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You searched for: Subject term Cornus officinalis Remove constraint Subject term: Cornus officinalis Subject term neuroprotective effect Remove constraint Subject term: neuroprotective effect
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1. Neuroprotective iridoid glycosides from Cornus officinalis fruits against glutamate-induced toxicity in HT22 hippocampal cells

Author:
Eun Ju Jeong; Tae Bum Kim; Heejung Yang; So Young Kang; Sun Yeou Kim; Sang Hyun Sung; Young Choong Kim
Source:
Phytomedicine 2012 v.19 no.3-4 pp. 317-321
ISSN:
0944-7113
Subject:
Cornus officinalis; fruits; hydrolysis; loganin; neuroprotective effect; toxicity
Abstract:
... The methanolic extract of the fruits of Cornus officinalis S et Z. (Cornaceae) showed the significant neuroprotective activity against glutamate-induced toxicity in HT22 hippocampal cells. Chemical profile of n-BuOH fraction of the methanolic extract of C. officinalis fruits, which showed the most potent activity, was established using HPLC-diode array detector-electrospray-MS (HPLC-DAD-ESI-MS). T ...
DOI:
10.1016/j.phymed.2011.08.068

2. RETRACTION: Neuroprotective effect of Liuwei Dihuang decoction on cognition deficits of diabetic encephalopathy in streptozotocin-induced diabetic rat

Author:
Ji-ping Liu; Liang Feng; Ming-hua Zhang; Dong-ying Ma; Shu-yuan Wang; Junfei Gu; Qiang Fu; Rong Qu; Shi-ping Ma
Source:
Journal of ethnopharmacology 2013 v.150 no.1 pp. 371-381
ISSN:
0378-8741
Subject:
Alisma; Cornus officinalis; Dioscorea oppositifolia; Oriental traditional medicine; Paeoniaceae; Rehmannia glutinosa; Scrophulariaceae; Wolfiporia cocos; acetylcholinesterase; apoptosis; blood glucose; caspase-3; cerebral cortex; choline acetyltransferase; cognition; diet; drugs; encephalopathy; hippocampus; immunohistochemistry; insulin-like growth factor I; intraperitoneal injection; memory; models; neuroprotective effect; protein synthesis; rats; wolves; China
Abstract:
... ETHNOPHARMACOLOGICAL RELEVANCE: Liuwei Dihuang decoction (LWDHD) is a well-known prescription of traditional Chinese medicine (TCM) and consists of six crude drugs including Rehmannia glutinosa Libosch. (family: Scrophulariaceae), Cornus officinalis Sieb. (family: Cornaceae), Dioscorea oppositifolia L. (family: Dioscoreaceae), Paoenia ostii (family: Paeoniaceae), Alisma orientale (G. Samuelsson) J ...
DOI:
10.1016/j.jep.2013.09.003
PubMed:
24041458

3. p-Coumaric Acid and Ursolic Acid from Corni fructus Attenuated β-Amyloid25–35-Induced Toxicity through Regulation of the NF-κB Signaling Pathway in PC12 Cells

Author:
Jeong-Hyun Yoon; Kumju Youn; Chi-Tang Ho; Mukund V. Karwe; Woo-Sik Jeong; Mira Jun
Source:
Journal of agricultural and food chemistry 2014 v.62 no.21 pp. 4911-4916
ISSN:
0021-8561
Subject:
Alzheimer disease; Cornus officinalis; inducible nitric oxide synthase; mitogen-activated protein kinase; neuroprotective effect; p-coumaric acid; pathogenesis; phosphorylation; signal transduction; toxicity; transcription factor NF-kappa B; ursolic acid
Abstract:
... Neuroinflammatory responses induced by amyloid-beta peptide (Aβ) are important causes in the pathogenesis of Alzheimer’s disease (AD). Blockade of Aβ has emerged as a possible therapeutic approach to control the onset of AD. This study investigated the neuroprotective effects and molecular mechanisms of p-coumaric acid (p-CA) and ursolic acid (UA) from Corni fructus against Aβ25–35-induced ...
DOI:
10.1021/jf501314g

