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You searched for: Subject term Alzheimer disease Remove constraint Subject term: Alzheimer disease Subject term bulbs Remove constraint Subject term: bulbs
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1. Acetylcholinesterase inhibitory effects of the bulb of Ammocharis coranica (Amaryllidaceae) and its active constituent lycorine

Author:
I.L. Elisha; E.E. Elgorashi; A.A. Hussein; G. Duncan; J.N. Eloff
Source:
South African journal of botany 2013 v.85 pp. 44-47
ISSN:
0254-6299
Subject:
Alzheimer disease; Amaryllidaceae; acetylcholinesterase; bulbs; butanol; ethanol; ethyl acetate; fractionation; inhibitory concentration 50; lycorine; pathophysiology
Abstract:
... Ammocharis coranica (Ker-Gawl.) Herb. (Amaryllidaceae) is used in southern Africa for the treatment of mental illnesses. The ethanol extracts of the bulb of A. coranica and its total alkaloids rich fractions were screened for inhibition of acetylcholinesterase enzyme (AChE), which is implicated in the pathophysiology of Alzheimer's disease. The ethanolic extracts significantly inhibited AChE with ...
DOI:
10.1016/j.sajb.2012.11.008

2. Alkaloid Variability in Leucojum aestivum from Wild Populations

Author:
Liliya Georgievaa; Strahil Berkov; Violeta Kondakova; Jaume Bastida; Francesc Viladomat; Atanas Atanassov; Carles Codina
Source:
Zeitschrift für Naturforschung 2014 v.62 no.9-10 pp. 627-635
ISSN:
1865-7125
Subject:
Alzheimer disease; Leucojum aestivum; acetylcholinesterase; bulbs; gas chromatography-mass spectrometry; lycorine; summer; Bulgaria
Abstract:
... Leucojum aestivum (summer snowflake) is a plant species used for the extraction of galanthamine, an acetylcholinesterase inhibitor for the treatment of Alzheimer’s disease. Extracts from bulbs collected from 18 Bulgarian populations and from shoot-clumps obtained in vitro from 8 different populations showed variations in their alkaloid composition. Nineteen alkaloids were detected in the studied s ...
DOI:
10.1515/znc-2007-9-1002

3. Alkaloid profile and cholinesterase inhibition activity of five species of Amaryllidaceae family collected from Mérida state-Venezuela

Author:
Janne del C. Rojas-Vera; Alexis A. Buitrago-Díaz; Letícia M. Possamai; Luís F.S.M. Timmers; Luciana R. Tallini; Jaume Bastida
Source:
South African journal of botany 2021 v.136 pp. 126-136
ISSN:
0254-6299
Subject:
Alzheimer disease; Amaryllis belladonna; Crinum; Galanthus; Zephyranthes carinata; acetylcholinesterase; active sites; bulbs; cholinesterase; computer simulation; enzyme inhibition; gas chromatography-mass spectrometry; leaves; lycorine; temperate zones; therapeutics; Venezuela
Abstract:
... The Amaryllidaceae family is distributed mainly in tropical and subtropical areas but also in temperate zones. In Venezuela, there are 6 genera and 13 species distributed around the country. This family is characterized by its ability to biosynthesize alkaloids with an isoquinoline type structure. In addition, a number of investigations have revealed a variety of biological activities for these al ...
DOI:
10.1016/j.sajb.2020.03.001

4. Alkaloid profile in Pyrolirion albicans Herb. (Amaryllidaceae), a Peruvian endemic species

Author:
Hibert Huaylla; Olimpia Llalla; Laura Torras-Claveria; Jaume Bastida
Source:
South African journal of botany 2021 v.136 pp. 76-80
ISSN:
0254-6299
Subject:
Alzheimer disease; Amaryllidaceae; Neotropics; acetylcholinesterase; bioactive properties; bulbs; coasts; ecosystems; forests; gas chromatography; indigenous species; leaves; lycorine; mass spectrometry; temperate zones; Andes region; Peru
Abstract:
... The Amaryllidaceae family is widely distributed in different regions of the neotropics and temperate areas of the world. Species of the subfamily Amaryllidoideae are unique in producing the alkaloid galanthamine, which inhibits the action of acetylcholinesterase and is used for the treatment of Alzheimer's disease. In Perú, 15 genera and 68 species belonging to the Amaryllidoideae have been report ...
DOI:
10.1016/j.sajb.2020.03.016

