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1. Aeromonas salmonicida aptamer selection and construction for colorimetric and ratiometric fluorescence dual-model aptasensor combined with g-C3N4 and G-quadruplex

Author:
Qiujun Lu; Shengnan Zhang; Yuzhen Ouyang; Chun Zhang; Meiling Liu; Youyu Zhang; Le Deng
Source:
Talanta 2023 v.252 pp. 123857
ISSN:
0039-9140
Subject:
Aeromonas salmonicida; Danio rerio; aptasensors; aquaculture; color; colorimetry; detection limit; early diagnosis; fluorescence; food safety; oligonucleotides; opportunistic pathogens; rapid methods; single-stranded DNA; systematic evolution of ligands by exponential enrichment
Abstract:
... Aeromonas salmonicida (A. salmonicida) is an important opportunistic pathogen to aquatic animals that causes severe economic losses to aquaculture, which makes its rapid detection and prevention are critical. In this work, a single-stranded DNA (ssDNA) aptamer (A.s-2) with high specificity to the bacteria was selected by Systematic Evolution of Ligands by Exponential Enrichment (SELEX). The select ...
DOI:
10.1016/j.talanta.2022.123857

2. Anti-inflammatory and immunostimulant effect of different timing-related administration of dietary polyphenols on intestinal inflammation in zebrafish, Danio rerio

Author:
Roberta Imperatore; Graziella Orso; Serena Facchiano; Pierpaolo Scarano; Seyed Hossein Hoseinifar; Ghasem Ashouri; Carmine Guarino; Marina Paolucci
Source:
Aquaculture 2023 v.563 pp. 738878
ISSN:
0044-8486
Subject:
Castanea sativa; Danio rerio; Verbascum; adults; antioxidant activity; antioxidants; aquaculture; assets; catalase; diet; feed additives; flavonoids; gene expression; immunostimulants; inflammation; interleukin-10; intestines; mitogen-activated protein kinase; models; phosphorylation; polyphenols; prostaglandin synthase; superoxide dismutase; transcription factor NF-kappa B; tumor necrosis factors
Abstract:
... A short-term study was performed to assess the effects of diets supplemented with polyphenols (CSVP), extracted from the chestnut (Castanea sativa) shell, agri-food waste rich in tannins, and mullein (Verbascum macrurum), a perennial spontaneous plant rich in flavonoids, on a zebrafish (Danio rerio) model of k-carrageenan-induced intestinal inflammation. Morphological asset of intestine, immunoden ...
DOI:
10.1016/j.aquaculture.2022.738878

3. Developmental toxicity of TCBPA on the nervous and cardiovascular systems of zebrafish (Danio rerio): A combination of transcriptomic and metabolomics

Author:
Wentao Liu; Yifan Pan; Lu Yang; Yun Xie; Xuanyue Chen; Jing Chang; Weiyu Hao; Lifei Zhu; Bin Wan
Source:
Journal of environmental sciences (China) 2023 v.127 pp. 197-209
ISSN:
1001-0742
Subject:
Danio rerio; blood; developmental toxicity; flame retardants; focal adhesions; humans; metabolomics; transcriptomics; China
Abstract:
... Tetrachlorobisphenol A (TCBPA), a widely used halogenated flame retardant, is frequently detected in environmental compartments and human samples. However, unknown developmental toxicity and mechanisms limit the entire understanding of its effects. In this study, zebrafish (Danio rerio) embryos were exposed to various concentrations of TCBPA while a combination of transcriptomics, behavioral and b ...
DOI:
10.1016/j.jes.2022.04.022

4. Exposure of zebrafish (Danio rerio) to trans-2-hexenal induces oxidative stress and protein degeneration of the gill

Author:
Dicheng Ma; Haiyan Yu; Guangrui Cui; Jiamei Zhu; Bingyu Zhu; Wei Mu; Feng Liu
Source:
Science of the total environment 2023 v.854 pp. 158813
ISSN:
0048-9697
Subject:
Danio rerio; biopesticides; cell death; chronic toxicity; denaturation; environment; intravenous injection; malondialdehyde; methionine; mortality; oral administration; oxidative stress; protein denaturation; risk; risk assessment; succinate dehydrogenase (quinone)
Abstract:
... Trans-2-hexenal (T2H) has great commercial value for development as a biopesticide, but its toxicity risk to nontarget organisms is unknown. Here, the toxicity and underlying mechanism of T2H on zebrafish (Danio rerio) were investigated. The LC₅₀ (48 h) of T2H on zebrafish is 4.316 μg/mL, and the aldehyde group is essential to its toxicity. In 14-day chronic toxicity tests, 0.432 μg/mL T2H resulte ...
DOI:
10.1016/j.scitotenv.2022.158813

5. Global warming and glyphosate toxicity (II): Offspring zebrafish modelling with behavioral, morphological and immunohistochemical approaches

Author:
Ekrem Sulukan; Alper Baran; Meryem Kankaynar; Tuğba Kızıltan; İsmail Bolat; Serkan Yıldırım; Hacer Akgül Ceyhun; Saltuk Buğrahan Ceyhun
Source:
Science of the total environment 2023 v.856 pp. 158903
ISSN:
0048-9697
Subject:
Danio rerio; adults; apoptosis; aquatic ecosystems; blood flow; environment; fish; glyphosate; heart rate; immunohistochemistry; lipids; locomotion; models; mouth; progeny; reactive oxygen species; serotonin; survival rate; temperature; thigmotaxis; toxicity
Abstract:
... The increase in temperature due to global warming greatly affects the toxicity produced by pesticides in the aquatic ecosystem. Studies investigating the effects of such environmental stress factors on next generations are important in terms of the sustainability of ecosystems. In this study, the effects of parental synergistic exposure to glyphosate and temperature increase on the next generation ...
DOI:
10.1016/j.scitotenv.2022.158903

6. Mepanipyrim induces cardiotoxicity of zebrafish (Danio rerio) larvae via promoting AhR-regulated COX expression pathway

Author:
Chao Shen; Jing He; Kongyang Zhu; Naying Zheng; Yue Yu; Chengyong He; Chunyan Yang; Zhenghong Zuo
Source:
Journal of environmental sciences (China) 2023 v.125 pp. 650-661
ISSN:
1001-0742
Subject:
Danio rerio; agonists; antagonists; bioassays; calcium; cardiomyocytes; cardiotoxicity; electron transport chain; gene expression; heart rate; human health; mepanipyrim; mitochondria; toxicity; viticulture; China
Abstract:
... The wide use of pesticides has seriously threatened human health and the survival of beneficial organisms. The fungicide mepanipyrim is widely used in viticulture practices. Studies of mepanipyrim-induced toxicity in organisms are still scarce, especially studies on cardiotoxicity. In this study, we aimed to investigate mepanipyrim-induced cardiotoxicity in zebrafish (Danio rerio) larvae. We found ...
DOI:
10.1016/j.jes.2022.01.012

