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You searched for: Subject term Japan Remove constraint Subject term: Japan Subject term excretion Remove constraint Subject term: excretion Text availability Citation in PubAg Remove constraint Text availability: Citation in PubAg
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1. Physiological phases of nymphal molting defined by mobility, body weight decrease, and excretion in Haemaphysalis longicornis (Acari: Ixodidae)

Author:
Koh, K.; Shiraishi, S.; Uchida, T.A.
Source:
Journal of medical entomology 1989 v.26 no.1 pp. 77-80
ISSN:
0022-2585
Subject:
sexual development; Haemaphysalis longicornis; insect pests; ticks; body weight; guanine; nymphs; molting; excretion; Japan
DOI:
10.1093/jmedent/26.1.77
PubMed:
2926778

2. Characteristics of butyltin accumulation and its biomagnification in Steller sea lion (Eumetopias jubatus)

Author:
Kim, G.B.; Tanabe, S.; Tatsukawa, R.; Loughlin, T.R.; Shimazaki, K.
Source:
Environmental toxicology and chemistry 1996 v.15 no.11 pp. 2043-2048
ISSN:
0730-7268
Subject:
Eumetopias jubatus; animals; bioaccumulation; coastal water; dibutyltin; diet; excretion; liver; tributyltin; Alaska; Japan
Abstract:
... The present study was conducted to examine sex difference, age, and temporal trends of butyltin accumulation and its biomagnification in Steller sea lion (Eumetopias jubatus) collected from Alaska, USA, during 1976-1985 and from Hokkaido, Japan, during 1994-1995. Average concentration of total butyltin compounds (Epsilon BT) in the liver of Steller sea lion from Alaska (19 ng/g wet weight) was muc ...
DOI:
10.1897/1551-5028(1996)015<2043:COBAAI>2.3.CO;2

3. Distribution, biomagnification, and elimination of butyltin compound residues in common cormorants (Phalacrocorax carbo) from Lake Biwa, Japan

Author:
Guruge, K.S.; Tanabe, S.; Iwata, H.; Taksukawa, R.; Yamagishi, S.
Source:
Archives of environmental contamination and toxicology 1996 v.31 no.2 pp. 210-217
ISSN:
0090-4341
Subject:
water pollution; liver; Phalacrocorax carbo; spatial distribution; organotin compounds; excretion; tissue distribution; pollutants; wild birds; fish; kidneys; feathers; animal tissues; Japan
DOI:
10.1007/BF00212368
PubMed:
8781071

4. Estimation of salt intake by a simple questionnaire

Author:
Nakatsuka, H.; Satoh, H.; Watanabe, T.; Imai, Y.; Abe, K.; Ikeda, M.
Source:
Ecology of food and nutrition 1996 v.35 no.1 pp. 15-23
ISSN:
0367-0244
Subject:
nutrient intake; questionnaires; eating habits; urine; men; women; sodium chloride; dietary surveys; excretion; Japan
Abstract:
... To assess whether a simple questionnaire could be used to categorize the subjects into different salt-intake groups, we compared the answers to four questions concerning food habits (total amount of food, number of bowls of miso soup, amount of pickles and saltiness of home-made pickles) with 24-hr urine NaCl levels of 1025 subjects from a Japanese farming village. The correlation coefficients bet ...
DOI:
10.1080/03670244.1996.9991472

5. Energy value of mixed glycosidic linked dextrin determined in rats

Author:
Tsuji, K.; Gordon, D.T.
Source:
Journal of agricultural and food chemistry 1998 v.46 no.6 pp. 2253-2259
ISSN:
0021-8561
Subject:
dietary fiber; in vitro digestibility; corn starch; GRAS substances; bulking agents; maltodextrins; blood glucose; liveweight gain; intestinal absorption; rats; metabolizable energy; excretion; United States; Japan
Abstract:
... A series of in vivo and in vitro experiments was conducted to determine the available energy of a bulking agent, Fibersol 2 (FS-2). Fibersol 2 is obtained by a combination of heat and enzyme treatments of cornstarch to produce a low-viscosity, low-digestible dextrin with an average molecular massweight of 2000 Da. Although the substance is of the type known in Japan as an indigestible dextrin, it ...
DOI:
10.1021/jf9708453

6. Abnormality in urinary protein excretion in Japanese men with impaired glucose tolerance

Author:
Fujita, H.; Narita, T.; Ito, S.
Source:
Diabetes care 1999 v.22 no.5 pp. 823-826
ISSN:
0149-5992
Subject:
protein metabolism; excretion; urine; men; glucose tolerance; Japan
DOI:
10.2337/diacare.22.5.823
PubMed:
10332689

7. Urinary sodium/potassium ratio and prevalence of hypertension in two communities of different historical origin in Ohshima Island, Nagasaki, Japan

Author:
Yoshida, M.; Koyama, H.; Aoyagi, K.; Moji, K.; Takemoto, T.I.
Source:
Ecology of food and nutrition 2000 v.39 no.3 pp. 183-198
ISSN:
0367-0244
Subject:
tofu; food intake; urine; disease prevalence; meat; hypertension; sodium; potassium; fish; community health; natto; population; excretion; Japan
DOI:
10.1080/03670244.2000.9991614

8. Flexibility in the composition and concentration of amino acids in honeydew of the drepanosiphid aphid Tuberculatus quercicola

Author:
Yao, I.; Akimoto, S.
Source:
Ecological entomology 2002 v.27 no.6 pp. 745-752
ISSN:
0307-6946
Subject:
Aphididae; honeydew; free amino acids; excretion; mutualism; host plants; Quercus dentata; phloem; sap; nutrient availability; seasonal variation; Japan
Abstract:
... 1. Mutualistic interactions between aphids and ants are mediated by honeydew that aphids produce. Previous work showed that when attended by the ant Formica yessensis Forel (Hymenoptera: Formicidae), nymphs of the aphid Tuberculatus quercicola (Matsumura) (Homoptera: Aphididae) developed into significantly smaller adults with lower fecundity than did nymphs that were not ant attended. 2. This stud ...
DOI:
10.1046/j.1365-2311.2002.00455.x

