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1. 18β-Glycyrrhetinic acid inhibits adipogenic differentiation and stimulates lipolysis

Author:
Myung-Hee Moon; Jae-Kyo Jeong; You-Jin Lee; Jae-Won Seol; Dong-Choon Ahn; In-Shik Kim; Sang-Youel Park
Source:
Biochemical and biophysical research communications 2012 v.420 no.4 pp. 805-810
ISSN:
0006-291X
Subject:
Western blotting; adipocytes; adipogenesis; adiponectin; anti-inflammatory activity; antibacterial properties; enzymes; gene expression regulation; glycerol; insulin; licorice; lipolysis; messenger RNA; mice; models; obesity; phosphorylation; reverse transcriptase polymerase chain reaction; serine; transcription (genetics); transcription factors
Abstract:
... 18β-Glycyrrhetinic acid (18β-GA) obtained from the herb liquorice has various pharmacological properties including anti-inflammatory and anti-bacterial activities. However, potential biological anti-obesity activities are unclear. In this study, novel biological activities of 18β-GA in the adipogenesis of 3T3-L1 preadipocytes and in lipolysis of differentiated adipocytes were identified. Mouse 3T3 ...
DOI:
10.1016/j.bbrc.2012.03.078

2. A targeted strategy to identify untargeted metabolites from in vitro to in vivo: Rapid and sensitive metabolites profiling of licorice in rats using ultra-high performance liquid chromatography coupled with triple quadrupole-linear ion trap mass spectrometry

Author:
Meilin Huang; Zhongzhe Cheng; Lu Wang; Yulin Feng; Jiangeng Huang; Zhifeng Du; Hongliang Jiang
Source:
Journal of chromatography 2018 v.1092 pp. 40-50
ISSN:
1570-0232
Subject:
Oriental traditional medicine; biochemical pathways; feces; high performance liquid chromatography; licorice; liver microsomes; mass spectrometry; metabolic studies; metabolism; metabolites; models; oral administration; rats; ultra-performance liquid chromatography; urine
Abstract:
... It is challenging to conduct in vivo metabolic study for traditional Chinese medicines (TCMs) because of complex components, unpredictable metabolic pathways and low metabolite concentrations. Herein, we proposed a sensitive strategy to characterize TCM metabolites in vivo at an orally clinical dose using ultra-high performance liquid chromatography-triple quadrupole-linear ion trap mass spectrome ...
DOI:
10.1016/j.jchromb.2018.05.044

3. Analytical strategy to reveal the in vivo process of multi-component herbal medicine: A pharmacokinetic study of licorice using liquid chromatography coupled with triple quadrupole mass spectrometry

Author:
Xue Qiao; Min Ye; Cheng Xiang; Qing Wang; Chun-fang Liu; Wen-juan Miao; De-an Guo
Source:
Journal of chromatography 2012 v.1258 no. pp. 84-93
ISSN:
0021-9673
Subject:
Glycyrrhiza uralensis; bioavailability; chalcone; coumarin; glycyrrhizin; herbal medicines; isoflavones; licorice; liquid chromatography; mass spectrometry; metabolites; models; monitoring; pharmacokinetics; rats; saponins; toxicity
Abstract:
... Although various techniques have been employed to analyze drug metabolites, the metabolism of multi-component herbal medicine has seldom been fully addressed. In contrast to chemical drugs, a number of compounds in herbal medicine could get into circulation and then be metabolized. Moreover, these compounds may have metabolic interactions which make their pharmacokinetics (PK) even more complicate ...
DOI:
10.1016/j.chroma.2012.08.041

4. Application of an in vitro digestion model to study the metabolic profile changes of an herbal extract combination by UHPLC–HRMS

Author:
Timo A. Thumann; Eva-Maria Pferschy-Wenzig; Heba Aziz-Kalbhenn; Ramy M. Ammar; Sabine Rabini; Christine Moissl-Eichinger; Rudolf Bauer
Source:
Phytomedicine 2020 v.71 pp. 153221
ISSN:
0944-7113
Subject:
Angelica archangelica; Melissa officinalis; Mentha piperita nothosubsp. piperita; Silybum marianum; bioavailability; caffeic acid; caraway; chamomile; colon; digestion; fruits; in vitro digestion; in vitro studies; indigestion; intestinal microorganisms; isomerization; licorice; medicinal plants; metabolites; models; protein binding; roots
Abstract:
... STW 5 is a fixed herbal combination containing extracts from nine medicinal plants: bitter candytuft, greater celandine, garden angelica roots, lemon balm leaves, peppermint leaves, caraway fruits, licorice roots, chamomile flowers, and milk thistle fruit. STW 5 is a clinically proven treatment for functional dyspepsia and irritable bowel syndrome.Using a static in vitro method, we simulated oral, ...
DOI:
10.1016/j.phymed.2020.153221

5. Benign development of cotton with antibacterial activity and metal sorpability through introduction amino triazole moieties and AgNPs in cotton structure pre-treated with periodate

Author:
Amina L. Mohamed; Ahmed G. Hassabo; S. Shaarawy; A. Hebeish
Source:
Carbohydrate polymers 2017 v.178 pp. 251-259
ISSN:
0144-8617
Subject:
cotton; Escherichia coli; nitrogen; sorption; triazoles; models; nanosilver; silver; cellulose; particle size; sorption isotherms; cotton fabric; licorice; metal ions; aldehydes; bacteria; antibacterial properties
Abstract:
... The research work presented herein was undertaken with a view to develop, characterize and highlight modified cotton fabrics that acquire durable antibacterial activity in concomitant with high metal sorption capacity. The development is based on reacting cotton cellulose previously oxidized by sodium periodate-with 4 amino-1,2,4 triazole in presence and absence of silver nano particles (AgNPs). T ...
DOI:
10.1016/j.carbpol.2017.09.024

6. Biological Activity and Pharmacokinetic Behavior of Fenbendazole Integrated into a Supramolecular Delivery System with Licorice Extract and Sodium Dioctyl Sulfosuccinate

Author:
A. I. Varlamova; S. O. Movsesyan; I. A. Arkhipov; S. S. Khalikov; M. V. Arisov; P. P. Kochetkov; V. E. Abramov; M. M. Il’in; B. V. Lokshin
Source:
Biology bulletin of the Russian Academy of Sciences 2020 v.47 no.6 pp. 549-558
ISSN:
1062-3590
Subject:
Trichinella spiralis; absorption; active ingredients; bioactive properties; blood; blood flow; fenbendazole; licorice; mechanochemistry; metabolites; models; oral administration; particle size; pharmacokinetics; sheep; sodium; solubility
Abstract:
... A supramolecular complex (SFBZ) of fenbendazole (FBZ) with licorice extract and sodium dioctyl sulfosuccinate is prepared by mechanochemical method, and its anthelminthic activity and metabolism in sheep are studied. Physicochemical studies of SFBZ confirmed its improved solubility and a decrease in the particle size. FBZ and its metabolites are found to display enhanced absorption into the bloods ...
DOI:
10.1134/S1062359020060138

7. Characterization of the Key Aroma Compounds in Heat-Processed Licorice (Succus Liquiritiae) by Means of Molecular Sensory Science

