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- Ren, Ruibao, et al. Show all 15 Authors
- Molecular cell 2015 v.57 pp. 662-673
- DNA; DNA methylation; carcinogenesis; cell proliferation; enzymes; gene expression; genes; mutation; myeloid leukemia; neoplasm cells; nucleotide sequences; transcription factors
- ... The TET2 DNA dioxygenase regulates cell identity and suppresses tumorigenesis by modulating DNA methylation and expression of a large number of genes. How TET2, like most other chromatin-modifying enzymes, is recruited to specific genomic sites is unknown. Here we report that WT1, a sequence-specific transcription factor, is mutated in a mutually exclusive manner with TET2, IDH1, and IDH2 in acute ...
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