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1241. Rabies virus matrix protein interplay with eIF3, new insights into rabies virus pathogenesis

Author:
Komarova, Anastassia V.; Real, Eléonore; Borman, Andrew M.; Brocard, Michèle; England, Patrick; Tordo, Noël; Hershey, John W.B.; Kean, Katherine M.; Jacob, Yves
Source:
Nucleic acids research 2007 v.35 no.5 pp. 1522-1532
ISSN:
0305-1048
Subject:
Hepatitis C virus,   etc   ; translation (genetics); Rabies lyssavirus; protein subunits; cell culture; genome; two hybrid system techniques; transcription (genetics); gene expression; precipitin tests; ribosomal proteins; viral proteins; mammals; pathogenesis; virus assembly; surface plasmon resonance; gene expression regulation; protein-protein interactions; 5' untranslated regions;     Show all 19 Subjects
Abstract:
... Viral proteins are frequently multifunctional to accommodate the high density of information encoded in viral genomes. Matrix (M) protein of negative-stranded RNA viruses such as Rhabdoviridae is one such example. Its primary function is virus assembly/budding but it is also involved in the switch from viral transcription to replication and the concomitant down regulation of host gene expression. ...
DOI:
10.1093/nar/gkl1127
PubMed:
17287294
PubMed Central:
PMC1865048

1242. Pilot Clinical Trial of the Use of Alpha-tocopherol for the Prevention of Hepatocellular Carcinoma in Patients with Liver Cirrhosis

Author:
Takagi, H.; Kakizaki, S.; Sohara, N.; Sato, K.; Tsukioka, G.; Tago, Y.; Konaka, K.; Kabeya, K.; Kaneko, M.; Takayama, H.; Hashimoto, Y.; Yamada, T.; Takahashi, H.; Shimojo, H.; Nagamine, T.; Mori, M.
Source:
International journal for vitamin and nutrition research 2003 v.73 no.6 pp. 411-415
ISSN:
0300-9831
Subject:
Hepatitis C virus,   etc   ; alanine transaminase; alpha-tocopherol; blood platelet count; blood serum; chemoprevention; cholesterol; chronic hepatitis C; clinical trials; gender; hepatoma; liver cirrhosis; liver function; patients; serum albumin; survival rate;     Show all 16 Subjects
Abstract:
... Patients with chronic hepatitis C virus (HCV) infection often develop liver cirrhosis and hepatocellular carcinoma (HCC). The purpose of this study was to test the chemopreventive effect of alpha-tocopherol on hepatocarcinogenesis in patients with liver cirrhosis and a history of HCV infection. Eighty-three patients with liver cirrhosis and with positive history of HCV infection were divided at ra ...
DOI:
10.1024/0300-9831.73.6.411

1243. Biochemical properties of a minimal functional domain with ATP‐binding activity of the NTPase/helicase of hepatitis C virus

Author:
Borowski, Peter; Kuehl, Reinhard; Mueller, Oliver; Hwang, Lih‐Hwa; Schulze zur Wiesch, Julian; Schmitz, Herbert
Source:
European journal of biochemistry 1999 v.266 no.3 pp. 715-723
ISSN:
0014-2956
Subject:
Hepatitis C virus,   etc   ; adenosine triphosphate; amino acids; binding sites; inhibitory concentration 50; ions; liquid chromatography; magnesium; manganese; nucleoside-triphosphate phosphatase; paclitaxel; polynucleotides; proteolysis; trifluoperazine;     Show all 14 Subjects
Abstract:
... The RNA‐stimulated nucleoside triphosphatase (NTPase) and helicase of hepatitis C virus (HCV) consists of three domains with highly conserved NTP binding motifs located in the first domain. The ATP‐binding domain was obtained by limited proteolysis of a greater fragment of the HCV polyprotein, and it was purified to homogenity by column chromatography. The identity of the domain, comprising amino ...
DOI:
10.1046/j.1432-1327.1999.00854.x

