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1. Milk Calcium Taken with Cheese Increases Bone Mineral Density and Bone Strength in Growing Rats

Author:
Ken KATO; Yukihiro TAKADA; Hiroaki MATSUYAMA; Yoshihiro KAWASAKI; Seiichiro AOE; Hideo YANO; Yasuhiro TOBA
Source:
Bioscience, biotechnology, and biochemistry 2002 v.66 no.11 pp. 2342-2346
ISSN:
1347-6947
Subject:
bioavailability; biotechnology; bone density; bone strength; calcium; cheeses; energy; femur; lumbar spine; males; milk; osteoporosis
Abstract:
... We investigated the calcium bioavailability of milk calcium, taken with or without cheese. Twenty-four 6-week-old male rats for a meal-feeding experiment were trained to consume an AIN-76 diet within 2 h (2 times per day) for 2 weeks. The rats were then divided into three experimental groups, each fed 2 types of experimental diets: Control group, Cheese group, and Ca-Cheese group. The rats were ea ...
DOI:
10.1271/bbb.66.2342

2. Effects of Voluntary Resistance Exercise and High-protein Snack on Bone Mass, Composition, and Strength in Rats Given Glucocorticoid Injections

Author:
Tatsuhiro MATSUO; Tsutomu NOZAKI; Koji OKAMURA; Keitaro MATSUMOTO; Tatsuya DOI; Shoich GOHTANI; Masashige SUZUKI
Source:
Bioscience, biotechnology, and biochemistry 2003 v.67 no.12 pp. 2518-2523
ISSN:
1347-6947
Subject:
biotechnology; bone density; cages; calcium; energy; glucocorticoids; males; models; osteopenia; osteoporosis; protein content; protein intake; strength training; therapeutics; weight gain
Abstract:
... We examined the effects of a voluntary resistance exercise (climbing) together with high-protein snacks (60% protein) on bone mass and strength in rats given glucocorticoid-injections (2 mg/kg/day) as a model of age-related osteopenia. Fifty-two male Sprague-Dawley rats, 8 weeks age, were assigned to exercise or sedentary groups. These groups were further divided into groups that received no snack ...
DOI:
10.1271/bbb.67.2518

3. Citrus juice modulates bone strength in male senescent rat model of osteoporosis

Author:
Deyhim, F.; Garcia, K.; Lopez, E.; Gonzalez, J.; Ino, S.; Garcia, M.; Patil, B.S.
Source:
Nutrition 2006 v.22 no.5 pp. 559-563
ISSN:
0899-9007
Subject:
bone metabolism; disease prevention; males; orange juice; bone density; animal models; osteoporosis; rats; Citrus; antioxidant activity; bone strength; grapefruit juice; antioxidants; oxidative stress
DOI:
10.1016/j.nut.2005.12.002
PubMed:
16472977

4. The Impact of Nutrient Density, Feed Form, and Photoperiod on the Walking Ability and Skeletal Quality of Broiler Chickens

Author:
Brickett, K.E.; Dahiya, J.P.; Classen, H.L.; Annett, C.B.; Gomis, S.
Source:
Poultry science 2007 v.86 no.10 pp. 2117-2125
ISSN:
0032-5791
Subject:
broiler chickens; locomotion; mash feed; females; body weight; animal welfare; males; gender differences; nutrient density; pelleted feeds; bone density; walking; photoperiod; skeleton; gait; broiler feeding; bone strength
Abstract:
... The aim of this study was to examine the main and interaction effects of 3 dietary nutrient densities (low-, medium-, high-density), 2 feed forms (mash, pellet), and 2 lighting programs (20L:4D, 12L:12D) on the walking ability and skeletal quality of broiler chickens raised to a young age (35 d). Forty-eight birds per treatment (nutrient density x feed form x lighting program subclass) were random ...
DOI:
10.1093/ps/86.10.2117
PubMed:
17878440

5. The effect of maternal nutrient restriction during late gestation on muscle, bone and meat parameters in five month old lambs

Author:
Tygesen, M.P.; Harrison, A.P.; Therkildsen, M.
Source:
Livestock science 2007 v.110 no.3 pp. 230-241
ISSN:
1878-0490
Subject:
skeletal development; nutrient content; restricted feeding; lamb meat; meat production; animal growth; paternal effect; males; pregnancy; bone density; muscle tissues; maternal nutrition; lambs; ewes; compensatory growth; meat tenderness; animal breeding; bone strength; animal genetics
DOI:
10.1016/j.livsci.2006.11.003

