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- Author:
- José Jaime Martínez-Magaña; Sandra Hernandez; Ana Rosa Garcia; Valeria Cardoso-Barajas; Emmanuel Sarmiento; Beatriz Camarena; Alejandro Caballero; Laura Gonzalez; Jorge Ameth Villatoro-Velazquez; Maria Elena Medina-Mora; Marycarmen Bustos-Gamiño; Clara Fleiz-Bautista; Carlos Alfonso Tovilla-Zarate; Isela Esther Juárez-Rojop; Humberto Nicolini; Alma Delia Genis-Mendoza
- Source:
- Nutrients 2022 v.14 no.2 pp. -
- ISSN:
- 2072-6643
- Subject:
- DNA methylation; adipocytes; blood; brain; computer simulation; food intake; genetic variation; genome-wide association study; prediction; quantitative traits; regression analysis
- Abstract:
- ... Alterations in eating behavior characterized eating disorders (ED). The genetic factors shared between ED diagnoses have been underexplored. The present study performed a genome-wide association study in individuals with disordered eating behaviors in the Mexican population, blood methylation quantitative trait loci (blood-meQTL), summary data-based Mendelian randomization (SMR) analysis, and in s ...
- DOI:
- 10.3390/nu14020394
- https://doi.org/10.3390/nu14020394
- Author:
- Zhang-Hong Ke; Ai-Li Yu; Xue-Fen Cai; Yan Sun; Hui-Ling Xu; Meng Chen; Chen-Xi Chen; Bei-Hong Zheng
- Source:
- Toxicology 2022 v.473 pp. 153194
- ISSN:
- 0300-483X
- Subject:
- DNA hypomethylation; United States Environmental Protection Agency; adipocytes; adipose tissue; animal models; bisphenol A; blood serum; body weight; free fatty acids; glucose; glycerol; lipolysis; males; subcutaneous injection; toxicology; triacylglycerol lipase
- Abstract:
- ... Accumulating evidence suggests the role of developmental exposure of bisphenol A (BPA) in metabolic disorders. However, the underlying mechanism remains unclear. Using a rat model, we investigated the neonatal exposure of BPA on lipid metabolism in adult and the underlying mechanisms. From postnatal day1(PND1) to PND10, male rats were exposed to BPA via daily subcutaneous injection with 10 µg/100 ...
- DOI:
- 10.1016/j.tox.2022.153194
- https://doi.org/10.1016/j.tox.2022.153194
- Author:
- Małgorzata Małodobra-Mazur; Aneta Cierzniak; Krzysztof Kaliszewski; Tadeusz Dobosz
- Source:
- Genes 2021 v.12 no.6 pp. -
- ISSN:
- 2073-4425
- Subject:
- DNA methylation; adipocytes; adipose tissue; epigenetics; glucose; glucose transporters; humans; insulin; insulin receptors; insulin resistance; obesity; palmitic acid; pathogenesis; peroxisome proliferator-activated receptor gamma; surgery
- Abstract:
- ... Insulin acts by binding with a specific receptor called an insulin receptor (INSR), ending up with glucose transporter activation and glucose uptake. Insulin resistance (IR) is a state when the physiological amount of insulin is not sufficient to evoke proper action, i.e., glucose uptake. Epigenetic modifications associated with obesity and IR are some of the main mechanisms leading to IR pathogen ...
- DOI:
- 10.3390/genes12060889
- https://doi.org/10.3390/genes12060889
- Author:
- Alba Serrano; Madhu Asnani-Kishnani; Charlene Couturier; Julien Astier; Andreu Palou; Jean-François Landrier; Joan Ribot; M. Luisa Bonet
- Source:
- Nutrients 2020 v.12 no.2 pp. -
- ISSN:
- 2072-6643
- Subject:
- DNA; DNA methylation; adipocytes; adulthood; adults; dynamics; epigenetics; genes; high fat diet; males; metabolism; mice; nicotinamide; nutrients; resveratrol; suckling; weaning; white adipose tissue; young animals
- Abstract:
- ... Neonatal supplementation with resveratrol (RSV) or nicotinamide riboside (NR) programs in male mice brown adipocyte-like features in white adipose tissue (WAT browning) together with improved metabolism in adulthood. We tested the involvement in this programming of long-term epigenetic changes in two browning-related genes that are overexpressed in WAT of supplemented mice, Slc27a1 and Prdm16. Suc ...
