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1. Formulation of Glycyrrhizic Acid-based Nanocomplexes for Enhanced Anti-cancer and Anti-inflammatory Effects of Curcumin

Author:
Jihyeon Song; Jun Yeong Kim; Gayeon You; Yoon Young Kang; Jiwon Yang; Hyejung Mok
Source:
Biotechnology and bioprocess engineering 2022 v.27 no.2 pp. 163-170
ISSN:
1226-8372
Subject:
Glycyrrhiza glabra; aqueous solutions; bioprocessing; biotechnology; blood serum; breast neoplasms; curcumin; glycyrrhizin; humans; hydrophobicity; licorice; macrophages; models; necrosis; rheumatoid arthritis; solubility; sonication; splenomegaly; Michigan
Abstract:
... In this study, nanocomplexes composed of glycyrrhizic acid (GA) derived from the root of the licorice plant (Glycyrrhiza glabra) were formulated for the delivery of curcumin (CUR). Sonication of amphiphilic GA solution with hydrophobic CUR resulted in the production of nanosized complexes with a size of 164.8 ± 51.7 nm, which greatly enhanced the solubility of CUR in aqueous solution. A majority o ...
DOI:
10.1007/s12257-021-0198-7

2. Metabolomics analysis highlights Yashtimadhu (Glycyrrhiza glabra L.)‐mediated neuroprotection in a rotenone‐induced cellular model of Parkinson's disease by restoring the mTORC1‐AMPK1 axis in autophagic regulation

Author:
Gayathree Karthikkeyan; Santosh Kumar Behera; Shubham Sukerndeo Upadhyay; Ravishankar Pervaje; Thottethodi Subrahmanya Keshava Prasad; Prashant Kumar Modi
Source:
Phytotherapy research 2022 v.36 no.5 pp. 2207-2222
ISSN:
0951-418X
Subject:
Glycyrrhiza glabra; Parkinson disease; autophagy; energy; licorice; mass spectrometry; metabolism; metabolites; metabolomics; models; neuroprotective effect; phytotherapy; research; rotenone; succinic acid; traditional medicine; tricarboxylic acid cycle
Abstract:
... Parkinson's disease (PD) is an age‐associated progressive neurodegenerative movement disorder, and its management strategies are known to cause complications with prolonged usage. We aimed to explore the neuroprotective mechanism of the Indian traditional medicine Yashtimadhu, prepared from the dried roots of Glycyrrhiza glabra L. (licorice) in the rotenone‐induced cellular model of PD. Retinoic a ...
DOI:
10.1002/ptr.7449

3. Molecular and structural insights of β-boswellic acid and glycyrrhizic acid as potent SARS-CoV-2 Envelope protein inhibitors

Author:
Syeda Warisul Fatima; Shahenvaz Alam; Sunil K. Khare
Source:
Phytomedicine plus 2022 v.2 no.2 pp. 100241
ISSN:
2667-0313
Subject:
Boswellia; Glycyrrhiza; Internet; Severe acute respiratory syndrome coronavirus 2; antiviral properties; computer software; drug design; fluorescence; glycyrrhizin; licorice; ligands; models; therapeutics; toxicity testing; triterpenoids; viruses
Abstract:
... Over million people have been infected with SARS-CoV-2 virus worldwide, with around 3% reported deaths till date. A few conventional antiviral treatments have been tried to mitigate the coronavirus. However, many alternative therapeutics are being evaluated worldwide. In the present study, we investigated traditional Indian medicinal compounds antiviral potencies as an effective drug for targeting ...
DOI:
10.1016/j.phyplu.2022.100241

4. Preclinical studies of licorice in ulcerative colitis: A systematic review with meta-analysis and network pharmacology

Author:
Peng-De Lu; Meng-Chen Yuan; Xing-Ping Quan; Jin-Fen Chen; Yong-Hua Zhao
Source:
Journal of ethnopharmacology 2022 v.296 pp. 115444
ISSN:
0378-8741
Subject:
Oriental traditional medicine; antitussive agents; clinical trials; histology; homeostasis; immunomodulators; inflammation; licorice; meta-analysis; microorganisms; models; pain; pharmacology; risk; sample size; spleen; systematic review; therapeutics; ulcerative colitis
Abstract:
... Licorice, as a traditional Chinese herbal medicine, possessing the efficacies of invigorating spleen and replenishing qi, heat-clearing and detoxicating, phlegm-resolving and cough suppressant, relieving spasm and pain, and hamonizing actions of various medicines. The goal of this systematic review, which includes meta-analysis and network pharmacology in preclinical studies, is to investigate the ...
DOI:
10.1016/j.jep.2022.115444

5. Preparation, characterization, pharmacokinetics, and antirenal injury activity studies of Licochalcone A‐loaded liposomes

Author:
Jing Liu; Zhongan Zhu; Yuhang Yang; Michael Adu‐Frimpong; Lin Chen; Hao Ji; Elmurat Toreniyazov; Qilong Wang; Jiangnan Yu; Ximing Xu
Source:
Journal of food biochemistry 2022 v.46 no.1 pp. e14007
ISSN:
0145-8884
Subject:
Oriental traditional medicine; adenine; antioxidant activity; bioavailability; encapsulation; flavonoids; functional foods; intragastric administration; licorice; models; particle size; pharmacodynamics; pharmacokinetics; renal failure; therapeutics; tissue distribution; water solubility; zeta potential
Abstract:
... A liposome of Licochalcone A (LCA‐Liposomes) was purposively prepared to ameliorate the low in vivo availability and efficacy of LCA. Physical characterization of LCA‐Liposomes was carried out mainly by determining particle size, morphology, zeta potential (Z‐potential), and efficiency of LCA encapsulation (EE) via appropriate techniques. Also, the rate of LCA release in vitro and distribution in ...
DOI:
10.1111/jfbc.14007

6. Quality assessment of fried licorice based on fingerprints and chemometrics

Author:
Xiaoyu Fan; Tingting Hong; Qilin Yang; Dilei Wang; Jing Peng; Wuqing Xiao; Xueying Yang; Xiaohong Hu; Chongli Yu; Shouying Du; Jie Bai
Source:
Food chemistry 2022 v.378 pp. 132121
ISSN:
0308-8146
Subject:
chemometrics; discriminant analysis; food chemistry; licorice; mass spectrometry; medicine; models; prediction; traceability; China
Abstract:
... Fried licorice is obtained by frying licorice without using any auxiliary materials, and it is widely used both as food and medicine in China. To explore the influence of licorice origin on the quality of fried licorice, a method based on fingerprinting and chemometrics was developed. Twenty batches of licorice were selected from four locations. The reference chromatograms of each location were es ...
DOI:
10.1016/j.foodchem.2022.132121

7. The effects of plastic film mulching and straw mulching on licorice root yield and soil organic carbon content in a dryland farming

