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1. Assessment of the anthelmintic activity and toxicity of metabolites of Dalea pogonathera (Fabaceae)
- Author:
- Victoria McPherson; Haley Wolhart; Lindsay Engels; Kiah Sullivan; Angel Coria; Teresa Bicchieri; Brendon Torrey; P. Clint Spiegel; Sam Danforth; Gil Belofsky; Blaise Dondji
- Source:
- Phytochemistry letters 2022 v.51 pp. 75-81
- ISSN:
- 1874-3900
- Subject:
- Ancylostoma ceylanicum; anthelmintics; chalcone; flavanones; hookworms; humans; metabolites; splenocytes; toxicity
- Abstract:
- ... Dalea pogonathera A. Gray was collected as part of a project to determine if metabolites of the genus Dalea have potential for the treatment of human hookworm disease, based on earlier findings of very active materials in D. ornata. We report here the isolation, characterization, and results of ex vivo bioassays of a new chalcone pogonatheridin A (1), and three new prenylated flavanones (3, 6, and ...
- DOI:
- 10.1016/j.phytol.2022.07.006
- https://doi.org/10.1016/j.phytol.2022.07.006
- Author:
- Tingting Zhuang; Asmaa M.I. Abuzeid; Junjing Hu; Shilan Zhu; Jinmiao Lu; Xue Zhou; Xiaoyu Chen; Guoqing Li
- Source:
- Parasitology international 2022 v.91 pp. 102633
- ISSN:
- 1383-5769
- Subject:
- Ancylostoma ceylanicum; Western blotting; antibodies; antibody formation; calreticulin; flow cytometry; fluorescent antibody technique; humans; immunization; immunogenicity; interleukin-10; interleukin-12; interleukin-13; interleukin-4; interleukin-5; interleukin-6; iron deficiency anemia; kidneys; malnutrition; parasitology; parasitoses; plasmids; spleen
- Abstract:
- ... Ancylostoma ceylanicum is a zoonotic soil-derived nematode that parasitizes human and animal intestines, causing malnutrition and iron-deficiency anemia. Calreticulin is a multifunctional protein involved in all stages of parasitic infection. Studies have found that parasites can secret calreticulin to regulate the host's immune response. To explore the immunogenicity of the eukaryotic expression ...
- DOI:
- 10.1016/j.parint.2022.102633
- https://doi.org/10.1016/j.parint.2022.102633
- Author:
- Thi Thuy Man Nguyen; Pierre Dorny; The Dung Dinh; Van Toan Nguyen; Hong Nhan Nguyen; Thi Giang Thanh Nguyen; Ha Thanh Dao; Veronique Dermauw
- Source:
- Current research in parasitology and vector-borne diseases 2022 v.2 pp. 100091
- ISSN:
- 2667-114X
- Subject:
- Ancylostoma caninum; Ancylostoma ceylanicum; Dipylidium caninum; Spirocerca lupi; Spirometra; Taenia hydatigena; Toxascaris leonina; Toxocara canis; Trichuris vulpis; cross-sectional studies; dogs; gastrointestinal system; mixed infection; parasitology; research; zoonoses; Vietnam
- Abstract:
- ... Helminths are among the most-commonly encountered disease-causing agents in dogs all over the world, including Vietnam. A cross-sectional survey was carried out between March and December 2019 in four dog slaughter-slabs in Yen Lap District, Phu Tho Province, northern Vietnam, aiming to reveal the occurrence of gastrointestinal helminths in dogs. Worms were collected from 350 dog samples and ident ...
- DOI:
- 10.1016/j.crpvbd.2022.100091
- https://doi.org/10.1016/j.crpvbd.2022.100091
- Author:
- Celi da Silva Medeiros; Luis Fernando Viana Furtado; Guilherme Silva Miranda; Vivian Jordania da Silva; Talita Rodrigues dos Santos; Élida Mara Leite Rabelo
- Source:
- Acta tropica 2022 v.233 pp. 106533
- ISSN:
- 0001-706X
- Subject:
- Ancylostoma ceylanicum; anthelmintics; benzimidazole; bioassays; codons; parasitoses; phenotype; ruminants; tubulin
- Abstract:
- ... Hookworms represent a serious problem for human and animal health in different parts of the world. One of the suggested control strategies for parasitosis caused by members of the Ancylostomatidae family is mass drug aministration with benzimidazole compounds. This strategy has been proven to lead to the establishment of resistant strains in several nematodes related to SNPs at codons 167, 198 and ...
