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- van der Kamp, Marc W., et al. Show all 6 Authors
- Journal of the American Chemical Society 2012 v.134 no.44 pp. 18275-18285
- Gram-negative bacteria; Serratia; active sites; beta-lactamase; crystal structure; crystallography; drugs; hydrolysis; meropenem; molecular dynamics; mutants
- ... Carbapenems are the most potent β-lactam antibiotics and key drugs for treating infections by Gram-negative bacteria. In such organisms, β-lactam resistance arises principally from β-lactamase production. Although carbapenems escape the activity of most β-lactamases, due in the class A enzymes to slow deacylation of the covalent acylenzyme intermediate, carbapenem-hydrolyzing class A β-lactamases ...