1244. Liver and peripheral blood mononuclear cells are not major sites for GB virus-C/hepatitis G virus replication

Author:
Kao, J.-H.; Chen, W.; Chen, P.-J.; Lai, M.-Y.; Chen, D.-S.
Source:
Archives of virology 1999 v.144 no.11 pp. 2173-2183
ISSN:
0304-8608
Subject:
Hepatitis C virus,   etc   ; RNA; humans; liver; mononuclear leukocytes; nucleotide sequences; pathogenesis; patients; reverse transcriptase polymerase chain reaction; viral load; virus replication; viruses;     Show all 12 Subjects
Abstract:
... The pathogenesis and replication sites of GB virus-C/hepatitis G virus (GBV-C/HGV) in humans remain unclear. The presence of GBV-C/HGV and hepatitis C virus (HCV) RNA sequences in matched serum, peripheral blood mononuclear cells (PBMC) and liver samples in 10 patients with GBV-C/HGV infection, 8 of whom were coinfected with HCV was explored. Positive- and negative-strand GBV-C/HGV and HCV RNA wer ...
DOI:
10.1007/s007050050631
PubMed:
10603171

1245. Follow-up of hepatitis C virus RNA in peripheral blood mononuclear cells during interferon therapy

Author:
Cribier, B.; Uhl, G.; Schmitt, C.; Doffoël, M.; Vetter, D.; Kirn, A.; Stoll-Keller, F.
Source:
Archives of virology 1999 v.144 no.2 pp. 355-364
ISSN:
0304-8608
Subject:
Hepatitis C virus,   etc   ; DNA; RNA; adsorption; interferons; mononuclear leukocytes; patients; polymerase chain reaction; relapse; reverse transcription; ribonucleases; therapeutics; trypsin; viremia; viruses;     Show all 15 Subjects
Abstract:
... Mononuclear cells can be infected in vitro by hepatitis C virus and the viral RNA can be detected in mononuclear cells of chronically infected patients. It was suggested that the virus could persist in the mononuclear cells of some patients treated by interferon. The aim of this study was to follow the presence of viral RNA in the plasma and peripheral blood mononuclear cells of 16 chronically inf ...
DOI:
10.1007/s007050050509
PubMed:
10470259

1246. Molecular cloning of an Australian isolate of hepatitis C virus

Author:
Trowbridge, R.; Gowans, E. J.
Source:
Archives of virology 1998 v.143 no.3 pp. 501-511
ISSN:
0304-8608
Subject:
Hepatitis C virus,   etc   ; amino acid sequences; amino acids; clones; complementary DNA; genome; genotype; hepatitis C; molecular cloning; nucleotides; open reading frames; sequence analysis;     Show all 12 Subjects
Abstract:
... The genomic sequence of an Australian isolate of hepatitis C virus (HCV) was determined from overlapping cDNA clones obtained from a small amount (1.2 ml) of serum from a single individual with hepatitis C. The isolate (HCV-A) comprises 9 379 nucleotides (nt) including 324 nt of a 5′ untranslated region (5′UTR), a single long open reading frame of 9 033 nt encoding a polyprotein of 3 010 amino aci ...
DOI:
10.1007/s007050050306
PubMed:
9572551

1247. GB virus C/hepatitis G virus (GBV-C/HGV) infectionin Chiang Mai, Thailand, and identification of variants on the basis of 5′-untranslated region sequences

Author:
Katayama, Y.; Apichartpiyakul, C.; Handajani, R.; Ishido, S.; Hotta, H.
Source:
Archives of virology 1997 v.142 no.12 pp. 2433-2445
ISSN:
0304-8608
Subject:
Hepatitis C virus,   etc   ; RNA; antibodies; chronic hepatitis; drugs; genome; hepatoma; liver; liver cirrhosis; patients; phylogeny; reverse transcriptase polymerase chain reaction; viruses; Europe; Thailand; United States;     Show all 16 Subjects
Abstract:
... By using reverse transcription and PCR for NS3 and 5′-untranslated regions (5′UTR) of the viral genome, prevalence of GB virus C/hepatitis G virus (GBV-C/HGV) infection in Chiang Mai, Thailand, was studied. High prevalence of GBV-C/HGV infection was observed among intravenous drug users (32%) and hemodialyzed patients (25%). The prevalence was also considerably high among patients with chronic liv ...
DOI:
10.1007/s007050050253
PubMed:
9672605

1248. Hepatitis C virus infection in mixed cryoglobulinemia and B-cell non-Hodgkin’s lymphoma: evidence for a pathogenetic role

