...
DOI:
10.1016/j.heliyon.2022.e09972

6. Alleviation of cognitive deficits via upregulation of chondroitin sulfate biosynthesis by lignan sesamin in a mouse model of neuroinflammation

Author:
Jun Yamada; Shoichiro Maeda; Mariko Soya; Hidefumi Nishida; Kyoko M. Iinuma; Shozo Jinno
Source:
Journal of nutritional biochemistry 2022 v.108 pp. 109093
ISSN:
0955-2863
Subject:
Wisteria floribunda; adults; agglutinins; biosynthesis; chondroitin sulfate; cognition; estrogens; extracellular matrix; hippocampus; lignans; lipopolysaccharides; locomotion; memory; mice; neurogenesis; proteoglycans
Abstract:
... Lignans are plant-derived compounds that act as partial estrogen agonists. Chondroitin sulfate proteoglycans (CSPGs) represent one of the major components of the extracellular matrix. Here we aimed to understand the role of sesamin (SES), a major lignan compound, in the biosynthesis and degradation of CSPGs in the mouse hippocampus because CSPGs play a key role in the regulation of cognitive funct ...
DOI:
10.1016/j.jnutbio.2022.109093

7. Amino ether analogues of 4,4′-dihydroxy-3-methoxy-6,7′-cyclolignan and their activity against drug-resistant bacteria

Author:
Guillermo Núñez-Mojica; Martha L. Hernández-Carrillo; Francisco G. Avalos-Alanís; Elvira Garza-González; Verónica M. Rivas-Galindo; David A. Silva-Mares; Marc-Antoine Bazin; Pascal Marchand; María del Rayo Camacho-Corona
Source:
Phytochemistry letters 2022 v.50 pp. 57-60
ISSN:
1874-3900
Subject:
Enterococcus faecium; Larrea tridentata; Mycobacterium tuberculosis; active ingredients; antibacterial properties; drug resistance; lignans; plant biochemistry; spectral analysis
Abstract:
... Larrea tridentata antibacterial lignan 4,4′-dihydroxy-3-methoxy-6,7′-cyclolignan (1) was derivatized to obtain eleven new amino ether derivatives (2 A-12 C). The structural elucidation of compounds was performed by analysis of 1D- and 2D NMR spectral data and HRESIMS. The antibacterial activity of compounds was determined against nine drug-resistant bacteria and two strains of Mycobacterium tuberc ...
DOI:
10.1016/j.phytol.2022.05.004

8. Anti-Inflammatory Benzofuran Neolignans from the Fruits of Canarium album (Chinese Olive)

Author:
Jiming Li; Ru Wang; Yihai Wang; Jia Zeng; Zeyong Xu; Jingwen Xu; Xiangjiu He
Source:
Journal of agricultural and food chemistry 2022 v.70 no.4 pp. 1122-1133
ISSN:
1520-5118
Subject:
Canarium album; circular dichroism spectroscopy; enantiomers; food chemistry; fruits; interleukin-6; lignans; macrophages; nitric oxide; phytochemicals; China
Abstract:
... Chinese olive is a well-known fruit in China. In this study, we explored anti-inflammatory phytochemicals of Chinese olive fruit, which led to the isolation of nine pairs of new enantiomers of benzofuran neolignans (1a/1b–9a/9b). Among them, the planar structures of compounds 1–3 were undescribed previously, and the absolute configurations of all compounds were reported first. Their stereostructur ...
DOI:
10.1021/acs.jafc.1c06457

9. Anti-Inflammatory Phytoconstituents of Origanum Majorana

Author:
Li Zhou; Senye Wang; Jiaojiao Qu; Huihui Zhou; Al-Zahra K. K. Attia Fatma; Wenyi Kang; Xuefeng Xi; Zhenhua Liu
Source:
Journal of food quality 2022 v.2022 pp. -
ISSN:
1745-4557
Subject:
Origanum majorana; arthritis; asthma; chemical constituents of plants; ethanol; fever; flavonoids; food quality; glycosides; hypertension; influenza; lignans; migraine; spices; Egypt
Abstract:
... Origanum majorana belongs to the Lamiaceae family as a famous spice plant in Egypt, which is used to treat arthritis, allergies, fever, flu, hypertension, respiratory infections, migraine, and asthma. In our studies, it was found that the ethanol extract of O. marjoram could significantly reduce NO release at 200 (P<0.001), 100 (P<0.001) and 50 (P<0.01) μg/mL compared with the model group. Therefo ...
DOI:
10.1155/2022/3888075

10. Anti-hypoxic active constituents from the twigs of Zanthoxylum armatum DC. and their chemotaxonomic significance

Author:
Xiao-Xue Zhai; Xian-Hua Meng; Cheng-Bo Wang; Ya-Min Zhao; Jun-Li Yang
Source:
Biochemical systematics and ecology 2022 v.104 pp. 104480
ISSN:
0305-1978
Subject:
Zanthoxylum armatum; chemotaxonomy; ecology; lignans; phytochemicals; spectral analysis
Abstract:
... Phytochemical investigation of the twigs of Zanthoxylum armatum DC. led to the extraction and isolation of twenty-one compounds, including nine phenolic acids (1–9), a steroid (10) and eleven lignans (11–21). The structures of these compounds were elucidated by NMR spectroscopic analysis, and comparison with the reported data. Compounds 1–7, 15, 17, 18, and 21 were first obtained from Z. armatum. ...
DOI:
10.1016/j.bse.2022.104480

11. Anti-inflammatory and cytotoxic specialised metabolites from the leaves of Glandularia × hybrida

Author:
Nesma M. Mohamed; Mai A.M. Ahmed; Shabana I. Khan; Frank R. Fronczek; Anber F. Mohammed; Samir A. Ross
Source:
Phytochemistry 2022 v.195 pp. 113054
ISSN:
0031-9422
Subject:
Glandularia; computer simulation; cytotoxicity; lignans; metabolites; pharmacokinetics; phytochemicals; triterpenoid saponins
Abstract:
... In our ongoing effort to investigate active specialised metabolites from genus Glandularia, phytochemical studies on the ethanolic extract of Glandularia × hybrida (Groenl. & Rümpler) G.L. Nesom & Pruski leaves resulted in the isolation of three undescribed compounds, a dibenzylbutyrolactolic lignan and two echinocystic acid based triterpenoid saponins, in addition to two known compounds. Interest ...
DOI:
10.1016/j.phytochem.2021.113054

12. Anti-influenza activity of compounds isolated from the leaves of Elsholtzia rugulosa and their chemotaxonomic significance

Author:
Shi-yan Feng; Lu Zhang; Lun-li Xiang; Rong-tao Li; Xuan-qin Chen; Fei Yu; Jin-dong Zhong
Source:
Biochemical systematics and ecology 2022 v.103 pp. 104441
ISSN:
0305-1978
Subject:
Elsholtzia; benzene; chemotaxonomy; diterpenoids; ecology; flavonoids; lignans; monoterpenoids; phenolic acids; phenylpropanoids; sesquiterpenoids
Abstract:
... A phytochemical investigation on the leaves of Elsholtzia rugulosa resulted in the isolation and identification of thirty compounds, including four flavonoids (1–4), two benzene derivatives, two lignans (7 and 8), three phenylpropanoids (9–11), three phenolic acid (12–14), five sesquiterpenes (15–19), five nor-sesquiterpenes (20–24), one diterpenoids (25), and four monoterpenoids (26–30). Among of ...
DOI:
10.1016/j.bse.2022.104441

13. Antioxidant lignans sesamin and sesamolin in sesame (Sesamumindicum L.): a comprehensive review and future prospects

Author:
Senouwa Segla Koffi Dossou; Fang-tao XU; Komivi Dossa; Rong ZHOU; Ying-zhong ZHAO; Lin-hai WANG
Source:
Journal of integrative agriculture 2022 pp. -
ISSN:
2095-3119
Subject:
Sesamum indicum; agriculture; antioxidants; biosynthesis; cash crops; cultivars; germplasm; imports; lignans; oils; oilseed crops
Abstract:
... Sesame (Sesamum indicum L.) is a significantly lucrative cash crop for millions of small-holder farmers. Its seeds are an important source of a world highly appreciated oil and two clinically essential antioxidant lignans, sesamin and sesamolin. Accordingly, many countries import annually millions of tons of sesame seeds. The demand for lignan-rich sesame seeds is increasing yearly due to the cont ...
DOI:
10.1016/j.jia.2022.08.097

14. Antiviral and Antioxidant Components from the Fruits of Illicium verum Hook.f. (Chinese Star Anise)

Author:
Wen Li; Zhongnan Wu; Yiping Xia; Jinlin Tan; Haiyue Zhao; Si Chen; Yaolan Li; Hongfeng Tang; Guocai Wang; Yubo Zhang
Source:
Journal of agricultural and food chemistry 2022 v.70 no.12 pp. 3697-3707
ISSN:
1520-5118
Subject:
Illicium verum; Orthomyxoviridae; anise; antioxidants; antiviral properties; circular dichroism spectroscopy; cuisine; cytopathogenicity; electrospray ionization mass spectrometry; fluorescent antibody technique; food chemistry; fruits; lignans; oseltamivir; phenylpropanoids; phytochemicals; spectral analysis; South East Asia
Abstract:
... Illicium verum Hook.f. (Chinese star anise), a known Chinese traditional spice, is commonly applied in Chinese cuisine and cooking in Southeast Asia. As a kind of medicinal and edible resource, the fruit of I. verum has attracted great attention for its chemical constituents and physiological activities. In this work, the phytochemical study of the fruits of I. verum led to the isolation and ident ...
DOI:
10.1021/acs.jafc.1c08376

15. Asymmetric total synthesis of four bioactive lignans using donor–acceptor cyclopropanes and bioassay of (−)- and (+)-niranthin against hepatitis B and influenza viruses

Author:
Ryotaro Ota; Daichi Karasawa; Mizuki Oshima; Koichi Watashi; Noriko Shimasaki; Yoshinori Nishii
Source:
RSC advances 2022 v.12 no.8 pp. 4635-4639
ISSN:
2046-2069
Subject:
antiviral properties; bioassays; hepatitis B; influenza; lignans; matairesinol
Abstract:
... The asymmetric total synthesis of four lignans, dimethylmatairesinol, matairesinol, (−)-niranthin, and (+)-niranthin has been achieved using reductive ring-opening of cyclopropanes. Moreover, we performed bioassays of the synthesized (+)- and (−)-niranthins using hepatitis B and influenza viruses, which revealed the relationship between the enantiomeric structure and the anti-viral activity of nir ...
DOI:
10.1039/d2ra00499b

16. Bassiamide A, a new alkaloid from xero-halophyte Bassia indica Wight.

Author:
Ahmed Othman; Yhiya Amen; Masako Matsumoto; Maki Nagata; Kuniyoshi Shimizu
Source:
Natural product research 2022 v.36 no.14 pp. 3610-3618
ISSN:
1478-6427
Subject:
alkaloids; lignans; octopamine; research; spectral analysis
Abstract:
... N-[(3-(3-methyl-1-oxo-butyl)amino)propyl]-3-(3,4-dihydroxyphenyl)prop-2-enamide (7), named ‘Bassiamide A’, a new alkaloid, together with six known compounds including one lignan (1) and five lignanamides (2–6), were isolated from the aerial parts of Bassia indica Wight. The study also reported an optimal separation of a rare occurring R-isomer lignanamide derivative (6) from a natural origin, in a ...
DOI:
10.1080/14786419.2021.1872572

17. The Bioactive Compounds and Fatty Acid Profile of Bitter Apple Seed Oil Obtained in Hot, Arid Environments

Author:
Mukesh Kumar Berwal; Chet Ram; Pawan Singh Gurjar; Jagan Singh Gora; Ramesh Kumar; Ajay Kumar Verma; Dhurendra Singh; Boris Basile; Youssef Rouphael; Pradeep Kumar
Source:
Horticulturae 2022 v.8 no.3 pp. -
ISSN:
2311-7524
Subject:
Citrullus colocynthis; antioxidant activity; carotenoids; catechin; color; dietary supplements; drought; farms; fatty acid composition; fruits; health promotion; heat; lignans; linoleic acid; oleic acid; oryzanol; palmitic acid; risk; sand; seed oils; soil salinity; specific gravity; stearic acid
Abstract:
... Bitter apple or tumba (Citrullus colocynthis L.) is a prostrate annual herb belonging to the Cucurbitaceae family. It is highly tolerant against multiple abiotic stresses like drought, heat, and soil salinity and can easily grow on very marginal soil, even on sand dunes in hot, arid regions. Tumba fruit is a fleshy berry 5–10 cm in diameter and of a pale yellow color at ripening. The tumba fruit u ...
DOI:
10.3390/horticulturae8030259