7. Mepanipyrim induces visual developmental toxicity and vision-guided behavioral alteration in zebrafish larvae

Author:
Chao Shen; Yimei Cai; Jialing Li; Chengyong He; Zhenghong Zuo
Source:
Journal of environmental sciences (China) 2023 v.124 pp. 76-88
ISSN:
1001-0742
Subject:
Danio rerio; anilinopyrimidine fungicides; aryl hydrocarbon receptors; developmental toxicity; fruit growing; fungi; genes; light intensity; mepanipyrim; opsin; phototransduction; quantitative polymerase chain reaction; transcriptomics; wavelengths; China
Abstract:
... Mepanipyrim, an anilinopyrimidine fungicide, has been extensively used to prevent fungal diseases in fruit culture. Currently, research on mepanipyrim-induced toxicity in organisms is still very scarce, especially visual developmental toxicity. Here, zebrafish larvae were employed to investigate mepanipyrim-induced visual developmental toxicity. Intense light and monochromatic light stimuli-evoked ...
DOI:
10.1016/j.jes.2021.11.008

8. Nuclease treatment enhances the probiotic effect of Bacillus velezensis T23 on hepatic steatosis and inflammation induced by high-fat diet in zebrafish

Author:
Fengli Zhang; Yinyin Luan; Qiang Hao; Qingshuang Zhang; Yalin Yang; Chao Ran; Zhen Zhang; Zhigang Zhou
Source:
Aquaculture 2023 v.562 pp. 738801
ISSN:
0044-8486
Subject:
Bacillus velezensis; Danio rerio; antioxidant activity; aquaculture; complement; fatty liver; fermented foods; high fat diet; immunity; inflammation; interleukin-6; intestinal microorganisms; intestines; lipogenesis; liver; lysozyme; mucus; nucleotides; probiotics; weight gain
Abstract:
... Metabolic diseases caused by high-fat diet (HFD) have been a major problem currently in aquaculture. Nucleotides have been used as functional nutrients to improve the growth and health of fish，such as stimulating immune responses, such as immune cells and complement lytic activity. In this experiment, we supplemented solid fermentation product of Bacillus velezensis T23 and nuclease-treated Bacill ...
DOI:
10.1016/j.aquaculture.2022.738801

9. Nucleus-targeting pH-Responsive carbon dots for fast nucleus pH detection

Author:
Samran Durrani; Zihuayuan Yang; Jie Zhang; Zihao Wang; Haiyan Wang; Faran Durrani; Fu-Gen Wu; Fengming Lin
Source:
Talanta 2023 v.252 pp. 123855
ISSN:
0039-9140
Subject:
Alzheimer disease; Danio rerio; RNA; carbon; cell nucleolus; endocytosis; fluorescence; heart diseases; light intensity; lipids; pH; photoluminescence
Abstract:
... Nucleus pH is closely linked to many diseases such as aging, heart disease, skeletal myopathies, cancer, Alzheimer's disease, etc. Nevertheless, fluorescent sensors that can directly monitor nucleus pH changes have not yet been reported. Here, we first reported a green emissive carbon dots (CDs) for nucleus pH detection in living cells. CDs can selectively target nucleus with high accumulation at ...
DOI:
10.1016/j.talanta.2022.123855

10. Parental and transgenerational impairments of thyroid endocrine system in zebrafish by 2,4,6-tribromophenol

Author:
Yuxi Zhou; Juanjuan Fu; Min Wang; Yongyong Guo; Lihua Yang; Jian Han; Bingsheng Zhou
Source:
Journal of environmental sciences (China) 2023 v.124 pp. 291-299
ISSN:
1001-0742
Subject:
Danio rerio; adults; bioaccumulation; brain; chemical analysis; flame retardants; histopathology; humans; liver; pollution; progeny; toxicity; transcription (genetics); China
Abstract:
... Many environmental contaminants could be transmitted from parents and generate impairments to their progeny. The 2,4,6-tribromophenol (TBP), a novel brominated flame retardant which has been frequently detected in various organisms, was supposed to be bioaccumulated and intergenerational transmitted in human beings. Previous studies revealed that TBP could disrupt thyroid endocrine system in zebra ...
DOI:
10.1016/j.jes.2021.09.022

11. Pathogenic infection and microbial composition of yellow catfish (Pelteobagrus fulvidraco) challenged by Aeromonas veronii and Proteus mirabilis

Author:
Wanying Zhai; Qian Wang; Xinpeng Zhu; Xiaoying Jia; Liangbiao Chen
Source:
Aquaculture and fisheries 2023 v.8 no.2 pp. 166-173
ISSN:
2468-550X
Subject:
Aeromonas veronii; Danio rerio; Ictalurus punctatus; Moraxella; Proteus mirabilis; Tachysurus fulvidraco; Vibrio; bacterial communities; catfish; disease prevention; freshwater fish; intraperitoneal injection; microbiome; mortality; mucus; pathogenicity; China
Abstract:
... The catfishes are a group of economically important freshwater fish in China, which in recent years have suffered heavy losses as a result of bacterial outbreaks. In this study, we examined the diversity of the microbiome of infected skin mucus of yellow catfish (Pelteobagrus fulvidraco) and channel catfish (Ictalurus punctatus) and analyzed the bacterial pathogens. We found several common pathoge ...
DOI:
10.1016/j.aaf.2021.05.007

12. Silica crystals activate toll-like receptors and inflammasomes to promote local and systemic immune responses in zebrafish

Author:
Sylwia D. Tyrkalska; Annamaria Pedoto; Alicia Martínez-López; José A. Ros-Lucas; Pablo Mesa-del-Castillo; Sergio Candel; Victoriano Mulero
Source:
Developmental and comparative immunology 2023 v.138 pp. 104523
ISSN:
0145-305X
Subject:
Danio rerio; brain; immune system; immunology; inflammasomes; inflammation; models; pyroptosis; respiratory tract diseases; silica
Abstract:
... Silica crystals are potent activators of the inflammasome that cause a fibrotic lung disease, called silicosis, with no effective treatment available. We report here that injection of silica crystals into the hindbrain ventricle of zebrafish embryos led to the initiation of local and systemic immune responses driven through both Toll-like receptors (TLR)- and inflammasome-dependent signaling pathw ...
DOI:
10.1016/j.dci.2022.104523