4. Ethnopharmacology, phytochemistry, and pharmacology of Cornus officinalis Sieb. et Zucc

Author:
Jun Huang; Yiwei Zhang; Lin Dong; Qinghan Gao; Lei Yin; Hongfeng Quan; Rong Chen; Xueyan Fu; Dingbo Lin
Source:
Journal of ethnopharmacology 2017 pp. -
ISSN:
0378-8741
Subject:
Cornus officinalis; Internet; Oriental traditional medicine; analgesic effect; analytical methods; anti-aging properties; antineoplastic activity; cardioprotective effect; chemical composition; chemical constituents of plants; drugs; fruits; glycemic effect; herbs; hypertension; immunomodulation; kidneys; knees; loganin; neuroprotective effect; organic acids and salts; pain; quality control; renoprotective effect; therapeutics; toxicology; waist; China
Abstract:
... Cornus officinalis (Cornaceae), known in Chinese as “Shanzhuyu,” is a frequently used traditional Chinese medicine. It tastes sour and is astringent and slightly warm in nature. Its fruits have long been used to treat kidney deficiency, high blood pressure, waist and knee pain, dizziness, tinnitus, impotence, spermatorrhea, menorrhagia, and other diseases in China. The main distribution areas are ...
DOI:
10.1016/j.jep.2017.11.010

5. Four new iridoid glucosides containing the furan ring from the fruit of Cornus officinalis

Author:
Jun He; Xian-Sheng Ye; Xiao-Xue Wang; Ya-Nan Yang; Pei-Cheng Zhang; Bing-Zhi Ma; Wei-Ku Zhang; Jie-Kun Xu
Source:
Fitoterapia 2017 pp. -
ISSN:
0367-326X
Subject:
Cornus officinalis; chemical structure; circular dichroism spectroscopy; glucosides; iridoid glycosides; neuroprotective effect; nuclear magnetic resonance spectroscopy; spectral analysis; sugars
Abstract:
... Four new and rare iridoid glucosides, cornusfuroside A–D (1–4), containing the furan ring were identified from water extract of the fruit of Cornus officinalis. These new chemical structures were determined through extensive spectroscopic analysis, including 1D and 2D NMR, IR, HRESIMS, experimental and calculated electronic circular dichroism (ECD). Notably, this study is the first report on the i ...
DOI:
10.1016/j.fitote.2017.06.003

6. Iridoid glycosides from the fruits of Cornus officinalis

Author:
Xin Wang; Chong-Hui Liu; Jin-Jie Li; Bo Zhang; Lin-Lin Ji; Xiao-Ya Shang
Source:
Journal of Asian natural products research 2018 v.20 no.10 pp. 934-942
ISSN:
1477-2213
Subject:
Cornus officinalis; ethanol; fruits; iridoid glycosides; neuroprotective effect; nuclear magnetic resonance spectroscopy; spectral analysis
Abstract:
... Four new iridoid glycosides named cornusphenosides A–D (1–4) were isolated from an ethanol extract of the fruits of Cornus officinalis (shan zhu yu). The structures of these compounds were elucidated on the basis of spectroscopic data (UV, IR, HRESIMS, and 1D and 2D NMR) and chemical evidence. The neuroprotective effects of compounds 1–4 were also assessed in vitro. ...
DOI:
10.1080/10286020.2018.1497609

7. Cornel iridoid glycoside exerts a neuroprotective effect on neuroinflammation in rats with brain injury by inhibiting NF-κB and STAT3

Author:
Tingting Zheng; Jiao Peng; Tao Pei; Yu Shi; Li Liu; Keke Chen; Haitao Xiao; Yun Chen
Source:
3 Biotech 2019 v.9 no.5 pp. 195
ISSN:
2190-572X
Subject:
Cornus officinalis; active ingredients; antioxidants; apoptosis; brain damage; cognitive disorders; histopathology; inflammation; interleukin-6; iridoid glycosides; lipid peroxidation; messenger RNA; mortality; neuroprotective effect; protein content; rats; therapeutics; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:
... Traumatic brain injury leads to problems with movement and cognitive deficits and has a high mortality rate. Cornel iridoid glycoside, the active ingredient of Cornus officinalis, has been reported to ameliorate apoptosis and inflammation in rats. We investigated the therapeutic effect of cornel iridoid glycoside on neuroinflammation in rats with brain injury. Rats were treated with cornel iridoid ...
DOI:
10.1007/s13205-019-1697-5
PubMed:
31065495
PubMed Central:
PMC6497687

8. Neuroprotective Effects of Cornus officinalis on Stress-Induced Hippocampal Deficits in Rats and H2O2-Induced Neurotoxicity in SH-SY5Y Neuroblastoma Cells

