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You searched for: Subject term DNA methylation Remove constraint Subject term: DNA methylation Subject term bisphenol A Remove constraint Subject term: bisphenol A
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1. Aberrant DNA methylation at Igf2–H19 imprinting control region in spermatozoa upon neonatal exposure to bisphenol A and its association with post implantation loss

Author:
Tanvi Doshi; Criselle D’souza; Geeta Vanage
Source:
Molecular biology reports 2013 v.40 no.8 pp. 4747-4757
ISSN:
0301-4851
Subject:
DNA methylation; adulthood; bisphenol A; epigenetics; gene expression; gene expression regulation; genes; male fertility; males; messenger RNA; pups; rats; sires; spermatozoa
Abstract:
... Bisphenol A (BPA) is an estrogenic compound commonly used in manufacture of various consumer products. Earlier studies from our group have demonstrated that neonatal exposure of male rats to BPA causes decrease in sperm count and motility, increase in post implantation loss, ultimately leading to subfertility during adulthood. One of the factors contributing for post implantation loss is altered m ...
DOI:
10.1007/s11033-013-2571-x

2. Association between prenatal bisphenol a exposure and promoter hypermethylation of CAPS2, TNFRSF25, and HKR1 genes in cord blood

Author:
Xiuxia Song; Xiaoyu Zhou; Fen Yang; Hong Liang; Ziliang Wang; Runsheng Li; Maohua Miao; Wei Yuan
Source:
Environmental research 2020 v.190 pp. 109996
ISSN:
0013-9351
Subject:
DNA methylation; bisphenol A; blood; epigenetics; epigenome; high performance liquid chromatography; maternal exposure; nervous system; polymerase chain reaction; progeny; regression analysis; research; signal transduction; urine
Abstract:
... In utero exposure to bisphenol A (BPA) in early stages of development has been reported to exert adverse health effects on offspring later in life. Epigenetic alterations, particularly DNA methylation, may be one plausible biological mechanism involved. We examined the association between maternal BPA exposure and DNA methylation in cord blood. We randomly selected 96 paired samples of maternal ur ...
DOI:
10.1016/j.envres.2020.109996

3. BDNF as a potential mediator between childhood BPA exposure and behavioral function in adolescent boys from the INMA-Granada cohort

Author:
Vicente Mustieles; Andrea Rodríguez-Carrillo; Fernando Vela-Soria; Shereen Cynthia D'Cruz; Arthur David; Fatima Smagulova; Antonio Mundo-López; Alicia Olivas-Martínez; Iris Reina-Pérez; Nicolás Olea; Carmen Freire; Juan P. Arrebola; Mariana F. Fernández
Source:
Science of the total environment 2022 v.803 pp. 150014
ISSN:
0048-9697
Subject:
DNA methylation; adolescence; adolescents; adverse outcome pathways; biomarkers; bisphenol A; blood serum; childhood; children; creatinine; dose response; environment; environmental monitoring; exons; humans; regression analysis; toxicology; urine; Spain
Abstract:
... Bisphenol A (BPA) exposure has been linked to altered behavior in children. Within the European Human Biomonitoring Initiative (HBM4EU), an adverse outcome pathway (AOP) network was constructed supporting the mechanistic link between BPA exposure and brain-derived neurotrophic factor (BDNF).To test this toxicologically-based hypothesis in the prospective INMA-Granada birth cohort (Spain).BPA conce ...
DOI:
10.1016/j.scitotenv.2021.150014

4. BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis

Author:
Wen Xue; Xiong Yao; Geng Ting; Jin Ling; Liu Huimin; Qiao Yuan; Zhou Chun; Zhang Ming; Zhang Yuanzhen
Source:
Environmental pollution 2021 v.268 pp. 115748
ISSN:
0269-7491
Subject:
DNA methylation; WD40 repeats; bisphenol A; endometriosis; endometrium; epigenetics; estrogen receptors; exons; humans; lysine; mice; models; pathogenesis; pollution
Abstract:
... Overexpression of estrogen receptor β (ERβ) in endometrium contributes to endometriosis (EM) pathogenesis. Trimethylation of the H3 lysine (K) 4 (H3K4me3) in promoters is strongly correlated with gene expression. This study aimed to explore the effects of bisphenol A (BPA) exposure on EM development from the perspective of the regulation of ERβ expression in eutopic endometrium via the H3K4me3-rel ...
DOI:
10.1016/j.envpol.2020.115748

5. BPA's transgenerational disturbance to transcription of ovarian steroidogenic genes in rare minnow Gobiocypris rarus via DNA and histone methylation

Author:
Long Zhu; Yan Liu; Xue Xue; Cong Yuan; Zaizhao Wang
Source:
Science of the total environment 2021 v.762 pp. 143055
ISSN:
0048-9697
Subject:
DNA; DNA methylation; Gobiocypris rarus; animal reproduction; bisphenol A; endocrine-disrupting chemicals; environment; epigenetics; histones; methyltransferases; minnows; oocytes; ovarian development; progeny
Abstract:
... As a well-known estrogenic endocrine disruptor, bisphenol A (BPA) is of utmost concern since it is reported with harmful effects on animal reproduction. However, the adverse effects on progeny after parental BPA exposure are largely unknown in fishes. To investigate the epigenetic effects of BPA on progeny gonadal development, parental rare minnow (Gobiocypris rarus) were exposed to BPA (15 μg L⁻¹ ...
DOI:
10.1016/j.scitotenv.2020.143055

6. BPA-induced DNA hypermethylation of the master mitochondrial gene PGC-1α contributes to cardiomyopathy in male rats

Author:
Ying Jiang; Wei Xia; Jie Yang; Yingshuang Zhu; Huailong Chang; Juan Liu; Wenqian Huo; Bing Xu; Xi Chen; Yuanyuan Li; Shunqing Xu
Source:
Toxicology 2015 v.329 pp. 21-31
ISSN:
0300-483X
Subject:
DNA; adenosine triphosphate; biogenesis; bisphenol A; cardiac output; cardiomyocytes; cardiomyopathy; chronic exposure; corn oil; endocrine-disrupting chemicals; gene expression; genes; hypertrophy; long term effects; males; membrane potential; messenger RNA; methylation; mitochondria; mitochondrial membrane; rats
Abstract:
... Implication of environmental endocrine disruptors, such as bisphenol A (BPA), on the development of cardiopathy has been poorly investigated. The aim of the study was to investigate the effects of long-term exposure to BPA at the reference dose on the myocardium of rats, and the underlying mechanisms.Male rats received corn oil or 50μg/kg/day of BPA since delactation. At 24 and 48 weeks (wk), card ...
DOI:
10.1016/j.tox.2015.01.001

7. Bisphenol A (BPA) in the serum of pet dogs following short-term consumption of canned dog food and potential health consequences of exposure to BPA

Author:
Zoe L. Koestel; Robert C. Backus; Kaoru Tsuruta; William G. Spollen; Sarah A. Johnson; Angela B. Javurek; Mark R. Ellersieck; Charles E. Wiedmeyer; Kurunthachalam Kannan; Jingchuan Xue; Nathan J. Bivens; Scott A. Givan; Cheryl S. Rosenfeld
Source:
Science of the total environment 2017 v.579 pp. 1804-1814
ISSN:
0048-9697
Subject:
DNA methylation; bicarbonates; bioaccumulation; bisphenol A; blood chemistry; blood serum; correlation; cortisol; diet; dietary exposure; dogs; endocrine-disrupting chemicals; feces; hematology; human health; intestinal microorganisms; lymphocytes; microbiome; pet foods; wildlife
Abstract:
... Bisphenol A (BPA) is a widely present endocrine disruptor chemical found in many household items. Moreover, this chemical can bioaccumulate in various terrestrial and aquatic sources; thereby ensuring continual exposure of animals and humans. For most species, including humans, diet is considered the primary route of exposure. However, there has been little investigation whether commercial-brands ...
DOI:
10.1016/j.scitotenv.2016.11.162

8. Bisphenol A and benzophenone-3 exposure alters milk protein expression and its transcriptional regulation during functional differentiation of the mammary gland in vitro

