Subject: reactive oxygen species and Western blotting

1. 6-methoxydihydroavicine, the alkaloid extracted from Macleaya cordata (Willd.) R. Br. (Papaveraceae), triggers RIPK1/Caspase-dependent cell death in pancreatic cancer cells through the disruption of oxaloacetic acid metabolism and accumulation of reactive oxygen species

Author:: Nengfang Ma; Fugen Shangguan; Hongfei Zhou; Huimin Huang; Jun Lei; Jing An; Guihua Jin; Weiwei Zhuang; Shipeng Zhou; Shijia Wu; Hongping Xia; Hailong Yang; Linhua Lan
Source:: Phytomedicine 2022 v.102 pp. 154164
ISSN:: 0944-7113
Subject:: Macleaya cordata; Western blotting; alkaloids; apoptosis; caspases; cell growth; energy metabolism; flow cytometry; glycolysis; homeostasis; mitochondria; mitophagy; neoplasm cells; oxaloacetic acid; pancreatic neoplasms; reactive oxygen species
Abstract:: ... Many extracts and purified alkaloids of M. cordata (Papaveraceae family) have been reported to display promising anti-tumor effects by inhibiting cancer cell growth and inducing apoptosis in many cancer types. However, no evidence currently exists for anti-pancreatic cancer activity of alkaloids extracted from M. cordata, including a novel alkaloid named 6‑methoxy dihydrosphingosine (6-Methoxydihy ...
DOI:: 10.1016/j.phymed.2022.154164
: https://doi.org/10.1016/j.phymed.2022.154164

2. Activation of mitochondrial-associated apoptosis signaling pathway and inhibition of PI3K/Akt/mTOR signaling pathway by voacamine suppress breast cancer progression

Author:: Yi Zuo; Chao-zheng Zhang; Qing Ren; Yao Chen; Xiao Li; Ji-rui Yang; Hong-xiang Li; Wen-tao Tang; Hing-Man HO; Chen Sun; Mei-mei Li; Bo Ren; Yun Deng; Mao-lin Wang; Jun Lu
Source:: Phytomedicine 2022 v.99 pp. 154015
ISSN:: 0944-7113
Subject:: Voacanga africana; Western blotting; alkaloids; apoptosis; breast neoplasms; cell proliferation; cyclin-dependent kinase; cyclins; flow cytometry; humans; interphase; membrane potential; mice; mitochondrial membrane; morbidity; mortality; neoplasm cells; neoplasm progression; protein synthesis; reactive oxygen species; toxicity
Abstract:: ... Breast cancer is one of the malignant tumors with the highest morbidity and mortality rate. Numerous efficient anti-breast cancer drugs are being derived from the development of natural products. Voacamine (VOA), a bisindole alkaloid isolated from Voacanga africana Stapf, possesses various pharmacological and biological activities. In this study, we investigated the efficacy of VOA against breast ...
DOI:: 10.1016/j.phymed.2022.154015
: https://doi.org/10.1016/j.phymed.2022.154015

3. Anemoside B4 prevents chronic obstructive pulmonary disease through alleviating cigarette smoke-induced inflammatory response and airway epithelial hyperplasia

Author:: Huimiao Ma; Ziye Zhou; Lanying Chen; Lingling Wang; Qi Muge
Source:: Phytomedicine 2022 v.107 pp. 154431
ISSN:: 0944-7113
Subject:: Anemone chinensis; Western blotting; catalase; cell viability; cigarettes; epithelium; glutathione peroxidase; humans; hyperplasia; inflammation; ingredients; interleukin-8; lung function; lung neoplasms; lungs; malondialdehyde; medicinal plants; mice; models; oxidative stress; protein synthesis; proteinases; reactive oxygen species; risk; smoke; stress response; superoxide dismutase; therapeutics
Abstract:: ... Cigarette smoke (CS) is one of the major risk factors for chronic obstructive pulmonary disease (COPD) and increases the risk of lung cancer (LC). Anemoside B4 (B4) is the main bioactive ingredient in Pulsatilla chinensis (P. chinensis), a traditional medicinal herb for various diseases. It has a wide range of anti-inflammatory, anti-oxidation and anti-cancer activities. However, in recent years, ...
DOI:: 10.1016/j.phymed.2022.154431
: https://doi.org/10.1016/j.phymed.2022.154431

4. Antagonistic Effect of Selenium on Fumonisin B1 Promotes Neutrophil Extracellular Traps Formation in Chicken Neutrophils

Author:: Huquan Zhu; Qinfang Yu; Huimin Ouyang; Ruofan Zhang; Jinhong Li; Runxi Xian; Kai Wang; Xinran Li; Changyu Cao
Source:: Journal of agricultural and food chemistry 2022 v.70 no.19 pp. 5911-5920
ISSN:: 1520-5118
Subject:: DNA; Western blotting; chickens; drugs; elastase; fluorescence; fluorescence microscopy; food chemistry; fumonisin B1; gene expression; genes; glutathione peroxidase; histones; innate immunity; mechanism of action; neutrophils; protein synthesis; quantitative polymerase chain reaction; reactive oxygen species; selenoproteins; thioredoxins; toxicity
Abstract:: ... Neutrophils are an important component of the innate immune system, and one of their defense mechanisms, neutrophil extracellular traps (NETs), is a hot topic of the current research. This study explored the effects of fumonisin B1 (FB1) on chicken neutrophil production of NETs and its possible molecular mechanism of action. Scanning electron microscopy and fluorescence microscopy were used to obs ...
DOI:: 10.1021/acs.jafc.2c01329
: https://doi.org/10.1021/acs.jafc.2c01329

5. Black cardamom (Amomum subulatum Roxb.) fruit extracts exhibit apoptotic activity against lung cancer cells

Author:: Pooja Makhija; Harish K. Handral; Gomathi Mahadevan; Himanshu Kathuria; Gautam Sethi; Bert Grobben
Source:: Journal of ethnopharmacology 2022 v.287 pp. 114953
ISSN:: 0378-8741
Subject:: Amomum subulatum; DNA; DNA damage; Western blotting; apoptosis; cardamom; cell cycle; cough; cytotoxicity; fruits; indigenous knowledge; lung neoplasms; lungs; methylene chloride; reactive oxygen species; toxicity testing; traditional medicine; tuberculosis
Abstract:: ... The dried fruits of Amomum subulatum Roxb. (A. subulatum) are widely used as a spice. It is a part of official ayurvedic formulations used in folklore medicine to treat cancer.A. subulatum has been used in ayurvedic formulations to treat various lung conditions such as cough, lung congestion, pulmonary tuberculosis. The present traditional knowledge highlights the effectiveness of A. subulatum in ...
DOI:: 10.1016/j.jep.2021.114953
: https://doi.org/10.1016/j.jep.2021.114953

6. Cedrus libani tar prompts reactive oxygen species toxicity and DNA damage in colon cancer cells

Author:: Ebru Temiz; Kadir Eği; Ismail Koyuncu; Ozgür Yüksekdag; Yusuf Kurt; Murat Tiken; Sükrü Akmese
Source:: Molecular biology reports 2022 v.49 no.8 pp. 7939-7952
ISSN:: 0301-4851
Subject:: Cedrus libani; DNA damage; Western blotting; antineoplastic activity; apoptosis; butyric acid; cancer therapy; caspase-8; colorectal neoplasms; coumarin; cytotoxicity; drug therapy; flow cytometry; metabolites; molecular biology; neoplasm cells; p-coumaric acid; propionic acid; reactive oxygen species; vanillic acid; viability
Abstract:: ... BACKGROUND: Many chemotherapeutic drugs used in cancer treatment have anticancer properties by inducing reactive oxygen species (ROS). However, the same effect occurs in normal cells, limiting the availability of these drugs. Therefore, studies on the detection of new herbal anticancer agents that have selective effects on cancer cells are of great importance. The aim of this study is to investiga ...
DOI:: 10.1007/s11033-022-07631-7
: https://doi.org/10.1007/s11033-022-07631-7

7. Clarifying winter clean heating importance: Insight chemical compositions and cytotoxicity exposure to primary and aged pollution emissions in China rural areas

Author:: Jian Sun; Xinyi Niu; Bin Zhang; Leiming Zhang; Jinjin Yu; Kun He; Tian Zhang; Qiyuan Wang; Hongmei Xu; Junji Cao; Zhenxing Shen
Source:: Journal of environmental management 2022 v.320 pp. 115822
ISSN:: 0301-4797
Subject:: Western blotting; aerosols; cytotoxicity; environmental management; fuel combustion; photochemistry; pollution; reactive oxygen species; water solubility; China
Abstract:: ... Residential solid fuel combustion (RSFC) is an important source of PM₂.₅. Here we investigate the cytotoxicity of primarily emitted and photochemically aged PM₂.₅ to A549 cells. Owing to the formation of water-soluble ions and organics (e.g., oPAHs and nPAHs), emission factors of PM₂.₅ were increased by 44.4% on average after 7-day equivalent photochemical aging, which greatly altered chemical pro ...
DOI:: 10.1016/j.jenvman.2022.115822
: https://doi.org/10.1016/j.jenvman.2022.115822

8. Compound Tongluo Decoction inhibits endoplasmic reticulum stress-induced ferroptosis and promoted angiogenesis by activating the Sonic Hedgehog pathway in cerebral infarction

Author:: Zhen Hui; Sulei Wang; Jianxiang Li; Jingqing Wang; Zhennian Zhang
Source:: Journal of ethnopharmacology 2022 v.283 pp. 114634
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Western blotting; angiogenesis; animal models; antagonists; brain; butyric acid; endoplasmic reticulum; endoplasmic reticulum stress; ferroptosis; fluorescent antibody technique; immunohistochemistry; infarction; malondialdehyde; reactive oxygen species; superoxide dismutase
Abstract:: ... Cerebral infarction is one of the most common types of cerebrovascular diseases that threaten people's health. Compound Tongluo Decoction (CTLD), a traditional Chinese medicine formula, has various pharmacological activities, including the alleviation of cerebral infarction symptoms.Aim of the study: This study aims to explore the potential mechanism by which CTLD alleviates cerebral infarction.Mi ...
DOI:: 10.1016/j.jep.2021.114634
: https://doi.org/10.1016/j.jep.2021.114634

9. Dengzhan Xixin injection derived from a traditional Chinese herb Erigeron breviscapus ameliorates cerebral ischemia/reperfusion injury in rats via modulation of mitophagy and mitochondrial apoptosis

Author:: Lu Yang; Yiwen Tao; Liuling Luo; Yi Zhang; Xiaobo Wang; Xianli Meng
Source:: Journal of ethnopharmacology 2022 v.288 pp. 114988
ISSN:: 0378-8741
Subject:: Erigeron breviscapus; Oriental traditional medicine; Western blotting; adenosine triphosphate; animal models; apoptosis; blood flow; brain; caffeic acid; caspase-3; complications (disease); fluorescent antibody technique; high performance liquid chromatography; infarction; ischemia; lysosomes; malondialdehyde; membrane potential; mitochondria; mitochondrial DNA; mitochondrial membrane; mitophagy; neurons; protein synthesis; quantitative polymerase chain reaction; reactive oxygen species; reperfusion injury; superoxide dismutase; therapeutics; transmission electron microscopy; ultrastructure; China
Abstract:: ... Dengzhan Xixin injection (DX), a preparation of extracts from traditional Chinese medicine Erigeron breviscapus (Vaniot) Hand.-Mazz., has been widely used in clinical treatment of cerebral ischemia sequelae in China for a long history. However, its underlying mechanisms remain unclear. The objective of this present study aimed to investigate the therapeutic effects of DX on cerebral ischemia/reper ...
DOI:: 10.1016/j.jep.2022.114988
: https://doi.org/10.1016/j.jep.2022.114988

10. Development of a sandwich ELISA for the detection of chicken colony-stimulating factor 1

Author:: Alfredo Panebra; Hyun S. Lillehoj
Source:: Poultry science 2022 v.101 no.7 pp. 101924
ISSN:: 0032-5791
Subject:: Eimeria acervulina; Escherichia coli; Western blotting; applied research; blood serum; bone metabolism; cell lines; chemotaxis; chickens; enzyme-linked immunosorbent assay; fluorescent labeling; homeostasis; macrophages; mice; neutralization; nitric oxide; phagocytosis; pregnancy; reactive oxygen species
Abstract:: ... Macrophage colony-stimulating factor-1 (M-CSF-1 or CSF-1) is a hematopoietic growth factor that stimulates the survival, proliferation, and differentiation of the mononuclear phagocyte lineage and is involved in bone metabolism, fertility, pregnancy, inflammatory processes, and homeostasis. CSF-1-activated macrophages display unique features, such as distinguishable cell surface antigens, enhanced ...
DOI:: 10.1016/j.psj.2022.101924
CHORUS:: 10.1016/j.psj.2022.101924
: https://doi.org/10.1016/j.psj.2022.101924

11. Di-(2-Ethylhexyl) Phthalate and Microplastics Induced Neuronal Apoptosis through the PI3K/AKT Pathway and Mitochondrial Dysfunction

Author:: Wenyue Zhang; Xinyue Sun; Xue Qi; Xiaojing Liu; Yilei Zhang; Senqiu Qiao; Hongjin Lin
Source:: Journal of agricultural and food chemistry 2022 v.70 no.35 pp. 10771-10781
ISSN:: 1520-5118
Subject:: Western blotting; acridine orange; apoptosis; cerebrum; eosin; ethidium; flow cytometry; food chemistry; gene expression; mechanism of action; microplastics; mitochondria; neurons; neurotoxicity; phthalates; protein synthesis; reactive oxygen species; transmission electron microscopy
Abstract:: ... Di-(2-Ethylhexyl) phthalate (DEHP) and microplastics (MPs) have released widespread residues to the environment and possess the ability to cause damage to humans and animals. However, there are still gaps in the study of damage to neurons caused by DEHP and MPs in mice cerebra and whether they have combined toxic effects. To investigate the underlying mechanism of action, mice were fed 200 mg/kg D ...
DOI:: 10.1021/acs.jafc.2c05474
: https://doi.org/10.1021/acs.jafc.2c05474

12. Dihydroquercetin suppresses cigarette smoke induced ferroptosis in the pathogenesis of chronic obstructive pulmonary disease by activating Nrf2-mediated pathway

Author:: Xiangming Liu; Yiming Ma; Lijuan Luo; Dandan Zong; Herui Li; Zihang Zeng; Yanan Cui; Weiwei Meng; Yan Chen
Source:: Phytomedicine 2022 v.96 pp. 153894
ISSN:: 0944-7113
Subject:: Western blotting; cell viability; cigarettes; ferroptosis; intraperitoneal injection; lipid peroxidation; lipids; malondialdehyde; mice; mitochondria; pathogenesis; phospholipid-hydroperoxide glutathione peroxidase; protective effect; protein synthesis; reactive oxygen species; respiratory tract diseases; smoke; solutes; superoxide dismutase; taxifolin; transmission electron microscopy
Abstract:: ... Dihydroquercetin (DHQ) is a flavonoid with strong anti-inflammatory and antioxidant effects. However, its protective activity against cigarette smoke-induced ferroptosis in the pathogenesis of chronic obstructive pulmonary disease and its underlying mechanisms remain unclear.The present study was conducted to investigate the protective role of DHQ in the pathogenesis of COPD in vivo and in vitro.A ...
DOI:: 10.1016/j.phymed.2021.153894
: https://doi.org/10.1016/j.phymed.2021.153894

13. Ephedrae Herba polysaccharides inhibit the inflammation of ovalbumin induced asthma by regulating Th1/Th2 and Th17/Treg cell immune imbalance

Author:: Beibei Zhang; Mengnan Zeng; Qinqin Zhang; Ru Wang; Jufang Jia; Bing Cao; Meng Liu; Pengli Guo; Yuhan Zhang; Xiaoke Zheng; Weisheng Feng
Source:: Molecular immunology 2022 pp. -
ISSN:: 0161-5890
Subject:: CD4-positive T-lymphocytes; Western blotting; apoptosis; asthma; blood serum; cough; dendritic cells; dexamethasone; enzyme-linked immunosorbent assay; eosin; flow cytometry; immunoglobulin E; immunohistochemistry; inflammation; interleukin-10; interleukin-13; interleukin-17; interleukin-4; interleukin-6; lungs; macrophages; models; natural killer cells; neutrophils; ovalbumin; oxidative stress; polysaccharides; reactive oxygen species; reverse transcription; spleen; tumor necrosis factors
Abstract:: ... This study aimed to investigate the anti-asthma effects of Ephedrae Herba polysaccharides (PE) and possible mechanisms related to immune inflammatory response. An asthma model was established in rats using ovalbumin (OVA). Seventy rats were randomly assigned to five groups: control, model, dexamethasone (DEX, 0.075mg/kg), low dose polysaccharides (LPE, 137.71mg/kg) and high dose polysaccharides (H ...
DOI:: 10.1016/j.molimm.2022.09.009
: https://doi.org/10.1016/j.molimm.2022.09.009