9. Soybean Isoflavones Reduce Postmenopausal Bone Resorption in Female Japanese Immigrants in Brazil: A Ten-Week Study

Author:
Yamori, Yukio; Moriguchi, Emilio H.; Teramoto, Takanori; Miura, Ayako; Fukui, Yutaka; Honda, Kei-ich; Fukui, Masakazu; Nara, Yasuo; Taira, Kazuhiko; Moriguchi, Yukio
Source:
Journal of the American College of Nutrition 2002 v.21 no.6 pp. 560-563
ISSN:
0731-5724
Subject:
animal models; bone resorption; excretion; food intake; humans; immigration; isoflavones; osteoporosis; postmenopause; soybeans; urine; women; Brazil
Abstract:
... Objective: Some human studies and animal models of experimental osteoporosis have shown that soy isoflavones may be effective on bone health. In this study, we carried out an intervention study to explore the effects of dietary isoflavone on bone metabolism. Methods: Forty healthy female postmenopausal Japanese immigrants living in Brazil were divided into two groups: isoflavone-administered (n = ...
DOI:
10.1080/07315724.2002.10719255
PubMed:
12480802

10. Comparison of digestibility and breath hydrogen gas excretion of fructo-oligosaccharide, galactosyl-sucrose, and isomalto-oligosaccharide in healthy human subjects

Author:
Oku, T.; Nakamura, S.
Source:
European journal of clinical nutrition 2003 v.57 no.9 pp. 1150-1156
ISSN:
0954-3007
Subject:
breath tests; digestibility; enzymes; excretion; females; fructooligosaccharides; humans; hydrogen; ingestion; large intestine; males; nutrition; public health; small intestine; Japan
Abstract:
... Objectives: To clarify the difference of digestibility in the small intestine among fructo-oligosaccharide (FOS), galactosyl-sucrose (GS), and isomalto-oligosaccharide (IMO) using breath hydrogen test. Design: The first step: screening test of breath hydrogen excretion and FOS tolerance test to select the subjects. The second step: breath hydrogen test of three kinds of oligosaccharides, carried o ...
DOI:
10.1038/sj.ejcn.1601666

11. Contribution of livestock excreta to nutrient balances

Author:
Sheldrick, William; Syers, J. Keith; Lingard, John
Source:
Nutrient cycling in agroecosystems 2003 v.66 no.2 pp. 119-131
ISSN:
1385-1314
Subject:
Food and Agriculture Organization; Internet; cattle; databases; developed countries; developing countries; excreta; excretion; fertilizers; livestock and meat industry; livestock production; models; nutrients; poultry; soil; swine; time series analysis; Japan; Kenya; Netherlands
Abstract:
... Livestock excreta make an important contribution to soil nutrient inputs and in many developing countries are the only significant input. However, there is little quantitative information available on excreta, manure production, and application and this makes it difficult to obtain meaningful soil nutrient balances. A model has therefore been developed to calculate the excreta produced and manure ...
DOI:
10.1023/A:1023944131188

12. Development, Progression, and Regression of Microalbuminuria in Japanese Patients With Type 2 Diabetes Under Tight Glycemic and Blood Pressure Control: The Kashiwa Study

Author:
Yamada, Takashi; Komatsu, Mitsuhisa; Komiya, Ichiro; Miyahara, Yasuhiro; Shima, Yukino; Matsuzaki, Mitsuko; Ishikawa, Yuka; Mita, Reiko; Fujiwara, Mika; Furusato, Nobuko; Nishi, Kazue; Aizawa, Toru
Source:
Diabetes care 2005 v.28 no.11 pp. 2733-2738
ISSN:
0149-5992
Subject:
albumins; blood glucose; correlation; creatinine; excretion; glycemic control; kidney diseases; men; noninsulin-dependent diabetes mellitus; patients; prediction; systolic blood pressure; women
Abstract:
... OBJECTIVE:-- The goal of this study was to know the fate of albuminuria in Japanese patients with type 2 diabetes under tight blood pressure and glycemic control. RESEARCH DESIGN AND METHODS-- Patients having normoalbuminuria (urinary albumin excretion <30 mg/g creatinine, n = 179) or microalbuminuria (albumin excretion 30-299 mg/g creatinine, n = 94) at baseline have been followed up for 8 years: ...
DOI:
10.2337/diacare.28.11.2733
PubMed:
16249548

13. Serum Interleukin-18 Levels Are Associated With Nephropathy and Atherosclerosis in Japanese Patients With Type 2 Diabetes

Author:
Nakamura, Akihiko; Shikata, Kenichi; Hiramatsu, Makoto; Nakatou, Tatsuaki; Kitamura, Takuya; Wada, Jun; Itoshima, Tatsuya; Makino, Hirofumi
Source:
Diabetes care 2005 v.28 no.12 pp. 2890-2895
ISSN:
0149-5992
Subject:
C-reactive protein; albumins; atherosclerosis; blood serum; correlation; creatinine; death; diabetic nephropathy; excretion; interleukin-18; interleukin-6; linear models; noninsulin-dependent diabetes mellitus; pathogenesis; patients; regression analysis
Abstract:
... OBJECTIVE:--Interleukin (IL)-18 is a proinflammatory cytokine secreted from mononuclear cells. Serum concentration of IL-18 is a strong predictor of death in patients with cardiovascular diseases. Recent studies have shown that microinflammation is involved in the pathogenesis of diabetic nephropathy as well as of cardiovascular diseases. This study aimed to test the hypothesis that the serum leve ...
DOI:
10.2337/diacare.28.12.2890
PubMed:
16306550

14. Biodilution of heavy metals in a stream macroinvertebrate food web: Evidence from stable isotope analysis

Author:
Kozo Watanabe; Michael T. Monaghan; Yasuhiro Takemon; Tatsuo Omura
Source:
Science of the total environment 2008 v.394 no.1 pp. 57-67
ISSN:
0048-9697
Subject:
Epilithon; carbon; community structure; correlation; excretion; food webs; heavy metals; macroinvertebrates; models; nitrogen; stable isotopes; streams; vegetation; Japan
Abstract:
... Analysis of carbon (δ¹³C) and nitrogen (δ¹⁵N) stable isotopes provides an increasingly important means of understanding the complex trophic structure of macroinvertebrate communities in streams. We coupled a stable isotope approach with a contaminant analysis of six metals (Pb, Ag, Zn, Hg, Cu, As) to trace the accumulation and dilution of metals from an abandoned mine across trophic levels of the ...
DOI:
10.1016/j.scitotenv.2008.01.006
PubMed:
18280545

15. Dietary and lifestyle correlates of urinary excretion status of equol in Japanese women

Author:
Nagata, C.; Ueno, T.; Uchiyama, S.; Nagao, Y.; Yamamoto, S.; Shibuya, C.; Kashiki, Y.; Shimizu, H.
Source:
Nutrition and cancer 2008 v.60 no.1 pp. 49-54
ISSN:
0163-5581
Subject:
urine; women; health status; metabolites; food frequency questionnaires; daidzein; lifestyle; dairy products; dietary surveys; excretion; Japan
DOI:
10.1080/01635580701525885
PubMed:
18444135