Author:
Wagner Juliane; Schieberle Peter; Granvogl Michael
Source:
Journal of agricultural and food chemistry 2017 v.65 no.1 pp. 132-138
ISSN:
1520-5118
Subject:
cineole; flavor compounds; isotope dilution technique; licorice; models; odor compounds; odors; stable isotopes; sucrose; vanillin
Abstract:
... Application of the sensomics concept elucidated the key odorants of heat-processed licorice (Succus Liquiritiae). Forty-nine aroma-active compounds with flavor dilution (FD) factors between 16 and 2048 were detected; 47 thereof were identified, 23 for the first time in heated licorice. 4-Hydroxy-2,5-dimethylfuran-3(2H)-one revealed the highest FD factor of 2048, followed by 3-hydroxy-4,5-dimethylf ...
DOI:
10.1021/acs.jafc.6b04499

8. Characterization of the Key Aroma Compounds in Raw Licorice (Glycyrrhiza glabra L.) by Means of Molecular Sensory Science

Author:
Wagner Juliane; Granvogl Michael; Schieberle Peter
Source:
Journal of agricultural and food chemistry 2016 v.64 no.44 pp. 8388-8396
ISSN:
1520-5118
Subject:
Glycyrrhiza glabra; flavor; gas chromatography-mass spectrometry; isotope dilution technique; licorice; linalool; mixing; models; odor compounds; odors; stable isotopes; vanillin
Abstract:
... Application of the molecular sensory science concept including aroma extract dilution analysis (AEDA) on the basis of gas chromatography–olfactometry combined with gas chromatography–mass spectrometry elucidated the key odorants of raw licorice (Glycyrrhiza glabra L.). Fifty aroma-active compounds were located via AEDA; 16 thereof were identified in raw licorice for the first time. γ-Nonalactone, ...
DOI:
10.1021/acs.jafc.6b03676

9. Comparative metabolomics analysis for the compatibility and incompatibility of kansui and licorice with different ratios by UHPLC-QTOF/MS and multivariate data analysis

Author:
Juan Shen; Zong-Jin Pu; Jun Kai; An Kang; Yu-Ping Tang; Li-Li Shang; Gui-Sheng Zhou; Zhen-Hua Zhu; Er-Xin Shang; Shao-Ping Li; Yu-Jie Cao; Wei-Wei Tao; Shu-Lan Su; Li Zhang; Huiping Zhou; Da-Wei Qian; Jin-Ao Duan
Source:
Journal of chromatography 2017 v.1057 pp. 40-45
ISSN:
1570-0232
Subject:
Euphorbia kansui; metabolism; nicotinamide; urine; biomarkers; models; least squares; biochemical pathways; seleno amino acids; ultra-performance liquid chromatography; toxicity; licorice; mass spectrometry; metabolomics; Oriental traditional medicine; rats
Abstract:
... Kansui, the root of Euphorbia kansui T.N. Liou ex T.P. Wang (Euphorbiaceae), is a well-known poisonous traditional Chinese medicine (TCM). However, many monographs of TCM indicated that it cannot be co-used with licorice, as kansui-licorice is a typical “eighteen incompatible” medicaments. Our previous studies have indicated that kansui was effective in treating malignant pleural effusion (MPE), a ...
DOI:
10.1016/j.jchromb.2017.04.042

10. Dehydroglyasperin C, a component of liquorice, attenuates proliferation and migration induced by platelet-derived growth factor in human arterial smooth muscle cells

Author:
Hyo Jung Kim; Byung-Yoon Cha; In Sil Park; Ji Sun Lim; Je-Tae Woo; Jong-Sang Kim
Source:
British journal of nutrition 2013 v.110 no.3 pp. 391-400
ISSN:
1475-2662
Subject:
DNA; active ingredients; antioxidant activity; cell movement; cyclin-dependent kinase; cyclins; cytotoxicity; dissociation; dose response; humans; interphase; licorice; long term effects; medicinal properties; microfilaments; models; myocytes; phosphorylation; phytopharmaceuticals; platelet-derived growth factor; rats; smooth muscle; thymidine; traditional medicine
Abstract:
... Liquorice is one of the botanicals used frequently as a traditional medicine in the West and in the East. Platelet-derived growth factor (PDGF)-BB is involved in the development of CVD by inducing abnormal proliferation and migration of vascular smooth muscle cells. In our preliminary study, dehydroglyasperin C (DGC), an active compound of liquorice, showed strong antioxidant activity. Since phyto ...
DOI:
10.1017/S0007114512005399
PubMed:
23298457

11. Development of Next Generation Stevia Sweetener: Rebaudioside M

Author:
Indra Prakash; Avetik Markosyan; Cynthia Bunders
Source:
Foods 2014 v.3 no.1 pp. 162-175
ISSN:
2304-8158
Subject:
Stevia rebaudiana; aqueous solutions; beverages; food industry; glycosides; licorice; mixing; models; pH; sensory evaluation; steviol; sucrose; sweetness; taste sensitivity
Abstract:
... This work aims to review and showcase the unique properties of rebaudioside M as a natural non-caloric potential sweetener in food and beverage products. To determine the potential of rebaudioside M, isolated from Stevia rebaudiana Bertoni, as a high potency sweetener, we examined it with the Beidler Model. This model estimated that rebaudioside M is 200–350 times more potent than sucrose. Numerou ...
DOI:
10.3390/foods3010162
PubMed:
28234311
PubMed Central:
PMC5302307

12. Dietary compound glycyrrhetinic acid suppresses tumor angiogenesis and growth by modulating antiangiogenic and proapoptotic pathways in vitro and in vivo

Author:
Jingjing Li; Fan Tang; Renkai Li; Zhejie Chen; Simon Ming-Yuen Lee; Chaomei Fu; Jinming Zhang; George Pak-Heng Leung
Source:
Journal of nutritional biochemistry 2020 v.77 pp. 108268
ISSN:
0955-2863
Subject:
Danio rerio; angiogenesis; animal ovaries; antineoplastic activity; apoptosis; bioactive compounds; blood vessels; caspase-3; caspase-9; cell cycle checkpoints; cyclins; ex vivo studies; glycyrrhetinic acid; human umbilical vein endothelial cells; in vitro studies; in vivo studies; interphase; licorice; mechanism of action; membrane potential; mice; mitochondrial membrane; mitogen-activated protein kinase; models; neoplasm cells; ovarian neoplasms; phosphorylation; pro-apoptotic proteins; rats; receptors; signal transduction; vascular endothelial growth factor receptor-2
Abstract:
... Glycyrrhetinic acid (GA) is a major bioactive compound of licorice. The objective of this study was to investigate the effects of GA on ovarian cancer, particularly those related to angiogenesis and apoptosis, and to elucidate the underlying mechanisms of action. In vitro studies showed that GA significantly inhibited proliferation, migration, invasion and tube formation in human umbilical vein en ...
DOI:
10.1016/j.jnutbio.2019.108268

13. Dietary licorice root supplementation reduces diet‐induced weight gain, lipid deposition, and hepatic steatosis in ovariectomized mice without stimulating reproductive tissues and mammary gland