14. Exploring the protective mechanism of baicalin in treatment of atherosclerosis using endothelial cells deregulation model and network pharmacology

Author:: Mingshuang Li; Conglin Ren
Source:: BMC complementary medicine and therapies 2022 v.22 no.1 pp. 257
ISSN:: 2662-7671
Subject:: Western blotting; algorithms; alternative medicine; atherosclerosis; baicalin; bioactive properties; data collection; flow cytometry; humans; lipopolysaccharides; microarray technology; models; oxidative stress; pharmacology; reactive oxygen species
Abstract:: ... BACKGROUND: Baicalin is a generally available flavonoid with potent biological activity. The present study aimed to assess the underlying mechanism of baicalin in treatment of atherosclerosis (AS) with the help of network pharmacology, molecular docking and experimental validation. METHODS: The target genes of baicalin and AS were identified from public databases, and the overlapping results were ...
DOI:: 10.1186/s12906-022-03738-3
: https://doi.org/10.1186/s12906-022-03738-3

15. Exposure to imidacloprid induce oxidative stress, mitochondrial dysfunction, inflammation, apoptosis and mitophagy via NF-kappaB/JNK pathway in grass carp hepatocytes

Author:: Zhiruo Miao; Zhiying Miao; Shengchen Wang; Hao Wu; Shiwen Xu
Source:: Fish & shellfish immunology 2022 v.120 pp. 674-685
ISSN:: 1050-4648
Subject:: Ctenopharyngodon idella; Western blotting; acetylcysteine; agricultural productivity; apoptosis; aspartic acid; caspase-9; fish; genes; hepatocytes; imidacloprid; inflammation; interleukin-6; membrane potential; mitochondria; mitochondrial membrane; mitophagy; oxidative stress; reactive oxygen species; shellfish; surface water; transcription factor NF-kappa B; water pollution
Abstract:: ... Imidacloprid (IMI) is a neonicotinoid compound widely used in agriculture production, causing surface water pollution and threatening non-target organisms. The aim of this study was to analyze the effects of IMI on grass carp (Ctenopharyngodon idellus) liver cell (L8824) injury. The L8824 cells were exposed to different doses of IMI (65 mg/L, 130 mg/L and 260 mg/L) for 24 h. Our results demonstrat ...
DOI:: 10.1016/j.fsi.2021.12.017
: https://doi.org/10.1016/j.fsi.2021.12.017

16. Fucosterol Isolated from Dietary Brown Alga Sargassum horneri Protects TNF-α/IFN-γ-Stimulated Human Dermal Fibroblasts Via Regulating Nrf2/HO-1 and NF-κB/MAPK Pathways

Author:: Kirinde Gedara Isuru Sandanuwan Kirindage; Arachchige Maheshika Kumari Jayasinghe; Eui-Jeong Han; Youngheun Jee; Hyun-Jin Kim; Sun Gil Do; Ilekuttige Priyan Shanura Fernando; Ginnae Ahn
Source:: Antioxidants 2022 v.11 no.8 pp. -
ISSN:: 2076-3921
Subject:: Japan; Sargassum horneri; Western blotting; dose response; ethanol; fibroblasts; heme oxygenase (biliverdin-producing); high performance liquid chromatography; humans; immunocytochemistry; inflammation; mechanism of action; metalloproteinases; mitogen-activated protein kinase; nuclear magnetic resonance spectroscopy; oxidative stress; phosphorylation; reactive oxygen species; secondary metabolites; tumor necrosis factors; viability; China; Korean Peninsula
Abstract:: ... Sargassum horneri is a well-known edible brown alga that is widely abundant in the sea near China, Korea, and Japan and has a wide range of bioactive compounds. Fucosterol (FST), which is a renowned secondary metabolite in brown algae, was extracted from S. horneri to 70% ethanol, isolated via high-performance liquid chromatography (HPLC), followed by the immiscible liquid-liquid separation, and i ...
DOI:: 10.3390/antiox11081429
: https://doi.org/10.3390/antiox11081429

17. Germacranolide- and guaianolide-type sesquiterpenoids from Achillea alpina L. reduce insulin resistance in palmitic acid-treated HepG2 cells via inhibition of the NLRP3 inflammasome pathway

Author:: Gui-Min Xue; Chen-Guang Zhao; Jin-Feng Xue; Kun Du; Jiang-Jing Duan; Hao Pan; Meng Li; Hui Chen; Yan-Jun Sun; Wei-Sheng Feng; Ting Ma; Wen-Da Zhang
Source:: Phytochemistry 2022 v.202 pp. 113297
ISSN:: 0031-9422
Subject:: Achillea; Western blotting; aerial parts; caspase-1; circular dichroism spectroscopy; crystal structure; glucose; insulin resistance; palmitic acid; plant biochemistry; reactive oxygen species; sesquiterpenoids; spectral analysis
Abstract:: ... Chemical investigation on the aerial part of Achillea alpina L. led to the isolation of twenty sesquiterpenoids. The structures of the undescribed achigermalides A–H were determined by extensive spectroscopic analysis, including NMR, HRESIMS, UV and IR, and their absolute configurations were established by computational electronic circular dichroism (ECD) method. The X-ray crystal structure for 8α ...
DOI:: 10.1016/j.phytochem.2022.113297
: https://doi.org/10.1016/j.phytochem.2022.113297

18. Ginsenoside-Rb1 prevents bone cartilage destruction through down-regulation of p-Akt, p-P38, and p-P65 signaling in rabbit

Author:: Mohammad Amjad Hossain; Md Jahangir Alam; Bumseok Kim; Chang-Won Kang; Jong-Hoon Kim
Source:: Phytomedicine 2022 v.100 pp. 154039
ISSN:: 0944-7113
Subject:: Panax; Western blotting; apoptosis; cartilage; caspase-3; collagen; disease models; dose response; femur; flow cytometry; glycosaminoglycans; histopathology; immunohistochemistry; metalloproteinases; osteoarthritis; pain; pathogenesis; plant products; protective effect; quality of life; rabbits; reactive oxygen species
Abstract:: ... Osteoarthritis (OA) is the most common joint complaint resulting in pain, disability, and loss of quality of life. On the other hand, ginsenoside-Rb1 is a plant product derived from ginseng that possesses immune-regulation and anti-inflammatory activities. However, it has been reported that different rout of administration but hydrogel-based Ginsenoside-Rb1 in an OA rabbit model has not been inves ...
DOI:: 10.1016/j.phymed.2022.154039
: https://doi.org/10.1016/j.phymed.2022.154039

19. Glucagon-like peptide-1 receptor activation by liraglutide promotes breast cancer through NOX4/ROS/VEGF pathway

Author:: Zhan-zhao Liu; Xian-xian Duan; Meng-ci Yuan; Jing Yu; Xiao Hu; Xiao Han; Lan Lan; Bo-wei Liu; Yue Wang; Jun-fang Qin
Source:: Life sciences 2022 v.294 pp. 120370
ISSN:: 0024-3205
Subject:: NAD(P)H oxidase (H2O2-forming); Western blotting; adenosine triphosphate; breast neoplasms; cell proliferation; diabetes; flow cytometry; glucagon-like peptide 1; humans; immunohistochemistry; mice; phenotype; quantitative polymerase chain reaction; reactive oxygen species; risk; signal transduction; toxicology; vascular endothelial growth factors
Abstract:: ... Scientific evidence imply the strong correlation between diabetes and breast cancer. Glucagon-like peptide-1 (GLP-1) and its analogue liraglutide, have been widely used for diabetes treatment. However, the role of GLP-1 receptor (GLP-1R) in breast cancer requires further elucidation. This study aimed to investigate the risk and the molecular mechanisms of liraglutide using in breast cancer. Quanti ...
DOI:: 10.1016/j.lfs.2022.120370
: https://doi.org/10.1016/j.lfs.2022.120370

20. Hemp Seed Fermented by Aspergillus oryzae Attenuates Lipopolysaccharide-Stimulated Inflammatory Responses in N9 Microglial Cells

Author:: Zeyuan Wang; Lehao Wu; Dongmei Fu; Yan Zhang; Chunzhi Zhang
Source:: Foods 2022 v.11 no.12 pp. -
ISSN:: 2304-8158
Subject:: Aspergillus oryzae; Western blotting; cytokines; fermentation; hemp; inducible nitric oxide synthase; lipopolysaccharides; mitogen-activated protein kinase; models; nitric oxide; oxidation; phosphatidylinositol 3-kinase; phosphorylation; reactive oxygen species
Abstract:: ... The objective of our present work was to explore the possible enhanced anti-neuroinflammatory ability of Aspergillus oryzae fermented hemp seed in lipopolysaccharide (LPS)-stimulated N9 microglial cells and elucidate its underlying mechanism. The water extract of hemp seed was fermented by Aspergillus oryzae. LPS-stimulated N9 microglial cells were employed for the inflammatory cell model. The rel ...
DOI:: 10.3390/foods11121689
: https://doi.org/10.3390/foods11121689

21. Hibiscus sabdariffa Extract Protects HaCaT Cells against Phenanthrene-Induced Toxicity through the Regulation of Constitutive Androstane Receptor/Pregnane X Receptor Pathway

Author:: Dicson Sheeja Malar; Mani Iyer Prasanth; Kanika Verma; Anchalee Prasansuklab; Tewin Tencomnao
Source:: Nutrients 2022 v.14 no.18 pp. -
ISSN:: 2072-6643
Subject:: Hibiscus sabdariffa; Western blotting; androstanes; antioxidant activity; cardiotoxicity; cell viability; cytotoxicity; ethanol; gene expression; gluconeogenesis; humans; keratinocytes; membrane potential; mitochondrial membrane; phenanthrenes; pregnanes; protective effect; reactive oxygen species; transcription (genetics)
Abstract:: ... Phenanthrene (Phe) exposure is associated with skin ageing, cardiotoxicity and developmental defects. Here, we investigated the mode of Phe toxicity in human keratinocytes (HaCaT cells) and the attenuation of toxicity on pre-treatment (6 h) with ethanol extract of Hibiscus sabdariffa calyxes (HS). Cell viability, reactive oxygen species (ROS) generation, mitochondrial membrane potential (ΔΨm) alte ...
DOI:: 10.3390/nu14183829
: https://doi.org/10.3390/nu14183829

22. Hydroxyproline alleviates 4-hydroxy-2-nonenal-induced DNA damage and apoptosis in porcine intestinal epithelial cells

Author:: Yun Ji; Yu He; Ying Yang; Zhaolai Dai; Zhenlong Wu
Source:: Animal nutrition 2022 v.9 pp. 7-15
ISSN:: 2405-6545
Subject:: DNA damage; Western blotting; animal nutrition; apoptosis; comet assay; epithelial cells; flow cytometry; fluorescent antibody technique; glutathione; histones; hydroxyproline; imino acids; intestinal mucosa; mitogen-activated protein kinase; oxidative stress; phosphorylation; quantitative polymerase chain reaction; reactive oxygen species; reverse transcription; sow milk; swine
Abstract:: ... Oxidative stress has been confirmed in relation to intestinal mucosa damage and multiple bowel diseases. Hydroxyproline (Hyp) is an imino acid abundant in sow's milk. Compelling evidence has been gathered showing the potential antioxidative properties of Hyp. However, the role and mechanism of Hyp in porcine intestinal epithelial cells in response to oxidative stress remains unknown. In this study ...
DOI:: 10.1016/j.aninu.2021.08.003
: https://doi.org/10.1016/j.aninu.2021.08.003

23. Identification of mitochondria-related hub genes in sarcopenia and functional regulation of MFG-E8 on ROS-mediated mitochondrial dysfunction and cell cycle arrest

Author:: He Li; Kaifang Guan; DanDan Liu; Min Liu
Source:: Food & function 2022 v.13 no.2 pp. 624-638
ISSN:: 2042-650X
Subject:: Parkinson disease; Western blotting; bioinformatics; brain; cell cycle checkpoints; cell proliferation; cell viability; cognition; cyclin-dependent kinase; cyclins; elderly; epidermal growth factor; fatty liver; gene expression; gene expression regulation; gene ontology; membrane glycoproteins; milk fat; mitochondria; myoblasts; oxidative phosphorylation; oxidative stress; protective effect; protein-protein interactions; reactive oxygen species; sarcopenia
Abstract:: ... Sarcopenia has high prevalence in the elderly population, but the genes and pathways related to aging in elderly patients with sarcopenia are poorly understood. Milk fat globule epidermal growth factor 8 (MFG-E8) is a peripheral membrane glycoprotein isolated from the milk fat globule membrane (MFGM). It has been found to exhibit various nutritional effects, including antibacterial, anti-cancer, a ...
DOI:: 10.1039/d1fo02610k
: https://doi.org/10.1039/d1fo02610k

24. Identification of the NADPH Oxidase (Nox) Subtype and the Source of Superoxide Production in the Micturition Centre

Author:: Qin Wu; Ayse Gurpinar; Maxwell Roberts; Patrizia Camelliti; Michael R. Ruggieri; Changhao Wu
Source:: Biology 2022 v.11 no.2 pp. -
ISSN:: 2079-7737
Subject:: NAD(P)H oxidase (H2O2-forming); Western blotting; aorta; bladder; brain; chemiluminescence; reactive oxygen species
Abstract:: ... Oxidative inflammatory damage to specialised brain centres may lead to dysfunction of their associated peripheral organs, such as the bladder. However, the source of reactive oxygen species (ROS) in specific brain regions that regulate bladder function is poorly understood. Of all ROS-generating enzymes, the NADPH oxidase (Nox) family produces ROS as its sole function and offers an advantage over ...
DOI:: 10.3390/biology11020183
: https://doi.org/10.3390/biology11020183

25. Impact of the Plastein Reaction of Casein Hydrolysates in the Presence of Exogenous Amino Acids on Their Anti-Inflammatory Effect in the Lipopolysaccharide-Stimulated Macrophages

Author:: Yun-Jiao Shi; Xin-Huai Zhao
Source:: Foods 2022 v.11 no.2 pp. -
ISSN:: 2304-8158
Subject:: Western blotting; amino acids; anti-inflammatory activity; casein; dose response; fluorescent antibody technique; hydrolysis; inflammation; interleukin-10; interleukin-6; lactate dehydrogenase; lipopolysaccharides; macrophages; microRNA; phagocytosis; plasteins; protein synthesis; reactive oxygen species; secretion
Abstract:: ... In this study, papain-generated casein hydrolysates (CH) with a degree of hydrolysis of 13.7% were subjected to a papain-mediated plastein reaction in the absence or presence of one of the exogenous amino acids—Gly, Pro, and Hyp—to prepare four plastein modifiers, or mixed with one of three amino acids to prepare three mixtures. The assay results confirmed that the reaction reduced free NH₂ for th ...
DOI:: 10.3390/foods11020196
: https://doi.org/10.3390/foods11020196

26. Influence of aryl hydrocarbon receptor and sulfotransferase 1A1 on bisphenol AF-induced clastogenesis in human hepatoma cells

Author:: Zongying Yang; Hang Yu; Hongwei Tu; Zhihong Chen; Keqi Hu; Hansi Jia; Yungang Liu
Source:: Toxicology 2022 v.471 pp. 153175
ISSN:: 0300-483X
Subject:: DNA; Western blotting; aryl hydrocarbon receptors; fluorescent antibody technique; glutathione; hepatoma; humans; micronucleus tests; mutagens; reactive oxygen species; superoxide dismutase; toxicity
Abstract:: ... Bisphenol compounds (BPs) are ubiquitously existing pollutants. Recent evidence shows that they may be activated by human CYP1A1 for clastogenic effects; however, factors that influence/mediate CYP1A1-activated 4,4′-(hexafluoroisopropylidene)diphenol (BPAF) toxicity, particularly the aryl hydrocarbon receptor (AhR), sulfotransferase (SULT) 1A1 [known to conjugate 2,2-bis(4-hydroxyphenol)-propane ( ...
DOI:: 10.1016/j.tox.2022.153175
: https://doi.org/10.1016/j.tox.2022.153175

27. Investigation of nickel sulfate‐induced cytotoxicity and underlying toxicological mechanisms in human umbilical vein endothelial cells through oxidative stress, inflammation, apoptosis, and MAPK signaling pathways