6. Changes in bone mass, biomechanical properties, and microarchitecture of calcium- and iron-deficient rats fed diets supplemented with inulin-type fructans

Author:
Lobo, Alexandre R.; Cocato, Maria Lucia; Jorgetti, Vanda; de Sá, Lílian R.M.; Nakano, Eduardo Y.; Colli, Célia
Source:
Nutrition research 2009 v.29 no.12 pp. 873-881
ISSN:
0271-5317
Subject:
bone density; bone mineralization; transferrin; males; binding proteins; bone strength; microstructure; dietary fiber; blood serum; tibia; calcium; nutrient deficiencies; histology; iron deficiency anemia; rats; inulin; bone resorption; heme iron; osteoclasts; liver; mineral metabolism; nutritional status; experimental diets; nutrient availability; hemoglobin; magnesium; animal models
Abstract:
... Feeding mineral-deficient diets enhances absorptive efficiency as an attempt of the body to compensate for the lack of an essential nutrient. Under certain circumstances, it does not succeed; and nutritional deficiency is produced. Our hypothesis was that inulin-type fructans (ITF), which are known to affect mineral absorption, could increase Ca and Fe bioavailability in Ca- and Fe-deficient rats. ...
DOI:
10.1016/j.nutres.2009.10.012
PubMed:
19963161

7. Feeding Orange Pulp Improved Bone Quality in a Rat Model of Male Osteoporosis

Author:
Morrow, Rori; Deyhim, Farzad; Patil, Bhimanagouda S.; Stoecker, Barbara J.
Source:
Journal of medicinal food 2009 v.12 no.2 pp. 298-303
ISSN:
1096-620X
Subject:
citrus pulp; oranges; functional foods; osteoporosis; rats; animal models; males; oxidative stress; inflammation; ascorbic acid; flavonoids; bone density; feed intake; computed tomography; bone strength; tibia; urine; volume; bone resorption; microstructure; testosterone
DOI:
10.1089/jmf.2008.0145
PubMed:
19459729

8. Neonatal Administration of Isoflavones Attenuates Deterioration of Bone Tissue in Female but Not Male Mice

Author:
Kaludjerovic, Jovana; Ward, Wendy E.
Source:
Journal of nutrition 2010 v.140 no.4 pp. 766-772
ISSN:
0022-3166
Subject:
microstructure; soybean products; vertebrae; males; gender differences; ovariectomy; mice; bone density; genistein; animal models; castration; femur; daidzein; neonates; infant formulas; bone mineralization; bone strength; females; diethylstilbestrol
Abstract:
... Neonatal exposure to soy isoflavones at levels similar to that of infants fed soy protein formula resulted in higher bone mineral density (BMD), improved bone structure, and greater bone strength at young adulthood in female CD-1 mice (1,2). Our objective in this study was to determine whether these improvements in bone quantity and quality at 4 mo of age provide protection against the deteriorati ...
DOI:
10.3945/jn.109.116343
PubMed:
20164370

9. Supplementation with green tea polyphenols improves bone microstructure and quality in aged, orchidectomized rats

Author:
Chwan-Li Shen; Jay J. Cao; Raul Y. Dagda; Thomas E. Tenner Jr.; Ming-Chien Chyu; James K. Yeh
Source:
Calcified Tissue International 2011 v.88 no.6 pp. 455-463
ISSN:
0171-967X
Subject:
animal disease models; antioxidant activity; blood serum; bone density; bone formation; bone resorption; bone strength; castration; dietary supplements; elderly; enzyme activity; euthanasia; females; femur; glutathione peroxidase; green tea; liver; males; microstructure; osteoporosis; ovariectomy; polyphenols; postmenopause; rats; testosterone; tibia
Abstract:
... Recent studies show that green tea polyphenols (GTP) attenuate bone loss and microstructure deterioration in ovariectomized aged female rats, a model of postmenopausal osteoporosis. However, it is not known if such an osteo-protective role of GTP is demonstrable in androgen-deficient aged rats, a model of male osteoporosis. We evaluated the efficacy of GTP in mitigation of bone loss and microstruc ...
Handle:
10113/58159
DOI:
10.1007/s00223-011-9477-1
PubMed:
21431364

10. Influences of dietary vitamin D restriction on bone strength, body composition and muscle in rats fed a high-fat diet: involvement of mRNA expression of MyoD in skeletal muscle