13. TLR5M cooperates with TLR5S to activate NF-κB in Nile tilapia (Oreochromis niloticus)

Author:
Zijiong Dong; Jiadong Li; Ruhuang Deng; Zhenzhen Zhang; Jianlin Chen; Yang Lei; Liting Wu; Zheng Guo; Bei Wang; Bingxi Li; Fang Liang; Jianmin Ye
Source:
Aquaculture 2023 v.562 pp. 738775
ISSN:
0044-8486
Subject:
Aeromonas hydrophila; Danio rerio; Oreochromis niloticus; Toll-like receptor 5; aquaculture; brain; cell membranes; cytokines; disease prevention; fish; flagellin; kidneys; liver; macrophages; monocytes; pathogens; spleen
Abstract:
... The binding of flagellin to receptor TLR5 (Toll-like receptor 5) on the cell surface is a prerequisite for the pathogen infection to the body, which has important implication for disease prevention. Unlike mammals, teleost TLR5 exists in two different forms: membrane-bound TLR5M (membrane TLR5, TLR5M) and secreted TLR5S (soluble TLR5, TLR5S). In this study, TLR5M and TLR5S from Nile tilapia (Oreoc ...
DOI:
10.1016/j.aquaculture.2022.738775

14. Tocopherol-assisted magnetic Ag-Fe3O4-TiO2 nanocomposite for photocatalytic bacterial-inactivation with elucidation of mechanism and its hazardous level assessment with zebrafish model

Author:
Rajaiah Alexpandi; Gurusamy Abirami; Balaji Murugesan; Ravindran Durgadevi; Roshni Prithiviraj Swasthikka; Yurong Cai; Thennarasu Ragupathi; Arumugam Veera Ravi
Source:
Journal of hazardous materials 2023 v.442 pp. 130044
ISSN:
0304-3894
Subject:
Danio rerio; bacterial contamination; biochemical pathways; cell membranes; death; magnetism; models; nanocomposites; nanomaterials; oxidative stress; photocatalysis; photocatalysts; proteomics; seawater; solar radiation; toxicity; water treatment
Abstract:
... In recent years, many endeavours have been prompted with photocatalytic nanomaterials by the need to eradicate pathogenic microorganisms from water bodies. Herein, a tocopherol-assisted Ag-Fe₃O₄-TiO₂ nanocomposite (TAFTN) was synthesized for photocatalytic bacterial inactivation. The prepared TAFTN became active under sunlight due to its narrowed bandgap, inactivating the bacterial contaminants vi ...
DOI:
10.1016/j.jhazmat.2022.130044

15. Transcriptome reveals overview of Ca2+ dose-dependent metabolism disorders in zebrafish larvae after Cd2+ exposure

Author:
Biran Zhu; Ziniu Wang; Lei Lei; Yongyong Guo; Jian Han; Bingsheng Zhou
Source:
Journal of environmental sciences (China) 2023 v.125 pp. 480-491
ISSN:
1001-0742
Subject:
Danio rerio; cadmium; calcium; dose response; gene expression regulation; heavy metals; lipid metabolism; remission; toxicity; toxicology; transcriptome; water hardness; China
Abstract:
... Cadmium (Cd), a ubiquitous environmental hazardous heavy metal, poses a significant threat to the health of aquatic organisms, including teleosts. Although the toxic profile of Cd is well recognized, little is known regarding the overall view of toxic responses to varying aquatic environmental parameters (e.g., water hardness) at an individual level. Herein, differences in water hardness were part ...
DOI:
10.1016/j.jes.2021.12.009

16. Variability in fecal metabolome depending on age, PFBS pollutant, and fecal transplantation in zebrafish: A non-invasive diagnosis of health

Author:
Baili Sun; Mengyuan Liu; Lizhu Tang; Xiangzhen Zhou; Chenyan Hu; Lianguo Chen
Source:
Journal of environmental sciences (China) 2023 v.127 pp. 530-540
ISSN:
1001-0742
Subject:
Danio rerio; absorption; adults; amino acids; carbohydrates; digestion; early diagnosis; feces; intestinal microorganisms; lipids; metabolites; metabolome; metabolomics; neurotransmitters; pollutants; prediction; steroid hormones; synaptic transmission; therapeutics; toxicity; toxicology; China
Abstract:
... To protect the wellbeing of research animals, certain non-invasive measures are in increasing need to facilitate an early diagnosis of health and toxicity. In this study, feces specimen was collected from adult zebrafish to profile the metabolome fingerprint. Variability in fecal metabolite composition was also distinguished as a result of aging, perfluorobutanesulfonate (PFBS) toxicant, and fecal ...
DOI:
10.1016/j.jes.2022.06.019

17. A new ratiometric AIE fluorescent probe for detecting cysteine in food samples and imaging in the biological system

Author:
Shuai Gong; Ahui Qin; Yan Zhang; Mingxin Li; Xiaoyi Chen; Yueyin Liang; Xu Xu; Zhonglong Wang; Shifa Wang
Source:
Food chemistry 2023 v.400 pp. 134108
ISSN:
0308-8146
Subject:
Danio rerio; apples; bamboos; cabbage; cysteine; detection limit; dried milk; fluorescence; fluorescent dyes; food chemistry; food industry; garlic; liquids; milk; pears; wavelengths
Abstract:
... l-Cysteine (Cys) plays a vital part in the food industry and biological processes. Herein, a novel ratiometric fluorescent probe NFA with aggregation-induced emission (AIE) property was developed to discriminate Cys from Hcy and GSH. The probe showed a ratiometric fluorescence response to Cys with the emission wavelength shifted from 450 nm to 495 nm. Probe NFA possessed good advantages in the det ...
DOI:
10.1016/j.foodchem.2022.134108

18. 1,6-epi-Cyclophellitol Cyclosulfamidate Is a Bona Fide Lysosomal α-Glucosidase Stabilizer for the Treatment of Pompe Disease

Author:
Ken Kok; Chi-Lin Kuo; Rebecca E. Katzy; Lindsey T. Lelieveld; Liang Wu; Véronique Roig-Zamboni; Gijsbert A. van der Marel; Jeroen D. C. Codée; Gerlind Sulzenbacher; Gideon J. Davies; Herman S. Overkleeft; Johannes M. F. G. Aerts; Marta Artola
Source:
Journal of the American Chemical Society 2022 v.144 no.32 pp. 14819-14827
ISSN:
1520-5126
Subject:
Danio rerio; ceramide glucosyltransferase; diabetes; enzyme inhibitors; humans; intestines; lysosomes; stabilizers; therapeutics
Abstract:
... α-Glucosidase inhibitors are potential therapeutics for the treatment of diabetes, viral infections, and Pompe disease. Herein, we report a 1,6-epi-cyclophellitol cyclosulfamidate as a new class of reversible α-glucosidase inhibitors that displays enzyme inhibitory activity by virtue of its conformational mimicry of the substrate when bound in the Michaelis complex. The α-d-glc-configured cyclophe ...
DOI:
10.1021/jacs.2c05666

19. 5-HMF affects cardiovascular development in zebrafish larvae via reactive oxygen species and Wnt signaling pathways