- DOI:
- 10.1016/j.actatropica.2022.106533
- https://doi.org/10.1016/j.actatropica.2022.106533
- Author:
- Celi da Silva Medeiros; Lara Ribeiro de Almeida; Élida Mara Leite Rabelo; Luis Fernando Viana Furtado
- Source:
- Experimental parasitology 2022 pp. 108393
- ISSN:
- 0014-4894
- Subject:
- Ancylostoma ceylanicum; adults; albendazole; blood serum; cross resistance; eggs; females; genotype; hematocrit; hemoglobin; hookworms; host-parasite relationships; ivermectin; males; mebendazole; morphometry; parasitology; pathogenicity; phenotype
- Abstract:
- ... For some nematodes, alterations that leads to a resistance genotype may be accompanied by other modifications, causing changes in the biology of the parasite, although the exact mechanisms of this relationship are still not very clear. These alterations can have deleterious effects on their survival or even potentiate their pathogenicity. In this study a phenotypic characterization was carried out ...
- DOI:
- 10.1016/j.exppara.2022.108393
- https://doi.org/10.1016/j.exppara.2022.108393
- Author:
- Rahul Pratap Singh; Babul Chandra Roy; Nurjahan Begum; Md Hasanuzzaman Talukder
- Source:
- Veterinary Parasitology: Regional Studies and Reports 2022 v.30 pp. 100719
- ISSN:
- 2405-9390
- Subject:
- Ancylostoma caninum; Ancylostoma ceylanicum; Ancylostoma tubaeforme; DNA; dogs; fecal examination; genetic variation; hookworms; humans; microscopy; morphometry; polymerase chain reaction; veterinary parasitology; Bangladesh
- Abstract:
- ... Hookworms are the most common and voracious blood-sucking parasites of the small intestines of mammalian hosts such as dogs, cats, ruminants and humans. Canine hookworms are endemic in the Southeast Asian countries including Bangladesh. There is scarcity of information on the prevalence of hookworms of stray dogs in Bangladesh. The present study determined the prevalence of canine hookworms using ...
- DOI:
- 10.1016/j.vprsr.2022.100719
- https://doi.org/10.1016/j.vprsr.2022.100719
- Author:
- Khanh-Linh Bui; Thu-Huong Nguyen; Hieu Duc Duong; Viet-Linh Nguyen; Thi-Nhien Nguyen; Lan-Anh Le; Ha-My Cong; Khanh-Trang Tran; Duc-Vinh Le; Eiji Nagayasu; Nariaki Nonaka; Ayako Yoshida
- Source:
- Parasitology international 2021 v.84 pp. 102405
- ISSN:
- 1383-5769
- Subject:
- Ancylostoma ceylanicum; Necator americanus; adults; genes; hookworms; humans; intestines; parasitology; Vietnam
- Abstract:
- ... Ancylostoma ceylanicum is recognized as the only zoonotic hookworm species that is able to mature into adult stage in the human intestine. While human infections caused by this hookworm species have been reported from neighboring countries and this hookworm is prevalent in dogs in Vietnam, human infection has never been reported in Vietnam. The present study, therefore, aimed to identify human inf ...
- DOI:
- 10.1016/j.parint.2021.102405
- https://doi.org/10.1016/j.parint.2021.102405
- Author:
- Long He; Asmaa M. I. Abuzeid; Tingting Zhuang; Qi Zhao; Shilan Zhu; Xiaoyu Chen; Jumei Liu; Xiu Li; Guoqing Li
- Source:
- Parasitology research 2021 v.120 no.11 pp. 3805-3813
- ISSN:
- 0932-0113
- Subject:
- Ancylostoma ceylanicum; Enterococcus faecalis; Escherichia coli; antibacterial properties; coculture; dogs; erythrocytes; genetic vectors; hematophagy; hemolysis; hookworms; immunogenicity; interleukin-10; interleukin-12; interleukin-13; interleukin-4; parasitology; quantitative polymerase chain reaction; recombinant proteins; research; secretion; small intestine; vaccines
- Abstract:
- ... Ancylostoma ceylanicum is a common zoonotic nematode that inhabits the small intestine of humans, dogs, and cats. Saposin-like proteins (SLPs) have hemolytic and antibacterial activities and could be used as diagnostic or vaccine candidates. To explore the biological functions of Ancylostoma ceylanicum SLP (Ace-SLP-1), cDNA-encoding Ace-SLP-1 mature peptide was cloned into prokaryotic expression v ...