16. Serial Follow-Up Study on Renal Handling of Calcium and Phosphorus After Soil Replacement in Cd-Polluted Rice Paddies Estimated Using a General Linear Mixed Model

Author:
Etsuko Kobayashi; Yasushi Suwazono; Ryumon Honda; Mire Dochi; Muneko Nishijo; Teruhiko Kido; Hideaki Nakagawa
Source:
Biological trace element research 2009 v.129 no.1-3 pp. 261-269
ISSN:
0163-4984
Subject:
blood serum; calcium; excretion; men; normal values; paddies; phosphorus; rice soils; statistical models; urine; watersheds; women; Japan
Abstract:
... A 10-year follow-up study was conducted to investigate the effects of renal handling of calcium (Ca) and phosphorus (P) after the removal of cadmium-polluted soil in rice paddies and replacing it with nonpolluted soil. Using a general linear mixed model, serial changes of Ca and P concentrations in urine and serum (Ca-U/S, P-U/S), fractional excretion of Ca (FECa), and percent tubular reabsorption ...
DOI:
10.1007/s12011-008-8286-5
PubMed:
19089319

17. Urinary excretion of vitamin B₁, B₂, B₆, niacin, pantothenic acid, folate, and vitamin C correlates with dietary intakes of free-living elderly, female Japanese

Author:
Tsuji, Tomiko; Fukuwatari, Tsutomu; Sasaki, Satoshi; Shibata, Katsumi
Source:
Nutrition research 2010 v.30 no.3 pp. 171-178
ISSN:
0271-5317
Subject:
food intake; elderly; Japanese people; urine; women; riboflavin; pyridoxine; elderly nutrition; folic acid; niacin; pantothenic acid; thiamin; excretion; ascorbic acid; Japan
Abstract:
... We hypothesized that 24-hour urinary excretion of water-soluble vitamins might correlate with their intake in free-living Japanese elderly females aged 70 to 84 years. We performed a cross-sectional study composed of 37 healthy, elderly, Japanese females living freely. All foods and the corresponding weights consumed for 4 consecutive days were recorded accurately. A 24-hour urine sample was colle ...
DOI:
10.1016/j.nutres.2010.02.001

18. Adequacy of vitamin C supplementation in patients with gastrointestinal disorders receiving parenteral nutrition: A randomized trial

Author:
Hiroshi Kuwabara; Narihide Goseki; Hiroshi Nakamura; Satoru Tamai; Hiroyuki Baba; Kazumi Nakajima
Source:
e-SPEN, the European e-journal of clinical nutrition and metabolism 2011 v.6 no.3 pp. e148
ISSN:
1751-4991
Subject:
adults; ascorbic acid; blood; digestive system diseases; excretion; inflammation; intravenous injection; oxidative stress; parenteral feeding; patients; urine; vitamin status; Japan
Abstract:
... BACKGROUND & AIMS: In Japan, supplemental vitamins are not always included during short-term peripheral parenteral nutrition (PPN) therapy. In addition, a dose of 100 mg/day of vitamin C shown in the 1975 AMA guideline for adult intravenous multi-vitamin formation, is inadequate to keep vitamin C levels in the normal range. We investigated the adequacy of 500 mg of supplemental vitamin C in patien ...
DOI:
10.1016/j.eclnm.2011.01.009

19. Differences in the production and excretion kinetics of okadaic acid, dinophysistoxin‐1, and pectenotoxin‐2 between cultures of dinophysis acuminata and dinophysis fortii isolated from western japan1

Author:
Satoshi Nagai; Toshiyuki Suzuki; Tetsuya Nishikawa; Takashi Kamiyama
Source:
Journal of phycology 2011 v.47 no.6 pp. 1326-1337
ISSN:
0022-3646
Subject:
Dinophysis acuminata; Dinophysis fortii; excretion; okadaic acid; toxicity; Japan
Abstract:
... We established clonal cultures of Dinophysis acuminata Clap. et Lachm. and D. fortii Pavill. isolated from western Japan and examined toxin production in them, focusing on intracellular production and extracellular excretion. At the end of incubations, the total amounts of pectenotoxin‐2 (PTX‐2), dinophysistoxin‐1 (DTX‐1), and okadaic acid (OA) in the D. acuminata cultures reached up to 67 ...
DOI:
10.1111/j.1529-8817.2011.01076.x

20. Changes of Mercury Contamination in Red-Crowned Cranes, Grus japonensis, in East Hokkaido, Japan

Author:
Hiroki Teraoka; Yukari Tagami; Moe Kudo; Yoshiaki Miura; Erika Okamoto; Fumio Matsumoto; Kimiya Koga; Akiko Uebayashi; Ryoji Shimura; Masako Inoue; Kunikazu Momose; Hiroyuki Masatomi; Takio Kitazawa; Takeo Hiraga; Annamalai Subramanian
Source:
Archives of environmental contamination and toxicology 2012 v.63 no.1 pp. 153-160
ISSN:
0090-4341
Subject:
Grus; birds; blood; excretion; feathers; flight; habitats; indicator species; islands; kidneys; liver; mercury; pollution; watersheds; Japan
Abstract:
... Red-crowned cranes (Grus japonensis) are native to eastern Hokkaido (island population), in contrast to the mainland, which migrates between the Amur River basin and eastern China–Korea peninsula. During the 1990s we found that Red-crowned cranes in Hokkaido were highly contaminated with mercury: however, the source was unknown. We investigated the time trend of mercury contamination in Red-crowne ...
DOI:
10.1007/s00244-011-9742-3
PubMed:
22193864

21. Genetics and infectivity of H5N1 highly pathogenic avian influenza viruses isolated from chickens and wild birds in Japan during 2010–11