Author:
Yu Jiang; Nan Geng; Mingyong Wang; Wen Wu; Ninghan Feng; Xian Zhang
Source:
Comparative biochemistry and physiology 2022 v.262 pp. 109452
ISSN:
1532-0456
Subject:
Danio rerio; Maillard reaction; acetylcysteine; angiogenesis; apoptosis; cytotoxicity; edema; fluorescence; gene expression; genes; genetically modified organisms; genotoxicity; heart rate; histology; hydroxymethylfurfural; neoplasms; pericardium; phenotype; quantitative analysis; reactive oxygen species; toxicity testing
Abstract:
... 5-Hydroxymethylfurfural (5-HMF) is a small molecule aldehyde compound produced by the Maillard reaction. As 5-HMF exists in a variety of foods and drugs and is easily ingested by humans, it has attracted extensive toxicological attention in recent years. Relevant research showed that 5-HMF has cytotoxicity, genotoxicity, and tumor effects. However, the cardiovascular effects of 5-HMF are unknown. ...
DOI:
10.1016/j.cbpc.2022.109452

20. 5-Hydroxymethyl-2-furaldehyde induces developmental toxicology and decreases bone mineralization in zebrafish larvae

Author:
Yu Jiang; Zhaomin Zhong; Mingyong Wang; Xian Zhang
Source:
Comparative biochemistry and physiology 2022 v.254 pp. 109254
ISSN:
1532-0456
Subject:
Danio rerio; acetylcysteine; bone mineralization; cartilage; developmental toxicity; enzyme activity; gene expression; hydroxymethylfurfural; mortality; reactive oxygen species; skeletal development; toxicology
Abstract:
... In this study, we aimed to assess the developmental toxicity and effects of 5-HMF in zebrafish as a model organism for toxicology studies. To this end, we treated zebrafish embryos with 1–100 μg/ml 5-HMF and observed bone staining, gene expression, and reactive oxygen species levels in order to investigate the toxicological effects of 5-HMF. The results showed that high concentrations of 5-HMF cau ...
DOI:
10.1016/j.cbpc.2021.109254

21. DE- 71 affected the cholinergic system and locomotor activity via disrupting calcium homeostasis in zebrafish larvae

Author:
Xianfeng Wang; Lifeng Zhao; Qipeng Shi; Yongyong Guo; Jianghuan Hua; Jian Han; Lihua Yang
Source:
Aquatic toxicology 2022 v.250 pp. 106237
ISSN:
0166-445X
Subject:
Danio rerio; acetylcholine; agonists; biphenyl; calcium; calcium channels; homeostasis; inducible nitric oxide synthase; locomotion; motor neurons; neurotoxicity; synaptic transmission; toxicology
Abstract:
... Polybrominated diphenyl ethers (PBDEs) can induce neurotoxicity, but the mechanism of their toxicity on the cholinergic system and locomotion behavior remains unclear. In this paper, zebrafish embryos were exposed to DE-71 (0, 1, 3, 10, 30, and 100 µg/L) until 120 h post fertilization, and its effects on the behavior and cholinergic system of zebrafish larvae and its possible mechanism were invest ...
DOI:
10.1016/j.aquatox.2022.106237

22. A53T mutant α-synuclein fibrils formed in macrophage are spread to neurons

Author:
Shogo Moriya; Michiko Hanazono; Takeshi Fukuhara; Katsuro Iwase; Nobutaka Hattori; Masaki Takiguchi
Source:
Cellular and molecular life sciences 2022 v.79 no.5 pp. 234
ISSN:
1420-682X
Subject:
Danio rerio; Lewy bodies; extracellular space; gene ontology; histology; humans; macrophages; mutants; neuroglia; pathogenesis; sequence analysis; transcriptomics; ubiquitin-protein ligase
Abstract:
... Lewy body (LB), which mainly consists of abnormal α-synuclein (αS) aggregates, is a histological hallmark of Parkinson’s disease (PD). αS aggregation and LB inclusions are induced by spreading αS fibrils to neurons; therefore, the formation and transmission of αS fibrils to neurons may play an essential role in initiating LB formation in neurons. αS expressed in neurons is released into the extrac ...
DOI:
10.1007/s00018-022-04263-9

23. Aberrant hepatic lipid metabolism associated with gut microbiota dysbiosis triggers hepatotoxicity of novel PFOS alternatives in adult zebrafish

Author:
Qiyu Wang; Jing Huang; Shuai Liu; Caiyun Wang; Yuanxiang Jin; Hong Lai; Wenqing Tu
Source:
Environment international 2022 v.166 pp. 107351
ISSN:
0160-4120
Subject:
Brevundimonas; Danio rerio; Hyphomicrobium; Legionella; Plesiomonas; Ralstonia; adults; computer simulation; dysbiosis; environment; environmental exposure; hepatotoxicity; histopathology; intestinal microorganisms; lipid metabolism; lipids; liver; liver function; multiomics; perfluorooctane sulfonic acid; sodium; sulfonates; transcription (genetics); wildlife
Abstract:
... Perfluorooctane sulfonate (PFOS) has been reported to induce hepatotoxicity in wildlife and humans. Novel PFOS alternatives have been widely used following restrictions on PFOS, but little is known about their potential toxicity. Here, the first comprehensive investigation on the chronic hepatotoxicity and underlying molecular mechanisms of PFOS, 6:2Cl-PFESA (F-53B), and sodium p-perfluorous nonen ...
DOI:
10.1016/j.envint.2022.107351

24. Absence of mitochondrial responses in muscles of zebrafish exposed to several heat waves

Author:
Elisa Thoral; Damien Roussel; Laura Quispe; Yann Voituron; Loïc Teulier
Source:
Comparative biochemistry and physiology 2022 v.274 pp. 111299
ISSN:
1095-6433
Subject:
Danio rerio; acclimation; ambient temperature; energy; fish; heat; metabolism; mitochondria; muscles; phosphorylation
Abstract:
... Heat waves are extreme thermal events whose frequency and intensity will increase with global warming. As metabolic responses to temperature are time-dependent, we explored the effects of an exposure to several heat waves on the mitochondrial metabolism of zebrafish Danio rerio. For this purpose, zebrafish were acclimated at 26 °C or 31 °C for 4 weeks and some fish acclimated at 26 °C underwent 2 ...
DOI:
10.1016/j.cbpa.2022.111299

25. Accumulation, metabolites formation and elimination behavior of rac-glufosinate-ammonium and glufosinate-P in zebrafish (Danio rerio)

