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Ganoderma lucidum
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- Author:
- Da Hye Ryu; Jwa Yeong Cho; Nooruddin Bin Sadiq; Jin-Chul Kim; Bokyung Lee; Muhammad Hamayun; Taek Sung Lee; Hyoung Seok Kim; Soo Hyun Park; Chu Won Nho; Ho-Youn Kim
- Source:
- Food chemistry 2021 v.335 pp. 127645
- ISSN:
- 0308-8146
- Subject:
- Ganoderma lucidum; anti-inflammatory activity; antioxidant activity; antioxidants; cytokines; extraction; food chemistry; freeze drying; ganoderic acid; glycemic effect; heat; inflammation; polysaccharides; principal component analysis; response surface methodology
- Abstract:
- ... The dried Ganoderma lucidum (GL) has been widely used for its pharmacological properties and bioactive ganoderic acids (GAs). Herein, extraction procedures combining ultra-sonication and heating were optimized using response surface methodology based on four variables (antioxidant activity, anti-diabetic activity, total GAs content, and total polysaccharide content) and principal component analysi ...
- DOI:
- 10.1016/j.foodchem.2020.127645
- https://doi.org/10.1016/j.foodchem.2020.127645
- Author:
- Mingyi Chen; Dan Xiao; Wen Liu; Yunfei Song; Baorong Zou; Lin Li; Pei Li; Ying Cai; Deliang Liu; Qiongfeng Liao; Zhiyong Xie
- Source:
- International journal of biological macromolecules 2020 v.155 pp. 890-902
- ISSN:
- 0141-8130
- Subject:
- Aerococcus; Bacteroides; Dehalobacterium; Ganoderma lucidum; Proteus; Ruminococcus; amino acids; animal disease models; bacteria; bacterial communities; biodiversity; blood glucose; carbohydrate metabolism; fasting; glycemic effect; high fat diet; insulin; intestinal microorganisms; medicinal fungi; metabolites; metabolomics; noninsulin-dependent diabetes mellitus; polysaccharides; rats
- Abstract:
- ... Ganoderma lucidum polysaccharides (GLP), a kind of medicinal mushrooms, were widely used in southeastern countries with putative anti-diabetic effects. In order to unravel the underlying mechanism of its anti-diabetic effect, this study examines the effects of GLP on gut microbiota composition and functions in type 2 diabetes mellitus (T2DM) status. In this study, the effects of GLP on the gut mic ...
- DOI:
- 10.1016/j.ijbiomac.2019.11.047
- https://doi.org/10.1016/j.ijbiomac.2019.11.047
- Author:
- Yaping Liu; Yumeng Li; Wenlingzi Zhang; Mingzhe Sun; Zesheng Zhang
- Source:
- Journal of functional foods 2019 v.55 pp. 381-390
- ISSN:
- 1756-4646
- Subject:
- Ganoderma lucidum; glucose; glycemic effect; glycogen; high fat diet; hypoglycemia; insulin resistance; inulin; lipid metabolism; messenger RNA; noninsulin-dependent diabetes mellitus; nutrient transport; rats; streptozotocin
- Abstract:
- ... It has been reported that both inulin and ganoderma lucidum polysaccharides are conducive to glucose metabolism. The aim of present study was to explore the hypoglycemia effect and molecular mechanism of the inulin combined with ganoderma lucidum polysaccharides in type 2 diabetic mellitus (T2DM) rats. T2DM rats were induced by high fat diet (HFD) and streptozotocin (STZ). Then the inulin and gano ...