Author:
Jianjun Yang; Rongzhu Qin; Xiaopeng Shi; Huihui Wei; Guojun Sun; Feng-Min Li; Feng Zhang
Source:
Science of the total environment 2022 v.826 pp. 154113
ISSN:
0048-9697
Subject:
Glycyrrhiza uralensis; arid lands; carbon sequestration; corn straw; environment; field experimentation; glycyrrhizin; licorice; microbial carbon; models; plastic film; plastic film mulches; soil organic carbon
Abstract:
... The increasing worldwide demand for traditional herbs has been met by growing cultivated herbs. It is undoubtedly very important to seek a reasonable cultivation mode for the yield, quality and long-term production stability of traditional herbs. In this study, licorice (Glycyrrhiza uralensis Fisch.) was investigated using a field experiment and a process-based model (Denitrification-Decomposition ...
DOI:
10.1016/j.scitotenv.2022.154113

8. Mechanisms of traditional Chinese medicines in the treatment of allergic rhinitis using a network biology approach

Author:
Li Du; Xiaotong Ye; Manman Li; Huihui Wang; Baixia Zhang; Rao Zheng; Yun Wang
Source:
Journal of traditional Chinese medical sciences 2021 v.8 no.1 pp. 82-89
ISSN:
2095-7548
Subject:
CD4-positive T-lymphocytes; Cicadidae; Cynanchum; allergic rhinitis; anti-allergic agents; antigens; bioinformatics; cell membranes; cell proliferation; databases; drug development; flowers; fruits; histamine; immunoglobulin E; interleukin-13; interleukin-4; licorice; models
Abstract:
... To systematically explore the effect and mechanism of traditional Chinese herbs in the treatment of allergic rhinitis.Magnolia flower, xanthium fruit, astragalus root, paniculate cynanchum, scutellaria root, cicada molting, stephania root, small centipeda herb, and licorice root as traditional Chinese herbs are widely used to treat allergic rhinitis. With multiple database integration and entity g ...
DOI:
10.1016/j.jtcms.2016.11.007

9. Nasal irrigation with Glycyrrhiza glabra extract for treatment of allergic rhinitis – A study of in vitro, in vivo and clinical trial

Author:
Geng-He Chang; Yu-Shih Lin; Ke-Hsin Hsu; Yu-Ching Cheng; Pei-Rung Yang; Ming-Shao Tsai; Yao-Te Tsai; Cheng-Ming Hsu; Pey-Jium Chang; Chung-Sheng Shi; Yao-Hsu Yang; Ching-Yuan Wu
Source:
Journal of ethnopharmacology 2021 v.275 pp. 114116
ISSN:
0378-8741
Subject:
Glycyrrhiza glabra; Oriental traditional medicine; acoustics; adrenal cortex hormones; allergic rhinitis; anaphylaxis; anti-allergic agents; anti-inflammatory activity; calcium; clinical trials; hypertrophy; irrigation; licorice; mast cells; models; nose; pruritus; rhinoscopy; smell; sweetness
Abstract:
... Glycyrrhiza glabra, a family of licorice and a traditional Chinese medicine with sweet taste and favorable smell, has anti-inflammatory, anti-allergic and immunomodulatory functions.Aim of the study: We developed a licorice extract (LE) by using glycyrrhiza glabra and administered it through nasal irrigation to treat allergic rhinitis (AR).LE was prepared into extract powder, and the anti-inflamma ...
DOI:
10.1016/j.jep.2021.114116

10. Predictive quality control for compound liquorice tablets by the intelligent mergence fingerprint method combined with the systematic quantitative fingerprint method

Author:
Zhifei Hou; Guoxiang Sun
Source:
Phytochemical analysis 2021 v.32 no.6 pp. 1118-1130
ISSN:
0958-0344
Subject:
anise; camphor; licorice; models; oils; phytochemicals; prediction; quality control; sodium benzoate; China
Abstract:
... INTRODUCTION: Compound liquorice tablet (CLT) is a herbal compound preparation and is used as a classic antitussive and expectorant in China. It is composed of liquorice extract powder, opioid powder, star anise oil, camphor, and sodium benzoate. The complexity of herbal materials brings a huge challenge in producing compound preparations with stable and uniform quality consistency. OBJECTIVE: To ...
DOI:
10.1002/pca.3053

11. Prevention of MEK-ERK-1/2 hyper-activation underlines the neuroprotective effect of Glycyrrhiza glabra L. (Yashtimadhu) against rotenone-induced cellular and molecular aberrations

Author:
Gayathree Karthikkeyan; Ravishankar Pervaje; Sameera Krishna Pervaje; Thottethodi Subrahmanya Keshava Prasad; Prashant Kumar Modi
Source:
Journal of ethnopharmacology 2021 v.274 pp. 114025
ISSN:
0378-8741
Subject:
Glycyrrhiza glabra; Parkinson disease; apoptosis; brain; cell cycle; cytochrome c; cytotoxicity; licorice; memory; mitochondria; models; neuroprotective effect; oxidative stress; pro-apoptotic proteins; rotenone; therapeutics; traditional medicine
Abstract:
... Yashtimadhu choorna (powder) is prepared from the dried root of Glycyrrhiza glabra L., commonly known as licorice. The Indian Ayurvedic system classifies Yashtimadhu as a Medhya Rasayana that can enhance brain function, improves memory, and possess neuroprotective functions, which can be used against neurodegenerative diseases like Parkinson's disease (PD). We aimed to decipher the neuroprotective ...
DOI:
10.1016/j.jep.2021.114025

12. Regulation of root secondary metabolites by partial root‐associated microbiotas under the shaping of licorice ecotypic differentiation in northwest China

Author:
Yang Liu; Hao Wang; Ziheng Peng; Da Li; Weimin Chen; Shuo Jiao; Gehong Wei
Source:
Journal of integrative plant biology 2021 v.63 no.12 pp. 2093-2109
ISSN:
1672-9072
Subject:
ecotypes; equations; genotyping by sequencing; geography; licorice; models; nitrogen; plant biology; plant communities; rhizosphere; secondary metabolites; soil; China
Abstract:
... Interactions between plant hosts and their microbiotas are becoming increasingly evident, while the effects of plant communities on microbial communities in different geographic environments are poorly understood. Here, the differentiation of licorice plant ecotypes and the distribution of root‐associated microbiotas were investigated across five sampling sites in northwest China. The interactions ...
DOI:
10.1111/jipb.13179

13. Succession of endophytic fungi and arbuscular mycorrhizal fungi associated with the growth of plant and their correlation with secondary metabolites in the roots of plants

Author:
Hanli Dang; Tao Zhang; Zhongke Wang; Guifang Li; Wenqin Zhao; Xinhua Lv; Li Zhuang
Source:
BMC plant biology 2021 v.21 no.1 pp. 165
ISSN:
1471-2229
Subject:
Basidiomycota; Cladosporium; Diversispora; Fusarium; Glomus; Sarocladium; endophytes; flavonoids; glycyrrhizin; high performance liquid chromatography; licorice; models; plant growth; secondary metabolites; soil; vesicular arbuscular mycorrhizae; water content
Abstract:
... BACKGROUND: To decipher the root and microbial interaction, secondary metabolite accumulation in roots and the microbial community’s succession model during the plant’s growth period demands an in-depth investigation. However, till now, no comprehensive study is available on the succession of endophytic fungi and arbuscular mycorrhizal fungi (AMF) with roots of medicinal licorice plants and the ef ...
DOI:
10.1186/s12870-021-02942-6