- DOI:
- 10.3390/nu12020461
- https://doi.org/10.3390/nu12020461
- Author:
- Byung Chul Jung; Sona Kang
- Source:
- Biochimica et biophysica acta 2021 v.1866 no.11 pp. 159019
- ISSN:
- 1388-1981
- Subject:
- DNA methylation; adipocytes; adipose tissue; chromatin; epigenetics; gene expression; genes; histone code; inflammation; insulin resistance; metabolism; nucleotide sequences; obesity; risk factors
- Abstract:
- ... Obesity is a strong risk factor for insulin resistance. Chronic low-grade tissue inflammation and systemic inflammation have been proposed as major mechanisms that promote insulin resistance in obesity. Adipose tissue has been recognized as a nexus between inflammation and metabolism, but how exactly inflammatory gene expression is orchestrated during the development of obesity is not well underst ...
- DOI:
- 10.1016/j.bbalip.2021.159019
- https://doi.org/10.1016/j.bbalip.2021.159019
- Author:
- Qi Qi; Yi Wang; Xiaochen Wang; Junying Yang; Yan Xie; Jie Zhou; Xiaoxia Li; Baoli Wang
- Source:
- Cellular and molecular life sciences 2020 v.77 no.12 pp. 2407-2421
- ISSN:
- 1420-682X
- Subject:
- DNA methylation; adipocytes; adipogenesis; bone formation; chromatin immunoprecipitation; epigenetics; histone demethylases; histones; lysine; mutation; osteoblasts; osteoporosis; therapeutics
- Abstract:
- ... Epigenetic modifications play a central role in cell differentiation and development. In the current study, we have recognized lysine demethylase 4A (KDM4A) as a novel epigenetic regulator of osteoblast and adipocyte differentiation. Kdm4a expression was upregulated during osteogenesis and adipogenesis of primary marrow stromal cells and established stromal ST2 line. Overexpression of wild-type Kd ...
- DOI:
- 10.1007/s00018-019-03289-w
- https://doi.org/10.1007/s00018-019-03289-w
- Author:
- Yingzi Hou; Zhenxi Zhang; Yao Wang; Tao Gao; Xiyang Liu; Tao Tang; Quan Du
- Source:
- Gene 2020 v.733 pp. 144265
- ISSN:
- 0378-1119
- Subject:
- adipocytes; adipogenesis; ascorbic acid; assays; enzymes; gain-of-function mutation; gene expression; genes; genomics; lipids; lipolysis; loss-of-function mutation; methylation
- Abstract:
- ... To explore its roles in adipogenesis, the levels of genomic 5mC methylation were examined across the adipocyte differentiation of 3 T3-L1 cells. This led to the identification of an up-regulating 5mC profile during the process. To further explore the regulation, gene expression assay was performed with a set of 5mC metabolic enzymes. Among them, TET2 was found to be the most regulated 5mC demethyl ...
- DOI:
- 10.1016/j.gene.2019.144265
- https://doi.org/10.1016/j.gene.2019.144265
- Author:
- Ke-di Liu; Animesh Acharjee; Christine Hinz; Sonia Liggi; Antonio Murgia; Julia Denes; Melanie K. Gulston; Xinzhu Wang; Yajing Chu; James A. West; Robert C. Glen; Lee D. Roberts; Andrew J. Murray; Julian L. Griffin
- Source:
- Journal of proteome research 2020 v.19 no.10 pp. 3919-3935
- ISSN:
- 1535-3907
- Subject:
- DNA; adipocytes; cell membranes; choline; diacylglycerols; environmental factors; free fatty acids; genetic engineering; genome; high fat diet; lipid composition; lipid metabolism; lipidomics; membrane proteins; methylation; mice; obesity; phosphatidylcholines; phosphatidylethanolamines; phosphatidylserines; proteome; solid phase extraction; transcription (genetics); triacylglycerols; white adipose tissue
- Abstract:
- ... Obesity is a complex disorder where the genome interacts with diet and environmental factors to ultimately influence body mass, composition, and shape. Numerous studies have investigated how bulk lipid metabolism of adipose tissue changes with obesity and, in particular, how the composition of triglycerides (TGs) changes with increased adipocyte expansion. However, reflecting the analytical challe ...