- DOI:
- 10.1016/j.jff.2019.02.036
- https://doi.org/10.1016/j.jff.2019.02.036
- Author:
- Li Wang; Jie-qing Li; Ji Zhang; Zhi-min Li; Hong-gao Liu; Yuan-zhong Wang
- Source:
- RSC advances 2020 v.10 no.69 pp. 42084-42097
- ISSN:
- 2046-2069
- Subject:
- Ganoderma lucidum; Human immunodeficiency virus 1; alkaloids; antioxidant activity; chemical structure; fungi; glycemic effect; heterocyclic compounds; karsts; liver; macrophages; medicinal properties; medicine; meroterpenoids; mice; neoplasm cells; polysaccharides; proteinases; research; sesquiterpenoids; splenocytes; steroids; triterpenoids; viruses
- Abstract:
- ... In recent years, some natural products isolated from the fungi of the genus Ganoderma have been found to have anti-tumor, liver protection, anti-inflammatory, immune regulation, anti-oxidation, anti-viral, anti-hyperglycemic and anti-hyperlipidemic effects. This review summarizes the research progress of some promising natural products and their pharmacological activities. The triterpenoids, merot ...
- DOI:
- 10.1039/d0ra07219b
- https://doi.org/10.1039/d0ra07219b
- Author:
- J. Vetter
- Source:
- Acta alimentaria 2019 v.48 no.2 pp. 229-240
- ISSN:
- 1588-2535
- Subject:
- Agaricus bisporus; Coprinus comatus; Ganoderma lucidum; Lentinula edodes; anticarcinogenic activity; antimicrobial properties; antioxidant activity; chemical composition; flavonoids; functional foods; ganoderic acid; glycemic effect; immune system; linoleic acid; linolenic acid; metabolism; mushrooms; patients; polysaccharides; sodium; sugars
- Abstract:
- ... Cultivated mushrooms are not only valuable foods of our age (functional foods) but contain certain beneficial chemical components (high level of K and P, very low content of Na, considerable quantities of some microelements, high and valuable protein but low fat contents). Some cultivated mushrooms have anti-carcinogenic effects caused first of all by polysaccharides (Lentinan: Lentinula edodes) a ...
- DOI:
- 10.1556/066.2019.48.2.11
- https://doi.org/10.1556/066.2019.48.2.11
- Author:
- Zhou Yang; Fan Wu; Yanming He; Qiang Zhang; Yuan Zhang; Guangrong Zhou; Hongjie Yang; Ping Zhou
- Source:
- Food & function 2018 v.9 no.1 pp. 397-406
- ISSN:
- 2042-650X
- Subject:
- 2-deoxyglucose; AMP-activated protein kinase; Ganoderma lucidum; blood glucose; body weight; confocal laser scanning microscopy; dephosphorylation; flow cytometry; gene expression; glucose; glucose transporters; glycemic effect; insulin; insulin receptor substrate proteins; insulin resistance; messenger RNA; mice; myoblasts; non-specific serine/threonine protein kinase; noninsulin-dependent diabetes mellitus; permeability; phosphatidylinositol 3-kinase; phosphorylation; plasma membrane; protein-tyrosine-phosphatase; proteoglycans; rats; signal transduction; skeletal muscle
- Abstract:
- ... Insulin resistance caused by the overexpression of protein tyrosine phosphatase 1 B (PTP1B) as well as the dephosphorylation of its target is one of the main causes of type 2 diabetes (T2D). A newly discovered proteoglycan, Fudan-Yueyang Ganoderma lucidum (FYGL) extracted from Ganoderma lucidum, was first reported to be capable of competitively inhibiting PTP1B activity in vitro in our previous wo ...
- DOI:
- 10.1039/c7fo01489a
- https://doi.org/10.1039/c7fo01489a
- Author:
- Chun Xiao; Qingping Wu; Jumei Zhang; Yizhen Xie; Wen Cai; Jianbin Tan
- Source:
- Journal of ethnopharmacology 2017 v.196 pp. 47-57
- ISSN:
- 0378-8741
- Subject:
- Fourier transform infrared spectroscopy; Ganoderma lucidum; Western blotting; acetyl-CoA carboxylase; animal disease models; blood glucose; blood serum; carbohydrate structure; epididymis; fasting; fatty-acid synthase; gas chromatography-mass spectrometry; gene expression regulation; glucose; glucose transporters; glycemic effect; insulin; insulin resistance; liver; mechanism of action; messenger RNA; mice; molecular weight; noninsulin-dependent diabetes mellitus; nuclear magnetic resonance spectroscopy; polysaccharides; quantitative polymerase chain reaction; resistin; traditional medicine
- Abstract:
- ... Ganoderma lucidum (Lin Zhi) has been used to treat diabetes in Chinese folk for centuries. Our laboratory previously demonstrated that Ganoderma lucidum polysaccharides (GLPs) had hypoglycemic effects in diabetic mice. Our aim was to identify the main bioactives in GLPs and corresponding mechanism of action.Four polysaccharide-enriched fraction were isolated from GLPs and the antidiabetic activiti ...
