Subject term: 3 selected - PubAg Search Results

Author:: Yaping Liu; Yumeng Li; Wenlingzi Zhang; Mingzhe Sun; Zesheng Zhang
Source:: Journal of functional foods 2019 v.55 pp. 381-390
ISSN:: 1756-4646
Subject:: Ganoderma lucidum; glucose; glycemic effect; glycogen; high fat diet; hypoglycemia; insulin resistance; inulin; lipid metabolism; messenger RNA; noninsulin-dependent diabetes mellitus; nutrient transport; rats; streptozotocin
Abstract:: ... It has been reported that both inulin and ganoderma lucidum polysaccharides are conducive to glucose metabolism. The aim of present study was to explore the hypoglycemia effect and molecular mechanism of the inulin combined with ganoderma lucidum polysaccharides in type 2 diabetic mellitus (T2DM) rats. T2DM rats were induced by high fat diet (HFD) and streptozotocin (STZ). Then the inulin and gano ...
DOI:: 10.1016/j.jff.2019.02.036
: https://doi.org/10.1016/j.jff.2019.02.036

Author:: Zhou Yang; Fan Wu; Yanming He; Qiang Zhang; Yuan Zhang; Guangrong Zhou; Hongjie Yang; Ping Zhou
Source:: Food & function 2018 v.9 no.1 pp. 397-406
ISSN:: 2042-650X
Subject:: 2-deoxyglucose; AMP-activated protein kinase; Ganoderma lucidum; blood glucose; body weight; confocal laser scanning microscopy; dephosphorylation; flow cytometry; gene expression; glucose; glucose transporters; glycemic effect; insulin; insulin receptor substrate proteins; insulin resistance; messenger RNA; mice; myoblasts; non-specific serine/threonine protein kinase; noninsulin-dependent diabetes mellitus; permeability; phosphatidylinositol 3-kinase; phosphorylation; plasma membrane; protein-tyrosine-phosphatase; proteoglycans; rats; signal transduction; skeletal muscle
Abstract:: ... Insulin resistance caused by the overexpression of protein tyrosine phosphatase 1 B (PTP1B) as well as the dephosphorylation of its target is one of the main causes of type 2 diabetes (T2D). A newly discovered proteoglycan, Fudan-Yueyang Ganoderma lucidum (FYGL) extracted from Ganoderma lucidum, was first reported to be capable of competitively inhibiting PTP1B activity in vitro in our previous wo ...
DOI:: 10.1039/c7fo01489a
: https://doi.org/10.1039/c7fo01489a

Author:: Chun Xiao; Qingping Wu; Jumei Zhang; Yizhen Xie; Wen Cai; Jianbin Tan
Source:: Journal of ethnopharmacology 2017 v.196 pp. 47-57
ISSN:: 0378-8741
Subject:: Fourier transform infrared spectroscopy; Ganoderma lucidum; Western blotting; acetyl-CoA carboxylase; animal disease models; blood glucose; blood serum; carbohydrate structure; epididymis; fasting; fatty-acid synthase; gas chromatography-mass spectrometry; gene expression regulation; glucose; glucose transporters; glycemic effect; insulin; insulin resistance; liver; mechanism of action; messenger RNA; mice; molecular weight; noninsulin-dependent diabetes mellitus; nuclear magnetic resonance spectroscopy; polysaccharides; quantitative polymerase chain reaction; resistin; traditional medicine
Abstract:: ... Ganoderma lucidum (Lin Zhi) has been used to treat diabetes in Chinese folk for centuries. Our laboratory previously demonstrated that Ganoderma lucidum polysaccharides (GLPs) had hypoglycemic effects in diabetic mice. Our aim was to identify the main bioactives in GLPs and corresponding mechanism of action.Four polysaccharide-enriched fraction were isolated from GLPs and the antidiabetic activiti ...
DOI:: 10.1016/j.jep.2016.11.044
: https://doi.org/10.1016/j.jep.2016.11.044

Author:: Chun XiaoJoint first authors.; Qingping Wu; Yizhen Xie; Jianbin Tan; YinRun Ding; Lijuan Bai
Source:: Food & function 2018 v.9 no.12 pp. 6495-6507
ISSN:: 2042-650X
Subject:: Ganoderma lucidum; Western blotting; animal disease models; cluster analysis; cytochrome P-450; functional foods; gene expression; gene expression regulation; gene ontology; genes; glucokinase; gluconeogenesis; glucose; glucose transporters; glucose-6-phosphatase; glycemic effect; glycolysis; ingredients; insulin; lipid metabolism; liver; mechanism of action; messenger RNA; mice; microRNA; non-specific protein-tyrosine kinase; noninsulin-dependent diabetes mellitus; peroxisome proliferator-activated receptors; polypeptides; polysaccharides; protein synthesis; proteomics; pyruvate kinase; quantitative polymerase chain reaction; sequence analysis; signal transduction; stearoyl-CoA desaturase; transcriptomics
Abstract:: ... Our team has previously demonstrated that Ganoderma lucidum polysaccharides F31 have hypoglycemic effects on diabetic mice. This study provides insight into the system-level hypoglycemic mechanisms of F31 by the integrative analysis of transcriptomics and proteomics data. To explore the omics perspective for the mechanisms of action, the protein and gene expression in the liver from the normal con ...
DOI:: 10.1039/c8fo01656a
: https://doi.org/10.1039/c8fo01656a

Author:: Tanya T. W. Chu; Iris F. F. Benzie; Christopher W. K. Lam; Benny S. P. Fok; Kenneth K. C. Lee; Brian Tomlinson
Source:: British journal of nutrition 2012 v.107 no.7 pp. 1017-1027
ISSN:: 1475-2662
Subject:: Ganoderma lucidum; antioxidant activity; antioxidants; blood lipids; blood plasma; blood pressure; body mass index; body weight; cardioprotective effect; catecholamines; cortisol; cross-over studies; diabetes; glucose; glycemic effect; high density lipoprotein cholesterol; homeostasis; humans; hyperglycemia; hyperlipidemia; hypertension; insulin; models; patients; placebos; therapeutics; urine
Abstract:: ... Previous studies have suggested that Lingzhi (Ganoderma lucidum) has antioxidant effects and possibly beneficial effects on blood pressure, plasma lipids and glucose, but these have not been confirmed in subjects with mild hypertension or hyperlipidaemia. The objective of the present study was to assess the cardiovascular, metabolic, antioxidant and immunomodulatory responses to therapy with Lingz ...
DOI:: 10.1017/S0007114511003795
PubMed:: 21801467
: https://doi.org/10.1017/S0007114511003795

Main content area