U.S. flag

An official website of the United States government

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Https

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

PubAg

Main content area

Search

194  Search Results

« Previous | 1 - 20 of 194 |
Number of results to display per page

Search Results

1. Structural elucidation, bio-inspired synthesis, and biological activities of cyclic diarylpropanes from Horsfieldia kingii

Author:
Rui Zhan; Dashan Li; Yuan-Lie Liu; Xiao-Yan Xie; Lei Chen; Li-Dong Shao; Wen-Jing Wang; Ye-Gao Chen
Source:
Tetrahedron 2020 v.76 no.40 pp. 131494
ISSN:
0040-4020
Subject:
X-ray diffraction; acetone; bioactive properties; bioassays; biomimetic synthesis; branches; chemical reactions; chemical structure; circular dichroism spectroscopy; crystallography; enzyme inhibition; inducible nitric oxide synthase; inhibitory concentration 50; leaves; lignans; nitric oxide; phytochemicals; spectral analysis
Abstract:
... Bioactivity-guided phytochemical investigation on 70% aqueous acetone extracts of the twigs and leaves of Horsfieldia kingii led to the isolation of two novel cyclic diarylpropanes (1 and 2) bearing a 2,3-dihydro-1H-indene core, one new diarylpropane (3), six known diarylpropanes (4–9), one flavanol (10), and seven lignans (11–17). Their structures were determined by extensive spectroscopic analys ...
DOI:
10.1016/j.tet.2020.131494

2. A new lignan glycoside from Astragalus yunnanensis

Author:
Ming-Zao Zhao; Yi Shen; Wei Xu; Ying-Zhi Chen; Chao-Jiang Xiao; Bei Jiang
Source:
Journal of Asian natural products research 2020 v.22 no.6 pp. 594-600
ISSN:
1477-2213
Subject:
Actinomyces viscosus; Astragalus; Candida albicans; Escherichia coli; Proteus vulgaris; Pseudomonas aeruginosa; Salmonella Typhi; Shigella dysenteriae; Staphylococcus aureus; Streptococcus mutans; antibacterial properties; antifungal properties; chemical structure; glycosides; lignans; methanol; nuclear magnetic resonance spectroscopy; plant extracts; roots; spectral analysis
Abstract:
... A new lignan glycoside, astrayunoside A (1), along with eight known compounds (2–9), were obtained from the methanol extract of roots of Astragalus yunnanensis. All the compounds were obtained from A. yunnanensis for the first time. Their structures were elucidated by extensive spectroscopic analysis (1D and 2D-NMR, MS, UV, CD, and IR). The weak antibacterial activities of the crude extracts of A. ...
DOI:
10.1080/10286020.2019.1607840

3. The Antioxidant Compounds from Urtica fissa Flowers

Author:
Mengyue Wang; Lili Wu; Hao Zhang; Dun Zhu Ci Ren; Tonghua Liu; Xiaobo Li
Source:
Chemistry of natural compounds 2019 v.55 no.5 pp. 839-842
ISSN:
0009-3130
Subject:
2,2-diphenyl-1-picrylhydrazyl; Urtica; antioxidants; chemical structure; flavonoids; flowers; lignans; median effective concentration; phenolic acids; spectral analysis
Abstract:
... Eleven compounds (1–11), including two new compounds (1, 2), were isolated from the antioxidant portion of the alcoholic extract of Urtica fissa flowers. Their chemical structures were elucidated from extensive spectroscopic analysis. The results of activity evaluation indicated that some compounds of phenolic acids (3, 4), flavonoids (7, 9, 10), and lignans (1, 6) possess significant activities o ...
DOI:
10.1007/s10600-019-02827-z

4. Chemical constituents from the leaves of Crataegus pinnatifida Bge

Author:
Wanchun Chu; Pinyi Gao; Lingzhi Li
Source:
Biochemical systematics and ecology 2019 v.86 pp. 103923
ISSN:
0305-1978
Subject:
Crataegus pinnatifida; carbon; chemical composition; chemical structure; chemotaxonomy; coumaric acids; flavonoids; leaves; lignans; nuclear magnetic resonance spectroscopy; spectral analysis; stable isotopes; triterpenoids
Abstract:
... The phytochemical investigations on the leaves of Crataegus pinnatifida led to the isolation of 20 compounds, including seven triterpenoids (1-7), three hydroxycinnamic acids (8-10), three lignans (11-13) and seven flavonoids (14-20). All chemical structures were established on the basis of NMR (1H NMR, 13C NMR) spectroscopic data. Meanwhile, compounds 3-12 are reported for the first time from Crat ...
DOI:
10.1016/j.bse.2019.103923

