PubAg

Main content area

You searched for: Subject "Hepatitis C virus" Remove constraint Subject: "Hepatitis C virus" Subject Hepatitis C virus Remove constraint Subject: Hepatitis C virus Subject viruses Remove constraint Subject: viruses
Start Over

Search

324  Search Results

« Previous | 1 - 20 of 324 |
Number of results to display per page

Search Results

1. Effectiveness of ombitasvir/paritaprevir/ritonavir, dasabuvir for HCV in HIV/HCV coinfected subjects: a comprehensive analysis

Author:
Wu, Jingjing; Huang, Peng; Fan, Haozhi; Tian, Ting; Xia, Xueshan; Fu, Zuqiang; Wang, Yan; Ye, Xiangyu; Yue, Ming; Zhang, Yun
Source:
Virology journal 2019 v.16 no.1 pp. 11
ISSN:
1743-422X
Subject:
Hepatitis C virus,   etc   ; Human immunodeficiency virus; confidence interval; genotype; immunosuppression; mixed infection; patients; viruses;     Show all 8 Subjects
Abstract:
... BACKGROUND: Data on the treatment of patients with hepatitis C virus (HCV)/human immunodeficiency virus (HIV) coinfection remains limited. A comprehensive analysis was performed to evaluate the efficacy and safety of ombitasvir (OBV)/paritaprevir (PTV)/ritonavir(r) ± dasabuvir (DSV) ± ribavirin (RBV) for treatment in HCV/HIV coinfected patients. METHODS: We systematically searched and included stu ...
DOI:
10.1186/s12985-018-1114-4

2. Hepatitis C virus genotyping based on Core and NS5B regions in Cameroonian patients

Author:
Tagnouokam-Ngoupo, Paul Alain; Ngoufack, Marie Nicole; Kenmoe, Sebastien; Lissock, Simon Frédéric; Amougou-Atsama, Marie; Banai, Robert; Ngono, Laure; Njouom, Richard
Source:
Virology journal 2019 v.16 no.1 pp. 101
ISSN:
1743-422X
Subject:
Hepatitis C virus,   etc   ; genomics; genotype; genotyping; patients; phylogeny; therapeutics; viral load; viruses; Cameroon;     Show all 10 Subjects
Abstract:
... BACKGROUND: Current HCV treatments are genotype specific although potential pan-genotype treatments have recently been described. Therefore, genotyping is an essential tool for the therapeutic management of HCV infection and a variety of technologies have been developed for HCV genotypes determination. Sequences analysis of HCV sub-genomic regions is considered as gold standard and is widely used ...
DOI:
10.1186/s12985-019-1214-9

3. Signature of natural resistance in NS3 protease revealed by deep sequencing of HCV strains circulating in Iran

Author:
Cuypers, Lize; Thijssen, Marijn; Shakibzadeh, Arash; Deboutte, Ward; Sarvari, Jamal; Sabahi, Farzaneh; Ravanshad, Mehrdad; Pourkarim, Mahmoud Reza
Source:
Infection, genetics, and evolution 2019 v.75 pp. 103966
ISSN:
1567-1348
Subject:
Hepatitis C virus,   etc   ; drugs; high-throughput nucleotide sequencing; patients; phylogeny; proteinases; screening; therapeutics; viruses; Iran;     Show all 10 Subjects
Abstract:
... A tremendous upscale of screening and treatment strategies is required to achieve elimination of the hepatitis C virus (HCV) in Iran by 2030. Among treated patients, at least 5–10% is expected to experience treatment failure. To efficiently retreat cases with prior exposure to NS5A and NS5B drugs, knowledge on the natural prevalence of NS3 resistance is key. The NS3 region of 32 samples from sixte ...
DOI:
10.1016/j.meegid.2019.103966

4. Lighting up the Native Viral RNA Genome with a Fluorogenic Probe for the Live-Cell Visualization of Virus Infection

Author:
Luo, Xingyu; Xue, Binbin; Feng, Guangfu; Zhang, Jiaheng; Lin, Bin; Zeng, Pan; Li, Huiyi; Yi, Haibo; Zhang, Xiao-Lian; Zhu, Haizhen; Nie, Zhou
Source:
Journal of the American Chemical Society 2019 v.141 no.13 pp. 5182-5191
ISSN:
1520-5126
Subject:
Hepatitis C virus,   etc   ; RNA; drugs; fluorescence; genetic engineering; genome; image analysis; monitoring; staining; viruses;     Show all 10 Subjects
Abstract:
... RNA viruses represent a major global health threat, and the visualization of their RNA genome in infected cells is essential for virological research and clinical diagnosis. Due to the lack of chemical toolkits for the live-cell imaging of viral RNA genomes, especially native viral genomes without labeling and genetic modification, studies on native virus infection at the single-live-cell level ar ...
DOI:
10.1021/jacs.8b10265