Author:: Yanli Liu; Xia Gong; Juan Wang; Yongxiang Wang; Yong Zhang; Tao Li; Juan Yan; Min Zhou; Benzhong Zhang
Source:: Environmental toxicology 2022 v.37 no.8 pp. 2058-2071
ISSN:: 1520-4081
Subject:: Western blotting; apoptosis; cardiovascular system; caspase-3; cell growth; cell viability; cytotoxicity; dose response; ecotoxicology; flow cytometry; genes; glutathione; inflammation; interleukin-6; lipid peroxidation; malondialdehyde; nickel; oxidation; oxidative stress; quantitative polymerase chain reaction; reactive oxygen species; stress response; sulfates; superoxide dismutase
Abstract:: ... Growing evidence indicates that nickle and its compounds have adverse effects on the cardiovascular system. In this study, the cytotoxic insults caused by nickel sulfate (NiSO₄) in human umbilical vein endothelial cells (HUVECs) were explored by examining cell viability, oxidative stress, inflammation, apoptosis, and MAPK signaling pathway activity. Cultured HUVECs were treated with varying concen ...
DOI:: 10.1002/tox.23550
: https://doi.org/10.1002/tox.23550

28. Isobavachalcone disrupts mitochondrial respiration and induces cytotoxicity through ROS accumulation and Akt suppression

Author:: Lin Zhao; Yingli Yu; Li Li; Jiarui Wang; Jing Wang; Shijia Su; Jingyi Ding; Yue Zhang; Anhong Wang; Kun Zhou
Source:: Toxicon 2022 v.216 pp. 28-36
ISSN:: 0041-0101
Subject:: Western blotting; acetylcysteine; apoptosis; cell viability; cytotoxicity; flavonoids; flow cytometry; hepatotoxicity; mitochondria; oxidative stress; phosphorylation; reactive oxygen species; toxicity testing
Abstract:: ... Isobavachalcone (IBC) is one of the flavonoid components in Fructus Psoraleae, and has been found multiple pharmacological effects. However, the hepatotoxicity of IBC has been overlooked and not been carefully studied. We aim to find out the cytotoxicity of IBC on HepG2 cells, and explore the underlying mechanisms. HepG2 cells were treated with IBC for 24 h, then MTT assay and LDH assay were used ...
DOI:: 10.1016/j.toxicon.2022.06.018
: https://doi.org/10.1016/j.toxicon.2022.06.018

29. Lithium intoxication induced pyroptosis via ROS/NF‐κB/NLRP3 inflammasome regulatory networks in kidney of mice

Author:: Hongyuan Jing; Fuhan Wang; Xue‐jiao Gao
Source:: Environmental toxicology 2022 v.37 no.4 pp. 825-835
ISSN:: 1520-4081
Subject:: Western blotting; antioxidant activity; antioxidant enzymes; carbonates; catalase; ecotoxicology; glutathione peroxidase; histopathology; humans; immunohistochemistry; inflammasomes; inflammation; kidneys; lithium; necrosis; neoplasms; nephrotic syndrome; oligomerization; poisoning; pyroptosis; reactive oxygen species; superoxide dismutase
Abstract:: ... Humans and animals may be exposed to increasing contaminant lithium (Li) concentrations in the environment with the use and disposal of Li‐containing products. Meanwhile, Li plays a key role in the treatment of human mental disorders, while the excessive accumulation of Li salts in the body can cause renal damage and nephrotic syndrome. In this study, the mechanism of renal inflammatory reaction i ...
DOI:: 10.1002/tox.23446
: https://doi.org/10.1002/tox.23446

30. MEHP promotes liver fibrosis by down-regulating STAT5A in BRL-3A hepatocytes

Author:: Yuezhu Zhang; Ju Hui; Yan Xu; Yingying Ma; Zhe Sun; Meng Zhang; Lushuang Nie; Lin Ye
Source:: Chemosphere 2022 v.295 pp. 133925
ISSN:: 0045-6535
Subject:: Western blotting; endocrine-disrupting chemicals; fibrosis; flow cytometry; genes; glutathione peroxidase; hepatocytes; liver; liver cirrhosis; malondialdehyde; metabolism; phthalates; quantitative polymerase chain reaction; reactive oxygen species; transfection
Abstract:: ... As an environmental endocrine disruptor, mono-2-ethylhexyl phthalate (MEHP) can interfere with liver metabolism and lead to liver diseases. We aimed to investigate the role of MEHP in liver fibrosis and its molecular mechanism. BRL-3A hepatocytes were exposed to MEHP (0, 10, 50, 100 and 200 μM) for 24 h. STAT5A gene was overexpressed by lentivirus transfection. The reactive oxygen species (ROS) wa ...
DOI:: 10.1016/j.chemosphere.2022.133925
: https://doi.org/10.1016/j.chemosphere.2022.133925

31. Macrophage immunity promotion effect of polysaccharide LGP-1 from Guapian tea via PI3K/AKT and NF-κB signaling pathway

Author:: Zhi Wu; Dong Wang; Cai-Xia Liu; Xiao-Hui Wang; Yan Chen; Qing-Xi Wu; Jin-Song Zhang
Source:: Journal of functional foods 2022 v.89 pp. 104946
ISSN:: 1756-4646
Subject:: Western blotting; atomic force microscopy; bioactive compounds; fluorescence; high performance liquid chromatography; immunoassays; interleukin-6; ion exchange; macrophages; phagocytosis; phosphatidylinositol 3-kinase; polysaccharides; reactive oxygen species; tea
Abstract:: ... Functionalization and bestowing high values upon bioactive tea polysaccharides have been focused recently. For this purpose, the immune activation effect on RAW264.7 macrophages promoted by Lu’an Guapian polysaccharide (LGP-1, 2.35 × 10⁵ Da) was investigated firstly. LGP-1 was obtained and characterized via DEAE 52 ion exchange column, high performance liquid chromatography and atomic force micros ...
DOI:: 10.1016/j.jff.2022.104946
: https://doi.org/10.1016/j.jff.2022.104946

32. Mechanisms of RAW264.7 macrophages immunomodulation mediated by polysaccharide from mung bean skin based on RNA-seq analysis

Author:: Li Qin; Shuai Chen; Liuming Xie; Qiang Yu; Yi Chen; Mingyue Shen; Jianhua Xie
Source:: Food research international 2022 v.154 pp. 111017
ISSN:: 0963-9969
Subject:: Toll-like receptor 4; Western blotting; food research; gene expression regulation; immune response; immunomodulation; immunomodulators; macrophages; mitogen-activated protein kinase; mung beans; nitric oxide; phagocytosis; polysaccharides; reactive oxygen species; sequence analysis
Abstract:: ... In this study, the immunomodulation properties and the possible molecular mechanisms of mung bean skin polysaccharide (MBP) on RAW264.7 were investigated. The results showed that MBP could enhance the phagocytic activity, promote intracellular reactive oxygen species (ROS) production as well as the release of nitric oxide (NO) and cytokines in macrophages. The results of global screening of all tr ...
DOI:: 10.1016/j.foodres.2022.111017
: https://doi.org/10.1016/j.foodres.2022.111017

33. Melatonin attenuates MPP+-induced apoptosis via heat shock protein in a Parkinson's disease model

Author:: Yu Jin Jung; Hyunsu Choi; Eungseok Oh
Source:: Biochemical and biophysical research communications 2022 v.621 pp. 59-66
ISSN:: 0006-291X
Subject:: 4',6-diamidino-2-phenylindole; Parkinson disease; Western blotting; apoptosis; caspase-3; cell viability; disease models; dopamine; glutathione peroxidase; heat shock proteins; heat stress; inflammation; malondialdehyde; melatonin; neurons; oxidative stress; reactive oxygen species; research; retinoic acid; superoxide dismutase; therapeutics; toxicity; toxins
Abstract:: ... Heat shock proteins (HSPs) play an essential role as molecular chaperones to prevent abnormal protein aggregation and misfolding. Moreover, they protect dopamine neurons from oxidative stress, inflammation, and apoptosis, all well-known pathomechanisms of Parkinson's disease (PD). Melatonin is a potent antioxidant that has the beneficial ability to prevent neurodegenerative diseases like PD. We ai ...
DOI:: 10.1016/j.bbrc.2022.06.099
: https://doi.org/10.1016/j.bbrc.2022.06.099

34. Mitochondria-targeted triphenylphosphonium-based compounds inhibit FcεRI-dependent degranulation of mast cells by preventing mitochondrial dysfunction through Erk1/2

Author:: Anastasia N. Pavlyuchenkova; Roman A. Zinovkin; Ciara I. Makievskaya; Ivan I. Galkin; Maria A. Chelombitko
Source:: Life sciences 2022 v.288 pp. 120174
ISSN:: 0024-3205
Subject:: Western blotting; fluorescence microscopy; mast cells; membrane potential; mitochondria; phosphatidylinositol 3-kinase; phosphorylation; reactive oxygen species
Abstract:: ... FcεRI-dependent activation and degranulation of mast cells (MC) play an important role in allergic diseases. We have previously demonstrated that triphenylphosphonium (TPP)-based antioxidant SkQ1 inhibits mast cell degranulation, but the exact mechanism of this inhibition is still unknown. This study focused on investigating the influence of TPP-based compounds SkQ1 and C₁₂TPP on FcεRI-dependent m ...
DOI:: 10.1016/j.lfs.2021.120174
: https://doi.org/10.1016/j.lfs.2021.120174

35. Nutritional properties of Europen eel (Anguilla anguilla) bone peptide-calcium and its apoptosis effect on Caco-2 cells

Author:: Hui Teng; Yuewei Qian; Xiaoyun Fan; Hui Cao; Yuting Tian; Lei Chen
Source:: Food science and human wellness 2022 v.11 no.6 pp. 1482-1490
ISSN:: 2213-4530
Subject:: Anguilla anguilla; Western blotting; absorption; adenocarcinoma; apoptosis; autophagy; bioactive properties; calcium; eel; epithelium; humans; peptides; protein synthesis; reactive oxygen species
Abstract:: ... The present study aimed at making a rational usage for European eel bone by-products by preparing Europen eel bone peptide chelated calcium (EBPC-Ca). Nutritional properties and bioactivity of EBPC-Ca were evaluated. Results showed that nutritional properties of calcium ions will cause intra- and inter-molecular folding and aggregation of peptide to uniformly form EBPC-Ca chelate. The chelated com ...
DOI:: 10.1016/j.fshw.2022.06.005
: https://doi.org/10.1016/j.fshw.2022.06.005

36. Oleic acid alleviates LPS-induced acute kidney injury by restraining inflammation and oxidative stress via the Ras/MAPKs/PPAR-γ signaling pathway

Author:: Beibei Zhang; Mengnan Zeng; Yangyang Wang; Meng Li; Yuanyuan Wu; Ruiqi Xu; Qinqin Zhang; Jufang Jia; Yanjie Huang; Xiaoke Zheng; Weisheng Feng
Source:: Phytomedicine 2022 v.94 pp. 153818
ISSN:: 0944-7113
Subject:: Rehmannia glutinosa; Western blotting; acute kidney injury; apoptosis; blood serum; calcium; creatinine; flow cytometry; inflammation; kidneys; medicinal properties; metabolism; metabolomics; oleic acid; oxidative stress; phenylalanine; reactive oxygen species; renal function; sphingolipids; taurine; urea nitrogen
Abstract:: ... Rehmannia Glutinosa Libosch. is applied for the treatment of renal and inflammatory-related diseases, and oleic acid (OA) is a compound isolated from Rehmannia Glutinosa Libosch.. Unfortunately, the pharmacological activity of OA on LPS treated acute kidney injury (AKI) has not been investigated. The research is aiming to probe the activities of OA on LPS-induced AKI. Information of OA effect on A ...
DOI:: 10.1016/j.phymed.2021.153818
: https://doi.org/10.1016/j.phymed.2021.153818

37. Oridonin attenuates low shear stress-induced endothelial cell dysfunction and oxidative stress by activating the nuclear factor erythroid 2-related factor 2 pathway

Author:: Zhipeng Chen; Heqian Liu; Xiaoqi Zhao; Subinur Mamateli; Cheng Liu; Lei Wang; Jing Yu; Yutong Liu; Jing Cai; Tong Qiao
Source:: BMC complementary medicine and therapies 2022 v.22 no.1 pp. 180
ISSN:: 2662-7671
Subject:: Danio rerio; Western blotting; alternative medicine; atherosclerosis; chemometrics; disulfides; endothelial cells; endothelins; fluorescence microscopes; gene expression; glutathione; high fat diet; inflammation; lipids; malondialdehyde; models; neutrophils; nitric oxide; oxidative stress; prostaglandin synthase; protective effect; protein synthesis; reactive oxygen species; shear stress; superoxide dismutase; transfection
Abstract:: ... BACKGROUND: Atherosclerosis (AS) is the primary cause of cardiovascular disease and the incidence is extremely common; however, there are currently few drugs that can effectively treat AS. Although oridonin has been widely used to treat inflammation and cancer for numerous years, to the best of our knowledge, its protective effect against AS has not been reported. Therefore, the present study aime ...
DOI:: 10.1186/s12906-022-03658-2
: https://doi.org/10.1186/s12906-022-03658-2

38. Oxidative stress and apoptosis in Asian honey bees (A. cerana) exposed to multiple pesticides in intensive agricultural landscape

Author:: Debaditya Kumar; Durba Banerjee; Priyadarshini Chakrabarti; Sagartirtha Sarkar; Parthiba Basu
Source:: Apidologie 2022 v.53 no.2 pp. 25
ISSN:: 0044-8435
Subject:: DNA damage; Western blotting; agricultural landscapes; apoptosis; cognition; cytochrome c; honey; honey bees; intensive farming; mitochondria; oxidative stress; pesticide application; pesticides; pollinators; reactive oxygen species
Abstract:: ... Pesticide usage associated with intensive agriculture is implicated as a major factor for pollinator decline. Apart from developmental and physiological impairments, pesticide exposure has been shown to cause major cognitive anomalies in honey bees. However, there are gaps in our understanding about the physiological and molecular mechanism that causes the impairments. The present study evaluates ...
DOI:: 10.1007/s13592-022-00929-2
: https://doi.org/10.1007/s13592-022-00929-2

39. Perillyl alcohol attenuates rheumatoid arthritis via regulating TLR4/NF-κB and Keap1/Nrf2 signaling pathways: A comprehensive study onin-vitro and in-vivo experimental models

Author:: Eswara Rao Puppala; Siddhi Jain; Pritam Saha; Mahesh Rachamalla; Syamprasad NP; Sai Sudha Yalamarthi; Md. Abubakar; Antra Chaudhary; D Chamundeswari; Murty USN; Jagadeesh Kumar Gangasani; V.G.M. Naidu
Source:: Phytomedicine 2022 v.97 pp. 153926
ISSN:: 0944-7113
Subject:: Western blotting; X-radiation; alcohols; body weight; gene expression; geranylgeranyl diphosphate synthase; histology; histopathology; inflammation; interleukin-6; lipid peroxidation; macrophages; mice; monoterpenoids; nitrates; oxidative stress; protein synthesis; radiography; reactive oxygen species; rheumatoid arthritis
Abstract:: ... Rheumatoid arthritis is a chronic and idiopathic autoimmune disorder. Perillyl alcohol (POH) is a monoterpene which can be extracted from widely available essential oils and is known for its strong anti-inflammatory and anti-oxidant properties. Recent studies have been proven that inhibitors of farnesyltransferase enzyme showed significant anti-arthritic activity. POH is one such natural molecule ...
DOI:: 10.1016/j.phymed.2022.153926
: https://doi.org/10.1016/j.phymed.2022.153926

40. Polyphenols in Ilex latifolia Thunb. inhibit human lung cancer cell line A549 by regulation of the PI3K-Akt signaling pathway

Author:: Jing Chen; Yesheng Du; Yanyan Long; Dan Tao; Mengyu Hu; Yong Jiang; Yue Wan; Dingyi Yang
Source:: BMC complementary medicine and therapies 2022 v.22 no.1 pp. 85
ISSN:: 2662-7671
Subject:: B-lymphocytes; Ilex latifolia; Western blotting; alternative medicine; apoptosis; caspase-9; cell proliferation; epithelium; fluorescence; functional foods; gene expression; high performance liquid chromatography; humans; hypoxia-inducible factor 1; kaempferol; lactate dehydrogenase; lung neoplasms; lungs; neoplasm cells; non-specific serine/threonine protein kinase; phosphatidylinositol 3-kinase; polyphenols; prostaglandin synthase; protein synthesis; quantitative polymerase chain reaction; rapamycin; reactive oxygen species; rutin; tea; vascular endothelial growth factors
Abstract:: ... BACKGROUND: The leaves of the plant Ilex latifolia Thunb. can be made into Kuding tea, which is a drink rich in polyphenols. This study aimed to observe the effect of Ilex latifolia Thunb. polyphenols (ILTPs) on human lung cancer cell line A549 (A549 cells) by regulating the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway. METHODS: In vitro cultured cells were treated w ...
DOI:: 10.1186/s12906-022-03568-3
: https://doi.org/10.1186/s12906-022-03568-3

41. Pretreatment of hydroethanolic extract of Dillenia indica L. attenuates oleic acid induced NAFLD in HepG2 cells via modulating SIRT-1/p-LKB-1/AMPK, HMGCR & PPAR-α signaling pathways