5. Alkaloids of Amaryllidaceae as Inhibitors of Cholinesterases (AChEs and BChEs): An Integrated Bioguided Study

Author:
Natalie Cortes; Karina Sierra; Fernando Alzate; Edison H. Osorio; Edison Osorio
Source:
Phytochemical analysis 2018 v.29 no.2 pp. 217-227
ISSN:
0958-0344
Subject:
Alzheimer disease; Crinum; Eucharis; Torpedo californica; acetylcholinesterase; active sites; alkaloids; bioactive compounds; blood serum; bulbs; chemical constituents of plants; cholinesterase; densitometry; drugs; enzyme inhibition; enzyme inhibitors; gas chromatography-mass spectrometry; humans; inhibitory concentration 50; leaf extracts; therapeutics; thin layer chromatography
Abstract:
... INTRODUCTION: Enzymatic inhibition of acetylcholinesterase (AChE) is an essential therapeutic target for the treatment of Alzheimer's disease (AD) and AChE inhibitors are the first‐line drugs for it treatment. However, butyrylcholinesterase (BChE), contributes critically to cholinergic dysfunction associated with AD. Thus, the development of novel therapeutics may involve the inhibition of both ch ...
DOI:
10.1002/pca.2736

6. Alkaloids of Phaedranassa dubia (Kunth) J.F. Macbr. and Phaedranassa brevifolia Meerow (Amaryllidaceae) from Ecuador and its cholinesterase-inhibitory activity

Author:
Karen Acosta León; Alexandra Inca; Luciana R. Tallini; Edison H. Osorio; Jessica Robles; Jaume Bastida; Nora H. Oleas
Source:
South African journal of botany 2021 v.136 pp. 91-99
ISSN:
0254-6299
Subject:
Alzheimer disease; Amaryllidaceae; Gibbs free energy; acetylcholinesterase; active sites; alkaloids; bulbs; cholinesterase; computer simulation; gas chromatography; mass spectrometry; sampling; Ecuador
Abstract:
... Alzheimer's disease is considered the most common cause of dementia and, in an increasingly aging population worldwide, the quest for treatment is a priority. Amaryllidaceae alkaloids are of main interest because of their cholinesterase inhibition potential, which is the main palliative treatment available for this disease. We evaluated the alkaloidal profile and the in vitro inhibitory activity o ...
DOI:
10.1016/j.sajb.2020.09.007

7. Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease

Author:
Daniela Hulcová; Jana Maříková; Jan Korábečný; Anna Hošťálková; Daniel Jun; Jiří Kuneš; Jakub Chlebek; Lubomír Opletal; Angela De Simone; Lucie Nováková; Vincenza Andrisano; Aleš Růžička; Lucie Cahlíková
Source:
Phytochemistry 2019 v.165 pp. 112055
ISSN:
0031-9422
Subject:
Alzheimer disease; Narcissus pseudonarcissus; acetylcholinesterase; alkaloids; bulbs; chemical structure; cholinesterase; drugs; glycogen (starch) synthase; mass spectrometry; nuclear magnetic resonance spectroscopy; prolyl oligopeptidase; tau-protein kinase
Abstract:
... Twenty-one known Amaryllidaceae alkaloids of various structural types and one undescribed alkaloid, named narcimatuline, have been isolated from fresh bulbs of Narcissus pseudonarcissus L. cv. Dutch Master. The chemical structures were elucidated by combination of MS, HRMS, 1D and 2D NMR spectroscopic techniques, and by comparison with literature data. Narcimatuline amalgamates two basic scaffolds ...
DOI:
10.1016/j.phytochem.2019.112055

8. Chemo-profiling of some Turkish Galanthus L. (Amaryllidaceae) species and their anticholinesterase activity

Author:
Buket Bozkurt; Gulen Irem Kaya; Mustafa Ali Onur; Nehir Unver-Somer
Source:
South African journal of botany 2021 v.136 pp. 65-69
ISSN:
0254-6299
Subject:
Alzheimer disease; Galanthus; acetylcholinesterase; bioactive properties; bulbs; chemical composition; chemical structure; cholinesterase; cholinesterase inhibitors; indigenous species; isoquinoline alkaloids; lignans; ornamental value; plant extracts; research
Abstract:
... Amaryllidaceae family, consisting of economically important plants with ornamental value, is very well-known for its isoquinoline alkaloids with variable biological activities and chemical structures. Among these alkaloids, an effective acetylcholinesterase inhibitor galanthamine, is prescribed widely in the treatment of Alzheimer's disease. Plants of the Amaryllidaceae family are therefore, subje ...
DOI:
10.1016/j.sajb.2020.09.012