5. Net emergence of substitutions at position 28 in NS5A of hepatitis C virus genotype 4 in patients failing direct-acting antivirals detected by next-generation sequencing

Author:
Nguyen, Thuy; Akhavan, Sepideh; Caby, Fabienne; Bonyhay, Luminita; Larrouy, Lucile; Gervais, Anne; Lebray, Pascal; Poynard, Thierry; Calmus, Yvon; Simon, Anne; Valantin, Marc-Antoine; Calvez, Vincent; Marcelin, Anne-Geneviève; Todesco, Eve
Source:
International journal of antimicrobial agents 2019 v.53 no.1 pp. 80-83
ISSN:
0924-8579
Subject:
Hepatitis C virus,   etc   ; antiviral agents; genotype; guidelines; high-throughput nucleotide sequencing; mutation; patients; viruses;     Show all 8 Subjects
Abstract:
... More data on resistance of HCV genotype (GT) 3 and 4 to direct-acting antivirals (DAAs) are still needed. Here we investigated the presence of resistance-associated substitutions (RASs) pre- and post-treatment and their emergence under DAAs in HCV GT3- and GT4-infected patients failing DAA regimens by next-generation sequencing (NGS). Sanger sequencing and NGS were performed on NS5B and NS5A in pl ...
DOI:
10.1016/j.ijantimicag.2018.09.010

6. Oenothein B, dimeric hydrolysable tannin inhibiting HCV invasion from Oenothera erythrosepala

Author:
Tamura, Satoru; Yang, Gang-Ming; Koitabashi, Teruaki; Matsuura, Yoshiharu; Komoda, Yasumasa; Kawano, Tomikazu; Murakami, Nobutoshi
Source:
Natural medicines 2019 v.73 no.1 pp. 67-75
ISSN:
1340-3443
Subject:
Hepatitis C virus,   etc   ; Oenothera glazioviana; methanol; models; moieties; proteins; stereoselectivity; viruses;     Show all 8 Subjects
Abstract:
... The envelope proteins of the hepatitis C virus (HCV), E1 and E2, have been revealed to be essential for invasion of HCV. Thus, we were engaged in the search for the inhibitors against HCV invasion through the assay system using the model virus expressing recombinant HCV envelopes, E1 and E2. Now, we disclosed dimeric hydrolysable tannin oenothein B (1) from MeOH extract of Oenothera erythrosepala ...
DOI:
10.1007/s11418-018-1239-1

7. Near-Neighbor Interactions in the NS3-4A Protease of HCV Impact Replicative Fitness of Drug-Resistant Viral Variants

Author:
Doncheva, Nadezhda T.; Domingues, Francisco S.; McGivern, David R.; Shimakami, Tetsuro; Zeuzem, Stefan; Lengauer, Thomas; Lange, Christian M.; Albrecht, Mario; Welsch, Christoph
Source:
Journal of molecular biology 2019 v.431 no.12 pp. 2354-2368
ISSN:
0022-2836
Subject:
Hepatitis C virus,   etc   ; amino acid substitution; amino acids; cell culture; drug resistance; genomics; probability; proteinase inhibitors; proteinases; virion; viruses;     Show all 11 Subjects
Abstract:
... A variety of amino acid substitutions in the NS3-4A protease of the hepatitis C virus lead to protease inhibitor (PI) resistance. Many of these significantly impair the replication fitness of the resistant variants in a genotype- and subtype-dependent manner, a critical factor in determining the probability with which resistant variants will persist. However, the underlying molecular mechanisms ar ...
DOI:
10.1016/j.jmb.2019.04.034

8. Differential interaction strategies of hepatitis c virus genotypes during entry – An in silico investigation of envelope glycoprotein E2 - CD81 interaction

