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1. Perigestational exposure to low doses of PBDE-47 induces excessive ER stress, defective autophagy and the resultant apoptosis contributing to maternal thyroid toxicity

Author:
Liu, Luming,   et al.   ; Li, Pei; Zhou, Guoyu; Tian, Zhiyuan; Luo, Chen; Xia, Tao; Chen, Jingwen; Niu, Qiang; Dong, Lixin; Zhao, Qian; Wang, Aiguo; Zhang, Shun;     Show all 12 Authors
Source:
The Science of the total environment 2018 v.645 pp. 363-371
ISSN:
0048-9697
Subject:
DNA fragmentation; apoptosis; autophagy; blood serum; brain; caspase-12; caspase-3; endoplasmic reticulum; epithelial cells; females; fetus; flame retardants; gene expression regulation; infants; laboratory animals; mechanism of action; neurotoxicity; progeny; rats; triiodothyronine; unfolded protein response; weaning
Abstract:
... Brominated flame retardant 2,2′,4,4′‑tetrabromodiphenyl ether (PBDE-47) is known to induce developmental neurotoxicity by disturbing thyroid hormones (THs). Evidence shows that maternal THs are crucial for brain development and growth of fetuses and infants. However, little is known about the effects of PBDE-47 on maternal thyroid status and its mode of action. Here, using female Sprague-Dawley ra ...
DOI:
10.1016/j.scitotenv.2018.07.138