Author:
Gabriela A. Altamirano; Ayelen L. Gomez; Gonzalo Schierano-Marotti; Mónica Muñoz-de-Toro; Horacio A. Rodriguez; Laura Kass
Source:
Environmental research 2020 v.191 pp. 110185
ISSN:
0013-9351
Subject:
DNA methylation; UV filters; benzophenones; beta-casein; bisphenol A; direct contact; estrogen receptors; ethanol; females; gene expression; genes; glucocorticoid receptors; lactalbumin; mammary development; mammary glands; milk; models; organoids; plasticizers; progesterone receptors; prolactin receptors; protein synthesis; research; transcription (genetics)
Abstract:
... The plastic monomer and plasticizer bisphenol A (BPA), and the UV-filter benzophenone-3 (BP3) have been shown to have estrogenic activities that could alter mammary gland development. Our aim was to analyze whether BPA or BP3 direct exposure affects the functional differentiation of the mammary gland using an in vitro model. Mammary organoids were obtained and isolated from 8 week-old virgin femal ...
DOI:
10.1016/j.envres.2020.110185

9. Bisphenol A damages testicular junctional proteins transgenerationally in mice

Author:
Elikanah Olusayo Adegoke; Md Saidur Rahman; Shereen Amjad; Won-Ki Pang; Do-Yeal Ryu; Yoo-Jin Park; Myung-Geol Pang
Source:
Environmental pollution 2022 v.302 pp. 119067
ISSN:
0269-7491
Subject:
DNA methylation; bisphenol A; body weight; corn oil; endocrine-disrupting chemicals; estrogens; histology; male fertility; males; mitogen-activated protein kinase; pollution; spermatogenesis; spermatozoa; testes
Abstract:
... Testicular junctions are pivotal to male fertility and regulated by constituent proteins. Increasing evidence suggests that environmental chemicals, including bisphenol A (BPA), may impact these proteins, but whether the impacts persist for generations is not yet known. Here, we investigate the effect of BPA (a ubiquitous endocrine-disrupting chemical) on testis and sperm functions and whether the ...
DOI:
10.1016/j.envpol.2022.119067

10. Bisphenol A disturbed the lipid metabolism mediated by sterol regulatory element binding protein 1 in rare minnow Gobiocypris rarus

Author:
Yongjing Guan; Ting Zhang; Jiafa He; Jia Jia; Long Zhu; Zaizhao Wang
Source:
Aquatic toxicology 2019 v.207 pp. 179-186
ISSN:
0166-445X
Subject:
DNA methylation; Gobiocypris rarus; acetyl-CoA carboxylase; aquatic environment; beta oxidation; binding proteins; bisphenol A; carnitine palmitoyltransferase; endocrine-disrupting chemicals; fatty acids; fatty-acid synthase; females; genes; lipid content; minnows; regulatory sequences; sterols
Abstract:
... Bisphenol A (BPA), a representative endocrine disrupting compound, exists ubiquitously in the aquatic environment. Several studies on fish have validated the role of BPA in the lipid metabolism. However, the action mechanisms of BPA on lipid metabolism have been little studied. To clarify how BPA regulates lipid metabolism, Gobiocypris rarus were exposed to 15 μg/L BPA for 3 and 6 weeks. Results s ...
DOI:
10.1016/j.aquatox.2018.12.011

11. Bisphenol A disturbs hepatic apolipoprotein A1 expression and cholesterol metabolism in rare minnow Gobiocypris rarus

Author:
Zhu Zhu; Jian Ju; Meng Zhang; Hui Yang; Wenzhi Wei; Yingying Zhang
Source:
Comparative biochemistry and physiology 2022 v.252 pp. 109239
ISSN:
1532-0456
Subject:
DNA methylation; Gobiocypris rarus; adults; apolipoprotein A-I; aquatic environment; bisphenol A; cholesterol; cholesterol metabolism; high density lipoprotein; lipid metabolism disorders; males; minnows; plasticizers; promoter regions
Abstract:
... Bisphenol A (BPA) is a well-known plasticizer, which is widely distributed in the aquatic environment. Lots of studies showed that BPA could lead to lipid metabolism disorder in fish, but few studies studied the mechanism from the perspective of lipid transport. Apolipoprotein A1 (ApoA1) is the main component of high-density lipoprotein (HDL), and plays important roles in reverse cholesterol trans ...
DOI:
10.1016/j.cbpc.2021.109239

12. Bisphenol A disturbs transcription of steroidogenic genes in ovary of rare minnow Gobiocypris rarus via the abnormal DNA and histone methylation

Author:
Yan Liu; Lihong Wang; Long Zhu; Benhui Ran; Zaizhao Wang
Source:
Chemosphere 2020 v.240 pp. 124935
ISSN:
0045-6535
Subject:
DNA; DNA methylation; Gobiocypris rarus; bisphenol A; chronic exposure; epigenetics; estradiol; gene expression; gene expression regulation; genes; histones; messenger RNA; minnows; oocytes; ovarian development; rare species; reproduction; steroidogenesis; toxicity; transcription (genetics)
Abstract:
... Increasing studies have established the toxic effects of BPA on development and reproduction in animals. In present study, we investigated epigenetic effects on the transcription of several ovarian steroidogenic genes in rare minnows Gobiocypris rarus after BPA exposure at 15 μgL⁻¹ for 21, 42 and 63 d. Results showed that short term BPA exposure (21 d) caused significant increase of both estradiol ...
DOI:
10.1016/j.chemosphere.2019.124935

13. Bisphenol A exposure induces cholesterol synthesis and hepatic steatosis in C57BL/6 mice by down-regulating the DNA methylation levels of SREBP-2

Author:
Qingrong Li; Hongmin Zhang; Jun Zou; Haiyan Mai; Dongfang Su; Xiang Feng; Dan Feng
Source:
Food and chemical toxicology 2019 pp. -
ISSN:
0278-6915
Subject:
DNA methylation; beverages; bisphenol A; cholesterol; coenzyme A; diet; fatty liver; food storage; gene expression; gene expression regulation; hydroxymethylglutaryl-CoA reductases; liver; males; mice; plasticizers; stearoyl-CoA desaturase
Abstract:
... Bisphenol A (BPA), a major plasticizers that are commonly used for lining of beverage or food-storage containers, has been shown to increase cholesterol levels with molecular mechanism not clear. The present study was aimed to investigate the effects of BPA exposure on liver cholesterol synthesis and hepatic steatosis in male C57BL/6 mice and its underlying mechanisms. Male C57BL/6 mice were expos ...
DOI:
10.1016/j.fct.2019.110786

14. Bisphenol A exposure modifies DNA methylation of imprint genes in mouse fetal germ cells

Author:
Xi-Feng Zhang; Lian-Jun Zhang; Yan-Ni Feng; Bo Chen; Yan-Min Feng; Gui-Jin Liang; Lan Li; Wei Shen
Source:
Molecular biology reports 2012 v.39 no.9 pp. 8621-8628
ISSN:
0301-4851
Subject:
DNA methylation; bisphenol A; body weight; females; gene expression; genes; germ cells; humans; males; messenger RNA; mice; risk
Abstract:
... Bisphenol A (BPA) is an estrogenic environmental toxin widely used for the production of plastics. Human frequent exposure to this chemical has been proposed to be a potential public health risk. The objective of this study was to assess the effects of BPA on DNA methylation of imprinting genes in fetal mouse germ cell. Pregnant mice were treated with BPA at doses of 0, 40, 80 and 160 μg BPA/kg bo ...
DOI:
10.1007/s11033-012-1716-7

15. Bisphenol A regulates apolipoprotein A1 expression through estrogen receptors and DNA methlylation and leads to cholesterol disorder in rare minnow testis

Author:
Yingying Zhang; Meng Zhang; Zhu Zhu; Hui Yang; Wenzhi Wei; Bichun Li
Source:
Aquatic toxicology 2021 v.241 pp. 105999
ISSN:
0166-445X
Subject:
DNA; DNA methylation; Gobiocypris rarus; adults; apolipoprotein A-I; aquatic environment; bisphenol A; estrogens; high density lipoprotein cholesterol; lipid metabolism; males; minnows; plasticizers; spermatogenesis; spermatozoa; testes; toxicology
Abstract:
... Bisphenol A (BPA) is a well-known plasticizer that widely distributed in the aquatic environment. BPA has many adverse effects on reproduction. However, few studies have investigated the mechanism of BPA affecting reproduction from the perspective of lipid metabolism. Apolipoprotein A1 (ApoA1) is the major component of high-density lipoprotein (HDL), and plays critical roles in reverse cholesterol ...
DOI:
10.1016/j.aquatox.2021.105999

16. Bisphenol A-associated alterations in DNA and histone methylation affects semen quality in rare minnow Gobiocypris rarus