18. Bioactive neolignans and lignans from the roots of Paeonia lactiflora

Author:
Huan XIA; Jing-Fang ZHANG; Ling-Yan WANG; Gui-Yang XIA; Ya-Nan WANG; Yu-Zhuo WU; Peng-Cheng LIN; Liang XIONG; Sheng LIN
Source:
Chinese journal of natural medicines 2022 v.20 no.3 pp. 210-214
ISSN:
1875-5364
Subject:
Paeonia lactiflora; X-ray diffraction; carboxylesterase; circular dichroism spectroscopy; enantiomers; humans; lignans; spectral analysis
Abstract:
... Two new neolignans and one new lignan (1–3) were obtained from the roots of Paeonia lactiflora. Their structures were unambiguously elucidated based on extensive spectroscopic analysis, single-crystal X-ray crystallography, and the calculated and experimental electronic circular dichroism (ECD) spectra. Compound 1 was a racemic mixture and successfully resolved into the anticipated enantiomers via ...
DOI:
10.1016/S1875-5364(22)60164-X

19. Bioassay-Guided Fractionation and Dereplication Studies of Sesame oil: Isolation of 8-Acetoxypinoresinol as an Anti-Proliferative Metabolite and Prediction of Target

Author:
Yedu K. Nalli; Santosh K. Guru; Priti Jain; Vishal Mishra; Shreyans K. Jain
Source:
Proceedings of the National Academy of Sciences, India, Section B: biological sciences 2022 v.92 no.3 pp. 595-601
ISSN:
0369-8211
Subject:
DNA; Sesamum indicum; antineoplastic activity; cell cycle checkpoints; cytotoxicity; fractionation; high performance liquid chromatography; lignans; metabolites; nuclear magnetic resonance spectroscopy; prediction; sesame oil; sesame seed; India
Abstract:
... Sesamum indicum is a plant cultivated mainly in South Asia. It is rich in lignans and dietary fatty acids. The lignans of furofuran class are reported to display many pharmacological activities; therefore, the source of dietary sesame oil was used as biological material for investigation. Bioassay-guided fractionation followed by Liquid Chromatography-Mass Spectroscopy and Dictionary of Natural Pr ...
DOI:
10.1007/s40011-021-01308-0

20. Bioassay-guided fractionation and isolation of Arctigenin from Saussurea heteromalla for in vitro and in silico cytotoxic activity against HeLa cells

Author:
Azra Batool; Ghulam Abbas Miana; Mahboob Alam; Muhammad Tariq Khan; Muhammad Muddassir; Wajid Zaman; Saifullah Khan; Akhtar Aman; Ameer Khusro; Mariadhas Valan Arasu; Naif Abdullah Al-Dhabi; Ki Choon Choi; Muhammad Umar Khayam Sahibzada
Source:
Physiological and molecular plant pathology 2022 v.117 pp. 101749
ISSN:
0885-5765
Subject:
Himalaiella heteromalla; Saussurea; computer simulation; cytotoxicity; fractionation; lignans; matairesinol; mechanism of action; neoplasm antigens; plant pathology; secondary metabolites; traditional medicine; uterine cervical neoplasms
Abstract:
... Ethnopharmacological relevance of Saussurea species to anticancer compounds instigated the present research. Therefore to search the bioactive anticancer lead compound (s) scientifically bioactivity guided fractionation of Saussurea heteromalla (Compositae) was carried out that resulted in the isolation and characterization of three butyrolactone (lignan) secondary metabolites i.e. arctigenin (1), ...
DOI:
10.1016/j.pmpp.2021.101749

21. Bis-iridoids and other constituents from Scabiosa semipapposa

Author:
Samia Bendamene; Naima Boutaghane; Charlotte Sayagh; Abdulmagid Alabdul Magid; Zahia Kabouche; Chawki Bensouici; Laurence Voutquenne-Nazabadioko
Source:
Phytochemistry letters 2022 v.49 pp. 202-210
ISSN:
1874-3900
Subject:
Scabiosa; antioxidant activity; antioxidants; chemotaxonomy; flavonoids; glycosides; iridoids; lignans; mass spectrometry; phenol; spectral analysis
Abstract:
... Six undescribed bis-iridoids named Semipapposiridoids A–F (1–6) together with seventeen known compounds were obtained from the roots and aerial parts of Scabiosa semipapposa Salzm. ex DC. Among the known compounds, three lignans were isolated for the first time in Scabiosa species, whereas the other known constituents including iridoids, phenol glycosides and flavonoids were previously isolated fr ...
DOI:
10.1016/j.phytol.2022.04.005

22. Breeding history for shattering trait in sesame: classic to genomic approach

Author:
Moin Qureshi; D. Ray Langham; Stuart J. Lucas; Bulent Uzun; Engin Yol
Source:
Molecular biology reports 2022 v.49 no.7 pp. 7185-7194
ISSN:
0301-4851
Subject:
CRISPR-Cas systems; RNA interference; antioxidants; genes; genomics; lignans; mechanical harvesting; mechanization; molecular biology; mutagenesis; nucleases; oils; oilseed crops; protein content; zinc finger motif
Abstract:
... Sesame is an important oilseed crop that has high oil and protein content and unique antioxidant lignans. Capsule shattering at harvest is one of the most important problems affecting sesame production, with seed losses of up to 50%, making the crop unsuitable for mechanized harvesting. This paper provides an overview of breeding approaches addressing the capsule shattering trait in sesame and giv ...
DOI:
10.1007/s11033-022-07636-2

23. Caucasian Dragonheads: Phenolic Compounds, Polysaccharides, and Bioactivity of Dracocephalum austriacum and Dracocephalum botryoides

Author:
Nina I. Kashchenko; Gunay S. Jafarova; Javanshir I. Isaev; Daniil N. Olennikov; Nadezhda K. Chirikova
Source:
Plants 2022 v.11 no.16 pp. -
ISSN:
2223-7747
Subject:
Dracocephalum; antioxidant activity; arabinogalactan proteins; benzoic acid; chemical composition; cuisine; flavonoids; lignans; liquid chromatography; mass spectrometry; metabolites; methanol; phenylpropanoids; polysaccharides; traditional medicine; water solubility; Caucasus region
Abstract:
... Dracocephalum botryoides Steven and Dracocephalum austriacum L. are unexplored species of the Dracocephalum genus (Lamiaceae family) with a distribution in the Caucasus, where they are used in folk medicine and local cuisine. There are no data on the chemical composition of these Dracocephalum species. In this study, the application of a liquid chromatography-mass spectrometry technique for the me ...
DOI:
10.3390/plants11162126

24. Characteristic constituents with chemotaxonomic significance from the gum resin of Boswelliacarterii

Author:
Zhi-Chao Chen; Fang-You Chen; Lian-Lian Xu; Bao Yang; Yong-Ming Luo
Source:
Biochemical systematics and ecology 2022 v.104 pp. 104478
ISSN:
0305-1978
Subject:
Boswellia; chemotaxonomy; diterpenoids; ecology; flavonoids; gum resin; lignans; spectral analysis; triterpenoids
Abstract:
... Chemical investigation on the gum resin of Boswellia carterii afforded 14 compounds, including three triterpenoids (1-3), one nortriterpenoid (4), five cembrane-type macrocyclic diterpenoids (5–9), three prenylaromadendrane-type diterpenoids (10–12), one flavonoid (13), and one lignan (14). The structures of these compounds were established via spectroscopic analysis and comparison of their NMR da ...
DOI:
10.1016/j.bse.2022.104478

25. Characterization of chemical constituents in Shuanghuanglian oral dosage forms by ultra‐high performance liquid chromatography coupled with time‐of‐flight mass spectrometry

Author:
Ruiyun Li; Yanru Zhu; Mingyan Ma; Min Lei; Yingchun Zhao; Ting Liu; Miao Yu; Yunli Zhao; Zhiguo Yu
Source:
Journal of separation science 2022 v.45 no.5 pp. 1020-1030
ISSN:
1615-9306
Subject:
Oriental traditional medicine; anthraquinones; caffeic acid; coumarins; flavonoids; iridoids; lignans; mass spectrometry; oral administration; separation; triterpenoids; ultra-performance liquid chromatography
Abstract:
... Shuanghuanglian is a common traditional Chinese medicine prescription. It is an herbal formula composed of Lonicerae Japonicae Flos, Scutellariae Radix, and Forsythiae Fructus. A comprehensive understanding of Shuanghuanglian oral dosage forms components was obtained using a method based on ultra‐high performance liquid chromatography coupled with time‐of‐flight mass spectrometry for the separatio ...
DOI:
10.1002/jssc.202100860

26. Characterization of chemical constituents with their antioxidant and anti-melanogenesis activities from the roots of Ampelopsis japonica

Author:
Chia-Lin Lee; Yun-Lian Jhan; Hsiu-Mei Chiang; Yi-Hung Chen; Chao-Jung Chen; Yuan-Shiun Chang
Source:
Natural product research 2022 v.36 no.12 pp. 3133-3137
ISSN:
1478-6427
Subject:
Ampelopsis; anthraquinones; cosmetics; free radicals; glycosylation; keratinocytes; lignans; melanin; melanoma; research; stilbenes
Abstract:
... Three glycosylated stilbenes (1–3), two anthraquinones (4, 5), one lignan (6), five tannins (7–11), two amino acids (12, 13), and one auronol (14) were isolated from the root of Ampelopsis japonica. All compounds, except for 4, 6, and 11 were obtained from this species for the first time. Compounds 6–9 could notably inhibit ROS generations in HaCaT keratinocyte cells with IC₅₀ values of 5.28, 4.83 ...
DOI:
10.1080/14786419.2021.1939335

27. Characterization, expression, and functional analysis of the pathogenesis-related gene PtDIR11 in transgenic poplar

Author:
Lingling Li; Weibo Sun; Pu Wang; Hongyan Li; Shamsur Rehman; Dawei Li; Qiang Zhuge
Source:
International journal of biological macromolecules 2022 v.210 pp. 182-195
ISSN:
0141-8130
Subject:
Populus trichocarpa; biosynthesis; cell membranes; coniferyl alcohol; disease resistance; ethylene; flavonoids; genes; immunity; jasmonic acid; lignans; lignin; lignin content; methanol; pathogenesis-related proteins; quantitative polymerase chain reaction; reverse transcription; salicylic acid; signal transduction
Abstract:
... Lignins and lignans are important for plant resistance to pathogens. Dirigent (DIR) proteins control the regio- and stereo-selectivity of coniferyl alcohol in lignan and lignin biosynthesis. DIR genes have been implicated in defense-related responses in several plant species, but their role in poplar immunity is unclear. We cloned PtDIR11 from Populus trichocarpa; we found that overexpression of P ...
DOI:
10.1016/j.ijbiomac.2022.05.012

28. Chemical Constituents from Acanthopanax senticosus and Their Cytotoxic Activities

Author:
Ying-Ying Wei; Peng Han; Jia-Qi Yue; Fan Li
Source:
Chemistry of natural compounds 2022 v.58 no.4 pp. 610-613
ISSN:
0009-3130
Subject:
Eleutherococcus senticosus; chemistry; cytotoxicity; humans; lignans; spectroscopy
Abstract:
... A new lignan, named 1,6-bis-(3-methoxy-4-hydroxyphenyl)hexane-1,6-dione (1), together with seven known compounds (2–8) were isolated from the EtOAc-soluble extract of Acanthopanax senticosus. Their structures were elucidated based on extensive spectroscopic analyses. All isolates were evaluated for in vitro cytotoxic activity against human cancer cells of HepG2, A549, HeLa, and MCF-7. Among them, ...
DOI:
10.1007/s10600-022-03753-3

29. Chemical and biological studies of Daphniphyllum oldhamii from Hunan Province, China

Author:
Yi Chen; Shou-Mao Shen; Min Yang; Ming-Zhi Su; Xiao-Ming Wang; Yue-Wei Guo
Source:
Phytochemistry 2022 v.199 pp. 113170
ISSN:
0031-9422
Subject:
Daphniphyllum; X-ray diffraction; lignans; plant biochemistry; spectral analysis; triterpenoids; China
Abstract:
... The fruits, twigs and leaves of Daphniphyllum oldhamii (Hemsl.) K. Rosenthal, collected from Longshan County, Hunan Province, China, were chemically investigated. Three undescribed daphniphyllum alkaloids, namely longshanoldhamines A‒C, and six known related ones have been isolated from the fruits, whereas two undescribed triterpenoids and one undescribed lignan, along with six known triterpenoids ...
DOI:
10.1016/j.phytochem.2022.113170

