An official website of the United States government
Here’s how you know
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
European Union; adsorption; animal-based foods; antibiotics; antibodies; biosensors; chicken meat; chickens; cost effectiveness; detection limit; enrofloxacin; fluorescence; food safety; food supply chain; human health; maximum residue limits; rapid methods; raw chicken meat; wavelengths; China
Abstract:
... HighlightsA nanobiosensor was developed for rapid detection of enrofloxacin residues in chicken meat.5-Sulfosalicylic acid was adopted in a facile method for pretreatment of chicken meat samples.The detection limit of 14.1 µg kg-1 was below the maximum residue limit for chicken meat.The total detection time from sample pretreatment to result report was less than 1.5 h.Abstract. Antibiotic residues ...
... The adsorption behaviors of ciprofloxacin (CIP), a fluoroquinolone antibiotic, onto goethite (Gt) in the presence of silver and titanium dioxide nanoparticles (AgNPs and TiO₂NPs) were investigated. Results showed that CIP adsorption kinetics in Gt with or without NPs both followed the pseudo-second-order kinetic model. The presence of AgNPs or TiO₂NPs inhibited the adsorption of CIP by Gt. The amo ...
... To observe the clinical efficacy and safety of oral administration of the traditional Chinese herb rhubarb to treat acute exacerbation of chronic obstructive pulmonary disease (AECOPD).This was a multicenter randomized double-blinded placebo controlled study that took place in 7 provinces of China that enrolled 244 patients (aged 18–80 years) who had acute exacerbation of COPD with the traditional ...
functional foods; high density lipoprotein; blood lipids; drug therapy; Helicobacter pylori; antibiotics; humans; biomarkers; long term effects; health status; garlic; cholesterol; low density lipoprotein; protein intake; vitamin-mineral supplements; randomized clinical trials; bacterial infections; China
Abstract:
... BACKGROUND: Little is known about the long-term effects of garlic or micronutrient supplementation on total, HDL, and LDL cholesterol in disease-free persons. OBJECTIVE: We aimed to assess the effects of long-term supplementation with garlic and micronutrients and of short-term amoxicillin and omeprazole treatment on serum total, HDL, and LDL cholesterol in a rural Chinese population. DESIGN: We c ...
benzylpenicillin; beta-lactamase; dairy industry; detection limit; high performance liquid chromatography; instrumentation; milk; pasteurization; statistical analysis; China
Abstract:
... To circumvent the strictly regulated limits of antibiotics in milk, illegal addition of β-lactamase to lower the antibiotic levels in milk has been reported recently in China. Herein, we describe a fast, sensitive, and robust HPLC-UV method for the determination of β-lactamase activity in milk, based on an indirect quantification strategy. The test milk sample was mixed with a known amount of peni ...
Escherichia coli; European Union; HACCP; Salmonella Enteritidis; antibiotic resistance; antibiotics; farms; good agricultural practices; good manufacturing practices; hygiene; issues and policy; monitoring; multiple drug resistance; plate count; poultry; poultry meat; poultry production; raw meat; retail marketing; risk assessment; serotypes; China; Indiana; Japan; Kentucky; Korean Peninsula
Abstract:
... The objective of this study was to investigate the relationship between hygienic indicators and Salmonella contamination in poultry meat from retail markets in China. From July 2016 to December 2016, a total of 2331 samples were collected from different outlets in 20 provinces of China. All the samples were examined for aerobic plate counts, Escherichia coli and Salmonella. The Salmonella serotypi ...
agricultural runoff; antibiotic resistance; antibiotics; excreta; human population; microbial ecology; minimum inhibitory concentration; mutation; sediments; selection pressure; surveys; China
Abstract:
... Antibiotics are poorly metabolized, and can enter the environment via human waste streams, agricultural run-off and pharmaceutical effluent. We consequently expect to see a concentration gradient of antibiotic compounds radiating from areas of human population. Such antibiotics should be thought of as pollutants, as they can accumulate, and have biological effects. These antibiotic pollutants can ...