Author:
Fei Wang; Qiao Lin; Xueqin Shi; Yunfang Li; Pengyu Deng; Yuping Zhang; Deyu Hu
Source:
Food chemistry: X 2022 v.15 pp. 100383
ISSN:
2590-1575
Subject:
Danio rerio; bioaccumulation factor; enantiomers; fish; food chemistry; food safety; glufosinate; glutamic acid; half life; mass spectrometry; metabolites; methylene chloride; oases; phosphorous acid
Abstract:
... An efficient trace detection method for the determination of residues of the glufosinate enantiomers and metabolites in zebrafish by HPLC–Q-Exactive Orbitrap Mass Spectrometry was developed. After the purification of dichloromethane and Oasis PRiME HLB SPE column, the recovery ranges from 77% to 104%, with RSD < 10.03%. The limits of quantitation in zebrafish were 0.006–0.02 mg/kg. The results rev ...
DOI:
10.1016/j.fochx.2022.100383

26. Acetalated dextran microparticles for the smart delivery of pyraclostrobin to control Sclerotinia diseases

Author:
Zhengang Xie; Wenlong Liang; Qiuyu Xiong; Yanyan Zhao; Jingli Cheng; Xianbin Li; Jinhao Zhao
Source:
Carbohydrate polymers 2022 v.291 pp. 119576
ISSN:
0144-8617
Subject:
Danio rerio; acute exposure; acute toxicity; antifungal properties; biopolymers; dextran; disease control; half life; photolysis; pyraclostrobin
Abstract:
... Dextran has emerged as a promising biopolymer carrier for controlled release formulations of pesticides. In this study, pH-sensitive acetalated dextran microparticles (Pyr@Ac-Dex) are prepared to encapsulate and control the release of pyraclostrobin (Pyr). In vitro fungicidal activity experiments showed that the prepared Pyr@Ac-Dex particles show comparable fungicidal ability against S. sclerotior ...
DOI:
10.1016/j.carbpol.2022.119576

27. Acetaminophen Disrupts the Development of Pharyngeal Arch-Derived Cartilage and Muscle in Zebrafish

Author:
Derrick M. Glasco; Zhidong Wang; Seonwoo Kang; Avery T. Funkhouser
Source:
Journal of developmental biology 2022 v.10 no.3 pp. -
ISSN:
2221-3759
Subject:
Danio rerio; acetaminophen; apoptosis; cartilage; chondrogenesis; collagen; embryogenesis; lethal dose; liver; muscles; neural crest; pharynx
Abstract:
... Acetaminophen is a common analgesic, but its potential effects on early embryonic development are not well understood. Previous studies using zebrafish (Danio rerio) have described the effects of acetaminophen on liver development and physiology, and a few have described gross physiological and morphological defects. Using a high but non-embryonic lethal dose of acetaminophen, we probed for defect ...
DOI:
10.3390/jdb10030030

28. Activation of Atg7-dependent autophagy by a novel inhibitor of the Keap1–Nrf2 protein–protein interaction from Penthorum chinense Pursh. attenuates 6-hydroxydopamine-induced ferroptosis in zebrafish and dopaminergic neurons

Author:
Yiran Sun; Libo He; Wang Wang; Zhishen Xie; Xiaowei Zhang; Pan Wang; Lan Wang; Chenchen Yan; Zhiwen Liu; Jie Zhao; Zhenghao Cui; Yida Wang; Lin Tang; Zhenqiang Zhang
Source:
Food & function 2022 v.13 no.14 pp. 7885-7900
ISSN:
2042-650X
Subject:
Danio rerio; Kelch repeats; Parkinson disease; Penthorum chinense; autophagy; death; ferroptosis; glutathione; heme oxygenase (biliverdin-producing); humans; lipid peroxidation; neuroprotective effect; polyphenols; protein content; protein-protein interactions
Abstract:
... The death of dopaminergic neurons is a dominant factor during the occurrence and development of Parkinson's disease (PD). Previous studies demonstrated that ferroptosis is implicated in the death of dopaminergic neurons. Besides, polyphenols have been proven to be effective in preventing the death of dopaminergic neurons. This work aims to explore the neuroprotective effect and mechanism of thonni ...
DOI:
10.1039/d2fo00357k

29. Activation of peroxymonosulfate by palygorskite-mediated cobalt-copper-ferrite nanoparticles for bisphenol S degradation: Influencing factors, pathways and toxicity evaluation

Author:
Yabin Li; Jingyao Qi; Yang Shen; Jimin Shen; Li Li; Jing Kang; Pengwei Yan; Binyuan Wang; Xinwei Zhu; Shengxin Zhao; Zhonglin Chen
Source:
Chemosphere 2022 v.308 pp. 136264
ISSN:
0045-6535
Subject:
Danio rerio; adsorption; adults; bisphenol S; catalysts; dissociation; energy; intestines; liver; males; nanoparticles; oxidation; palygorskite; testes; toxicity; water treatment
Abstract:
... Peroxymonosulfate (PMS)-based advanced oxidation process is considered a potential technology for water treatment. Here, palygorskite (PAL)-mediated cobalt-copper-ferrite nanoparticles (16%-CoCu₀.₄Fe₁·₆O₄@PAL, donated as 16%-CCFO@PAL) were employed for PMS activation to remove bisphenol S (BPS). BPS degradation was greater than 99% under the optimal conditions within 25 min, on which the effects o ...
DOI:
10.1016/j.chemosphere.2022.136264

30. Acute Toxicity Evaluation of the Disinfectant Containing Percarbonate and Tetraacetylethylenediamine by Measuring Behavioral Responses of Small Fish Using Image Analysis

Author:
Seung-Yoon Seo; Yeon-Ho Park; Sang-Kyu Jung; Jinku Kim
Source:
Biotechnology and bioprocess engineering 2022 v.27 no.4 pp. 687-696
ISSN:
1226-8372
Subject:
Danio rerio; acute toxicity; bioprocessing; biotechnology; compliance; death; disinfectants; dissolved oxygen; fish; image analysis; lethal concentration 50; pH; survival rate
Abstract:
... Disinfectants containing percarbonate and tetraacetylethylenediamine (TAED) has been developed as an effective and relatively safe disinfectant to destroy viruses and bacteria in animals and humans, however it is known that most disinfectants can cause danger to living organisms including humans. In the current study, acute toxicity of the disinfectant composed of percarbonate and TAED was assesse ...
DOI:
10.1007/s12257-021-0419-0

31. Acute and Chronic Effects of Fin Amputation on Behavior Performance of Adult Zebrafish in 3D Locomotion Test Assessed with Fractal Dimension and Entropy Analyses and Their Relationship to Fin Regeneration

Author:
Gilbert Audira; Michael Edbert Suryanto; Kelvin H.-C. Chen; Ross D. Vasquez; Marri Jmelou M. Roldan; Chun-Chuen Yang; Chung-Der Hsiao; Jong-Chin Huang
Source:
Biology 2022 v.11 no.7 pp. -
ISSN:
2079-7737
Subject:
Danio rerio; adults; amputation; analgesia; drugs; entropy; fins; fish; fractal dimensions; genomics; lidocaine; locomotion; pain; tail
Abstract:
... The fin is known to play an important role in swimming for many adult fish, including zebrafish. Zebrafish fins consist of paired pectoral and pelvic with unpaired dorsal, anal, and caudal tail fins with specific functions in fish locomotion. However, there was no study comparing the behavior effects caused by the absence of each fin. We amputated each fin of zebrafish and evaluated their behavior ...
DOI:
10.3390/biology11070969