30. Chemical constituents and aldose reductase inhibitory activities of Betula alba bark and leaves

Author:
Tomoki Iguchi; Minpei Kuroda; Nanami Akiyama; Mariko Hashimoto; Yoshihiro Mimaki
Source:
Natural product research 2022 v.36 no.4 pp. 1004-1008
ISSN:
1478-6427
Subject:
Betula pubescens var. pubescens; aldehyde reductase; bark; flavanones; glucosides; lignans; methyl salicylate; monoterpenoids; research; spectral analysis; triterpenoids
Abstract:
... Systematic phytochemical investigation of the bark and leaves of Betula alba was independently conducted. A new cyclic diarylheptanoid glucoside (1), five diarylheptanoids (2–6), a phenylethanoid (7), a methyl salicylate glycoside (8), a dihydrobenzofuran glucoside (9), an arylbutanoid glycoside (10), two lignan glycosides (11 and 12), a flavanone glucoside (13), and a triterpene (14) were isolate ...
DOI:
10.1080/14786419.2020.1839455

31. Chemical constituents and their antioxidant and anti-inflammatory activities from edible Cornus officinalis fruits

Author:
Zhongcan Peng; Yuming Wang; Jun He; Jia Zhang; Xuege Pan; Xiansheng Ye; Weiku Zhang; Jiekun Xu
Source:
European food research & technology 2022 v.248 no.4 pp. 1003-1010
ISSN:
1438-2377
Subject:
2,2-diphenyl-1-picrylhydrazyl; Cornus officinalis; acid hydrolysis; cell lines; electrospray ionization mass spectrometry; food production; food research; functional foods; inflammation; interleukin-6; lignans; lipopolysaccharides; macrophages; nitric oxide; phytochemicals; technology; traditional medicine
Abstract:
... Cornus officinalis fruits, an edible functional food with the tonic effect, belongs to the Cornaceae family. It is widely used in both traditional medicine and in some food production. A phytochemical study on the fruits of Cornus officinalis resulted in 20 structurally diverse compounds including 2 new lignans, named officinalignans A-B (1–2), and 2 new iridoids, named loganin-(4′-O-7″)-α-morroni ...
DOI:
10.1007/s00217-021-03940-6

32. Chemical constituents from Dracocephalum moldavica L. and their chemotaxonomic significance

Author:
Jiaming Wang; Jinfeng Sun; Mengjie Wang; Huiqiong Cui; Wei Zhou; Gao Li
Source:
Biochemical systematics and ecology 2022 v.102 pp. 104422
ISSN:
0305-1978
Subject:
Dracocephalum moldavica; chemotaxonomy; ecology; glycosides; lignans; monoterpenoids; norisoprenoids; phytochemicals; spectral analysis; triterpenoids
Abstract:
... A phytochemical investigation of the aerial parts of Dracocephalum moldavica L. (Lamiaceae) led to the isolation and characterization of 30 compounds, including eight lignans (1–8), seven phenols (9–15), five triterpenoids (16–20), four monoterpenoids (21–24), four glycosides (25–28) and two megastigmanes (29 and 30). The structures of these compounds were determined by spectroscopic data analysis ...
DOI:
10.1016/j.bse.2022.104422

33. Chemical constituents from Machilus salicina Hance

Author:
Shun-Yi Yang; Gao-Hua Jiang; Qiong-Hui Sun; Qing Luo; Chao-Xun Wang; Bo Liu; Rui Zhan; Haji Akber Aisa; Ye-gao Chen
Source:
Biochemical systematics and ecology 2022 v.103 pp. 104432
ISSN:
0305-1978
Subject:
Machilus; amides; betulin; chemotaxonomy; ecology; indoles; kaempferol; lignans; lupane; lupeol; taxifolin
Abstract:
... This first phytochemical investigation on the leaves and stems of Machilus salicina Hance led to the isolation of thirteen compounds, including lupeol (1), betulin (2), meso-dihydroguaiaretic acid (3), isoguaiacin (4), nectandrin B (5), kaempferol (6), taxifolin (7), (2R,3R)-3-hydroxy-5,7-dimethoxy-3′,4′-methylenedioxy-flavan (8), cinnacassin N (9), 1H-indole-3-carboxaldehyde (10), 3-[p-hydroxyphe ...
DOI:
10.1016/j.bse.2022.104432

34. Chemical constituents from Maytenus hookeri

Author:
Nian Jiang; Changyan Yu; Jing Hui; Jianxun Xie; Yuanyuan Wang; Jun Yang; Sanhua Li; Lingjie Meng
Source:
Biochemical systematics and ecology 2022 v.104 pp. 104475
ISSN:
0305-1978
Subject:
Maytenus; chemotaxonomy; ecology; lignans; phenylpropanoids; phytochemicals; saponins; spectral analysis; triterpenoids
Abstract:
... A phytochemical investigation on the branches of Maytenus hookeri resulted in the isolation and identification of fourteen compounds, including one new triterpene saponin (1), five phenylpropanoids (2–6), and eight lignans (7–14). The chemical structures of these compounds were determined by comprehensive spectroscopic data analysis, such as UV, IR, 1D/2D NMR, mass spectra, and data from the liter ...
DOI:
10.1016/j.bse.2022.104475

35. Chemical constituents from Salvinia natans (L.) All. (Salviniaceae) and their chemotaxonomic significance

Author:
Hien Giang Pham; Manh Tuan Ha; Thao Quyen Cao; Ngoc Khanh Vu; Thi Thanh Le; Byung Sun Min
Source:
Biochemical systematics and ecology 2022 v.102 pp. 104410
ISSN:
0305-1978
Subject:
Salvinia natans; chemotaxonomy; ecology; lignans; norisoprenoids; phenanthrenes; phytochemicals; spectral analysis
Abstract:
... The phytochemical research on Salvinia natans (L.) All. resulted in the isolation of 11 compounds, subdivided into four steroids (1–4), three megastigmanes (5–7), two lignans (8 and 9), one phenanthrene (10), and one nepetolactone derivative (11). The structures of these compounds were elucidated mainly by NMR spectroscopic analysis and comparison with the published data. All these compounds were ...
DOI:
10.1016/j.bse.2022.104410

36. Chemical constituents from Semiliquidambar chingii and their chemotaxonomic significance

Author:
Jingyi Zhang; Kumaravel Kaliaperumal; Ziyue Liu; Jun Zhang
Source:
Biochemical systematics and ecology 2022 v.100 pp. 104360
ISSN:
0305-1978
Subject:
Altingia; Liquidambar; chemotaxonomy; coniferyl alcohol; ecology; ellagic acid; flavonoids; glycosides; hybrids; lignans; resveratrol; shikimic acid; spectral analysis; triterpenoids
Abstract:
... The present study investigated the phytochemical constituents of Semiliquidambar chingii for the first time, resulting in the isolation and characterization of nineteen compounds which were categorized into eight groups as resveratrol derivatives (1–4), triterpenoids (5–10), flavonoids (11–13), phenolic glycosides (14–15), lignan (16), ellagic acid derivative (17), coniferyl alcohol derivative (18 ...
DOI:
10.1016/j.bse.2021.104360

37. Chemical constituents from the aerial parts of Achillea alpina and their chemotaxonomic significance

Author:
Xiuwei Li; Xia Wu; Qiang Guo; Changli Liu; Hucheng Yue; Jiayi Tian; Zongyang Liu; Meng Xiao; Ang Li; Zhongqi Ning; Ke Zan; Xiaoqing Chen
Source:
Biochemical systematics and ecology 2022 v.101 pp. 104381
ISSN:
0305-1978
Subject:
Achillea; chemotaxonomy; ecology; lignans; phytochemicals; sesquiterpenoids; spectral analysis
Abstract:
... Phytochemical investigation of the aerial parts of Achillea alpina led to the isolation of sixteen compounds, including six sesquiterpenes (1-6), two polyacetylenic alcohols (7-8), three lignans (9-11), and five fatty acids (12-16). Their structures were identified by spectroscopic analysis of UV, IR, MS and NMR, and in comparison with the those reported data in the references. Among them, five co ...
DOI:
10.1016/j.bse.2022.104381

38. Chemical constituents from the fruits of Illicium simonsii and their antiviral activity and neuroprotective effect

Author:
Guo-Zhu Su; Mi Li; Xiao-Jing Wang; Ru-Bing Wang; Shuang-Gang Ma; Dan Zhang; Xiao-Liang Wang; Li Li; Yun-Bao Liu; Jing Qu; Yu-Huan Li; Yong Li; Shi-Shan Yu
Source:
Phytochemistry 2022 v.202 pp. 113323
ISSN:
0031-9422
Subject:
Illicium; X-ray diffraction; antiviral properties; diterpenoids; lignans; neuroprotective effect; plant biochemistry; sesquiterpenoids; spectral analysis; viruses
Abstract:
... One undescribed diterpenoid illisimonone A, four undescribed sesquiterpenes named (±)-simonones A, simonterpenoids A and B, and two undescribed lignans, illisimonins A and B, along with five known compounds were isolated from the fruits of Illicium simonsii. Their structures were elucidated by extensive spectroscopic data. The absolute configuration of illisimonone A was determined by single-cryst ...
DOI:
10.1016/j.phytochem.2022.113323

39. Chemical constituents from the fruits of Solanum nigrum and their chemotaxonomic significance

Author:
Bo-Han Yang; Yi-Jie Zhang; Ming Bai; Qian Zhang; Chen-Xi Li; Xiao-Xiao Huang; Shao-Jiang Song
Source:
Biochemical systematics and ecology 2022 v.103 pp. 104452
ISSN:
0305-1978
Subject:
Solanum nigrum; chemotaxonomy; ecology; lignans; phytochemicals; spectroscopy
Abstract:
... A phytochemical investigation of the fruits of Solanum nigrum L. led to the isolation of 17 compounds including ten lignans (1–10) and seven amide alkaloids (11–17). Their structures were elucidated by extensive spectroscopic methods and comparison with literature data. All the compounds were isolated from S.nigrum, firstly. Besides, a plant network analysis of all isolated compounds was presented ...
DOI:
10.1016/j.bse.2022.104452

40. Chemical constituents from the fruits of Vitex rotundifolia and their chemotaxonomic significance

Author:
Yong-Ming Luo; Rui-Zeng Zhang; Fang-You Chen
Source:
Biochemical systematics and ecology 2022 v.103 pp. 104440
ISSN:
0305-1978
Subject:
Vitex rotundifolia; alkaloids; chemotaxonomy; diterpenoids; ecology; iridoids; lignans; spectral analysis; xanthones
Abstract:
... Chemical investigation on the fruits of Vitex rotundifolia Linnaeus f. Afforded 19 compounds, including three diterpenoids (1-3), two iridoids (4 and 5), three xanthones (6–8), an alkaloid (9), seven lignans (10–16), and three sesquilignans (17–19). The structures of these compounds were established via spectroscopic analysis and comparison of their NMR data with the literature. Compounds 1, 6–9, ...
DOI:
10.1016/j.bse.2022.104440

41. Chemical constituents from the leaves of Caesalpinia bonduc (L.) Roxb. and their chemotaxonomic significance

Author:
Le Thi Huyen; Vu Hoang Son; Truong Thi Viet Hoa; Luong Thi My Hanh; Seo Yohan; Park SeonJu; Nguyen Xuan Nhiem; Dan Thi Thuy Hang; Phan Van Kiem; Bui Huu Tai
Source:
Biochemical systematics and ecology 2022 v.100 pp. 104376
ISSN:
0305-1978
Subject:
Caesalpinia bonduc; chemotaxonomy; ecology; flavonoids; lignans; spectral analysis
Abstract:
... Caesalpinia bonduc (L.) Roxb. is an important herb in Ayurvedic medicines. In this study, five lignans (1–5), two phloroglucinols (6–7), five flavonoids (8–12) and four phenolics (13–16) were identified from the leaves of C. bonduc by comparison with spectroscopic data published in the literature. To the best of our knowledge, all of these identified phytochemicals were reported for the first time ...
DOI:
10.1016/j.bse.2021.104376