animal health; antibiotic resistance; antibiotics; aquaculture; aquaculture industry; environment; human health; humans; issues and policy; livestock; pollution; research and development; systematic review; China
Abstract:
... China is one of the largest producers and consumers of antibiotics, and China is a larger producer of livestock farming and aquaculture in the world. The livestock farming and aquaculture industry is a major area of antibiotic misuse, which has caused serious antibiotic residues and environment pollution. The antibiotic residues exceeding the standard may lead to antibiotic resistances in animals ...
adsorption; antibiotics; aquatic environment; lakes; models; pH; sediments; sorption isotherms; sulfadiazine; sulfadimethoxine; sulfamethoxazole; water solubility; China
Abstract:
... Sulfonamides (SAs) are one class of the most widely used antibiotics around the world. Their fate and transport in the aquatic environment is of great concern. In this study, adsorption of four SAs—sulfadiazine (SD), sulfamethoxazole (SMZ), sulfadimethoxine (SDM) and sulfamethazine (SM2)—in single-solute and multi-solute systems on sediments of Dianchi (DC) Lake and Taihu (TH) Lake, China was inve ...
... A disease with white spots in internal organs of Nile tilapia occurred in Zhanjiang, southern China. Multiple, white nodules, 0.8–2.2 mm in diameter, were scattered throughout the liver, spleen and kidney of diseased fish. Signs of nodules reproduced after artificial infection with the isolated strain. Isolated bacteria were Gram‐negative, facultative anaerobic, motile, short rod‐shaped, with a le ...
... Clinically relevant antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) in bioaerosols have become a greater threat to public health. However, few reports have shown that ARB and ARGs were found in the atmosphere. High-throughput sequencing applied to environmental sciences has enhanced the exploration of microbial populations in atmospheric samples. Thus, five nosocomial bi ...
2,2-diphenyl-1-picrylhydrazyl; anti-infective properties; antibiotics; antioxidant activity; antioxidants; chloroform; colorimetry; ethyl acetate; fatty acids; gas chromatography-mass spectrometry; herbs; in vitro studies; methanol; microorganisms; petroleum; China
Abstract:
... Recineckea carnea and Tupistra chinensis collected from the Guizhou province (China) were evaluated in this study. Petroleum ether fractions from the two herbs were subjected to gas chromatography–mass spectrometry analysis; 10 species, which were fatty acids or aliphatic esters, were identified. The antimicrobial activities of a variety of extracts were evaluated against four microorganisms. The ...
Escherichia coli; Pangasius; Staphylococcus aureus; Vibrio; animal pathogens; antibiotics; farming systems; fish fillets; frozen fish; gentian violet; hake; liquid chromatography; malachite green; microbiological quality; monitoring; plate count; public health; tandem mass spectrometry; whole milk; Argentina; China; United Arab Emirates; United States; Vietnam
Abstract:
... A rapid and sensitive liquid chromatography‐tandem mass spectrometry (LC‐MS/MS) method was validated and used to quantify crystal violet (CV), leucocrystal violet (LCV), malachite green (MG), leucomalachite green (LMG), and brilliant green (BG) residues in frozen fish (121 samples) from various countries, in order to detect the use of prohibited antibiotic dyes in fish for human consumption. The m ...
antibiotic resistance; antibiotics; bovine mastitis; dairy cows; genetic variation; genotype; methicillin-resistant Staphylococcus aureus; milk; minimum inhibitory concentration; monitoring; multilocus sequence typing; multiple drug resistance; phenotype; public health; staphylococcal protein A; China
Abstract:
... Background: Diseases caused by livestock-associated methicillin-resistant Staphylococcus aureus (MRSA) are an important global public health concern, and MRSA is increasingly being isolated in bovine milk. However, information on the genotype and antimicrobial resistance of MRSA in bovine milk in Xinjiang is limited. The objective of this study was to determine the antimicrobial-susceptible phenot ...
antibiotic resistance; antibiotics; bioactive properties; environment; integrases; China
Abstract:
... The extensive pollution of antibiotics and antibiotic resistance genes (ARGs) in drinking water has aroused worldwide concern. Successive monitoring of these pollutants has noteworthy significance for drinking water safety. Accordingly, this study conducted successive monitoring of antibiotics and ARGs from 2015 to 2017 in a drinking water source in East China. The total antibiotic concentration r ...
