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You searched for: Subject spinal cord Remove constraint Subject: spinal cord Subject term biotin Remove constraint Subject term: biotin Subject term animal injuries Remove constraint Subject term: animal injuries
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1. Transplantation of tissue engineering neural network and formation of neuronal relay into the transected rat spinal cord

Author:
Bi-Qin Lai; Ming-Tian Che; Bao-Ling Du; Xiang Zeng; Yuan-Huan Ma; Bo Feng; Xue-Chen Qiu; Ke Zhang; Shu Liu; Hui-Yong Shen; Jin-Lang Wu; Eng-Ang Ling; Yuan-Shan Zeng
Source:
Biomaterials 2016 v.109 pp. 40-54
ISSN:
0142-9612
Subject:
Schwann cells; animal injuries; axons; biotin; cholera toxin; coculture; gelatin; motor neurons; nerve tissue; neural networks; rats; spinal cord; stem cells; synaptogenesis; tissue engineering; tissue transplantation
Abstract:
... Severe spinal cord injury (SCI) causes loss of neural connectivity and permanent functional deficits. Re-establishment of new neuronal relay circuits after SCI is therefore of paramount importance. The present study tested our hypothesis if co-culture of neurotrophin-3 (NT-3) gene-modified Schwann cells (SCs, NT-3-SCs) and TrkC (NT-3 receptor) gene-modified neural stem cells (NSCs, TrkC-NSCs) in a ...
DOI:
10.1016/j.biomaterials.2016.08.005

2. Improved stem cell therapy of spinal cord injury using GDNF-overexpressed bone marrow stem cells in a rat model

Author:
Mostafa Shahrezaie; Reyhaneh Nassiri Mansour; Bahare Nazari; Hadi Hassannia; Fatemeh Hosseini; Hossein Mahboudi; Mohamad Eftekhary; Mousa Kehtari; Arash Veshkini; Abbas Ahmadi Vasmehjani; Seyed Ehsan Enderami
Source:
Biologicals 2017 v.50 pp. 73-80
ISSN:
1045-1056
Subject:
animal injuries; animal models; animals; axons; biotin; bone marrow; gene therapy; genes; genetic engineering; spinal cord; stem cells
Abstract:
... The use of stem cell base therapy as an effective strategy for the treatment of spinal cord injury (SCI) is very promising. Although some strategy has been made to generate neural-like cells using bone marrow mesenchymal stem cells (BMSCs), the differentiation strategies are still inefficiently. For this purpose, we improved the therapeutic outcome with utilize both of N-neurotrophic factor derive ...
DOI:
10.1016/j.biologicals.2017.08.009

3. CD8 T cell-derived perforin aggravates secondary spinal cord injury through destroying the blood-spinal cord barrier

Author:
Zhaoxiang Liu; Hua Zhang; Hong Xia; Baocheng Wang; Renwen Zhang; Qun Zeng; Lingzhi Guo; Kui Shen; BaTa Wang; Yanheng Zhong; Zhizhong Li; Guodong Sun
Source:
Biochemical and biophysical research communications 2019 v.512 no.2 pp. 367-372
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; animal injuries; animal models; biotin; cerebrospinal fluid; cytokines; enzyme-linked immunosorbent assay; flow cytometry; humans; infectious diseases; inflammation; mice; permeability; spinal cord; staining
Abstract:
... Perforin plays an important role in autoimmune and infectious diseases, but its function in immune inflammatory responses after spinal cord injury (SCI) has received insufficient attention. The goal of this study is to determine the influence of perforin after spinal cord injury (SCI) on secondary inflammation. Compared recovery from SCI in perforin knockout (Prf1−/−) and wild-type(WT)mice, WT mic ...
DOI:
10.1016/j.bbrc.2019.03.002

4. Effects of Edaravone on Functional Recovery of a Rat Model with Spinal Cord Injury Through Induced Differentiation of Bone Marrow Mesenchymal Stem Cells into Neuron-Like Cells

Author:
Yumei Li; Laibing Liu; Zijiang Yu; Yan Yu; Baofei Sun; Chaolun Xiao; Shipeng Luo; Lin Li
Source:
Cellular reprogramming 2021 v.23 no.1 pp. 47-56
ISSN:
2152-4998
Subject:
animal injuries; animal models; biotin; bone marrow; cell transplantation; chromatin; density gradient centrifugation; dextran; edema; endoplasmic reticulum; eosin; fibroblast growth factor 2; fluorescence; head; immunohistochemistry; males; mitochondria; nerve tissue; phosphopyruvate hydratase; spinal cord; tail; transmission electron microscopy
Abstract:
... Edaravone can induce differentiation of bone marrow mesenchymal stem cells (BMSCs) into neuron-like cells and replace lost cells by transplanting neuron-like cells to repair spinal cord injury (SCI). In this study, BMSCs were derived from the bone marrow of male Wistar rats (4 weeks old) through density gradient centrifugation (1.073 g/mL), and the cell purity of BMSCs was up to 95%. The combined ...
DOI:
10.1089/cell.2020.0055