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1. WT1 Recruits TET2 to Regulate Its Target Gene Expression and Suppress Leukemia Cell Proliferation

Author:
Ren, Ruibao,   et al.   ; Wang, Yiping; Xiao, Mengtao; Chen, Xiufei; Chen, Leilei; Xu, Yanping; Lv, Lei; Wang, Pu; Yang, Hui; Ma, Shenghong; Lin, Huaipeng; Jiao, Bo; Ye, Dan; Guan, Kun-Liang; Xiong, Yue;     Show all 15 Authors
Source:
Molecular cell 2015 v.57 pp. 662-673
ISSN:
1097-2765
Subject:
DNA; DNA methylation; carcinogenesis; cell proliferation; enzymes; gene expression; genes; mutation; myeloid leukemia; neoplasm cells; nucleotide sequences; transcription factors
Abstract:
... The TET2 DNA dioxygenase regulates cell identity and suppresses tumorigenesis by modulating DNA methylation and expression of a large number of genes. How TET2, like most other chromatin-modifying enzymes, is recruited to specific genomic sites is unknown. Here we report that WT1, a sequence-specific transcription factor, is mutated in a mutually exclusive manner with TET2, IDH1, and IDH2 in acute ...
DOI:
10.1016/j.molcel.2014.12.023
PubMed:
25601757
PubMed Central:
PMC4336627