Author:
Long Zhu; Cong Yuan; Mingrong Wang; Yan Liu; Zaizhao Wang; Mohamed M. Seif
Source:
Aquatic toxicology 2020 v.226 pp. 105580
ISSN:
0166-445X
Subject:
DNA; DNA methylation; DNA methyltransferase; Gobiocypris rarus; adults; bisphenol A; blood; endocrine system; endocrine-disrupting chemicals; epigenetics; histones; males; minnows; reproduction; reproductive toxicology; semen quality; sperm quality; spermatids; spermatocytes; toxicity
Abstract:
... Bisphenol A (BPA), a well-known estrogenic endocrine disruptor, is ubiquitously present in the environment, possessing the potential to interfere with the reproductive endocrine system in male mammals. However, there are limited studies on the reproductive toxicity in male aquatic animals associated with epigenetic modifications. In order to evaluate the potential effects of BPA on reproduction an ...
DOI:
10.1016/j.aquatox.2020.105580

17. Bisphenol A: What lies beneath its induced diabetes and the epigenetic modulation?

Author:
Soheila Rahmani; Nazila Pour Khalili; Fazlullah Khan; Shokoufeh Hassani; Elmira Ghafour-Boroujerdi; Mohammad Abdollahi
Source:
Life sciences 2018 v.214 pp. 136-144
ISSN:
0024-3205
Subject:
DNA methylation; adipocytes; animals; bisphenol A; demethylation; endocrine-disrupting chemicals; epigenetics; estrogenic properties; fatty liver; genes; glucose; histones; homeostasis; insulin; islets of Langerhans; lipids; liver; microRNA; noninsulin-dependent diabetes mellitus; obesity; pollution; skeletal muscle; toxicity
Abstract:
... Nowadays, endocrine disrupting chemical pollution has become one of the major concerns due to the potential role of these chemicals in provoking endocrine disorders especially type 2 diabetes. As a widespread endocrine disrupting chemical, Bisphenol A, with modest estrogenic activity can exert its detrimental effects in the different organs involved in type 2 diabetes such as pancreas, liver, adip ...
DOI:
10.1016/j.lfs.2018.10.044

18. Bisphenol S induced epigenetic and transcriptional changes in human breast cancer cell line MCF-7

Author:
Wei Huang; Chao Zhao; Huan Zhong; Shoudong Zhang; Yiji Xia; Zongwei Cai
Source:
Environmental pollution 2019 v.246 pp. 697-703
ISSN:
0269-7491
Subject:
DNA methylation; bioactive properties; bisphenol A; bisphenol S; breast neoplasms; disease course; epigenetics; extracellular matrix; gene expression regulation; gene ontology; genes; human cell lines; human diseases; humans; models; neoplasm cells; signal transduction; transcription (genetics); transposons
Abstract:
... In recent years, concerns about using Bisphenol A (BPA) in daily consume products and its effects in many chronic human diseases have prompted the removal of BPA. However, the widely used BPA alternatives, including Bisphenol S (BPS), have a high structural similarity with BPA, suggesting that they may have similar biological effects towards human beings. Indeed, BPS was also found to have endocri ...
DOI:
10.1016/j.envpol.2018.12.084

19. Breast cancer proliferation and deterioration-associated metabolic heterogeneity changes induced by exposure of bisphenol S, a widespread replacement of bisphenol A

Author:
Chao Zhao; Ting Yong; Yinbin Zhang; Yu Xiao; Yaofeng Jin; Chang Zheng; Takashi Nirasawa; Zongwei Cai
Source:
Journal of hazardous materials 2021 v.414 pp. 125391
ISSN:
0304-3894
Subject:
DNA methylation; bisphenol A; bisphenol S; body weight; breast neoplasms; carcinogenesis; cell proliferation; chromosomal instability; dose response; lipidomics; mass spectrometry; metabolism; metastasis; molecular biology; nucleic acids; proteomics
Abstract:
... Exposure to bisphenol A (BPA) is considered to be associated with the increased incidence of breast cancer. As a widespread replacement of BPA, the effect of bisphenol S (BPS) on breast tumor programming has not been studied. We reported that BPS exposure significantly promoted proliferation and deterioration of breast tumor by nonmonotonic dose response. The mechanisms were investigated by molecu ...
DOI:
10.1016/j.jhazmat.2021.125391

20. Chronic exposure to Bisphenol A resulted in alterations of reproductive functions via immune defense, oxidative damage and disruption DNA/histone methylation in male rare minnow Gobiocypris rarus

Author:
Long Zhu; Lihong Wang; Xiaoteng Fan; Chenglong Dong; Gaoxue Wang; Zaizhao Wang
Source:
Aquatic toxicology 2021 v.236 pp. 105849
ISSN:
0166-445X
Subject:
DNA; DNA methylation; Gobiocypris rarus; adults; bisphenol A; catalase; chronic exposure; histones; hydrogen peroxide; immune response; inflammation; males; minnows; oxidative stress; reproduction; reproductive toxicology; sperm quality; transcriptomics
Abstract:
... Bisphenol A (BPA) is a widely used chemical that represents a reproductive hazard in fish. However, the molecular pathways mediating reproductive toxicity under chronic BPA exposure remain unclear. To study the reproductive hazards associated with chronic BPA exposure, adult male rare minnows (Gobiocypris rarus) were treated with 15 μg L ⁻ ¹ and 225 μg L ⁻ ¹ BPA for 90 days. Results showed that ch ...
DOI:
10.1016/j.aquatox.2021.105849

21. Cuscuta chinensis flavonoids down-regulate the DNA methylation of the H19/Igf2 imprinted control region and estrogen receptor alpha promoter of the testis in bisphenol A exposed mouse offspring

Author:
Yuanyuan Wei; Chao Han; Shuying Li; Yuqing Cui; Yongzhan Bao; Wanyu Shi
Source:
Food & function 2020 v.11 no.1 pp. 787-798
ISSN:
2042-650X
Subject:
Cuscuta; DNA; DNA methylation; adults; bisphenol A; blood serum; detection; dietary supplements; endocrine-disrupting chemicals; epigenetics; estradiol; estrogen receptors; flavonoids; genes; males; methyltransferases; mice; pregnancy; progeny; reproductive disorders; testes; testicular development; testosterone
Abstract:
... Exposure to the emerging contaminant bisphenol A (BPA) is ubiquitous and associated with reproductive disorders. The BPA effect as an endocrine disruptor is widely known but other mechanisms underlying developmental disease, such as epigenetic modifications, still remain unclear. The objective of this study was to investigate whether Cuscuta chinensis flavonoids (CCFs) can be used as a dietary sup ...
DOI:
10.1039/c9fo02770j

22. DNA methylation of BDNF as a biomarker of early-life adversity

Author:
Marija Kundakovic; Kathryn Gudsnuk; Julie B. Herbstman; Deliang Tang; Frederica P. Perera; Frances A. Champagne
Source:
Proceedings of the National Academy of Sciences of the United States of America 2015 v.112 no.22 pp. 6807-6813
ISSN:
0027-8424
Subject:
DNA methylation; animal behavior; autism; biomarkers; bisphenol A; blood; environmental exposure; environmental models; epigenetics; exposure models; gene expression; genes; hippocampus; human behavior; humans; long term effects; mice; neurodevelopment; patients; risk; schizophrenia; transcription (genetics)
Abstract:
... Early-life adversity increases the risk for psychopathology in later life. The underlying mechanism(s) is unknown, but epigenetic variation represents a plausible candidate. Early-life exposures can disrupt epigenetic programming in the brain, with lasting consequences for gene expression and behavior. This evidence is primarily derived from animal studies, with limited study in humans due to inac ...
DOI:
10.1073/pnas.1408355111
PubMed:
25385582
PubMed Central:
PMC4460453

23. DNA-based hybridization chain reaction amplification for assaying the effect of environmental phenolic hormone on DNA methyltransferase activity

Author:
Zhenning Xu; Huanshun Yin; Yunxiang Han; Yunlei Zhou; Shiyun Ai
Source:
Analytica chimica acta 2014 v.829 pp. 9-14
ISSN:
0003-2670
Subject:
1-naphthol; DNA; DNA methylation; analytical chemistry; antineoplastic activity; biotin; bisphenol A; carcinogenesis; daunorubicin; electrochemistry; electrodes; fluorouracil; gold; hybridization; methyltransferases; phosphates; polymers
Abstract:
... In this work, a novel electrochemical protocol with signal amplification for determination of DNA methylation and methyltransferase activity using DNA-based hybridization chain reaction (HCR) was proposed. After the gold electrode was modified with dsDNA, it was treated with M.SssI MTase, HpaII endonuclease, respectively. And then the HCR was initiated by the target DNA and two hairpin helper DNAs ...
DOI:
10.1016/j.aca.2014.04.024