42. Chemical constituents from the roots of Actinidia valvata Dunn

Author:
Changwei Song; Chunbo Yu; Ying Qin; Jing Hui; Yong Zhang; Shengyan Qian; Lin Xu; Yun Liu
Source:
Biochemical systematics and ecology 2022 v.100 pp. 104371
ISSN:
0305-1978
Subject:
Actinidia; butanol; chemotaxonomy; coumarins; ecology; glycosides; lignans; phenylpropanoids; secondary metabolites; spectral analysis
Abstract:
... A previous undescribed dihydrobenzofuran neolignan (1), as well as eleven known phenolic derivatives (2–12) were isolated from the n-butanol fraction of the roots of Actinidia valvata Dunn, including five phenylpropanoids (2–6), four phenolic glycosides (7–10) and two coumarins (11–12). The chemical structures of these compounds were identified by means of extensive spectroscopic analysis and comp ...
DOI:
10.1016/j.bse.2021.104371

43. Chemical constituents of Antidesma bunius aerial parts and the anti-AGEs activity of selected compounds

Author:
Hieu Nguyen-Ngoc; Mostafa Alilou; Séverine Derbré; Patricia Blanchard; Giang Nam Pham; Duc Trong Nghiem; Pascal Richomme; Hermann Stuppner; Markus Ganzera
Source:
Phytochemistry 2022 v.202 pp. 113300
ISSN:
0031-9422
Subject:
Antidesma bunius; Euphorbiaceae; advanced glycation end products; diabetes; lignans; metabolites; moieties; rheumatoid arthritis; rutin; traditional medicine
Abstract:
... Thirty-three natural products were isolated from the aerial parts of Antidesma bunius, Euphorbiaceae, a plant used in Vietnamese traditional medicine against rheumatoid arthritis. All compounds were reported the first time for this species, and nine constituents resembled undescribed natural products, noticeably three coumarinolignans with 2,2-dimethyl-1,3-dioxolane moiety, two cyclopeptides, and ...
DOI:
10.1016/j.phytochem.2022.113300

44. Chemical constituents of the pericarp of Toona sinensis and their chemotaxonomic significance

Author:
Ying Chen; Feng Wang; Chaoying Ji; Di Liu; Xiaoxiao Liu; Rongshen Wang; Wanzhong Li
Source:
Biochemical systematics and ecology 2022 v.104 pp. 104458
ISSN:
0305-1978
Subject:
Toona sinensis; chemotaxonomy; ecology; flavonoids; lignans; pericarp; sesquiterpenoids; spectral analysis; sterols; triterpenoids
Abstract:
... Phytochemical investigation of the pericarp of Toona sinensis (A. Juss.) Roem (Meliaceae) led to the isolation and identification of 33 compounds, namely, 7 apotirucallane-type triterpenoids (1–7), 2 cycloartane-type triterpenoids (8–9), 5 sterols (10–14), 2 sesquiterpenes (15–16), 2 lignans (17–18), 3 flavonoids (19–21), and 12 phenols (22–33). The chemical structures of these compounds were eluc ...
DOI:
10.1016/j.bse.2022.104458

45. Chemical profiling of Justicia vahlii Roth. (Acanthaceae) using UPLC-QTOF-MS and GC-MS analysis and evaluation of acute oral toxicity, antineuropathic and antioxidant activities

Author:
Abdul Basit; Saeed Ahmad; Kashif ur Rehman Khan; Abid Naeem; Muhammad Usman; Imtiaz Ahmed; Muhammad Nadeem Shahzad
Source:
Journal of ethnopharmacology 2022 v.287 pp. 114942
ISSN:
0378-8741
Subject:
2,2-diphenyl-1-picrylhydrazyl; Artemia; Justicia; acetic acid; acute oral toxicity; animal models; antioxidant activity; antioxidants; bioactive compounds; catalase; chemical constituents of plants; coumarins; death; flavonoids; glutathione; inflammation; interleukin-1beta; lignans; maceration; mortality; necrosis; nerve tissue; pain; secondary metabolites; tail; toxicity testing; traditional medicine
Abstract:
... Justicia vahlii Roth. (Acanthaceae), also called as kodasoori and bhekkar is an annual therophyte erect or decumbent herb used traditionally in toothache, skin diseases (itching, topical inflammation) and for the treatment of various respiratory disorders.The current study aimed at exploring pain cessation potential of J. vahlii Roth. via murine model of neuropathic pain and its phytochemical, tox ...
DOI:
10.1016/j.jep.2021.114942

46. Chemical profiling, quantitation, and bioactivities of Du-Zhong tea

Author:
Xiqing Shi; Shengbo Luo; Kan Zhong; Xinghua Hu; Zijia Zhang
Source:
Food chemistry 2022 v.394 pp. 133552
ISSN:
0308-8146
Subject:
Eucommia ulmoides; antioxidants; beverages; carboxylic ester hydrolases; flavonoids; food chemistry; iridoids; lignans; phenylpropanoids; tea
Abstract:
... Du-Zhong tea is a health beverage produced from Eucommia ulmoides leaves (EUL) as raw materials using traditional tea processing and Chinese herbal pieces processing methods. To evaluate the differences between tender leaves and mature leaves of Du-Zhong tea, UPLC-Q-TOF MS was used to analyze the constituents in EUL collected in April and August. A total of 52 compounds, including iridoids, phenyl ...
DOI:
10.1016/j.foodchem.2022.133552

47. Cistanche deserticola polysaccharides extracted from Cistanche deserticola Y.C. Ma promote the differentiation of mouse female germline stem cells in vitro

Author:
Yikai Qiu; Yanping Zhang; Hehe Ren; Yingxin Zhang; Xinrui Liu; Jing Pu; Jianqiang Yu; Xiaoli Yu; Xiuying Pei
Source:
Journal of ethnopharmacology 2022 v.296 pp. 115495
ISSN:
0378-8741
Subject:
Cistanche deserticola; Oriental traditional medicine; Western blotting; bone morphogenetic proteins; cell differentiation; cell proliferation; cell structures; cell viability; culture media; females; fluorescent antibody technique; gene expression; gene expression regulation; genes; glycosides; iridoids; lignans; mice; oocytes; phenylethyl alcohol; polysaccharides; quantitative polymerase chain reaction; retinoic acid; sequence analysis; signal transduction; synaptonemal complex; China
Abstract:
... Traditional Chinese herbal medicine Cistanche deserticola Y.C. Ma has been recorded and treatment for infertility and impotence since ancient times, which is widely distributed in northwest China, and is mainly composed of phenylethanol glycosides, iridoids, lignans, polysaccharides, alkaloids, etc. C. deserticola polysaccharides (CDPs) is one of its main active ingredients, studies of its effect ...
DOI:
10.1016/j.jep.2022.115495

48. Combination of UHPLC‐Q Exactive‐Orbitrap MS and network pharmacology to reveal the mechanism of Eucommia ulmoides leaves in the treatment of osteoarthritis

Author:
Tao Liu; Xingze Cao; Dongmin Cao
Source:
Journal of food biochemistry 2022 v.46 no.8 pp. e14204
ISSN:
0145-8884
Subject:
Eucommia ulmoides; flavonoids; iridoids; lignans; medicine; osteoarthritis; pharmacology; quality of life; rapid methods; therapeutics; ultra-performance liquid chromatography
Abstract:
... Osteoarthritis (OA) is a disabling disease and seriously affects the quality of life of patients. is A potential medicine for the treatment of OA is Eucommia ulmoides leaves (EULs). However, its active compounds and therapeutic mechanisms are unclear. Therefore, it is necessary to develop a method using LC–MS and network pharmacology for the detection and identification of compounds and the mechan ...
DOI:
10.1111/jfbc.14204

49. Combined transcriptome and metabolome analysis of Nerium indicum L. elaborates the key pathways that are activated in response to witches’ broom disease

Author:
Shengjie Wang; Shengkun Wang; Ming Li; Yuhang Su; Zhan Sun; Haibin Ma
Source:
BMC plant biology 2022 v.22 no.1 pp. 291
ISSN:
1471-2229
Subject:
Nerium oleander; Sophora chrysophylla; biosynthesis; brooms; coumarins; disease incidence; flavonoids; gene expression regulation; host-pathogen relationships; hypersensitive response; lignans; linoleic acid; metabolites; metabolome; metabolomics; nicotinamide; ornamental plants; pathogens; phenylpropanoids; phloem; plant hormones; signal transduction; surveys; transcriptome; tricarboxylic acid cycle; unigenes; China
Abstract:
... BACKGROUND: Nerium indicum Mill. is an ornamental plant that is found in parks, riversides, lakesides, and scenic areas in China and other parts of the world. Our recent survey indicated the prevalence of witches’ broom disease (WBD) in Guangdong, China. To find out the possible defense strategies against WBD, we performed a MiSeq based ITS sequencing to identify the possible casual organism, then ...
DOI:
10.1186/s12870-022-03672-z

50. Comparative effects of sesame lignans (sesamin, sesamolin, and sesamol) on oxidative stress and lipid metabolism in steatosis HepG2 cells

Author:
Longkai Shi; Emad Karrar; Ruijie Liu; Ming Chang; Xingguo Wang
Source:
Journal of food biochemistry 2022 v.46 no.8 pp. e14180
ISSN:
0145-8884
Subject:
beta oxidation; catabolism; cholesterol; fatty liver; genes; lignans; lipemic effect; lipogenesis; liver; models; oxidative stress; peroxisome proliferator-activated receptors; sesame oil; therapeutics
Abstract:
... Non‐alcoholic fatty liver disease (NAFLD) can be attributed to the imbalance between lipogenesis and lipidolysis in the liver. Sesame lignans (sesamin, sesamolin, and sesamol) are unique bioactive compounds responsible for the nutritional function of sesame oils. However, the preventive effects of three lignans on oxidative stress and lipid metabolism in steatosis HepG2 cells have not been compare ...
DOI:
10.1111/jfbc.14180

51. Comparative metabolite fingerprinting of chia, flax and sesame seeds using LC-MS untargeted metabolomics

Author:
Federico I. Brigante; Natalia S. Podio; Daniel A. Wunderlin; Maria V. Baroni
Source:
Food chemistry 2022 v.371 pp. 131355
ISSN:
0308-8146
Subject:
Salvia hispanica; data collection; flax; food chemistry; lignans; metabolites; metabolomics; nutritive value; polyphenols; seeds
Abstract:
... Chia, flax, and sesame seeds are well known for their nutritional quality and are commonly included in bakery products. So far, the development of methods to verify their presence and authenticity in foods is a requisite and a raised need. In this work we applied untargeted metabolomics to propose authenticity markers. Seeds were analyzed by HPLC-MS/MS and 9938 features in negative mode and 9044 i ...
DOI:
10.1016/j.foodchem.2021.131355

52. Comparative metabolomic study of three clones of Eucommia ulmoides wood

Author:
Shuan Ren; Manrong Zha; Youji Li; Ke Song; Jian He; Shima Liu; Jie Guo; Kegang Li; Xianwu Zhou
Source:
Journal of wood chemistry and technology 2022 v.42 no.4 pp. 318-329
ISSN:
1532-2319
Subject:
Eucommia ulmoides; biosynthesis; coumarins; flavonoids; lignans; lysine; metabolomics; nucleotides; secondary metabolites; terpenoids; wood; wood chemistry
Abstract:
... It is important to reveal the differences in the metabolites of different clones of Eucommia wood to explore the beneficial components of Eucommia wood and the selection of Eucommia wood. In this study, an extensive targeted metabolomic analysis was conducted on three different clones of Eucommia wood, Huazhong 12 Eucommia (HZ), Cili Eucommia (CL), and Miye Eucommia (MY), using UPLC-EI-MS/MS analy ...
DOI:
10.1080/02773813.2022.2088794

53. Comprehensive characterization and identification of chemical constituents in Yangwei decoction using ultra high performance liquid chromatography coupled with electrospray ionization quadrupole time‐of‐flight tandem mass spectrometry

Author:
Shuaishuai Fan; Baolin Li; Yurou Tian; Wei Feng; Liying Niu
Source:
Journal of separation science 2022 v.45 no.5 pp. 1006-1019
ISSN:
1615-9306
Subject:
Oriental traditional medicine; cold; electrospray ionization mass spectrometry; flavonoids; glycosides; lactones; lignans; pharmacology; separation; tandem mass spectrometry; triterpenoids; ultra-performance liquid chromatography
Abstract:
... Yangwei decoction, a classical traditional Chinese medicine prescription, has been widely used to treat exogenous cold and internal injury with damp stagnation for many centuries. However, its systematic chemical profiling remains ambiguous, which has hampered the interpretation of pharmacology and the mechanism of its formula. In the present study, ultra‐performance liquid chromatography coupled ...
DOI:
10.1002/jssc.202100723