Author:
Zeynep Madak‐Erdogan; Ping Gong; Yiru Chen Zhao; Liwen Xu; Kinga U. Wrobel; James A. Hartman; Michelle Wang; Anthony Cam; Urszula T. Iwaniec; Russell T. Turner; Nathan C. Twaddle; Daniel R. Doerge; Ikhlas A. Khan; John A. Katzenellenbogen; Benita S. Katzenellenbogen; William G. Helferich
Source:
Molecular nutrition & food research 2016 v.60 no.2 pp. 369-380
ISSN:
1613-4125
Subject:
blood; body weight changes; bone density; dietary supplements; dual-energy X-ray absorptiometry; fatty liver; food consumption; gene expression; genes; high fat diet; licorice; liver; magnetic resonance imaging; mammary glands; menopause; metabolism; mice; models; obesity; ovariectomy; phenotype; subcutaneous fat; uterus; weight gain
Abstract:
... SCOPE: We studied the impact of dietary supplementation with licorice root components on diet‐induced obesity, fat accumulation, and hepatic steatosis in ovariectomized C57BL/6 mice as a menopause model. MATERIALS AND METHODS: We evaluated the molecular and physiological effects of dietary licorice root administered to ovariectomized C57BL/6 mice as root powder (LRP), extracts (LRE), or isolated i ...
DOI:
10.1002/mnfr.201500445
PubMed:
26555669
PubMed Central:
PMC4738101

14. Effects of herbal drugs in Mahuang decoction and their main components on intestinal transport characteristics of Ephedra alkaloids evaluated by a Caco-2 cell monolayer model

Author:
Mengkai Zheng; Huifen Zhou; Haitong Wan; Yu-Lin Chen; Yu He
Source:
Journal of ethnopharmacology 2015 v.164 pp. 22-29
ISSN:
0378-8741
Subject:
Cassia; Ephedra; Oriental traditional medicine; P-glycoproteins; absorption; alkaloids; amygdalin; apricots; branches; essential oils; glomerulonephritis; herbal medicines; human cell lines; ingredients; intestinal absorption; licorice; models; permeability; pseudoephedrine; renal failure; respiratory tract diseases; seeds; therapeutics; toxicity; verapamil
Abstract:
... Mahuang decoction, Ephedra combined with Cassia twig, Bitter apricot kernel and Prepared licorice, has been widely used as a multi-herb prescription in traditional Chinese medicine (TCM). Many modern pharmacological studies have shown that the compatibility application of these four herbs has promising therapeutic effects on respiratory infection, acute glomerulonephritis and chronic renal failure ...
DOI:
10.1016/j.jep.2015.01.043

15. Evaluation of nickel stabilization in a calcareous soil amended with biochars using mathematical adsorption models

Author:
Hamid Reza Boostani; Mahdi Najafi-Ghiri; Ailsa G. Hardie
Source:
Communications in soil science and plant analysis 2020 v.51 no.9 pp. 1213-1226
ISSN:
1532-2416
Subject:
adsorption; biochar; calcareous soils; corn straw; endothermy; licorice; models; nickel; phosphorus; plant analysis; pulp; rice hulls; sorption isotherms; thermodynamics; wheat straw
Abstract:
... Batch adsorption experiments were performed to investigate the effect of different biochars (corn straw biochar (S-CSB), wheat straw biochar (S-WSB), rice husk biochar (S-RHB) and licorice root pulp biochar (S-LRB) each at 3% w/w) application on the kinetics, isotherms and thermodynamic parameters of nickel (Ni) adsorption onto a calcareous soil. The kinetics of Ni adsorption as a function of time ...
DOI:
10.1080/00103624.2020.1763382

16. Evaluation of the value of near infrared (NIR) spectromicroscopy for the analysis of glycyrrizhic acid in licorice

Author:
Zhi-Sheng WU; Lu-Wei ZHOU; Sheng-Yun DAI; Xin-Yuan SHI; Yan-Jiang QIAO
Source:
Chinese journal of natural medicines 2015 v.13 no.4 pp. 316-320
ISSN:
1875-5364
Subject:
Glycyrrhiza uralensis; Oriental traditional medicine; glycyrrhizin; least squares; licorice; medicinal plants; models; near-infrared spectroscopy; prediction
Abstract:
... It has been reported that hyperspectral data could be employed to qualitatively elucidate the spatial composition of tablets of Chinese medicinal plants. To gain more insights into this technology, a quantitative profile provided by near infrared (NIR) spectromicroscopy was further studied by determining the glycyrrhizic acid content in licorice, Glycyrrhiza uralensis. Thirty-nine samples from twe ...
DOI:
10.1016/S1875-5364(15)30022-4

17. Focusing and non-focusing modulation strategies for the improvement of on-line two-dimensional hydrophilic interaction chromatography × reversed phase profiling of complex food samples

Author:
Lidia Montero; Elena Ibáñez; Mariateresa Russo; Luca Rastrelli; Alejandro Cifuentes; Miguel Herrero
Source:
Analytica chimica acta 2017 pp. -
ISSN:
0003-2670
Subject:
analytical chemistry; comprehensive two-dimensional liquid chromatography; food analysis; hydrophilic interaction chromatography; licorice; models; solvents
Abstract:
... Comprehensive two-dimensional liquid chromatography (LC × LC) is ever gaining interest in food analysis, as often, food-related samples are too complex to be analyzed through one-dimensional approaches. The use of hydrophilic interaction chromatography (HILIC) combined with reversed phase (RP) separations has already been demonstrated as a very orthogonal combination, which allows attaining increa ...
DOI:
10.1016/j.aca.2017.07.013

18. Formulation of Glycyrrhizic Acid-based Nanocomplexes for Enhanced Anti-cancer and Anti-inflammatory Effects of Curcumin

Author:
Jihyeon Song; Jun Yeong Kim; Gayeon You; Yoon Young Kang; Jiwon Yang; Hyejung Mok
Source:
Biotechnology and bioprocess engineering 2022 v.27 no.2 pp. 163-170
ISSN:
1226-8372
Subject:
Glycyrrhiza glabra; aqueous solutions; bioprocessing; biotechnology; blood serum; breast neoplasms; curcumin; glycyrrhizin; humans; hydrophobicity; licorice; macrophages; models; necrosis; rheumatoid arthritis; solubility; sonication; splenomegaly; Michigan
Abstract:
... In this study, nanocomplexes composed of glycyrrhizic acid (GA) derived from the root of the licorice plant (Glycyrrhiza glabra) were formulated for the delivery of curcumin (CUR). Sonication of amphiphilic GA solution with hydrophobic CUR resulted in the production of nanosized complexes with a size of 164.8 ± 51.7 nm, which greatly enhanced the solubility of CUR in aqueous solution. A majority o ...
DOI:
10.1007/s12257-021-0198-7

19. Glabridin Protects Paraoxonase 1 from Linoleic Acid Hydroperoxide Inhibition via Specific Interaction: A Fluorescence-Quenching Study