Author:
Yuno Oku; Rieko Tanabe; Kanae Nakaoka; Asako Yamada; Seiko Noda; Ayumi Hoshino; Mayu Haraikawa; Masae Goseki-Sone
Source:
Journal of nutritional biochemistry 2016 v.32 pp. 85-90
ISSN:
0955-2863
Subject:
bone density; bone metabolism; bone strength; experimental diets; femur; gene expression; high fat diet; males; messenger RNA; muscles; osteoporosis; rats; risk; sarcopenia; skeletal muscle; transcription factors; visceral fat; vitamin D
Abstract:
... Vitamin D insufficiency is associated with a greater risk of osteoporosis and also influences skeletal muscle functions, differentiation and development. The present study investigated the influences of vitamin D restriction on the body composition, bone and skeletal muscle in rats fed a high-fat diet. Sprague–Dawley strain male rats (11weeks old) were divided into four groups and fed experimental ...
DOI:
10.1016/j.jnutbio.2016.01.013

11. Skeletal site-specific effects of endurance running on structure and strength of tibia, lumbar vertebrae, and mandible in male Sprague–Dawley rats

Author:
Kirsten N. Bott; Sandra M. Sacco; Patrick C. Turnbull; Amanda B. Longo; Wendy E. Ward; Sandra J. Peters
Source:
Applied Physiology, Nutrition, and Metabolism 2016 v.41 no.6 pp. 597-604
ISSN:
1715-5320
Subject:
bone density; bone strength; dual-energy X-ray absorptiometry; food intake; males; mandible (bone); mastication; materials testing; metabolism; micro-computed tomography; rats; skeleton; tibia; vertebrae
Abstract:
... Bone microarchitecture, bone mineral density (BMD), and bone strength are affected positively by impact activities such as running; however, there are discrepancies in the magnitude of these effects. These inconsistencies are mainly a result of varying training protocols, analysis techniques, and whether or not the skeletal sites measured are weight bearing. This study’s purpose was to determine t ...
DOI:
10.1139/apnm-2015-0404

12. Dietary non-phytate phosphorus requirement of broilers fed a conventional corn-soybean meal diet from 1 to 21 d of age

Author:
S.B. Liu; X.D. Liao; L. Lu; S.F. Li; L. Wang; L.Y. Zhang; Y. Jiang; X.G. Luo
Source:
Poultry science 2017 v.96 no.1 pp. 151-159
ISSN:
0032-5791
Subject:
blood serum; bone density; bone strength; cages; calcium; calcium hydrogen phosphate; diet; duodenum; gene expression; genes; growth performance; inorganic phosphorus; males; sodium phosphate; symporters; tibia; weight gain
Abstract:
... An experiment was conducted to investigate the effect of dietary non-phytate phosphorus (NPP) level on growth performance, bone characteristics and phosphorus metabolism-related gene expressions, so as to evaluate the dietary NPP requirement of broiler chicks fed a conventional corn-soybean meal diet from 1 to 21 d of age. A total of 540 day-old Arbor Acres male chicks were randomly allocated to o ...
DOI:
10.3382/ps/pew212

13. Influence of gait on bone strength in turkeys with leg defects

Author:
E.O. Oviedo-Rondón; P.L. Mente; C. Arellano; B.D.X. Lascelles; A. Mitchell
Source:
Poultry science 2018 v.97 no.8 pp. 2621-2637
ISSN:
0032-5791
Subject:
Large White; analysis of variance; asymmetry; biomechanics; bone density; bone strength; dual-energy X-ray absorptiometry; femur; gait; legs; males; tibia; toms
Abstract:
... Leg problems have become more frequent in fast-growing turkeys. The objective of this study was to evaluate the effects of common leg defects on kinetic parameters of gait and biomechanical properties of bone. Nine hundred, day-old, male, Large White turkeys were raised in 48 floor pens. At 42 d of age, turkeys were divided into four categories of leg condition as determined by visual evaluation: ...
DOI:
10.3382/ps/pey142

14. Arachidonic acid exacerbates diet-induced obesity and reduces bone mineral content without impacting bone strength in growing male rats

