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- Author:
- Lee, Chia-Lin; Huang, Po-Ching; Hsieh, Pei-Wen; Hwang, Tsong-Long; Hou, Yu-Yi; Chang, Fang-Rong; Wu, Yang-Chang
- Source:
- Planta medica 2008 v.74 no.10 pp. 1276-1279
- ISSN:
- 0032-0943
- Subject:
- cytotoxins; Xanthium strumarium; seeds; humans; cytotoxicity; pyrans; medicinal plants; aldehydes; superoxide anion; neutrophils; cultured cells; spectral analysis; xanthine; chemical structure; Oriental traditional medicine; anticarcinogenic activity
- DOI:
- 10.1055/s-2008-1081295
- https://doi.org/10.1055/s-2008-1081295
- Author:
- Jun-Sheng TIAN; Lei ZHAO; Xiao-Li SHEN; Huan LIU; Xue-Mei QIN
- Source:
- Chinese journal of natural medicines 2018 v.16 no.4 pp. 261-270
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; amino acid metabolism; animal disease models; biochemical pathways; cytotoxicity; diabetic nephropathy; energy metabolism; glycemic effect; ketone bodies; kidneys; metabolomics; methylamine; nuclear magnetic resonance spectroscopy; patients; protective effect; rats; renal function; serine; threonine; urinalysis
- Abstract:
- ... Diabetic nephropathy is one of the various complications of diabetes mellitus, affecting patients for lifetime. Earlier studies have revealed that genipin can not only improve diabetes, but also induce cytotoxicity. Therefore, it is not clear which effect of genipin on kidneys occurs, when it is used in the treatment of diabetes. In the present study, we performed nuclear magnetic resonance (NMR)- ...
- DOI:
- 10.1016/S1875-5364(18)30056-6
- https://doi.org/10.1016/S1875-5364(18)30056-6
- Author:
- Li-Juan Deng; Yu-He Lei; Jing-Yu Quan; Bao-Jing Li; Dong-Mei Zhang; Hai-Yan Tian; Ye Chen; En-Xin Zhang; Lei Chen; Wen-Cai Ye; Wei-Min Ning; Lin-Zhong Yu; Jun-Shan Liu
- Source:
- Journal of ethnopharmacology 2021 v.266 pp. 113443
- ISSN:
- 0378-8741
- Subject:
- Bufonidae; Danio rerio; Oriental traditional medicine; apoptosis; cancer therapy; caspase-3; caspase-9; cytotoxicity; drugs; hepatoma; humans; membrane potential; mitochondria; mitochondrial membrane; models; toxicity testing; transfection; xenotransplantation
- Abstract:
- ... Chansu, dried secretions from Bufonidae, has long been used for cancer treatment as a traditional Chinese medicine. In searching for effective anti-hepatoma agents from Chansu, our preliminary drug screening found that a bufadienolide, namely 1β-hydroxyl-arenobufagin (1β–OH–ABF), displays anti-hepatoma activities. However, the anti-hepatoma effects and molecular mechanisms of 1β–OH–ABF have not be ...
- DOI:
- 10.1016/j.jep.2020.113443
- https://doi.org/10.1016/j.jep.2020.113443
- Author:
- Ni, Gang; Zhang, Qing-Jian; Zheng, Zhong-Fei; Chen, Ruo-Yun; Yu, De-Quan
- Source:
- Journal of natural products 2009 v.72 no.5 pp. 966-968
- ISSN:
- 0163-3864
- Subject:
- human cell lines; phytochemicals; cytotoxicity; plant extracts; furans; bark; chemical structure; Oriental traditional medicine; anticarcinogenic activity
- DOI:
- 10.1021/np800789y
- PubMed:
- 19338315
- https://doi.org/10.1021/np800789y
- Author:
- Zheng, Yuanting; Zhou, Fang; Wu, Xiaolan; Wen, Xiaozhou; Li, Yannan; Yan, Bei; Zhang, Jingwei; Hao, Gang; Ye, Wencai; Wang, Guangji
- Source:
- Journal of ethnopharmacology 2010 v.128 no.3 pp. 615-622
- ISSN:
- 0378-8741
- Subject:
- doxorubicin; sarcoma; animal disease models; cytotoxicity; medicinal plants; drug adjuvants; physicochemical properties; mice; triterpenoids; drug synergism; cell lines; Oriental traditional medicine; anticarcinogenic activity
- Abstract:
- ... Ethnopharmacological revelance: Pulsatilla chinensis (Bunge) Regel has been used as adjuvant in chemotherapy in traditional Chinese medicine. 23-Hydroxybetulinic acid, an isolated pentacyclic triterpene, is the major active constituent of Pulsatilla chinensis (Bunge) Regel. Aim of this study: To evaluate the combinational anticancer effect of 23-hydroxybetulinic acid and doxorubicin in vitro and i ...
