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- Author:
- Georgievaa, Liliya; Berkov, Strahil; Kondakova, Violeta; Bastida, Jaume; Viladomat, Francesc; Atanassov, Atanas; Codina, Carles
- Source:
- Zeitschrift für Naturforschung 2014 v.62 no.9-10 pp. 627-635
- ISSN:
- 1865-7125
- Subject:
- Alzheimer disease; Leucojum aestivum; acetylcholinesterase; bulbs; gas chromatography-mass spectrometry; lycorine; summer; Bulgaria
- Abstract:
- ... Leucojum aestivum (summer snowflake) is a plant species used for the extraction of galanthamine, an acetylcholinesterase inhibitor for the treatment of Alzheimer’s disease. Extracts from bulbs collected from 18 Bulgarian populations and from shoot-clumps obtained in vitro from 8 different populations showed variations in their alkaloid composition. Nineteen alkaloids were detected in the studied s ...
- DOI:
- 10.1515/znc-2007-9-1002
-
http://dx.doi.org/10.1515/znc-2007-9-1002
- Author:
- Ptak, Agata; Tahchy, Anna; Skrzypek, Edyta; Wójtowicz, Tomasz; Laurain-Mattar, Dominique
- Source:
- Open life sciences 2013 v.8 no.6 pp. 591-599
- ISSN:
- 2391-5412
- Subject:
- 2,4-D; Alzheimer disease; Leucojum aestivum; alkaloids; auxins; bulbs; callus; callus culture; dicamba; explants; growing media; phenolic compounds; picloram; polyethylene glycol; somatic embryogenesis
- Abstract:
- ... In vitro cultures of Leucojum aestivum are considered as an alternative for the production of galanthamine, which is used for the symptomatic treatment of Alzheimer’s disease. We studied the effects of auxins 2,4-dichlorophenoxyacetic acid (2,4-D), 4-amino-3,5,6-trichloropicolinic acid (picloram), 3,6-dichloro-o-anisic acid (dicamba) at concentrations of 25 and 50 µM on the induction of embryogeni ...
- DOI:
- 10.2478/s11535-013-0160-y
-
http://dx.doi.org/10.2478/s11535-013-0160-y
- Author:
- Berkov, Strahil; Georgieva, Lilija; Kondakova, Violeta; Viladomat, Francesc; Bastida, Jaume; Atanassov, Atanas; Codina, Carles
- Source:
- Biochemical systematics and ecology 2013 v.46 pp. 152-161
- ISSN:
- 0305-1978
- Subject:
- Alzheimer disease; Leucojum aestivum; acetylcholinesterase; biosynthesis; chemotypes; gas chromatography; lycorine; mass spectrometry; medicine; mountains; Balearic Islands; Bulgaria; Danube River
- Abstract:
- ... Leucojum aestivum, an industrial source of the acetylcholinesterase inhibitor galanthamine, shows a great chemodiversity in its alkaloid synthesis. Samples from various geographically distinct populations from Bulgaria and the Balearic Islands were studied by GC–MS. The alkaloid pattern of the plants of L. aestivum (subsp. pulchellum) from the Balearic Islands were dominated by crinine type compou ...
- DOI:
- 10.1016/j.bse.2012.10.002
-
https://dx.doi.org/10.1016/j.bse.2012.10.002
- Author:
- Berkov, Strahil; Bastida, Jaume; Viladomat, Francesc; Codina, Carles
- Source:
- Talanta 2011 v.83 no.5 pp. 1455-1465
- ISSN:
- 0039-9140
- Subject:
- Alzheimer disease; Leucojum aestivum; Narcissus; acetylcholinesterase; bulbs; gas chromatography-mass spectrometry; high performance liquid chromatography; leaves; metabolomics; methanol; nuclear magnetic resonance spectroscopy; pharmaceutical industry; principal component analysis; quality control; rapid methods; raw materials
- Abstract:
- ... Galanthamine, an acetylcholinesterase inhibitor marketed as a hydrobromide salt for the treatment of Alzheimer's disease, is obtained from some Amaryllidaceae plants. A new method was developed and validated for its quantification by GC–MS in different plant sources: bulbs and leaves from Narcissus confusus; bulbs from N. pseudonarcissus cv. Carlton; and leaves and in vitro cultures from L. aestiv ...
- DOI:
- 10.1016/j.talanta.2010.11.029
-
http://dx.doi.org/10.1016/j.talanta.2010.11.029
- Author:
- Diop, M. F.; Hehn, A.; Ptak, A.; Chrétien, F.; Doerper, S.; Gontier, E.; Bourgaud, F.; Henry, M.; Chapleur, Y.; Laurain-Mattar, D.
- Source:
- Phytochemistry reviews 2007 v.6 no.1 pp. 137-141
- ISSN:
- 1568-7767
- Subject:
- Alzheimer disease; Leucojum aestivum; Rhizobium rhizogenes; acetylcholinesterase; alkaloids; cell differentiation; growth regulators; metabolites; morphogenesis; roots; tissue culture
- Abstract:
- ... Galanthamine, an isoquinoline alkaloid acetylcholinesterase inhibitor, is an important agent used all around the world for the symptomatic treatment of senile dementia of the Alzheimer's type. The production of this metabolite and the availability of the plant are limited and prompted the search for an alternative way to obtain this valuable metabolite using in vitro cultures of Leucojum aestivum ...
- DOI:
- 10.1007/s11101-006-9043-z
-
http://dx.doi.org/10.1007/s11101-006-9043-z