Author:
Yuko Uchida; Yasushi Suzuki; Masayuki Shirakura; Akira Kawaguchi; Eri Nobusawa; Taichiro Tanikawa; Hirokazu Hikono; Nobuhiro Takemae; Masaji Mase; Katsushi Kanehira; Tsuyoshi Hayashi; Yuichi Tagawa; Masato Tashiro; Takehiko Saito
Source:
Virus research 2012 v.170 no.1-2 pp. 109-117
ISSN:
0168-1702
Subject:
Influenza A virus; ancestry; chickens; ducks; excretion; genes; genetic techniques and protocols; mandarins; pathogenicity; viruses; wild birds; Japan
Abstract:
... Outbreaks of H5N1 subtype highly pathogenic avian influenza virus (HPAIV) were recorded in chickens, domesticated birds and wild birds throughout Japan from November 2010 to March 2011. Genetic analysis of the Japanese isolates indicated that all gene segments, except the PA gene, were closely related to Japanese wild bird isolates in 2008 and belonged to clade 2.3.2.1 classified by the WHO/OIE/FA ...
DOI:
10.1016/j.virusres.2012.09.004

22. Oryeongsan (Wulingsan), a traditional Chinese herbal medicine, induces natriuresis and diuresis along with an inhibition of the renin–angiotensin–aldosterone system in rats

Author:
You Mee Ahn; Kyung Woo Cho; Dae Gill Kang; Ho Sub Lee
Source:
Journal of ethnopharmacology 2012 v.141 no.3 pp. 780-785
ISSN:
0378-8741
Subject:
aldosterone; body fluids; diuresis; excretion; glomerular filtration rate; herbal medicines; homeostasis; osmolality; rats; renin; China; Japan; Korean Peninsula
Abstract:
... ETHNOPHARMACOLOGICAL RELEVANCE: Oryeongsan (ORS, Wulingsan), a formula composed of five herbal medicines, has long been used for the treatment of impairments of the regulation of body fluid homeostasis in China, Japan and Korea. AIM OF THE STUDY: The purpose of the present study was to test the effects of ORS on the renal function and the mechanisms involved in rats. MATERIALS AND METHODS: Experim ...
DOI:
10.1016/j.jep.2012.02.021
PubMed:
22366680

23. The degree of misreporting of the energy-adjusted intake of protein, potassium, and sodium does not differ among under-, acceptable, and over-reporters of energy intake

Author:
Kentaro Murakami; Satoshi Sasaki; Kazuhiro Uenishi; Japan Dietetic Students’ Study for Nutrition and Biomarkers Group
Source:
Nutrition research 2012 v.32 no.10 pp. 741-750
ISSN:
0271-5317
Subject:
correlation; diet history; dietary protein; energy intake; energy requirements; excretion; nutrient density; nutrients; potassium; protein intake; proteins; questionnaires; sodium; women
Abstract:
... It is unclear whether misreporting of nutrient intakes differs according to energy reporting status. We examined misreporting of dietary protein, potassium, and sodium in under-, acceptable, and over-reporters of energy intake. Our hypothesis was that degree of misreporting of these three nutrients differs among under-, acceptable, and over-reporters. Participants were 1043 Japanese women aged 18 ...
DOI:
10.1016/j.nutres.2012.09.001
PubMed:
23146770

24. Individuals’ half-lives for 2,3,4,7,8-penta-chlorodibenzofuran (PeCDF) in blood: Correlation with clinical manifestations and laboratory results in subjects with Yusho

Author:
Shinya Matsumoto; Manabu Akahane; Yoshiyuki Kanagawa; Jumboku Kajiwara; Takashi Todaka; Fumiko Yasukawa; Hiroshi Uchi; Masutaka Furue; Tomoaki Imamura
Source:
Chemosphere 2013 v.92 pp. 772-777
ISSN:
0045-6535
Subject:
erythrocyte count; erythrocytes; excretion; half life; hay fever; ingestion; linear models; lipids; patients; people; poisoning; Japan
Abstract:
... In 1968, many people developed dioxin poisoning (Yusho) in Japan. Ingestion of 2,3,4,7,8-pentachlorodibenzofuran (2,3,4,7,8-PeCDF) was considered to be the cause of this poisoning. Although some patients had high concentrations of 2,3,4,7,8-PeCDF in their blood, individuals’ half-lives of 2,3,4,7,8-PeCDF were long.To evaluate the relationship between clinical and laboratory parameters and the indi ...
DOI:
10.1016/j.chemosphere.2013.04.005
PubMed:
23651555

25. Theflavins and Theasinensin A Derived from Fermented Tea Have Antihyperglycemic and Hypotriacylglycerolemic Effects in KK-Ay Mice and Sprague–Dawley Rats

Author:
Miyata Yuji; Tamaru Shizuka; Tanaka Takashi; Tamaya Kei; Matsui Toshiro; Nagata Yasuo; Tanaka Kazunari
Source:
Journal of agricultural and food chemistry 2013 v.61 no.39 pp. 9366-9372
ISSN:
1520-5118
Subject:
absorption; blood glucose; diet; excretion; fatty-acid synthase; mice; oral administration; polyphenols; rats; tea; triacylglycerols
Abstract:
... Although tea polyphenols are reported to improve serum glucose and lipid levels by inhibiting amylase activity and reducing lipid absorption, in vivo data are lacking. We evaluated in vivo the antihyperglycemic and hypotriacylglycerolemic effects of theaflavins (TFs) and theasinensin A (TSA) refined from fermented tea to purities of 12 and 59%, respectively. Feeding male KK-Aʸ mice diets with 0.1% ...
DOI:
10.1021/jf400123y
PubMed:
24011231

26. A Toxin Isolated from Sarcocystis fayeri in Raw Horsemeat May Be Responsible for Food Poisoning

Author:
Kamata, Yoichi; Saito, Morihiro; Irikura, Daisuke; Yahata, Yuichiro; Ohnishi, Takahiro; Bessho, Tomoaki; Inui, Takashi; Watanabe, Maiko; Sugita-Konishi, Yoshiko
Source:
Journal of food protection 2014 v.77 no.5 pp. 814-819
ISSN:
0362-028X
Subject:
Eimeria tenella; Sarcocystis; Toxoplasma gondii; amino acid sequences; diarrhea; dogs; excretion; foodborne illness; horse meat; ileum; intravenous injection; parasitism; patients; poisoning; rabbits; toxicity; Japan
Abstract:
... Food poisoning has been reported after the consumption of raw horsemeat in Japan. Diarrhea with a short incubation period is a common symptom in such cases of food poisoning. Cysts found in horsemeat ingested by patients have been identified as Sarcocystis fayeri based on morphological and genetic evaluation and findings from experimental feeding of cysts to dogs, which resulted in the excretion o ...