Author:
Zignego, A. L.; Ferri, C.; Giannini, C.; La Civita, L.; Careccia, G.; Longombardo, G.; Bellesi, G.; Caracciolo, F.; Thiers, V.; Gentilini, P.
Source:
Archives of virology 1997 v.142 no.3 pp. 545-555
ISSN:
0304-8608
Subject:
Hepatitis C virus,   etc   ; B-DNA; RNA; antigen-antibody complex; autoimmune diseases; evolution; genotype; genotyping; hybridization; lymphoma; mixed infection; mononuclear leukocytes; nucleotide sequences; pathogenesis; patients; polymerase chain reaction; vasculitis;     Show all 17 Subjects
Abstract:
... We investigated the pathogenetic relevance of hepatitis C virus (HCV) infection in mixed cryoglobulinemia (MC) with or without complicating B-cell Non-Hodgkin’s lymphoma (NHL) in comparison with other immunological and lymphoproliferative disorders. The following groups of patients were studied: A) 25 patients with MC in 7 cases evolved into B-cell NHL; B) 25 healthy subjects; C) 22 patients with ...
DOI:
10.1007/s007050050100
PubMed:
9349300

1249. Quantitative analysis of hepatitis C virus activity in vivo in different groups of untreated patients

Author:
Manzin, A.; Solforosi, L.; Giostra, F.; Bianchi, F. B.; Bruno, S.; Rossi, S.; Gabrielli, A.; Candela, M.; Petrelli, E.; Clementi, M.
Source:
Archives of virology 1997 v.142 no.3 pp. 465-472
ISSN:
0304-8608
Subject:
Hepatitis C virus,   etc   ; DNA; RNA; alanine transaminase; antibodies; chronic hepatitis; liver; pathogenesis; patients; quantitative analysis; reverse transcriptase polymerase chain reaction; viral load; viremia;     Show all 13 Subjects
Abstract:
... Highly sensitive competitive PCR (cPCR) and competitive reverse transcription PCR (cRT-PCR) methodologies were recently developed and applied for quantifying viral DNA and RNA species (including HCV RNA) present in clinical samples at low concentration. In this study, we used cRT-PCR to compare the viral load of 118 untreated patients with HCV infection and different clinical conditions (80 patien ...
DOI:
10.1007/s007050050093
PubMed:
9349293

1250. Development and Characterisation of Recombinant Hepatitis Delta Virus-like Particles

Author:
Ward, Scott Matthew; Macnaughton, Thomas Bernard; Gowans, Eric James
Source:
Virus genes 2001 v.23 no.1 pp. 97-104
ISSN:
0920-8569
Subject:
Hepatitis C virus,   etc   ; B-lymphocytes; Hepatitis B virus; Papillomaviridae; T-lymphocytes; amino acids; antibodies; cell culture; cytotoxicity; epitopes; hepatitis B antigens; humans; mice; polyproteins; recombinant fusion proteins; secretion; sucrose; surface antigens; transfection; virus-like particles;     Show all 20 Subjects
Abstract:
... Injection of particulate hepatitis B virus surface antigen (HBsAg) in mice leads to the induction of a HBsAg-specific class-I-restricted cytotoxic T lymphocyte (CTL) response. It is proposed that any protein internal to HBsAg will also be able to elicit a specific CTL response. In this study, several carboxy-terminal truncations of hepatitis C virus (HCV) core protein were fused to varying lengths ...
DOI:
10.1023/A:1011195715747

1251. Identification and Molecular Characterisation of the Complete Genome of a Singapore Isolate of Hepatitis C Virus: Sequence Comparison with other Strains and Phylogenetic Analysis

Author:
Lim, Siew Pheng; Khu, Yee Ling; Hong, Wan Jin; Tay, Alice; Ting, Anthony Eugene; Lim, Seng Gee; Tan, Yin Hwee
Source:
Virus genes 2001 v.23 no.1 pp. 89-95
ISSN:
0920-8569
Subject:
Hepatitis C virus,   etc   ; amino acids; blood serum; clones; complementary DNA; genome; genotype; hepatitis C; nucleotides; open reading frames; phylogeny; reverse transcriptase polymerase chain reaction; sequence analysis; transcription (genetics); Singapore; Taiwan;     Show all 16 Subjects
Abstract:
... The complete genomic sequence of a Singapore isolate of the hepatitis C virus (HCV) was obtained from serum of an individual chronically infected with HCV. Nine overlapping cDNA clones covering the entire viral genome was amplified by reverse-transcription–polymerase chain reaction (RT–PCR). This isolate (HCV-S1) comprised 9,609 nucleotides (nt), including 341 nt of the complete 5′ untranslated re ...
DOI:
10.1023/A:1011143731677