Author:: M.S. Poornima; G. Sindhu; Abraham Billu; C.R. Sruthi; P. Nisha; Pinku Gogoi; Gakul Baishya; K. G Raghu
Source:: Journal of ethnopharmacology 2022 v.292 pp. 115237
ISSN:: 0378-8741
Subject:: Ayurvedic medicine; Dillenia indica; Western blotting; asthma; catechin; conservation areas; diabetes; epicatechin; fatty liver; fenofibrate; food plants; forests; indigestion; jaundice; kaempferol; leaves; lipogenesis; mitochondria; models; naringenin; oleic acid; pain; polyphenols; reactive oxygen species; rural communities; shikimic acid; syringic acid; vanillic acid; India
Abstract:: ... Dillenia indica L. is an edible plant from the Dilleniaceae family present in the forest of India and other Asian countries. Different parts of this plant are being used in the traditional system of medicines for various diseases like diabetes, indigestion, asthma, jaundice, and rheumatic pain by various rural communities. This plant is very common among Khamptis traditional healers, the rural com ...
DOI:: 10.1016/j.jep.2022.115237
: https://doi.org/10.1016/j.jep.2022.115237

42. Procalcitonin mediates vascular dysfunction in obesity

Author:: Laura Brabenec; Katharina E.M. Hellenthal; Melanie Müller; Sebastian Kintrup; Finnja Zurek-Leffers; Marina Kardell; Mandy Otto; Nana-Maria Wagner
Source:: Life sciences 2022 v.307 pp. 120889
ISSN:: 0024-3205
Subject:: Western blotting; adipose tissue; antagonists; calcitonin; calcitonin gene-related peptide; comorbidity; inflammation; intravenous injection; magnetism; mice; nitric oxide; obesity; reactive oxygen species; vasodilation
Abstract:: ... Obesity is accompanied by a chronic low-grade inflammation associated with endothelial dysfunction and vascular complications. Procalcitonin is a marker of inflammation, secreted by adipose tissue and elevated in obese subjects. We here investigated whether visceral or perivascular fat-derived procalcitonin is a target to improve obesity-induced endothelial dysfunction. Procalcitonin expression wa ...
DOI:: 10.1016/j.lfs.2022.120889
: https://doi.org/10.1016/j.lfs.2022.120889

43. Protein sulfenylation contributes to oxidative burst-triggered responses during the interaction between Botrytis cinerea and Nicotiana benthamiana

Author:: Ying Wang; Guangjin Li; Tong Chen; Shiping Tian
Source:: Journal of proteomics 2022 v.251 pp. 104423
ISSN:: 1874-3919
Subject:: Botrytis cinerea; DNA; Nicotiana benthamiana; Western blotting; cysteine; genes; host-pathogen relationships; mass spectrometry; oxygen; post-translational modification; proteomics; reactive oxygen species
Abstract:: ... Reactive oxygen species (ROS) play a crucial role as signaling molecules in plant responses to pathogen infection. It is highly reactive with cellular components such as DNA, lipids and proteins, thereby leading to serious oxidative damages. Cysteine residues are sensitive targets of ROS in a post-translational modification known as sulfenylation. However, during plant-pathogen interaction, it is ...
DOI:: 10.1016/j.jprot.2021.104423
: https://doi.org/10.1016/j.jprot.2021.104423

44. Quercetin-3-Rutinoside alleviates radiation-induced lung inflammation and fibrosis via regulation of NF-κB/TGF-β1 signaling

Author:: Savita Verma; Ajaswrata Dutta; Akshu Dahiya; Namita Kalra
Source:: Phytomedicine 2022 v.99 pp. 154004
ISSN:: 0944-7113
Subject:: DNA damage; Western blotting; actin; aquaporins; caspase-3; cell death; collagen; death; exposure scenario; fibrosis; gamma radiation; histopathology; immunohistochemistry; inflammation; intercellular adhesion molecule-1; interleukin-18; interleukin-6; irradiation; lungs; muscles; necrosis; neoplasms; nitric oxide; pathogenesis; pneumonia; radioprotective effect; radiotherapy; reactive oxygen species
Abstract:: ... Radiation exposure to lungs during nuclear catastrophes or radiotherapy poses long-term side effects and can induce pulmonary injury sufficient for causing death. The strategies for preventing or reversing radiation-induced lung injuries have not been yet developed. Quercetin-3-Rutinoside (Q-3-R), a polyphenolic bioflavonoid, has shown multifaceted pharmacological applications due to its high anti ...
DOI:: 10.1016/j.phymed.2022.154004
: https://doi.org/10.1016/j.phymed.2022.154004

45. Reactive oxygen species-dependent-NLRP3 inflammasome activation in human neutrophils induced by l-amino acid oxidase derived from Calloselasma rhodostoma venom

Author:: Mauro Valentino Paloschi; Charles Nunes Boeno; Jéssica Amaral Lopes; Cristina Matiele Alves Rego; Milena Daniela Souza Silva; Hallison Mota Santana; Suzanne Nery Serrath; Yoda Janaina Ikenohuchi; Braz Junior Campos Farias; Kátia Paula Felipin; Neriane Monteiro Nery; Valdison Pereira dos Reis; Caleb Torres de Lima Lemos; Jaina Rodrigues Evangelista; Sulamita da Silva Setúbal; Andreimar Martins Soares; Juliana Pavan Zuliani
Source:: Life sciences 2022 v.308 pp. 120962
ISSN:: 0024-3205
Subject:: L-amino-acid oxidase; NAD (coenzyme); NAD(P)H oxidase (H2O2-forming); Western blotting; caspase-1; cytokines; cytosol; fluorescent antibody technique; gene expression; humans; inflammasomes; lactate dehydrogenase; microarray technology; neutrophils; oxygen; protein kinase C; protein synthesis; reactive oxygen species; snake bites; snake venoms; transcriptome
Abstract:: ... l-Amino acid oxidase isolated from Calloselasma rhodostoma (Cr-LAAO) snake venom is a potent stimulus for neutrophil activation and production of inflammatory mediators, contributing to local inflammatory effects in victims of envenoming. Cr-LAAO triggered the activation of nicotinamide adenine dinucleotide phosphatase (NADPH) oxidase complex and protein kinase C (PKC)-α signaling protein for reac ...
DOI:: 10.1016/j.lfs.2022.120962
: https://doi.org/10.1016/j.lfs.2022.120962

46. Safranal Treatment Induces Sirt1 Expression and Inhibits Endoplasmic Reticulum Stress in Mouse Chondrocytes and Alleviates Osteoarthritis Progression in a Mouse Model

Author:: Zhao Zhang; Jingtao Wu; Cheng Teng; Jinquan Wang; Libo Wang; Long Wu; Wenhao Chen; Zhen Lin; Zhongke Lin
Source:: Journal of agricultural and food chemistry 2022 v.70 no.31 pp. 9748-9759
ISSN:: 1520-5118
Subject:: Western blotting; X-radiation; apoptosis; biomarkers; chondrocytes; endoplasmic reticulum; endoplasmic reticulum stress; extracellular matrix; fluorescent antibody technique; food chemistry; friction; immunohistochemistry; intraperitoneal injection; mice; osteoarthritis; oxidative stress; pathogenesis; reactive oxygen species
Abstract:: ... Osteoarthritis (OA) is an age-related degenerative disease. Oxidative stress (OS) modulates OA pathogenesis by enhancing chondrocyte apoptosis and extracellular matrix (ECM) degeneration via activation of the endoplasmic reticulum (ER) stress. Prior studies revealed that safranal plays a critical role in multiple diseases treatments, but there are no reports on its effect on OA. Therefore, investi ...
DOI:: 10.1021/acs.jafc.2c01773
: https://doi.org/10.1021/acs.jafc.2c01773

47. Salidroside Ameliorates Radiation Damage by Reducing Mitochondrial Oxidative Stress in the Submandibular Gland

Author:: Yue-Mei Sun; Xin-Yue Wang; Xin-Ru Zhou; Chong Zhang; Ke-Jian Liu; Fu-Yin Zhang; Bin Xiang
Source:: Antioxidants 2022 v.11 no.7 pp. -
ISSN:: 2076-3921
Subject:: Western blotting; antioxidant activity; apoptosis; caspase-3; catalase; glutathione; head and neck neoplasms; malondialdehyde; membrane potential; mitochondria; mitochondrial membrane; oxidative stress; pathophysiology; radiotherapy; rats; reactive oxygen species; salidroside; saliva; secretion; superoxide dismutase; transmission electron microscopy; ultrastructure
Abstract:: ... Radiotherapy for patients with head and neck cancer inevitably causes radiation damage to salivary glands (SGs). Overproduction of reactive oxygen species (ROS) leads to mitochondrial damage and is critical in the pathophysiology of SG radiation damage. However, mitochondrial-targeted treatment is unavailable. Herein, both in vitro and in vivo models of radiation-damaged rat submandibular glands ( ...
DOI:: 10.3390/antiox11071414
: https://doi.org/10.3390/antiox11071414

48. Salidroside, a phenyl ethanol glycoside from Rhodiola crenulata, orchestrates hypoxic mitochondrial dynamics homeostasis by stimulating Sirt1/p53/Drp1 signaling

Author:: Xiaobo Wang; Yan Tang; Na Xie; Jinrong Bai; Shengnan Jiang; Yi Zhang; Ya Hou; Xianli Meng
Source:: Journal of ethnopharmacology 2022 v.293 pp. 115278
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Rhodiola crenulata; Western blotting; active ingredients; adenosine triphosphate; altitude; blood circulation; brain damage; carbon dioxide; cell viability; confocal microscopy; ethanol; homeostasis; hypoxia; lactate dehydrogenase; malondialdehyde; membrane potential; mitochondria; mitochondrial membrane; oxidative stress; reactive oxygen species; salidroside; superoxide dismutase; surface plasmon resonance
Abstract:: ... Rhodiola crenulata is clinically used to combat hypobaric hypoxia brain injury at high altitude with the function of invigorating Qi and promoting blood circulation in Tibetan medicine. Salidroside (Sal), an active compound identified from Rhodiola species, has been shown to exert neuroprotective effects against hypoxic brain injury. However, its mitochondrial protective mechanisms remain largely ...
DOI:: 10.1016/j.jep.2022.115278
: https://doi.org/10.1016/j.jep.2022.115278

49. Selenium Ameliorates S. aureus-Induced Inflammation in Bovine Mammary Epithelial Cells by Regulating ROS-Induced NLRP3 Inflammasome

Author:: Yan Yang; Shenjin Lv; Zhennan Wang; Junjun Liu
Source:: Biological trace element research 2022 v.200 no.7 pp. 3171-3175
ISSN:: 0163-4984
Subject:: Staphylococcus aureus; Western blotting; caspase-1; cattle; epithelium; flow cytometry; inflammasomes; inflammation; reactive oxygen species; research; selenium
Abstract:: ... In this study, the regulation effects of selenium (Se) on the expression of pyrin domain-containing protein (NLRP) 3 inflammasome and reactive oxygen species (ROS) in bovine mammary epithelial cells (bMECs) infected by Staphylococcus aureus (S. aureus) were detected. bMECs were treated with 8 μmol/L Na₂SeO₃ for 12 h before infection with S. aureus for 2 h. Through flow cytometry, Western blot, and ...
DOI:: 10.1007/s12011-021-02924-7
: https://doi.org/10.1007/s12011-021-02924-7

50. Shensong Yangxin attenuates metabolic syndrome-induced atrial fibrillation via inhibition of ferroportin-mediated intracellular iron overload

Author:: Hong-Jie Yang; Bin Kong; Wei Shuai; Jing-jing Zhang; He Huang
Source:: Phytomedicine 2022 v.101 pp. 154086
ISSN:: 0944-7113
Subject:: Dependoparvovirus; Oriental traditional medicine; Western blotting; atrial fibrillation; diet; electrophysiology; fibrosis; fructose; gene ontology; histology; homeostasis; iron overload; males; models; protective effect; reactive oxygen species; sequence analysis; therapeutics
Abstract:: ... Shensong Yangxin (SSYX) is a traditional Chinese medicine been widely used clinically to treat various arrhythmias including atrial fibrillation (AF). However, the role and precise mechanism of SSYX in MS-induced AF have not yet been elucidated. To elucidate the protective effects of SSYX on MS-induced AF and its possible mechanisms of action. Male Wistar rats (180–220 g) were fed a 16-week high-c ...
DOI:: 10.1016/j.phymed.2022.154086
: https://doi.org/10.1016/j.phymed.2022.154086

51. Silibinin improves L-cell mass and function through an estrogen receptor-mediated antioxidative mechanism

Author:: Jinyu Wang; Luxin Zhang; Hao Cao; Xinyi Shi; Xiaorong Zhang; Zihao Gao; Katsumi Ikeda; Tingxu Yan; Ying Jia; Fanxing Xu
Source:: Phytomedicine 2022 v.99 pp. 154022
ISSN:: 0944-7113
Subject:: Silybum marianum; Western blotting; antagonists; antioxidant activity; apoptosis; blood serum; cell viability; desorption; duodenum; endocytosis; estrogen receptors; estrogens; fluorescent antibody technique; glucagon-like peptide 1; glucose; glutathione; homeostasis; hypoglycemia; palmitates; protective effect; protein synthesis; proteomics; reactive oxygen species; reproduction; silymarin
Abstract:: ... Silibinin, a major component of milk thistle extract silymarin, promotes hypoglycemia by activating estrogen receptor (ER) α and β-mediated pathways in pancreatic β-cells. Glucagon-like peptide-1 (GLP-1) is the enteroendocrine peptide produced in L-cells, and it controls glucose homeostasis through multiple pathways. The effect of silibinin on L-cell mass and function is still unknown. The protect ...
DOI:: 10.1016/j.phymed.2022.154022
: https://doi.org/10.1016/j.phymed.2022.154022

52. Toxoplasma gondii activates NLRP12 inflammasome pathway in the BALB/c murine model

Author:: Saba Rajabi; Adel Spotin; Mahmoud Mahami-Oskouei; Behzad Baradaran; Farhad Babaie; Yaghob Azadi; Paria Alizadeh; Reza Valadan; Aleksandra Barac; Ehsan Ahmadpour
Source:: Acta tropica 2022 v.225 pp. 106202
ISSN:: 0001-706X
Subject:: Toxoplasma gondii; Western blotting; animal models; caspase-1; caspase-3; cell death; gene expression; genes; immune response; inflammasomes; interleukin-18; mice; protein content; quantitative polymerase chain reaction; reactive oxygen species; tachyzoites; toxoplasmosis
Abstract:: ... The host resistance against Toxoplasma gondii (T. gondii) infection is related to the initiation of the immune response. The study aimed to investigate the role of the leucine-rich repeat family, pyrin domain -containing protein 12 (NLRP12), and cytoplasmic nucleotide-binding domain in the inflammasome-mediated cell death during murine toxoplasmosis. Groups of BALB/c mice (n = 10) were inoculated ...
DOI:: 10.1016/j.actatropica.2021.106202
: https://doi.org/10.1016/j.actatropica.2021.106202

53. Upregulation of nuclear factor E2-related factor 2 (Nrf2) represses the replication of herpes simplex virus type 1

Author:: Li Zhang; Jiao Wang; Zhan Wang; Ying Li; Hui Wang; Hongtu Liu
Source:: Virology journal 2022 v.19 no.1 pp. 23
ISSN:: 1743-422X
Subject:: Human alphaherpesvirus 1; Western blotting; antioxidant enzymes; heme oxygenase (biliverdin-producing); hydroquinone; oxidative stress; quantitative polymerase chain reaction; quinones; reactive oxygen species; transcription factors; virus replication
Abstract:: ... BACKGROUND: Nuclear factor E2-related factor 2 (Nrf2) is an important transcription factor which plays a pivotal role in detoxifying reactive oxygen species (ROS) and has been more recently shown to regulate inflammatory and antiviral responses. However, the role of Nrf2 in Herpes Simplex Virus type 1 (HSV-1) infection is still unclear. In this study, the interaction between the Nrf2 and HSV-1 rep ...
DOI:: 10.1186/s12985-021-01733-7
: https://doi.org/10.1186/s12985-021-01733-7

54. The anti-inflammatory activity by suppressing the TRAF6/MAPKs pathway of trishizukaol a from Sarcandra glabra

Author:: Rong Tao; Pengfei Tang; Juanjuan Gao; Jixin Li; Yunpeng Sun; Jun Luo; Yi Li
Source:: Phytomedicine 2022 v.98 pp. 153952
ISSN:: 0944-7113
Subject:: Sarcandra glabra; Western blotting; anti-inflammatory activity; bone fractures; drugs; flow cytometry; inflammation; interleukin-10; interleukin-6; lipopolysaccharides; macrophages; necrosis; neoplasms; nitric oxide; reactive oxygen species; sesquiterpenoids; therapeutics
Abstract:: ... Sarcandra glabra (Thunb.) Makino (Chloranthaceae) is abundant and shows important clinical effects. Traditionally, S.glabra is used to treat diseases involving inflammation, such as bone fracture and joint swelling. Lindenane-type sesquiterpenoids and dimers are the major anti-inflammatory components in S. glabra. Trishizukaol A (TSA), is an abundant lindenane sesquiterpenoid trimer in S.glabra, b ...
DOI:: 10.1016/j.phymed.2022.153952
: https://doi.org/10.1016/j.phymed.2022.153952