Aeromonas hydrophila; Oriental traditional medicine; Potentilla chinensis; alkaline phosphatase; antibiotics; aquaculture; membrane permeability; minimum inhibitory concentration; mortality; nuclear magnetic resonance spectroscopy; pathogens; phosphoglucomutase; polyacrylamide gel electrophoresis; porins; pyruvate dehydrogenase (lipoamide); China
Abstract:
... Potentilla chinesis Ser. (Wei Ling Cai) was a food for humans and animals in China, as well as a traditional Chinese herb recorded in “ZhonghuaBencao”. Aeromonas hydrophila NJ-35 (NJ-35) was a bacterial pathogen associated with high mortality rate in aquaculture. The purpose of the present work was to isolate and identify the anti-bacterial components against the NJ-35 from the extract of Wei Ling ...
... The present study aims to investigate the probiotic properties of novel strains of lactic acid bacteria isolated from traditional artisanal milk cheese from Northeast China and to explore their antibacterial activity against enteropathogenic bacteria. Of the 321 isolates, 86 exhibited survival in low pH, resistance to pancreatin, and tolerance to bile salts; of these, 12 inhibited the growth of mo ...
... Luo Han Guo (LHG) fruits (Siraitia grosvenorii Swingle) have been used as traditional medicine in China for centuries to treat sore throats and coughs. However, LHG leaves are seldom used and minimal scientific information is available on them. In our recent study on the leaves of S. grosvenorii, the bioactive compounds β-amyrin (2), aloe emodin (5), aloe-emodin acetate (6), 5α,8α-epidioxy-24(R)-m ...
antibiotics; average daily intake; bioaccumulation; biotransformation; fluoroquinolones; food webs; human health; humans; hydrophobicity; invertebrates; macrolides; pH; pelagic fish; pollution; risk; risk management; trimethoprim; China
Abstract:
... Little information is available about the bioaccumulation and biomagnification of antibiotics in marine food webs. Here, we investigate the levels and trophic transfer of 9 sulfonamide (SA), 5 fluoroquinolone (FQ), and 4 macrolide (ML) antibiotics, as well as trimethoprim in nine invertebrate and ten fish species collected from a marine food web in Laizhou Bay, North China in 2014 and 2015. All th ...
... Kirby–Bauer tests were used to analyze the antibiotic resistance of 224 isolates of Riemerella anatipestifer isolated between 1998 and 2005. Among the 36 antibiotics tested, 50% of the analyzed isolates were resistant to ampicillin, ceftazidime, aztreonam, cefazolin, cefepime, cefuroxime, oxacillin, penicillin G, rifampin, and trimethoprim/sulfamethoxazole. Higher levels of resistance were detecte ...
... This review describes the recent research activities in China in relation to studies on antibiotic biosynthetic pathways and pathway engineering in actinomycetes. 75 references are cited. ...
... Antibiotic micro-pollution is usually found at the ng/L–level in drinking water sources or discharge water of wastewater treatment plants. In this study, a novel approach mediated by manganese oxidizing bacteria (MnOB) in a biofilter was developed to control the pollution. The results indicated that the biogenic manganese oxide (MnOₓ) produced during the oxidation of the feeding manganese ions cou ...