32. Acute and developmental toxic effects of mono-halogenated and halomethyl naphthalenes on zebrafish (Danio rerio) embryos: Cardiac malformation after 2-bromomethyl naphthalene exposure

Author:
Jungeun Park; Yurim Kim; Hwang-Ju Jeon; Kyeongnam Kim; Chaeeun Kim; Seungki Lee; Jino Son; Sung-Eun Lee
Source:
Environmental pollution 2022 v.297 pp. 118786
ISSN:
0269-7491
Subject:
Danio rerio; abnormal development; body length; calcium channels; edema; genes; metabolites; naphthalene; natriuretic peptides; pericardium; pollution; toxicity
Abstract:
... Polyhalogenated polycyclic aromatic hydrocarbons (HPAHs) represent a major environmental concern due to their persistency and toxicity. Among them, mono-halogenated (HNs) and halomethyl naphthalenes (HMNs) are not well-studied, and the toxicity of many HNs to fishes has not been reported. In this study, we exposed zebrafish (Danio rerio) embryos to naphthalene and five HNs at concentrations rangin ...
DOI:
10.1016/j.envpol.2021.118786

33. Acute exposure to environmentally relevant concentrations of sucralose disrupts embryonic development and leads to an oxidative stress response in Danio rerio

Author:
Karla Colín-García; Gustavo Axel Elizalde-Velázquez; Leobardo Manuel Gómez-Oliván; Hariz Islas-Flores; Sandra García-Medina; Marcela Galar-Martínez
Source:
Science of the total environment 2022 v.829 pp. 154689
ISSN:
0048-9697
Subject:
Danio rerio; abnormal development; acute exposure; caspase-3; caspase-9; catalase; death; deformation; drugs; dwarfing; edema; embryogenesis; eyes; fish; gene expression; humans; hydroperoxides; lipid peroxidation; oxidative stress; pericardium; scoliosis; stress response; sucralose; superoxide dismutase; tail; toxicity; wastewater treatment
Abstract:
... Sucralose (SUC) is the most consumed artificial sweetener worldwide, not metabolized by the human body, and barely eliminated from water in wastewater treatment plants. Although different studies have reported high concentrations of this sweetener in aquatic environments, limited to no information is known about the toxic effects this drug may produce over water organisms. Moreover, most of the cu ...
DOI:
10.1016/j.scitotenv.2022.154689

34. Acute exposure to polystyrene nanoplastics impairs skin cells and ion regulation in zebrafish embryos

Author:
Phunsin Kantha; Sian-Tai Liu; Jiun-Lin Horng; Li-Yih Lin
Source:
Aquatic toxicology 2022 v.248 pp. 106203
ISSN:
0166-445X
Subject:
Danio rerio; acute exposure; ammonia; body fluids; calcium; cell death; excretion; fish; gene expression; homeostasis; ion transport; keratinocytes; mitochondria; nanoplastics; oxidative stress; pH; polystyrenes; reactive oxygen species; survival rate; toxicology
Abstract:
... The presence of nanoplastics in aquatic environments is a global problem. Accumulating evidence shows that nanoplastics can accumulate in fish and influence internal organs. However, it is still unknown if nanoplastics can impair skin cells (keratinocytes and ionocytes), which play critical roles in maintaining body fluid homeostasis. In the present study, zebrafish embryos were exposed to polysty ...
DOI:
10.1016/j.aquatox.2022.106203

35. Acute toxicity of broflanilide on neurosecretory system and locomotory behavior of zebrafish (Danio rerio)

Author:
Kai Wang; Chengju Wang; Jiahong Wang; Yufei Dong; Wunan Che; Xiuwei Li
Source:
Chemosphere 2022 v.305 pp. 135426
ISSN:
0045-6535
Subject:
Danio rerio; NAD (coenzyme); acute toxicity; adenosine triphosphate; apoptosis; cerebellum; deformation; dopamine; fish; fish behavior; gamma-aminobutyric acid; glutamate decarboxylase; glutamic acid; histopathology; insecticides; lethal concentration 50; metabolites; neurosecretory system; neurotransmitters
Abstract:
... Broflanilide, a novel meta-diamide insecticide, possesses moderate acute toxicity to zebrafish, with a 96-h median lethal concentration (96-LC₅₀) of 0.76 mg/L. However, its effect on fish behavior and the underlying mechanisms are still unclear. The present study evaluated the effects of broflanilide on the zebrafish brain over a 96-h exposure by comparing the histopathological changes and relativ ...
DOI:
10.1016/j.chemosphere.2022.135426

36. Acute toxicity of polychlorinated diphenyl ethers (PCDEs) in three model aquatic organisms (Scenedesmus obliquus, Daphnia magna, and Danio rerio) of different trophic levels

Author:
Wenhui Yang; Xinxin Huang; Qiuxuan Wu; Jiaqi Shi; Xuesheng Zhang; Lingwen Ouyang; Doug Crump; Xiaowei Zhang; Rui Zhang
Source:
Science of the total environment 2022 v.805 pp. 150366
ISSN:
0048-9697
Subject:
Danio rerio; Daphnia magna; Scenedesmus obliquus; acute toxicity; biphenyl; dose response; energy; environment; growth retardation; mortality; polychlorinated biphenyls; quantitative structure-activity relationships
Abstract:
... The frequent detection of polychlorinated diphenyl ethers (PCDEs) in aquatic systems has aroused widespread concerns, however, their potential hazard to aquatic ecosystems has been poorly understood. Here the acute toxicity of 12 PCDE congeners was evaluated in three model aquatic organisms representing different trophic levels following OECD test guidelines, including green algae (Scenedesmus obl ...
DOI:
10.1016/j.scitotenv.2021.150366

37. Adverse effects of SYP-3343 on zebrafish development via ROS-mediated mitochondrial dysfunction

Author:
Guoliang Chen; Mingxing Wang; Panpan Zhu; Guixue Wang; Tingzhang Hu
Source:
Journal of hazardous materials 2022 v.437 pp. 129382
ISSN:
0304-3894
Subject:
Danio rerio; acetylcysteine; apoptosis; cell cycle; embryotoxicity; heart; heart rate; membrane potential; mitochondria; mitochondrial membrane; mortality; oxygen; protein content; pyraoxystrobin; reactive oxygen species; toxins
Abstract:
... As a newly-invented and highly-efficiency strobilurin fungicide, pyraoxystrobin (SYP-3343) has been recognized as a highly poisonous toxin for a variety of aquatic organisms. Nevertheless, the developmental toxicity and potential mechanism of SYP-3343 have not been well-documented. The results showed that SYP-3343 was relatively stable and maintained within the range of 20 % in 24 h, and the LC₅₀ ...
DOI:
10.1016/j.jhazmat.2022.129382