55. A high-value-added application of the stems of Rheum palmatum L. as a healthy food: the nutritional value, chemical composition, and anti-inflammatory and antioxidant activities

Author:: Xiaofei Shang; Lixia Dai; Jian He; Xiaorong Yang; Yu Wang; Bing Li; Jiyu Zhang; Hu Pan; Ilgekbayeva Gulnaz
Source:: Food & function 2022 v.13 no.9 pp. 4901-4913
ISSN:: 2042-650X
Subject:: Rheum palmatum; Western blotting; anti-inflammatory activity; antioxidant activity; biosafety; dietary supplements; flavonoids; healthy diet; inflammation; mechanism of action; membrane potential; mitochondrial membrane; nutrient content; nutritive value; oxidative stress; reactive oxygen species; rhubarb
Abstract:: ... Rhubarb has edible stems or stalks. In this paper, we investigated the nutritional value, chemical composition, and bioactivities of Rheum palmatum stems (SRP) and analyzed the mode of action. SRP exhibited biosafety and had nutritional value, with abundant essential amino acids and minerals. Based on network pharmacology and western blot tests, we found that it showed anti-inflammatory activity v ...
DOI:: 10.1039/d1fo04214a
: https://doi.org/10.1039/d1fo04214a

56. The natural compound from Garcinia bracteata mainly induces GSDME-mediated pyroptosis in esophageal cancer cells

Author:: Jia-Qi Tan; Zhuo Li; Gan Chen; Man Wu; Ji-Ling Feng; Si-Yuan Kong; Xiao-Qin Shi; Hong-Mei Zhang; Yuan-Zhi Lao; Hua Zhou; Li Zhang; Hong-Xi Xu
Source:: Phytomedicine 2022 v.102 pp. 154142
ISSN:: 0944-7113
Subject:: CRISPR-Cas systems; Garcinia bracteata; Western blotting; animals; antineoplastic activity; caspase-3; cell viability; drugs; esophageal neoplasms; flow cytometry; lactate dehydrogenase; microscopy; phosphorylation; plasma membrane; protein content; pyroptosis; reactive oxygen species; viability assays; xenotransplantation
Abstract:: ... Pyroptosis, an inflammatory form of programmed cell death (PCD), is reported to play important roles in the treatment of tumors. In our previous studies, we found that neobractatin (NBT), a caged prenylxanthone isolated from edible fruits of Garcinia bracteata C. Y. Wu ex Y. H. Li, showed anticancer effects against different cancer cells. However, the effect of NBT on pyroptosis is not well unders ...
DOI:: 10.1016/j.phymed.2022.154142
: https://doi.org/10.1016/j.phymed.2022.154142

57. The protective effect of quercetin on macrophage pyroptosis via TLR2/Myd88/NF-κB and ROS/AMPK pathway

Author:: Xing Luo; Xiaoyi Bao; Xiuzhu Weng; Xiaoxuan Bai; Yi Feng; Jianxin Huang; Shaoyu Liu; Haibo Jia; Bo Yu
Source:: Life sciences 2022 v.291 pp. 120064
ISSN:: 0024-3205
Subject:: Western blotting; agonists; anti-inflammatory activity; cell membranes; cell viability; cytoplasm; fluorescent antibody technique; inflammasomes; lactate dehydrogenase; macrophages; phosphorylation; propidium; protective effect; pyroptosis; quantitative polymerase chain reaction; quercetin; reactive oxygen species
Abstract:: ... Pyroptosis is a pro-inflammatory form of programmed cell death, which plays a vital role in the development of inflammatory diseases. As a natural flavonoid, quercetin has been shown to possess anti-inflammatory activity, but its effects on macrophage pyroptosis is still unclear. Therefore, this study aims to investigate the effects of quercetin on macrophage pyroptosis and the underlying mechanis ...
DOI:: 10.1016/j.lfs.2021.120064
: https://doi.org/10.1016/j.lfs.2021.120064

58. The protective mechanism of Grx2 in ultraviolet-B (UVB)-induced cataract formation

Author:: Yong Guo; Chenjun Guo; Jie Zhang; Xiaona Ning; Hong Yan
Source:: Biochemical and biophysical research communications 2022 v.613 pp. 107-112
ISSN:: 0006-291X
Subject:: Lens; Western blotting; animal models; antioxidant enzymes; cataract; computer software; enzyme-linked immunosorbent assay; genes; glutathione; irradiation; mice; opacity; pathogenesis; reactive oxygen species; research; statistical analysis; ultraviolet radiation
Abstract:: ... We established a mouse cataract model by irradiating Grx2 knockout (KO) and knock-in (KI) genetically modified mice with UVB to explore the protective mechanism of Grx2 against UVB lens damage. After irradiating Grx2 KO and Grx2 KI mice with UVB lamps, we observed and recorded the general physiological conditions and lens opacity of the mice. The crystalline grading system of the University of Oxf ...
DOI:: 10.1016/j.bbrc.2022.04.056
: https://doi.org/10.1016/j.bbrc.2022.04.056

59. A thioredoxin reductase 1 inhibitor pyrano [3,2-a] phenazine inhibits A549 cells proliferation and migration through the induction of reactive oxygen species production

Author:: Qifan Ding; Hengyu Wang; Ying Wang; Yuanyuan Lu
Source:: Molecular biology reports 2022 v.49 no.9 pp. 8835-8845
ISSN:: 0301-4851
Subject:: Western blotting; antineoplastic activity; cell movement; cell proliferation; enzyme activity; metastasis; molecular biology; neoplasm cells; oxidoreductases; reactive oxygen species; thioredoxins
Abstract:: ... BACKGROUND: Thioredoxin reductase 1 (TrxR1) inhibitor, pyrano [3,2-a] phenazine, named CPUL-1, was synthesized with potential anticancer activity. The aim of the present work was to explore the potential anti-proliferative and anti-metastatic ability of CPUL-1 against A549 cancer cell lines in vitro. METHODS AND RESULTS: First, Cell Counting Kit-8 (CCK8) assay was used to assess cell proliferation ...
DOI:: 10.1007/s11033-022-07733-2
: https://doi.org/10.1007/s11033-022-07733-2

60. 15-Hydroxy-8(17),13(E)-labdadiene-19-carboxylic acid (HLCA) inhibits proliferation and induces cell cycle arrest and apoptosis in ovarian cancer cells

Author:: Hadi Bakhtiari; Ali Gheysarzadeh; Mustafa Ghanadian; Mahmoud Aghaei
Source:: Life sciences 2021 v.267 pp. 118981
ISSN:: 0024-3205
Subject:: Juniperus; Western blotting; antineoplastic agents; apoptosis; caspase-9; cell cycle checkpoints; cyclin-dependent kinase; cyclins; cytotoxicity; flow cytometry; interphase; ovarian neoplasms; reactive oxygen species; therapeutics
Abstract:: ... 15-Hydroxy-8(17),13(E)-labdadiene-19-carboxylic acid (HLCA) isolated from Juniperus foetidissima, has been recently identified as an antiproliferative agent; however, the molecular basis of antiproliferative effects of HLCA remains unknown. To investigate it, the current study has emphasized the hypothesis that HLCA induced cell death is a consequence of intracellular reactive oxygen species (ROS) ...
DOI:: 10.1016/j.lfs.2020.118981
: https://doi.org/10.1016/j.lfs.2020.118981

61. Activation of PGC‐1α via isoliquiritigenin‐induced downregulation of miR‐138‐5p alleviates nonalcoholic fatty liver disease

Author:: Lu Wang; Xiaohui Wang; Lina Kong; Yingying Li; Kai Huang; Jingjing Wu; Changyuan Wang; Huijun Sun; Pengyuan Sun; Jiangning Gu; Haifeng Luo; Kexin Liu; Qiang Meng
Source:: Phytotherapy research 2022 v.36 no.2 pp. 899-913
ISSN:: 0951-418X
Subject:: Western blotting; bioinformatics; drugs; fatty liver; fluorescent antibody technique; histopathology; inflammation; interleukin-6; lipid metabolism; lipids; liver; luciferase; metabolic diseases; phytotherapy; quantitative polymerase chain reaction; reactive oxygen species; research
Abstract:: ... Nonalcoholic fatty liver disease (NAFLD), a metabolic disease, has received wide attention worldwide. However, there is no approved effective drug for NAFLD treatment. In the study, H&E and Oil Red O staining were employed to detect liver histopathological changes and the accumulation of lipid droplets. Quantitative real‐time PCR, Western blot, bioinformatics, luciferase assay, immunofluorescence ...
DOI:: 10.1002/ptr.7334
: https://doi.org/10.1002/ptr.7334

62. Agrimoniin sensitizes pancreatic cancer to apoptosis through ROS-mediated energy metabolism dysfunction

Author:: Xiandong Zhu; Yan Zhang; Yongqiang Wang; Hewei Zhang; Xiaowu Wang; Hengjie Tang; Hongjian Huang; Zijun Zhou; Bicheng Chen; Linxiao Sun
Source:: Phytomedicine 2022 v.96 pp. 153807
ISSN:: 0944-7113
Subject:: Agrimonia pilosa; Western blotting; acidification; apoptosis; cancer therapy; cell growth; cell proliferation; drug development; drug therapy; energy metabolism; flow cytometry; membrane potential; mitochondria; mitochondrial membrane; oxygen consumption; pancreatic neoplasms; polyphenols; protein synthesis; radiotherapy; reactive oxygen species; toxicity
Abstract:: ... Pancreatic cancer is a fatal tumor, which is one of the most common malignant tumors at present. Patients with pancreatic cancer also respond poorly to chemotherapy or radiation therapy and may be accompanied by serious adverse reactions. Therefore, to find an effective way to inhibit the initiation and progression of pancreatic cancer is important to improve the survival and development of patien ...
DOI:: 10.1016/j.phymed.2021.153807
: https://doi.org/10.1016/j.phymed.2021.153807

63. Antioxidant Biodegradable Covalent Cyclodextrin Frameworks as Particulate Carriers for Inhalation Therapy against Acute Lung Injury

Author:: Siyu He; Li Wu; Hongyu Sun; Di Wu; Caifen Wang; Xiaohong Ren; Qun Shao; Peter York; Jiabing Tong; Jie Zhu; Zegeng Li; Jiwen Zhang
Source:: ACS applied materials & interfaces 2022 v.14 no.34 pp. 38421-38435
ISSN:: 1944-8252
Subject:: Western blotting; aerodynamics; biodegradability; breathing; crosslinking; cyclodextrins; drugs; inflammation; intranasal administration; lactose; lungs; mannitol; medicinal properties; oxidants; particle size; reactive oxygen species
Abstract:: ... Drug therapies for acute lung injury (ALI) are far from satisfactory, primarily because drugs cannot specifically target the lungs. Direct delivery of drugs to the deep alveolar regions by inhalation administration is crucial for the treatment of ALI. However, conventional inhalable carriers such as lactose and mannitol are generally inactive. Therefore, the use of a novel pharmacologically active ...
DOI:: 10.1021/acsami.2c05220
: https://doi.org/10.1021/acsami.2c05220

64. Antitumor Effects of a Sesquiterpene Derivative from Marine Sponge in Human Breast Cancer Cells

Author:: Li-Yuan Bai; Jui-Hsin Su; Chang-Fang Chiu; Wei-Yu Lin; Jing-Lan Hu; Chia-Hsien Feng; Chih-Wen Shu; Jing-Ru Weng
Source:: Marine drugs 2021 v.19 no.5 pp. -
ISSN:: 1660-3397
Subject:: Porifera; Western blotting; apoptosis; autophagy; biomarkers; breast neoplasms; breasts; cell cycle checkpoints; epithelium; flow cytometry; humans; membrane potential; mitochondrial membrane; reactive oxygen species; sesquiterpenoids
Abstract:: ... In this study, the anti-proliferative effect of ilimaquinone, a sesquiterpene derivative from the marine sponge, in breast cancer cells was investigated. Ilimaquinone inhibited the proliferation of MCF-7 and MDA-MB-231 breast cancer cells with IC₅₀ values of 10.6 μM and 13.5 μM, respectively. Non-tumorigenic human breast epithelial cells were less sensitive to ilimaquinone than breast cancer cells ...
DOI:: 10.3390/md19050244
: https://doi.org/10.3390/md19050244

65. Antrodia camphorata extract (ACE)-induced apoptosis is associated with BMP4 expression and p53-dependent ROS generation in human colon cancer cells

Author:: Ruqian Ding; Xianling Ning; Min Ye; Yuxin Yin
Source:: Journal of ethnopharmacology 2021 v.268 pp. 113570
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Taiwanofungus camphoratus; Western blotting; antineoplastic agents; apoptosis; bioinformatics; cell viability; colorectal neoplasms; dose response; flow cytometry; fluorescence; fungi; gene expression; genes; gentian violet; humans; neoplasm cells; reactive oxygen species; sequence analysis; toxicity testing; transcriptomics; Taiwan
Abstract:: ... Antrodia camphorata (AC) is a rare functional fungus in Taiwan and is known as traditional Chinese medicine. It has been reported to inhibit proliferation and promote apoptosis in human cancer cells.Aim of the study: To investigate the potential mechanism of apoptosis induced in colon cancer cells by Antrodia camphorata extract (ACE).The MTT assay and crystal violet staining were used to determine ...
DOI:: 10.1016/j.jep.2020.113570
: https://doi.org/10.1016/j.jep.2020.113570

66. Apigenin exerts chemopreventive effects on lung injury induced by SiO2 nanoparticles through the activation of Nrf2

Author:: Yajun Wang; Wenhui Chang; Xuezheng Li; Zhe Jiang; Di Zhou; Yuan Feng; Bingxin Li; Gang Chen; Ning Li
Source:: Natural medicines 2022 v.76 no.1 pp. 119-131
ISSN:: 1340-3443
Subject:: Bletilla striata; Western blotting; apigenin; apoptosis; cell viability; chemoprevention; lungs; protective effect; reactive oxygen species
Abstract:: ... Apigenin (APG) is a flavonoid widely distributed in fruits, vegetables, and herbs, with comprehensive pharmacological effects. In this paper, we report that APG can elicit a protective effect, which is comparable to those induced by gymnoside II/n-BuOH extracts of Bletilla striata, on SiO₂-induced lung injury in vitro and in vivo. In vitro experiments showed that APG (25 μM) could restore the SiO₂ ...
DOI:: 10.1007/s11418-021-01561-7
: https://doi.org/10.1007/s11418-021-01561-7

67. Artemisia Leaf Extract protects against neuron toxicity by TRPML1 activation and promoting autophagy/mitophagy clearance in both in vitro and in vivo models of MPP+/MPTP-induced Parkinson's disease

Author:: Li-Kung Wu; Surbhi Agarwal; Chia-Hua Kuo; Yen-Lun Kung; Cecilia Hsuan Day; Pi-Yu Lin; Shinn-Zong Lin; Dennis Jine-Yuan Hsieh; Chih-Yang Huang; Chien-Yi Chiang
Source:: Phytomedicine 2022 v.104 pp. 154250
ISSN:: 0944-7113
Subject:: Artemisia argyi; Oriental traditional medicine; Parkinson disease; Western blotting; brain; calcium; cell viability; humans; leaf extracts; mitochondria; mitophagy; models; muscle strength; neurons; neuroprotective effect; pathogenesis; phosphatidylinositol 3-kinase; reactive oxygen species; therapeutics; toxicity; toxicity testing
Abstract:: ... Parkinson's disease (PD) is a neurodegenerative disorder involving the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Cellular clearance mechanisms, including the autophagy-lysosome pathway, are commonly affected in the pathogenesis of PD. The lysosomal Ca²⁺ channel mucolipin TRP channel 1 (TRPML1) is one of the most important proteins involved in the regulation ...
DOI:: 10.1016/j.phymed.2022.154250
: https://doi.org/10.1016/j.phymed.2022.154250