27. Clinical implication of SGLT2 inhibitors in type 2 diabetes

Author:
Go Woon Kim; Sung Hyun Chung
Source:
Archives of pharmacal research 2014 v.37 no.8 pp. 957-966
ISSN:
0253-6269
Subject:
adverse effects; clinical trials; excretion; glucose; glycemic control; hyperglycemia; hypoglycemia; hypoglycemic agents; insulin secretion; kidneys; markets; noninsulin-dependent diabetes mellitus; patients; sodium; weight gain; Japan; United States
Abstract:
... Treatment of type 2 diabetes mellitus (T2DM) continues to present challenges, with many patients failing to achieve glycemic targets. Despite the availability of many oral and injectable anti-diabetic agents, therapeutic efficacy is often offset by undesirable side effects such as hypoglycemia, weight gain and cardiovascular complications. Therefore, the search for new therapeutic agents with an i ...
DOI:
10.1007/s12272-014-0419-0

28. Diuretic and anti-diuretic activities of fractions of Alismatis rhizoma

Author:
Dan-Qian Chen; Ya-Long Feng; Ting Tian; Hua Chen; Lu Yin; Ying-Yong Zhao; Rui-Chao Lin
Source:
Journal of ethnopharmacology 2014 v.157 pp. 114-118
ISSN:
0378-8741
Subject:
Alisma orientale; Oriental traditional medicine; butanol; diuresis; electrolytes; ethanol; ethyl acetate; excretion; oral administration; pH; petroleum; rats; renal function; rhizomes; sodium; sodium chloride; urine; China; Japan
Abstract:
... Alismatis rhizoma or Alisma orientale (Zexie in Chinese), the dried rhizome of Alisma orientale Juzepzuk (Alismataceae), is a well-known traditional Chinese medicine and is used as an agent for diuresis and for excreting dampness in China and Japan. In this paper, we report the diuretic activities of the petroleum ether fraction, the ethyl acetate fraction, the n-buthanol fraction, and the remaini ...
DOI:
10.1016/j.jep.2014.09.022

29. Estimation of sodium and potassium intakes assessed by two 24 h urine collections in healthy Japanese adults: a nationwide study

Author:
Keiko Asakura; Ken Uechi; Yuki Sasaki; Shizuko Masayasu; Satoshi Sasaki
Source:
British journal of nutrition 2014 v.112 no.7 pp. 1195-1205
ISSN:
1475-2662
Subject:
World Health Organization; adults; body mass index; data collection; excretion; females; males; men; potassium; risk factors; sodium; urine; women; Japan
Abstract:
... Excess Na intake and insufficient K intake are well-known risk factors for CVD. International comparative studies have reported that Japan has the highest intake of Na and the lowest intake of K in the world. However, no recent study has precisely assessed Na and K intakes in Japanese adults. In the present study, Na and K intakes were estimated from two 24 h urine collections implemented in twent ...
DOI:
10.1017/S0007114514001779
PubMed:
25111316

30. Experimental infection of cattle and goats with a foot-and-mouth disease virus isolate from the 2010 epidemic in Japan

Author:
Hiroyuki Onozato; Katsuhiko Fukai; Rie Kitano; Reiko Yamazoe; Kazuki Morioka; Manabu Yamada; Seiichi Ohashi; Kazuo Yoshida; Toru Kanno
Source:
Archives of virology 2014 v.159 no.11 pp. 2901-2908
ISSN:
0304-8608
Subject:
Foot-and-mouth disease virus; RNA; cattle; direct contact; excretion; goats; quantitative analysis; risk analysis; viral load; Japan
Abstract:
... In this study, we carried out experimental infections in cattle and goats using a foot-and-mouth disease virus (FMDV) isolate from the 2010 epidemic in Japan to analyze clinical manifestations, virus-shedding patterns and antibody responses in the animals. We found that the FMDV O/JPN/2010 isolate is virulent in cattle and goats, produces clinical signs, is spread efficiently by direct contact wit ...
DOI:
10.1007/s00705-014-2135-y
PubMed:
24938483

31. Interlinked seasonal variation in biogenic nutrient fluxes and pore-water nutrient concentrations in intertidal sediments

Author:
P. Magni; S. Como; S. Montani; H. Tsutsumi
Source:
Marine biology 2014 v.161 no.12 pp. 2767-2779
ISSN:
0025-3162
Subject:
Ruditapes philippinarum; ammonium compounds; autumn; chlorophyll; excretion; nitrates; nitrites; phosphates; seasonal variation; sediments; silica; summer; Japan
Abstract:
... The seasonal variation in biogenic fluxes of NH₄ ⁺, PO₄ ³⁻ and SiO₂ calculated from the nutrient excretion rates of dominant bivalves (Ruditapes philippinarum and Arcuatula [=Musculista] senhousia), and pore-water nutrient (NH₄ ⁺, PO₄ ³⁻, SiO₂ and NO₃ ⁻ + NO₂ ⁻), sedimentary acid-volatile sulfide (AVS) and benthic chlorophyll-a (Chl-a) concentrations was assessed on an intertidal sandflat in the S ...
DOI:
10.1007/s00227-014-2541-4

32. Self-Reported Taste Preference Can Be a Proxy for Daily Sodium Intake in Middle-Aged Japanese Adults

Author:
Ribeka Takachi; Junko Ishihara; Motoki Iwasaki; Yuri Ishii; Shoichiro Tsugane
Source:
Journal of the Academy of Nutrition and Dietetics 2014 v.114 no.5 pp. 781-787
ISSN:
2212-2672
Subject:
chronic diseases; cooking; cross-sectional studies; excretion; food choices; food frequency questionnaires; food records; men; middle-aged adults; miso; neoplasms; regression analysis; screening; sodium; soups; table salt; urine; women; Japan
Abstract:
... Reducing dietary salt intake remains a challenging issue in the management of chronic disease. Taste preference is suspected to be an important proxy index of daily sodium consumption. This study examined the difference in daily sodium intake according to self-reported taste preference for miso soup as representative of homemade cooking in middle-aged urban Japanese adults. Among 896 candidates ra ...
DOI:
10.1016/j.jand.2013.07.043

33. The JFFMA assessment of flavoring substances structurally related to menthol and uniquely used in Japan

Author:
Yoshiharu Mirokuji; Hajime Abe; Hiroyuki Okamura; Kenji Saito; Fumiko Sekiya; Shim-mo Hayashi; Shinpei Maruyama; Atsushi Ono; Madoka Nakajima; Masakuni Degawa; Shogo Ozawa; Makoto Shibutani; Tamio Maitani
Source:
Food and chemical toxicology 2014 v.64 pp. 314-321
ISSN:
0278-6915
Subject:
Food and Agriculture Organization; World Health Organization; average daily intake; chemical structure; excretion; food additives; foods; genotoxicity; ingestion; menthol; palmitates; stearic acid; toxicology; Japan
Abstract:
... Using the procedure devised by the Joint FAO/WHO Expert Committee on Food Additives (JECFA), we performed safety evaluations on four flavoring substances structurally related to menthol (l-menthyl 2-methylbutyrate, dl-menthyl octanoate, dl-menthyl palmitate, and dl-menthyl stearate) uniquely used in Japan. While no genotoxicity study data were available in the literature, all four substances had n ...
DOI:
10.1016/j.fct.2013.11.044