Flavobacteria; algae; antibiotic residues; antibiotics; bacterial communities; environmental assessment; gamma-Proteobacteria; invertebrates; ofloxacin; risk; risk assessment; river water; rivers; sediments; sulfamethazine; sulfamethoxazole; watersheds; Australia; China; Europe; North America
Abstract:
... For the past fewer years, environment antibiotic residues have got more and more attention. The occurrence and distribution of eight common antibiotics, belonging to five classes, were determined in both water and sediment of eleven rivers of Hong Kong. The target antibiotics were found to be widely distributed. Sulfamethoxazole (n.d.–79.9 ng/L), sulfadimidine (n.d.–29.9 ng/L), and ofloxacin (n.d. ...
chickens; maximum residue limits; quinolones; tandem mass spectrometry; tetracycline; China
Abstract:
... Thirty-nine kinds of antibiotics (11 quinolones, 10 tetracyclines, and 18 sulphonamides) residues were screened in 146 samples including chicken, chicken giblets, and eggs in Fujian by ultra-performance liquid chromatography–tandem mass spectrometry (LC-MS/MS) and analysed the contamination status of antibiotic residues.seventeen kinds of antibiotics were detected, with an overall detection rate o ...
antibiotic resistance; antibiotics; bacteria; burden of disease; control methods; disease control; health services; multiple drug resistance; pathogens; population density; tuberculosis; China
Abstract:
... The People's Republic of China, commonly known as China, comprises approximately one-fifth of the world's population. Because of the expanding size and density of its population and the frequent interaction of people with animals, China is a hotspot for the emergence and spread of new microbial threats and is a major contributor to the worldwide infectious disease burden. In recent years, the emer ...
... The occurrence of antibiotic resistance genes (ARGs) and their associated environmental factors in estuaries are poorly understood. In this study, we comprehensively analyzed ARGs in both water and sediments from inlet to outlet of the Yangtze Estuary, China. The relative abundances of ARGs were higher in the turbidity maximum zone (TMZ) than other sites, implying that suspended particulate matter ...
antibiotic resistance; antibiotic resistance genes; antibiotics; bacteria; environmental factors; heavy metals; human health; humans; pH; risk; risk assessment; sediments; sludge; soil; surface water; synergism; wastewater; China
Abstract:
... Antibiotic resistance has become a widely concerned issue due to the huge risk on the ecological environment and human health. China has the highest production and consumption of antibiotics than other countries. Thus, antibiotic resistance genes (ARGs) have been detected in various environmental settings (e.g., surface water, wastewater, sediment) in China. The occurrence of ARGs in these matrixe ...
antibiotic resistance; antibiotics; eutrophication; genes; genetic resistance; heavy metals; humans; lakes; plasmids; quinolones; surface water; transporters; China
Abstract:
... Urban lakes are impacted by heavy human activities and represent potential reservoirs for antibiotic resistance genes. In this study, six urban lakes in Wuhan, central China were selected to analyze the distribution of sulfonamide resistance (sul) genes, tetracycline resistance (tet) genes and quinolone resistance (qnr) genes and their relationship with heavy metals, antibiotics, lake morphology a ...
... Bacteria of the genus Myroides (Myroides spp.) are rare opportunistic pathogens. Myroides sp. infections have been reported mainly in China. Myroides sp. is highly resistant to most available antibiotics, but the resistance mechanisms are not fully elucidated. Current strain identification methods based on biochemical traits are unable to identify strains accurately at the species level. While 16S ...
antibiotic resistance; antibiotic resistance genes; antibiotics; human health; humans; lakes; metagenomics; microbial communities; plasmids; pollution; risk; risk assessment; China
Abstract:
... The increasing pollution of urban drinking water sources by antibiotic resistance genes (ARGs) threatens human health worldwide. However, the distribution and influencing factors of ARGs, especially how to reveal the risks of ARGs in this environment remains unclear. Hence, Chaohu Lake was selected as an example to investigate the characteristics of ARGs and explore the interactions among physicoc ...
... High throughput sequencing-based metagenomic analysis and network analysis were applied to investigate the broad-spectrum profiles of ARGs in landfill leachate from 12 cities in China. In total, 526 ARG subtypes belonging to 21 ARG types were detected with abundances ranging from 1.1 × 10⁻⁶ to 2.09 × 10⁻¹ copy of ARG/copy of 16S rRNA gene. 68 ARG subtypes that accounted for 73.4%–93.4% of the tota ...
animal husbandry; antibiotic resistance genes; antibiotics; composts; human health; pig manure; taxonomy; China
Abstract:
... Antibiotic resistance genes comprising antibiotic resistome are of great concern due to their increase in the environment. Recent evidence of shared resistomes between soils and animal husbandry has imposed potential risks to human health. However, the correlation between a given community’s resistome and bacterial taxonomic composition is controversial. Here, a transmission chain of resistomes fr ...