- DOI:
- 10.1007/s00436-021-07313-6
- https://doi.org/10.1007/s00436-021-07313-6
- Author:
- Jessica Yi Han Aw; Naomi E. Clarke; Helen J. Mayfield; Colleen L. Lau; Alice Richardson; Susana Vaz Nery
- Source:
- International journal for parasitology 2021 v.51 no.9 pp. 729-739
- ISSN:
- 0020-7519
- Subject:
- Ancylostoma ceylanicum; Ascaris; Bayesian theory; Necator americanus; at-risk population; climate; factor analysis; helminthiasis; hookworms; hygiene; intestines; model validation; parasitology; regression analysis; risk factors; sanitation; socioeconomic status; soil; vegetation; East Timor
- Abstract:
- ... Soil-transmitted helminths (STHs) are parasitic intestinal worms that infect almost a fifth of the global population. Sustainable control of STHs requires understanding the complex interaction of factors contributing to transmission. Identifying risk factors has mainly relied on logistic regression models where the underlying assumption of independence between variables is not always satisfied. Pr ...
- DOI:
- 10.1016/j.ijpara.2021.01.005
- https://doi.org/10.1016/j.ijpara.2021.01.005
- Author:
- Lat Lat Htun; Sandar Thu Rein; Shwe Yee Win; Nyein Chan Soe; Su Su Thein; Yadanar Khaing; Yu Nandi Thaw; Hla Myet Chel; Myint Myint Hmoon; Saw Bawm
- Source:
- Parasitology research 2021 v.120 no.10 pp. 3619-3624
- ISSN:
- 0932-0113
- Subject:
- Ancylostoma ceylanicum; Trichuris trichiura; Trichuris vulpis; cross-sectional studies; experimental design; gastrointestinal system; helminths; microscopy; parasitology; research; Myanmar
- Abstract:
- ... Dogs may serve as hosts for a variety of zoonotic or potentially zoonotic helminths, including Ancylostoma ceylanicum and Trichuris species. Cross-sectional study design was used to collect 210 faecal samples of dogs from Nay Pyi Taw area, Myanmar. According to microscopic examination, 180 samples (85.7%) were positive for eight species of gastrointestinal helminths. Among them, positive rates of ...
- DOI:
- 10.1007/s00436-021-07290-w
- https://doi.org/10.1007/s00436-021-07290-w
- Author:
- Rebecca J. Traub; Patsy A. Zendejas-Heredia; Luca Massetti; Vito Colella
- Source:
- International journal for parasitology 2021 v.51 no.13-14 pp. 1233-1241
- ISSN:
- 0020-7519
- Subject:
- Ancylostoma ceylanicum; cats; diagnostic techniques; dogs; enteritis; epidemiology; geographical distribution; hookworms; humans; morbidity; parasitology; Africa; Asia; South America
- Abstract:
- ... The early-to-mid 1900s was an era that marked the first published reports of clinical cases and experimental human infections that provided valuable evidence to inform our current knowledge on the zoonotic nature of the canid and felid hookworms. To this day, descriptions of the pathognomonic syndromes produced in humans by these early pioneers provide vital information on the putative geographica ...
- DOI:
- 10.1016/j.ijpara.2021.10.005
- https://doi.org/10.1016/j.ijpara.2021.10.005
- Author:
- Vijay Kumar Saxena; G.V. Vedamurthy; C.P. Swarnkar; Vinod Kadam; Suneel Kumar Onteru; Haseen Ahmad; Raghvendar Singh
- Source:
- Biochimie 2021 v.187 pp. 110-120
- ISSN:
- 0300-9084
- Subject:
- Ancylostoma ceylanicum; Haemonchus contortus; Oesophagostomum dentatum; Western blotting; adults; affinity chromatography; antibodies; biochemical pathways; cysteine; cysteine synthase; enzyme kinetics; gastrointestinal nematodes; genes; larvae; recombinant proteins; serine; sheep
- Abstract:
- ... Haemonchus contortus, commonly known as Barber's pole worm, is an economically important gastrointestinal nematode of sheep and goats especially in tropical and sub-tropical regions of the world. Cysteine synthesis is a very important metabolic pathway for the parasite, however the functional aspects of cysteine synthesis in parasite are largely unknown. The key question which we have investigated ...
- DOI:
- 10.1016/j.biochi.2021.05.014
- https://doi.org/10.1016/j.biochi.2021.05.014
- Author:
- Doolyawat Kladkempetch; Sahatchai Tangtrongsup; Saruda Tiwananthagorn
- Source:
- Animals 2020 v.10 no.11 pp. -
- ISSN:
- 2076-2615
- Subject:
- Ancylostoma ceylanicum; ancestry; deworming; dogs; gene flow; genes; genetic variation; haplotypes; hookworms; microscopy; risk reduction; zoonoses; Thailand
- Abstract:
- ... Ancylostoma ceylanicum is a zoonotic helminth that is commonly found in domestic dogs and cats throughout Asia but is largely neglected in many countries. This study aimed to confirm the species of hookworm in dogs and soil environments and investigate the evolutionary analyses of A. ceylanicum among Thai and Asian populations. In a total of 299 dog fecal samples and 212 soil samples from 53 templ ...