34. Urinary monohydroxylated metabolites of polycyclic aromatic hydrocarbons in children living in city and rural residences in Southern China

Author:
Yu Wang; Ruifang Fan; Yulian Dong; Wenbing Zhang; Guoying Sheng; Jiamo Fu
Source:
Environmental technology 2014 v.35 no.23 pp. 2973-2981
ISSN:
1479-487X
Subject:
air; children; creatinine; environmental technology; excretion; metabolites; parents; polycyclic aromatic hydrocarbons; soil; students; China; Denmark; Germany; Japan; Korean Peninsula; Spain; Taiwan; Thailand; Ukraine; United States
Abstract:
... Urinary 2-hydroxynaphthalene, 2-hydoxyfluorene, 9-hydroxyphenanthrene, 1-hydroxypyrene and 3-hydroxybenz[a]pyrene concentrations in 179 randomly selected voluntary students were determined in the Southern China, aged 14–16 and living in four areas with different levels of polycyclic aromatic hydrocarbons (PAHs) in soil, water and ambient air. The excretion of 1-hydroxypyrene is significantly highe ...
DOI:
10.1080/09593330.2014.927532

35. Dietary patterns extracted from the current Japanese diet and their associations with sodium and potassium intakes estimated by repeated 24 h urine collection

Author:
Aya Fujiwara; Keiko Asakura; Ken Uechi; Shizuko Masayasu; Satoshi Sasaki
Source:
Public health nutrition 2016 v.19 no.14 pp. 2580-2591
ISSN:
1475-2727
Subject:
adults; breads; eating habits; excretion; factor analysis; fish; food frequency questionnaires; food groups; meat; men; oils; potassium; sodium; urine; vegetables; women; Japan
Abstract:
... To identify dietary patterns in the current Japanese diet and evaluate the associations between these patterns and Na and K intakes. Dietary patterns were extracted by factor analysis from the intakes of food groups assessed with a validated self-administrated diet history questionnaire. Na and K intakes and urinary Na:K were assessed by repeated 24 h urine collection. Healthy Japanese adults aged ...
DOI:
10.1017/S1368980016000641
PubMed:
27048947

36. Effects of dietary protein levels on the growth, energy budget, and physiological and immunological performance of green, white and purple color morphs of sea cucumber, Apostichopus japonicus

Author:
Yucen Bai; Libin Zhang; Sudong Xia; Shilin Liu; Xiaoshang Ru; Qinzeng Xu; Tao Zhang; Hongsheng Yang
Source:
Aquaculture 2016 v.450 pp. 375-382
ISSN:
0044-8486
Subject:
Apostichopus japonicus; ammonia; aquaculture; aspartate transaminase; catalase; color; crude protein; dietary protein; digestibility; digestion; energy; excretion; fish meal; food conversion; growth performance; immune system; ingestion; low protein diet; malondialdehyde; morphs; protein metabolism; protein sources; soybean meal; specific growth rate; superoxide dismutase; trypsin; China; Japan; South Korea
Abstract:
... Protein is a necessary nutrient for the sea cucumber, Apostichopus japonicus, an important commercial species in China, South Korea and Japan. In this study, the dietary protein requirements of two newly discovered color morphs—white and purple was investigated and compared with the common, green morph. The green, white and purple morphs were fed a diet with five different protein levels (1, 6, 11 ...
DOI:
10.1016/j.aquaculture.2015.08.021

37. Protection Afforded by a Recombinant Turkey Herpesvirus-H5 Vaccine Against the 2014 European Highly Pathogenic H5N8 Avian Influenza Strain

Author:
Steensels M.; Rauw F.; van den Berg Th.; Marché S.; Gardin Y.; Palya V.; Lambrecht B.
Source:
Avian diseases 2016 v.60 no.1s pp. 202-209
ISSN:
0005-2086
Subject:
endemic diseases; genes; wild birds; vaccination; Galliformes; viruses; coasts; viral shedding; monitoring; morbidity; eggs; mortality; excretion; chickens; specific pathogen-free animals; Meleagrid alphaherpesvirus 1; vaccines; avian influenza; cloaca; poultry industry; Germany; Netherlands; Italy; Hungary; South Korea; Japan; China; United Kingdom
Abstract:
... A highly pathogenic avian influenza (HPAI) H5N8 (clade 2.3.4.4) virus, circulating in Asia (South Korea, Japan, and southern China) since the beginning of 2014, reached the European continent in November 2014. Germany, the Netherlands, the United Kingdom, Italy, and Hungary confirmed H5N8 infection of poultry farms of different species and of several wild bird species. Unlike the Asian highly path ...
DOI:
10.1637/11126-050615-Reg.1

38. Relationship of nutrition knowledge and self-reported dietary behaviors with urinary excretion of sodium and potassium: comparison between dietitians and nondietitians

Author:
Minami Sugimoto; Keiko Asakura; Shizuko Masayasu; Satoshi Sasaki
Source:
Nutrition research 2016 v.36 pp. 440-451
ISSN:
0271-5317
Subject:
adults; covariance; cross-sectional studies; dietitians; excretion; females; food intake; food labeling; fruits; nutrition knowledge; oils; potassium; questionnaires; smoking (habit); sodium; sugars; urine; vegetables; women; Japan
Abstract:
... The effectiveness of better nutrition knowledge and dietary behavior on healthier dietary intake is still controversial. We hypothesized that nutritional knowledge and dietary behavior are associated with sodium and potassium intake in adult women. A cross-sectional study was conducted at welfare facilities located in 20 areas of Japan. Ninety-nine female dietitians and 117 nondietitians aged 20 t ...
DOI:
10.1016/j.nutres.2015.12.012

39. Status of 137Cs contamination in marine biota along the Pacific coast of eastern Japan derived from a dynamic biological model two years simulation following the Fukushima accident