- DOI:
- 10.1021/acs.jproteome.9b00894
- https://doi.org/10.1021/acs.jproteome.9b00894
- Author:
- Giulia Tini; Vijayalakshmi Varma; Rosario Lombardo; Greg T. Nolen; Gregory Lefebvre; Patrick Descombes; Sylviane Métairon; Corrado Priami; Jim Kaput; Marie-Pier Scott-Boyer
- Source:
- Genes & nutrition 2020 v.15 no.1 pp. 21
- ISSN:
- 1555-8932
- Subject:
- DNA methylation; adipocytes; adipogenesis; fructose; gene expression; gene expression regulation; glucose; humans; metabolism; nutrition; obesity; transcriptomics
- Abstract:
- ... BACKGROUND: Increased adipogenesis and altered adipocyte function contribute to the development of obesity and associated comorbidities. Fructose modified adipocyte metabolism compared to glucose, but the regulatory mechanisms and consequences for obesity are unknown. Genome-wide methylation and global transcriptomics in SGBS pre-adipocytes exposed to 0, 2.5, 5, and 10 mM fructose, added to a 5-mM ...
- DOI:
- 10.1186/s12263-020-00680-2
- https://doi.org/10.1186/s12263-020-00680-2
- Author:
- Masashi Kuroda; Rumi Onoyama; Waka Sasaki; Mayu Sebe; Tadahiro Kitamura; Saeko Masumoto; Rie Tsutsumi; Nagakatsu Harada; Hiroshi Sakaue
- Source:
- Biochemical and biophysical research communications 2020 v.525 no.1 pp. 39-45
- ISSN:
- 0006-291X
- Subject:
- 2-deoxyglucose; DNA methylation; DNA methyltransferase; DNA microarrays; adipocytes; adipogenesis; cell lines; demethylation; glucose; glucose transporters; insulin; insulin receptor substrate proteins; neoplasms; promoter regions; research; signal transduction
- Abstract:
- ... Researchers frequently use 3T3-L1 adipocytes as a fat cell line, but the capacity of this line for insulin-mediated glucose transport is lower than that of primary isolated fat cells. In this study, we found that 5-azacytidine (5-aza-C), DNA methyltransferase 1 inhibitor, enhanced insulin-stimulated 2-deoxyglucose (2-DG) transport in 3T3-L1 cells after adipogenic differentiation. We next examined ...
- DOI:
- 10.1016/j.bbrc.2020.02.038
- https://doi.org/10.1016/j.bbrc.2020.02.038
- Author:
- Jieyun Hong; Xiaoyu Wang; Chugang Mei; Linsen Zan
- Source:
- Gene 2019 v.684 pp. 39-46
- ISSN:
- 0378-1119
- Subject:
- DNA methylation; NAD (coenzyme); adipocytes; binding sites; cattle; chromatin; demethylation; enzyme activity; gel electrophoresis; genomic islands; homeostasis; luciferase; mitochondria; molecular cloning; precipitin tests; promoter regions; stress tolerance; transactivators; transcription (genetics); transcriptional activation; transferases
- Abstract:
- ... Sirtuin 5 (SIRT5) belongs to the mitochondrial sirtuin family, which constitutes a highly conserved family of nicotinamide adenine dinucleotide NAD+-dependent deacetylases and ADP-ribosyltransferases that play important regulatory roles in stress resistance and metabolic homeostasis. SIRT5 was shown to have deacetylase, desuccinylase, and demalonylase activities. However, the mechanisms regulating ...
- DOI:
- 10.1016/j.gene.2018.10.052
- https://doi.org/10.1016/j.gene.2018.10.052
- Author:
- Qing Wang; Xiao Wang; Defang Lai; Jin Deng; Zhuang Hou; Hao Liang; Dongjun Liu
- Source:
- Research in veterinary science 2018 v.119 pp. 9-18
- ISSN:
- 0034-5288
- Subject:
- DNA methylation; adipocytes; apoptosis; cell proliferation; chromatin; droplets; gene expression; goats; histones; leptin; lipids; lysine; methyltransferases; stem cells; transcription (genetics)
- Abstract:
- ... Chromatin remodeling plays an essential role in regulating gene transcription. BIX-01294 is a specific inhibitor of histone methyltransferase G9a, which is responsible for methylation of histone H3 lysine 9 (H3K9) that can also regulate DNA methylation and chromatin remodeling. The purpose of this study was to investigate the effects of BIX-01294 on the potential of goat adipose derived stem cells ...