Author:
Bhattacharjee, Chayan; Nandy, Suman K.; Das, Pratik; Mukhopadhyay, Aparna
Source:
Infection, genetics, and evolution 2019 v.69 pp. 48-60
ISSN:
1567-1348
Subject:
Hepatitis C virus,   etc   ; amino acids; blood; chronic hepatitis; codons; energy; genotype; glycoproteins; models; pathogens; therapeutics; virulence; viruses;     Show all 13 Subjects
Abstract:
... Hepatitis C Virus is a blood borne pathogen responsible for chronic hepatitis in more than 71 million people. Wide variations across strains and genotypes are one of the major hurdles in therapeutic development. While genotype 1 remains the most extensively studied and abundant strain, genotype 3 is more virulent and second most prevalent. This study aimed to compare differences in the glycoprotei ...
DOI:
10.1016/j.meegid.2019.01.008

9. A comparative study of the efficiency of HCV NS3/4A protease drugs against different HCV genotypes using in silico approaches

Author:
Ezat, Ahmed A.; Elshemey, Wael M.
Source:
Life sciences 2019 v.217 pp. 176-184
ISSN:
0024-3205
Subject:
Hepatitis C virus,   etc   ; Gibbs free energy; antiviral agents; computer simulation; drug interactions; drugs; equipment; genotype; models; proteinases; viruses;     Show all 11 Subjects
Abstract:
... To investigate the efficacy of Direct Acting Antivirals (DAAs) in the treatment of different Hepatitis C Virus (HCV) genotypes.Homology modeling is used to predict the 3D structures of different genotypes while molecular docking is employed to predict genotype – drug interactions (Binding Mode) and binding free energy (Docking Score).Simeprevir (TMC435) and to a lesser degree MK6325 are the best d ...
DOI:
10.1016/j.lfs.2018.12.004

10. 8 years post-marketing surveillance between Asari Radix and hepatocellular carcinoma: Nationwide population-based evidence against an association

Author:
Chen, Chin-Nu; Tsai, Yueh-Ting; Lai, Jung-Nien
Source:
Journal of ethnopharmacology 2019 v.243 pp. 112094
ISSN:
0378-8741
Subject:
Hepatitis C virus,   etc   ; Asarum heterotropoides; Asarum sieboldii; aristolochic acids; cohort studies; health insurance; hepatoma; herbal medicines; monitoring; patients; traditional medicine; viruses; Taiwan;     Show all 13 Subjects
Abstract:
... Asari Radix (Xixin, Asarum heterotropoides Fr. Schmidt var. mandshuricum Kitag., Asarum sieboldii Miq., or Asarum sieboldii Miq. var. seoulense Nakai, Asarum spp.) is the only herbal medicine containing aristolochic acid that can be used in medical practice. However, scientific evidence regarding its safe use in relation to hepatocellular carcinoma (HCC) is lacking.The aim of this study was to use ...
DOI:
10.1016/j.jep.2019.112094

11. Probing and pressing surfaces of hepatitis C virus-like particles

Author:
Collett, Simon; Torresi, Joseph; Earnest-Silveira, Linda; Christiansen, Dale; Elbourne, Aaron; Ramsland, Paul A.
Source:
Journal of colloid and interface science 2019 v.545 pp. 259-268
ISSN:
0021-9797
Subject:
Hepatitis C virus,   etc   ; animals; atomic force microscopy; biomechanics; cell-mediated immunity; genotype; glycoproteins; glycosylation; hepatitis C; immune system; nanomaterials; vaccines; virion; virus-like particles; viruses;     Show all 15 Subjects
Abstract:
... Hepatitis C virus-like particles (VLPs) are being developed as a quadrivalent vaccine candidate, eliciting both humoral and cellular immune responses in animal trials. Biophysical, biomechanical and biochemical properties are important for virus and VLP interactions with host cells and recognition by the immune system. Atomic force microscopy (AFM) is a powerful tool for visualizing surface topogr ...
DOI:
10.1016/j.jcis.2019.03.022

12. The cellular stress response in hepatitis C virus infection: A balancing act to promote viral persistence and host cell survival