Author:
Atrahimovich Dana; Vaya Jacob; Tavori Hagai; Khatib Soliman
Source:
Journal of agricultural and food chemistry 2012 v.60 no.14 pp. 3679-3685
ISSN:
1520-5118
Subject:
antioxidant activity; antioxidants; ascorbic acid; fluorescence; high density lipoprotein; humans; hydrophobicity; licorice; linoleic acid; models; oxidation; thiols
Abstract:
... The enzyme paraoxonase 1 (PON1) binds to high-density lipoprotein (HDL) and is responsible for many of HDL’s antiatherogenic properties. We previously showed that recombinant PON1 is inhibited by linoleic acid hydroperoxide (LA-OOH) present in the lipid fraction of the human carotid plaque (LLE) via oxidation of the enzyme’s Cys284 thiol. Here we explore the effect of glabridin, an isoflavan isola ...
DOI:
10.1021/jf2046009
PubMed:
22380866

20. Glycerolic Licorice Extracts as Active Cosmeceutical Ingredients: Extraction Optimization, Chemical Characterization, and Biological Activity

Author:
Petar Ciganović; Katarzyna Jakimiuk; Michał Tomczyk; Marijana Zovko Končić
Source:
Antioxidants 2019 v.8 no.10 pp. -
ISSN:
2076-3921
Subject:
Glycyrrhiza glabra; anti-aging properties; anti-inflammatory activity; antioxidant activity; cosmetics; elastase; enzyme inhibition; experimental design; glycerol; herbal medicines; ingredients; iron; licorice; models; phenols; response surface methodology; solvents; temperature; ultrasonic treatment
Abstract:
... A green ultrasound-assisted extraction (UAE) method using glycerol/water mixtures for extraction of licorice (Glycyrrhiza glabra) bioactive constituents was developed in this study. The response surface method, according to the Box-Behnken design, was employed to optimize the extraction parameters: glycerol concentration (X1), temperature (X2), and the amount of herbal drug u ...
DOI:
10.3390/antiox8100445
PubMed:
31581512
PubMed Central:
PMC6826613

21. Glycycoumarin Sensitizes Liver Cancer Cells to ABT-737 by Targeting De Novo Lipogenesis and TOPK-Survivin Axis

Author:
Enxiang Zhang; Shutao Yin; Xiaotong Lu; Linhu Ye; Lihong Fan; Hongbo Hu
Source:
Nutrients 2018 v.10 no.3 pp. -
ISSN:
2072-6643
Subject:
cell lines; coumarin; licorice; lipogenesis; liver neoplasms; medicinal plants; models; neoplasm cells; protein kinases; therapeutics; toxicity
Abstract:
... Glycycoumarin (GCM) is a representative of bioactive coumarin compounds isolated from licorice, an edible and medicinal plant widely used for treating various diseases including liver diseases. The purpose of the present study is to examine the possibility of GCM as a sensitizer to improve the efficacy of BH3 mimetic ABT-737 against liver cancer. Three liver cancer cell lines (HepG2, Huh-7 and SMM ...
DOI:
10.3390/nu10030353
PubMed:
29543705
PubMed Central:
PMC5872771

22. Glycyrrhizic Acid and 18β-Glycyrrhetinic Acid Modulate Lipopolysaccharide-Induced Inflammatory Response by Suppression of NF-κB through PI3K p110δ and p110γ Inhibitions

Author:
Wang, Chung-Yi; Kao, Tzu-Chien; Lo, Wen-Hsieh; Yen, Gow-Chin
Source:
Journal of agricultural and food chemistry 2011 v.59 no.14 pp. 7726-7733
ISSN:
0021-8561
Subject:
Western blotting; anti-inflammatory activity; cell viability; genes; glycyrrhizin; herbal medicines; inflammation; interleukin-1; licorice; lipopolysaccharides; macrophages; messenger RNA; models; necrosis; nitric oxide; phosphatidylinositol 3-kinase; prostaglandins; reactive oxygen species; reverse transcriptase polymerase chain reaction; rhizomes; roots; sweeteners; transcription factor NF-kappa B
Abstract:
... The roots and rhizomes of licorice (Glycyrrhia) species have been used extensively as natural sweeteners and herbal medicines. The aim of this work was to determine the in vitro anti-inflammatory effects of glycyrrhizic acid (GA) and 18β-glycyrrhetinic acid (18βGA) from licorice in a lipopolysaccharide (LPS)-stimulated macrophage model. The results showed that treatment with 25 75 μMGAor 18βGA did ...
DOI:
10.1021/jf2013265
PubMed:
21644799

23. Glycyrrhizic acid and 18β-glycyrrhetinic acid recover glucocorticoid resistance via PI3K-induced AP1, CRE and NFAT activation

Author:
Tzu-Chien Kao; Chi-Hao Wu; Gow-Chin Yen
Source:
Phytomedicine 2013 v.20 pp. 295-302
ISSN:
0944-7113
Subject:
Oriental traditional medicine; T-lymphocytes; antagonists; anti-inflammatory activity; antioxidant activity; asthma; cyclic AMP; glucocorticoid receptors; glucocorticoids; glycyrrhizin; licorice; models; nitric oxide; patients; phosphatidylinositol 3-kinase; phytopharmaceuticals; prognosis; reactive oxygen species; therapeutics; transcriptional activation
Abstract:
... Glucocorticoids are widely used in the clinical setting as remedies for inflammatory diseases, such as asthma and chronic obstructive pulmonary disease. However, the constant increase in the number of patients suffering from glucocorticoid resistance could present a serious problem for clinicians. In these cases, it may be reasonable to use additional treatments to restore the therapeutic effect o ...
DOI:
10.1016/j.phymed.2012.10.013

24. Glycyrrhizin Improves Fatty Liver Symptoms, Increases Adiponectin and Reduces UCP2 Expression in Wistar Rats

Author:
Hamedeh Bagheri; Parichehreh Yaghmaei; Mohamadhosein Modaresi; Marjan Sabbaghian; Azadeh Ebrahim-Habibi
Source:
Proceedings of the National Academy of Sciences, India, Section B: biological sciences 2020 v.90 no.1 pp. 191-197
ISSN:
0369-8211
Subject:
adiponectin; bioactive compounds; body weight; catalase; fatty liver; gene expression; glucose; glycyrrhizin; high fat diet; histology; insulin; licorice; lipid composition; liver; liver cirrhosis; males; metabolic syndrome; models; rats; superoxide dismutase; India
Abstract:
... Glycyrrhizin (GL) is the main bioactive component in the extract of licorice root, with beneficial effects on metabolic syndrome. This study investigates the effect of GL on biochemical and histological parameters and UCP2 gene expression in a rodent nonalcoholic steatosis model. Thirty-two male Wistar rats were classified into four groups randomly: control (normal diet with standard rat chow), hi ...
DOI:
10.1007/s40011-019-01097-7

25. Glycyrrhizin inhibits osteoarthritis development through suppressing the PI3K/AKT/NF-κB signaling pathway in vivo and in vitro