24. Deleterious effects of endocrine disruptors are corrected in the mammalian germline by epigenome reprogramming

Author:
Khursheed Iqbal; Diana A Tran; Arthur X Li; Charles Warden; Angela Y Bai; Purnima Singh; Xiwei Wu; Gerd P Pfeifer; Piroska E Szabó
ISSN:
1465-6906
Subject:
DNA methylation; bisphenol A; endocrine-disrupting chemicals; environmental exposure; epigenetics; females; genes; genomics; germ cells; inheritance (genetics); males; mice; phthalates; pregnancy; transcription (genetics); vinclozolin
Abstract:
... BACKGROUND: Exposure to environmental endocrine-disrupting chemicals during pregnancy reportedly causes transgenerationally inherited reproductive defects. We hypothesized that to affect the grandchild, endocrine-disrupting chemicals must alter the epigenome of the germ cells of the in utero-exposed G1 male fetus. Additionally, to affect the great-grandchild, the aberration must persist in the ger ...
DOI:
10.1186/s13059-015-0619-z
PubMed:
25853433
PubMed Central:
PMC4376074

25. Developmental exposure to bisphenol A alters expression and DNA methylation of Fkbp5, an important regulator of the stress response

Author:
Efthymia Kitraki; Ivan Nalvarte; Ali Alavian-Ghavanini; Joëlle Rüegg
Source:
Molecular and Cellular Endocrinology 2015 v.417 pp. 191-199
ISSN:
0303-7207
Subject:
DNA methylation; antagonists; bisphenol A; children; endocrine-disrupting chemicals; epigenetics; estrogen receptors; glucocorticoid receptors; hippocampus; hypothalamus; males; rats; stress response
Abstract:
... Bisphenol A (BPA), an abundant endocrine disruptor, affects stress-responsiveness and related behaviors in children. In rats, perinatal BPA exposure modifies stress response in pubertal offspring via unknown mechanisms. Here we examined possible epigenetic modifications in the glucocorticoid receptor gene and its regulator Fkbp5 in hypothalamus and hippocampus of exposed offspring. We found increa ...
DOI:
10.1016/j.mce.2015.09.028

26. Differential methylation of genes in the human placenta associated with bisphenol A exposure

Author:
Xiuxia Song; Ziliang Wang; Zhaofeng Zhang; Maohua Miao; Junwei Liu; Min Luan; Jing Du; Hong Liang; Wei Yuan
Source:
Environmental research 2021 v.200 pp. 111389
ISSN:
0013-9351
Subject:
DNA methylation; bisphenol A; cohort studies; confidence interval; high performance liquid chromatography; high-throughput nucleotide sequencing; humans; maternal exposure; placenta; progeny; research; urine
Abstract:
... Prenatal exposure to bisphenol A (BPA) is associated with numerous adverse health outcomes among offspring. Although DNA methylation is considered one of the underlying causes of these associations, few studies have focused on the association between prenatal BPA exposure and DNA methylation in the human placenta. In this study, we examined the association between prenatal BPA exposure and DNA met ...
DOI:
10.1016/j.envres.2021.111389

27. Discrepant dose responses of bisphenol A on oxidative stress and DNA methylation in grass carp ovary cells

Author:
Xiaoteng Fan; Tingting Hou; Jia Jia; Kui Tang; Xuefeng Wei; Zaizhao Wang
Source:
Chemosphere 2020 v.248 pp. 126110
ISSN:
0045-6535
Subject:
Ctenopharyngodon idella; DNA; DNA methylation; biosynthesis; bisphenol A; cell proliferation; cytotoxicity; fish; genotoxicity; glutathione; hormesis; malondialdehyde; methyltransferases; oxidation; oxidative stress; reactive oxygen species; viability
Abstract:
... Bisphenol A (BPA), is a common contaminant in diverse environmental compartments and its endocrine disruptive effect on living organisms has been widely reported. Further works are still required to facilitate the research on cytotoxicity and genotoxicity. In the present study, grass carp ovary (GCO) cells were used to investigate cellular oxidative stress and genomic DNA methylation under BPA exp ...
DOI:
10.1016/j.chemosphere.2020.126110

28. Effect of prenatal bisphenol A exposure on early childhood body mass index through epigenetic influence on the insulin-like growth factor 2 receptor (IGF2R) gene

Author:
Yoon-Jung Choi; Young Ah Lee; Yun-Chul Hong; Jinwoo Cho; Kyung-Shin Lee; Choong Ho Shin; Bung-Nyun Kim; Johanna Inhyang Kim; Soo Jin Park; Hans Bisgaard; Klaus Bønnelykke; Youn-Hee Lim
Source:
Environment international 2020 v.143 pp. 105929
ISSN:
0160-4120
Subject:
DNA methylation; bisphenol A; body mass index; childhood; childhood obesity; confidence interval; creatinine; environment; epigenetics; genes; humans; insulin-like growth factor II; maternal exposure; standard deviation; statistical models
Abstract:
... Epigenetic mechanisms have been suggested to play a role in the link between in utero exposure to bisphenol A (BPA) and pediatric obesity; however, there is little evidence regarding this mechanism in humans. We obtained data on obesity-associated CpG sites from a previous epigenome-wide association study, and then examined whether methylation at those CpG sites was influenced by prenatal BPA expo ...
DOI:
10.1016/j.envint.2020.105929

29. Effects of bisphenol-A and folic acid on growth, reproductive development, and DNA methylation in snapdragons (Antirrhinum majus)

Author:
Kayoung Heo; Glenys Gibson; Rodger Evans
Source:
Botany 2019 v.97 no.2 pp. 149-160
ISSN:
1916-2804
Subject:
Antirrhinum majus; DNA methylation; bisphenol A; environmental protection; epigenetics; flowering; flowers; folic acid; mice; plant growth; plant height; plastics; seedlings
Abstract:
... Bisphenol-A (BPA), used in the production of polycarbonate plastics, exerts complex effects on the development of organisms and on their epigenomes as a methylation disruptor. BPA is of concern due to its ubiquity in the environment. In contrast, folic acid can promote plant growth and has been shown to correct the methyl-disrupting effects of BPA in mice. We investigated the effects of prolonged ...
DOI:
10.1139/cjb-2018-0116

30. Effects of maternal methyl donor on the pork characteristics of offspring pigs with prenatal exposure to bisphenol A

Author:
Y. Zhuo; J. Wang; H. Liu; D. Mou; T. Adebowale; L. Che; Z. Fang; S. Xu; G. Liu; Y. Lin; B. Feng; N. Abdullah Al-Dhabi; J. Li; V. Duraipandiyan; D. Wu
Source:
Animal 2018 v.12 no.6 pp. 1306-1315
ISSN:
1751-732X
Subject:
DNA methylation; bisphenol A; dietary supplements; enzyme activity; glycogen; glycogen (starch) synthase; glycolysis; lactate dehydrogenase; lactic acid; longissimus muscle; maternal exposure; maternal nutrition; messenger RNA; pH; pork; pork quality; pregnancy; progeny; sows; swine finishing
Abstract:
... To explore the effects of maternal nutrition on offspring muscle characteristics, a total of 56 sows were assigned to one of the four dietary groups during gestation: control (CON), or control diets supplemented with methyl donor (MET), bisphenol A (BPA), and combined BPA and MET (BPA+MET). Compared with CON offspring, MET offspring showed a higher meat redness value, but lower glycogen content in ...
DOI:
10.1017/S175173111700252X
PubMed:
29065941

31. Effects of oral exposure to bisphenol A on gene expression and global genomic DNA methylation in the prostate, female mammary gland, and uterus of NCTR Sprague-Dawley rats