5. Chemical constituents isolated from the roots of Sanguisorba officinalis L. and their chemotaxonomic significance

Author:
Rongshen Wang; Jinfeng Sun; Chao Ye; Jiaming Wang; Tieqiang Zong; Wei Zhou; Gao Li
Source:
Biochemical systematics and ecology 2020 v.89 pp. 103999
ISSN:
0305-1978
Subject:
Sanguisorba officinalis; chemical composition; chemical structure; chemotaxonomy; flavonoids; glycosides; lignans; monoterpenoids; phenols; roots; spectral analysis; triterpenoids
Abstract:
... Phytochemical investigation of the roots of Sanguisorba officinalis L. led to the isolation of thirty-eight compounds, including seventeen triterpenoids (1–17), six monoterpenoid glycosides (18–23), six flavonoids (24–29), six phenols (30–35), two glycosides (36–37), and one lignan (38). The chemical structures of these compounds were elucidated on the basis of spectral data and by comparisons of ...
DOI:
10.1016/j.bse.2019.103999

6. New lignan glycosides from Cissus quadrangularis stems

Author:
Padam Kumar; Kapil Dev; Khushbu Sharma; Mahendra Sahai; Rakesh Maurya
Source:
Natural product research 2019 v.33 no.2 pp. 233-238
ISSN:
1478-6427
Subject:
Cissus quadrangularis; chemical constituents of plants; chemical structure; glycosides; lignans; mass spectrometry; nuclear magnetic resonance spectroscopy; spectral analysis; stems
Abstract:
... Phytochemical investigation of Cissus quadrangularis stems led to the isolation of one new phenolic glycoside (1) and two new lignan glycosides (7 & 8) along with twelve known compounds (2–6 & 9–15). Their chemical structures were determined on the basis of extensive spectroscopic analysis using 1D, 2D NMR, and mass spectrometric analysis. Among the known compounds, 4–6, 9 and 12 were isolated for ...
DOI:
10.1080/14786419.2018.1443099

7. Anti-HIV lignans from Justicia procumbens

Author:
Xin-Ya XU; Dong-Ying WANG; Chuen-Fai KU; Yang ZHAO; Han CHENG; Kang-Lun LIU; Li-Jun RONG; Hong-Jie ZHANG
Source:
Chinese journal of natural medicines 2019 v.17 no.12 pp. 945-952
ISSN:
1875-5364
Subject:
Human immunodeficiency virus 1; Justicia procumbens; Oriental traditional medicine; acetates; antiretroviral properties; chemical structure; cytotoxicity; inhibitory concentration 50; lignans; nuclear magnetic resonance spectroscopy; spectral analysis
Abstract:
... Twenty-one lignans including three new ones (1, 2 and 13) were isolated from Justicia procumbens. The chemical structures of the new lignans were determined by spectroscopic means including 1D and 2D NMR analysis. These compounds were evaluated for their cytotoxic and anti-HIV activities. The new secoisolariciresinol dimethyl ether acetate (13) exhibited anti-HIV-1 activity with an IC50 value of 5 ...
DOI:
10.1016/S1875-5364(19)30117-7

8. A New Neolignan Glucoside from the Stems of “Baekma” Cultivar, Chrysanthemum morifolium

Author:
Hyoung-Geun Kim; Hyun-Ji Oh; Jung-Hwan Ko; Sun-Woo Joo; Yeong-Geun Lee; Yun-Su Baek; Dae Young Lee; Nam-In Baek
Source:
Chemistry of natural compounds 2019 v.55 no.4 pp. 610-613
ISSN:
0009-3130
Subject:
Chrysanthemum morifolium; chemical structure; cultivars; glucosides; lignans; nuclear magnetic resonance spectroscopy; silica gel; spectral analysis; stems
Abstract:
... A new neolignan glucoside has been isolated from Chrysanthemum morifolium ‘Baekma’ cultivar through repeated silica gel and octadecyl silica gel (ODS) column chromatographies. On the basis of spectroscopic data including NMR, MS, and IR, the chemical structure of the new neolignan glucoside was determined to be (7S,8S)-7-O-[1′-(4′,5′-dihydroxy-3′-methoxyphenyl)propanol]guaiacylglycerol 4-O-β-D-glu ...
DOI:
10.1007/s10600-019-02760-1