Author:
Ren-Hao Jiang; Jia-Jing Xu; Ding-Chao Zhu; Jia-Feng Li; Chen-Xi Zhang; Nan Lin; Wei-Yang Gao
Source:
Food & function 2020 v.11 no.3 pp. 2126-2136
ISSN:
2042-650X
Subject:
anti-inflammatory activity; antioxidant activity; cartilage; chondrocytes; collagen; elderly; glycyrrhizin; humans; inducible nitric oxide synthase; interleukin-6; licorice; metalloproteinases; mice; models; nitric oxide; osteoarthritis; phosphatidylinositol 3-kinase; phosphorylation; prostaglandin synthase; prostaglandins; signal transduction; therapeutics; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:
... Osteoarthritis (OA) is a serious and frequently occurring disease in the elderly, characterized by cartilage degeneration and proliferation of bone structure. Glycyrrhizin, a compound extracted from licorice, has been reported to have various important biological activities, such as antioxidant properties and anti-inflammatory action. However, it has not been reported whether glycyrrhizin has a po ...
DOI:
10.1039/c9fo02241d

26. HuR-mediated posttranscriptional regulation of p21 is involved in the effect of Glycyrrhiza uralensis licorice aqueous extract on polyamine-depleted intestinal crypt cells proliferation

Author:
Yi He; Xian Zhang; Xing Zeng; Yu Huang; Jian-An Wei; Ling Han; Cai-Xia Li; Guo-Wei Zhang
Source:
Journal of nutritional biochemistry 2012 v.23 no.10 pp. 1285-1293
ISSN:
0955-2863
Subject:
Glycyrrhiza uralensis; alpha-difluoromethylornithine; biotin; cell cycle; cell proliferation; food additives; gene expression; intestinal mucosa; licorice; luciferase; medicine; messenger RNA; models; stem cells
Abstract:
... Glycyrrhiza uralensis licorice has long been used worldwide as a food additive and herbal medicine. It possesses a remarkable healing action on gastrointestinal ulcers. The present study was carried out to assess the effect of licorice on intestinal crypt cell proliferation and to investigate the corresponding molecular mechanism. Considering the role of crypt stem cells in intestinal mucosa repai ...
DOI:
10.1016/j.jnutbio.2011.07.009
PubMed:
22217517

27. Immunoregulatory effects of Glycyrrhizic acid exerts anti-asthmatic effects via modulation of Th1/Th2 cytokines and enhancement of CD4⁺CD25⁺Foxp3⁺ regulatory T cells in ovalbumin-sensitized mice

Author:
Chunhua Ma; Zhanqiang Ma; Xiao-lin Liao; Jiping Liu; Qiang Fu; Shiping Ma
Source:
Journal of ethnopharmacology 2013 v.148 no.3 pp. 755-762
ISSN:
0378-8741
Subject:
Glycyrrhiza glabra; T-lymphocytes; Western blotting; asthma; dexamethasone; enzyme-linked immunosorbent assay; eosinophilia; flow cytometry; glycyrrhizin; ingredients; interferon-gamma; interleukin-5; licorice; medicinal properties; mice; models; patients; therapeutics; transcription factors
Abstract:
... ETHNOPHARMACOLOGICAL RELEVANCE: Glycyrrhizic acid (GA) is the main bioactive ingredient of licorice (Glycyrrhiza glabra), and has been found to be associated with multiple therapeutic properties. AIM OF THE STUDY: In this study, we investigated immunoregulatory effects of glycyrrhizic acid on anti-asthmatic effects and underlying mechanisms. MATERIALS AND METHODS: Asthma model was established by o ...
DOI:
10.1016/j.jep.2013.04.021

28. Impacts of Imazapyr and Triclopyr Soil Residues on the Growth of Several Restoration Species

Author:
Cameron H. Douglass; Scott J. Nissen; Paul J. Meiman; Andrew R. Kniss
Source:
Rangeland ecology & management 2016 v.69 no.3 pp. 199-205
ISSN:
1550-7424
Subject:
Bouteloua curtipendula; Elymus trachycaulus; Pascopyrum smithii; Sporobolus airoides; Tamarix; anthropogenic activities; dose response; ecosystems; grasses; half life; herbicide residues; herbicide resistance; high performance liquid chromatography; highlands; imazapyr; in vitro studies; invasive species; licorice; managers; models; perennial weeds; planting; rangelands; soil properties; soil types; triclopyr; woody plants; Colorado
Abstract:
... Herbicides are frequently used in natural systems to control invasive plants, but nontarget impacts from persistent soil residues can result in unintended ecosystem effects. Imazapyr and triclopyr are herbicides that are widely used in noncrop areas such as rangelands to manage perennial weeds, especially woody species such as tamarisk (saltcedar). Due to widespread environmental and anthropogenic ...
DOI:
10.1016/j.rama.2016.01.006

29. Influences of vanillin and licorice root extract supplementations on the decimal reduction times of Escherichia coli O157:H7 in mildly heated young coconut liquid endosperm

Author:
Alonzo A. Gabriel; Jennifer Karen F. Pineda
Source:
Food control 2014 v.38 pp. 136-141
ISSN:
0956-7135
Subject:
Escherichia coli O157; additives; coconuts; consumer acceptance; endosperm; heat; licorice; models; pasteurization; quality control; vanillin
Abstract:
... This study determined the influences of supplementing different combinations of vanillin (0–500 ppm) and licorice root extract (LRE, 0–420 ppm) on the mild heat (55 °C) decimal reduction times (D55-values) of a cocktail of Escherichia coli O157:H7 in young coconut liquid endosperm. The maximum level of supplementation per additive tested was previously established not to result in the lowering of ...
DOI:
10.1016/j.foodcont.2013.10.011

30. Laminaria japonica increases plasma exposure of glycyrrhetinic acid following oral administration of Liquorice extract in rats

Author:
Wei-Man ZHAO; Shu-Wen JIANG; Yang CHEN; Ze-Yu ZHONG; Zhong-Jian WANG; Mian ZHANG; Ying LI; Ping XU; Li LIU; Xiao-Dong LIU
Source:
Chinese journal of natural medicines 2015 v.13 no.7 pp. 540-549
ISSN:
1875-5364
Subject:
Laminaria; Oriental traditional medicine; Saccharina japonica; absorption; duodenum; glycyrrhizin; intestinal absorption; jejunum; large intestine; licorice; liquid chromatography; mass spectrometry; models; oral administration; pharmacokinetics; rats
Abstract:
... The present study was designed to investigate the effects of Laminaria japonica (Laminaria) on pharmacokinetics of glycyrrhetinic acid (GA) following oral administration of Liquorice extract in rats. Following oral administrations of single-dose and multi-dose Liquorice extract and Liquorice-Laminaria extract, respectively, plasma samples were obtained at various times and the concentrations of GA ...
DOI:
10.1016/S1875-5364(15)30049-2

31. Licochalcone A Inhibits Lipopolysaccharide-Induced Inflammatory Response in Vitro and in Vivo

Author:
Chu Xiao; Ci Xinxin; Wei Miaomiao; Yang Xiaofeng; Cao Qingjun; Guan Mingfeng; Li Hongyu; Deng Yanhong; Feng Haihua; Deng Xuming
Source:
Journal of agricultural and food chemistry 2012 v.60 no.15 pp. 3947-3954
ISSN:
1520-5118
Subject:
Glycyrrhiza glabra; Western blotting; anti-inflammatory activity; antimicrobial properties; cell proliferation; edema; enzyme-linked immunosorbent assay; hemorrhage; inflammation; interleukin-1; interleukin-6; licorice; mice; mitogen-activated protein kinase; models; phosphorylation; tumor necrosis factor-alpha
Abstract:
... Licochalcone A (Lico A), a flavonoid found in licorice root (Glycyrrhiza glabra), is known for its antimicrobial activity and its reported ability to inhibit cancer cell proliferation. In the present study, we found that Lico A exerted potent anti-inflammatory effects in in vitro and in vivo models induced by lipopolysaccharide (LPS). The concentrations of TNF-α, interleukin (IL)-6, and IL-1β in t ...
DOI:
10.1021/jf2051587
PubMed:
22400806

