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- Krishna Kumar Haridhasapavalan; Manash P. Borgohain; Chandrima Dey; Bitan Saha; Gloria Narayan; Sachin Kumar; Rajkumar P. Thummer
- Gene 2019 v.686 pp. 146-159
- induced pluripotent stem cells; risk; Murine respirovirus; medicine; humans; drug evaluation; ethics; somatic cells; plasmids; therapeutics; transfection; embryonic stem cells; genetic engineering; genomics; fibroblasts; Adenoviridae; transposons
- ... Over a decade ago, a landmark study that reported derivation of induced Pluripotent Stem Cells (iPSCs) by reprogramming fibroblasts has transformed stem cell research attracting the interest of the scientific community worldwide. These cells circumvent the ethical and immunological concerns associated with embryonic stem cells, and the limited self-renewal ability and restricted differentiation po ...
- Deng Wenwen; Cao Xia; Chen Jingjing; Zhang Zhijian; Yu Qingtong; Wang Yan; Shao Genbao; Zhou Jie; Gao Xiangdong; Yu Jiangnan; Xu Ximing
- ACS Applied Materials & Interfaces 2015 v.7 no.34 pp. 18957-18966
- Pleurotus eryngii; genetic engineering; humans; induced pluripotent stem cells; medicine; microRNA; nanoparticles; particle size; physicochemical properties; plasmids; polysaccharides; transcription factors; umbilical cord
- ... Induced pluripotent stem cells (iPSCs), resulting from the forced expression of cocktails out of transcription factors, such as Oct4, Sox2, Klf4, and c-Myc (OSKM), has shown tremendous potential in regenerative medicine. Although rapid progress has been made recently in the generation of iPSCs, the safety and efficiency remain key issues for further application. In this work, microRNA 302-367 was ...