Author:
Luísa Camacho; Mallikarjuna S. Basavarajappa; Ching-Wei Chang; Tao Han; Tetyana Kobets; Igor Koturbash; Gordon Surratt; Sherry M. Lewis; Michelle M. Vanlandingham; James C. Fuscoe; Gonçalo Gamboa da Costa; Igor P. Pogribny; K. Barry Delclos
Source:
Food and chemical toxicology 2015 v.81 pp. 92-103
ISSN:
0278-6915
Subject:
DNA; DNA methylation; adverse effects; bisphenol A; body weight; dose response; epoxides; estradiol; estrogen receptors; females; gene expression; genes; mammary glands; manufacturing; oral exposure; pregnancy; rats; resins; tissues; toxicity; toxicology; uterus
Abstract:
... Bisphenol A (BPA), an industrial chemical used in the manufacture of polycarbonate and epoxy resins, binds to the nuclear estrogen receptor with an affinity 4–5 orders of magnitude lower than that of estradiol. We reported previously that “high BPA” [100,000 and 300,000 µg/kg body weight (bw)/day], but not “low BPA” (2.5–2700 µg/kg bw/day), induced clear adverse effects in NCTR Sprague-Dawley rats ...
DOI:
10.1016/j.fct.2015.04.009
PubMed:
25862956
PubMed Central:
PMC4487663

32. Embryonic Exposure to Low Concentrations of Bisphenol A and S Altered Genes Related to Pancreatic β-Cell Development and DNA Methyltransferase in Zebrafish

Author:
Eric Gyimah; Xing Dong; Hai Xu; Zhen Zhang; John Kenneth Mensah
Source:
Archives of environmental contamination and toxicology 2021 v.80 no.2 pp. 450-460
ISSN:
0090-4341
Subject:
DNA; DNA methylation; DNA methyltransferase; Danio rerio; bisphenol A; bisphenol S; developmental stages; diabetes mellitus; early development; epigenetics; gene expression; genes; glucose; insulin; pollution; toxicology
Abstract:
... Bisphenol A (BPA) and bisphenol S (BPS) are implicated in the development of metabolic disorders, such diabetes mellitus. However, the epigenetic mechanism underlying the pancreatic β-cell dysregulation for both BPA/BPS needs clarification. This exploratory study was designed to investigate whether embryonic exposure to low BPA/BPS concentrations impair early pancreatic β-cell differentiation as w ...
DOI:
10.1007/s00244-021-00812-8

33. Enhanced GSH synthesis by Bisphenol A exposure promoted DNA methylation process in the testes of adult rare minnow Gobiocypris rarus

Author:
Cong Yuan; Yingying Zhang; Yan Liu; Ting Zhang; Zaizhao Wang
Source:
Aquatic toxicology 2016 v.178 pp. 99-105
ISSN:
0166-445X
Subject:
DNA; DNA methylation; Gobiocypris rarus; adults; bisphenol A; epigenetics; gene expression; genes; glutathione; hydrogen peroxide; males; methyltransferases; minnows; proteins; testes
Abstract:
... DNA methylation is a commonly studied epigenetic modification. The mechanism of BPA on DNA methylation is poorly understood. The present study aims to explore whether GSH synthesis affects DNA methylation in the testes of adult male rare minnow Gobiocypris rarus in response to Bisphenol A (BPA). Male G. rarus was exposed to 1, 15 and 225μgL⿿1 BPA for 7 days. The levels of global DNA methylation, h ...
DOI:
10.1016/j.aquatox.2016.07.015

34. Environmental chemicals differentially affect epigenetic-related mechanisms in the zebrafish liver (ZF-L) cell line and in zebrafish embryos

Author:
Mélanie Blanc; Joëlle Rüegg; Nikolai Scherbak; Steffen H. Keiter
Source:
Aquatic toxicology 2019 pp. -
ISSN:
0166-445X
Subject:
DNA methylation; Danio rerio; bisphenol A; cell lines; coumarin; embryo (animal); embryogenesis; epigenetics; gene regulatory networks; genes; hepatocytes; histone code; histone demethylases; liver; long term effects; methoxychlor; models; perfluorocarbons; perfluorooctane sulfonic acid; permethrin; sulfonates; toxicology; transcription (genetics); vinclozolin
Abstract:
... A number of chemicals have been shown to affect epigenetic patterning and functions. Since epigenetic mechanisms regulate transcriptional networks, epigenetic changes induced by chemical exposure can represent early molecular events for long-term adverse physiological effects. Epigenetics has thus appeared as a research field of major interest within (eco)toxicological sciences. The present study ...
DOI:
10.1016/j.aquatox.2019.105272

35. Epigenetic effect of long-term bisphenol A exposure on human breast adenocarcinoma cells

Author:
Xiaoli Wang; Yunbo Wei; Tao Guo; Jinpeng Yuan; Rusong Zhao
Source:
Toxicological and environmental chemistry 2018 v.100 no.2 pp. 258-266
ISSN:
1029-0486
Subject:
DNA methylation; apoptosis; bisphenol A; breast neoplasms; breasts; cell growth; chemokines; environmental science; epigenetics; gene expression; genes; humans; neoplasm cells
Abstract:
... In this research, epigenetic effects of bisphenol A (BPA) on human breast cancer MCF-7 cells were analyzed. Genome-wide DNA methylation and gene expression were analyzed in MCF-7 cells exposed to BPA (10⁻⁵ and 10⁻⁶ mol/L for 5 weeks). No significant changes in the global level of 5-methyl-2′-deoxycytidine and 5-hydroxymethyl-2′-deoxycytidine were observed. DNA methylation profiling analysis indica ...
DOI:
10.1080/02772248.2018.1466143

36. Exposure to bisphenol A results in a decline in mouse spermatogenesis

Author:
Guo-Liang Zhang; Xi-Feng Zhang; Yan-Min Feng; Lan Li; Evanna Huynh; Xiao-Feng Sun; Zhong-Yi Sun; Wei Shen
Source:
Reproduction, fertility, and development 2013 v.25 no.6 pp. 847-859
ISSN:
1031-3613
Subject:
DNA methylation; bisphenol A; estrogen receptors; fur; genes; mice; progeny; semen; spermatogenesis; spermatozoa; testes
Abstract:
... Bisphenol A (BPA), a chemical used in many consumer products, interferes with the endocrine system of mammals, including humans. The aim of the present study was to investigate the effect of BPA on spermatogenesis and semen quality. The objective of this study was to assess the effects of BPA on mouse spermatogenesis. CD1 mice were used in all experiments. Mice were treated with different doses of ...
DOI:
10.1071/RD12159
PubMed:
22951085

37. Global and cyp19a1a gene specific DNA methylation in gonads of adult rare minnow Gobiocypris rarus under bisphenol A exposure

Author:
Yan Liu; Cong Yuan; Shu Chen; Yao Zheng; Yingying Zhang; Jiancao Gao; Zaizhao Wang
Source:
Aquatic toxicology 2014 v.156 pp. 10-16
ISSN:
0166-445X
Subject:
DNA; DNA methylation; Gobiocypris rarus; S-adenosylmethionine; adults; androgens; animal ovaries; aromatase; bisphenol A; cytosine; epigenetics; estrogens; females; gene expression; genes; males; messenger RNA; methyltransferases; minnows; reproductive toxicology; steroidogenesis; testes
Abstract:
... As a weak estrogenic chemical, bisphenol A (BPA) has been extensively studied for reproductive toxicity and the effects on the steroidogenesis. In the present study, we aim to explore the effects of BPA on epigenetic modification in rare minnow Gobiocypris rarus. We have detected the global and cyp19a1a gene specific DNA methylation in gonads of adult G. rarus under BPA exposure. The global DNA me ...
DOI:
10.1016/j.aquatox.2014.07.017

38. Global and region-specific post-transcriptional and post-translational modifications of bisphenol A in human prostate cancer cells

Author:
Ecem Fatma Karaman; Mine Caglayan; Serap Sancar-Bas; Cansu Ozal-Coskun; Pelin Arda-Pirincci; Sibel Ozden
Source:
Environmental pollution 2019 v.255 pp. 113318
ISSN:
0269-7491
Subject:
DNA methylation; biomarkers; bisphenol A; chromatin; cyclins; endocrine-disrupting chemicals; epigenetics; epoxides; gene expression; histone code; human diseases; human health; inhibitory concentration 50; neoplasm cells; neoplasm progression; plastics; post-translational modification; prostatic neoplasms; resins; risk; toxicity; tumor suppressor genes
Abstract:
... Bisphenol A (BPA), as synthetic monomer used in the production of polycarbonate plastic and epoxy resins, has endocrine disruptor properties and high risk on human health. Epigenetic alterations could act an important role in BPA-induced toxicity, but its mechanism has not been fully understood. We investigated the effects of BPA on gene expression of chromatin modifying enzymes, promoter methylat ...
DOI:
10.1016/j.envpol.2019.113318