68. Autophagy induced by H. pylori VacA regulated the survival mechanism of the SGC7901 human gastric cancer cell line

Author:: Juan Luo; Luyan Bai; Jun Tao; Yu Wen; Mingke Li; Yunzhen Zhu; Sufeng Luo; Guangyu Pu; Lanqing Ma
Source:: Genes & genomics 2021 v.43 no.10 pp. 1223-1230
ISSN:: 1976-9571
Subject:: Helicobacter pylori; Western blotting; acetylcysteine; apoptosis; autophagy; cytotoxins; gene expression; genomics; humans; mitochondria; neoplasm cells; reactive oxygen species; stomach neoplasms; virulence
Abstract:: ... BACKGROUND: Vacuolating cytotoxin (VacA) is an important virulence factor of Helicobacter pylori (H. pylori). It was previously believed that VacA can trigger the cascade of apoptosis on mitochondria to lead to cell apoptosis. Recently, it was found that VacA can induce autophagy. However, the molecular mechanism by which VacA induces autophagy is largely unknown. OBJECTIVE: We aimed to explore th ...
DOI:: 10.1007/s13258-021-01151-7
: https://doi.org/10.1007/s13258-021-01151-7

69. Betulinic Acid–Doxorubicin-Drug Combination Induced Apoptotic Death via ROS Stimulation in a Relapsed AML MOLM-13 Cell Model

Author:: Milan Vu; Nick Kassouf; Sandra Appiah
Source:: Antioxidants 2021 v.10 no.9 pp. -
ISSN:: 2076-3921
Subject:: Western blotting; apoptosis; betulinic acid; cell lines; cytotoxicity; drugs; mitochondria; models; propidium; reactive oxygen species; reverse transcriptase polymerase chain reaction
Abstract:: ... In this study, cell death regulation and induction in AML cell line from a relapsed MLL-rearranged cell model (MOLM-13) was investigated with doxorubin (Dox) and betulinic acid (BetA), singly and in combination. CyQUANT Direct® and Annexin V/propidium iodide double staining were used to measure the cytotoxic and cell death induction effects of the compounds, respectively. Reactive oxygen species ( ...
DOI:: 10.3390/antiox10091456
: https://doi.org/10.3390/antiox10091456

70. Botanical formulation, TADIOS, alleviates lipopolysaccharide (LPS)-Induced acute lung injury in mice via modulation of the Nrf2-HO-1 signaling pathway

Author:: Wonwoo Lee; Chang Hyung Lee; Jungkyu Lee; Yoonseon Jeong; Jong-Hyung Park; In-Jeong Nam; Doo Suk Lee; Hyun Myung Lee; Jaehyun Lee; Nayoung Yun; Jisun Song; Sooyeon Choi; Sunyoung Kim
Source:: Journal of ethnopharmacology 2021 v.270 pp. 113795
ISSN:: 0378-8741
Subject:: Dioscorea polystachya; Oriental traditional medicine; RNA; Schizonepeta tenuifolia; Taraxacum officinale; Western blotting; acute respiratory distress syndrome; antioxidant activity; cell lines; dose response; eosin; ethanol; high performance liquid chromatography; interleukin-6; lipopolysaccharides; luciferase; lungs; macrophages; mice; myeloperoxidase; neutrophils; oxidative stress; plasmids; protein content; quality control; reactive oxygen species; Asia
Abstract:: ... TADIOS is an herbal formulation prepared from a mixture of Taraxacum officinale (L.) Weber ex F.H.Wigg, Dioscorea batatas Decaisne and Schizonepeta tenuifolia (Benth.) Briquet. These plants have traditionally been used in Asia to treat a variety of respiratory diseases. A bulk of literature on traditional Korean medicine describe their activities and functions for respiratory problems. Therefore, ...
DOI:: 10.1016/j.jep.2021.113795
: https://doi.org/10.1016/j.jep.2021.113795

71. Cadmium induced BEAS-2B cells apoptosis and mitochondria damage via MAPK signaling pathway

Author:: Xiangyu Cao; Mingyang Fu; Ruochen Bi; Xiaomei Zheng; Baorong Fu; Siqi Tian; Chengying Liu; Qijiu Li; Jianli Liu
Source:: Chemosphere 2021 v.263 pp. 128346
ISSN:: 0045-6535
Subject:: B-lymphocytes; Western blotting; air; apoptosis; asthma; cadmium; caspase-3; cell viability; epithelium; heavy metals; human health; humans; lung neoplasms; membrane potential; mitochondria; mitochondrial membrane; mitogen-activated protein kinase; oxidative stress; phosphorylation; pollutants; pulmonary emphysema; reactive oxygen species; rhodamines; soil; toxicity; toxicity testing
Abstract:: ... Cadmium, a heavy metal pollutant in industrial production, is found in air, water and soil, which is harmful to human health and can lead to diseases, such as asthma, lung cancer, and emphysema. In this study, the toxicity of cadmium on human bronchial epithelial cells (BEAS-2B) was investigated. Cell viability, mitochondrial membrane potential, reactive oxygen species (ROS) level, apoptosis and t ...
DOI:: 10.1016/j.chemosphere.2020.128346
: https://doi.org/10.1016/j.chemosphere.2020.128346

72. Cigarette smoke extract reduces FOXO3a promoting tumor progression and cell migration in lung cancer

Author:: Serena Di Vincenzo; Claudia Sangiorgi; Maria Ferraro; Marco Buscetta; Chiara Cipollina; Elisabetta Pace
Source:: Toxicology 2021 v.454 pp. 152751
ISSN:: 0300-483X
Subject:: Western blotting; cadherins; cell movement; cigarettes; death; flow cytometry; fluorometry; glycolysis; lactic acid; lung neoplasms; metastasis; mitochondria; neoplasm cells; neoplasm progression; oxidative stress; pro-apoptotic proteins; quantitative polymerase chain reaction; reactive oxygen species; smoke; toxicology; transcription factors
Abstract:: ... Lung cancer is the leading cause of cancer death worldwide, and the carcinogens in tobacco smoke play a role in its progression and metastasis. The related molecular events are largely unknown. FOXO3a is a transcription factor considered a tumor suppressor. Its inhibition leads to cell transformation, tumor progression and metastasis. The aim of this study was to investigate, in different types of ...
DOI:: 10.1016/j.tox.2021.152751
: https://doi.org/10.1016/j.tox.2021.152751

73. Cigarette smoke induces apoptosis via 18 kDa translocator protein in human bronchial epithelial cells

Author:: Yuting Cui; Yingmin Liang; Mary S.M. Ip; Judith C.W. Mak
Source:: Life sciences 2021 v.265 pp. 118862
ISSN:: 0024-3205
Subject:: Western blotting; agonists; antagonists; apoptosis; benzodiazepines; cigarettes; epithelium; humans; interleukin-8; ligands; membrane potential; mitochondria; mitochondrial membrane; permeability; pneumocytes; protein synthesis; reactive oxygen species; respiratory tract diseases; risk factors; smoke
Abstract:: ... The 18 kDa translocator protein (TSPO) – also known as peripheral benzodiazepine receptor, is found to be expressed in lung epithelium and pneumocytes, which is closely associated with the mitochondrial permeability transition pore (mPTP) and apoptosis. Cigarette smoking, a key risk factor for the development of chronic obstructive pulmonary disease (COPD), is known to induce apoptosis. We aimed t ...
DOI:: 10.1016/j.lfs.2020.118862
: https://doi.org/10.1016/j.lfs.2020.118862

74. Combination of cyanidin‐3‐O‐glucoside and cisplatin induces oxidative stress and apoptosis in HeLa cells by reducing activity of endogenous antioxidants, increasing bax/bcl‐2 mRNA expression ratio, and downregulating Nrf2 expression

Author:: Xu Li; Jingjing Mu; Yang Lin; Jin Zhao; Xianjun Meng
Source:: Journal of food biochemistry 2021 v.45 no.7 pp. e13806
ISSN:: 0145-8884
Subject:: Western blotting; apoptosis; catalase; cisplatin; cytotoxicity; fluorescence; gene expression; glutathione; glutathione peroxidase; heme oxygenase (biliverdin-producing); hepatotoxicity; malondialdehyde; models; nausea; neoplasm cells; nephrotoxicity; oxidative stress; quinones; reactive oxygen species; superoxide dismutase; therapeutics; uterine cervical neoplasms
Abstract:: ... Investigation on potentiation of existing drugs with natural compounds to enhance efficacy and reduce toxic effect of the drugs has been increasing in recent years. This paper reports cytotoxic effect (apoptosis‐related and oxidative stress‐related effect) of cyanidin‐3‐O‐glucoside (C3G), cisplatin (DDP), and their combination (C3G‐DDP) on cervical cancer HeLa cells. Concentration of intracellular ...
DOI:: 10.1111/jfbc.13806
: https://doi.org/10.1111/jfbc.13806

75. Corn peptides improved obesity-induced non-alcoholic fatty liver disease through relieving lipid metabolism, insulin resistance and oxidative stress

Author:: Kang Wei; Yang Wei; Weidong Xu; Feng Lu; Haile Ma
Source:: Food & function 2022 v.13 no.10 pp. 5782-5793
ISSN:: 2042-650X
Subject:: Western blotting; animal models; bioactive properties; blood lipids; body weight; corn; fatty liver; fructose; glucose tolerance; hepatocytes; high fat diet; histology; human health; humans; insulin resistance; lipid metabolism; lipids; liver; liver function; oxidative stress; peptides; protein synthesis; reactive oxygen species; weight gain
Abstract:: ... Non-alcoholic fatty liver disease (NAFLD) is increasingly threatening human health. The remarkable effects of corn peptides (CPs) as bioactive peptides on liver protection have attracted much attention. Nevertheless, the specific effect of CPs on NAFLD remains unclear. The present study was designed to investigate the efficacy of CPs in the prevention and auxiliary treatment of high-fat diet (HFD) ...
DOI:: 10.1039/d2fo00199c
: https://doi.org/10.1039/d2fo00199c

76. Crocin alleviates the inflammation and oxidative stress responses associated with diabetic nephropathy in rats via NLRP3 inflammasomes

Author:: Linjuan Zhang; Mengmeng Jing; Quan Liu
Source:: Life sciences 2021 v.278 pp. 119542
ISSN:: 0024-3205
Subject:: Western blotting; blood glucose; blood serum; diabetic nephropathy; dihydroethidium; enzyme-linked immunosorbent assay; fibrosis; fluorescence; hyperglycemia; inflammasomes; inflammation; insulin; interleukin-18; kidneys; metabolism; oxidative stress; protective effect; rats; reactive oxygen species; streptozotocin
Abstract:: ... Currently, drugs for the treatment of diabetic nephropathy (DN) are lacking. This study aimed to explore the protective effect of crocin on DN. Diabetes was induced in rats by streptozotocin (STZ), and changes in metabolism and renal parameters after crocin treatment were measured. Dihydroethidium (DHE) fluorescence and superoxide generation were used to detect the levels of reactive oxygen specie ...
DOI:: 10.1016/j.lfs.2021.119542
: https://doi.org/10.1016/j.lfs.2021.119542

77. Curcumin sensitizes carboplatin treatment in triple negative breast cancer through reactive oxygen species induced DNA repair pathway

Author:: Genjin Wang; Peng Duan; Zhengkuo Wei; Feng Liu
Source:: Molecular biology reports 2022 v.49 no.4 pp. 3259-3270
ISSN:: 0301-4851
Subject:: DNA damage; DNA repair; Western blotting; antineoplastic activity; apoptosis; breast neoplasms; cell viability; curcumin; drug therapy; flow cytometry; molecular biology; reactive oxygen species
Abstract:: ... BACKGROUND: As patients with triple-negative breast cancer (TNBC) have a very weak response to hormone inhibition or anti-HER2 therapy, traditional chemotherapy is commonly used in these patients. Recently, carboplatin has been approved for the clinical treatment of TNBC. However, several patients exhibit resistance to carboplatin treatment. Therefore, strategies to enhance the antitumor effect of ...
DOI:: 10.1007/s11033-022-07162-1
: https://doi.org/10.1007/s11033-022-07162-1

78. D319 induced antifungal effects through ROS-mediated apoptosis and inhibited isocitrate lyase in Candida albicans

Author:: Yanjiao Ding; Kai Zhang; Yiqiang Yin; Jiyong Wu
Source:: Biochimica et biophysica acta 2022 v.1866 no.2 pp. 130050
ISSN:: 0304-4165
Subject:: Candida albicans; Western blotting; animal models; antifungal agents; antifungal properties; apoptosis; flow cytometry; fluorescence microscopy; fungi; isocitrate lyase; mechanism of action; minimum inhibitory concentration; mutants; opportunistic pathogens; quinoline; reactive oxygen species; spectral analysis; survival rate
Abstract:: ... Candida albicans (C. albicans) is an opportunistic pathogen that can cause superficial and life-threatening systemic infections in immunocompromised patients. However, the available clinically antifungals are limited. Therefore, the development of effective antifungal agents and therapies is urgently needed. Quinoline type of compounds were reported to possess potent anti-fungal effect. A series o ...
DOI:: 10.1016/j.bbagen.2021.130050
: https://doi.org/10.1016/j.bbagen.2021.130050

79. Differential effects of phenolic extracts from red‐fleshed apple peels and flesh induced G1 cell cycle arrest and apoptosis in human breast cancer MDA‐MB‐231 cells

Author:: Cui Xia Li; Zhen Xian Lin; Xian Hua Zhao; Wei Fang Zuo; Nan Wang; Zong Ying Zhang; Xue Sen Chen
Source:: Journal of food science 2021 v.86 no.9 pp. 4209-4222
ISSN:: 0022-1147
Subject:: Western blotting; apoptosis; apple peels; apples; breast neoplasms; cell cycle checkpoints; cell proliferation; cyclins; flavonoids; food science; humans; polyphenols; pulp; reactive oxygen species
Abstract:: ... Red‐fleshedapples are preferredbecause of their high content of phenolics and antioxidants in peel and pulp. Herein, we evaluated the mechanisms of apple peel polyphenolic extracts (APP) and apple flesh polyphenolic extracts (AFP) from the new red‐fleshed apple in inhibiting cell proliferation and inducing apoptosis on human breast cancer MDA‐MB‐231 cells. The antiproliferative activities were det ...
DOI:: 10.1111/1750-3841.15863
: https://doi.org/10.1111/1750-3841.15863

80. Differentially expressed genes induced by β-caryophyllene in a rat model of cerebral ischemia-reperfusion injury

Author:: Shengwei Liu; Jingdong Liu; Yuchun Wang; Ling Deng; Sha Chen; Xuan Wang; Tianrui Zuo; Qingwen Hu; Jiangyan Rao; Qian Wang; Zhi Dong
Source:: Life sciences 2021 v.273 pp. 119293
ISSN:: 0024-3205
Subject:: Western blotting; angiogenesis; animal models; cell movement; cytokines; gene expression regulation; gene ontology; ischemia; microRNA; protein-protein interactions; rats; reactive oxygen species; sequence analysis; stroke; therapeutics; transcription factors
Abstract:: ... Experimental studies have shown that β-caryophyllene (BCP) improved neurological deficits of cerebral ischemia-reperfusion injury (CIRI) rats resulting from Middle Cerebral Artery Occlusion (MCAO). However, research on targets of BCP on CIRI has not been completed. In this study, the mRNA sequencing was used to distinguish various therapeutic multiple targets of BCP on CIRI. Differentially express ...
DOI:: 10.1016/j.lfs.2021.119293
: https://doi.org/10.1016/j.lfs.2021.119293

81. Down-regulation of IGHG1 enhances Protoporphyrin IX accumulation and inhibits hemin biosynthesis in colorectal cancer by suppressing the MEK-FECH axis

Author:: Guangjian Yang; Gang Li; Xuemei Du; Wenting Zhou; Xiaohong Zou; Yuanfu Liu; Hong Lv; Zhenjiang Li
Source:: Open life sciences 2021 v.16 no.1 pp. 930-936
ISSN:: 2391-5412
Subject:: Western blotting; biosynthesis; cell proliferation; cell viability; colorectal neoplasms; death; fluorescent dyes; immunoglobulins; mitogen-activated protein kinase; neoplasm cells; photochemotherapy; protoporphyrin; reactive oxygen species
Abstract:: ... Immunoglobulin γ-1 heavy chain constant region (IGHG1) is a functional isoform of immunoglobulins and plays an important role in the cytolytic activity of immune effector cells. Dysregulated IGHG1 was implicated in the occurrence and development of various tumors. Protoporphyrin IX (PpIX) is an endogenous fluorophore and is used in photodynamic therapy, which induces the generation of reactive oxy ...
DOI:: 10.1515/biol-2021-0098
: https://doi.org/10.1515/biol-2021-0098

82. ERK/p38/ROS burst responses to environmentally relevant concentrations of diphenyl phosphate-evoked neutrophil extracellular traps formation: Assessing the role of autophagy

Author:: Siwen Li; Yu Ma; Shuzi Ye; Die Hu; Fang Xiao
Source:: Journal of hazardous materials 2022 v.421 pp. 126758
ISSN:: 0304-3894
Subject:: Western blotting; autophagy; biphenyl; death; dissection; flow cytometry; immunotoxicity; mitogen-activated protein kinase; monitoring; neutrophils; organophosphorus compounds; phosphates; rapamycin; reactive oxygen species
Abstract:: ... Organophosphorus compounds were proposed to impair immune surveillance and increase the total burden of pathogens. However, scarce attention has been paid to the effects of organophosphate flame retardants (OPFRs) on neutrophils. Previous literature outlined that neutrophil extracellular traps (NETs) death (NETosis) is associated with autophagy-related signaling. Here we found that 20 μM diphenyl ...
DOI:: 10.1016/j.jhazmat.2021.126758
: https://doi.org/10.1016/j.jhazmat.2021.126758