Author:
Weishun Tian; Jing Zhao; Jeong-Ho Lee; Md Rashedunnabi Akanda; Jeong-Hwi Cho; Sang-Ki Kim; Yu-Jin Choi; Byung-Yong Park
Source:
Antioxidants 2019 v.9 no.1 pp. -
ISSN:
2076-3921
Subject:
Cornus officinalis; apoptosis; catalase; corticosterone; forced swimming test; lactate dehydrogenase; mitogen-activated protein kinase; neurons; neuroprotective effect; neurotoxicity; oxidative stress; phosphorylation; reactive oxygen species; serotonin; superoxide dismutase
Abstract:
... Oxidative stress plays a vital role in neurodegenerative diseases. Cornus officinalis (CC) has a wide range of pharmacological activities (e.g., antioxidant, neuroprotective, and anti-inflammatory). The present study was undertaken to elucidate the neuroprotective mechanism of CC and fermented CC (FCC) on stress and H2O2-induced oxidative stress damage in rats and SH-S ...
DOI:
10.3390/antiox9010027

9. The novel protective effects of loganin against 1‐methyl‐4‐phenylpyridinium‐induced neurotoxicity: Enhancement of neurotrophic signaling, activation of IGF‐1R/GLP‐1R, and inhibition of RhoA/ROCK pathway

Author:
Yu‐Ting Tseng; Wan‐Jung Lin; Wan‐Hsuan Chang; Yi‐Ching Lo
Source:
Phytotherapy research 2019 v.33 no.3 pp. 690-701
ISSN:
0951-418X
Subject:
Cornus officinalis; Parkinson disease; antagonists; apoptosis; cytotoxicity; fruits; glucagon-like peptide receptors; insulin-like growth factor I receptor; loganin; models; neurites; neuroprotective effect; neurotoxicity; osteoporosis; oxidative stress; reactive oxygen species; tyrosine 3-monooxygenase
Abstract:
... Loganin, a major iridoid glycoside obtained from fruits of Cornus officinalis, possesses anti‐inflammatory, antitumor, antidiabetic, and osteoporosis prevention effects. Loganin has been linked to neuroprotection in several models of neurodegeneration, including Parkinson's disease (PD). However, mechanisms underlying the neuroprotective effects of loganin are still mostly unknown. Here, we demons ...
DOI:
10.1002/ptr.6259

10. Cornuside Is a Potential Agent against Alzheimer’s Disease via Orchestration of Reactive Astrocytes

Author:
Jun-Zhuo Shi; Xiao-Ming Zheng; Yun-Feng Zhou; Lu-Yao Yun; Dong-Mei Luo; Jiao-Jiao Hao; Peng-Fei Liu; Wei-Ku Zhang; Jie-Kun Xu; Yi Yan; Xin-Mei Xie; Yang-Yang He; Xiao-Bin Pang
Source:
Nutrients 2022 v.14 no.15 pp. -
ISSN:
2072-6643
Subject:
Cornus officinalis; amyloid; antioxidants; astrocytes; cognitive disorders; glutathione peroxidase; interleukin-6; iridoid glycosides; lipopolysaccharides; malondialdehyde; memory; necrosis; neoplasms; neurons; neuroplasticity; neuroprotective effect; nitric oxide; oxidative stress; phenotype; phosphorylation; superoxide dismutase
Abstract:
... Cornuside is an iridoid glycoside from Cornus officinalis, with the activities of anti-inflammatory, antioxidant, anti-mitochondrial dysfunction, and neuroprotection. In the present research, a triple-transgenic mice model of AD (3 × Tg-AD) was used to explore the beneficial actions and potential mechanism of cornuside on the memory deficits. We found that cornuside prominently alleviated neuronal ...
DOI:
10.3390/nu14153179

11. Secoiridoid glycosides from the fruits of Cornus officinalis

Author:
Xin Wang; Xiang-Jian Zhong; Na Zhou; Lin-Lin Ji; Jin-Jie Li; Ning Cai; Qing-Bo Wang; Peng-Cheng Lin; Xiao-Ya Shang
Source:
Natural product research 2022 v.36 no.9 pp. 2329-2335
ISSN:
1478-6427
Subject:
Cornus officinalis; ethanol; glycosides; neuroprotective effect; research; spectral analysis
Abstract:
... Five new secoiridoid glycosides, cornusphenosides E-I (1–5), were isolated and characterized from an active fraction of ethanol extract of the fruits of Cornus officinalis. Their structures were determined by extensive spectroscopic data analysis, including 2 D NMR and HRESIMS experiments. In the preliminary assay, compound 5 (when evaluated at 10 μM) showed the neuroprotective effect against H₂O₂ ...
DOI:
10.1080/14786419.2020.1834547