- DOI:
- 10.1016/j.rvsc.2018.05.009
- https://doi.org/10.1016/j.rvsc.2018.05.009
- Author:
- Soheila Rahmani; Nazila Pour Khalili; Fazlullah Khan; Shokoufeh Hassani; Elmira Ghafour-Boroujerdi; Mohammad Abdollahi
- Source:
- Life sciences 2018 v.214 pp. 136-144
- ISSN:
- 0024-3205
- Subject:
- DNA methylation; adipocytes; animals; bisphenol A; demethylation; endocrine-disrupting chemicals; epigenetics; estrogenic properties; fatty liver; genes; glucose; histones; homeostasis; insulin; islets of Langerhans; lipids; liver; microRNA; noninsulin-dependent diabetes mellitus; obesity; pollution; skeletal muscle; toxicity
- Abstract:
- ... Nowadays, endocrine disrupting chemical pollution has become one of the major concerns due to the potential role of these chemicals in provoking endocrine disorders especially type 2 diabetes. As a widespread endocrine disrupting chemical, Bisphenol A, with modest estrogenic activity can exert its detrimental effects in the different organs involved in type 2 diabetes such as pancreas, liver, adip ...
- DOI:
- 10.1016/j.lfs.2018.10.044
- https://doi.org/10.1016/j.lfs.2018.10.044
- Author:
- Jie-yun Hong; Chu-gang Mei; Shi-jun Li; Hong-bao Wang; Chun-ping Zhao; Lin-sen Zan
- Source:
- Archives of biochemistry and biophysics 2018 v.659 pp. 1-12
- ISSN:
- 0003-9861
- Subject:
- DNA methylation; adipocytes; binding sites; cattle; gel electrophoresis; gene expression; glucose; insulin secretion; lipid metabolism; longissimus muscle; luciferase; messenger RNA; moieties; neoplasms; promoter regions; proto-oncogenes; subcutaneous fat; testes; transactivators; transcription (genetics); transferases
- Abstract:
- ... Sirtuin6 (SIRT6) is an ADP-ribosyltransferase and NAD⁺-dependent deacylase of acetyl groups and long-chain fatty acyl groups, and has been shown as a regulator of insulin secretion, glucose metabolism, lipid metabolism, and cancer. In this study, we determined that the bovine SIRT6 showed higher levels of mRNA expression in the testis, longissimus thoracis, and subcutaneous fat tissue. To elucidat ...
- DOI:
- 10.1016/j.abb.2018.09.018
- https://doi.org/10.1016/j.abb.2018.09.018
- Author:
- Gui-Min Zhang; Cheng-Chuang Song; Li-Juan Li; Hua He; Shu-Yue Shi; Chu-Zhao Lei; Li Zheng; Shu-Jun Peng; Yi-Ran Tian; Rui-Hua Dang; Xian-Yong Lan; Xing-Lei Qi; Hong Chen; Yong-Zhen Huang
- Source:
- Gene 2018 v.676 pp. 243-248
- ISSN:
- 0378-1119
- Subject:
- DNA methylation; absorption; adipocytes; beef quality; binding proteins; bisulfites; cattle; cattle breeds; cell differentiation; epigenetics; fibroblasts; gene expression; gene expression regulation; genes; genomic islands; homeostasis; hybrids; messenger RNA; metabolism; methyltransferases; muscles; neoplasms; phenotype; purebreds; quantitative polymerase chain reaction; retinoic acid; sequence analysis; therapeutics; transcription (genetics)
- Abstract:
- ... As an important epigenetic modification DNA methylation is catalyzed by DNA methylation transferases (DNMTs) and occurs mainly in CpG islands. DNA methylation plays an important role in regulates gene expression, cell differentiation, genetic imprinting and tumor therapy. Retinoic acid-binding proteins (RAC) is vital for the absorption, transport, metabolism and maintenance of homeostasis of retin ...
- DOI:
- 10.1016/j.gene.2018.07.049
- https://doi.org/10.1016/j.gene.2018.07.049
- Author:
- Eva García-Escobar; Roberto Monastero; Sara García-Serrano; Juan M. Gómez-Zumaquero; Ana Lago-Sampedro; Elehazara Rubio-Martín; Natalia Colomo; Francisca Rodríguez-Pacheco; Federico Soriguer; Gemma Rojo-Martínez
- Source:
- Journal of nutritional biochemistry 2017 v.47 pp. 106-112
- ISSN:
- 0955-2863
- Subject:
- DNA; DNA methylation; acid treatment; adipocytes; adipose tissue; dietary fat; epigenetics; gene expression; linoleic acid; metabolic syndrome; oleic acid; palmitic acid; polyunsaturated fatty acids; protein content; rats; secretion; therapeutics; tumor necrosis factor-alpha
- Abstract:
- ... The factors regulating TNF alpha (TNFa) levels could be considered therapeutic targets against metabolic syndrome development. DNA methylation is a potent regulator of gene expression and may be associated with protein levels. In this study we investigate whether the effect of dietary fatty acids on TNFa released from adipocytes might be associated with modifications of the TNFa promoter DNA methy ...