Author:
Yutaka Tateda; Daisuke Tsumune; Takaki Tsubono; Kazuhiro Misumi; Masatoshi Yamada; Jota Kanda; Takashi Ishimaru
Source:
Journal of environmental radioactivity 2016 v.151 pp. 495-501
ISSN:
0265-931X
Subject:
Paralichthys olivaceus; accidents; cesium; coastal water; coasts; demersal fish; detritivores; detritus; diet; excretion; flounder; food chain transfer; ingestion; invertebrates; models; nuclear power; planktivores; power plants; radioactivity; radionuclides; seafoods; sediments; water pollution; Japan; Pacific Ocean
Abstract:
... Radiocesium (¹³⁴Cs and ¹³⁷Cs) released into the Fukushima coastal environment was transferred to marine biota inhabiting the Pacific Ocean coastal waters of eastern Japan. Though the levels in most of the edible marine species decreased overtime, radiocesium concentrations in some fishes were still remained higher than the Japanese regulatory limit for seafood products. In this study, a dynamic fo ...
DOI:
10.1016/j.jenvrad.2015.05.013

40. Bletilla striata: Medicinal uses, phytochemistry and pharmacological activities

Author:
Xirui He; Xiaoxiao Wang; Jiacheng Fang; Zefeng Zhao; Linhong Huang; Hao Guo; Xiaohui Zheng
Source:
Journal of ethnopharmacology 2017 v.195 pp. 20-38
ISSN:
0378-8741
Subject:
anti-inflammatory activity; plant biochemistry; immunomodulation; polysaccharides; anthrax; tissue repair; saponins; triterpenoids; tuberculosis; eye diseases; databases; traditional medicine; metabolism; hemostasis; cytotoxicity; bioactive compounds; excretion; topical application; steroids; phenanthrenes; absorption; hemorrhage; Lipotes vexillifer; Bletilla striata; drug formulations; chronic toxicity; Mongolia; Korean Peninsula; Japan; China
Abstract:
... Bletilla striata (Thunb.) Reichb. f. (Orchidaceae), also known as Hyacinth Orchid and Baiji (Simplified Chinese: 白及), not only has been widely used for the treatment of hematemesis, hemoptysis, and traumatic bleeding due to the efficacy of arresting bleeding with astringent action, but also has been applied topically to overcome ulcers, sores, swellings, and chapped skin due to the efficacy of dis ...
DOI:
10.1016/j.jep.2016.11.026

41. Estimation of nutrient excretion factors of broiler and layer chickens in Japan

Author:
Akifumi Ogino; Hitoshi Murakami; Takahiro Yamashita; Motohiro Furuya; Hirofumi Kawahara; Takako Ohkubo; Takashi Osada
Source:
Animal science journal = 2017 v.88 no.4 pp. 659-668
ISSN:
1344-3941
Subject:
eggs; excretion; feed conversion; feeds; laying hens; liveweight gain; magnesium; nitrogen; nutrients; phosphorus; potassium; Japan
Abstract:
... We estimated the nitrogen (N), phosphorus (P), potassium (K) and magnesium (Mg) excretion factors of broiler and layer chickens in Japan, using two approaches and the latest data available. In the top‐down approach, we determined the nutrient amounts in the feeds and those in the products (i.e. the liveweight gain, eggs), and the national nutrient excretions were determined as the difference betwe ...
DOI:
10.1111/asj.12674

42. Current state of yusho and prospects for therapeutic strategies

Author:
Chikage Mitoma; Hiroshi Uchi; Kiyomi Tsukimori; Takashi Todaka; Jumboku Kajiwara; Takayuki Shimose; Manabu Akahane; Tomoaki Imamura; Masutaka Furue
Source:
Environmental science and pollution research international 2018 v.25 no.17 pp. 16472-16480
ISSN:
0944-1344
Subject:
antioxidants; blood; chelating agents; clinical trials; dietary fiber; excretion; foodborne illness; ingestion; lipophilicity; patients; phytopharmaceuticals; poisoning; polychlorinated biphenyls; polychlorinated dibenzodioxins; polychlorinated dibenzofurans; rice bran oil; signal transduction; therapeutics; toxicity; Japan
Abstract:
... The mass food poisoning incident yusho occurred in Japan in 1968. It was caused by the ingestion of rice bran oil contaminated with polychlorinated biphenyls and various dioxins and dioxin-like compounds including polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDFs). Notably, PCDFs were found to contribute to approximately 65% of the total toxicity equivalent in the blood of ...
DOI:
10.1007/s11356-017-0833-1

43. Echinococcus multilocularis Surveillance Using Copro-DNA and Egg Examination of Shelter Dogs from an Endemic Area in Hokkaido, Japan

Author:
Takao Irie; Takeshi Mukai; Kinpei Yagi
Source:
Vector borne and zoonotic diseases 2018 v.18 no.7 pp. 390-392
ISSN:
1557-7759
Subject:
Echinococcus multilocularis; deworming; dogs; eggs; excretion; human diseases; monitoring; parasites; risk; urban areas; voles; Japan
Abstract:
... Surveillance of Echinococcus multilocularis infection among 156 shelter dogs was conducted in an urban area (Sapporo city) in Hokkaido, where the parasite is endemic in Japan using copro-DNA and fecal egg examination from September 2013 to April 2017. Echinococcus infection was detected in three dogs (1.9%), including one dog that excreted eggs. The results suggested that free-roaming or stray dog ...
DOI:
10.1089/vbz.2017.2245

44. Hypolipidemic effect of water‐extractive components from funazushi: A fermented product of crucian carp

Author:
Koji Ito
Source:
Journal of food biochemistry 2018 v.42 no.6 pp. e12700
ISSN:
0145-8884
Subject:
Carassius; bile acids; blood lipids; cholesterol; excretion; fermented foods; functional foods; intestines; lipemic effect; micelles; rats; solubility; triacylglycerols; Japan
Abstract:
... To verify minor physiological functions of funazushi and its water‐extractive components (extracts), the hypolipidemic effects of extracts from funazushi, a traditional fermented crucian carp in Japan, were examined. Administration of funazushi extract to rats suppressed the plasma levels of cholesterol and triglycerides and tended to increase the fecal levels of triglycerides, cholesterol, and bi ...
DOI:
10.1111/jfbc.12700

45. Seasonal variation in food web-based transfer factors of radiocesium in white-spotted char (Salvelinus leucomaenis) from headwater streams