- DOI:
- 10.1016/j.jep.2010.02.004
- PubMed:
- 20176097
- https://doi.org/10.1016/j.jep.2010.02.004
- Author:
- Birgit Lohberger; Nadine Kretschmer; Eva Bernhart; Beate Rinner; Nicole Stuendl; Heike Kaltenegger; Stefan Kahl; Rudolf Bauer; Andreas Leithner
- Source:
- Journal of ethnopharmacology 2015 v.164 pp. 265-272
- ISSN:
- 0378-8741
- Subject:
- Oriental traditional medicine; Quisqualis; Western blotting; apoptosis; branches; caspase-3; cell cycle checkpoints; cell proliferation; cell viability; cyclin-dependent kinase; cyclins; cytotoxicity; dose response; drug therapy; human cell lines; leaves; metastasis; mitosis; neoplasm cells; pro-apoptotic proteins; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; sarcoma; tissues
- Abstract:
- ... Quisqualis indica is used in traditional Chinese medicine to treat cancer and related syndromes and also known for its anthelminthic effects.Soft tissue sarcomas represent a rare group of malignant tumors that frequently exhibit chemotherapeutic resistance and increased metastatic potential. In this study, we evaluated the cytotoxic, apoptosis inducing and cell cycle arresting effects of 25-O-acet ...
- DOI:
- 10.1016/j.jep.2015.02.023
- https://doi.org/10.1016/j.jep.2015.02.023
- Author:
- Jing Gao; Lan Gao; Li Zhang; Weifeng Yao; Yudan Cao; Beihua Bao; Anwei Ding
- Source:
- Journal of ethnopharmacology 2015 v.174 pp. 331-338
- ISSN:
- 0378-8741
- Subject:
- Euphorbia kansui; Oriental traditional medicine; Western blotting; apoptosis; asthma; caspase-3; cell cycle checkpoints; cytochrome c; cytosol; cytotoxicity; diterpenoids; dose response; edema; enzyme-linked immunosorbent assay; ethyl acetate; inhibitory concentration 50; intestinal mucosa; membrane potential; mitochondria; mitochondrial membrane; rats; reactive oxygen species; screening; staining; transmission electron microscopes; transmission electron microscopy; China
- Abstract:
- ... Euphorbia kansui is a traditional Chinese medicine widely used for the treatment of edema, ascite and asthma in China for centuries. However, its serious gastrointestinal toxicity restricted its safe clinical application. 3-O-(2′E,4′Z-decadienoyl)-20-O-acetylingenol (3EZ,20Ac-ingenol), a diterpenoid compound derived from kansui, has obvious gastrointestinal cytotoxicity in cells. Until now, its ga ...
- DOI:
- 10.1016/j.jep.2015.08.036
- https://doi.org/10.1016/j.jep.2015.08.036
- Author:
- Lin-Yun Mou; Min Wei; Hai-Yan Wu; Li-Jiao Hu; Jian-Long Li; Gan-Peng Li
- Source:
- Natural product research 2021 v.36 no.1 pp. 237-245
- ISSN:
- 1478-6427
- Subject:
- Oriental traditional medicine; Swertia; anti-inflammatory activity; chemotaxonomy; cytotoxicity; glycosides; humans; medicinal plants; metabolites; neoplasm cells; nitric oxide; research; spectral analysis; tetrazolium
- Abstract:
- ... A new chromone glycoside, 8-O-β-D-Glucopyranosyl-2-methylchromone (1), together with eight known compounds (2–9) were isolated from the Tibetan medicine plant of Swertia punicea. All compounds of this plant were reported for the first time. The structures of these metabolites were elucidated by analysis of their HR–ESI–MS, 1D and 2D NMR spectroscopic data and comparison with data reported in the l ...
- DOI:
- 10.1080/14786419.2020.1777123
- https://doi.org/10.1080/14786419.2020.1777123
- Author:
- Lin, P.; Li, S.; Wang, S.; Yang, Y.; Shi, J.