- DOI:
- 10.1016/j.jnutbio.2017.05.006
- https://doi.org/10.1016/j.jnutbio.2017.05.006
- Author:
- Wei Li; Renqiao Tang; Feifei Ma; Shengrong Ouyang; Zhuo Liu; Jianxin Wu
- Source:
- Journal of nutritional biochemistry 2018 v.59 pp. 76-83
- ISSN:
- 0955-2863
- Subject:
- DNA methylation; adipocytes; adipose tissue; animal disease models; blood glucose; drinking water; epididymis; folic acid; genes; glucose; high fat diet; insulin; insulin resistance; insulin secretion; mice; noninsulin-dependent diabetes mellitus; obesity; precipitin tests
- Abstract:
- ... Folic acid (FA) supplementation may protect from obesity and insulin resistance, the effects and mechanism of FA on chronic high-fat-diet-induced obesity-related metabolic disorders are not well elucidated. We adopted a genome-wide approach to directly examine whether FA supplementation affects the DNA methylation profile of mouse adipose tissue and identify the functional consequences of these ch ...
- DOI:
- 10.1016/j.jnutbio.2018.05.010
- https://doi.org/10.1016/j.jnutbio.2018.05.010
- Author:
- Yu-Hua Yang; Ru-Zhi Zhang; Sai Cheng; Bin Xu; Ting Tian; Hai-Xia Shi; Li Xiao; Ren-He Chen
- Source:
- Cellular reprogramming 2018 v.20 no.6 pp. 356-364
- ISSN:
- 2152-4998
- Subject:
- DNA methylation; Lentivirus; adipocytes; culture dishes; dyes; ectoderm; embryonic stem cells; epidermis (animal); hepatocytes; humans; induced pluripotent stem cells; keratinocytes; mice; staining; therapeutics; transcription factors; transfection
- Abstract:
- ... Induced pluripotent stem cells (iPSCs) play an important role in cell replacement therapy. Several studies have shown that keratinocytes are promising reprogrammed cells. We easily and efficiently enriched epidermal stem cells by attaching them for a limited time in culture dishes. Individual epidermal cells enriched in stem cells, which showed strong immunostaining for K15, were obtained and gene ...
- DOI:
- 10.1089/cell.2018.0035
- https://doi.org/10.1089/cell.2018.0035
- Author:
- Wenjuan Tan; Zhiping Zhu; Lan Ye; Lai K. Leung
- Source:
- Molecular and Cellular Endocrinology 2017 v.452 pp. 131-137
- ISSN:
- 0303-7207
- Subject:
- DNA methylation; adipocytes; aromatase; brain; epigenetics; genes; humans; messenger RNA; models; neuroglia; neurons
- Abstract:
- ... CYP19 is the single copy gene encoding for the estrogen synthetic enzyme aromatase. Alternate splicing of the promoter is the regulatory mechanism of this gene. In the brain, estrogen is synthesized in neuronal and glial cells and the gene is mainly regulated by the alternate promoter PI.f. The hormone produced in this vicinity has been associated with maintaining normal brain functions. Previousl ...
- DOI:
- 10.1016/j.mce.2017.05.029
- https://doi.org/10.1016/j.mce.2017.05.029
- Author:
- Yuan Gao; Yingning Sun; Kui Duan; Hongyan Shi; Shouzhi Wang; Hui Li; Ning Wang
- Source:
- Animal genetics 2015 v.46 no.4 pp. 410-417
- ISSN:
- 0268-9146
- Subject:
- DNA methylation; abdominal fat; adipocytes; adipogenesis; adipose tissue; bone formation; bone marrow; chickens; correlation; gene expression; lipid content; messenger RNA; mice; promoter regions; reverse transcriptase polymerase chain reaction; stromal cells
- Abstract:
- ... CCAAT/enhancer‐binding protein (C/EBP), alpha (CEBPA) is a master regulator of adipogenesis and, together with peroxisome proliferator‐activated receptor gamma (PPARG), plays a critical role in adipocyte differentiation. Previous studies have demonstrated that CEBPA is regulated by DNA methylation and involved in the osteogenesis and adipogenesis of mouse C3H10T1/2 and bone marrow stromal cells. H ...
- DOI:
- 10.1111/age.12326
- https://doi.org/10.1111/age.12326