Author:
Ríos-Ocampo, W. Alfredo; Navas, María-Cristina; Faber, Klaas Nico; Daemen, Toos; Moshage, Han
Source:
Virus research 2019 v.263 pp. 1-8
ISSN:
0168-1702
Subject:
Hepatitis C virus,   etc   ; autophagy; cell viability; chronic hepatitis C; endoplasmic reticulum; hepatocytes; homeostasis; oxidative stress; stress response; unfolded protein response; viral proteins; virus replication; viruses;     Show all 13 Subjects
Abstract:
... Oxidative- and endoplasmic reticulum (ER)-stress are common events during hepatitis C virus (HCV) infection and both regulate cell survival and determine clinical outcome. In response to intrinsic and extrinsic cellular stress, different adaptive mechanisms have evolved in hepatocytes to restore cellular homeostasis like the anti-oxidant response, the unfolded protein response (UPR) and the integr ...
DOI:
10.1016/j.virusres.2018.12.013

13. G-Quadruplexes: More Than Just a Kink in Microbial Genomes

Author:
Saranathan, Nandhini; Vivekanandan, Perumal
Source:
Trends in microbiology 2019 v.27 no.2 pp. 148-163
ISSN:
0966-842X
Subject:
Hepatitis C virus,   etc   ; Hepatitis B virus; drug therapy; immune evasion; DNA; fungi; genes; nucleotide sequences; virus replication; viruses; antigenic variation; RNA; radiation resistance; bacteria; Human gammaherpesvirus 4;     Show all 15 Subjects
Abstract:
... G-quadruplexes (G4s) are noncanonical nucleic acid secondary structures formed by guanine-rich DNA and RNA sequences. In this review we aim to provide an overview of the biological roles of G4s in microbial genomes with emphasis on recent discoveries. G4s are enriched and conserved in the regulatory regions of microbes, including bacteria, fungi, and viruses. Importantly, G4s in hepatitis B virus ...
DOI:
10.1016/j.tim.2018.08.011

14. Molecular identification and characterization of nonprimate hepaciviruses in equines

Author:
Schlottau, Kore; Fereidouni, Sasan; Beer, Martin; Hoffmann, Bernd
Source:
Archives of virology 2019 v.164 no.2 pp. 391-400
ISSN:
0304-8608
Subject:
Hepatitis C virus,   etc   ; Cercopithecidae; Chiroptera; RNA; animal models; asses; blood serum; dogs; genes; hepatoma; horses; humans; liver cirrhosis; pathogenesis; polyproteins; rodents; screening; sequence analysis; viruses; Egypt; Germany;     Show all 21 Subjects
Abstract:
... Hepatitis C virus (HCV) is a positive-sense RNA virus belonging to the genus Hepacivirus, family Flaviviridae. Its genome has a length of 9.6 kb and encodes a single polyprotein flanked by two untranslated regions. HCV can cause liver cirrhosis and hepatocellular carcinoma, and approximately 2% of the world’s population is chronically infected. The investigation of pathogenesis is complicated due ...
DOI:
10.1007/s00705-018-4077-2

15. Plant-derived antivirals against hepatitis c virus infection

Author:
Jardim, Ana Carolina Gomes; Shimizu, Jacqueline Farinha; Rahal, Paula; Harris, Mark
Source:
Virology journal 2018 v.15 no.1 pp. 34
ISSN:
1743-422X
Subject:
Hepatitis C virus,   etc   ; human diseases; hepatitis; antiviral properties; antiviral agents; public health; vaccines; viruses; genotype; people;     Show all 10 Subjects
Abstract:
... Hepatitis C virus (HCV) infection is a worldwide public health burden and it is estimated that 185 million people are or have previously been infected worldwide. There is no effective vaccine for prevention of HCV infection; however, a number of drugs are available for the treatment of infection. The availability of direct-acting antivirals (DAAs) has dramatically improved therapeutic options for ...
DOI:
10.1186/s12985-018-0945-3
PubMed:
29439720
PubMed Central:
PMC5812025

16. Purinoceptor expression in hepatocellular virus (HCV)-induced and non-HCV hepatocellular carcinoma: an insight into the proviral role of the P2X4 receptor

Author:
Khalid, Madiha; Manzoor, Sobia; Ahmad, Hassam; Asif, Arun; Bangash, Tariq Ali; Latif, Amer; Jaleel, Shahla
Source:
Molecular biology reports 2018 v.45 no.6 pp. 2625-2630
ISSN:
0301-4851
Subject:
Hepatitis C virus,   etc   ; antibodies; color; hepatoma; immune response; immunohistochemistry; liver; patients; purinergic receptors; viruses;     Show all 10 Subjects
Abstract:
... The basic idea behind this study was to discover the association and prevalence of purinoceptors in hepatitis C virus (HCV) and non-HCV hepatocellular carcinoma (HCC). Immunohistochemistry was performed to study the expression of P2X4 and P2X7 receptors on ex-planted liver tissue samples that were collected from HCC patients. Antibodies specific for the P2X4 and P2X7 receptors were used to target ...
DOI:
10.1007/s11033-018-4432-0