54. Consumption of sesame seeds and sesame products has favorable effects on blood glucose levels but not on insulin resistance: A systematic review and meta‐analysis of controlled clinical trials

Author:
Mohammad Hassan Sohouli; Niloufar Haghshenas; Ángela Hernández‐Ruiz; Farzad Shidfar
Source:
Phytotherapy research 2022 v.36 no.3 pp. 1126-1134
ISSN:
0951-418X
Subject:
blood glucose; blood serum; glucose; humans; insulin; insulin resistance; lignans; meta-analysis; metabolism; phytotherapy; research; sesame oil; systematic review
Abstract:
... Sesame, with an oily seed containing oil, lignans, and proteins, is a popular plant that has demonstrated health benefits such as antioxidative, antiobesity, and antiinflammatory effects. In this systematic review and meta‐analysis, we aimed to summarize the effect of sesame seeds and their consumption compared to a control group on blood glucose and insulin resistance in human adults. PubMed/MEDL ...
DOI:
10.1002/ptr.7379

55. Copper nanoclusters-based fluorescent sensor array to identify metal ions and dissolved organic matter

Author:
Jinming Xu; Huangmei Zhou; Yixue Zhang; Yu Zhao; Hao Yuan; Xiaoxiao He; Ying Wu; Sanjun Zhang
Source:
Journal of hazardous materials 2022 v.428 pp. 128158
ISSN:
0304-3894
Subject:
discriminant analysis; fluorescence; glutathione; histidine; lignans; polyethyleneimine; principal component analysis; rapid methods; riparian areas; seawater; tap water; water pollution; water quality
Abstract:
... In recent years, the prevention and control of water pollution has received extensive attention. There is a need to develop simple and effective strategies for the rapid detection of metal ions and dissolved organic matter (DOM) in order to improve water quality. To this end, the first copper nanoclusters (CuNCs)-based fluorescent sensor array was done to identify 12 metal ions (Pb²⁺, Fe³⁺, Cu²⁺, ...
DOI:
10.1016/j.jhazmat.2021.128158

56. Correlation between phytocompounds and pharmacological activities of Boerhavia diffusa Linn with traditional-ethnopharmacological insights

Author:
Praveen Kumar Gaur; Sameer Rastogi; Kanak Lata
Source:
Phytomedicine plus 2022 v.2 no.2 pp. 100260
ISSN:
2667-0313
Subject:
Ayurvedic medicine; Boerhavia diffusa; antioxidants; cardiovascular diseases; ecdysteroids; edema; humans; inflammation; kidneys; lignans; nephroprotective effect; nutrient content; polyphenols; rotenoids; wastelands; wet season; Africa; Asia; North America; South America
Abstract:
... : The human body is almost 70% water and fluid imbalance has been a classic symptom of severe underlying conditions, i.e., hepatic disorders, kidney disorders, cardiovascular disease and inflammation. Boerhavia diffusa Linn. is a pantropical herb used in traditional medicine systems worldwide for inflammation, liver-kidney disorders, skin problems, etc. Ethnopharmacological reports of B. diffusa c ...
DOI:
10.1016/j.phyplu.2022.100260

57. Corrigendum to “A new phenylethyl glycoside and a new dibenzocyclooctadiene lignan from the leaves of Kadsura coccinea (Lem.) A. C. Smith” [Phytochem. Lett. 45 (2021) 57–62]

Author:
Le Huyen Tram; Tran Thu Huong; Le Thi Thuy; Nguyen Van Thong; Nguyen Tuan Anh; Nguyen Hoang Minh; Tran Thi Minh; Nguyen Thi Hong Phuong; Tran Thu Ha; Nguyen Hai Dang; Duc Dat Le; Pham Phuoc Dien; Mina Lee
Source:
Phytochemistry letters 2022 v.48 pp. 132-137
ISSN:
1874-3900
Subject:
Kadsura coccinea; circular dichroism spectroscopy; glycosides; hydrolysis; lignans; lipopolysaccharides; mass spectrometry; nitric oxide; nuclear magnetic resonance spectroscopy; plant biochemistry
Abstract:
... A new phenylethyl glycoside (1), (S)-1-phenylethyl-6-α-L-arabinopyranosyl-β-D-glucopyranoside), and a new dibenzocyclooctadiene lignan (7), Kasuracin A, together with seven known compounds, were isolated and identified from the leaves of Kadsura coccinea. Their structures were determined by analysis of multinuclear and multidimensional nuclear magnetic resonance (NMR), circular dichroism (CD), mas ...
DOI:
10.1016/j.phytol.2021.09.013

58. Coumarins and lignans from the roots of Zanthoxylum nitidum

Author:
Jian-Hui Su; Ming-Qiang Wang; Li-Ping Zhu; Wei-Qun Yang; Shi-Qin Jiang; Zhong-Xiang Zhao; Zhang-Hua Sun
Source:
Biochemical systematics and ecology 2022 v.101 pp. 104399
ISSN:
0305-1978
Subject:
Oriental traditional medicine; Zanthoxylum nitidum; chemotaxonomy; coumarin; ecology; glycosides; lignans; phytochemicals
Abstract:
... The phytochemical investigation of the Chinese medicine Zanthoxylum nitidum led to the isolation of a new coumarin glycoside (1), seven known coumarins (2–8) and two known lignan glycosides (9–10). Their structures were elucidated based on extensive spectroscopic methods (HRESIMS, 1D and 2D NMR experiments) and by comparison with literature data. The new compound (1) was a linear furanocoumarin gl ...
DOI:
10.1016/j.bse.2022.104399

59. Countering Triple Negative Breast Cancer via Impeding Wnt/β-Catenin Signaling, a Phytotherapeutic Approach

Author:
Laleh Arzi; Homa Mollaei; Reyhane Hoshyar
Source:
Plants 2022 v.11 no.17 pp. -
ISSN:
2223-7747
Subject:
animals; apoptosis; breast neoplasms; drug therapy; flavonoids; herbal medicines; lignans; metastasis; mortality; phytotherapy; retinoids; stem cells
Abstract:
... Triple negative breast cancer (TNBC) is characterized as a heterogeneous disease with severe malignancy and high mortality. Aberrant Wnt/β-catenin signaling is responsible for self-renewal and mammosphere generation, metastasis and resistance to apoptosis and chemotherapy in TNBC. Nonetheless, in the absence of a targeted therapy, chemotherapy is regarded as the exclusive treatment strategy for th ...
DOI:
10.3390/plants11172191

60. Cytotoxic alkaloids from the root of Zanthoxylum paracanthum (mildbr) Kokwaro

Author:
Leonidah Kerubo Omosa; Vaderament-A Nchiozem-Ngnitedem; Justus Mukavi; Brenda Atieno Okoko; Helder Ombui Nyaboke; Ibrahim Hashim; Jackson Obegi Matundura; Thomas Efferth; Michael Spiteller
Source:
Natural product research 2022 v.36 no.10 pp. 2518-2525
ISSN:
1478-6427
Subject:
Zanthoxylum; amides; cell lines; cytotoxicity; doxorubicin; lignans; multiple drug resistance; neoplasm cells; research; spectroscopy
Abstract:
... Chemical investigation of the root of Zanthoxylum paracanthum afforded 1 new alkamide derivative, (2E,4E)-6-oxo-N-isobutyldeca-2,4-dienamide (1) together with 10 known congeners including one phenolic amide (2), four benzophenanthridines (3 − 6), three indolonaphthyridines (7 − 9) and two lignans (10 and 11). Their structures were elucidated by a combination of spectroscopic and spectrometric data ...
DOI:
10.1080/14786419.2021.1913586

61. Depletion of cyanogenic glycosides in whole flaxseed via Lactobacillaceae fermentation

Author:
Chao Huang; Timothy J. Tse; Sarah K. Purdy; Farley Chicilo; Jianheng Shen; Venkatesh Meda; Martin J. T. Reaney
Source:
Food chemistry 2022 pp. 134441
ISSN:
0308-8146
Subject:
Lactobacillaceae; cyanogenic glycosides; fatty acid composition; feeds; fermentation; food chemistry; functional foods; imports; ingestion; lignans; linseed; linseed oil; mixed culture; nutrient uptake
Abstract:
... Flaxseed is categorized as a functional food due to its abundance in oil, α-linolenic acid, dietary fibres, and lignans. However, flaxseed contains cyanogenic glycosides (CGs). Ingestion of CGs can influence nutrient absorption and induce adverse health effects. Due to the presence of CGs in flaxseed many countries prohibit the import and sale of flaxseed and flaxseed-based foods. In this study, w ...
DOI:
10.1016/j.foodchem.2022.134441

62. Development of a high-frequency adventitious shoot regeneration using cotyledon explants of an important oilseed crop Sesamum indicum L.

Author:
Priyanka Rajput; Parinita Agarwal; D. R. Gangapur; Pradeep K. Agarwal
Source:
In vitro cellular & developmental biology 2022 v.58 no.3 pp. 470-478
ISSN:
1054-5476
Subject:
Sesamum indicum; abscisic acid; acetic acid; benzyladenine; biotechnology; cotyledons; genetic improvement; gibberellic acid; indole acetic acid; lignans; oilseed crops; rooting; thidiazuron; vegetative growth
Abstract:
... Sesame (Sesamum indicum L.; 2n = 26) is an ancient oil-yielding crop known for its valuable nutrients such as essential fatty acids, proteins, and medicinally important lignans. Recalcitrant nature of sesame limits the use of modern biotechnology for its genetic improvement. For the development of an efficient in vitro regeneration protocol, the cotyledon (de-embryonated) explants were used for th ...
DOI:
10.1007/s11627-021-10247-4

63. Diphyllin Shows a Broad-Spectrum Antiviral Activity against Multiple Medically Important Enveloped RNA and DNA Viruses

Author:
Michal Štefánik; Dattatry Shivajirao Bhosale; Jan Haviernik; Petra Straková; Martina Fojtíková; Lucie Dufková; Ivana Huvarová; Jiří Salát; Jan Bartáček; Jan Svoboda; Miloš Sedlák; Daniel Růžek; Andrew D. Miller; Luděk Eyer
Source:
Viruses 2022 v.14 no.2 pp. -
ISSN:
1999-4915
Subject:
DNA; Oriental traditional medicine; RNA; Rabies lyssavirus; Rift Valley fever phlebovirus; Tick-borne encephalitis virus; West Nile virus; Zika virus; acidification; adenosinetriphosphatase; antiviral agents; antiviral properties; cytotoxicity; endocytosis; herpes simplex; lignans; membrane fusion; pH; phylogeny; vacuoles; viruses
Abstract:
... Diphyllin is a natural arylnaphtalide lignan extracted from tropical plants of particular importance in traditional Chinese medicine. This compound has been described as a potent inhibitor of vacuolar (H⁺)ATPases and hence of the endosomal acidification process that is required by numerous enveloped viruses to trigger their respective viral infection cascades after entering host cells by receptor- ...
DOI:
10.3390/v14020354

64. Dirigent gene family is involved in the molecular interaction between Panax notoginseng and root rot pathogen Fusarium solani

Author:
Jie Deng; Ruipan Guan; Tingting Liang; Linlin Su; Feng Ge; Xiuming Cui; Diqiu Liu
Source:
Industrial crops and products 2022 v.178 pp. 114544
ISSN:
0926-6690
Subject:
Fusarium solani; Nicotiana tabacum; Panax notoginseng; Sclerotinia sclerotiorum; biosynthesis; cell walls; genes; lignans; lignin; pathogens; phylogeny; quantitative polymerase chain reaction; root rot; tobacco
Abstract:
... Root rot, mainly caused by Fusarium solani, severely reduces the yield and quality of Panax notoginseng (Burk) F.H. Chen. Dirigent (DIR) proteins catalyze the coupling of lignin monomers during lignin biosynthesis, making them important components of plant defense systems. In this study, a small P. notoginseng DIR gene family was isolated from P. notoginseng. A phylogenetic analysis indicated that ...
DOI:
10.1016/j.indcrop.2022.114544