39. High dose bisphenol A impairs hippocampal neurogenesis in female mice across generations

Author:
Young Jung Jang; Hee Ra Park; Tae Hyung Kim; Wook-Jin Yang; Jong-Joo Lee; Seon Young Choi; Shin Bi Oh; Eunjin Lee; Joo-Hong Park; Hyoung-Pyo Kim; Hyung Sik Kim; Jaewon Lee
Source:
Toxicology 2012 v.296 no.1-3 pp. 73-82
ISSN:
0300-483X
Subject:
DNA methylation; bisphenol A; cognition; epoxides; manufacturing; memory; mice; mitogen-activated protein kinase; neurogenesis; plastics; pregnancy; progeny; resins; toxicology
Abstract:
... Bisphenol A (BPA) is used as a monomer during the manufacture of polycarbonate plastics and epoxy resins. However, BPA adversely affects reproductive organ growth and development, and it has been proposed that the detrimental effects of BPA could extend to future generations. The present study was conducted to evaluate the transgenerational effects of BPA on hippocampal neurogenesis and neurocogni ...
DOI:
10.1016/j.tox.2012.03.007

40. Hypermethylation of estrogen receptor promoter region in adult testis of rats exposed neonatally to bisphenol A

Author:
Tanvi Doshi; Smita Salian Mehta; Vikas Dighe; Nafisa Balasinor; Geeta Vanage
Source:
Toxicology 2011 v.289 no.2-3 pp. 74-82
ISSN:
0300-483X
Subject:
DNA; DNA methylation; Western blotting; adulthood; adults; adverse effects; bisphenol A; epigenetics; epoxides; estrogen receptors; gene expression; manufacturing; methyltransferases; plastics; promoter regions; rats; resins; reverse transcriptase polymerase chain reaction; sesame oil; spermatogenesis; testes; toxicology
Abstract:
... BACKGROUND: Bisphenol A (BPA) is an estrogenic endocrine disruptor commonly used in manufacture of polycarbonate plastics and epoxy resins. Due to its ubiquitous presence in the environment, health concerns are increasing. Earlier studies from our group have shown that neonatal exposure of male rats to BPA affected spermatogenesis leading to impairment in fertility during adulthood. Further we als ...
DOI:
10.1016/j.tox.2011.07.011

41. In utero bisphenol A concentration, metabolism, and global DNA methylation across matched placenta, kidney, and liver in the human fetus

Author:
Muna S. Nahar; Chunyang Liao; Kurunthachalam Kannan; Craig Harris; Dana C. Dolinoy
Source:
Chemosphere 2015 v.124 pp. 54-60
ISSN:
0045-6535
Subject:
DNA methylation; active ingredients; bioactive properties; bisphenol A; etiology; fetus; gene expression; human development; humans; kidneys; liver; pharmacokinetics; placenta; pregnancy; tissues; urine
Abstract:
... While urine has been an easily accessible and feasible matrix for human biomonitoring, analytical measurements in internal tissues and organs can provide more accurate exposure assessments to understand disease etiology. This is especially important for the endocrine active compound, bisphenol A (BPA), where studies investigating internal doses at sensitive periods of human development are current ...
DOI:
10.1016/j.chemosphere.2014.10.071
PubMed:
25434263
PubMed Central:
PMC4297568

42. Male exposure to bisphenol a impairs spermatogenesis and triggers histone hyperacetylation in zebrafish testes

Author:
S. González-Rojo; M. Lombó; C. Fernández-Díez; M.P. Herráez
Source:
Environmental pollution 2019 v.248 pp. 368-379
ISSN:
0269-7491
Subject:
DNA hypermethylation; Danio rerio; acetylation; adults; antagonists; apoptosis; bisphenol A; chromatin; demethylation; embryogenesis; endocrine-disrupting chemicals; enzyme activity; enzyme-linked immunosorbent assay; epigenetics; females; gene expression; gene expression regulation; hatching; histone acetyltransferase; histones; humans; immunocytochemistry; in vitro studies; males; meiosis; messenger RNA; progeny; quantitative polymerase chain reaction; receptors; reverse transcriptase polymerase chain reaction; spermatocytes; spermatogenesis; spermatozoa; surface water; testes; transcriptomics; water pollution
Abstract:
... Bisphenol A (BPA) is an endocrine disruptor whose ubiquitous presence in the environment has been related with impairment of male reproduction. BPA can cause both transcriptomic and epigenetic changes during spermatogenesis. To evaluate the potential effects of male exposure to BPA, adult zebrafish males were exposed during spermatogenesis to doses of 100 and 2000 μg/L, which were reported in cont ...
DOI:
10.1016/j.envpol.2019.01.127

43. Maternal Methyl Donor Supplementation during Gestation Counteracts the Bisphenol A-Induced Impairment of Intestinal Morphology, Disaccharidase Activity, and Nutrient Transporters Gene Expression in Newborn and Weaning Pigs

Author:
Hong Liu; Jun Wang; Daolin Mou; Lianqiang Che; Zhengfeng Fang; Bin Feng; Yan Lin; Shengyu Xu; Jian Li; De Wu
Source:
Nutrients 2017 v.9 no.5 pp. -
ISSN:
2072-6643
Subject:
DNA; DNA methylation; Yorkshire (swine breed); beta-galactosidase; betaine; bisphenol A; choline; diet; digestibility; enzyme activity; folic acid; gene expression; gene expression regulation; ileum; intestinal absorption; jejunum; landraces; maternal exposure; methylenetetrahydrofolate reductase; models; neonates; peptide transporters; pregnancy; progeny; sows; sucrose alpha-glucosidase; transferases; villi; vitamin B12; weaning
Abstract:
... This study was conducted to explore whether exposure to bisphenol A (BPA) during pregnancy could change intestinal digestion and absorption function in offspring using pigs as a model, and whether methyl donor (MET) could counteract the BPA-induced impacts. Fifty Landrace × Yorkshire sows were divided into four dietary groups throughout gestation: control diet (CON); control diet supplemented with ...
DOI:
10.3390/nu9050423
PubMed:
28445388
PubMed Central:
PMC5452153

44. Maternal exposure to bisphenol A induces fetal growth restriction via upregulating the expression of estrogen receptors.

Author:
Yuming Cao; Zhenlie Chen; Ming Zhang; Lei Shi; Songling Qin; Dan Lv; Danyang Li; Ling Ma; Yuanzhen Zhang
Source:
Chemosphere 2022 v.287 pp. 132244
ISSN:
0045-6535
Subject:
DNA methylation; DNA methyltransferase; apoptosis; bisphenol A; breast neoplasms; estrogens; fetal development; flow cytometry; humans; maternal exposure; placenta
Abstract:
... Bisphenol A (BPA) accumulation in the placenta leads to fetal growth restriction (FGR). Here we aimed to explore the effect and the underlying mechanism of BPA exposure on fetal development. ELISA was performed to measure estrogen levels in human placenta and BeWo cells. qRT-PCR and Western blotting were conducted to determine the expression of estrogen receptors (ERs), breast cancer resistance pr ...
DOI:
10.1016/j.chemosphere.2021.132244

45. Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development

Author:
Dolinoy, Dana C.; Huang, Dale; Jirtle, Randy L.
Source:
Proceedings of the National Academy of Sciences of the United States of America 2007 v.104 no.32 pp. 13056-13061
ISSN:
0027-8424
Subject:
toxic substances; environmental exposure; females; genotoxicity; DNA methylation; loci; retrotransposons; maternal nutrition; dietary supplements; folic acid; genistein; protective effect; progeny; epigenetics; genome; mice; bisphenol A
Abstract:
... The hypothesis of fetal origins of adult disease posits that early developmental exposures involve epigenetic modifications, such as DNA methylation, that influence adult disease susceptibility. In utero or neonatal exposure to bisphenol A (BPA), a high-production-volume chemical used in the manufacture of polycarbonate plastic, is associated with higher body weight, increased breast and prostate ...
DOI:
10.1073/pnas.0703739104
PubMed:
17670942
PubMed Central:
PMC1941790

46. Maternal urinary concentrations of bisphenol A during pregnancy are associated with global DNA methylation in cord blood of newborns in the “NELA” birth cohort