32. Licochalcone A attenuates glioma cell growth in vitro and in vivo through cell cycle arrest

Author:
Wan Jung LuThese authors contributed equally to this manuscript.; Gong Jhe Wu; Ray Jade Chen; Chao Chien Chang; Li Ming Lien; Ching Chuan Chiu; Mei Fang Tseng; Li Ting Huang; Kuan Hung Lin
Source:
Food & function 2018 v.9 no.8 pp. 4500-4507
ISSN:
2042-650X
Subject:
active ingredients; anti-inflammatory activity; antineoplastic activity; brain; cell cycle checkpoints; cell growth; cyclin-dependent kinase; cyclins; glioblastoma; licorice; messenger RNA; models; neoplasm cells; protein content
Abstract:
... Licochalcone A (LA), an active ingredient of licorice, has multiple biological activities, including antioxidative and anti-inflammatory activities. Although LA exerts antitumor effects in various cancer cells, its role in gliomas remains unclear. Therefore, this study determined whether LA inhibits glioma cell growth in vitro and in vivo. The present data revealed that LA effectively inhibited th ...
DOI:
10.1039/c8fo00728d

33. Licochalcone A reverses NNK-induced ectopic miRNA expression to elicit in vitro and in vivo chemopreventive effects

Author:
Bingxin Li; Di Zhou; Shuang Li; Yuan Feng; Xingyu Li; Wenhui Chang; Juan Zhang; Yu Sun; Degang Qing; Gang Chen; Ning Li
Source:
Phytomedicine 2020 v.76 pp. 153245
ISSN:
0944-7113
Subject:
apoptosis; biomarkers; cell cycle; chemoprevention; cost effectiveness; intraperitoneal injection; lung neoplasms; microRNA; models; pathogenesis
Abstract:
... Chemoprevention is the best cost-effective way regarding cancers. MicroRNAs (miRNAs) have been reported to be differentially expressed during the development of lung cancer. However, if lung cancer prevention can be achieved through modulating miRNAs expression so far remains unknown.To discover ectopically expressed miRNAs in NNK-induced lung cancer and clarify whether Licochalcone A (lico A) can ...
DOI:
10.1016/j.phymed.2020.153245

34. Licoricidin improves neurological dysfunction after traumatic brain injury in mice via regulating FoxO3/Wnt/β-catenin pathway

Author:
Cai Liu; Dongqiang He; Qiming Zhao
Source:
Natural medicines 2020 v.74 no.4 pp. 767-776
ISSN:
1340-3443
Subject:
Western blotting; antioxidant activity; apoptosis; brain; brain damage; catalase; death; drugs; edema; fluorescent antibody technique; glutathione peroxidase; licorice; males; malondialdehyde; models; neuroprotective effect; nucleotidyltransferases; phosphorylation; superoxide dismutase; therapeutics
Abstract:
... Traumatic brain injury (TBI) is a major cause of death and disability around the world with no effective treatments currently. The present study was aimed to investigate the neuroprotective effect of licoricidin, one of the major components of licorice extract, on TBI mice and further explore the underlying mechanism. Male C57BL/6 mice were modeled by a modified weight-drop method to mimic TBI. Al ...
DOI:
10.1007/s11418-020-01434-5

35. Mechanisms of traditional Chinese medicines in the treatment of allergic rhinitis using a network biology approach

Author:
Li Du; Xiaotong Ye; Manman Li; Huihui Wang; Baixia Zhang; Rao Zheng; Yun Wang
Source:
Journal of traditional Chinese medical sciences 2021 v.8 no.1 pp. 82-89
ISSN:
2095-7548
Subject:
CD4-positive T-lymphocytes; Cicadidae; Cynanchum; allergic rhinitis; anti-allergic agents; antigens; bioinformatics; cell membranes; cell proliferation; databases; drug development; flowers; fruits; histamine; immunoglobulin E; interleukin-13; interleukin-4; licorice; models
Abstract:
... To systematically explore the effect and mechanism of traditional Chinese herbs in the treatment of allergic rhinitis.Magnolia flower, xanthium fruit, astragalus root, paniculate cynanchum, scutellaria root, cicada molting, stephania root, small centipeda herb, and licorice root as traditional Chinese herbs are widely used to treat allergic rhinitis. With multiple database integration and entity g ...
DOI:
10.1016/j.jtcms.2016.11.007

36. Metabolite Profiling and Classification of DNA-Authenticated Licorice Botanicals

Author:
Simmler Charlotte; Anderson Jeffrey R.; Gauthier Laura; Lankin David C.; McAlpine James B.; Chen Shao-Nong; Pauli Guido F.
Source:
Journal of natural products 2015 v.78 no.8 pp. 2007-2022
ISSN:
1520-6025
Subject:
DNA; Glycyrrhiza glabra; Glycyrrhiza inflata; Glycyrrhiza uralensis; chalcones; chemometrics; dietary supplements; discriminant analysis; flavanones; hybrids; licorice; metabolites; metabolomics; models; nuclear magnetic resonance spectroscopy; phenolic compounds; principal component analysis; quality control; roots
Abstract:
... Raw licorice roots represent heterogeneous materials obtained from mainly three Glycyrrhiza species. G. glabra, G. uralensis, and G. inflata exhibit marked metabolite differences in terms of flavanones (Fs), chalcones (Cs), and other phenolic constituents. The principal objective of this work was to develop complementary chemometric models for the metabolite profiling, classification, and quality ...
DOI:
10.1021/acs.jnatprod.5b00342
PubMed:
26244884
PubMed Central:
PMC4553119

37. Metabolomics analysis highlights Yashtimadhu (Glycyrrhiza glabra L.)‐mediated neuroprotection in a rotenone‐induced cellular model of Parkinson's disease by restoring the mTORC1‐AMPK1 axis in autophagic regulation

Author:
Gayathree Karthikkeyan; Santosh Kumar Behera; Shubham Sukerndeo Upadhyay; Ravishankar Pervaje; Thottethodi Subrahmanya Keshava Prasad; Prashant Kumar Modi
Source:
Phytotherapy research 2022 v.36 no.5 pp. 2207-2222
ISSN:
0951-418X
Subject:
Glycyrrhiza glabra; Parkinson disease; autophagy; energy; licorice; mass spectrometry; metabolism; metabolites; metabolomics; models; neuroprotective effect; phytotherapy; research; rotenone; succinic acid; traditional medicine; tricarboxylic acid cycle
Abstract:
... Parkinson's disease (PD) is an age‐associated progressive neurodegenerative movement disorder, and its management strategies are known to cause complications with prolonged usage. We aimed to explore the neuroprotective mechanism of the Indian traditional medicine Yashtimadhu, prepared from the dried roots of Glycyrrhiza glabra L. (licorice) in the rotenone‐induced cellular model of PD. Retinoic a ...
DOI:
10.1002/ptr.7449