Author:
Ivy L Mak; Paula Lavery; Sherry Agellon; Frank Rauch; Monzur Murshed; Hope A Weiler
Source:
Journal of nutritional biochemistry 2019 v.73 pp. 108226
ISSN:
0955-2863
Subject:
adipocytes; adiposity; analysis of variance; arachidonic acid; blood serum; bone density; bone resorption; bone strength; dual-energy X-ray absorptiometry; energy intake; erythrocytes; fatty acid composition; femur; gas chromatography; high fat diet; laboratory animals; leptin; long chain polyunsaturated fatty acids; males; metabolism; micro-computed tomography; mineral content; obesity; rats; visceral fat
Abstract:
... Long-chain polyunsaturated fatty acids modulate bone mass and adipocyte metabolism. Arachidonic acid (AA, C20:4 n-6) is elevated in obesity and postulated to stimulate bone resorption. This study aimed to determine the effect of AA on bone mass, quality, and adiposity in diet-induced obesity during growth. Male Sprague–Dawley rats (n=42, 4-week) were randomized into groups fed a control diet (CTRL ...
DOI:
10.1016/j.jnutbio.2019.108226

15. Effects of dietary calcium and phosphorus levels and supplementation of 25-hydroxycholecalciferol on performance and bone properties of broiler starters

Author:
Lianhua Zhang; Tengfei He; Miao Li; Jiangxu Hu; Xiangshu Piao
Source:
Archives of animal nutrition 2019 v.73 no.6 pp. 445-456
ISSN:
1477-2817
Subject:
25-hydroxycholecalciferol; ash content; biomechanics; blood serum; bone density; broiler chickens; broiler feeding; calcium; diet; energy; femur; growth performance; hydroxyproline; males; phosphorus; tibia
Abstract:
... To investigate effects of dietary calcium (Ca) and phosphorus (P) levels and 25-hydroxycholecalciferol (25OHD₃) supplementation on performance and bone properties of broiler starters, 224 male Arbor Acre broilers were used in a 21-d trial. Broilers were allotted to one of four treatments in a 2 × 2 factorial arrangement including diets either normal or low in Ca and P, which were further supplemen ...
DOI:
10.1080/1745039X.2019.1667192

16. Evaluation of the effect of CaD on the bone structure and bone metabolic changes in senile osteoporosis rats based on MLP–ANN methods

Author:
Xiufeng Tang; Yingying Gao; Yuheng Chen; Xiaoxi Li; Ping Yu; Zitong Ma; Renhui Liu
Source:
Food & function 2019 v.10 no.12 pp. 8026-8041
ISSN:
2042-650X
Subject:
Western blotting; acid phosphatase; alkaline phosphatase; biomechanics; blood serum; bone density; bone metabolism; bone strength; calcium; cholecalciferol; drugs; fluorescent antibody technique; insulin-like growth factor I; laboratory animals; macrophage colony-stimulating factor; males; messenger RNA; micro-computed tomography; microstructure; models; osteoporosis; pathogenesis; protein synthesis; quantitative polymerase chain reaction; rats; reverse transcriptase polymerase chain reaction; tibia; transforming growth factor beta 1
Abstract:
... Senile osteoporosis (SOP) is a related disease of systematic degenerative changes in bones during natural aging. Increasing age is an important factor in its pathogenesis. This experiment was to evaluate the comprehensive effect of calcium with vitamin D3 (CaD) on SOP based on multilayer perception (MLP)–artificial neural network (ANN) methods. 15-month-old male Sprague-Dawley rats were administer ...
DOI:
10.1039/c9fo01322a

17. Therapeutic Effect of Strontium Ranelate on Bone in Chemotherapy-Induced Osteopenic Rats via Increased Bone Volume and Reduced Bone Loss

Author:
Yi Pei; Ke Zheng; GuanNing Shang; YuMing Wang; Wei Wang; EnDuo Qiu; ShenLong Li; XiaoJing Zhang
Source:
Biological trace element research 2019 v.187 no.2 pp. 472-481
ISSN:
0163-4984
Subject:
acid phosphatase; alkaline phosphatase; animal models; biomechanics; blood sampling; blood serum; bone density; bone formation; bone resorption; bone strength; calcium; cyclophosphamide; diet; intravenous injection; laboratory animals; males; micro-computed tomography; osteoblasts; osteoclasts; osteopenia; osteoporosis; phosphates; rats; strontium; tibia
Abstract:
... The purpose of this study was to determine whether treatment with strontium ranelate (SrR) can restore bone mass and strength at a skeletal site with established osteopenia in chemotherapy-induced rats. Forty-five Sprague-Dawley male rats were randomly assigned to three study groups (n = 15 rats per group): normal rats (control group), osteopenic rats (chemo group), and osteopenic rats with SrR (c ...
DOI:
10.1007/s12011-018-1401-3

18. Effects of alpha-lipoic acid on the behavior, serum indicators, and bone quality of broilers under stocking density stress