38. Aerophobin-1 from the Marine Sponge Aplysina aerophoba Modulates Osteogenesis in Zebrafish Larvae

Author:
Marta Carnovali; Maria Letizia Ciavatta; Ernesto Mollo; Vassilios Roussis; Giuseppe Banfi; Marianna Carbone; Massimo Mariotti
Source:
Marine drugs 2022 v.20 no.2 pp. -
ISSN:
1660-3397
Subject:
Danio rerio; Porifera; bone formation; longevity; medicine; metabolites; mineralization; models; osteoporosis; skeletal development; therapeutics
Abstract:
... Longer life expectancy has led to an increase in efforts directed to the discovery of new healing agents for disorders related to aging, such as bone diseases. Harboring an incredible variety of bioactive metabolites, marine organisms are standing out as fruitful sources also in this therapeutic field. On the other hand, the in vivo zebrafish model has proven to be an excellent low-cost screening ...
DOI:
10.3390/md20020135

39. Affinity purification of in vivo assembled whirlin-associated protein complexes from the zebrafish retina

Author:
R.T.W. Schellens; R.W.N. Slijkerman; L. Hetterschijt; T.A. Peters; S. Broekman; A. Clemént; M. Westerfield; J.B. Phillips; K. Boldt; H. Kremer; E. De Vrieze; E. Van Wijk
Source:
Journal of proteomics 2022 v.266 pp. 104666
ISSN:
1874-3919
Subject:
Danio rerio; adults; genes; genetically modified organisms; humans; mass spectrometry; pathogenesis; phenotype; photoreceptors; protein-protein interactions; proteome; proteomics; retina; retinal degeneration; synapse; two hybrid system techniques
Abstract:
... Mutations in WHRN lead to Usher syndrome type 2d or to non-syndromic hearing impairment. The WHRN-encoded gene product whirlin directly interacts with the intracellular regions of the other two Usher syndrome type 2-associated proteins, usherin and ADGRV1. In photoreceptor cells, this protein complex constitutes fibrous links between the periciliary membrane and the connecting cilium. However, the ...
DOI:
10.1016/j.jprot.2022.104666

40. Alcohol exposure and environmental enrichment effects on contextual fear conditioning in zebrafish

Author:
Fabiano P. Menezes; Ricardo R. Amorim; Priscila F. Silva; Ana C. Luchiari
Source:
Behavioural processes 2022 v.197 pp. 104608
ISSN:
0376-6357
Subject:
Danio rerio; alcohol abuse; alcohols; anxiety; dose response; environmental enrichment; experimental design; fearfulness; fish
Abstract:
... Environmental enrichment effectively reduces anxiety-like indicators in animals, a potential co-treatment for diseases that generate variations in basal anxiety, such as alcoholism. Here we present an experimental design that allows investigating the effect of enrichment on anxiety-related behaviors using contextual aversive conditioning in zebrafish (Danio rerio). It was first observed whether an ...
DOI:
10.1016/j.beproc.2022.104608

41. Alleviative effects of a novel strain Bacillus coagulans XY2 on copper-induced toxicity in zebrafish larvae

Author:
Fang Ai; Xuedi Huang; Yalan Wu; Chen Ji; Yufang Gao; Ting Yu; Fujie Yan
Source:
Journal of environmental sciences (China) 2023 v.125 pp. 750-760
ISSN:
1001-0742
Subject:
Bacillus coagulans; Danio rerio; antioxidant activity; genes; human health; humans; inflammation; interleukin-10; intestines; metabolism; models; mortality; neutrophils; oxidative stress; pollutants; probiotics; toxicity; transcription (genetics); China
Abstract:
... Copper (Cu) is a kind of micronutrient element that is essential for human metabolism. However, it is also considered as an environmental pollutant which is toxic to organisms at a high concentration level. Probiotics, regarded as beneficial microorganisms for promoting human health, have functions of antioxidant capacity, immune-enhancing properties, intestinal barrier protection and regulation. ...
DOI:
10.1016/j.jes.2022.02.010

42. Aluminium exposure leads to neurodegeneration and alters the expression of marker genes involved to parkinsonism in zebrafish brain

Author:
Teresa Capriello; Gianluca Di Meglio; Anna De Maio; Rosaria Scudiero; Anna Rita Bianchi; Marco Trifuoggi; Maria Toscanesi; Antonella Giarra; Ida Ferrandino
Source:
Chemosphere 2022 v.307 pp. 135752
ISSN:
0045-6535
Subject:
DNA damage; Danio rerio; Parkinson disease; adults; aluminum; animal models; brain; etiology; histology; humans; metabolism; myelin sheath; neurotoxicity; parenchyma (animal tissue); quantitative polymerase chain reaction
Abstract:
... Aluminium, despite being extremely widespread in the world, is a non-essential metal to human metabolism. This metal is known to have toxic effects on a variety of organs including the brain and is considered an etiological factor in neurodegenerative diseases. However, the molecular mechanisms by which aluminium exerts neurotoxic effects are not yet completely understood. Zebrafish is an animal m ...
DOI:
10.1016/j.chemosphere.2022.135752

43. Ambient temperature structures the gut microbiota of zebrafish to impact the response to radioactive pollution

Author:
Bin Wang; Shu-qin Zhang; Jia-li Dong; Yuan Li; Yu-xiao Jin; Hui-wen Xiao; Hai-chao Wang; Sai-jun Fan; Ming Cui
Source:
Environmental pollution 2022 v.293 pp. 118539
ISSN:
0269-7491
Subject:
Danio rerio; ambient temperature; antibiotics; climate change; fish; intestinal microorganisms; intestines; radioactive pollution; temperature profiles; toxicity
Abstract:
... Potential nuclear accidents propel serious environmental pollution, and the resultant radionuclide release devastates severely the environment severely and threatens aquatic organism survival. Likewise, ongoing climate change coupled with the gradual increase in global surface temperatures can also adversely impact the aquatic ecosystems. In the present study, we preconditioned zebrafish (Danio re ...
DOI:
10.1016/j.envpol.2021.118539

44. Ameliorative effect of Gastrodia elata Blume extracts on depression in zebrafish and cellular models through modulating reticulon 4 receptors and apoptosis