- DOI:
- 10.3390/ani10112154
- https://doi.org/10.3390/ani10112154
14. Characterisation and structural analysis of glyoxylate cycle enzymes of Teladorsagia circumcincta
- Author:
- Saleh Umair; Charlotte Bouchet; Nikola Palevich; Heather V. Simpson
- Source:
- Molecular and biochemical parasitology 2020 v.240 pp. 111335
- ISSN:
- 0166-6851
- Subject:
- Ancylostoma ceylanicum; Escherichia coli; Haemonchus contortus; Haemonchus placei; Teladorsagia circumcincta; amino acid sequences; blood serum; glyoxylate cycle; isocitrate lyase; malate synthase; pH; parasitology; polyacrylamide gel electrophoresis; saliva; sheep
- Abstract:
- ... A 1332 bp full length cDNA encoding Teladorsagia circumcincta isocitrate lyase (TciICL) and a 1575 bp full length cDNA encoding T. circumcincta malate synthase (TciMS) were cloned, expressed in Escherichia coli and the recombinant proteins purified. The predicted TciICL protein of 444 amino acids was present as a single band of about 52 kDa on SDS-PAGE and the recombinant TciMS of 525 amino acids ...
- DOI:
- 10.1016/j.molbiopara.2020.111335
- https://doi.org/10.1016/j.molbiopara.2020.111335
- Author:
- Yue Huang; Asmaa M.I. Abuzeid; Tingting Zhuang; Shilan Zhu; Long He; Yunqiu Liu; Qi Zhao; Xiaoyu Chen; Guoqing Li
- Source:
- Parasitology research 2020 v.119 no.6 pp. 1777-1784
- ISSN:
- 0932-0113
- Subject:
- Ancylostoma ceylanicum; adhesion; cell proliferation; dogs; hookworms; interleukin-10; interleukin-13; iron deficiency anemia; malnutrition; mononuclear leukocytes; parasitology; platelet aggregation; recombinant proteins; research
- Abstract:
- ... Ancylostoma ceylanicum is a zoonotic parasitic nematode that can cause iron-deficiency anemia and malnutrition in humans. A. ceylanicum hookworm platelet inhibitor (Ace-HPI) can inhibit platelet aggregation in the host to facilitate blood sucking, but whether it possesses platelet adhesion inhibitory activity or immunomodulatory role is yet unknown. To explore the effect of Ace-HPI on platelet adh ...
- DOI:
- 10.1007/s00436-020-06678-4
- https://doi.org/10.1007/s00436-020-06678-4
- Author:
- Martin Knaus; Piyanan Taweethavonsawat; Tara Cheesman; Martin Visser; Steffen Rehbein
- Source:
- Veterinary parasitology: X 2020 v.277 pp. 100025
- ISSN:
- 0304-4017
- Subject:
- Ancylostoma ceylanicum; adults; cats; dogs; eggs; eprinomectin; feces; fipronil; hookworms; humans; larvae; methoprene; necropsy; oral administration; parasitism; praziquantel; South America; South East Asia; Southern Africa
- Abstract:
- ... Ancylostomaceylanicum hookworms parasitize dogs and cats in subtropical and tropical South East Asia and Pacific region, the Arab Peninsula, southern Africa and South America but cause patent infections in humans too.To evaluate the efficacy of Broadline®, a combination product comprising eprinomectin, fipronil, (S)-methoprene and praziquantel, against developing fourth-larval stage (L4) and adult ...
- DOI:
- 10.1016/j.vpoa.2020.100025
- https://doi.org/10.1016/j.vpoa.2020.100025
- Author:
- Yue Huang; Asmaa M.I. Abuzeid; Yunqiu Liu; Long He; Qi Zhao; Xinxin Yan; Jianxiong Hang; Rongkun Ran; Yongxiang Sun; Xiu Li; Jumei Liu; Guoqing Li
- Source:
- Infection, genetics, and evolution 2020 v.77 pp. 104102
- ISSN:
- 1567-1348
- Subject:
- Ancylostoma caninum; Ancylostoma ceylanicum; Escherichia; Western blotting; adults; blood serum; drug development; esophagus; fluorescent antibody technique; gene expression regulation; genes; hematophagy; hemorrhage; hookworms; infection; intestines; iron deficiency anemia; larvae; nucleotide sequences; pathogenesis; phylogeny; platelet aggregation; quantitative polymerase chain reaction; recombinant proteins; sequence homology; vaccines
- Abstract:
- ... Ancylostoma ceylanicum is a zoonotic hookworm, which mainly causes iron deficiency anemia (IDA) in humans and animals. Hookworm platelet inhibitor (HPI) has been isolated from adult Ancylostoma caninum and linked to the pathogenesis of hookworm associated intestinal hemorrhage and IDA. However, there is no available data about HPI from A. ceylanicum. To study the molecular characteristics of A. ce ...