9. Comparison of anti-acetylcholinesterase activity of bulb and leaf extracts of Sternbergia candida Mathew & T. Baytop

Author:
M. Z. Haznedaroglu; G. Gokce
Source:
Acta biologica Hungarica 2014 v.65 no.4 pp. 396-404
ISSN:
0236-5383
Subject:
pathophysiology; leaf extracts; Alzheimer disease; lycorine; acetylcholinesterase; methanol; disease prevalence; metabolites; bulbs; cholinesterase inhibitors; cholinesterase; Sternbergia; chloroform; leaves
Abstract:
... Studies on Alzheimer’s disease have been highlighted due to increasing prevalence of this disease. Oldest hypothesis about the pathophysiology strengthens the research of cholinesterase inhibitors for treatment. Amaryllidaceae plants are well known for alkaloids showing cholinesterase inhibiting activity. Among them, Sternbergia species gained attention as a source of metabolites of these a ...
DOI:
10.1556/ABiol.65.2014.4.4

10. Daffodils as potential crops of galanthamine. Assessment of more than 100 ornamental varieties for their alkaloid content and acetylcholinesterase inhibitory activity

Author:
Laura Torras-Claveria; Strahil Berkov; Carles Codina; Francesc Viladomat; Jaume Bastida
Source:
Industrial crops and products 2013 v.43 pp. 237-244
ISSN:
0926-6690
Subject:
Alzheimer disease; Narcissus; acetylcholinesterase; bioactive properties; bulbs; crops; leaves; quantitative analysis
Abstract:
... Many plant varieties of Narcissus (Amaryllidaceae) are cultivated on a large scale for ornamental purposes but they are also known to contain galanthamine, a bioactive alkaloid used in antiacetylcholinesterasic therapy in Alzheimer's disease.More than 100 ornamental varieties of Narcissus, using leaves and bulbs separately, were screened for their galanthamine content as well as their acetylcholin ...
DOI:
10.1016/j.indcrop.2012.07.034

11. Development and validation of a GC–MS method for rapid determination of galanthamine in Leucojum aestivum and Narcissus ssp.: A metabolomic approach

Author:
Strahil Berkov; Jaume Bastida; Francesc Viladomat; Carles Codina
Source:
Talanta 2011 v.83 no.5 pp. 1455-1465
ISSN:
0039-9140
Subject:
Alzheimer disease; Leucojum aestivum; Narcissus; acetylcholinesterase; bulbs; gas chromatography-mass spectrometry; high performance liquid chromatography; leaves; metabolomics; methanol; nuclear magnetic resonance spectroscopy; pharmaceutical industry; principal component analysis; quality control; rapid methods; raw materials
Abstract:
... Galanthamine, an acetylcholinesterase inhibitor marketed as a hydrobromide salt for the treatment of Alzheimer's disease, is obtained from some Amaryllidaceae plants. A new method was developed and validated for its quantification by GC–MS in different plant sources: bulbs and leaves from Narcissus confusus; bulbs from N. pseudonarcissus cv. Carlton; and leaves and in vitro cultures from L. aestiv ...
DOI:
10.1016/j.talanta.2010.11.029

12. Effect of bulb age on alkaloid contents of narcissus pseudonarcissus bulbs

Author:
Muhammad Nadeem Akram; Robert Verpoorte; Barbora Pomahačová
Source:
South African journal of botany 2021 v.136 pp. 182-189
ISSN:
0254-6299
Subject:
Alzheimer disease; Narcissus pseudonarcissus; age; alkaloids; bioactive compounds; bulbs; extraction; fields; harvesting; home gardens; lead; medicine; metabolites; metabolomics; qualitative analysis; yields
Abstract:
... Narcissus is mostly grown for horticultural/decorative purposes in the fields and home gardens. Previously, galanthamine isolation (from the bulbs to produce medicine for the treatment of Alzheimer's disease) has been established as a novel use. Moreover, recent studies have also shown that Narcissus bulbs are also a source of several other interesting biologically active compounds and particularl ...
DOI:
10.1016/j.sajb.2020.07.034

13. Enhancement of alkaloid content (galanthamine and lycorine) and antioxidant activities (enzymatic and non-enzymatic) unders salt stress in summer snowflake (Leucojum aestivum L.)