Author:
Fuensanta Navarro-Lafuente; Evdochia Adoamnei; Julián J. Arense-Gonzalo; María T. Prieto-Sánchez; María L. Sánchez-Ferrer; Antonio Parrado; Mariana F. Fernández; Beatriz Suarez; Antonia López-Acosta; Antonio Sánchez-Guillamón; Luis García-Marcos; Eva Morales; Jaime Mendiola; Alberto M. Torres-Cantero; the NELA Study group
Source:
Science of the total environment 2022 v.838 pp. 156540
ISSN:
0048-9697
Subject:
DNA methylation; asthma; bisphenol A; bisphenol F; bisphenol S; blood; environment; epigenome; females; fetal development; high-throughput nucleotide sequencing; humans; liquid-phase microextraction; males; nutrition; pregnancy; public health; regression analysis; risk; tandem mass spectrometry; ultra-performance liquid chromatography
Abstract:
... Endocrine disrupting chemicals (EDCs) set a public health risk through disruption of normal physiological processes. The toxicoepigenetic mechanisms of developmental exposure to common EDCs, such as bisphenol A (BPA), are poorly known. The present study aimed to evaluate associations between perinatal maternal urinary concentrations of BPA, bisphenol S (BPS) and bisphenol F (BPF) and LINE-1 (long ...
DOI:
10.1016/j.scitotenv.2022.156540

47. Metabolic signatures of bisphenol A and genistein in Atlantic salmon liver cells

Author:
Pål A. Olsvik; Kaja H. Skjærven; Liv Søfteland
Source:
Chemosphere 2017 v.189 pp. 730-743
ISSN:
0045-6535
Subject:
DNA; DNA methylation; Salmo salar; aquaculture feeds; biochemical pathways; biosynthesis; bisphenol A; carbohydrate metabolism; cell viability; cytotoxicity; energy; fish; gene expression regulation; genistein; glucose; glutamic acid; hepatocytes; homeostasis; metabolites; metabolomics; methionine; models; pesticides; screening; toxic substances; transcription (genetics); transcriptomics; uridine
Abstract:
... Screening has revealed that aquafeeds with high inclusion of plant material may contain small amounts of endocrine disrupting agricultural pesticides. In this work, bisphenol A (BPA) and genistein (GEN) were selected as model endocrine disrupting toxicants with impact on DNA methylation in fish. Atlantic salmon hepatocytes were exposed in vitro to four concentrations of BPA and GEN (0.1, 1.0, 10 a ...
DOI:
10.1016/j.chemosphere.2017.09.076

48. Multigenerational impacts of gestational bisphenol A exposure on the sperm function and fertility of male mice

Author:
Md Saidur Rahman; Won-Ki Pang; Do-Yeal Ryu; Yoo-Jin Park; Buom-Yong Ryu; Myung-Geol Pang
Source:
Journal of hazardous materials 2021 v.416 pp. 125791
ISSN:
0304-3894
Subject:
DNA methylation; bisphenol A; body weight; corn oil; epigenetics; females; male fertility; males; pregnancy; proteomics; spermatogenesis; spermatozoa; testes
Abstract:
... Growing evidence suggests that developmental exposure to bisphenol A (BPA)—a synthetic endocrine disruptor—causes atypical reproductive phenotypes that may persist for generations. However, the precise mechanism(s) by which BPA causes these adverse consequences is unclear. Here, pregnant female mice were orally exposed to 50 μg, 5 mg, and 50 mg BPA/kg body weight (bw)/day from 7 to 14 days of gest ...
DOI:
10.1016/j.jhazmat.2021.125791

49. Neonatal exposure of bisphenol A led to increased lipolysis of visceral adipose tissue in adult rats with DNA hypomethylation of Atgl being one of the possible underlying mechanisms

Author:
Zhang-Hong Ke; Ai-Li Yu; Xue-Fen Cai; Yan Sun; Hui-Ling Xu; Meng Chen; Chen-Xi Chen; Bei-Hong Zheng
Source:
Toxicology 2022 v.473 pp. 153194
ISSN:
0300-483X
Subject:
DNA hypomethylation; United States Environmental Protection Agency; adipocytes; adipose tissue; animal models; bisphenol A; blood serum; body weight; free fatty acids; glucose; glycerol; lipolysis; males; subcutaneous injection; toxicology; triacylglycerol lipase
Abstract:
... Accumulating evidence suggests the role of developmental exposure of bisphenol A (BPA) in metabolic disorders. However, the underlying mechanism remains unclear. Using a rat model, we investigated the neonatal exposure of BPA on lipid metabolism in adult and the underlying mechanisms. From postnatal day1(PND1) to PND10, male rats were exposed to BPA via daily subcutaneous injection with 10 µg/100  ...
DOI:
10.1016/j.tox.2022.153194

50. Obesogen effect of bisphenol S alters mRNA expression and DNA methylation profiling in male mouse liver

Author:
Ludovic le Corre; Axelle Brulport; Daniel Vaiman; Marie-Christine Chagnon; Ludovic Le Corre
Source:
Chemosphere 2020 v.241 pp. 125092
ISSN:
0045-6535
Subject:
DNA hypomethylation; autosomes; bisphenol A; bisphenol S; body fat; endocrine-disrupting chemicals; epigenetics; gene expression; gene expression regulation; gene ontology; genes; homeostasis; lipid metabolism; liver; liver cirrhosis; males; manufacturing; messenger RNA; mice; obesity; plastics; pollution; resins; sex chromosomes; translation (genetics); triacylglycerols
Abstract:
... Environmental pollution is increasingly considered an important factor involved in the obesity incidence. Endocrine disruptors (EDs) are important actors in the concept of DOHaD (Developmental Origins of Health and Disease), where epigenetic mechanisms play crucial roles. Bisphenol A (BPA), a monomer used in the manufacture of plastics and resins is one of the most studied obesogenic endocrine dis ...
DOI:
10.1016/j.chemosphere.2019.125092

51. Oxidative Stress and DNA methylation in male rat pups provoked by the transplacental and translactational exposure to bisphenol A

Author:
Hanan M. A. El Henafy; Marwa A. Ibrahim; Samy A. Abd El Aziz; Eman M. Gouda
Source:
Environmental science and pollution research international 2020 v.27 no.4 pp. 4513-4519
ISSN:
0944-1344
Subject:
DNA; DNA methylation; albino; biomarkers; bisphenol A; blood serum; body weight; epididymis; epigenetics; estrogen receptors; females; genes; glutathione peroxidase; glutathione transferase; inheritance (genetics); lactation; males; malondialdehyde; oxidative stress; pollution; polymerase chain reaction; pregnancy; progeny; promoter regions; pups; rats; superoxide dismutase; testes; testosterone; weaning
Abstract:
... The epigenetic changes induced by environmental contaminants play important roles in the inheritance of male reproductive dysfunction. The present study investigated DNA methylation changes and some oxidative stress biomarkers induced by bisphenol A (BPA) in male offspring. A total number of 48 female albino rats were administered orally with 50 μg/kg of BPA/day during gestation and/or lactation p ...
DOI:
10.1007/s11356-019-06553-5

52. Perinatal exposure to bisphenol A modifies the transcriptional regulation of the β-Casein gene during secretory activation of the rat mammary gland

Author:
Gabriela A. Altamirano; Jorge G. Ramos; Ayelen L. Gomez; Enrique H. Luque; Monica Muñoz-de-Toro; Laura Kass
Source:
Molecular and cellular endocrinology 2017 v.439 pp. 407-418
ISSN:
0303-7207
Subject:
DNA methylation; beta-casein; bisphenol A; enzymes; epigenetics; exons; extracellular matrix; females; glucocorticoid receptors; histones; integrins; lactation; mammary glands; pregnancy; prolactin; prolactin receptors; rats; signal transduction; transcription (genetics); weaning
Abstract:
... With the aim to analyze whether bisphenol A (BPA) modifies β-Casein (β-Cas) synthesis and transcriptional regulation in perinatally exposed animals, here, pregnant F0 rats were orally exposed to 0, 0.6 or 52 μg BPA/kg/day from gestation day 9 until weaning. Then, F1 females were bred and mammary glands were obtained on lactation day 2. Perinatal BPA exposure decreased β-Cas expression without modi ...
DOI:
10.1016/j.mce.2016.09.032