14. Application of an in vitro digestion model to study the metabolic profile changes of an herbal extract combination by UHPLC–HRMS

Author:
Timo A. Thumann; Eva-Maria Pferschy-Wenzig; Heba Aziz-Kalbhenn; Ramy M. Ammar; Sabine Rabini; Christine Moissl-Eichinger; Rudolf Bauer
Source:
Phytomedicine 2020 v.71 pp. 153221
ISSN:
0944-7113
Subject:
Angelica archangelica; Melissa officinalis; Mentha piperita nothosubsp. piperita; Silybum marianum; bioavailability; caffeic acid; caraway; chamomile; colon; digestion; fruits; in vitro digestion; in vitro studies; indigestion; intestinal microorganisms; isomerization; licorice; medicinal plants; metabolites; models; protein binding; roots
Abstract:
... STW 5 is a fixed herbal combination containing extracts from nine medicinal plants: bitter candytuft, greater celandine, garden angelica roots, lemon balm leaves, peppermint leaves, caraway fruits, licorice roots, chamomile flowers, and milk thistle fruit. STW 5 is a clinically proven treatment for functional dyspepsia and irritable bowel syndrome.Using a static in vitro method, we simulated oral, ...
DOI:
10.1016/j.phymed.2020.153221

15. Biological Activity and Pharmacokinetic Behavior of Fenbendazole Integrated into a Supramolecular Delivery System with Licorice Extract and Sodium Dioctyl Sulfosuccinate

Author:
A. I. Varlamova; S. O. Movsesyan; I. A. Arkhipov; S. S. Khalikov; M. V. Arisov; P. P. Kochetkov; V. E. Abramov; M. M. Il’in; B. V. Lokshin
Source:
Biology bulletin of the Russian Academy of Sciences 2020 v.47 no.6 pp. 549-558
ISSN:
1062-3590
Subject:
Trichinella spiralis; absorption; active ingredients; bioactive properties; blood; blood flow; fenbendazole; licorice; mechanochemistry; metabolites; models; oral administration; particle size; pharmacokinetics; sheep; sodium; solubility
Abstract:
... A supramolecular complex (SFBZ) of fenbendazole (FBZ) with licorice extract and sodium dioctyl sulfosuccinate is prepared by mechanochemical method, and its anthelminthic activity and metabolism in sheep are studied. Physicochemical studies of SFBZ confirmed its improved solubility and a decrease in the particle size. FBZ and its metabolites are found to display enhanced absorption into the bloods ...
DOI:
10.1134/S1062359020060138

16. Dietary compound glycyrrhetinic acid suppresses tumor angiogenesis and growth by modulating antiangiogenic and proapoptotic pathways in vitro and in vivo

Author:
Jingjing Li; Fan Tang; Renkai Li; Zhejie Chen; Simon Ming-Yuen Lee; Chaomei Fu; Jinming Zhang; George Pak-Heng Leung
Source:
Journal of nutritional biochemistry 2020 v.77 pp. 108268
ISSN:
0955-2863
Subject:
Danio rerio; angiogenesis; animal ovaries; antineoplastic activity; apoptosis; bioactive compounds; blood vessels; caspase-3; caspase-9; cell cycle checkpoints; cyclins; ex vivo studies; glycyrrhetinic acid; human umbilical vein endothelial cells; in vitro studies; in vivo studies; interphase; licorice; mechanism of action; membrane potential; mice; mitochondrial membrane; mitogen-activated protein kinase; models; neoplasm cells; ovarian neoplasms; phosphorylation; pro-apoptotic proteins; rats; receptors; signal transduction; vascular endothelial growth factor receptor-2
Abstract:
... Glycyrrhetinic acid (GA) is a major bioactive compound of licorice. The objective of this study was to investigate the effects of GA on ovarian cancer, particularly those related to angiogenesis and apoptosis, and to elucidate the underlying mechanisms of action. In vitro studies showed that GA significantly inhibited proliferation, migration, invasion and tube formation in human umbilical vein en ...
DOI:
10.1016/j.jnutbio.2019.108268

17. Evaluation of nickel stabilization in a calcareous soil amended with biochars using mathematical adsorption models

Author:
Hamid Reza Boostani; Mahdi Najafi-Ghiri; Ailsa G. Hardie
Source:
Communications in soil science and plant analysis 2020 v.51 no.9 pp. 1213-1226
ISSN:
1532-2416
Subject:
adsorption; biochar; calcareous soils; corn straw; endothermy; licorice; models; nickel; phosphorus; plant analysis; pulp; rice hulls; sorption isotherms; thermodynamics; wheat straw
Abstract:
... Batch adsorption experiments were performed to investigate the effect of different biochars (corn straw biochar (S-CSB), wheat straw biochar (S-WSB), rice husk biochar (S-RHB) and licorice root pulp biochar (S-LRB) each at 3% w/w) application on the kinetics, isotherms and thermodynamic parameters of nickel (Ni) adsorption onto a calcareous soil. The kinetics of Ni adsorption as a function of time ...
DOI:
10.1080/00103624.2020.1763382

18. Glycyrrhizin Improves Fatty Liver Symptoms, Increases Adiponectin and Reduces UCP2 Expression in Wistar Rats

Author:
Hamedeh Bagheri; Parichehreh Yaghmaei; Mohamadhosein Modaresi; Marjan Sabbaghian; Azadeh Ebrahim-Habibi
Source:
Proceedings of the National Academy of Sciences, India, Section B: biological sciences 2020 v.90 no.1 pp. 191-197
ISSN:
0369-8211
Subject:
adiponectin; bioactive compounds; body weight; catalase; fatty liver; gene expression; glucose; glycyrrhizin; high fat diet; histology; insulin; licorice; lipid composition; liver; liver cirrhosis; males; metabolic syndrome; models; rats; superoxide dismutase; India
Abstract:
... Glycyrrhizin (GL) is the main bioactive component in the extract of licorice root, with beneficial effects on metabolic syndrome. This study investigates the effect of GL on biochemical and histological parameters and UCP2 gene expression in a rodent nonalcoholic steatosis model. Thirty-two male Wistar rats were classified into four groups randomly: control (normal diet with standard rat chow), hi ...
DOI:
10.1007/s40011-019-01097-7

19. Glycyrrhizin inhibits osteoarthritis development through suppressing the PI3K/AKT/NF-κB signaling pathway in vivo and in vitro