... Antibiotic resistance genes (ARGs) can survive the water treatment process. However, the prevalence patterns, key drivers, and relationships with opportunistic pathogens of the antibiotic resistome harbored in drinking water sources remain unclear. Herein, 53 drinking water samples collected across a large geographical scale in China were characterized based on ARGs, mobile genetic elements (MGEs) ...
... The overuse of veterinary antibiotics in animal production and the subsequent land applications of manures contribute to the elevated antibiotic resistance in the soil environment. To minimize the risk of antibiotic resistance, it is important to understand the fate of antibiotics and the spread of antibiotic resistance genes (ARGs) from animal production systems to soil. In this paper, we review ...
... The aquaculture industry has developed rapidly in recent years, and in China Crayfish Procambarus clarkii represent an important aquaculture fishery. However, bacterial and viral diseases are becoming an increasingly serious threat, causing considerable economic losses. Farmers use a large number of drugs and chemicals to destroy pathogenic microorganisms and to purify aquaculture water. The purpo ...
antibiotics; biofilters; ecosystems; macrolides; monitoring; quinolones; rivers; sulfadiazine; wastewater; wastewater treatment; water quality; China
Abstract:
... 22 representative antibiotics, including 8 quinolones (QNs), 9 sulfonamides (SAs), and 5 macrolides (MCs) were selected to investigate their occurrence and removal efficiencies in a Wastewater Treatment Plant (WWTP) and their distribution in the receiving water of the Chaobai River in Beijing, China. Water quality monitoring was performed in an integrated way at different selected points in the WW ...
... Antibiotics are of particular concern because of their ubiquity in aquatic environment and long-term adverse effects on aquatic organisms and humans. However, there is no information about the bioaccumulation and trophic magnification of antibiotics in subtropical environments. In this study, we determined the concentrations of 22 antibiotics to investigate their occurrence, bioaccumulation and tr ...
... The extensive use of antibiotics globally and their residues in the environment has become a serious concern. Intensive animal farming is considered to be a major contributor to the increased environmental burden of antibiotics. Although some antibiotic investigations have been advancing around the world, as an important agricultural country, the information on these pollutants in animal farms are ...
antibiotics; aquaculture; ciprofloxacin; dietary exposure; enrofloxacin; feces; fish; fish feeds; health effects assessments; high performance liquid chromatography; human health; metabolism; muscles; ofloxacin; organic matter; pollution; relative risk; research; sediments; sulfadiazine; sulfamethazine; sulfamethoxazole; surface water; urine; China
Abstract:
... Antibiotics have been widely used to prevent or treat bacterial infections in aquaculture in the past decades. However, large proportions of these compounds are excreted unchanged in feces and urine of animals, given incomplete metabolism, leading to the residual of unmetabolized compounds, and posing a potential risk to the environment. This study investigated the occurrence and distribution of s ...
Hoang Quoc Anh; Thi Phuong Quynh Le; Nhu Da Le; Xi Xi Lu; Thi Thuy Duong; Josette Garnier; Emma Rochelle-Newall; Shurong Zhang; Neung-Hwan Oh; Chantha Oeurng; Chaiwat Ekkawatpanit; Tien Dat Nguyen; Quang Trung Nguyen; Tran Dung Nguyen; Trong Nghia Nguyen; Thi Lieu Tran; Tatsuya Kunisue; Rumi Tanoue; Shin Takahashi; Tu Binh Minh; Huu Tuyen Le; Thi Ngoc Mai Pham; Thi Anh Huong Nguyen
antibiotic resistance; antibiotics; aquaculture; environment; issues and policy; livestock production; pollution; sewage; surface water; wastewater; wastewater treatment; China; South East Asia; South Korea
Abstract:
... This review provides focused insights into the contamination status, sources, and ecological risks associated with multiple classes of antibiotics in surface water from the East and Southeast Asia based on publications over the period 2007 to 2020. Antibiotics are ubiquitous in surface water of these countries with concentrations ranging from <1 ng/L to hundreds μg/L and median values from 10 to 1 ...