- DOI:
- 10.1016/j.meegid.2019.104102
- https://doi.org/10.1016/j.meegid.2019.104102
- Author:
- Gil Belofsky; Lindsay Engels; Victoria McPherson; Katherine Nash; Kiah Sullivan; Brendon Torrey; Cassandra Ripley; Angel Coria; Teresa Bicchieri; Blaise Dondji
- Source:
- Phytochemistry 2020 v.177 pp. 112423
- ISSN:
- 0031-9422
- Subject:
- Ancylostoma ceylanicum; Dalea; adults; anthelmintics; assays; chalcone; hookworms; humans; mass spectrometry; metabolites; nuclear magnetic resonance spectroscopy; roots; splenocytes; stereoisomers; toxicity
- Abstract:
- ... The US Southwest plant Dalea parryi (Fabaceae) was investigated as part of an ongoing study of the potential of plant compounds for anthelmintic activity to the human pathogenic hookworm Ancylostoma ceylanicum. This has resulted in the isolation of three previously undescribed isoflavonoid metabolites, denoted parryans A-C, a chalcone, six pterocarpans, and three known compounds from the roots of ...
- DOI:
- 10.1016/j.phytochem.2020.112423
- https://doi.org/10.1016/j.phytochem.2020.112423
- Author:
- Sebastiao Rodrigo Ferreira; Alan Rodrigues T. Machado; Luís Fernando Furtado; Jose Hugo de S. Gomes; Raquel M. de Almeida; Thiago de Oliveira Mendes; Valentina N. Maciel; Fernando Sergio Barbosa; Lorendane M. Carvalho; Lilian Lacerda Bueno; Daniella Castanheira Bartholomeu; Jackson Victor de Araújo; Elida M. L. Rabelo; Rodrigo Maia de Pádua; Lucia Pinheiro Santos Pimenta; Ricardo Toshio Fujiwara
- Source:
- Parasites & vectors 2020 v.13 no.1 pp. 527
- ISSN:
- 1756-3305
- Subject:
- Ancylostoma ceylanicum; Ascaris suum; Caenorhabditis elegans; Pochonia chlamydosporia; albendazole; ethyl acetate; food availability; human health; ivermectin; ketamine; livestock; nematicidal properties; nematophagous fungi; parasites
- Abstract:
- ... BACKGROUND: Infection by nematodes is a problem for human health, livestock, and agriculture, as it causes deficits in host health, increases production costs, and incurs a reduced food supply. The control of these parasites is usually done using anthelmintics, which, in most cases, have not been fully effective. Therefore, the search for new molecules with anthelmintic potential is necessary. MET ...
- DOI:
- 10.1186/s13071-020-04402-w
- https://doi.org/10.1186/s13071-020-04402-w
- Author:
- J.X. Hang; L. He; A.M.I. Abuzeid; Y. Huang; Y.Q. Liu; X.X. Yan; Q. Zhao; X. Li; J.M. Liu; G.Q. Li
- Source:
- Journal of helminthology v.94 pp. e118
- ISSN:
- 1475-2697
- Subject:
- Ancylostoma caninum; Ancylostoma ceylanicum; Escherichia coli; Necator americanus; adults; antibody formation; blood serum; complementary DNA; enzyme-linked immunosorbent assay; fluorescent antibody technique; glutathione transferase; hematophagy; hookworms; immunoglobulin G; intestines; mice; muscles; nucleotide sequences; phylogeny; polyclonal antibodies; recombinant proteins; reverse transcriptase polymerase chain reaction; vaccine development
- Abstract:
- ... Glutathione S-transferases (GSTs) are a detoxifying enzyme family that is essential for parasite blood-feeding and survival, and represent potential targets for hookworm vaccine development. Multiple GST-encoding complementary DNAs (cDNAs) have been cloned from Ancylostoma caninum and Necator americanus, but there are no reports about the cloning of this enzyme from Ancylostoma ceylanicum, the ani ...
- DOI:
- 10.1017/S0022149X20000012
- https://doi.org/10.1017/S0022149X20000012