Author:
Ren-Hao Jiang; Jia-Jing Xu; Ding-Chao Zhu; Jia-Feng Li; Chen-Xi Zhang; Nan Lin; Wei-Yang Gao
Source:
Food & function 2020 v.11 no.3 pp. 2126-2136
ISSN:
2042-650X
Subject:
anti-inflammatory activity; antioxidant activity; cartilage; chondrocytes; collagen; elderly; glycyrrhizin; humans; inducible nitric oxide synthase; interleukin-6; licorice; metalloproteinases; mice; models; nitric oxide; osteoarthritis; phosphatidylinositol 3-kinase; phosphorylation; prostaglandin synthase; prostaglandins; signal transduction; therapeutics; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:
... Osteoarthritis (OA) is a serious and frequently occurring disease in the elderly, characterized by cartilage degeneration and proliferation of bone structure. Glycyrrhizin, a compound extracted from licorice, has been reported to have various important biological activities, such as antioxidant properties and anti-inflammatory action. However, it has not been reported whether glycyrrhizin has a po ...
DOI:
10.1039/c9fo02241d

20. Licochalcone A reverses NNK-induced ectopic miRNA expression to elicit in vitro and in vivo chemopreventive effects

Author:
Bingxin Li; Di Zhou; Shuang Li; Yuan Feng; Xingyu Li; Wenhui Chang; Juan Zhang; Yu Sun; Degang Qing; Gang Chen; Ning Li
Source:
Phytomedicine 2020 v.76 pp. 153245
ISSN:
0944-7113
Subject:
apoptosis; biomarkers; cell cycle; chemoprevention; cost effectiveness; intraperitoneal injection; lung neoplasms; microRNA; models; pathogenesis
Abstract:
... Chemoprevention is the best cost-effective way regarding cancers. MicroRNAs (miRNAs) have been reported to be differentially expressed during the development of lung cancer. However, if lung cancer prevention can be achieved through modulating miRNAs expression so far remains unknown.To discover ectopically expressed miRNAs in NNK-induced lung cancer and clarify whether Licochalcone A (lico A) can ...
DOI:
10.1016/j.phymed.2020.153245

21. Licoricidin improves neurological dysfunction after traumatic brain injury in mice via regulating FoxO3/Wnt/β-catenin pathway

Author:
Cai Liu; Dongqiang He; Qiming Zhao
Source:
Natural medicines 2020 v.74 no.4 pp. 767-776
ISSN:
1340-3443
Subject:
Western blotting; antioxidant activity; apoptosis; brain; brain damage; catalase; death; drugs; edema; fluorescent antibody technique; glutathione peroxidase; licorice; males; malondialdehyde; models; neuroprotective effect; nucleotidyltransferases; phosphorylation; superoxide dismutase; therapeutics
Abstract:
... Traumatic brain injury (TBI) is a major cause of death and disability around the world with no effective treatments currently. The present study was aimed to investigate the neuroprotective effect of licoricidin, one of the major components of licorice extract, on TBI mice and further explore the underlying mechanism. Male C57BL/6 mice were modeled by a modified weight-drop method to mimic TBI. Al ...
DOI:
10.1007/s11418-020-01434-5

22. Potential role of mTORC1 and the PI3K-Akt pathway in anti-acne properties of licorice flavonoids

Author:
ShiFa Ruan; ShiJian Xiang; WenFeng Wu; SiWei Cao; QunQun Du; ZhuXian Wang; TingTing Chen; Qun Shen; Li Liu; HuoJi Chen; LiDong Weng; HongXia Zhu; Qiang Liu
Source:
Journal of functional foods 2020 v.70 pp. 103968
ISSN:
1756-4646
Subject:
Western blotting; acne; bioinformatics; flavonoids; focal adhesions; gene expression regulation; leukocytes; licorice; microfilaments; mitochondria; models; protein synthesis; proteomics; quantitative polymerase chain reaction; rats; reverse transcriptase polymerase chain reaction; signal transduction; tight junctions
Abstract:
... We applied a label-free proteomic method to explore the mechanisms of Licorice flavonoid anti-acne effects in rat. Acne model was established in the back of rats as model group (MDL), then treated with licorice flavonoid (LCF), while none treated rats as control groups (CTR). In MDL, 314 differentially expressed proteins (DEPs) and 27 significantly differentially expressed proteins (SDEPs) were id ...
DOI:
10.1016/j.jff.2020.103968

23. Prenylated Phenolic Compounds from the Aerial Parts of Glycyrrhiza uralensis as PTP1B and α-Glucosidase Inhibitors

Author:
Jing-ran Fan; Yi Kuang; Ze-yuan Dong; Yang Yi; Yan-xia Zhou; Bin Li; Xue Qiao; Min Ye
Source:
Journal of natural products 2020 v.83 no.4 pp. 814-824
ISSN:
1520-6025
Subject:
Glycyrrhiza uralensis; aerial parts; alpha-glucosidase; blood glucose; blood serum; enzyme inhibitors; ethanol; glucose; glycemic effect; herbal medicines; human cell lines; inhibitory concentration 50; insulin; insulin resistance; isoflavans; licorice; medicinal plants; mice; models; nuclear magnetic resonance spectroscopy; phenolic compounds; rhizomes; roots; spectral analysis
Abstract:
... Glycyrrhiza uralensis (liquorice) is a well-known medicinal plant. Its roots and rhizomes are used as the popular Chinese herbal medicine Gan-Cao. An ethanol extract of the aerial parts of G. uralensis showed antidiabetic effects on db/db mice. It decreased the blood glucose level by 30.3% and increased the serum insulin level by 41.8% compared to the control group. Eighty-six phenolic compounds ( ...
DOI:
10.1021/acs.jnatprod.9b00262

24. Spectrum-Effect Relationships of Flavonoids in Glycyrrhiza uralensis Fisch.

Author:
Tingting Li; Shiyao Hua; Jiahua Ma; Lin Dong; Fang Xu; Xueyan Fu
Source:
Journal of Analytical Methods in Chemistry (Online) 2020 v.2020 pp. -
ISSN:
2090-8873
Subject:
Glycyrrhiza uralensis; Oriental traditional medicine; active ingredients; alcohols; cough; extraction; flavonoids; heat; high performance liquid chromatography; least squares; licorice; mass spectrometry; medicinal properties; models; modernization; polyamides; polysaccharides; research; roots; saponins; separation; water; China
Abstract:
... Glycyrrhiza uralensis Fisch. is used in large quantities in traditional Chinese medicine. It contains flavonoids, saponins, and polysaccharides, with flavonoids being the main active ingredients. In this study, flavonoids were isolated from the roots of Glycyrrhiza uralensis Fisch. grown in 21 areas in China by water extraction, alcohol precipitation, polyamide resin separation, and other methods. ...
DOI:
10.1155/2020/8838290

