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- Tsuji, Shogo, et al. Show all 3 Authors
- Chemical communications 2016 v.52 no.99 pp. 14238-14241
- DNA methylation; amino acids; chemical compounds; genes; genomics; screening; transactivators
- ... A 5mC-selective TALE-repeat was created by screening a TALE repeat library containing randomized amino acids at repeat variable diresidues and their neighboring residues. The new repeat showed high 5mC discrimination ability. An artificial TALE containing the new repeat activated an endogenous gene in a genomic methylation status-dependent manner. ...