9. Two new lignans from Horsfieldia kingii

Author:
Bo Liu; Shou-Zhen Du; Fang Kuang; Ying Liu; Xing-Jun Tian; Ye-Gao Chen; Rui Zhan
Source:
Natural product research 2019 v.33 no.1 pp. 95-100
ISSN:
1478-6427
Subject:
branches; chemical structure; cytotoxicity; humans; leaves; lignans; neoplasms; spectral analysis
Abstract:
... Two new dibenzylbutyrolactol lignans and three known dibenzylbutyrolactone lignans were isolated from the twigs and leaves of Horsfieldia kingii. Their structures were elucidated by spectroscopic analysis. Cytotoxicity evaluation of these compounds against five human tumour lines showed no inhibitory effects. ...
DOI:
10.1080/14786419.2018.1437429

10. Antiplasmodial Securinega alkaloids from Phyllanthus fraternus: Discovery of natural (+)-allonorsecurinine

Author:
Gustav Komlaga; Grégory Genta-Jouve; Sandrine Cojean; Rita A. Dickson; Merlin L.K. Mensah; Philippe M. Loiseau; Pierre Champy; Mehdi A. Beniddir
Source:
Tetrahedron letters 2017 pp. -
ISSN:
0040-4039
Subject:
Phyllanthus fraternus; Plasmodium falciparum; Securinega; alkaloids; antimalarials; antiparasitic properties; chemical reactions; chemical structure; inhibitory concentration 50; lignans; nuclear magnetic resonance spectroscopy; spectral analysis
Abstract:
... The chemical investigation of the antimalarial plant Phyllanthus fraternus G. L. Webster (Phyllanthaceae) resulted in the discovery of the Securinega alkaloid (+)-allonorsecurinine (1), previously reported as a synthetic compound, together with the known ent-norsecurinine (2), nirurine (3), bubbialine (4), epibubbialine (5) and the lignan phyllanthin (6). The structure and absolute configuration o ...
DOI:
10.1016/j.tetlet.2017.08.045

11. Enantiomeric 8-O-4′ type neolignans from red raspberry as potential inhibitors of β-amyloid aggregation

Author:
Le Zhou; Li-Li Lou; Wei Wang; Bin Lin; Jun-Ning Chen; Xiao-Bo Wang; Xiao-Xiao Huang; Shao-Jiang Song
Source:
Journal of functional foods 2017 v.37 pp. 322-329
ISSN:
1756-4646
Subject:
Alzheimer disease; Rubus idaeus; chemical composition; chemical structure; functional foods; lignans; neuroprotective effect; spectral analysis; stereochemistry
Abstract:
... Red raspberry (Rubus idaeus L.) is an edible fruit-producing species belonging to the Rosaceae family. In our search for potential agents for treating Alzheimer’s disease in this functional food, we decided to investigate the chemical constituents of red raspberry. Four pairs of enantiomeric 8-O-4′-type neolignans (1a/1b–4a/4b), including three new compounds (1a/1b and 2a), were identified from th ...
DOI:
10.1016/j.jff.2017.08.007

12. Neolignan and megastigmane glucosides from the aerial parts of Isodon japonicus with cell protective effects on BaP-induced cytotoxicity

Author:
Takahiro Matsumoto; Seikou Nakamura; Souichi Nakashima; Tomoe Ohta; Keiko Ogawa; Masashi Fukaya; Junko Tsukioka; Tomohiro Hasei; Tetsushi Watanabe; Hisashi Matsuda
Source:
Phytochemistry 2017 v.137 pp. 101-108
ISSN:
0031-9422
Subject:
aerial parts; chemical structure; cytotoxicity; glucosides; lignans; nuclear magnetic resonance spectroscopy; protective effect; spectral analysis; Japan
Abstract:
... Six neolignan glucosides, named isodonosides I–VI, and a megastigmane glucoside named isodonmegastigmane I, were isolated together with 15 known compounds from the methanolic extract of aerial parts of Isodon japonicus cultivated in Tokushima, Japan. The chemical structures of the compounds were elucidated based on their MS and NMR spectroscopic analysis. The absolute configurations of the neolign ...
DOI:
10.1016/j.phytochem.2017.02.007