38. Method validation for the analysis of licorice acid in the blending process by near infrared diffuse reflectance spectroscopy

Author:
Zhong Xue; Bing Xu; Chan Yang; Xianglong Cui; Jianyu Li; Xinyuan Shi; Yanjiang Qiao
Source:
Analytical methods 2015 v.7 no.14 pp. 5830-5837
ISSN:
1759-9679
Subject:
chemometrics; guidelines; least squares; licorice; mixing; models; near-infrared spectroscopy; reflectance spectroscopy; risk; talc
Abstract:
... The present work describes the validation of the near infrared (NIR) method for the quantification of the concentration of licorice acid in the blending process of licorice and talcum powder mixtures. The NIR diffuse reflectance spectra of samples were collected during the mixing process and the partial least squares (PLS) model was developed. The accuracy profile (AP) approach that was fully comp ...
DOI:
10.1039/c5ay01289a

39. Microwave Drying Kinetics of a Thin-Layer Liquorice Root

Author:
Asım Balbay; Ömer Şahin
Source:
Drying technology 2012 v.30 no.8 pp. 859-864
ISSN:
1532-2300
Subject:
activation energy; diffusivity; drying; licorice; medicinal plants; models; temperature; water content
Abstract:
... Liquorice root (LR) (Glycyrrize glabra) is known as a sweetener and medicine plant. Drying kinetics of LR with initial moisture content of 49.5% (wet basis (w.b)) were experimentally investigated in a microwave drying system. The drying experiments were carried out at different drying temperatures (40, 45, 50, and 55°C) and microwave power levels (250, 500 and 750 W). Several models from literatur ...
DOI:
10.1080/07373937.2012.670682

40. Molecular and structural insights of β-boswellic acid and glycyrrhizic acid as potent SARS-CoV-2 Envelope protein inhibitors

Author:
Syeda Warisul Fatima; Shahenvaz Alam; Sunil K. Khare
Source:
Phytomedicine plus 2022 v.2 no.2 pp. 100241
ISSN:
2667-0313
Subject:
Boswellia; Glycyrrhiza; Internet; Severe acute respiratory syndrome coronavirus 2; antiviral properties; computer software; drug design; fluorescence; glycyrrhizin; licorice; ligands; models; therapeutics; toxicity testing; triterpenoids; viruses
Abstract:
... Over million people have been infected with SARS-CoV-2 virus worldwide, with around 3% reported deaths till date. A few conventional antiviral treatments have been tried to mitigate the coronavirus. However, many alternative therapeutics are being evaluated worldwide. In the present study, we investigated traditional Indian medicinal compounds antiviral potencies as an effective drug for targeting ...
DOI:
10.1016/j.phyplu.2022.100241

41. Nasal irrigation with Glycyrrhiza glabra extract for treatment of allergic rhinitis – A study of in vitro, in vivo and clinical trial

Author:
Geng-He Chang; Yu-Shih Lin; Ke-Hsin Hsu; Yu-Ching Cheng; Pei-Rung Yang; Ming-Shao Tsai; Yao-Te Tsai; Cheng-Ming Hsu; Pey-Jium Chang; Chung-Sheng Shi; Yao-Hsu Yang; Ching-Yuan Wu
Source:
Journal of ethnopharmacology 2021 v.275 pp. 114116
ISSN:
0378-8741
Subject:
Glycyrrhiza glabra; Oriental traditional medicine; acoustics; adrenal cortex hormones; allergic rhinitis; anaphylaxis; anti-allergic agents; anti-inflammatory activity; calcium; clinical trials; hypertrophy; irrigation; licorice; mast cells; models; nose; pruritus; rhinoscopy; smell; sweetness
Abstract:
... Glycyrrhiza glabra, a family of licorice and a traditional Chinese medicine with sweet taste and favorable smell, has anti-inflammatory, anti-allergic and immunomodulatory functions.Aim of the study: We developed a licorice extract (LE) by using glycyrrhiza glabra and administered it through nasal irrigation to treat allergic rhinitis (AR).LE was prepared into extract powder, and the anti-inflamma ...
DOI:
10.1016/j.jep.2021.114116

42. Pharmacokinetic study of liquiritin in rat serum using molecularly imprinted solid-phase extraction combined with RP-HPLC

Author:
Huang Yang; Li Kang; Shao Hui Kai; Liu Sheng Quan; Xiang Fei Jun
Source:
Analytical methods 2014 v.6 no.5 pp. 1563-1568
ISSN:
1759-9679
Subject:
acrylamides; blood serum; ethylene glycol; licorice; models; molecular imprinting; oral administration; pharmacokinetics; polymerization; polymers; rats; reversed-phase high performance liquid chromatography; solid phase extraction
Abstract:
... A method using molecularly imprinted solid-phase extraction combined with RP-HPLC-UV was developed for determination of liquiritin (LQR) in rat plasma after oral administration of Compound Liquorice Tablets (CLTs). To this end, molecularly imprinted polymers were prepared by in situ polymerization, using LQR as the template, acrylamide as the functional monomer, and ethylene glycol dimethacrylate ...
DOI:
10.1039/c3ay42084a

43. Potential detoxification effect of active ingredients in liquorice by upregulating efflux transporter

Author:
Yufei He; Xiaoyan Ci; Ying Xie; Xiulin Yi; Yong Zeng; Yazhuo Li; Changxiao Liu
Source:
Phytomedicine 2019 v.56 pp. 175-182
ISSN:
0944-7113
Subject:
P-glycoproteins; Western blotting; absorption; active ingredients; analgesics; flavonoids; flow cytometry; fluorescence; gene expression; herbal medicines; human cell lines; intestines; licorice; medicinal properties; messenger RNA; models; protein synthesis; reverse transcriptase polymerase chain reaction; rhodamines; saponins; triterpenoids; xenobiotics
Abstract:
... As one of most widely used herbal medicine, liquorice exhibits diverse pharmacological activities, for instance, analgesic, antitussive, antiarrhythmic, anti-inflammatory, and immune regulation. Additionally, detoxification effects were observed in combination of liquorice with other herbal drugs. The mechanism of detoxification of liquorice has been extensively investigated through material basis ...
DOI:
10.1016/j.phymed.2018.10.033

44. Potential role of mTORC1 and the PI3K-Akt pathway in anti-acne properties of licorice flavonoids

Author:
ShiFa Ruan; ShiJian Xiang; WenFeng Wu; SiWei Cao; QunQun Du; ZhuXian Wang; TingTing Chen; Qun Shen; Li Liu; HuoJi Chen; LiDong Weng; HongXia Zhu; Qiang Liu
Source:
Journal of functional foods 2020 v.70 pp. 103968
ISSN:
1756-4646
Subject:
Western blotting; acne; bioinformatics; flavonoids; focal adhesions; gene expression regulation; leukocytes; licorice; microfilaments; mitochondria; models; protein synthesis; proteomics; quantitative polymerase chain reaction; rats; reverse transcriptase polymerase chain reaction; signal transduction; tight junctions
Abstract:
... We applied a label-free proteomic method to explore the mechanisms of Licorice flavonoid anti-acne effects in rat. Acne model was established in the back of rats as model group (MDL), then treated with licorice flavonoid (LCF), while none treated rats as control groups (CTR). In MDL, 314 differentially expressed proteins (DEPs) and 27 significantly differentially expressed proteins (SDEPs) were id ...
DOI:
10.1016/j.jff.2020.103968

