Jump to Main Content
- Rahmani, Soheila; Pour Khalili, Nazila; Khan, Fazlullah; Hassani, Shokoufeh; Ghafour-Boroujerdi, Elmira; Abdollahi, Mohammad
- Life sciences 2018 v.214 pp. 136-144
- DNA methylation; adipocytes; animals; bisphenol A; demethylation; endocrine-disrupting chemicals; epigenetics; estrogenic properties; fatty liver; genes; glucose; histones; homeostasis; insulin; islets of Langerhans; lipids; liver; microRNA; noninsulin-dependent diabetes mellitus; obesity; pollution; skeletal muscle; toxicity
- ... Nowadays, endocrine disrupting chemical pollution has become one of the major concerns due to the potential role of these chemicals in provoking endocrine disorders especially type 2 diabetes. As a widespread endocrine disrupting chemical, Bisphenol A, with modest estrogenic activity can exert its detrimental effects in the different organs involved in type 2 diabetes such as pancreas, liver, adip ...
- Hong, Jieyun; Wang, Xiaoyu; Mei, Chugang; Zan, Linsen
- Gene 2019 v.684 pp. 39-46
- DNA methylation; NAD (coenzyme); adipocytes; binding sites; cattle; chromatin; demethylation; enzyme activity; gel electrophoresis; genomic islands; homeostasis; luciferase; mitochondria; molecular cloning; precipitin tests; promoter regions; stress tolerance; transactivators; transcription (genetics); transcriptional activation; transferases
- ... Sirtuin 5 (SIRT5) belongs to the mitochondrial sirtuin family, which constitutes a highly conserved family of nicotinamide adenine dinucleotide NAD+-dependent deacetylases and ADP-ribosyltransferases that play important regulatory roles in stress resistance and metabolic homeostasis. SIRT5 was shown to have deacetylase, desuccinylase, and demalonylase activities. However, the mechanisms regulating ...