Author:
Huihui Ma; Bin Xu; Wenjia Li; Fengxian Wei; Woo Kyun Kim; Chongxiao Chen; Quanyou Sun; Chen Fu; Gaili Wang; Shaoyu Li
Source:
Poultry science 2020 v.99 no.10 pp. 4653-4661
ISSN:
0032-5791
Subject:
alkaline phosphatase; antioxidant activity; blood serum; bone density; bone strength; broiler chickens; calcium; catalase; corticosterone; dietary supplements; enzyme activity; femur; glutathione peroxidase; heterophils; ingestion; lipoic acid; males; malondialdehyde; oxidants; oxidative stress; parathyroid hormone; physiological response; preening; stocking rate; superoxide dismutase; tibia; walking
Abstract:
... The objective of present study was to investigate the effects of alpha-lipoic acid (ALA) dietary supplementation on the behavior, physiological and oxidant stress indicators, and bone quality in broilers under high stocking density (HSD) stress. A total of one thousand eight hundred 22-day-old Arbor Acres male broiler chicks were randomly allocated to 18 pens (2.97 × 2.03 m) in 3 groups: 14 birds/ ...
DOI:
10.1016/j.psj.2020.05.007

19. Vaspin antagonizes high fat-induced bone loss in rats and promotes osteoblastic differentiation in primary rat osteoblasts through Smad-Runx2 signaling pathway

Author:
Hongwei Wang; Fulian Chen; Jiaxuan Li; Yan Wang; Chunyan Jiang; Mengqi Zhang; Jin Xu
Source:
Nutrition & metabolism 2020 v.17 no.1 pp. 9
ISSN:
1743-7075
Subject:
alkaline phosphatase; animal disease models; biomechanics; bone density; bone formation; bone resorption; bone strength; collagen; dose response; gene expression; gene expression regulation; genes; high fat diet; in vitro studies; laboratory animals; males; messenger RNA; microstructure; obesity; osteoblasts; peptides; protein synthesis; proteinase inhibitors; rats; serine proteinases; signal transduction; transcription factors
Abstract:
... BACKGROUND: Visceral adipose tissue-derived serine protease inhibitor (vaspin), an adipose-derived hormone, exhibits various biological functions. Recently, studies showed that vaspin is closely related to bone metabolism. However, how vaspin influences bone formation and its underlying mechanisms in high fat-induced obese rats and rat primary osteoblasts (OBs) are not fully understood. In this st ...
DOI:
10.1186/s12986-020-0429-5
PubMed:
31993071
PubMed Central:
PMC6977231

20. Programming Effect of the Parental Obesity on the Skeletal System of Offspring at Weaning Day

Author:
Radoslaw Piotr Radzki; Marek Bienko; Dariusz Wolski; Monika Ostapiuk; Pawel Polak; Malgorzata Manastyrska; Aleksandra Kimicka; Joanna Wolska
Source:
Animals 2021 v.11 no.2 pp. -
ISSN:
2076-2615
Subject:
blood serum; bone density; bone metabolism; bone strength; dual-energy X-ray absorptiometry; females; high energy diet; males; micro-computed tomography; mineralization; obesity; progeny; rats; strength (mechanics); tibia
Abstract:
... Our study aimed to verify the hypothesis of the existence of a programming effect of parental obesity on the growth, development and mineralization of the skeletal system in female and male rat offspring on the day of weaning. The study began with the induction of obesity in female and male rats of the parental generation, using a high-energy diet (group F). Females and males of the control group ...
DOI:
10.3390/ani11020424

21. Effects of 12 Months Consumption of 100 g Dried Plum (Prunes) on Bone Biomarkers, Density, and Strength in Men

Author:
Shirin Hooshmand; Danielle Gaffen; Ashley Eisner; Jonnatan Fajardo; Mark Payton; Mark Kern
Source:
Journal of medicinal food 2022 v.25 no.1 pp. 40-47
ISSN:
1557-7600
Subject:
alkaline phosphatase; biomarkers; blood; bone density; bone health; bone strength; collagen; computed tomography; diet; dual-energy X-ray absorptiometry; functional foods; hips; humans; males; plums; prunes; tibia; ulna
Abstract:
... Several male animal studies have demonstrated bone-protective effects of dried plum; however, no human male study has evaluated the effect of dried plum on bone health. We conducted a randomized controlled clinical study to test if daily inclusion of 100 g of dried plum in the diet positively influenced bone mineral density (BMD), bone strength, and bone biomarkers in men. Sixty-six men were rando ...
DOI:
10.1089/jmf.2021.0080