1252. Experimental evidence against replication or dissemination of hepatitis C virus in mosquitoes (Diptera: Culicidae) using detection by reverse transcriptase polymerase chain reaction

Author:
Silverman, A.L.; McCray, D.G.; Gordon, S.C.; Morgan, W.T.; Walker, E.D.
Source:
Journal of medical entomology 1996 v.33 no.3 pp. 398-401
ISSN:
0022-2585
Subject:
Hepatitis C virus,   etc   ; Aedes aegypti; Aedes albopictus; Anopheles stephensi; virus replication; infection; head; abdomen; thorax; detection; RNA-directed DNA polymerase; polymerase chain reaction;     Show all 12 Subjects
Abstract:
... In 3 laboratory experiments, mosquitoes were fed hepatitis C virus (HCV)-RNA positive blood by using membrane feeders, separated into head, thorax, and abdomen, and tested by a reverse transcriptase polymerase chain reaction for HCV-RNA. HCV did not replicate or disseminate in mosquitoes that had ingested blood from patients that were HCV-viremic positive. When yellow fever mosquitoes, Aedes aegyp ...
DOI:
10.1093/jmedent/33.3.398
PubMed:
8667387

1253. A common structural core in the internal ribosome entry sites of picornavirus, hepatitis C virus, and pestivirus

Author:
Le, S.Y.; Siddiqui, A.; Maizel, J.V. Jr.
Source:
Virus genes 1996 v.12 no.2 pp. 135-147
ISSN:
0920-8569
Subject:
Hepatitis C virus,   etc   ; Monte Carlo method; protein secondary structure; Classical swine fever virus; phylogeny; ribosomes; Aphthovirus; Bovine viral diarrhea virus 1; nucleotide sequences; RNA; molecular conformation;     Show all 11 Subjects
DOI:
10.1007/BF00572952
PubMed:
8879130

1254. Diet and hepatocellular carcinoma: a case-control study in Greece

Author:
Kuper, H.; Tzonou, A.; Lagiou, P.; Mucci, L.A.; Trichopoulos, D.; Stuver, S.O.; Trichopoulou, A.
Source:
Nutrition and cancer 2000 v.38 no.1 pp. 6-12
ISSN:
0163-5581
Subject:
Hepatitis C virus,   etc   ; hepatocytes; Hepatitis B virus; food intake; nutrient intake; energy intake; men; women; food groups; carcinoma; liver neoplasms; alcoholic beverages; smoking (habit); age; risk factors; patients; dietary surveys; education; Greece;     Show all 19 Subjects
Abstract:
... We conducted a case-control study in Athens, Greece, to investigate the role of diet in the etiology of hepatocellular carcinoma (HCC). Subjects were 97 incident cases of HCC and 128 controls with no history of cancer admitted for minor ailments in three major hospitals. Information on diet was collected using a validated food frequency questionnaire, and infection with hepatitis virus B (HBV) or ...
DOI:
10.1207/S15327914NC381_2
PubMed:
11341045

1255. Impaired response to alpha interferon in patients with an inapparent hepatitis B and hepatitis C virus coinfection

Author:
Zignego, A. L.; Fontana, R.; Puliti, S.; Barbagli, S.; Monti, M.; Careccia, G.; Giannelli, F.; Giannini, C.; Buzzelli, G.; Brunetto, M. R.; Bonino, F.; Gentilini, P.
Source:
Archives of virology 1997 v.142 no.3 pp. 535-544
ISSN:
0304-8608
Subject:
Hepatitis C virus,   etc   ; DNA; DNA primers; Hepatitis A virus; Hepatitis B virus; RNA; alanine transaminase; antibodies; chronic hepatitis; genome; hepatitis B; immunoglobulin M; interferons; liver; mixed infection; patients; polymerase chain reaction; relapse; therapeutics;     Show all 19 Subjects
Abstract:
... The possibility of hepatitis B virus (HBV) infection in HBsAg-negative patients has been shown. However, an “inapparent” coinfection by HBV in hepatitis C virus (HCV)-positive patients generally is not taken into account in clinical practice. Mechanisms responsible for resistance to interferon (IFN) have not been completely clarified. The aim of this study was to investigate whether an “inapparent ...
DOI:
10.1007/s007050050099
PubMed:
9349299