65. Distribution of lignans and lignan mono/diglucosides within Ginkgo biloba L. stem

Author:
Min Yu; Dan Aoki; Takuya Akita; Syunya Fujiyasu; Shunsuke Takada; Yasuyuki Matsushita; Masato Yoshida; Kazuhiko Fukushima
Source:
Phytochemistry 2022 v.196 pp. 113102
ISSN:
0031-9422
Subject:
Ginkgo biloba; biosynthesis; glucosides; lignans; mass spectrometry; parenchyma (plant tissue); phloem; pith; plant biochemistry
Abstract:
... To investigate the biosynthetic pathways and regulatory mechanisms of lignans in plants, the actual distributions of lignans and lignan glucosides in flash-frozen stems of Ginkgo biloba L. (Ginkgoaceae) were studied using cryo time-of-flight secondary ion mass spectrometry coupled with scanning electron microscopy (cryo-TOF-SIMS/SEM). Four lignans and four lignan glucosides were successfully chara ...
DOI:
10.1016/j.phytochem.2022.113102

66. Distribution of lignans in Panicum miliaceum, Fagopyrum esculentum, Fagopyrum tataricum, and Amaranthus hypochondriacus

Author:
Jana Pexová Kalinová; Iveta Marešová; Jan Tříska; Naděžda Vrchotová
Source:
Journal of food composition and analysis 2022 v.106 pp. 104283
ISSN:
0889-1575
Subject:
Amaranthus hypochondriacus; Fagopyrum esculentum; Fagopyrum tataricum; Panicum miliaceum subsp. miliaceum; buckwheat; food composition; lignans; lignin content; roots
Abstract:
... The distribution of lignans within common millet, common buckwheat, tartary buckwheat, and amaranth plants, as well as any differences of their contents within their different varieties and samples from different growing seasons, were determined by LC–MS analyses. Roots were the plant part highest in the total amount of lignans in common buckwheat, tartary buckwheat, and common millet; which is in ...
DOI:
10.1016/j.jfca.2021.104283

67. Distribution, biosynthesis and therapeutic potential of lignans

Author:
Navdeep Singh Plaha; Sumegha Awasthi; Ayushi Sharma; Nutan Kaushik
Source:
3 Biotech 2022 v.12 no.10 pp. 255
ISSN:
2190-572X
Subject:
anticarcinogenic agents; antioxidants; biosynthesis; gene expression regulation; intestinal microorganisms; lignans; linseed; mammals; therapeutics; toxicity
Abstract:
... Lignans have long been known for their abundant therapeutic properties due to their polyphenolic structure. Linseed is the richest plant source of lignans and has been studied widely for their properties. The most prevalent lignan, secoisolariciresinol diglucoside (SDG), is consumed with linseed and converted into mammalian lignans, enterodiol (END) and enterolactone (ENL), by the gut microbiota. ...
DOI:
10.1007/s13205-022-03318-9

68. Dolominol a and B, two new neolignans from Dolomiaea souliei (Franch.) C.Shih

Author:
Man Yi; Fan-Cheng Meng; Shen-Yue Qu; Jing-Xin Mao; Guowei Wang; Mingxing Liu; Zhi-Hua Liao; Min Chen
Source:
Natural product research 2022 v.36 no.15 pp. 3909-3916
ISSN:
1478-6427
Subject:
alcohols; hepatoprotective effect; lignans; research
Abstract:
... Two new neolignans, dolominol A (1) and dolominol B (2), together with 12 known lignans, erythro-(7S,8R)-guaiacyl-glycerol-β-O-4′-dihydroconiferyl ether (3), threo-(7R,​8R)-1-​(4-​hydroxy-​3-​methoxyphenyl)​-​2-{4-[(E)-​3-​hydroxy-​1-​propen​yl)​]-​2-​methoxyphenoxy}-1,​3-​propanediol (4), (-)-dihydrodehydrodiconiferyl alcohol (5), (-)-massoniresinol (6), vladinol D (7), syringaresinol (8), prinse ...
DOI:
10.1080/14786419.2021.1897125

69. Effect of microwave exposure to flaxseed on the composition, structure and techno-functionality of gum polysaccharides

Author:
Xiao Yu; Shasha Huang; Fan Yang; Xiaopeng Qin; Chengzhen Nie; Qianchun Deng; Fenghong Huang; Qisen Xiang; Yingying Zhu; Fang Geng
Source:
Food hydrocolloids 2022 v.125 pp. 107447
ISSN:
0268-005X
Subject:
antioxidants; crosslinking; depolymerization; emulsions; enthalpy; gels; hydrocolloids; lignans; linseed; molecular weight; polysaccharides; seed coat; thermogravimetry; viscoelasticity
Abstract:
... The current study aimed to explore the potential influences of microwave exposure to flaxseed (150 g samples, 700 W for 1–5 min) on the several techno-functional properties of flaxseed gum (FG), focusing on the changes in composition, surface morphology and multiscale structure. The results showed that microwave exposure to flaxseed actually resulted in evident etching effect on seed coat and favo ...
DOI:
10.1016/j.foodhyd.2021.107447

70. Effect of soaked and fermented raspberry wines on the liver in mice

Author:
Xiaoxuan Jing; Nanhai Zhang; Liang Zhao; Jingxuan Zhou; Wei Wu; Liebing Zhang; Feng Zhou
Source:
Food bioscience 2022 v.47 pp. 101704
ISSN:
2212-4292
Subject:
anthocyanins; antioxidants; blood serum; chemical constituents of plants; cytokines; fermentation; fruits; lignans; lipids; liver; liver diseases; liver function; malondialdehyde; mice; polyphenols; raspberries; saponins; terpenoids; wines; China
Abstract:
... Evidence has shown that some dietary polyphenols (flavonoids, phenolic acids, tannins, lignans, saponins, terpenoids, etc.) can alleviate alcoholic liver disease (ALD). Raspberries, the fourth most significant fruit worldwide, comprise a particular phytochemical profile encompassing ellagitannins and anthocyanins and exert many biological activities. In contrast to Chinese liquor (named Baijiu in ...
DOI:
10.1016/j.fbio.2022.101704

71. Effect of ultrasonic pretreatment for lignan accumulation in flax sprouts (Linum usitatissimum L.)

Author:
Yixin Wu; Hong Wang; Fangyang Gao; Yufu Wang; Xinbo Guo; Caisheng Qiu
Source:
Food chemistry 2022 v.370 pp. 131067
ISSN:
0308-8146
Subject:
Linum usitatissimum; biosynthesis; caffeic acid; ferulic acid; flax; food chemistry; lignans; p-coumaric acid; ultrasonics; vegetables
Abstract:
... This study evaluated different ultrasonic treatments for lignan biosynthesis in two varieties of flax sprouts. Results showed that lignans in flax sprouts significantly raised with ultrasonic pretreatment. Secoisolariciresinol diglucoside dramatically increased by about 6-fold at the flax sprouts. Ultrasonic pretreatment could also affect the accumulation of caffeic acid and p-coumaric acid in fla ...
DOI:
10.1016/j.foodchem.2021.131067

72. Effective components and mechanism analysis of anti-platelet aggregation effect of Justicia procumbens L.

Author:
Bo Liu; Ting Zhang; Zhou-tao Xie; Zong-chao Hong; Yi Lu; Yu-meng Long; Chen-zi Ji; Ya-ting Liu; Yan-fang Yang; He-zhen Wu
Source:
Journal of ethnopharmacology 2022 v.294 pp. 115392
ISSN:
0378-8741
Subject:
Justicia procumbens; Oriental traditional medicine; blood stasis; carotid arteries; ferric chloride; fever; homeopathic drugs; humans; integrins; lignans; methyl ethers; mitogen-activated protein kinase; pain; platelet aggregation; thrombosis; India; Malaysia; Nepal
Abstract:
... Justicia procumbens L. is a traditional Chinese medicine, first recorded in "Shen Nong's Herbal Classic", for the treatment of lumbar pain and fever. As a widely distributed herb, it has also been documented in India, Nepal, and Malaysia. In “Tang Materia Medica”, a famous medicinal book of Tang Dynasty in ancient China, it was first used to treat diseases associated with blood stasis. Blood stasi ...
DOI:
10.1016/j.jep.2022.115392

73. Effects of dibenzylbutyrolactone lignans arctigenin and trachelogenin on the motility of isolated rat ileum

Author:
Peter Kiplang’at Koech; Imre Boldizsár; Arpád Dobolyi; Petra Varró
Source:
Toxicology reports 2022 v.9 pp. 1222-1232
ISSN:
2214-7500
Subject:
Arctium lappa; Cirsium arvense; adults; calcium; calcium channel blockers; calcium channels; dose response; gastrointestinal motility; ileum; lignans; males; mechanism of action; nitric oxide synthase; rats; toxicology
Abstract:
... Dibenzylbutyrolactone-type lignans are phenolic compounds of medical importance. The purpose of the study was to determine the effects of two such lignans, arctigenin and trachelogenin on the motility of isolated rat ileum and obtain indications on their mechanism of action. They were isolated from Arctium lappa and Cirsium arvense, respectively, which have been used traditionally to treat gastroi ...
DOI:
10.1016/j.toxrep.2022.05.019

74. Ethnomedicinal plants used for the treatment of neurodegenerative diseases in Himachal Pradesh, India in Western Himalaya

Author:
Kiran Sharma; Rachna Verma; Dinesh Kumar; Eugenie Nepovimova; Kamil Kuča; Ashwani Kumar; Disha Raghuvanshi; Rajni Dhalaria; Sunil Puri
Source:
Journal of ethnopharmacology 2022 v.293 pp. 115318
ISSN:
0378-8741
Subject:
anthocyanins; antioxidant activity; antioxidants; brain; coumarins; death; epilepsy; flavanols; flavones; health services; humans; isoflavones; lignans; nerve tissue; protective effect; rural population; traditional medicine; Himalayan region; India
Abstract:
... Medicinal plants are considered as a healthcare resource and widely used by rural people in their traditional medicine system for curing neurodegenerative diseases. Neurodegenerative diseases refer to incurable and debilitating conditions that result in progressive degeneration/death of nerve cells or neurons in the human brain. This review is mainly focused on the usage of different ethnomedicina ...
DOI:
10.1016/j.jep.2022.115318

75. Ethnopharmacology, phytochemistry, chemical ecology and invasion biology of Acanthus mollis L.

Author:
Nadire Özenver; Monika Efferth; Thomas Efferth
Source:
Journal of ethnopharmacology 2022 v.285 pp. 114833
ISSN:
0378-8741
Subject:
Acanthus mollis; anthraquinones; antioxidants; biodiversity; chemical ecology; environmental protection; extinction; flavonoids; gastrointestinal system; herbivores; humans; invasive species; lignans; mice; models; ornamental plants; phenylpropanoids; phytosterols; secondary metabolites; trade; traditional medicine; Argentina; Australia; China; Great Britain; India; New Zealand; Northern European region; South Africa
Abstract:
... Acanthus mollis L. (Bear's Breeches) is a wide-spread medicinal and ornamental plant and is particularly suited to exemplarily illustrate the diverse aspects of invasion biology by neophytes. Since ancient times, it has been a popular Mediterranean ornamental plant in horticulture and served as model for the decoration of column capitals in architecture.In the present review, we aimed to give an o ...
DOI:
10.1016/j.jep.2021.114833

76. Evolution of the metabolic profile of virgin olive oil during deep-frying: Assessing the transfer of bioactive compounds to the fried food

Author:
Aline Gabrielle Alves de Carvalho; Lucía Olmo-García; Bruna Rachel Antunes Gaspar; Alegría Carrasco-Pancorbo; Vanessa Naciuk Castelo-Branco; Alexandre Guedes Torres
Source:
Food chemistry 2022 v.380 pp. 132205
ISSN:
0308-8146
Subject:
deep fat frying; diodes; evolution; fluorescence; food chemistry; fried foods; lignans; liquid chromatography; mass spectrometry; metabolites; nutritive value; sterols; virgin olive oil; Brazil
Abstract:
... Deep-frying in virgin olive oil (VOO) is favorable due to its desirable composition and high content of bioactive compounds that can be transferred to fried food. The main goal of this work was to investigate the evolution of VOO metabolic profile during consecutive deep-frying cycles and assess the transfer of metabolites to French fries. The evolution of 56 compounds was monitored by two complem ...
DOI:
10.1016/j.foodchem.2022.132205

77. Exploring the active compounds and potential mechanism of the anti-nonalcoholic fatty liver disease activity of the fraction from Schisandra chinensis fruit extract fraction based on multi-technology integrated network pharmacology