13. Neolignan and monoterpene glycoside from the seeds of Pharbitis nil

Author:
Seoung Rak Lee; Eunjung Moon; Ki Hyun Kim
Source:
Phytochemistry letters 2017 v.20 pp. 98-101
ISSN:
1874-3900
Subject:
Ipomoea nil; anti-inflammatory activity; chemical structure; cytotoxicity; ethanol; glycosides; inhibitory concentration 50; lignans; lipopolysaccharides; mice; monoterpenoids; nitric oxide; nuclear magnetic resonance spectroscopy; seeds; spectral analysis
Abstract:
... Phytochemical investigation of an EtOH extract of Pharbitis nil seeds (Convolvulaceae) resulted in the isolation and identification of a new neolignan, 7R,8S-threo-dihydroxydehydrodiconiferyl alcohol (1), and a new monoterpene glycoside, (3Z,7S)-7-hydroxy-3,7-dimethyl-3,8-octadienyl-β-d-glucopyranoside (2), together with a known compound, ethyl α-l-arabinofuranoside (3). The chemical structures of ...
DOI:
10.1016/j.phytol.2017.04.019

14. Neuroprotective Lignans from the Fruits of Schisandra bicolor var. tuberculata

Author:
Liu Ye; Yu Heng-Yi; Wang Yan-Mei; Tian Tian; Wu Wen-Ming; Zhou Ming; Meng Xiang-Gao; Ruan Han-Li
Source:
Journal of natural products 2017 v.80 no.4 pp. 1117-1124
ISSN:
1520-6025
Subject:
Schisandra; X-ray diffraction; chemical structure; fruits; hydrogen peroxide; irradiation; lignans; models; neuroprotective effect; spectral analysis
Abstract:
... Nine new lignans (1–9) and ten known analogues (10–19) were isolated from the fruits of Schisandra bicolor var. tuberculata. The structures of compounds 1–9 were established on the basis of spectroscopic data analysis. The absolute configuration of compound 1 was determined by single-crystal X-ray diffraction analysis with Cu Kα irradiation techniques, and the absolute configurations of compounds ...
DOI:
10.1021/acs.jnatprod.7b00035

15. A New Insecticidal Lignan Glucoside from Galium verum

Author:
Jia Chen; Chun-Chao Zhao; Jian-Hua Shao; Ju-Di Fan; Xu-Hua Huang
Source:
Chemistry of natural compounds 2017 v.53 no.4 pp. 626-628
ISSN:
0009-3130
Subject:
Galium verum; Helicoverpa armigera; Scorpiones; chemical structure; glucosides; insecticidal properties; lignans; mortality; poisoning; scorpion venoms; spectral analysis; stomach; toxicity
Abstract:
... A new lignan glucoside, galiveroside A (1), and seven known compounds (2–8), were isolated from Galium verum L. The structure of 1 was elucidated on the basis of extensive spectroscopic analyses. Compound 1, at the concentration of 5 mg/mL, showed insecticide activity to 3 age cotton bollworm with a mortality of 16.3% through stomach poisoning. When combined with a recombinant scorpion toxin rLqh ...
DOI:
10.1007/s10600-017-2075-3

16. A New Lignan Glucoside from Cyclea racemosa

Author:
Jian-Hua Shao; Xue-Wei Zhang; Zi-Ling Dong; Si-Hui Li; Ben-Jie Miao; Ke-Zhi Cheng
Source:
Chemistry of natural compounds 2017 v.53 no.6 pp. 1025-1027
ISSN:
0009-3130
Subject:
Cyclea; chemical structure; glucosides; lignans; spectral analysis
Abstract:
... A new lignan glucoside 1, along with two known lignans (2, 3), was isolated from Cyclea racemosa Oliv. Its structure was elucidated as (+)-7′-methoxylariciresinol 4-O-β-D-glucopyranoside on the basis of extensive spectroscopic analyses. ...
DOI:
10.1007/s10600-017-2193-y