25. Synthesis of triterpenoid derivatives and their anti-tumor and anti-hepatic fibrosis activities

Author:
Jing Xu; Xude Wang; Hongyu Zhang; Jiayin Yue; Yuanyuan Sun; Xiaoshu Zhang; Yuqing Zhao
Source:
Natural product research 2020 v.34 no.6 pp. 766-772
ISSN:
1478-6427
Subject:
Western blotting; acorns; antineoplastic activity; antineoplastic agents; betulinic acid; cancer therapy; esterification; fibrosis; glycyrrhetinic acid; human cell lines; industrial wastes; inhibitory concentration 50; licorice; models; neoplasm cells; neoplasms; ursolic acid; viability
Abstract:
... Oleanolic acid (1), ursolic acid (2), hederagenin (3), betulinol (4), betulinic acid (5), and glycyrrhetinic acid (6) are obtained from acorn/licorice industrial wastes with common triterpenoid structure as a model set for esterification. Eight 3,4,5-methoxybenzoyl triterpenoid derivatives (1a–6a), including four new derivatives (1a, 3a–1, 3a–2, and 3a–3), are synthesized by classical procedures. ...
DOI:
10.1080/14786419.2018.1499642

26. Potential detoxification effect of active ingredients in liquorice by upregulating efflux transporter

Author:
Yufei He; Xiaoyan Ci; Ying Xie; Xiulin Yi; Yong Zeng; Yazhuo Li; Changxiao Liu
Source:
Phytomedicine 2019 v.56 pp. 175-182
ISSN:
0944-7113
Subject:
P-glycoproteins; Western blotting; absorption; active ingredients; analgesics; flavonoids; flow cytometry; fluorescence; gene expression; herbal medicines; human cell lines; intestines; licorice; medicinal properties; messenger RNA; models; protein synthesis; reverse transcriptase polymerase chain reaction; rhodamines; saponins; triterpenoids; xenobiotics
Abstract:
... As one of most widely used herbal medicine, liquorice exhibits diverse pharmacological activities, for instance, analgesic, antitussive, antiarrhythmic, anti-inflammatory, and immune regulation. Additionally, detoxification effects were observed in combination of liquorice with other herbal drugs. The mechanism of detoxification of liquorice has been extensively investigated through material basis ...
DOI:
10.1016/j.phymed.2018.10.033

27. Quantitative fingerprint and quality control analysis of Compound Liquorice Tablet combined with antioxidant activities and chemometrics methods

Author:
Yujing Zhang; Fangliang Yang; Jing Zhang; Guoxiang Sun; Chao Wang; Yong Guo; Ran Wen; Wanyang Sun
Source:
Phytomedicine 2019 v.59 pp. 152790
ISSN:
0944-7113
Subject:
active ingredients; alkaloids; antioxidant activity; antioxidants; bioactive compounds; chemometrics; cluster analysis; flavonoids; herbal medicines; high performance liquid chromatography; least squares; licorice; medicinal properties; models; monitoring; quality control; saponins
Abstract:
... Herbal medicine (HM), as a complex system, is difficult to investigate their quality consistency effectively by chromatographic fingerprinting obtained in a single detection method. Moreover, active compound discovery affords no information about pharmacological activity until late in the discovery process, and the interaction between HMs in vitro is not yet clear, which requires sufficient practi ...
DOI:
10.1016/j.phymed.2018.12.013

28. Variation in the phytochemical contents and antioxidant activity of Glycyrrhiza glabra populations collected in Iran

Author:
Hassan Esmaeili; Akbar Karami; Javad Hadian; Mohammad Jamal Saharkhiz; Samad Nejad Ebrahimi
Source:
Industrial crops and products 2019 v.137 pp. 248-259
ISSN:
0926-6690
Subject:
Glycyrrhiza glabra; aerial parts; altitude; antioxidant activity; atmospheric precipitation; cork; food industry; geographic information systems; glycyrrhizin; habitats; inhibitory concentration 50; licorice; medicinal plants; models; pharmaceutical industry; phytochemicals; temperature; texture; Iran
Abstract:
... Glycyrrhiza glabra (Fabaceae) is a perennial herb including valuable and commercial constituents such as glycyrrhizic acid and glabridin which has attracted the attention of food and pharmaceutical industries. In the present study, a variation on the phytochemical and antioxidant activity of 22 populations of valuable and profitable medicinal plant Glycyrrhiza glabra (licorice) was investigated. W ...
DOI:
10.1016/j.indcrop.2019.05.034

29. A targeted strategy to identify untargeted metabolites from in vitro to in vivo: Rapid and sensitive metabolites profiling of licorice in rats using ultra-high performance liquid chromatography coupled with triple quadrupole-linear ion trap mass spectrometry

Author:
Meilin Huang; Zhongzhe Cheng; Lu Wang; Yulin Feng; Jiangeng Huang; Zhifeng Du; Hongliang Jiang
Source:
Journal of chromatography 2018 v.1092 pp. 40-50
ISSN:
1570-0232
Subject:
Oriental traditional medicine; biochemical pathways; feces; high performance liquid chromatography; licorice; liver microsomes; mass spectrometry; metabolic studies; metabolism; metabolites; models; oral administration; rats; ultra-performance liquid chromatography; urine
Abstract:
... It is challenging to conduct in vivo metabolic study for traditional Chinese medicines (TCMs) because of complex components, unpredictable metabolic pathways and low metabolite concentrations. Herein, we proposed a sensitive strategy to characterize TCM metabolites in vivo at an orally clinical dose using ultra-high performance liquid chromatography-triple quadrupole-linear ion trap mass spectrome ...
DOI:
10.1016/j.jchromb.2018.05.044

30. Licochalcone A attenuates glioma cell growth in vitro and in vivo through cell cycle arrest

Author:
Wan Jung LuThese authors contributed equally to this manuscript.; Gong Jhe Wu; Ray Jade Chen; Chao Chien Chang; Li Ming Lien; Ching Chuan Chiu; Mei Fang Tseng; Li Ting Huang; Kuan Hung Lin
Source:
Food & function 2018 v.9 no.8 pp. 4500-4507
ISSN:
2042-650X
Subject:
active ingredients; anti-inflammatory activity; antineoplastic activity; brain; cell cycle checkpoints; cell growth; cyclin-dependent kinase; cyclins; glioblastoma; licorice; messenger RNA; models; neoplasm cells; protein content
Abstract:
... Licochalcone A (LA), an active ingredient of licorice, has multiple biological activities, including antioxidative and anti-inflammatory activities. Although LA exerts antitumor effects in various cancer cells, its role in gliomas remains unclear. Therefore, this study determined whether LA inhibits glioma cell growth in vitro and in vivo. The present data revealed that LA effectively inhibited th ...
DOI:
10.1039/c8fo00728d

31. The therapeutic effect of Yinhuangerchen mixture on Avian infectious laryngotracheitis

Author:
Tie Zhang; Jian Chen; Chunguang Wang; Wanyu Shi; Dinggang Li
Source:
Poultry science 2018 v.97 no.8 pp. 2690-2697
ISSN:
0032-5791
Subject:
Gallid alphaherpesvirus 1; Scutellaria baicalensis; chickens; herbal medicines; licorice; medicinal properties; models; mucosal immunity; necropsy; therapeutics; thin layer chromatography
Abstract:
... The study was conducted to investigate the effect of Yinhuangerchen mixture (YM) on Avian infectious laryngotracheitis (AILT) induced by artificial infection and provide a scientific basis for its clinical application. A total of 200 chickens were challenged with infectious laryngotracheitis virus (ILTV). At 72 h post-challenge, the chickens were treated with different doses of YM or the Chinese h ...
DOI:
10.3382/ps/pey125

