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- Gryko, Dorota, et al. Show all 6 Authors
- Chemical communications 2019 v.55 no.6 pp. 763-766
- DNA; Escherichia coli; RNA; Salmonella Typhimurium; alkynes; antibiotics; bacteria; chemical reactions; genes; oligonucleotides; protein synthesis; therapeutics; vitamin B12
- ... Specifically designed, antisense oligonucleotides are promising candidates for antibacterial drugs. They suppress the correct expression of bacterial genes by complementary binding to essential sequences of bacterial DNA or RNA. The main obstacle in fully utilizing their potential as therapeutic agents comes from the fact that bacteria do not uptake oligonucleotides from their environment. Herein, ...
- Gryko, Dorota, et al. Show all 5 Authors
- The Journal of physical chemistry 2017 v.121 no.14 pp. 2968-2979
- DNA; RNA; bacteria; chemical bonding; gene expression; mammals; molecular dynamics; nuclear magnetic resonance spectroscopy; solvents; transcription (genetics); translation (genetics); triazoles; vitamin B12
- ... Vitamin B₁₂ also called cobalamin (Cbl) is an important enzymatic cofactor taken up by mammalian and also by many bacterial cells. Peptide nucleic acid (PNA) is a synthetic DNA analogue that has the ability to bind in a complementary manner to natural nucleic acids. Provided that PNA is efficiently delivered to cells, it could act as a steric blocker of functional DNA or RNA and regulate gene expr ...