53. Potential roles of noncoding RNAs in environmental epigenetic transgenerational inheritance

Author:
Wei Yan
Source:
Molecular and Cellular Endocrinology 2014 v.398 pp. 24-30
ISSN:
0303-7207
Subject:
DDT (pesticide); DNA methylation; bisphenol A; dioxins; eggs; environmental factors; epigenetics; genes; genetic engineering; histones; hydrocarbons; mammals; messenger RNA; methoxychlor; non-coding RNA; phenotype; phthalates; spermatozoa; toxic substances; transcription (genetics); transcriptome; vinclozolin
Abstract:
... “Epigenetic transgenerational inheritance” (ETI) has been defined as germline (sperm or egg) transmission of epigenetic information between generations in the absence of direct exposures or genetic manipulations. Among reported cases of ETI in mammals, the majority are induced by environmental factors, including environmental toxicants [e.g. agricultural fungicide vinclozolin, plastic additive bis ...
DOI:
10.1016/j.mce.2014.09.008
PubMed:
25224488
PubMed Central:
PMC4262681

54. Prenatal Bisphenol a Exposure and Postnatal Trans Fat Diet Alter Small Intestinal Morphology and Its Global DNA Methylation in Male Sprague-Dawley Rats, Leading to Obesity Development

Author:
Sarah Zulkifli; Noor Shafina Mohd Nor; Siti Hamimah Sheikh Abdul Kadir; Norashikin Mohd Ranai; Noor Kaslina Mohd Kornain; Wan Nor I’zzah Wan Mohd Zain; Mardiana Abdul Aziz
Source:
Nutrients 2022 v.14 no.12 pp. -
ISSN:
2072-6643
Subject:
DNA methylation; adulthood; bisphenol A; food intake; histology; ileum; males; obesity; pregnancy; progeny; trans fatty acids; waist circumference
Abstract:
... In this study, we aimed to determine whether a postnatal trans fat diet (TFD) could aggravate prenatal bisphenol A (BPA) exposure effects on offspring’s small intestine and adulthood obesity, due to the relatively sparse findings on how the interaction between these two variables interrupt the small intestinal cells. Twelve pregnant rats were administered with either unspiked drinking water (contr ...
DOI:
10.3390/nu14122382

55. Prenatal Exposure to Bisphenol A Analogues on Male Reproductive Functions in Mice

Author:
Mingxin Shi; Nikola Sekulovski; James A MacLean; Kanako Hayashi
Source:
Toxicological sciences 2018 v.163 no.2 pp. 620-631
ISSN:
1096-0929
Subject:
DNA methylation; adults; apoptosis; autophagy; bisphenol A; blood serum; corn oil; histone code; males; maternal exposure; methyltransferases; models; morphometry; sperm motility; spermatogenesis; spermatozoa; testes; toxicology
Abstract:
... This study was performed to examine whether prenatal exposure to bisphenol (BP) A analogues, BPE and BPS, negatively impacts male reproductive functions and testis development using mice as a model. CD-1 mice were orally exposed to control treatment (corn oil), BPA, BPE, and BPS (0.5, 20, or 50 µg/kg/day) from gestational day 11 (the presence of vaginal plug = 1) to birth. Although sperm counts we ...
DOI:
10.1093/toxsci/kfy061

56. Prenatal exposure to phthalates and peripheral blood and buccal epithelial DNA methylation in infants: An epigenome-wide association study

Author:
Gillian England-Mason; Sarah M. Merrill; Nicole Gladish; Sarah R. Moore; Gerald F. Giesbrecht; Nicole Letourneau; Julia L. MacIsaac; Amy M. MacDonald; David W. Kinniburgh; Anne-Louise Ponsonby; Richard Saffery; Jonathan W. Martin; Michael S. Kobor; Deborah Dewey; the APrON Study Team
Source:
Environment international 2022 v.163 pp. 107183
ISSN:
0160-4120
Subject:
DNA damage; DNA methylation; biomarkers; bisphenol A; blood; environment; epithelium; genes; maternal exposure; metabolites; molecular weight; neurodevelopment; nutrition; phthalates; placenta; umbilical cord; urine; Alberta
Abstract:
... Prenatal exposure to phthalates has been associated with adverse health and neurodevelopmental outcomes. DNA methylation (DNAm) alterations may be a mechanism underlying these effects, but prior investigations of prenatal exposure to phthalates and neonatal DNAm profiles are limited to placental tissue and umbilical cord blood. Conduct an epigenome-wide association study (EWAS) of the associations ...
DOI:
10.1016/j.envint.2022.107183

57. Sex-specific epigenetic disruption and behavioral changes following low-dose in utero bisphenol A exposure

Author:
Marija Kundakovic; Kathryn Gudsnuk; Becca Franks; Jesus Madrid; Rachel L. Miller; Frederica P. Perera; Frances A. Champagne
Source:
Proceedings of the National Academy of Sciences of the United States of America 2013 v.110 no.24 pp. 9956-9961
ISSN:
0027-8424
Subject:
DNA; DNA methylation; behavior change; bisphenol A; cortex; dose response; endocrine-disrupting chemicals; epigenetics; estrogen receptors; females; gene expression; genes; hypothalamus; juveniles; males; messenger RNA; methyltransferases; mice; mothers; phenotype; plastics; pregnancy; progeny
Abstract:
... Bisphenol A (BPA) is an estrogenic endocrine disruptor widely used in the production of plastics. Increasing evidence indicates that in utero BPA exposure affects sexual differentiation and behavior; however, the mechanisms underlying these effects are unknown. We hypothesized that BPA may disrupt epigenetic programming of gene expression in the brain. Here, we provide evidence that maternal expos ...
DOI:
10.1073/pnas.1214056110
PubMed:
23716699
PubMed Central:
PMC3683772

58. The DNA methylation status alteration of two steroidogenic genes in gonads of rare minnow after bisphenol A exposure

Author:
Ting Zhang; Yan Liu; Hong Chen; Jiancao Gao; Yingying Zhang; Cong Yuan; Zaizhao Wang
Source:
Comparative biochemistry and physiology 2017 v.198 pp. 9-18
ISSN:
1532-0456
Subject:
DNA methylation; Gobiocypris rarus; biosynthesis; bisphenol A; blood serum; estradiol; gene expression; genes; loci; messenger RNA; minnows; testes; transcription (genetics)
Abstract:
... Both cytochrome P450c17 (CYP17A1) and P-450 side chain cleavage (CYP11A1) play important roles in steroid biosynthesis. According to our previous studies, bisphenol A (BPA) could regulate the mRNA expression of cyp17a1 and cyp11a1 in rare minnow Gobiocypris rarus. However, the potential mechanism of the regulation is barely understood. In the present study, aiming to explore how BPA affects the mR ...
DOI:
10.1016/j.cbpc.2017.05.001

59. Transgenerational effects of BPA on female reproduction

Author:
Stefania Santangeli; Claudia Consales; Francesca Pacchierotti; Hamid Habibi; Oliana Carnevali
Source:
Science of the total environment 2019 pp. -
ISSN:
0048-9697
Subject:
DNA methylation; Danio rerio; adults; bisphenol A; embryo (animal); epigenetics; female fertility; females; gene expression; genes; germ cells; gonads; males; meiosis; messenger RNA; mitosis; urine; Canada; United States
Abstract:
... Bisphenol A (BPA) is consistently present in the environment and studies have shown BPA presence in the urine of over 90% of population tested in Canada and USA. In addition to its reported harmful effects, there is concern for its transgenerational effects. For a compound to induce a transgenerational effect, an epigenetic mark should be mitotically and meiotically stable and should not be reprog ...
DOI:
10.1016/j.scitotenv.2019.06.029

60. Transgenerational inheritance of heart disorders caused by paternal bisphenol A exposure

Author:
Marta Lombó; Cristina Fernández-Díez; Silvia González-Rojo; Claudia Navarro; Vanesa Robles; María Paz Herráez
Source:
Environmental pollution 2015 v.206 pp. 667-678
ISSN:
0269-7491
Subject:
Danio rerio; adults; bisphenol A; early development; endocrine-disrupting chemicals; females; gene expression regulation; genes; heart; heart failure; heart rate; human fertility; inheritance (genetics); insulin; insulin receptors; males; manufacturing; messenger RNA; obesity; paternal effect; plastics; progeny; signal transduction; spermatogenesis; spermatozoa; transcriptome
Abstract:
... Bisphenol A (BPA) is an endocrine disruptor used in manufacturing of plastic devices, resulting in an ubiquitous presence in the environment linked to human infertility, obesity or cardiovascular diseases. Both transcriptome and epigenome modifications lie behind these disorders that might be inherited transgenerationally when affecting germline. To assess potential effects of paternal exposure on ...
DOI:
10.1016/j.envpol.2015.08.016