32. Benign development of cotton with antibacterial activity and metal sorpability through introduction amino triazole moieties and AgNPs in cotton structure pre-treated with periodate

Author:
Amina L. Mohamed; Ahmed G. Hassabo; S. Shaarawy; A. Hebeish
Source:
Carbohydrate polymers 2017 v.178 pp. 251-259
ISSN:
0144-8617
Subject:
cotton; Escherichia coli; nitrogen; sorption; triazoles; models; nanosilver; silver; cellulose; particle size; sorption isotherms; cotton fabric; licorice; metal ions; aldehydes; bacteria; antibacterial properties
Abstract:
... The research work presented herein was undertaken with a view to develop, characterize and highlight modified cotton fabrics that acquire durable antibacterial activity in concomitant with high metal sorption capacity. The development is based on reacting cotton cellulose previously oxidized by sodium periodate-with 4 amino-1,2,4 triazole in presence and absence of silver nano particles (AgNPs). T ...
DOI:
10.1016/j.carbpol.2017.09.024

33. Characterization of the Key Aroma Compounds in Heat-Processed Licorice (Succus Liquiritiae) by Means of Molecular Sensory Science

Author:
Wagner Juliane; Schieberle Peter; Granvogl Michael
Source:
Journal of agricultural and food chemistry 2017 v.65 no.1 pp. 132-138
ISSN:
1520-5118
Subject:
cineole; flavor compounds; isotope dilution technique; licorice; models; odor compounds; odors; stable isotopes; sucrose; vanillin
Abstract:
... Application of the sensomics concept elucidated the key odorants of heat-processed licorice (Succus Liquiritiae). Forty-nine aroma-active compounds with flavor dilution (FD) factors between 16 and 2048 were detected; 47 thereof were identified, 23 for the first time in heated licorice. 4-Hydroxy-2,5-dimethylfuran-3(2H)-one revealed the highest FD factor of 2048, followed by 3-hydroxy-4,5-dimethylf ...
DOI:
10.1021/acs.jafc.6b04499

34. Comparative metabolomics analysis for the compatibility and incompatibility of kansui and licorice with different ratios by UHPLC-QTOF/MS and multivariate data analysis

Author:
Juan Shen; Zong-Jin Pu; Jun Kai; An Kang; Yu-Ping Tang; Li-Li Shang; Gui-Sheng Zhou; Zhen-Hua Zhu; Er-Xin Shang; Shao-Ping Li; Yu-Jie Cao; Wei-Wei Tao; Shu-Lan Su; Li Zhang; Huiping Zhou; Da-Wei Qian; Jin-Ao Duan
Source:
Journal of chromatography 2017 v.1057 pp. 40-45
ISSN:
1570-0232
Subject:
Euphorbia kansui; metabolism; nicotinamide; urine; biomarkers; models; least squares; biochemical pathways; seleno amino acids; ultra-performance liquid chromatography; toxicity; licorice; mass spectrometry; metabolomics; Oriental traditional medicine; rats
Abstract:
... Kansui, the root of Euphorbia kansui T.N. Liou ex T.P. Wang (Euphorbiaceae), is a well-known poisonous traditional Chinese medicine (TCM). However, many monographs of TCM indicated that it cannot be co-used with licorice, as kansui-licorice is a typical “eighteen incompatible” medicaments. Our previous studies have indicated that kansui was effective in treating malignant pleural effusion (MPE), a ...
DOI:
10.1016/j.jchromb.2017.04.042

35. Focusing and non-focusing modulation strategies for the improvement of on-line two-dimensional hydrophilic interaction chromatography × reversed phase profiling of complex food samples

Author:
Lidia Montero; Elena Ibáñez; Mariateresa Russo; Luca Rastrelli; Alejandro Cifuentes; Miguel Herrero
Source:
Analytica chimica acta 2017 pp. -
ISSN:
0003-2670
Subject:
analytical chemistry; comprehensive two-dimensional liquid chromatography; food analysis; hydrophilic interaction chromatography; licorice; models; solvents
Abstract:
... Comprehensive two-dimensional liquid chromatography (LC × LC) is ever gaining interest in food analysis, as often, food-related samples are too complex to be analyzed through one-dimensional approaches. The use of hydrophilic interaction chromatography (HILIC) combined with reversed phase (RP) separations has already been demonstrated as a very orthogonal combination, which allows attaining increa ...
DOI:
10.1016/j.aca.2017.07.013

36. iTRAQ-based quantitative proteomic analysis reveals Bai-Hu-Tang enhances phagocytosis and cross-presentation against LPS fever in rabbit

Author:
Shidong Zhang; Dongsheng Wang; Shuwei Dong; Zhiqiang Yang; Zuoting Yan
Source:
Journal of ethnopharmacology 2017 v.207 pp. 1-7
ISSN:
0378-8741
Subject:
Anemarrhena; actin; bioinformatics; body weight; butylated hydroxytoluene; fever; gene expression regulation; gene ontology; gypsum; licorice; lipopolysaccharides; liquid chromatography; liver; major histocompatibility complex; models; phagocytosis; phagosomes; protein content; protein synthesis; proteomics; rabbits; rhizomes; ribosomes; rice; structural proteins; tandem mass spectrometry; thirst; traditional medicine
Abstract:
... Bai-Hu-Tang (BHT), a classical anti-febrile Chinese formula comprising of liquorice, anemarrhena rhizome, gypsum and rice, has been traditionally used to anti-febrile treatment and promote the production of body fluid to relieve thirst. In this paper, we aim to explore anti-febrile mechanism of BHT at protein level through analyzing alteration of differentially expressed proteins (DEPs) both lipop ...
DOI:
10.1016/j.jep.2017.05.022

37. Characterization of the Key Aroma Compounds in Raw Licorice (Glycyrrhiza glabra L.) by Means of Molecular Sensory Science

Author:
Wagner Juliane; Granvogl Michael; Schieberle Peter
Source:
Journal of agricultural and food chemistry 2016 v.64 no.44 pp. 8388-8396
ISSN:
1520-5118
Subject:
Glycyrrhiza glabra; flavor; gas chromatography-mass spectrometry; isotope dilution technique; licorice; linalool; mixing; models; odor compounds; odors; stable isotopes; vanillin
Abstract:
... Application of the molecular sensory science concept including aroma extract dilution analysis (AEDA) on the basis of gas chromatography–olfactometry combined with gas chromatography–mass spectrometry elucidated the key odorants of raw licorice (Glycyrrhiza glabra L.). Fifty aroma-active compounds were located via AEDA; 16 thereof were identified in raw licorice for the first time. γ-Nonalactone, ...
DOI:
10.1021/acs.jafc.6b03676