- Source:
- Journal of natural products 2006 v.69 no.11 pp. 1629-1632
- ISSN:
- 0163-3864
- Subject:
- benzoquinones; lactones; humans; phytochemicals; cytotoxicity; anticarcinogenic activity; medicinal plants; furans; secondary metabolites; cultured cells; spectral analysis; chemical structure; Oriental traditional medicine; Embelia ribes; China
- DOI:
- 10.1021/np060284m
- PubMed:
- 17125236
- https://doi.org/10.1021/np060284m
- Author:
- Jingjing Zhang; Yangliu Tong; Xun Lu; Fangming Dong; Xiaoxuan Ma; Shiyu Yin; Ying He; Yonghong Liu; Qingchao Liu; Daidi Fan
- Source:
- Life sciences 2022 v.304 pp. 120698
- ISSN:
- 0024-3205
- Subject:
- Oriental traditional medicine; acetylation; adverse effects; antineoplastic activity; apoptosis; cytotoxicity; death; flow cytometry; fluorescent antibody technique; ginsenosides; growth and development; hepatoma; immunoblotting; models; neoplasm cells; phosphorylation; transcription factors; transcriptomics; xenotransplantation
- Abstract:
- ... Epidemiological studies have shown that hepatocellular carcinoma (HCC) is a main cause of tumor death worldwide. Accumulating data indicate that ginsenoside CK is an effective compound for preventing HCC growth and development. However, improvement of pharmaceutical effect of the ginsenoside CK is still needed. In our study, we performed acetylation of ginsenoside CK (CK-3) and investigated the an ...
- DOI:
- 10.1016/j.lfs.2022.120698
- https://doi.org/10.1016/j.lfs.2022.120698
- Author:
- Li, Y.L.; Gan, G.P.; Zhang, H.Z.; Wu, H.Z.; Li, C.L.; Huang, Y.P.; Liu, Y.W.; Liu, J.W.
- Source:
- Journal of ethnopharmacology 2007 v.113 no.1 pp. 115-124
- ISSN:
- 0378-8741
- Subject:
- Smilax; medicinal plants; rhizomes; chemical constituents of plants; kaempferol; glucosides; quantitative analysis; plant extracts; bioassays; human cell lines; antineoplastic agents; cytotoxicity; ethnobotany; Oriental traditional medicine; herbal medicines; China
- Abstract:
- ... The anticancer activity of eight crude extracts of Smilax china L. rhizome (SCR) against HeLa cells was assessed by MTT assay and clonogenic assay, the fraction rich in flavonoids had show good activity against HeLa cells. A bioassay-guided separation on this extract lead to the detection of kaempferol-7-O-β-d-glucoside (KG), which belongs to flavonoid glycoside, displayed marked anticancer activi ...
- DOI:
- 10.1016/j.jep.2007.05.016
- https://doi.org/10.1016/j.jep.2007.05.016
- Author:
- Yumeng Wang; Haixia Huang; Sheng Yao; Guiling Li; Congjian Xu; Yang Ye; Suiqi Gui
- Source:
- Journal of ethnopharmacology 2019 v.241 pp. 111980
- ISSN:
- 0378-8741
- Subject:
- CD8-positive T-lymphocytes; Oriental traditional medicine; Pinellia; Western blotting; blood serum; cytotoxicity; dendritic cells; drugs; drying; enzyme-linked immunosorbent assay; flow cytometry; gene expression regulation; immunity; in vitro studies; in vivo studies; interferon-gamma; interleukin-12; lymph nodes; major histocompatibility complex; mice; models; non-specific protein-tyrosine kinase; secretion; spleen; tumor necrosis factor-alpha
- Abstract:
- ... Pinellia pedatisecta Schott (PPS)is a traditional Chinese medicine functioning as reducing swelling and drying dampness. Pinellia pedatisecta Schott extract (PE) has been confirmed to suppress cervical tumor growth and modulate the antitumor CD4+T helper immunity towards Th1.To explore the roles of PE in modulating tumor-associated dendritic cell (TADC) activation and function.For in vivo studies, ...
- DOI:
- 10.1016/j.jep.2019.111980
- https://doi.org/10.1016/j.jep.2019.111980
- Author:
- Wei CHEN; Xiao-Hua LUO; Zhuo WANG; Ying-Ying ZHANG; Li-Ping LIU; Hong-Bing WANG
- Source:
- Chinese journal of natural medicines 2015 v.13 no.7 pp. 550-553
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; Stellera chamaejasme; chemical composition; chromatography; cytotoxicity; flavones; glucosides; human cell lines; humans; inhibitory concentration 50; neoplasm cells; roots; spectral analysis
- Abstract:
- ... The present study investigated the chemical constituents of the roots of Stellera chamaejasme (Thymelaeaceae). One new biflavone glucoside (1), along with other thirteen known compounds (2-14), was isolated by repeated column chromatographic methods and their structures were elucidated on the basis of spectral analyses. The cytotoxic activities of selected compounds were evaluated against four hum ...