Author:
Muhammed Tural Ates; Arzu Birinci Yildirim; Arzu Ucar Turker
Source:
South African journal of botany 2021 v.140 pp. 182-188
ISSN:
0254-6299
Subject:
Alzheimer disease; Leucojum aestivum; antimalarials; antioxidant activity; bioactive compounds; bulbs; catalase; free radicals; growth and development; lycorine; methanol; salt stress; salt tolerance; summer; superoxide dismutase; water content
Abstract:
... Summer snowflake (Leucojum aestivum L.) is a bulbous plant to the Amaryllidaceae family. L. aestivum is a Euro-Mediterranean region plant and is a well-known source of pharmacologically important alkaloids. Galanthamine is the major bioactive compound that is widely used in the treatment of neurological disorders, including Alzheimer's disease. Another alkaloid lycorine has antitumor, antimalarial ...
DOI:
10.1016/j.sajb.2021.04.016

14. Galanthamine production in tissue culture and metabolomic study on Amaryllidaceae alkaloids in Narcissus pseudonarcissus cv. Carlton

Author:
Aleya Ferdausi; Xianmin Chang; Anthony Hall; Meriel Jones
Source:
Industrial crops and products 2020 v.144 pp. 112058
ISSN:
0926-6690
Subject:
Alzheimer disease; Narcissus pseudonarcissus; agar; biochemical pathways; biosynthesis; bulbs; callus; cell culture; cholinesterase inhibitors; culture media; drugs; enzymes; explants; gas chromatography-mass spectrometry; leaves; lycorine; metabolomics; naphthaleneacetic acid; nuclear magnetic resonance spectroscopy; phenylalanine; shoots; tissue culture; tyrosine
Abstract:
... The Amaryllidaceae alkaloids e.g. galanthamine (Gal), lycorine and narciclasine are noted for their pharmaceutical properties. Gal is a long acting, selective, and competitive acetylcholinesterase inhibitor approved for the treatment of early to mid-stage Alzheimer's diseases. The biosynthesis of alkaloids by plants using in vitro systems has been considered as a tool for drug discovery and produc ...
DOI:
10.1016/j.indcrop.2019.112058

15. In vitro regeneration using twin scales for restoration of critically endangered aquatic plant Crinum malabaricum Lekhak & Yadav: a promising source of galanthamine

Author:
S. Priyadharshini; N. Kannan; M. Manokari; Mahipal S. Shekhawat
Source:
Plant cell, tissue, and organ culture 2020 v.141 no.3 pp. 593-604
ISSN:
0167-6857
Subject:
Alzheimer disease; Crinum; aquatic plants; benzyladenine; bulbs; cytokinins; drugs; endangered species; ex situ conservation; genetic stability; greenhouses; habitats; in vitro regeneration; indole acetic acid; indole butyric acid; meristems; microsatellite repeats; naphthaleneacetic acid; nutrients; rivers; roots; shoots; start codon; streams; survival rate
Abstract:
... This study intended to develop a significant in vitro regeneration protocol for sustainable propagation, conservation and re-establishment of critically endangered aquatic plant species Crinum malabaricum Lekhak & Yadav (Malabar river lily). This plant is the natural source of galanthamine, the drug to treat Alzheimer’s disease. We present a scientific understanding, emphasizing the use of twin sc ...
DOI:
10.1007/s11240-020-01818-1

16. Influence of auxins on somatic embryogenesis and alkaloid accumulation in Leucojum aestivum callus

Author:
Agata Ptak; Anna Tahchy; Edyta Skrzypek; Tomasz Wójtowicz; Dominique Laurain-Mattar
Source:
Open life sciences 2013 v.8 no.6 pp. 591-599
ISSN:
2391-5412
Subject:
2,4-D; Alzheimer disease; Leucojum aestivum; alkaloids; auxins; bulbs; callus; callus culture; dicamba; explants; growing media; phenolic compounds; picloram; polyethylene glycol; somatic embryogenesis
Abstract:
... In vitro cultures of Leucojum aestivum are considered as an alternative for the production of galanthamine, which is used for the symptomatic treatment of Alzheimer’s disease. We studied the effects of auxins 2,4-dichlorophenoxyacetic acid (2,4-D), 4-amino-3,5,6-trichloropicolinic acid (picloram), 3,6-dichloro-o-anisic acid (dicamba) at concentrations of 25 and 50 µM on the induction of embryogeni ...
DOI:
10.2478/s11535-013-0160-y