antibiotic resistance genes; antibiotics; aquatic environment; aquatic organisms; economic development; human health; lakes; maximum residue limits; quinolones; risk; sediments; China
Abstract:
... The potential threat of antibiotics to the environment and human health has raised significant concerns in recent years. The consumption and production of antibiotics in China are the highest in the world due to its rapid economic development and huge population, possibly resulting in the high detection frequencies and concentrations of antibiotics in aquatic environments of China. As a water reso ...
antibiotics; fish; pollution; population density; research; risk; sulfadiazine; sulfamerazine; sulfapyridine; surface water; China
Abstract:
... The widespread existence of antibiotics has caused inevitable influence on ecology and humans. In this study, we screened the most commonly used antibiotics, and 64 antibiotics were detected in Shanghai, an international metropolis. Most of the target substances were detected in all 46 water samples including main rivers and districts in Shanghai, with concentrations ranging from 0.02 to 502.43 ng ...
antibiotics; food consumption; food frequency questionnaires; health effects assessments; humans; meat; milk; pollution; urine; China
Abstract:
... Diet is known to be one of the main sources from which human intake many environmental contaminants, for example, antibiotics. To determine the effect of dietary factors on antibiotic intake, we identified the levels of antibiotics present in the urine of the general population from two regions of Shanghai. Moreover, we assessed the amount of exposure to these substances and the health risks they ...
... The occurrence, spatiotemporal distribution and ecological risks of 27 antibiotics in water and sediments from rivers and coastal area of Zhuhai, Pearl River estuary, south China were investigated. Higher concentrations of antibiotics were found in river water in dry season than those in wet season (p < 0.01), especially for quinolones (QNs) (6.36–463 ng/L) and aminoglycosides (AGs) (94.9–458 ng/L ...
... BACKGROUND: Drug resistance in bacteria has become a global concern and the search for new antibacterial agents is urgent and ongoing. Endophytes provide an abundant reservoir of bioactive metabolites for medicinal exploitation, and an increasing number of novel compounds are being isolated from endophytic fungi. Ophiopogon japonicus, containing compounds with antibacterial activity, is a traditio ...
RNA-directed DNA polymerase; Streptomyces; anthracyclines; antibacterial properties; antibiotics; biological control; biosynthesis; genes; indoles; lakes; lichens; metabolites; new species; prediction; research; symbionts; symbiosis; China
Abstract:
... Actinobacteria that inhabit lichen symbionts are considered a promising yet previously underexplored source of novel compounds. Here, for the first time, we conducted a comprehensive investigation with regard to strain isolation and identification of lichen-associated actinobacteria from Tibet Plateau, antimicrobial activity screening, biosynthetic genes detection, bioactive metabolites identifica ...
... This study was conducted to test the distribution of diarrheagenic Escherichia coli (DEC) associated genes in fecal isolates from diarrheic yaks of a high remote region of China. Briefly, we obtained 203 fecal samples from diarrheic adult yaks and E. coli strains were isolated and identified via standard methods The antibiotic sensitivity of isolates was determined via disk diffusion method and po ...
... One thousand and thirty Escherichia coli isolates from food animals, animals-derived foods, and companion animals between 2007 and 2008 in Southern China were used to investigate their antimicrobial susceptibility to 14 different antimicrobials by the standard agar dilution method. More than 70% of isolates showed resistance to tetracycline, trimethoprim-sulphamethoxazole, nalidixic acid, and ampi ...
... Patrinia villosa Juss is a famous medicinal herb and is used as an anti-inflammatory and anti-bacterial agent. Its tender leaves have also been used as a wild vegetable in China. In this study, the antioxidant and cytotoxic activities of various fractions of ethanol extract from P. villosa were investigated, the ethyl acetate fraction (EE-PV) exhibited the strongest antioxidant activity and cytoto ...