- DOI:
- 10.1016/S1875-5364(15)30050-9
- https://doi.org/10.1016/S1875-5364(15)30050-9
- Author:
- Ran XU; Hai-Qin XIE; Lu-Lu DENG; Jian-Xin ZHANG; Fu-Mei YANG; Jian-Hua LIU; Xiao-Jiang HAO; Yuan-Hu ZHANG
- Source:
- Chinese journal of natural medicines 2014 v.12 no.8 pp. 623-627
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; bufadienolides; cell lines; chromatography; cytotoxicity; inhibitory concentration 50; neoplasm cells; spectroscopy
- Abstract:
- ... To study the bufadienolides in the Chinese traditional drug “Ch'an Su” and their cytotoxic activity.Various chromatographic techniques were used to isolate the constituents, and their structures were elucidated through physical and spectroscopic data.Twenty compounds were isolated, and eighteen were evaluated in vitro for their cytotoxic activity against A-549 and K-562 cells.Compound 1 (bufalin 3 ...
- DOI:
- 10.1016/S1875-5364(14)60095-9
- https://doi.org/10.1016/S1875-5364(14)60095-9
- Author:
- Sun, Dong-Dong; Dong, Wei-Wei; Zhang, Han-Qing; Huang, Xian-Feng
- Source:
- Chemistry of natural compounds 2010 v.46 no.2 pp. 180-183
- ISSN:
- 0009-3130
- Subject:
- Isatis tinctoria; Oriental traditional medicine; cytotoxicity; lipids; medicinal plants; roots; structure-activity relationships
- Abstract:
- ... In addition to two ceramides 1-O-β-D-glucopyranosyl-(2S,3R)-N-(2'-hydroxyhexadecanoyl)-octadeca-4E,8Esphingenine (2) and (2S,3S,4R)-N-(2'-hydroxytetracosanoyl)-octadecasphingenine (3), which separated for the first time, a new ceramide 1-O-β-D-glucopyranosyl-(2S,3R)-N-(2'-hydroxyhexacosanoyl)octadecasphingenine (1) was isolated from the traditional Chinese medicinal herb Isatis indigotica. Their c ...
- DOI:
- 10.1007/s10600-010-9562-0
- https://doi.org/10.1007/s10600-010-9562-0
- Author:
- Shang-Jun Yang; Qing-Qiang Yao; Ye-Na Li; Xiao-Xiao Chen; Shu-Xiang Cui; Shao-Yan Bai; Feng-Ling Wang
- Source:
- Journal of Asian natural products research 2012 v.14 no.1 pp. 76-79
- ISSN:
- 1477-2213
- Subject:
- Oriental traditional medicine; anticarcinogenic activity; chromatography; cytotoxicity; hydrolysis; neoplasm cells; nuclear magnetic resonance spectroscopy; roots; spectral analysis
- Abstract:
- ... A new chromone polymorchromone B was isolated and characterized from the roots of Angelicapolymorpha Maxim, a commonly used traditional Chinese medicine. On the basis of spectroscopic analysis, including IR, HR-ESI-MS, 1D and 2D NMR spectral data, and hydrolysis followed by chromatographic analysis, the structure of the new chromone was elucidated as 5-hydroxy-2-[(angeloyloxy)methyl]-2′-(dimethyl) ...
- DOI:
- 10.1080/10286020.2011.631181
- https://doi.org/10.1080/10286020.2011.631181
- Author:
- Li SHEN; Qian LUO; Zhi-Ping SHEN; Ling-Yu LI; Xiao-Jun ZHANG; Zhong-Qi WEI; Yi FU; Yong-Chun SONG; Ren-Xiang TAN
- Source:
- Chinese journal of natural medicines 2014 v.12 no.7 pp. 512-516
- ISSN:
- 1875-5364
- Subject:
- Diaporthe; Oriental traditional medicine; Vatica; chemical composition; cytotoxicity; endophytes; ergosterol; fluorouracil; gel chromatography; high performance liquid chromatography; human cell lines; humans; inhibitory concentration 50; niacin; nuclear magnetic resonance spectroscopy; spectral analysis
- Abstract:
- ... To study the chemical constituents of the solid culture of the endophyte Phomopsis sp. IFB-E060 in Vatica mangachapoi.Isolation and purification were performed through silica gel column chromatography, gel filtration over Sephadex LH-20, ODS column chromatography, and HPLC. Structures of the isolated compounds were elucidated by a combination of spectroscopic analyses (UV, CD, IR, MS, 1D, and 2D N ...