17. Isolation of narciprimine from Cyrtanthus contractus (Amaryllidaceae) and evaluation of its acetylcholinesterase inhibitory activity

Author:
Jerald J. Nair; Adeyemi O. Aremu; Johannes van Staden
Source:
Journal of ethnopharmacology 2011 v.137 no.3 pp. 1102-1106
ISSN:
0378-8741
Subject:
Alzheimer disease; Cyrtanthus; Lycoris; Narcissus; Zephyranthes; acetylcholinesterase; bulbs; chromatography; enzyme inhibition; enzyme inhibitors; lycorine; medicinal plants; nuclear magnetic resonance spectroscopy; traditional medicine; South Africa
Abstract:
... ETHNOPHARMACOLOGICAL RELEVANCE: Plants of the family Amaryllidaceae are used widely in traditional medicine in South Africa. Several of these, including representatives of the genus Cyrtanthus find use in the treatment of mental illness and age-related dementia. AIM OF THE STUDY: Based on the distribution of central nervous system-activating alkaloidal constituents within the genus Cyrtanthus, Cyr ...
DOI:
10.1016/j.jep.2011.07.028
PubMed:
21787856

18. Quantification of galantamine in Narcissus tazetta and Galanthus nivalis (Amaryllidaceae) populations growing wild in Iran

Author:
Majid Rahimi Khonakdari; Mohammad Hossein Mirjalili; Abbas Gholipour; Hassan Rezadoost; Mahdi Moridi Farimani
Source:
Plant genetic resources 2018 v.16 no.2 pp. 188-192
ISSN:
1479-263X
Subject:
Alzheimer disease; Galanthus nivalis; Narcissus tazetta; alkaloids; bulbs; high performance liquid chromatography; therapeutics; Iran
Abstract:
... Galantamine (GAL), a morphine-like alkaloid produced by some members of the Amaryllidaceae plant family, is a possible therapeutic agent in Alzheimer's disease because of its central cholinergic effects. GAL has been extracted from the plant sources or produced synthetically for pharmaceutical use. Limited supply of the natural source and high cost of synthetic production has led to a search for a ...
DOI:
10.1017/S1479262117000107

19. The application of HPLC with on-line coupled UV/MS-biochemical detection for isolation of an acetylcholinesterase inhibitor from Narcissus 'Sir Winston Churchill'

Author:
Ingkaninan, K.; Hazekamp, A.; Best, C.M. de.; Irth, H.; Tjaden, U.R.; Heijden, R. van der.; Greef, J. van der.; Verpoorte, R.
Source:
Journal of natural products 2000 v.63 no.6 pp. 803-806
ISSN:
0163-3864
Subject:
Narcissus; bulbs; alkaloids; spectral analysis; chemical structure; enzyme inhibitors; acetylcholinesterase; medicinal properties; Alzheimer disease; chemical constituents of plants
DOI:
10.1021/np9905719
PubMed:
10869205

20. A comprehensive study on narcissus tazetta subsp. tazetta L.: Chemo-profiling, isolation, anticholinesterase activity and molecular docking of amaryllidaceae alkaloids

Author:
Ç. Karakoyun; B. Bozkurt; G. Çoban; M. Masi; A. Cimmino; A. Evidente; N. Unver Somer
Source:
South African journal of botany 2020 v.130 pp. 148-154
ISSN:
0254-6299
Subject:
Alzheimer disease; Electrophorus electricus; Narcissus tazetta; acetylcholinesterase; active sites; aerial parts; alkaloids; bioactive properties; bulbs; cholinesterase; computer simulation; enzyme inhibition; gas chromatography-mass spectrometry; horses; monitoring; nuclear magnetic resonance spectroscopy; secondary metabolites; therapeutics
Abstract:
... Galanthamine, is the most known Amaryllidaceae alkaloid, which is currently being prescribed for the treatment of mild to moderate Alzheimer's disease (AD) due to its anti-acetylcholinesterase activity. Narcissus L., a genus belonging to the same family, has been subjected to intensive research owing to its broad alkaloidal range.The main objective of the present study was to evaluate Narcissus ta ...
DOI:
10.1016/j.sajb.2019.11.016