- DOI:
- 10.1016/j.jep.2016.11.044
- https://doi.org/10.1016/j.jep.2016.11.044
- Author:
- Zhou Yang; Fan Wu; Hongjie Yang; Ping Zhou
- Source:
- RSC advances 2017 v.7 no.66 pp. 41779-41786
- ISSN:
- 2046-2069
- Subject:
- Ganoderma lucidum; Western blotting; absorption; confocal laser scanning microscopy; endocytosis; flow cytometry; glycemic effect; human cell lines; protein-tyrosine-phosphatase; proteoglycans; signal transduction
- Abstract:
- ... A novel protein tyrosine phosphatase 1B (PTP1B) inhibitor, FYGL, extracted from Ganoderma lucidum, was first reported to have an efficient hypoglycemic effect and high safety in vivo in our previous study. However, the underlying mechanism of the anti-diabetes activity was still unclear. The dominant effective component of FYGL was demonstrated to be a neutral hyperbranched proteoglycan macromolec ...
- DOI:
- 10.1039/c7ra07520k
- https://doi.org/10.1039/c7ra07520k
9. Hypoglycemic mechanisms of Ganoderma lucidum polysaccharides F31 in db/db mice via RNA-seq and iTRAQ
- Author:
- Chun XiaoJoint first authors.; Qingping Wu; Yizhen Xie; Jianbin Tan; YinRun Ding; Lijuan Bai
- Source:
- Food & function 2018 v.9 no.12 pp. 6495-6507
- ISSN:
- 2042-650X
- Subject:
- Ganoderma lucidum; Western blotting; animal disease models; cluster analysis; cytochrome P-450; functional foods; gene expression; gene expression regulation; gene ontology; genes; glucokinase; gluconeogenesis; glucose; glucose transporters; glucose-6-phosphatase; glycemic effect; glycolysis; ingredients; insulin; lipid metabolism; liver; mechanism of action; messenger RNA; mice; microRNA; non-specific protein-tyrosine kinase; noninsulin-dependent diabetes mellitus; peroxisome proliferator-activated receptors; polypeptides; polysaccharides; protein synthesis; proteomics; pyruvate kinase; quantitative polymerase chain reaction; sequence analysis; signal transduction; stearoyl-CoA desaturase; transcriptomics
- Abstract:
- ... Our team has previously demonstrated that Ganoderma lucidum polysaccharides F31 have hypoglycemic effects on diabetic mice. This study provides insight into the system-level hypoglycemic mechanisms of F31 by the integrative analysis of transcriptomics and proteomics data. To explore the omics perspective for the mechanisms of action, the protein and gene expression in the liver from the normal con ...
- DOI:
- 10.1039/c8fo01656a
- https://doi.org/10.1039/c8fo01656a
- Author:
- Haou-Tzong Ma; Jung-Feng Hsieh; Shui-Tein Chen
- Source:
- Phytochemistry 2015 v.114 pp. 109-113
- ISSN:
- 0031-9422
- Subject:
- Ganoderma lucidum; adjuvants; aldehyde reductase; alpha-glucosidase; animal disease models; antibody detection; diabetes; glycemic effect; hyperglycemia; insulin; longevity; mice; protein-tyrosine-phosphatase; proteoglycans; sugars; triterpenoids; white-rot fungi
- Abstract:
- ... Ganoderma lucidum is a white rot fungus widely used as a tonic for the promotion of longevity and health. Extracts of G. lucidum have been recognized as an alternative adjuvant treatment for diabetes. Among the many biologically active constituents of G. lucidum, polysaccharides, proteoglycans, proteins and triterpenoids have been shown to have hypoglycemic effects. G. lucidum polysaccharides have ...