Author:
M. E. Haque; T. Gomi; M. Sakai; J. N. Negishi
Source:
Landscape and ecological engineering 2018 v.14 no.1 pp. 45-53
ISSN:
1860-1871
Subject:
Internet; Salvelinus leucomaenis; accidents; bioaccumulation; cesium; excretion; landscapes; metabolism; nuclear power; power plants; predator-prey relationships; radionuclides; seasonal variation; stable isotopes; streams; summer; winter; Japan
Abstract:
... The seasonal variability of food web-based transfer factors (TF wₑb) of radiocesium (¹³⁷Cs) in white-spotted char (Salvelinus leucomaenis) was examined in the 2nd and 3rd year after the Fukushima Daiichi Nuclear Power Plant accident. Two headwater streams with similar landscape characteristics, but different amounts of fallout, were selected in Fukushima and Gunma Prefectures, Japan. The TF wₑb of ...
DOI:
10.1007/s11355-016-0324-4

46. Effects of calcium application on the salt tolerance and sodium excretion from salt glands in zoysiagrass (Zoysia japonica)

Author:
Yoshiyuki Maeda
Source:
Grassland science 2019 v.65 no.3 pp. 189-196
ISSN:
1744-6961
Subject:
Zoysia japonica; adenosinetriphosphatase; ascorbate peroxidase; betaine; calcium; calcium chloride; catalase; enzyme activity; excretion; growth retardation; indigenous species; oxidative stress; plasma membrane; proline; roots; salt glands; salt stress; salt tolerance; shoots; sodium; sodium chloride; tissues; turf grasses; warm season; Japan
Abstract:
... Zoysiagrass (Zoysia japonica Steud.), a native grass in Japan, is a warm‐season turfgrass displaying high salt tolerance, mainly derived from salt excretion through salt glands. The present study focused on how external calcium (Ca) affects sodium (Na) excretion from salt glands to relieve salt stress, including response to oxidative stress, and discussed the physiological mechanisms possibly invo ...
DOI:
10.1111/grs.12234

47. Seed Feeding Behavior of Diplothrix legata (Muridae: Rodentia): Effects on Germination of Five Plants in Okinawajima Island, Japan

Author:
Reina Nago; Shun Kobayashi; Teruo Kinjo; Kozue Ogimi; Akari Sinjo; Shinobu Namisato; Anna Futamatagawa; Genwa Higa; Masako Izawa
Source:
Mammal study 2019 v.44 no.2 pp. 129-134
ISSN:
1348-6160
Subject:
Actinidia; Ficus erecta; Melastoma candidum; Muridae; Prunus campanulata; Zinnia; excretion; feces; feeding behavior; fruits; germination; granivores; rats; raw fruit; seeds; Japan
Abstract:
... This study examined how seed feeding by the Ryukyu long-furred rat Diplothrix legata affects germination of five plants (Cerasus campanulata, Actinidia rufa, Ficus erecta, Oreocnide pedunculata, and Melastoma candidum) in Okinawajima Island, Japan. The germination rates of seeds from fresh fruit and fecal pellets of two captive rats, as well as the feeding behaviors, were observed. Most of C. camp ...
DOI:
10.3106/ms2018-0049

48. Tasty waste: industrial fermentation and the creative destruction of MSG

Author:
Sarah E. Tracy
Source:
Food, culture, & society 2019 v.22 no.5 pp. 548-565
ISSN:
1751-7443
Subject:
aesthetic value; agricultural wastes; bacteria; beverages; drugs; excretion; fermentation; flavorings; food additives; food industry; foodways; glutamic acid; industrial wastes; markets; monosodium glutamate; processed foods; profitability; raw materials; soybeans; sugars; wheat; Japan; United States
Abstract:
... Monosodium glutamate (MSG) traveled to America in the Pacific theatre of World War II. The flavor-enhancing food additive was known in the U.S. beforehand, but it was the experience of Japanese military rationing that drove American military and food industry interests to truly adopt the technology and to invest in domestic production. In 1957, researchers in Japan discovered a method of producing ...
DOI:
10.1080/15528014.2019.1638117

49. Association of Dietary Acid Load with the Prevalence of Metabolic Syndrome among Participants in Baseline Survey of the Japan Multi-Institutional Collaborative Cohort Study

Author:
Kokichi Arisawa; Sakurako Katsuura-Kamano; Hirokazu Uemura; Nguyen Van Tien; Asahi Hishida; Takashi Tamura; Yoko Kubo; Mineko Tsukamoto; Keitaro Tanaka; Megumi Hara; Toshiro Takezaki; Daisaku Nishimoto; Teruhide Koyama; Etsuko Ozaki; Sadao Suzuki; Takeshi Nishiyama; Kiyonori Kuriki; Aya Kadota; Naoyuki Takashima; Hiroaki Ikezaki; Masayuki Murata; Isao Oze; Keitaro Matsuo; Haruo Mikami; Yohko Nakamura; Kenji Takeuchi; Kenji Wakai
Source:
Nutrients 2020 v.12 no.6 pp. -
ISSN:
2072-6643
Subject:
Japan; age; blood glucose; body mass index; carbohydrate intake; cohort studies; confidence interval; cross-sectional studies; excretion; hypertension; iron; metabolic syndrome; obesity; odds ratio; potassium; prevalence; waist circumference
Abstract:
... The association between dietary acid load and metabolic syndrome (MetS) has not been fully investigated. A cross-sectional study was performed on 14,042 men and 14,105 women (aged 35–69 years) who participated in a baseline survey of the Japan Multi-Institutional Collaborative Cohort study. Dietary acid load was assessed using the net-endogenous-acid-production (NEAP) score that is closely correla ...
DOI:
10.3390/nu12061605

50. Biological Activity-Based Prioritization of Pharmaceuticals in Wastewater for Environmental Monitoring: G Protein-Coupled Receptor Inhibitors

Author:
Han Zhang; Mariko O. Ihara; Norihide Nakada; Hiroaki Tanaka; Masaru Ihara
Source:
Environmental science & technology 2020 v.54 no.3 pp. 1720-1729
ISSN:
1520-5851
Subject:
G-protein coupled receptors; Japan; acetylcholine; aquatic organisms; dopamine; excretion; histamine; prioritization; technology; toxicity; wastewater; England
Abstract:
... Pharmaceuticals raise concerns for aquatic species owing to their biological activities. It is estimated that nearly 40% of marketed pharmaceuticals target G protein-coupled receptors (GPCRs). Using an in vitro transforming growth factor-α (TGFα) shedding assay, we previously detected antagonistic activities of GPCR-acting pharmaceuticals against angiotensin (AT1), dopamine (D2), acetylcholine (M1 ...
DOI:
10.1021/acs.est.9b05768