45. Preclinical studies of licorice in ulcerative colitis: A systematic review with meta-analysis and network pharmacology

Author:
Peng-De Lu; Meng-Chen Yuan; Xing-Ping Quan; Jin-Fen Chen; Yong-Hua Zhao
Source:
Journal of ethnopharmacology 2022 v.296 pp. 115444
ISSN:
0378-8741
Subject:
Oriental traditional medicine; antitussive agents; clinical trials; histology; homeostasis; immunomodulators; inflammation; licorice; meta-analysis; microorganisms; models; pain; pharmacology; risk; sample size; spleen; systematic review; therapeutics; ulcerative colitis
Abstract:
... Licorice, as a traditional Chinese herbal medicine, possessing the efficacies of invigorating spleen and replenishing qi, heat-clearing and detoxicating, phlegm-resolving and cough suppressant, relieving spasm and pain, and hamonizing actions of various medicines. The goal of this systematic review, which includes meta-analysis and network pharmacology in preclinical studies, is to investigate the ...
DOI:
10.1016/j.jep.2022.115444

46. Predictive quality control for compound liquorice tablets by the intelligent mergence fingerprint method combined with the systematic quantitative fingerprint method

Author:
Zhifei Hou; Guoxiang Sun
Source:
Phytochemical analysis 2021 v.32 no.6 pp. 1118-1130
ISSN:
0958-0344
Subject:
anise; camphor; licorice; models; oils; phytochemicals; prediction; quality control; sodium benzoate; China
Abstract:
... INTRODUCTION: Compound liquorice tablet (CLT) is a herbal compound preparation and is used as a classic antitussive and expectorant in China. It is composed of liquorice extract powder, opioid powder, star anise oil, camphor, and sodium benzoate. The complexity of herbal materials brings a huge challenge in producing compound preparations with stable and uniform quality consistency. OBJECTIVE: To ...
DOI:
10.1002/pca.3053

47. Prenylated Phenolic Compounds from the Aerial Parts of Glycyrrhiza uralensis as PTP1B and α-Glucosidase Inhibitors

Author:
Jing-ran Fan; Yi Kuang; Ze-yuan Dong; Yang Yi; Yan-xia Zhou; Bin Li; Xue Qiao; Min Ye
Source:
Journal of natural products 2020 v.83 no.4 pp. 814-824
ISSN:
1520-6025
Subject:
Glycyrrhiza uralensis; aerial parts; alpha-glucosidase; blood glucose; blood serum; enzyme inhibitors; ethanol; glucose; glycemic effect; herbal medicines; human cell lines; inhibitory concentration 50; insulin; insulin resistance; isoflavans; licorice; medicinal plants; mice; models; nuclear magnetic resonance spectroscopy; phenolic compounds; rhizomes; roots; spectral analysis
Abstract:
... Glycyrrhiza uralensis (liquorice) is a well-known medicinal plant. Its roots and rhizomes are used as the popular Chinese herbal medicine Gan-Cao. An ethanol extract of the aerial parts of G. uralensis showed antidiabetic effects on db/db mice. It decreased the blood glucose level by 30.3% and increased the serum insulin level by 41.8% compared to the control group. Eighty-six phenolic compounds ( ...
DOI:
10.1021/acs.jnatprod.9b00262

48. Preparation, characterization, pharmacokinetics, and antirenal injury activity studies of Licochalcone A‐loaded liposomes

Author:
Jing Liu; Zhongan Zhu; Yuhang Yang; Michael Adu‐Frimpong; Lin Chen; Hao Ji; Elmurat Toreniyazov; Qilong Wang; Jiangnan Yu; Ximing Xu
Source:
Journal of food biochemistry 2022 v.46 no.1 pp. e14007
ISSN:
0145-8884
Subject:
Oriental traditional medicine; adenine; antioxidant activity; bioavailability; encapsulation; flavonoids; functional foods; intragastric administration; licorice; models; particle size; pharmacodynamics; pharmacokinetics; renal failure; therapeutics; tissue distribution; water solubility; zeta potential
Abstract:
... A liposome of Licochalcone A (LCA‐Liposomes) was purposively prepared to ameliorate the low in vivo availability and efficacy of LCA. Physical characterization of LCA‐Liposomes was carried out mainly by determining particle size, morphology, zeta potential (Z‐potential), and efficiency of LCA encapsulation (EE) via appropriate techniques. Also, the rate of LCA release in vitro and distribution in ...
DOI:
10.1111/jfbc.14007

49. Prevention of MEK-ERK-1/2 hyper-activation underlines the neuroprotective effect of Glycyrrhiza glabra L. (Yashtimadhu) against rotenone-induced cellular and molecular aberrations

Author:
Gayathree Karthikkeyan; Ravishankar Pervaje; Sameera Krishna Pervaje; Thottethodi Subrahmanya Keshava Prasad; Prashant Kumar Modi
Source:
Journal of ethnopharmacology 2021 v.274 pp. 114025
ISSN:
0378-8741
Subject:
Glycyrrhiza glabra; Parkinson disease; apoptosis; brain; cell cycle; cytochrome c; cytotoxicity; licorice; memory; mitochondria; models; neuroprotective effect; oxidative stress; pro-apoptotic proteins; rotenone; therapeutics; traditional medicine
Abstract:
... Yashtimadhu choorna (powder) is prepared from the dried root of Glycyrrhiza glabra L., commonly known as licorice. The Indian Ayurvedic system classifies Yashtimadhu as a Medhya Rasayana that can enhance brain function, improves memory, and possess neuroprotective functions, which can be used against neurodegenerative diseases like Parkinson's disease (PD). We aimed to decipher the neuroprotective ...
DOI:
10.1016/j.jep.2021.114025

50. Promoting effect of licorice extract on spermatogonial proliferation and spermatocytes differentiation of neonatal mice in vitro

Author:
Cheng Wang; Yuji Jin; Yingji Jin
Source:
In vitro cellular & developmental biology 2016 v.52 no.2 pp. 149-155
ISSN:
1071-2690
Subject:
Glycyrrhiza uralensis; antibodies; herbal medicines; immunohistochemistry; in vitro studies; licorice; male fertility; mice; models; neonates; organ culture; proliferating cell nuclear antigen; quantitative analysis; recombinant proteins; spermatocytes; spermatogenesis; spermatogonia; staining; synaptonemal complex; testes
Abstract:
... Licorice (glycyrrhiza uralensis) is known as an herb with detoxication, and it has been widely used in clinical prescription of Oriental herbal medicine. Studies on the effects of licorice in the reproductive system were very rare, especially in spermatogenesis. In order to elucidate the effects of licorice on spermatogonial proliferation and spermatocyte differentiation during neonatal mice sperm ...
DOI:
10.1007/s11626-015-9966-z