- DOI:
- 10.1016/j.phytochem.2015.02.017
- https://doi.org/10.1016/j.phytochem.2015.02.017
- Author:
- Chun Xiao; Qing-Ping Wu; Wen Cai; Jian-Bin Tan; Xiao-Bing Yang; Ju-Mei Zhang
- Source:
- Archives of pharmacal research 2012 v.35 no.10 pp. 1793-1801
- ISSN:
- 0253-6269
- Subject:
- Ganoderma lucidum; blood glucose; dose response; fasting; gene expression; genes; gluconeogenesis; glucose-6-phosphatase; glycemic effect; glycogen; glycogenolysis; insulin; liver; mechanism of action; messenger RNA; mice; noninsulin-dependent diabetes mellitus; phosphorylase; quantitative polymerase chain reaction; streptozotocin; tissue weight; white adipose tissue
- Abstract:
- ... Our aims were to investigate the hypoglycemic effects and mechanisms of action of Ganoderma lucidum polysaccharides (GLPs) administered for 7 days in type 2 diabetic mice. The mice were randomly divided into four groups (8 mice/group): normal control group, diabetic control group, low-dose GLP-treated diabetic group (50 mg/kg/d), and high-dose GLP-treated diabetic group (100 mg/kg/d). Diabetes was ...
- DOI:
- 10.1007/s12272-012-1012-z
- https://doi.org/10.1007/s12272-012-1012-z
- Author:
- Tanya T. W. Chu; Iris F. F. Benzie; Christopher W. K. Lam; Benny S. P. Fok; Kenneth K. C. Lee; Brian Tomlinson
- Source:
- British journal of nutrition 2012 v.107 no.7 pp. 1017-1027
- ISSN:
- 1475-2662
- Subject:
- Ganoderma lucidum; antioxidant activity; antioxidants; blood lipids; blood plasma; blood pressure; body mass index; body weight; cardioprotective effect; catecholamines; cortisol; cross-over studies; diabetes; glucose; glycemic effect; high density lipoprotein cholesterol; homeostasis; humans; hyperglycemia; hyperlipidemia; hypertension; insulin; models; patients; placebos; therapeutics; urine
- Abstract:
- ... Previous studies have suggested that Lingzhi (Ganoderma lucidum) has antioxidant effects and possibly beneficial effects on blood pressure, plasma lipids and glucose, but these have not been confirmed in subjects with mild hypertension or hyperlipidaemia. The objective of the present study was to assess the cardiovascular, metabolic, antioxidant and immunomodulatory responses to therapy with Lingz ...
- DOI:
- 10.1017/S0007114511003795
- PubMed:
- 21801467
- https://doi.org/10.1017/S0007114511003795
- Author:
- Han, Chunchao; Liu, Tongjun
- Source:
- Biological trace element research 2009 v.127 no.2 pp. 177-182
- ISSN:
- 0163-4984
- Subject:
- Coprinus comatus; Ganoderma lucidum; Grifola frondosa; blood glucose; glycemic effect; mice; mushrooms; people; sugars; vanadium
- Abstract:
- ... The hypoglycemic activity of fermented mushroom of three fungi of basidiomycetes rich in vanadium was studied in this paper. Alloxan- and adrenalin-induced hyperglycemic mice were used in the study. The blood glucose and the sugar tolerance were determined. After the mice were administered (ig) with Coprinus comatus rich in vanadium, the blood glucose of alloxan-induced hyperglycemic mice decrease ...
- DOI:
- 10.1007/s12011-008-8231-7
- https://doi.org/10.1007/s12011-008-8231-7