17. Coixlachryside A: A new lignan glycoside from the roots of Coix lachryma-jobi L. var. ma-yuen Stapf.

Author:
Seong Su Hong; Chun Whan Choi; Yun-Hyeok Choi; Joa Sub Oh
Source:
Phytochemistry letters 2016 v.17 pp. 152-157
ISSN:
1874-3900
Subject:
Coix lacryma-jobi; chemical structure; chromatography; circular dichroism spectroscopy; glycosides; lignans; nuclear magnetic resonance spectroscopy; roots; spectral analysis
Abstract:
... A new lignan glycoside, 1-[3,6-(4,4⿲-dihydroxy-3,3⿲-dimethoxy-δ-truxinyl)-β-fructofuranosyl]-α-glucopyranoside (1), named coixlachryside A, together with nine known simple phenolic compounds (3⿿11) were isolated from the roots of Coix lachryma-jobi var. ma-yuen using various chromatographic methods. Their chemical structures were determined based on the spectroscopic data interpretation, particula ...
DOI:
10.1016/j.phytol.2016.07.004

18. Lignans from a wild vegetable (Patrinina villosa) able to combat Alzheimer’s disease

Author:
Ming Bai; Guo-Dong Yao; Si-Fan Liu; Di Wang; Qing-Bo Liu; Xiao-Xiao Huang; Shao-Jiang Song
Source:
Journal of functional foods 2017 v.28 pp. 106-113
ISSN:
1756-4646
Subject:
Alzheimer disease; active ingredients; antioxidants; chemical structure; ethanol; functional foods; green leafy vegetables; lignans; molecular models; neuroprotective effect; salads; soups; spectral analysis; tetrahydrofuran; China; Japan; Korean Peninsula; North America
Abstract:
... Patrinina villosa Juss. is a delicious wild vegetable, which is widely distributed in China, Korea, Japan and North America. P. villosa, which smells fresh and is highly nutritious, can be made into a salad, used as greens and as a porridge and soup. Phytochemical investigation of the 70% EtOH extract showed the presence of two dibenzylbutyrolactone lignans (1–2), named Patrinians (A-B), along wit ...
DOI:
10.1016/j.jff.2016.10.024

19. A New Neolignan, Isoobovatol, from the Fruits of Magnolia obovata

Author:
Yun-Su Baek; Kyeong-Hwa Seo; Dae-Young Lee; Oh-Keun Kwon; Nam-In Baek
Source:
Chemistry of natural compounds 2016 v.52 no.6 pp. 986-988
ISSN:
0009-3130
Subject:
Magnolia obovata; chemical structure; ethyl acetate; fruits; lignans; spectral analysis
Abstract:
... A new neolignan was isolated from the EtOAc fraction obtained from Magnolia obovata fruits. The chemical structure of the new neolignan was determined to be 5,5′-diallyl-2,2′-dihydroxybiphenyl ether (1), named isoobovatol, based on physicochemical and spectroscopic data including FT-NMR and EI-MS. ...
DOI:
10.1007/s10600-016-1842-x

20. Two new lignan-iridoid glucoside diesters from the leaves of Vaccinium bracteatum and their relative and absolute configuration determination by DFT NMR and TDDFT-ECD calculation

Author:
Yong-Mei Ren; Chang-Qiang Ke; Attila Mándi; Tibor Kurtán; Chunping Tang; Sheng Yao; Yang Ye
Source:
Tetrahedron 2017 pp. -
ISSN:
0040-4020
Subject:
Vaccinium bracteatum; biochemical pathways; chemical reactions; chemical structure; circular dichroism spectroscopy; glucosides; iridoids; leaves; lignans; nuclear magnetic resonance spectroscopy; spectral analysis
Abstract:
... Two new lignan-iridoid glucoside diesters (2 and 3), together with their putative biosynthetic precursor 10-O-trans-caffeoyl-6α-hydroxyl-dihydromonotropein (1), were characterized from the leaves of Vaccinium bracteatum. Their planar structures and relative configuration were elucidated by spectroscopic measurements and DFT C NMR calculations, and their absolute configurations were determined by t ...
DOI:
10.1016/j.tet.2017.04.040