Author:
Rongchun Wang; Qingyu Ren; Daili Gao; Yam Nath Paudel; Xia Li; Lizhen Wang; Pengyu Zhang; Baokun Wang; Xueliang Shang; Meng Jin
Source:
Journal of ethnopharmacology 2022 v.289 pp. 115018
ISSN:
0378-8741
Subject:
Danio rerio; Gastrodia elata; Oriental traditional medicine; Western blotting; adults; antidepressants; apoptosis; cell viability; diet; fluorescent antibody technique; gene expression; models; pharmacology; protein synthesis; China
Abstract:
... Gastrodia elata Blume (G. elata), a traditional Chinese herb, known as “Tian Ma”, is widely used as a common medicine and diet ingredient for treating or preventing neurological disorders for thousands of years in China. However, the anti-depressant effect of G. elata and the underlying mechanism have not been fully evaluated. The study is aimed to investigate the anti-depressant effect and the mo ...
DOI:
10.1016/j.jep.2022.115018

45. Ammonia in the presence of nano titanium dioxide (nano-TiO2) induces greater oxidative damage in the gill and liver of female zebrafish

Author:
Honghui Guo; Yu Kuang; Kang Ouyang; Ce Zhang; Hui Yang; Siqi Chen; Rong Tang; Xi Zhang; Dapeng Li; Li Li
Source:
Ecotoxicology and environmental safety 2022 v.236 pp. 113458
ISSN:
0147-6513
Subject:
Danio rerio; absorption; adults; ammonia; ammonium nitrogen; aqueous solutions; ecotoxicology; females; fish; fish health; histopathology; liver; oxidative stress; risk; titanium dioxide; toxicity; water pollution
Abstract:
... Water pollution caused by a highly hazardous chemical ammonia and a widespread application nanomaterials-nano titanium dioxide (n-TiO₂) in nature water has attracted extensive concern of the world. However, the potential joint effects of the two factors are unknown. Aim to investigate the potential interactive effects of ammonia and n-TiO₂ and the behind mechanisms, adult female zebrafish (Danio r ...
DOI:
10.1016/j.ecoenv.2022.113458

46. Analysis of the Expression of Neurotrophins and Their Receptors in Adult Zebrafish Kidney

Author:
Pietro Cacialli; Carla Lucini
Source:
Veterinary sciences 2022 v.9 no.6 pp. -
ISSN:
2306-7381
Subject:
Danio rerio; adults; fish; hybridization; immunohistochemistry; mammals; neurons; neurotrophins; renal tubules
Abstract:
... Neurotrophins and their receptors are involved in the development and maintenance of neuronal populations. Different reports have shown that all neurotrophin/receptor pathways can also play a role in several non-neuronal tissues in vertebrates, including the kidney. These signaling pathways are involved in different events to ensure the correct functioning of the kidney, such as growth, differenti ...
DOI:
10.3390/vetsci9060296

47. Analysis of the mast cell expressed carboxypeptidase A3 and its structural and evolutionary relationship to other vertebrate carboxypeptidases

Author:
Srinivas Akula; Lars Hellman; Francesc Xavier Avilés; Sara Wernersson
Source:
Developmental and comparative immunology 2022 v.127 pp. 104273
ISSN:
0145-305X
Subject:
Danio rerio; asthma; bioinformatics; carboxypeptidases; gene duplication; genes; humans; immunology; loci; mast cells; phylogeny; proteinases
Abstract:
... Metallo-carboxypeptidases are exopeptidases with diverse expression and function, found in all kingdoms of life from bacteria to mammals. One of them, the carboxypeptidase A3 (CPA3), has become an important component of the mammalian immune system by its expression in mast cells. Mast cells (MCs) are highly specialized sentinel cells, which store large amounts of bioactive mediators, including CPA ...
DOI:
10.1016/j.dci.2021.104273

48. Antagonism of Cyanamide-3-O-glucoside and protocatechuic acid on Aflatoxin B1-induced toxicity in zebrafish larva (Danio rerio)

Author:
Tian Wu; Tingting Fan; Yanli Xie
Source:
Toxicon 2022 v.216 pp. 139-147
ISSN:
0041-0101
Subject:
Danio rerio; absorption; antagonism; antioxidants; apoptosis; atrophy; biomarkers; blood serum; caspase-3; caspase-9; catalase; coculture; glutathione; hepatotoxicity; liver; metabolites; models; oxidative stress; poisoning; protocatechuic acid; superoxide dismutase; yolk sac
Abstract:
... The zebrafish model was used to evaluate the antioxidant properties of cyanidin-3-O-glucoside (C₃G) and its metabolite protocatechuic acid (PCA) against aflatoxin B₁ (AFB₁)-induced hepatotoxicity and oxidative stress. In this study, zebrafish larvae were cultured for 3 days post fertilization (dpf) and then induced with AFB₁. After induced 4 h, 8 h, 12 h, and 24 h, 5 μg/mL C₃G/PCA was added and th ...
DOI:
10.1016/j.toxicon.2022.06.009

49. Antagonistic effects and mechanisms of carbendazim and chlorpyrifos on the neurobehavior of larval zebrafish

Author:
Wanjun Zhang; Ruiqi Fan; Sunlin Luo; Ying liu; Yongpeng Jin; Yongchen Li; Mengqin Xiong; Xiaoyan Yuan; Li Jia; Yiqiang Chen
Source:
Chemosphere 2022 v.293 pp. 133522
ISSN:
0045-6535
Subject:
Danio rerio; antagonism; antigens; apoptosis; autophagy; calcium; carbendazim; chlorpyrifos; developmental toxicity; food safety; metabolism; nervous system; phototransduction; protein-protein interactions; sequence analysis; transcriptomics; vitamin A
Abstract:
... Residues from multiple pesticides are frequently detected on vegetables, which may produce combined toxicity not predicted by individual toxicity data. As these combined effects present additional dangers to food safety, we have compared individual to combined effects for a variety of pesticides. Carbendazim and chlorpyrifos are the two most commonly detected pesticides in vegetables, and previous ...
DOI:
10.1016/j.chemosphere.2022.133522

50. Anti-hyperglycemic potential of alginate oligosaccharide in a high glucose-induced zebrafish model

Author:
Hyo Hee Kim; Bipin Vaidya; Se-Young Cho; Joseph Kwon; Duwoon Kim
Source:
Journal of functional foods 2022 v.94 pp. 105098
ISSN:
1756-4646
Subject:
Danio rerio; alginates; blood glucose; energy metabolism; gene expression; glucose; glycemic effect; hyperglycemia; hypoxia; insulin receptors; lactate dehydrogenase; lactic acid; models; mortality; oligosaccharides; oxidation; proteomics; pyruvate dehydrogenase (acetyl-transferring) kinase; pyruvate dehydrogenase (lipoamide); sirtuins; therapeutics
Abstract:
... The anti-hyperglycemic activity of alginate oligosaccharide (AOS) and its mechanism were elucidated in a hyperglycemic zebrafish model. The model was prepared by inducing high glucose in zebrafish for the study. AOS treatment significantly reduced blood glucose level and delayed mortality in hyperglycemic zebrafish. To explain the anti-hyperglycemic mechanism of AOS, a comparative proteomic analys ...
DOI:
10.1016/j.jff.2022.105098