38. Impacts of Imazapyr and Triclopyr Soil Residues on the Growth of Several Restoration Species

Author:
Cameron H. Douglass; Scott J. Nissen; Paul J. Meiman; Andrew R. Kniss
Source:
Rangeland ecology & management 2016 v.69 no.3 pp. 199-205
ISSN:
1550-7424
Subject:
Bouteloua curtipendula; Elymus trachycaulus; Pascopyrum smithii; Sporobolus airoides; Tamarix; anthropogenic activities; dose response; ecosystems; grasses; half life; herbicide residues; herbicide resistance; high performance liquid chromatography; highlands; imazapyr; in vitro studies; invasive species; licorice; managers; models; perennial weeds; planting; rangelands; soil properties; soil types; triclopyr; woody plants; Colorado
Abstract:
... Herbicides are frequently used in natural systems to control invasive plants, but nontarget impacts from persistent soil residues can result in unintended ecosystem effects. Imazapyr and triclopyr are herbicides that are widely used in noncrop areas such as rangelands to manage perennial weeds, especially woody species such as tamarisk (saltcedar). Due to widespread environmental and anthropogenic ...
DOI:
10.1016/j.rama.2016.01.006

39. Promoting effect of licorice extract on spermatogonial proliferation and spermatocytes differentiation of neonatal mice in vitro

Author:
Cheng Wang; Yuji Jin; Yingji Jin
Source:
In vitro cellular & developmental biology 2016 v.52 no.2 pp. 149-155
ISSN:
1071-2690
Subject:
Glycyrrhiza uralensis; antibodies; herbal medicines; immunohistochemistry; in vitro studies; licorice; male fertility; mice; models; neonates; organ culture; proliferating cell nuclear antigen; quantitative analysis; recombinant proteins; spermatocytes; spermatogenesis; spermatogonia; staining; synaptonemal complex; testes
Abstract:
... Licorice (glycyrrhiza uralensis) is known as an herb with detoxication, and it has been widely used in clinical prescription of Oriental herbal medicine. Studies on the effects of licorice in the reproductive system were very rare, especially in spermatogenesis. In order to elucidate the effects of licorice on spermatogonial proliferation and spermatocyte differentiation during neonatal mice sperm ...
DOI:
10.1007/s11626-015-9966-z

40. Subtleties of human exposure and response to chemical mixtures from spills

Author:
Katherine Phetxumphou; Andrea M. Dietrich; Narasimhamurthy Shanaiah; Elizabeth Smiley; Daniel L. Gallagher
Source:
Environmental pollution 2016 v.214 pp. 618-626
ISSN:
0269-7491
Subject:
air; breathing; chromatography; cis-trans isomers; drinking water; hazard characterization; human health; humans; ingestion; licorice; models; nuclear magnetic resonance spectroscopy; odors; temperature; volatilization; water quality
Abstract:
... Worldwide, chemical spills degrade drinking water quality and threaten human health through ingestion and inhalation. Spills are often mixtures of chemicals; thus, understanding the interaction of chemical and biological properties of the major and minor components is critical to assessing human exposure. The crude (4-methylcyclohexyl)methanol (MCHM) spill provides an opportunity to assess such su ...
DOI:
10.1016/j.envpol.2016.04.056

41. The dosage-toxicity-efficacy relationship of kansui and licorice in malignant pleural effusion rats based on factor analysis

Author:
Juan Shen; Jun Wang; Er-Xin Shang; Yu-Ping Tang; Jun Kai; Yu-Jie Cao; Gui-Sheng Zhou; Wei-Wei Tao; An Kang; Shu-Lan Su; Li Zhang; Da-Wei Qian; Jin-Ao Duan
Source:
Journal of ethnopharmacology 2016 v.186 pp. 251-256
ISSN:
0378-8741
Subject:
Euphorbia kansui; Glycyrrhiza glabra; Glycyrrhiza uralensis; Oriental traditional medicine; ascites; asthma; blood serum; edema; factor analysis; furosemide; herbal medicines; interferon-gamma; interleukin-2; licorice; models; rats; toxicity; tumor necrosis factor-alpha; urine; Asia; Southern European region
Abstract:
... The root of Euphorbia kansui T.P. Wang (Euphorbiaceae), a well-known traditional Chinese medicine (TCM) with certain toxicity, is known as Gan sui (Chinese: 甘遂) or kansui. It has been used to treat edema, ascites, asthma, and etc. Licorice is the root of Glycyrrhiza uralensis Fisch. or Glycyrrhiza inflate Bat. or Glycyrrhiza glabra L., Leguminosae. It is a widely used herbal medicine native to sou ...
DOI:
10.1016/j.jep.2016.04.012

42. Effects of herbal drugs in Mahuang decoction and their main components on intestinal transport characteristics of Ephedra alkaloids evaluated by a Caco-2 cell monolayer model

Author:
Mengkai Zheng; Huifen Zhou; Haitong Wan; Yu-Lin Chen; Yu He
Source:
Journal of ethnopharmacology 2015 v.164 pp. 22-29
ISSN:
0378-8741
Subject:
Cassia; Ephedra; Oriental traditional medicine; P-glycoproteins; absorption; alkaloids; amygdalin; apricots; branches; essential oils; glomerulonephritis; herbal medicines; human cell lines; ingredients; intestinal absorption; licorice; models; permeability; pseudoephedrine; renal failure; respiratory tract diseases; seeds; therapeutics; toxicity; verapamil
Abstract:
... Mahuang decoction, Ephedra combined with Cassia twig, Bitter apricot kernel and Prepared licorice, has been widely used as a multi-herb prescription in traditional Chinese medicine (TCM). Many modern pharmacological studies have shown that the compatibility application of these four herbs has promising therapeutic effects on respiratory infection, acute glomerulonephritis and chronic renal failure ...
DOI:
10.1016/j.jep.2015.01.043

43. Evaluation of the value of near infrared (NIR) spectromicroscopy for the analysis of glycyrrizhic acid in licorice

Author:
Zhi-Sheng WU; Lu-Wei ZHOU; Sheng-Yun DAI; Xin-Yuan SHI; Yan-Jiang QIAO
Source:
Chinese journal of natural medicines 2015 v.13 no.4 pp. 316-320
ISSN:
1875-5364
Subject:
Glycyrrhiza uralensis; Oriental traditional medicine; glycyrrhizin; least squares; licorice; medicinal plants; models; near-infrared spectroscopy; prediction
Abstract:
... It has been reported that hyperspectral data could be employed to qualitatively elucidate the spatial composition of tablets of Chinese medicinal plants. To gain more insights into this technology, a quantitative profile provided by near infrared (NIR) spectromicroscopy was further studied by determining the glycyrrhizic acid content in licorice, Glycyrrhiza uralensis. Thirty-nine samples from twe ...
DOI:
10.1016/S1875-5364(15)30022-4

44. Laminaria japonica increases plasma exposure of glycyrrhetinic acid following oral administration of Liquorice extract in rats