83. Effects of Lactobacillus kefiri fermentation supernatant on skin aging caused by oxidative stress

Author:: Yuzhi Zhang; Pingping Liu; Hao Fu; Dongdong Wang; Dan Zhao; Jiachan Zhang; Changtao Wang; Meng Li
Source:: Journal of functional foods 2022 v.96 pp. 105222
ISSN:: 1756-4646
Subject:: Lactobacillus kefiri; Western blotting; antioxidant activity; antioxidant enzymes; autophagy; collagen; enzyme activity; fermentation; fibroblasts; food composition; free radicals; functional foods; gene expression; human health; interstitial collagenase; malondialdehyde; molecular biology; oxidative stress; protein synthesis; reactive oxygen species; reverse transcriptase polymerase chain reaction; skin (animal); toxicity; yogurt
Abstract:: ... Lactobacillus kefiri is a beneficial bacteria that is often used to make yogurt only, and is beneficial to human health when it is used in food fermentation. In this article, a fermentation supernatant (LAF) is prepared by culturing Lactobacillus kefiri, and the anti-aging effects of LAF are evaluated at the biochemical, cellular, and molecular biology levels. The antioxidant activity of LAF is co ...
DOI:: 10.1016/j.jff.2022.105222
: https://doi.org/10.1016/j.jff.2022.105222

84. Elevated reactivity of Apelin inhibited renal fibrosis induced by chronic intermittent hypoxia

Author:: Yurong Wang; Yan Wang; Kai Xue; Feng Gao; Chengde Li; Hui Fang
Source:: Archives of biochemistry and biophysics 2021 v.711 pp. 109021
ISSN:: 0003-9861
Subject:: Western blotting; actin; animal models; antagonists; biophysics; cell proliferation; collagen; fibrosis; humans; hypoxia; immunohistochemistry; inflammation; malondialdehyde; muscles; necrosis; neoplasms; oxidative stress; reactive oxygen species; superoxide dismutase
Abstract:: ... Apelin and its receptor angiotensin receptor - like 1 (APJ) are closely related to renal fibrosis, but their specific roles in renal fibrosis are still controversial. In this article, we discussed the role of Apelin/APJ system in renal fibrosis and its mechanism.Chronic intermittent hypoxia (CIH) rat model was established to induce the environment of renal fibrosis and a competitive antagonist of ...
DOI:: 10.1016/j.abb.2021.109021
: https://doi.org/10.1016/j.abb.2021.109021

85. Emodin induces apoptosis and suppresses non-small-cell lung cancer growth via downregulation of sPLA2-IIa

Author:: Fang-Yuan Zhang; Run-Ze Li; Cong Xu; Xing-Xing Fan; Jia-Xin Li; Wei-Yu Meng; Xuan-Run Wang; Tu-Liang Liang; Xiao-Xiang Guan; Hu-Dan Pan; Liang Liu; Xiao-Jun Yao; Qi Biao Wu; Elaine Lai-Han Leung
Source:: Phytomedicine 2022 v.95 pp. 153786
ISSN:: 0944-7113
Subject:: Rheum officinale; Western blotting; antineoplastic activity; apoptosis; cell cycle; cell lines; cytotoxicity; emodin; enzyme inhibition; flow cytometry; lung neoplasms; lungs; mutants; phospholipases; reactive oxygen species; therapeutics
Abstract:: ... Lung cancer has become the principal cause of cancer-related deaths. Emodin is a Chinese herb-derived compound extracted from the roots of Rheum officinale that exhibits numerous pharmacological characteristics. Secretory phospholipase A2-IIa (sPLA2-IIa) is overexpressed in cancers and plays an important role in cancer development.This study aims to investigate the anti-tumor mechanism of emodin i ...
DOI:: 10.1016/j.phymed.2021.153786
: https://doi.org/10.1016/j.phymed.2021.153786

86. Estrogen Decreases Cytoskeletal Organization by Forming an ERα/SHP2/c-Src Complex in Osteoclasts to Protect against Ovariectomy-Induced Bone Loss in Mice

Author:: Hyun-Jung Park; Malihatosadat Gholam-Zadeh; Sun-Young Yoon; Jae-Hee Suh; Hye-Seon Choi
Source:: Antioxidants 2021 v.10 no.4 pp. -
ISSN:: 2076-3921
Subject:: NAD(P)H oxidase (H2O2-forming); Western blotting; acid phosphatase; actin; antagonists; blood serum; bone resorption; botulinum toxin; collagen; cytoskeleton; estrogen receptors; estrogens; femur; guanine nucleotide exchange factors; ligands; osteoclasts; ovariectomy; oxidation; phosphorylation; precipitin tests; protein-tyrosine-phosphatase; proto-oncogenes; reactive oxygen species; sarcoma
Abstract:: ... Loss of ovarian function is closely related to estrogen (E₂) deficiency, which is responsible for increased osteoclast (OC) differentiation and activity. We aimed to investigate the action mechanism of E₂ to decrease bone resorption in OCs to protect from ovariectomy (OVX)-induced bone loss in mice. In vivo, tartrate-resistant acid phosphatase (TRAP) staining in femur and serum carboxy-terminal co ...
DOI:: 10.3390/antiox10040619
: https://doi.org/10.3390/antiox10040619

87. Ficus deltoidea: Potential inhibitor of pro-inflammatory mediators in lipopolysaccharide-induced activation of microglial cells

Author:: Siti Zaidathul Iman Zolkiffly; Johnson Stanslas; Hafizah Abdul Hamid; Muhammad Zulfadli Mehat
Source:: Journal of ethnopharmacology 2021 v.279 pp. 114309
ISSN:: 0378-8741
Subject:: Ficus deltoidea; Western blotting; cytotoxicity; fruits; high performance liquid chromatography; interleukin-6; lipopolysaccharides; neuroprotective effect; nitric oxide; reactive oxygen species; traditional medicine; transcription factor NF-kappa B; tumor necrosis factor-alpha; viability; Malaysia
Abstract:: ... Ficus deltoidea Jack (FD) is widely consumed in traditional medicine as a treatment for various diseases in Malaysia. Each part of the plant such as its leave, stem, fruit and root are used traditionally to treat different types of diseases. Vitexin and isovitexin are bioactive compounds abundantly found in the leaves of FD that possessed many pharmacological properties including neuroprotection. ...
DOI:: 10.1016/j.jep.2021.114309
: https://doi.org/10.1016/j.jep.2021.114309

88. Freezability biomarkers in the epididymal spermatozoa of swamp buffalo

Author:: Marvin Bryan Segundo Salinas; Teepakorn Lertwichaikul; Chakorn Khunkaew; Sukolrat Boonyayatra; Korawan Sringarm; Phongsakorn Chuammitri; Anucha Sathanawongs
Source:: Cryobiology 2022 v.106 pp. 39-47
ISSN:: 0011-2240
Subject:: H-transporting ATP synthase; Western blotting; artificial insemination; biomarkers; buffaloes; cryobiology; cryopreservation; epididymis; epithelium; fluorescence; freeze-thaw cycles; glutathione transferase; immunohistochemistry; kinematics; lipid peroxidation; malondialdehyde; oxidative stress; reactive oxygen species; semen; spermatozoa; swamps
Abstract:: ... As an alternative to ejaculated semen, epididymal spermatozoa (ES) can be recovered and cryopreserved for use in artificial insemination and other assisted reproductive technologies. However, variabilities in the sperm response to freeze-thaw procedures challenge its inherent value. Therefore, the present study aims to clarify the freezability phenomena in the swamp buffalo ES, where pieces of lit ...
DOI:: 10.1016/j.cryobiol.2022.04.005
: https://doi.org/10.1016/j.cryobiol.2022.04.005

89. Glaucocalyxin A impairs tumor growth via amplification of the ATF4/CHOP/CHAC1 cascade in human oral squamous cell carcinoma

Author:: Xin Wang; Ming-Jing He; Xiao-Jie Chen; Yu-Ting Bai; Gang Zhou
Source:: Journal of ethnopharmacology 2022 v.290 pp. 115100
ISSN:: 0378-8741
Subject:: Isodon (Lamiaceae); Western blotting; acetylcysteine; antineoplastic activity; apoptosis; cell proliferation; endoplasmic reticulum; homeostasis; humans; medicinal plants; mitochondria; models; mouth neoplasms; protein synthesis; quantitative polymerase chain reaction; reactive oxygen species; squamous cell carcinoma; traditional medicine; transfection; viability; xenotransplantation
Abstract:: ... The natural extract glaucocalyxin A (GLA), purified from the aboveground sections of the Chinese traditional medicinal herb Rabdosia japonica (Burm. f.) Hara var. glaucocalyx (Maxim.) Hara, has various pharmacological benefits, such as anti-bacterial, anti-coagulative, anti-neoplastic, and anti-inflammatory activities. Although GLA has shown anti-tumor activity against various cancers, the therape ...
DOI:: 10.1016/j.jep.2022.115100
: https://doi.org/10.1016/j.jep.2022.115100

90. Glaucocalyxin A induces cell cycle arrest and apoptosis via inhibiting NF-κB/p65 signaling pathway in melanoma cells

Author:: Jiasheng Chen; Wancong Zhang; Chen Pan; Jufeng Fan; Xiaoping Zhong; Shijie Tang
Source:: Life sciences 2021 v.271 pp. 119185
ISSN:: 0024-3205
Subject:: Isodon (Lamiaceae); Western blotting; animals; antineoplastic agents; apoptosis; cell cycle checkpoints; cell proliferation; diterpenoids; flow cytometry; fluorescent antibody technique; immunohistochemistry; melanoma; membrane potential; metastasis; mitochondria; mitochondrial membrane; phosphorylation; prognosis; protein synthesis; reactive oxygen species; toxicity
Abstract:: ... Melanoma is a malignant tumor of the skin with a high metastasis rate and poor prognosis. Glaucocalyxin A (GLA), isolated from Rabdosia japonica, is a diterpenoid compound with anticancer properties. Here, we investigated the anticancer properties and explored the mechanisms underlying GLA activity in melanoma cells in vitro and in vivo. Cell Counting Kit-8 and colony formation assays were used to ...
DOI:: 10.1016/j.lfs.2021.119185
: https://doi.org/10.1016/j.lfs.2021.119185

91. High-sugar high-fat treatment induces autophagy of retinal microvascular endothelial cells

Author:: Xinbang Mao; Yuwen Wan; Sidan Huang; Yan Wang; Yunfei Wu; Shenghong Zhou; Xia Feng; Caixia Gao; Chen Wu
Source:: Biochemical and biophysical research communications 2022 v.600 pp. 22-28
ISSN:: 0006-291X
Subject:: Western blotting; autophagy; cathepsin B; chloroquine; flow cytometry; fluorescent antibody technique; glucose; low density lipoprotein; oxidation; rats; reactive oxygen species; research; resveratrol
Abstract:: ... To investigate the role of high-sugar high-fat treatment in inducing autophagy of rat retinal microvascular endothelial cells. The optimal concentrations and time points of glucose and oxidized low-density lipoprotein (ox-LDL) in inducing rat retinal microvascular endothelial cells were determined by examining the proliferate rate by CCK-8 assay. They were divided into control group (blank control ...
DOI:: 10.1016/j.bbrc.2022.02.032
: https://doi.org/10.1016/j.bbrc.2022.02.032

92. Immune-Enhancing Effects of a Novel Glucan from Purple Sweet Potato Ipomoea batatas (L.) Lam on RAW264.7 Macrophage Cells via TLR2- and TLR4-Mediated Pathways

Author:: Chenfeng Ji; Ziyi Zhang; Jinrui Chen; Dongxue Song; Bing Liu; Jun Li; Rongyu Liu; Junbo Niu; Di Wang; Na Ling; Zheng Qi; Wenlan Li
Source:: Journal of agricultural and food chemistry 2021 v.69 no.32 pp. 9313-9325
ISSN:: 1520-5118
Subject:: DNA replication; Ipomoea batatas; Toll-like receptor 2; Western blotting; cell structures; cytokines; food chemistry; glucans; immunomodulation; interferometry; macrophages; mitogen-activated protein kinase; mitosis; nitric oxide; phagocytosis; reactive oxygen species; sweet potatoes
Abstract:: ... PSPP-1 was obtained from purple sweet potato, and the effects of PSPP-1 on the immune modulation on macrophage cells were investigated for the first time. PSPP-1 promoted RAW264.7 proliferation and increased the total cell percentage in DNA synthesis and mitosis phases, and the cell morphology changed in volume and appearance. Additionally, the RAW264.7 immune functions of phagocytic activity and ...
DOI:: 10.1021/acs.jafc.1c03850
: https://doi.org/10.1021/acs.jafc.1c03850

93. In vitro antimetastatic activity of Momordica balsamina crude acetone extract in HT‐29 human colon cancer cells

Author:: Karabo Serala; Paul Steenkamp; Leseilane Mampuru; Sharon Prince; Kgomotso Poopedi; Vusi Mbazima
Source:: Environmental toxicology 2021 v.36 no.11 pp. 2196-2205
ISSN:: 1520-4081
Subject:: Momordica balsamina; Western blotting; acetone; acridine orange; adhesion; antineoplastic activity; cell adhesion; cell movement; chemical constituents of plants; colorectal neoplasms; cytotoxicity; ecotoxicology; ethidium; humans; metastasis; reactive oxygen species; ultra-performance liquid chromatography
Abstract:: ... Plant‐derived compounds and/or extracts have proven to be beneficial for the treatment of a broad spectrum of cancers with minimal side effects. In this study, we investigated whether a crude acetone extract of Momordica balsamina (MBE) can interfere with the metastatic ability of HT‐29 colorectal cancer (CRC) cells. The phytochemical composition of MBE was determined by ultra‐performance liquid c ...
DOI:: 10.1002/tox.23333
: https://doi.org/10.1002/tox.23333

94. Inhibitory Effects of 6,8-Diprenylorobol on Endometriosis Progression in Humans by Disrupting Calcium Homeostasis and Mitochondrial Function

Author:: Jisoo Song; Gwonhwa Song; Sunwoo Park; Whasun Lim
Source:: Antioxidants 2022 v.11 no.1 pp. -
ISSN:: 2076-3921
Subject:: Maclura tricuspidata; Western blotting; adjuvants; borates; calcium; cell cycle; cell death; cell proliferation; endometriosis; endometrium; females; flavonoids; homeostasis; melanin; membrane potential; mitochondria; mitochondrial membrane; mitogen-activated protein kinase; reactive oxygen species; ruthenium red; therapeutics; uterine cervical neoplasms
Abstract:: ... 6,8-Diprenylorobol is a flavonoid compound extracted from Cudrania tricuspidata. It has various biological functions, such as inhibiting melanin synthesis and inducting cell death in cancerous cells. In addition, Cudrania tricuspidata is known to be effective in female diseases, and previous studies have shown anticancer effects in cervical cancer, a female reproductive disease. Outside of that, C ...
DOI:: 10.3390/antiox11010171
: https://doi.org/10.3390/antiox11010171

95. Intrarenal Arterial Transplantation of Dexmedetomidine Preconditioning Adipose Stem-Cell-Derived Microvesicles Confers Further Therapeutic Potential to Attenuate Renal Ischemia/Reperfusion Injury through miR-122-5p/Erythropoietin/Apoptosis Axis

Author:: Yu-Hsuan Cheng; Kuo-Hsin Chen; Yi-Ting Sung; Chih-Ching Yang; Chiang-Ting Chien
Source:: Antioxidants 2022 v.11 no.9 pp. -
ISSN:: 2076-3921
Subject:: Western blotting; apoptosis; blood; caspases; creatinine; dexmedetomidine; erythropoietin; hemodynamics; hypoxia; immunohistochemistry; intravenous injection; ischemia; lungs; microarray technology; models; oxidative stress; reactive oxygen species; reperfusion injury; urea nitrogen
Abstract:: ... Intravenous adipose mesenchymal stem cells (ADSCs) attenuate renal ischemia/reperfusion (IR) injury but with major drawbacks, including the lack of a specific homing effect after systemic infusion, cell trapping in the lung, and early cell death in the damaged microenvironment. We examined whether intrarenal arterial transplantation of dexmedetomidine (DEX) preconditioning ADSC-derived microvesicl ...
DOI:: 10.3390/antiox11091702
: https://doi.org/10.3390/antiox11091702

96. Iridium Complex-Loaded Sorafenib Nanocomposites for Synergistic Chemo-photodynamic Therapy of Hepatocellular Carcinoma