Author:
Bin Li; Qi Xiao; Jianuo Zhang; Yumeng Wang; Jiushi Liu; Bengang Zhang; Haitao Liu
Source:
Journal of ethnopharmacology 2022 pp. 115769
ISSN:
0378-8741
Subject:
Oriental traditional medicine; Schisandra chinensis; active ingredients; alanine transaminase; aspartate transaminase; blood serum; cholesterol; ethanol; fatty liver; fruit extracts; fruits; gene expression; glucose tolerance; glucose tolerance tests; high fat diet; human cell lines; insulin; insulin resistance; insulin tolerance test; lignans; liver; malondialdehyde; mass spectrometry; mice; models; petroleum; pharmacology; reverse transcriptase polymerase chain reaction; triacylglycerols
Abstract:
... Schisandra chinensis fruit is a well-known traditional Chinese medicine (TCM) that has been used to treat various liver diseases. Our previous study revealed that its extract is effective against nonalcoholic fatty liver disease (NAFLD). This study aimed to elucidate the active components and explore the underlying mechanisms of action of S. chinensis fruit in the treatment of NAFLD. A HepG2 cell ...
DOI:
10.1016/j.jep.2022.115769

78. Exudates of Picea abies, Pinus nigra, and Larix decidua: Chromatographic Comparison and Pro-Migratory Effects on Keratinocytes In Vitro

Author:
Thomas Goels; Elisabeth Eichenauer; Ammar Tahir; Paul Prochaska; Franziska Hoeller; Elke H. Heiß; Sabine Glasl
Source:
Plants 2022 v.11 no.5 pp. -
ISSN:
2223-7747
Subject:
Betula; Larix decidua; Picea abies; Pinus nigra; diterpenoids; equipment; hydroxylation; keratinocytes; lignans; lysophospholipids; manuka honey
Abstract:
... Balms and resins of Picea abies, Larix decidua, and Pinus nigra are traditionally used to treat wounds. Three chromatographic techniques differing in separation capacity and technical demands were employed to distinguish among these plant exudates. A TLC method was established for fingerprint comparison, providing a quick overview of a large number of samples at low cost. HPLC-DAD (RP18) and UHPSF ...
DOI:
10.3390/plants11050599

79. Flavone, flavanone and flavonol metabolism from soybean and flaxseed extracts by the intestinal microbiota of adults and infants

Author:
José M Landete
Source:
Journal of the science of food and agriculture 2022 v.102 no.6 pp. 2575-2583
ISSN:
0022-5142
Subject:
adults; agriculture; antioxidant activity; apigenin; bioavailability; catabolism; catechol; flavanones; intestinal microorganisms; isoflavones; kaempferol; lignans; linseed; luteolin; myricetin; protocatechuic acid; quercetin; soybeans
Abstract:
... BACKGROUND: Flaxseed and soybean are an important source of lignans and flavonoids. Previously, the metabolism of isoflavones and lignans from soybean and flaxseed extracts by the microbiota of adult individuals (n = 14) and infants (n = 23) was analyzed. Thus, the present study aimed to examine the metabolism of flavones, flavanones and flavonols, as well as the production of phenolic acids, by t ...
DOI:
10.1002/jsfa.11599

80. Flavonoids of the Caryophyllaceae

Author:
Katarzyna Jakimiuk; Michael Wink; Michał Tomczyk
Source:
Phytochemistry reviews 2022 v.21 no.1 pp. 179-218
ISSN:
1568-7767
Subject:
Caryophyllaceae; antioxidants; flavonols; health promotion; isoflavones; lignans; phytoecdysteroids; polyphenols; saponins; secondary metabolites; temperate zones
Abstract:
... The plant family Caryophyllaceae, commonly known as the pink family, is divided into 3 subfamilies and contains over 80 genera with more than 2600 species that are widely distributed in temperate climate zones. Plants belonging to this family produce a variety of secondary metabolites important in an ecological context; however, some of these metabolites also show health-promoting activities. The ...
DOI:
10.1007/s11101-021-09755-3

81. Food and nutraceutical functions of sesame oil: An underutilized crop for nutritional and health benefits

Author:
Sapna Langyan; Pranjal Yadava; Sanjula Sharma; Navin Chandra Gupta; Ruchi Bansal; Rashmi Yadav; Sanjay Kalia; Ashok Kumar
Source:
Food chemistry 2022 v.389 pp. 132990
ISSN:
0308-8146
Subject:
dietary supplements; food chemistry; health promotion; human health; lignans; nutritive value; oilseed crops; phytosterols; sesame oil; tocopherols; vegetable oil; vegetables
Abstract:
... Sesame is the oldest oilseed crop known to humanity, though it contributes a small share in the global vegetable oil production. Sesame oil contains nutrients, including lignans, tocopherols, phytosterols, natural antioxidants, and bioactive compounds. It provides various health benefits such as anti-lipogenic, hypo-cholesterolemic, anti-degenerative, and neural health-promoting properties. Being ...
DOI:
10.1016/j.foodchem.2022.132990

82. Functional components of peanuts (Arachis Hypogaea L.) and health benefits: A review

Author:
S. Çiftçi; G. Suna
Source:
Future foods 2022 v.5 pp. 100140
ISSN:
2666-8335
Subject:
Arachis hypogaea; Mediterranean diet; diabetes; economic development; energy; human health; hypertension; isoflavonoids; lignans; models; oils; peanuts; people; phytosterols; stilbenes; South America; Virginia
Abstract:
... Peanut (Arachis hypogea L.) is one of the most consumed oil seeds worldwide. It belongs to the legume family and has spread to other parts of the world from South America. Peanut has been classified as Virginia, Runner, Spanish, and Valencia depending on the seed stagnation, branching pattern, the plant maturation period, and economic growth. People have consumed peanuts as raw, boiled, oil extrac ...
DOI:
10.1016/j.fufo.2022.100140

83. Genome-Wide Association Study Uncovers Loci and Candidate Genes Underlying Phytosterol Variation in Sesame (Sesamum indicum L.)

Author:
Zhijian Wang; Qi Zhou; Senouwa Segla Koffi Dossou; Rong Zhou; Yingzhong Zhao; Wangyi Zhou; Yanxin Zhang; Donghua Li; Jun You; Linhai Wang
Source:
Agriculture (Basel) 2022 v.12 no.3 pp. -
ISSN:
2077-0472
Subject:
Sesamum indicum; agriculture; campesterol; dietary supplements; gas chromatography; genes; genome-wide association study; lignans; oilseeds; single nucleotide polymorphism; stigmasterol
Abstract:
... Sesame is one of the most important oilseed crops grown worldwide. It provides diverse nutraceuticals—including lignans, unsaturated fatty acids (UFA), phytosterols, etc.—to humans. Among sesame’s nutraceuticals, phytosterols have received less attention from sesame breeders, although their biological and pharmacological functions have been recorded. Therefore, in the present study, we evaluated t ...
DOI:
10.3390/agriculture12030392

84. Genome-Wide Identification and Expression Analysis of Eggplant DIR Gene Family in Response to Biotic and Abiotic Stresses

Author:
Kaijing Zhang; Wujun Xing; Suao Sheng; Dekun Yang; Fengxian Zhen; Haikun Jiang; Congsheng Yan; Li Jia
Source:
Horticulturae 2022 v.8 no.8 pp. -
ISSN:
2311-7524
Subject:
Arabidopsis; bioinformatics; biosynthesis; eggplants; genes; lignans; lignin; pepper; phylogeny; rice
Abstract:
... Dirigent proteins (DIR) play important roles in the biosynthesis of lignins and lignans, defensive responses, secondary metabolism, and disease resistance in plants. The DIR gene family has been identified and studied in many plants. However, the identification of DIR gene family in eggplant has not been conducted yet. Therefore, in this study, based on the available genome information of eggplant ...
DOI:
10.3390/horticulturae8080732

85. Genome-wide analysis of codon usage in sesame (Sesamum indicum L.)

Author:
Mebeaselassie Andargie; Zhu Congyi
Source:
Heliyon 2022 v.8 no.1 pp. e08687
ISSN:
2405-8440
Subject:
Sesamum indicum; biosynthesis; codon usage; correspondence analysis; evolution; genome-wide association study; lignans; oil crops
Abstract:
... Sesamum indicum is an ancient oil crop grown in tropical and subtropical areas of the world. We have analyzed 23,538 coding sequences (CDS) of S. indicum to understand the factors shaping codon usage in this important oil crop plant. We identified eleven highly preferred codons in S. indicum that have AT-endings. The slope of a neutrality plot was less than one while effective number of codons (EN ...
DOI:
10.1016/j.heliyon.2021.e08687

86. Genome-wide identification and expression analysis of dirigent gene family in strawberry (Fragaria vesca) and functional characterization of FvDIR13

Author:
Yaqian Shi; Yaru Shen; Bilal Ahmad; Liping Yao; Tiannan He; Jianshuai Fan; Yuhan Liu; Qingxi Chen; Zhifeng Wen
Source:
Scientia horticulturae 2022 v.297 pp. 110913
ISSN:
0304-4238
Subject:
Arabidopsis thaliana; Fragaria vesca; Glomerella cingulata; bioinformatics; computer simulation; disease resistance; gene expression regulation; growth and development; introns; lignans; lignin; metabolism; pathogens; phylogeny; plant growth; plant response; stolons; strawberries
Abstract:
... Dirigent proteins (DIR) are thought to have important roles in lignans or lignin-like molecules production, defensive responses, secondary metabolism, and disease resistance in plants. There is a lack of information about the DIR genes in strawberries (Fragaria vesca). In this study, 33 FvDIR genes were identified and divided into four subfamilies based on the phylogenetic analysis. A detailed bio ...
DOI:
10.1016/j.scienta.2022.110913

87. Genus Gleditsia: A Phytochemical and Biological Review (2015-2020)

Author:
Hagar Ashraf; Ashaimaa Y. Moussa; Omayma A. Eldahshan; Abdel Nasser B Singab
Source:
Journal of Biologically Active Products from Nature 2022 v.12 no.1 pp. 1-23
ISSN:
2231-1874
Subject:
Gleditsia japonica; Gleditsia sinensis; Gleditsia triacanthos; Oriental traditional medicine; adhesion; analgesics; antioxidants; apoptosis; coumarins; cytotoxicity; flavonoids; interleukins; lignans; necrosis; neoplasms; prostaglandin synthase; prostaglandins; saponins
Abstract:
... Gleditsia species were widely used traditionally for the treatment of GIT problems and skin diseases, especially in Chinese traditional medicine. Gleditsia species isolated compounds and biological activities were summarized in a previous review published in 2015. This work aims to review the isolated chemical compounds from Gleditsia species and their biological activities during the period from ...
DOI:
10.1080/22311866.2021.2013943

88. Grandisin and its Therapeutic potential and Pharmacological Activities: a review

Author:
Dinesh Kumar Patel
Source:
Pharmacological research 2022 pp. 100176
ISSN:
2667-1425
Subject:
Aglaia; Cryptocarya; Oriental traditional medicine; Piper; Trypanosoma cruzi; Virola surinamensis; antioxidants; biotransformation; chemical constituents of plants; cytotoxicity; estrogens; humans; larvicides; lignans; metabolism; plant estrogens; polyphenols; research; tetrahydrofuran; therapeutics
Abstract:
... Plant derived products and phytoconstituents have been used in medicine for the treatment of human disorders and associated secondary complication since a very early age. Phytoconstituents have numerous biological potential and therapeutic benefits in medicine. Lignans are a kind of non-flavonoids polyphenols which can bind to the estrogen receptors and function as phytoestrogens. Lignans have ant ...
DOI:
10.1016/j.prmcm.2022.100176

89. Greater Consumption of Total and Individual Lignans and Dietary Fibers Were Significantly Associated with Lowered Risk of Hip Fracture—A 1:1 Matched Case–Control Study among Chinese Elderly Men and Women

Author:
Zhaomin Liu; Bailing Chen; Baolin Li; Cheng Wang; Guoyi Li; Wenting Cao; Fangfang Zeng; Yuming Chen
Source:
Nutrients 2022 v.14 no.5 pp. -
ISSN:
2072-6643
Subject:
case-control studies; dietary surveys; elderly; food frequency questionnaires; food intake; hip fractures; lignans; matairesinol; regression analysis; risk; risk reduction
Abstract:
... The study aims to examine the association of dietary intake of lignans with the risk of hip fractures in Chinese older adults. This was a 1:1 age- and gender- matched case–control study. Dietary survey was conducted by face-to-face interviews using a 79-item validated food frequency questionnaire. Habitual intake of total and individual lignans (matairesinol, secoisolariciresinol, pinoresinol, and ...
DOI:
10.3390/nu14051100

90. Guaiane-rich phytochemical profile of Centaurea kotschyi subsp. persica (Boiss.) Wagenitz and identification of hypoglycaemic metabolites