Author:
Wei-Man ZHAO; Shu-Wen JIANG; Yang CHEN; Ze-Yu ZHONG; Zhong-Jian WANG; Mian ZHANG; Ying LI; Ping XU; Li LIU; Xiao-Dong LIU
Source:
Chinese journal of natural medicines 2015 v.13 no.7 pp. 540-549
ISSN:
1875-5364
Subject:
Laminaria; Oriental traditional medicine; Saccharina japonica; absorption; duodenum; glycyrrhizin; intestinal absorption; jejunum; large intestine; licorice; liquid chromatography; mass spectrometry; models; oral administration; pharmacokinetics; rats
Abstract:
... The present study was designed to investigate the effects of Laminaria japonica (Laminaria) on pharmacokinetics of glycyrrhetinic acid (GA) following oral administration of Liquorice extract in rats. Following oral administrations of single-dose and multi-dose Liquorice extract and Liquorice-Laminaria extract, respectively, plasma samples were obtained at various times and the concentrations of GA ...
DOI:
10.1016/S1875-5364(15)30049-2

45. Method validation for the analysis of licorice acid in the blending process by near infrared diffuse reflectance spectroscopy

Author:
Zhong Xue; Bing Xu; Chan Yang; Xianglong Cui; Jianyu Li; Xinyuan Shi; Yanjiang Qiao
Source:
Analytical methods 2015 v.7 no.14 pp. 5830-5837
ISSN:
1759-9679
Subject:
chemometrics; guidelines; least squares; licorice; mixing; models; near-infrared spectroscopy; reflectance spectroscopy; risk; talc
Abstract:
... The present work describes the validation of the near infrared (NIR) method for the quantification of the concentration of licorice acid in the blending process of licorice and talcum powder mixtures. The NIR diffuse reflectance spectra of samples were collected during the mixing process and the partial least squares (PLS) model was developed. The accuracy profile (AP) approach that was fully comp ...
DOI:
10.1039/c5ay01289a

46. Protective Effects of Glycyrrhizic Acid and 18β-Glycyrrhetinic Acid against Cisplatin-Induced Nephrotoxicity in BALB/c Mice

Author:
Chi-Hao Wu; An-Zhi Chen; Gow-Chin Yen
Source:
Journal of agricultural and food chemistry 2015 v.63 no.4 pp. 1200-1209
ISSN:
0021-8561
Subject:
adverse effects; blood; cisplatin; creatinine; glycyrrhizin; inflammation; kidney cells; kidneys; lactate dehydrogenase; licorice; males; mice; models; necrosis; nephrotoxicity; nucleoproteins; oral administration; protective effect; transcription factor NF-kappa B; urea nitrogen
Abstract:
... The clinical use of antineoplastic drug cisplatin (CP) is commonly complicated by nephrotoxic side effects that limit its application and therapeutic efficiency. This study used a model of CP-induced renal injury in male BALB/c mice to investigate the protective effects of the active components of licorice, glycyrrhizic acid (GA), and 18β-glycyrrhetinic acid (18βGA) against CP-induced nephrotoxi ...
DOI:
10.1021/jf505471a

47. Influences of vanillin and licorice root extract supplementations on the decimal reduction times of Escherichia coli O157:H7 in mildly heated young coconut liquid endosperm

Author:
Alonzo A. Gabriel; Jennifer Karen F. Pineda
Source:
Food control 2014 v.38 pp. 136-141
ISSN:
0956-7135
Subject:
Escherichia coli O157; additives; coconuts; consumer acceptance; endosperm; heat; licorice; models; pasteurization; quality control; vanillin
Abstract:
... This study determined the influences of supplementing different combinations of vanillin (0–500 ppm) and licorice root extract (LRE, 0–420 ppm) on the mild heat (55 °C) decimal reduction times (D55-values) of a cocktail of Escherichia coli O157:H7 in young coconut liquid endosperm. The maximum level of supplementation per additive tested was previously established not to result in the lowering of ...
DOI:
10.1016/j.foodcont.2013.10.011

48. Pharmacokinetic study of liquiritin in rat serum using molecularly imprinted solid-phase extraction combined with RP-HPLC

Author:
Huang Yang; Li Kang; Shao Hui Kai; Liu Sheng Quan; Xiang Fei Jun
Source:
Analytical methods 2014 v.6 no.5 pp. 1563-1568
ISSN:
1759-9679
Subject:
acrylamides; blood serum; ethylene glycol; licorice; models; molecular imprinting; oral administration; pharmacokinetics; polymerization; polymers; rats; reversed-phase high performance liquid chromatography; solid phase extraction
Abstract:
... A method using molecularly imprinted solid-phase extraction combined with RP-HPLC-UV was developed for determination of liquiritin (LQR) in rat plasma after oral administration of Compound Liquorice Tablets (CLTs). To this end, molecularly imprinted polymers were prepared by in situ polymerization, using LQR as the template, acrylamide as the functional monomer, and ethylene glycol dimethacrylate ...
DOI:
10.1039/c3ay42084a

49. Quantitative analysis of ligand effects on bioefficacy of nanoemulsion encapsulating depigmenting active

Author:
Nicolas Atrux-Tallau; Juliette Lasselin; Sang-Hoon Han; Thomas Delmas; Jérôme Bibette
Source:
Colloids and Surfaces B: Biointerfaces 2014 v.122 pp. 390-395
ISSN:
0927-7765
Subject:
bioavailability; colloids; cosmetics; droplets; drugs; encapsulation; hyaluronic acid; licorice; ligands; melanin; melanocytes; melanogenesis; models; nanocarriers; nanoemulsions; quantitative analysis; solubilization; synergism
Abstract:
... Efficient skin delivery of active molecules is the main challenge to overcome in order to achieve significant therapeutic efficiency of cosmetics or dermo-pharmaceutical products. Nanocarriers such as nanoemulsions have been envisaged to overcome main challenges of active solubilization, protection and transport to their site of biological action. Nonetheless, their skin permeation is still limite ...
DOI:
10.1016/j.colsurfb.2014.07.021

50. Dehydroglyasperin C, a component of liquorice, attenuates proliferation and migration induced by platelet-derived growth factor in human arterial smooth muscle cells

Author:
Hyo Jung Kim; Byung-Yoon Cha; In Sil Park; Ji Sun Lim; Je-Tae Woo; Jong-Sang Kim
Source:
British journal of nutrition 2013 v.110 no.3 pp. 391-400
ISSN:
1475-2662
Subject:
DNA; active ingredients; antioxidant activity; cell movement; cyclin-dependent kinase; cyclins; cytotoxicity; dissociation; dose response; humans; interphase; licorice; long term effects; medicinal properties; microfilaments; models; myocytes; phosphorylation; phytopharmaceuticals; platelet-derived growth factor; rats; smooth muscle; thymidine; traditional medicine
Abstract:
... Liquorice is one of the botanicals used frequently as a traditional medicine in the West and in the East. Platelet-derived growth factor (PDGF)-BB is involved in the development of CVD by inducing abnormal proliferation and migration of vascular smooth muscle cells. In our preliminary study, dehydroglyasperin C (DGC), an active compound of liquorice, showed strong antioxidant activity. Since phyto ...
DOI:
10.1017/S0007114512005399
PubMed:
23298457