Author:: Weinire Abuduwaili; Xiang Wang; An-Tian Huang; Jia-Lei Sun; Ru-Chen Xu; Guang-Cong Zhang; Zhi-Yong Liu; Fu Wang; Chang-Feng Zhu; Tao-Tao Liu; Ling Dong; Ji-Min Zhu; Shu-Qiang Weng; Yuhao Li; Xi-Zhong Shen
Source:: ACS applied materials & interfaces 2022 v.14 no.33 pp. 37356-37368
ISSN:: 1944-8252
Subject:: Western blotting; apoptosis; bioavailability; biocompatibility; blood serum; cell proliferation; cytotoxicity; hemolysis; hepatoma; iridium; irradiation; models; nanocomposites; necrosis; neoplasm cells; photochemotherapy; photosensitizing agents; reactive oxygen species; xenotransplantation
Abstract:: ... Although sorafenib, a multi-kinase inhibitor, has provided noteworthy benefits in patients with hepatocellular carcinoma (HCC), the inevitable side effects, narrow therapeutic window, and low bioavailability seriously affect its clinical application. To be clinically distinctive, innovative drugs must meet the needs of reaching tumor tissues and cause limited side effects to normal organs and tiss ...
DOI:: 10.1021/acsami.2c07247
: https://doi.org/10.1021/acsami.2c07247

97. Iron Overload Induces Apoptosis and Cytoprotective Autophagy Regulated by ROS Generation in Mc3t3-E1 Cells

Author:: Guanpeng Xu; Xi Li; Zhiyong Zhu; Huisheng Wang; Xizhuang Bai
Source:: Biological trace element research 2021 v.199 no.10 pp. 3781-3792
ISSN:: 0163-4984
Subject:: NAD(P)H oxidase (H2O2-forming); Western blotting; acetylcysteine; ammonium; apoptosis; autophagy; caspase-3; cell viability; chloroquine; citrates; flow cytometry; fluorescent antibody technique; hemochromatosis; osteoblasts; osteoporosis; postmenopause; reactive oxygen species; research; risk factors; sickle cell anemia; thalassemia
Abstract:: ... Iron overload has been found very common in diseases such as hereditary hemochromatosis, thalassemia, and sickle cell disease and in healthy postmenopausal women. Recent studies have shown that iron overload is considered an independent risk factor for osteoporosis. Studies have demonstrated that iron overload could induce apoptosis and inhibit viability in osteoblasts. However, the underlying mec ...
DOI:: 10.1007/s12011-020-02508-x
: https://doi.org/10.1007/s12011-020-02508-x

98. Isoliquiritigenin-mediated miR-23a-3p inhibition activates PGC-1α to alleviate alcoholic liver injury

Author:: Lu Wang; Lina Kong; Shuai Xu; Xiaohui Wang; Kai Huang; Shuyuan Wang; Jingjing Wu; Changyuan Wang; Huijun Sun; Kexin Liu; Qiang Meng
Source:: Phytomedicine 2022 v.96 pp. 153845
ISSN:: 0944-7113
Subject:: Western blotting; bioinformatics; fatty acid metabolism; flavonoids; fluorescent antibody technique; hepatoprotective effect; histopathology; interleukin-6; licorice; lipids; liver; liver diseases; luciferase; quantitative polymerase chain reaction; reactive oxygen species; therapeutics
Abstract:: ... Alcoholic liver disease (ALD), one of the most prevalent forms of liver disease, has received wide attention worldwide. However, limited efficient and appropriate therapeutic agents were responded to ALD. Isoliquiritigenin (ISL), a flavonoid isolated from liquorice, possesses multiple pharmacological activities.The current study investigated the hepatoprotective effect of ISL against ALD and furth ...
DOI:: 10.1016/j.phymed.2021.153845
: https://doi.org/10.1016/j.phymed.2021.153845

99. Laminarin Attenuates ROS-Mediated Cell Migration and Invasiveness through Mitochondrial Dysfunction in Pancreatic Cancer Cells

Author:: Woonghee Lee; Gwonhwa Song; Hyocheol Bae
Source:: Antioxidants 2022 v.11 no.9 pp. -
ISSN:: 2076-3921
Subject:: Western blotting; adenocarcinoma; antineoplastic activity; apoptosis; calcium; cell movement; cell viability; colorectal neoplasms; drug therapy; flow cytometry; fluorouracil; hepatoma; lungs; membrane potential; metastasis; mitochondria; mitochondrial membrane; neoplasm cells; pancreatic neoplasms; reactive oxygen species; resection; toxicity testing
Abstract:: ... Pancreatic ductal adenocarcinoma (PDAC) is a notoriously aggressive type of cancer with a high metastasis rate. It is conventionally treated by surgical resection and neoadjuvant chemotherapy. However, continuous chemotherapy leads to relapse in most PDAC patients due to chemical resistance. Therefore, novel anticancer agents need to be identified and developed. The antitumor activities of laminar ...
DOI:: 10.3390/antiox11091714
: https://doi.org/10.3390/antiox11091714

100. Licochalcone A inhibits interferon-gamma-induced programmed death-ligand 1 in lung cancer cells

Author:: Luo-Wei Yuan; Xiao-Ming Jiang; Yu-Lian Xu; Mu-Yang Huang; Yu-Chi Chen; Wei-Bang Yu; Min-Xia Su; Zi-Han Ye; Xiuping Chen; Yitao Wang; Jin-Jian Lu
Source:: Phytomedicine 2021 v.80 pp. 153394
ISSN:: 0944-7113
Subject:: Glycyrrhiza inflata; T-lymphocytes; Western blotting; acetylcysteine; apoptosis; cell proliferation; coculture; flow cytometry; gene expression; humans; immunotherapy; interferon-gamma; luciferase; lung neoplasms; phosphorylation; protein degradation; protein synthesis; protein synthesis inhibitors; reactive oxygen species
Abstract:: ... Programmed death-ligand 1 (PD-L1), which can be induced by interferon-gamma (IFN-γ) in the tumor microenvironment, is a critical immune checkpoint in cancer immunotherapy. Natural products which reduce IFN-γ-induced PD-L1 might be exert immunotherapy effect. Licochalcone A (LCA), a natural compound derived from the root of Glycyrrhiza inflata Batalin. (Fabaceae), was found to interfere IFN-γ-induc ...
DOI:: 10.1016/j.phymed.2020.153394
: https://doi.org/10.1016/j.phymed.2020.153394

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1. 6-methoxydihydroavicine, the alkaloid extracted from Macleaya cordata (Willd.) R. Br. (Papaveraceae), triggers RIPK1/Caspase-dependent cell death in pancreatic cancer cells through the disruption of oxaloacetic acid metabolism and accumulation of reactive oxygen species

2. Activation of mitochondrial-associated apoptosis signaling pathway and inhibition of PI3K/Akt/mTOR signaling pathway by voacamine suppress breast cancer progression

3. Anemoside B4 prevents chronic obstructive pulmonary disease through alleviating cigarette smoke-induced inflammatory response and airway epithelial hyperplasia

4. Antagonistic Effect of Selenium on Fumonisin B1 Promotes Neutrophil Extracellular Traps Formation in Chicken Neutrophils

5. Black cardamom (Amomum subulatum Roxb.) fruit extracts exhibit apoptotic activity against lung cancer cells

6. Cedrus libani tar prompts reactive oxygen species toxicity and DNA damage in colon cancer cells

7. Clarifying winter clean heating importance: Insight chemical compositions and cytotoxicity exposure to primary and aged pollution emissions in China rural areas

8. Compound Tongluo Decoction inhibits endoplasmic reticulum stress-induced ferroptosis and promoted angiogenesis by activating the Sonic Hedgehog pathway in cerebral infarction

9. Dengzhan Xixin injection derived from a traditional Chinese herb Erigeron breviscapus ameliorates cerebral ischemia/reperfusion injury in rats via modulation of mitophagy and mitochondrial apoptosis

10. Development of a sandwich ELISA for the detection of chicken colony-stimulating factor 1

11. Di-(2-Ethylhexyl) Phthalate and Microplastics Induced Neuronal Apoptosis through the PI3K/AKT Pathway and Mitochondrial Dysfunction

12. Dihydroquercetin suppresses cigarette smoke induced ferroptosis in the pathogenesis of chronic obstructive pulmonary disease by activating Nrf2-mediated pathway

13. Ephedrae Herba polysaccharides inhibit the inflammation of ovalbumin induced asthma by regulating Th1/Th2 and Th17/Treg cell immune imbalance

14. Exploring the protective mechanism of baicalin in treatment of atherosclerosis using endothelial cells deregulation model and network pharmacology

15. Exposure to imidacloprid induce oxidative stress, mitochondrial dysfunction, inflammation, apoptosis and mitophagy via NF-kappaB/JNK pathway in grass carp hepatocytes

16. Fucosterol Isolated from Dietary Brown Alga Sargassum horneri Protects TNF-α/IFN-γ-Stimulated Human Dermal Fibroblasts Via Regulating Nrf2/HO-1 and NF-κB/MAPK Pathways

17. Germacranolide- and guaianolide-type sesquiterpenoids from Achillea alpina L. reduce insulin resistance in palmitic acid-treated HepG2 cells via inhibition of the NLRP3 inflammasome pathway

18. Ginsenoside-Rb1 prevents bone cartilage destruction through down-regulation of p-Akt, p-P38, and p-P65 signaling in rabbit

19. Glucagon-like peptide-1 receptor activation by liraglutide promotes breast cancer through NOX4/ROS/VEGF pathway

20. Hemp Seed Fermented by Aspergillus oryzae Attenuates Lipopolysaccharide-Stimulated Inflammatory Responses in N9 Microglial Cells

21. Hibiscus sabdariffa Extract Protects HaCaT Cells against Phenanthrene-Induced Toxicity through the Regulation of Constitutive Androstane Receptor/Pregnane X Receptor Pathway

22. Hydroxyproline alleviates 4-hydroxy-2-nonenal-induced DNA damage and apoptosis in porcine intestinal epithelial cells

23. Identification of mitochondria-related hub genes in sarcopenia and functional regulation of MFG-E8 on ROS-mediated mitochondrial dysfunction and cell cycle arrest

24. Identification of the NADPH Oxidase (Nox) Subtype and the Source of Superoxide Production in the Micturition Centre

25. Impact of the Plastein Reaction of Casein Hydrolysates in the Presence of Exogenous Amino Acids on Their Anti-Inflammatory Effect in the Lipopolysaccharide-Stimulated Macrophages

26. Influence of aryl hydrocarbon receptor and sulfotransferase 1A1 on bisphenol AF-induced clastogenesis in human hepatoma cells

27. Investigation of nickel sulfate‐induced cytotoxicity and underlying toxicological mechanisms in human umbilical vein endothelial cells through oxidative stress, inflammation, apoptosis, and MAPK signaling pathways

28. Isobavachalcone disrupts mitochondrial respiration and induces cytotoxicity through ROS accumulation and Akt suppression

29. Lithium intoxication induced pyroptosis via ROS/NF‐κB/NLRP3 inflammasome regulatory networks in kidney of mice

30. MEHP promotes liver fibrosis by down-regulating STAT5A in BRL-3A hepatocytes

31. Macrophage immunity promotion effect of polysaccharide LGP-1 from Guapian tea via PI3K/AKT and NF-κB signaling pathway

32. Mechanisms of RAW264.7 macrophages immunomodulation mediated by polysaccharide from mung bean skin based on RNA-seq analysis

33. Melatonin attenuates MPP+-induced apoptosis via heat shock protein in a Parkinson's disease model

34. Mitochondria-targeted triphenylphosphonium-based compounds inhibit FcεRI-dependent degranulation of mast cells by preventing mitochondrial dysfunction through Erk1/2

35. Nutritional properties of Europen eel (Anguilla anguilla) bone peptide-calcium and its apoptosis effect on Caco-2 cells

36. Oleic acid alleviates LPS-induced acute kidney injury by restraining inflammation and oxidative stress via the Ras/MAPKs/PPAR-γ signaling pathway

37. Oridonin attenuates low shear stress-induced endothelial cell dysfunction and oxidative stress by activating the nuclear factor erythroid 2-related factor 2 pathway

38. Oxidative stress and apoptosis in Asian honey bees (A. cerana) exposed to multiple pesticides in intensive agricultural landscape

39. Perillyl alcohol attenuates rheumatoid arthritis via regulating TLR4/NF-κB and Keap1/Nrf2 signaling pathways: A comprehensive study onin-vitro and in-vivo experimental models

40. Polyphenols in Ilex latifolia Thunb. inhibit human lung cancer cell line A549 by regulation of the PI3K-Akt signaling pathway

41. Pretreatment of hydroethanolic extract of Dillenia indica L. attenuates oleic acid induced NAFLD in HepG2 cells via modulating SIRT-1/p-LKB-1/AMPK, HMGCR & PPAR-α signaling pathways

42. Procalcitonin mediates vascular dysfunction in obesity

43. Protein sulfenylation contributes to oxidative burst-triggered responses during the interaction between Botrytis cinerea and Nicotiana benthamiana

44. Quercetin-3-Rutinoside alleviates radiation-induced lung inflammation and fibrosis via regulation of NF-κB/TGF-β1 signaling

45. Reactive oxygen species-dependent-NLRP3 inflammasome activation in human neutrophils induced by l-amino acid oxidase derived from Calloselasma rhodostoma venom

46. Safranal Treatment Induces Sirt1 Expression and Inhibits Endoplasmic Reticulum Stress in Mouse Chondrocytes and Alleviates Osteoarthritis Progression in a Mouse Model

47. Salidroside Ameliorates Radiation Damage by Reducing Mitochondrial Oxidative Stress in the Submandibular Gland

48. Salidroside, a phenyl ethanol glycoside from Rhodiola crenulata, orchestrates hypoxic mitochondrial dynamics homeostasis by stimulating Sirt1/p53/Drp1 signaling

49. Selenium Ameliorates S. aureus-Induced Inflammation in Bovine Mammary Epithelial Cells by Regulating ROS-Induced NLRP3 Inflammasome

50. Shensong Yangxin attenuates metabolic syndrome-induced atrial fibrillation via inhibition of ferroportin-mediated intracellular iron overload

51. Silibinin improves L-cell mass and function through an estrogen receptor-mediated antioxidative mechanism

52. Toxoplasma gondii activates NLRP12 inflammasome pathway in the BALB/c murine model

53. Upregulation of nuclear factor E2-related factor 2 (Nrf2) represses the replication of herpes simplex virus type 1

54. The anti-inflammatory activity by suppressing the TRAF6/MAPKs pathway of trishizukaol a from Sarcandra glabra

55. A high-value-added application of the stems of Rheum palmatum L. as a healthy food: the nutritional value, chemical composition, and anti-inflammatory and antioxidant activities

56. The natural compound from Garcinia bracteata mainly induces GSDME-mediated pyroptosis in esophageal cancer cells

57. The protective effect of quercetin on macrophage pyroptosis via TLR2/Myd88/NF-κB and ROS/AMPK pathway

58. The protective mechanism of Grx2 in ultraviolet-B (UVB)-induced cataract formation

59. A thioredoxin reductase 1 inhibitor pyrano [3,2-a] phenazine inhibits A549 cells proliferation and migration through the induction of reactive oxygen species production

60. 15-Hydroxy-8(17),13(E)-labdadiene-19-carboxylic acid (HLCA) inhibits proliferation and induces cell cycle arrest and apoptosis in ovarian cancer cells

61. Activation of PGC‐1α via isoliquiritigenin‐induced downregulation of miR‐138‐5p alleviates nonalcoholic fatty liver disease

62. Agrimoniin sensitizes pancreatic cancer to apoptosis through ROS-mediated energy metabolism dysfunction

63. Antioxidant Biodegradable Covalent Cyclodextrin Frameworks as Particulate Carriers for Inhalation Therapy against Acute Lung Injury

64. Antitumor Effects of a Sesquiterpene Derivative from Marine Sponge in Human Breast Cancer Cells

65. Antrodia camphorata extract (ACE)-induced apoptosis is associated with BMP4 expression and p53-dependent ROS generation in human colon cancer cells

66. Apigenin exerts chemopreventive effects on lung injury induced by SiO2 nanoparticles through the activation of Nrf2

67. Artemisia Leaf Extract protects against neuron toxicity by TRPML1 activation and promoting autophagy/mitophagy clearance in both in vitro and in vivo models of MPP+/MPTP-induced Parkinson's disease

68. Autophagy induced by H. pylori VacA regulated the survival mechanism of the SGC7901 human gastric cancer cell line

69. Betulinic Acid–Doxorubicin-Drug Combination Induced Apoptotic Death via ROS Stimulation in a Relapsed AML MOLM-13 Cell Model

70. Botanical formulation, TADIOS, alleviates lipopolysaccharide (LPS)-Induced acute lung injury in mice via modulation of the Nrf2-HO-1 signaling pathway