Author:
Elena Serino; Giuseppina Chianese; Giorgia Musto; Gökhan Zengin; Daniela Rigano; Mariano Stornaiuolo; Carmen Formisano; Orazio Taglialatela-Scafati
Source:
Phytochemistry 2022 v.199 pp. 113189
ISSN:
0031-9422
Subject:
Centaurea; chemical constituents of plants; glycemic effect; lignans; matairesinol; metabolites; monoterpenoids; sesquiterpenoid lactones; spectral analysis
Abstract:
... Phytochemical investigation of the aerial parts obtained from the Turkish plant Centaurea kotschyi subsp. persica led to the isolation of nine sesquiterpene lactones belonging to the guaiane class, including the undescribed kotschyols A and B, a monoterpene lactone (daphnauranin E), four known lignans (matairesinol, matairesinoside, arctiin and arctigenin) and an undescribed dihydrobenzofuran neol ...
DOI:
10.1016/j.phytochem.2022.113189

91. Hepatoprotective effect of phillygenin on carbon tetrachloride-induced liver fibrosis and its effects on short chain fatty acid and bile acid metabolism

Author:
Cheng Wang; Cheng Ma; Ke Fu; Yanfang Liu; Lihong Gong; Cheng Peng; Yunxia Li
Source:
Journal of ethnopharmacology 2022 v.296 pp. 115478
ISSN:
0378-8741
Subject:
Forsythia suspensa; Oriental traditional medicine; acetic acid; antioxidants; bile acids; butyric acid; carbon; carbon tetrachloride; dried fruit; epithelium; gas chromatography-mass spectrometry; hepatoprotective effect; immunohistochemistry; inflammation; intestinal microorganisms; intestines; intraperitoneal injection; lignans; liquid chromatography; liver; liver cirrhosis; metabolism; metabolomics; mice; models; olive oil; propionic acid; quantitative polymerase chain reaction
Abstract:
... Forsythiae fructus, the dried fruit of Oleaceae plant Forsythia suspensa (Thunb.) Vahl, is a traditional Chinese medicine widely used in clinical practice and has a variety of pharmacological activities, such as anti-inflammation, antioxidation, and hepatoprotection. Phillygenin (PHI), an important fingerprint lignan component of Forsythiae fructus, has prominent hepatoprotective, anti-inflammator ...
DOI:
10.1016/j.jep.2022.115478

92. Highly efficient separation and enrichment of polyphenols by 6-aminopyridine-3-boronic acid-functionalized magnetic nanoparticles assisted by polyethylenimine

Author:
Yansong Zhang; Lianglei Qing; Linna Xu
Source:
RSC advances 2022 v.12 no.11 pp. 6881-6887
ISSN:
2046-2069
Subject:
antioxidants; boronic acids; flavonoids; fruit juices; immunosuppressive agents; ligands; lignans; magnetism; mutants; pH; polyethyleneimine; polyphenols; purification methods; stilbenes; tea; therapeutics; water solubility
Abstract:
... Polyphenols have found a lot of therapeutic effects and potential applications such as antioxidant, anti-inflammatory, mutant resistance, immunosuppressant and anti-tumor properties. They can be divided into five main classes, namely flavonoids, phenolic acids, stilbenes, lignans, and others. Thus, the content detection of polyphenols in real samples such as fruit juice and tea is of great signifi ...
DOI:
10.1039/d1ra08751g

93. Identification and Quantification of Urinary Microbial Phenolic Metabolites by HPLC-ESI-LTQ-Orbitrap-HRMS and Their Relationship with Dietary Polyphenols in Adolescents

Author:
Emily P. Laveriano-Santos; María Marhuenda-Muñoz; Anna Vallverdú-Queralt; Miriam Martínez-Huélamo; Anna Tresserra-Rimbau; Elefterios Miliarakis; Camila Arancibia-Riveros; Olga Jáuregui; Ana María Ruiz-León; Sara Castro-Baquero; Ramón Estruch; Patricia Bodega; Mercedes de Miguel; Amaya de Cos-Gandoy; Jesús Martínez-Gómez; Gloria Santos-Beneit; Juan M. Fernández-Alvira; Rodrigo Fernández-Jiménez; Rosa M. Lamuela-Raventós
Source:
Antioxidants 2022 v.11 no.6 pp. -
ISSN:
2076-3921
Subject:
adolescents; biomarkers; detection limit; flavonoids; lignans; mass spectrometry; metabolites; polyphenols; quantitative analysis; stilbenes; urine
Abstract:
... This study aimed to develop and validate a liquid chromatography/electrospray ionization-linear ion trap quadrupole-Orbitrap-high-resolution mass spectrometry (HPLC/ESI-LTQ-Orbitrap-HRMS) method to identify and quantify urinary microbial phenolic metabolites (MPM), as well as to explore the relationship between MPM and dietary (poly)phenols in Spanish adolescents. A total of 601 spot urine samples ...
DOI:
10.3390/antiox11061167

94. Identification and Spatial Distribution of Bioactive Compounds in Seeds Vigna unguiculata (L.) Walp. by Laser Microscopy and Tandem Mass Spectrometry

Author:
Mayya P. Razgonova; Marina O. Burlyaeva; Yulia N. Zinchenko; Ekaterina A. Krylova; Olga A. Chunikhina; Natalia M. Ivanova; Alexander M. Zakharenko; Kirill S. Golokhvast
Source:
Plants 2022 v.11 no.16 pp. -
ISSN:
2223-7747
Subject:
Vigna unguiculata; anthocyanidins; carotenoids; cultivars; flavanols; flavonols; lignans; liquid chromatography; metabolomics; microscopy; sapogenins; seed coat; tandem mass spectrometry; vegetables; China
Abstract:
... The research presents a comparative metabolomic study of extracts of Vigna unguiculata seed samples from the collection of the N.I. Vavilov All-Russian Institute of Plant Genetic Resources. Analyzed samples related to different areas of use in agricultural production, belonging to different cultivar groups sesquipedalis (vegetable accessions) and unguiculata (grain accessions). Metabolome analysis ...
DOI:
10.3390/plants11162147

95. Identification and characterization of anthocyanins and non-anthocyanin phenolics from Australian native fruits and their antioxidant, antidiabetic, and anti-Alzheimer potential

Author:
Akhtar Ali; Jeremy J. Cottrell; Frank R. Dunshea
Source:
Food research international 2022 pp. 111951
ISSN:
0963-9969
Subject:
acetylcholinesterase; anthocyanins; antioxidants; food research; human health; lignans; metabolites; peaches; plums; proanthocyanidins; stilbenes; terpenoids
Abstract:
... Polyphenols are vital bioactive constituents that have beneficial effects on human health. The aim of this study was to characterize the biologically active phenolic metabolites in Australian native commercial fruits (Kakadu plum, Davidson’s plum, quandong peach, and muntries) and their antioxidant, α-glucosidase, and acetylcholinesterase inhibition activities. Polyphenols were measured through to ...
DOI:
10.1016/j.foodres.2022.111951

96. Immunomodulatory and anti-inflammatory effects of sesamin: mechanisms of action and future directions

Author:
Amin F. Majdalawieh; Sarah M. Yousef; Imad A. Abu-Yousef; Gheyath K. Nasrallah
Source:
Critical reviews in food science and nutrition 2022 v.62 no.18 pp. 5081-5112
ISSN:
1549-7852
Subject:
Sesamum indicum; absorption; anti-inflammatory activity; atherosclerosis; bioavailability; cytotoxicity; diabetes mellitus; food science; inflammation; lignans; nutrition; oils; pharmacokinetics; signal transduction; therapeutics; tissue distribution
Abstract:
... Inflammation is associated with the development and progression of various disorders including atherosclerosis, diabetes mellitus and cancer. Sesamin, a fat-soluble lignan derived from Sesamum indicum seeds and oil, has received increased attention due to its wide array of pharmacological properties including its immunomodulatory and anti-inflammatory potential. To date, no review has been conduct ...
DOI:
10.1080/10408398.2021.1881438

97. In vitro and in silico studies of SARS-CoV-2 main protease Mᵖʳᵒ inhibitors isolated from Helichrysum bracteatum

Author:
Gehad Abdel Wahab; Walaa S. Aboelmaaty; Mohamed Farid Lahloub; Amal Sallam
Source:
RSC advances 2022 v.12 no.29 pp. 18412-18424
ISSN:
2046-2069
Subject:
Severe acute respiratory syndrome coronavirus 2; Xerochrysum bracteatum; computer simulation; energy transfer; flavanones; flavones; fluorescence; lignans; linoleic acid; moieties; phenylpropanoids; propane; proteinases; spectroscopy; therapeutics
Abstract:
... Discovering SARS-CoV-2 inhibitors from natural sources is still a target that has captured the interest of many researchers. In this study, the compounds (1–18) present in the methanolic extract of Helichrysum bracteatum were isolated, identified, and their in vitro inhibitory activities against SARS-CoV-2 main protease (Mᵖʳᵒ) was evaluated using fluorescence resonance energy transfer assay (FRET- ...
DOI:
10.1039/d2ra01213h

98. In vitro bioaccessibility of phenolic compounds and alpha-glucosidase inhibition activity in yoghurts enriched with mango peel powder

Author:
Hafza Fasiha Zahid; Akhtar Ali; Chaminda Senaka Ranadheera; Zhongxiang Fang; Frank R. Dunshea; Said Ajlouni
Source:
Food bioscience 2022 v.50 pp. 102011
ISSN:
2212-4292
Subject:
alkylphenols; alpha-glucosidase; bioavailability; coumarins; digestion; flavonoids; functional foods; hydroxybenzaldehyde; intestines; lignans; mango peels; metabolites; polyphenols; probiotics; stilbenes; xanthones; yogurt
Abstract:
... This study investigated the potential health benefits and functional properties of mango peel powder (MPP) as a source of antioxidants and alpha-glucosidase inhibitors in yoghurts with probiotic bacteria. The study involved plain yoghurt (PY, control), yoghurt fortified with 2% mango peel powder (MY), and yoghurt fortified with 2% MPP and 1% of each probiotic culture of L. casei, L. rhamnosus, B. ...
DOI:
10.1016/j.fbio.2022.102011

99. In vitro cytotoxic activity-guided isolation studies on the underground parts of Valeriana speluncaria Boiss.

Author:
Murat Erdoğan; Başak Aru; Ceren Öztürk; Olcay Esin Özdemir; Erdem Yeşilada; Gülderen Yanıkkaya-Demirel; Hasan Kırmızıbekmez
Source:
South African journal of botany 2022 v.149 pp. 315-319
ISSN:
0254-6299
Subject:
Valeriana; cell lines; cytotoxicity; ethyl acetate; fractionation; glucosides; indigenous species; lignans; neoplasm cells; nuclear magnetic resonance spectroscopy; phytochemicals
Abstract:
... Two unreported neolignans, speluncarins A (1) and B (2) together with seven known compounds (3–8, 13) were isolated from the underground parts of Valeriana speluncaria Boiss through cytotoxic activity-guided fractionation method. The crude extract, subextracts, main fractions and isolates were evaluated for their in vitro cytotoxic activities against MCF-7 and U87 cancer cell lines as well as HUVE ...
DOI:
10.1016/j.sajb.2022.06.024

100. In vivo schistosomicidal activity of (±)-licarin A-loaded poly(ε-caprolactone) nanoparticles

Author:
Thais C. Lima; Lizandra G. Magalhães; Lucas A. de L. Paula; Wilson R. Cunha; Ana H. Januário; Patricia M. Pauletti; Jairo K. Bastos; Hallana Alves Mnuquian; Moacir R. Forim; Raquel P. Morais-Urano; Rosangela S. Laurentiz; Wellington N. Tondato; Eduardo F. Molina; Mario F.C. Santos; Márcio L.A. e Silva
Source:
Experimental parasitology 2022 v.241 pp. 108357
ISSN:
0014-4894
Subject:
Schistosoma mansoni; drug therapy; lignans; nanoparticles; parasitology; praziquantel; schistosomiasis mansoni
Abstract:
... Schistosomiasis mansoni is an infectious parasitic disease caused by worms of the genus Schistosoma, and praziquantel (PZQ) is the medication available for the treatment of schistosomiasis. However, the existence of resistant strains reinforces the need to develop new schistosomicidal drugs safely and effectively. Thus, the (±)-licarin A neolignan incorporated into poly-Ɛ-caprolactone (PCL) nanopa ...
DOI:
10.1016/j.exppara.2022.108357