17. Quasispecies dynamics and clinical significance of hepatitis C virus (HCV) antiviral resistance

Author:
Perales, Celia
Source:
International journal of antimicrobial agents 2018
ISSN:
0924-8579
Subject:
Hepatitis C virus,   etc   ; antiviral agents; genotype; high-throughput nucleotide sequencing; hosts; mutants; patients; viruses;     Show all 8 Subjects
Abstract:
... Hepatitis C virus (HCV) follows quasispecies dynamics in infected hosts and this influences its biology, how the virus diversifies into several genotypes and many subtypes, and how viral populations respond to antiviral therapies. Despite current antiviral combinations being able to cure a great percentage of HCV-infected patients, the presence of resistance-associated substitutions (RASs) diminis ...
DOI:
10.1016/j.ijantimicag.2018.10.005

18. Comparison of cobas HCV GT against Versant HCV Genotype 2.0 (LiPA) with confirmation by Sanger sequencing

Author:
Yusrina, Falah; Chua, Cui Wen; Lee, Chun Kiat; Chiu, Lily; Png, Tracy Si-Yu; Khoo, Mui Joo; Yan, Gabriel; Lee, Guan Huei; Yan, Benedict; Lee, Hong Kai
Source:
Journal of virological methods 2018 v.255 pp. 8-13
ISSN:
0166-0934
Subject:
Hepatitis C virus,   etc   ; blood serum; genotype; genotyping; therapeutics; viruses; South East Asia;     Show all 7 Subjects
Abstract:
... : Correct identification of infecting hepatitis C virus (HCV) genotype is helpful for targeted antiviral therapy.: Here, we compared the HCV genotyping performance of the cobas HCV GT assay against the Versant HCV Genotype 2.0 (LiPA) assay, using 97 archived serum samples.: In the event of discrepant or indeterminate results produced by either assay, the core and NS5B regions were sequenced.: Of t ...
DOI:
10.1016/j.jviromet.2018.02.004

19. Complex patterns of Hepatitis-C virus longitudinal clustering in a high-risk population

Author:
Rose, Rebecca; Lamers, Susanna L.; Massaccesi, Guido; Osburn, William; Ray, Stuart C.; Thomas, David L.; Cox, Andrea L.; Laeyendecker, Oliver
Source:
Infection, genetics, and evolution 2018 v.58 pp. 77-82
ISSN:
1567-1348
Subject:
Hepatitis C virus,   etc   ; drug abuse; drugs; genetic distance; people; phylogeny; viruses;     Show all 7 Subjects
Abstract:
... We investigated longitudinal viral clustering among and within subjects in a highly networked cohort of people who inject drugs (PWID). All subjects had estimated dates of infection and two or more E1 sequences (bp 943–1288 relative to H77) with 1 to 14years of follow up. Two methods (HIV-TRACE and PhyloPart) were used to determine clusters. Genetic distance thresholds were determined by comparing ...
DOI:
10.1016/j.meegid.2017.12.015

20. Protein backbone flexibility pattern is evolutionarily conserved in the Flaviviridae family: A case of NS3 protease in Flavivirus and Hepacivirus

Author:
Palanisamy, Navaneethan; Akaberi, Dario; Lennerstrand, Johan
Source:
Molecular phylogenetics and evolution 2018 v.118 pp. 58-63
ISSN:
1055-7903
Subject:
Hepatitis C virus,   etc   ; Flavivirus; birds; crystal structure; drugs; humans; protein structure; proteinases; proteins; sequence homology; viruses;     Show all 11 Subjects
Abstract:
... Viruses belonging to the Flaviviridae family have been an important health concern for humans, animals and birds alike. No specific treatment is available yet for many of the viral infections caused by the members of this family. Lack of specific drugs against these viruses is mainly due to lack of protein structure information. It has been known that protein backbone fluctuation pattern is highly ...
DOI:
10.1016/j.ympev.2017.09.015