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1. Acute and sub-chronic toxicity evaluations of aqueous extract from stem bark of Grewia mollis (Malvaceae) in rats

Author:
Pongri, Adarki; Igbe, Ighodaro
Source:
Herba Polonica 2017 v.63 no.3 pp. 35-47
ISSN:
0018-0599
Subject:
Grewia mollis,   etc   ; bark; blood serum; body weight changes; cough; diarrhea; fever; food intake; heart; histopathology; kidneys; lethal dose 50; liver; lungs; oral administration; rats; rickets; spleen; traditional medicine;     Show all 19 Subjects
Abstract:
... Introduction: Different parts of Grewia mollis Juss. (Malvaceae) are commonly used in folk medicine to treat several ailments, including diarrhea, ulcers, rickets, cough and fever. Although several studies have proved its therapeutic effectiveness, there are very few toxicological studies on the plant. Objectives: This study was carried out to evaluate the acute and sub-chronic toxicity of the aqu ...
DOI:
10.1515/hepo-2017-0017

2. Hyaluronidase, phospholipase A2 and protease inhibitory activity of plants used in traditional treatment of snakebite-induced tissue necrosis in Mali, DR Congo and South Africa

Author:
Molander, Marianne; Nielsen, Line; Søgaard, Søren; Staerk, Dan; Rønsted, Nina; Diallo, Drissa; Chifundera, Kusamba Zacharie; van Staden, Johannes; Jäger, Anna K.
Source:
Journal of ethnopharmacology 2014 v.157 pp. 171-180
ISSN:
0378-8741
Subject:
Grewia mollis,   etc   ; Bauhinia thonningii; Bitis arietans; Combretum; Lannea; Naja; Strychnos; active ingredients; antiserum; bioassays; enzyme inhibition; enzyme inhibitors; ethanol; hyaluronoglucosaminidase; inhibitory concentration 50; mortality; necrosis; patients; phospholipase A2; plant anatomy; polyphenols; proteinases; snake bites; snakes; traditional medicine; Democratic Republic of the Congo; Mali; South Africa;     Show all 28 Subjects
Abstract:
... Snakebite envenomation, every year, causes estimated 5–10,000 mortalities and results in more than 5–15,000 amputations in sub-Saharan Africa alone. Antiserum is not easily accessible in these regions or doctors are simply not available, thus more than 80% of all patients seek traditional practitioners as first-choice. Therefore it is important to investigate whether the plants used in traditional ...
DOI:
10.1016/j.jep.2014.09.027

3. Investigating potential wound healing properties of polysaccharides extracted from Grewia mollis Juss. and Hoheria populnea A. Cunn. (Malvaceae)

Author:
Pearman, N.; Moxon, S.R.; Carnachan, S.M.; Cooke, M.E.; Nep, E.I.; Sims, I.M.; Morris, G.A.; Smith, A.M.
Source:
Bioactive carbohydrates and dietary fibre 2019 v.20 pp. 100201
ISSN:
2212-6198
Subject:
Grewia mollis,   etc   ; bark; chemotaxis; collagen; dietary fiber; fibroblasts; genes; histology; leaves; messenger RNA; polysaccharides; quantitative polymerase chain reaction; staining; tissue repair; traditional medicine;     Show all 15 Subjects
Abstract:
... The Malvaceae family is a group of flowering plants that include approximately 244 genera, and 4225 species. Grewia mollis, and Hoheria populnea (lacebark), are examples of the Malvaceae family that are used in traditional medicine. For this study polysaccharide samples were extracted from the inner bark of Grewia mollis (unmodified (GG) and destarched grewia gum (GGDS)) and from the leaves of Hoh ...
DOI:
10.1016/j.bcdf.2019.100201

4. Investigation of skin permeation, ex vivo inhibition of venom-induced tissue destruction, and wound healing of African plants used against snakebites

Author:
Molander, Marianne; Staerk, Dan; Mørck Nielsen, Hanne; Brandner, Johanna M.; Diallo, Drissa; Kusamba Zacharie, Chifundera; van Staden, Johannes; Jäger, Anna K.
Source:
Journal of ethnopharmacology 2015 v.165 pp. 1-8
ISSN:
0378-8741
Subject:
Grewia mollis,   etc   ; Dichrostachys cinerea; Paullinia pinnata; Tamarindus indica; antiserum; cell movement; cytotoxicity; enzymes; ethanol; models; mortality; necrosis; plant extracts; snake bites; therapeutics; tissue repair; traditional medicine; venoms; Sub-Saharan Africa;     Show all 19 Subjects
Abstract:
... Snakebite envenomation causes 5000–10,000 mortalities and results in more than 5–15,000 amputations in sub-Saharan Africa alone every year. The inaccessibility of antiserum therapy is a vast problem, and only about 2.5% of the actual need for antiserum in Africa is covered. Numerous plants have shown in vitro inhibitory activity against one or more of the hydrolytic enzymes involved in snakebite-i ...
DOI:
10.1016/j.jep.2015.02.014