- DOI:
- 10.1016/S1875-5364(14)60080-7
- https://doi.org/10.1016/S1875-5364(14)60080-7
- Author:
- Chen, J.J.; Huang, S.Y.; Duh, C.Y.; Chen, I.S.; Wang, T.C.; Fang, H.Y.
- Source:
- Planta medica 2006 v.72 no.10 pp. 935-938
- ISSN:
- 0032-0943
- Subject:
- Talipariti tiliaceum; humans; phytochemicals; cytotoxicity; anticarcinogenic activity; amides; Oriental traditional medicine; mice; cultured cells; coumarins; spectral analysis; chemical structure; stereochemistry; Hibiscus; Taiwan
- DOI:
- 10.1055/s-2006-931604
- PubMed:
- 16732539
- https://doi.org/10.1055/s-2006-931604
- Author:
- Dan LIU; Wei QU; Ling ZHAO; Fu-Qin GUAN; Jing-Yu LIANG
- Source:
- Chinese journal of natural medicines 2014 v.12 no.2 pp. 139-141
- ISSN:
- 1875-5364
- Subject:
- Alpinia officinarum; Oriental traditional medicine; biochemical pathways; cell lines; chemical composition; chemical reactions; chromatography; cytotoxicity; humans; inhibitory concentration 50; rhizomes; spectral analysis
- Abstract:
- ... To study the chemical constituents of the rhizomes of Alpinia officinarum Hance.Compounds were isolated by repeated column chromatography, and their structures were elucidated on the basis of spectral analysis. The cytotoxic activities of these compounds were evaluated with the T98G and B16F10 cell lines by the MTT assay.A dimeric diarylheptanoid, named alpinin B (1), along with three known diaryl ...
- DOI:
- 10.1016/S1875-5364(14)60022-4
- https://doi.org/10.1016/S1875-5364(14)60022-4
- Author:
- Ying-Hui Dai; An-Dong Wang; Yu-Lin Chen; Ming-Yu Xia; Xin-Yi Shao; Dong-Chun Liu; Dong Wang
- Source:
- Journal of Asian natural products research 2018 v.20 no.6 pp. 581-585
- ISSN:
- 1477-2213
- Subject:
- Oriental traditional medicine; adenocarcinoma; cytotoxicity; epithelial cells; fluorouracil; human cell lines; indole alkaloids; lungs; spectral analysis; water solubility
- Abstract:
- ... A new indole alkaloid N′-formylserotonin (1), along with five known indole alkaloids N′-methylserotonin (2), 5-hydroxy-1H-indole-3-carbaldehyde (3), N-acetylserotonin (4), 6-hydroxy-1-oxo-3,4-dihydro-β-carboline (5), and bufoserotoin C (6), were isolated from the water extract of traditional Chinese medicine Chansu. Their structures were elucidated on the basis of spectral analyses. The cytotoxici ...
- DOI:
- 10.1080/10286020.2017.1339697
- https://doi.org/10.1080/10286020.2017.1339697
- Author:
- Jie Zhao; Jiao Wu; Fu-lin Yan
- Source:
- Natural product research 2014 v.28 no.20 pp. 1669-1673
- ISSN:
- 1478-6427
- Subject:
- Homalomena; Oriental traditional medicine; adenocarcinoma; chemical composition; cytotoxicity; ethyl acetate; humans; mass spectrometry; nuclear magnetic resonance spectroscopy; rhizomes
- Abstract:
- ... Chemical constituents of EtOAc extract from the rhizomes of traditional Chinese medicine Qian-nian-jian (Homalomena occulta) have been studied, a new sesquiterpenoid, named euadesma-4-ene-1β,15-diol (1), and four related known compounds, polydactin B (2), oplodiol (3), 1β,4β,7α-trihydroxyeudesmane (4), and (–)1β,4β,6α-trihydroxy-eudesmane (5), were isolated. Their structures were elucidated using ...
- DOI:
- 10.1080/14786419.2014.934238
- https://doi.org/10.1080/14786419.2014.934238
- Author:
- Kui-Wu Wang; Sheng-Nan Yan; Ting-Ting Zhang; Hai-Jiang Zhang; Bin Wu; Hong Wang
- Source:
- Natural product research 2021 v.35 no.6 pp. 945-950
- ISSN:
- 1478-6427
- Subject:
- Oriental traditional medicine; Premna; apigenin; chemical analysis; chemical structure; cytotoxicity; glycosides; medicinal plants; neoplasm cells; research; China
- Abstract:
- ... Premna fulva Craib, locally known as “Zhangu” in China, is a kind of traditional medicinal plant. A phytochemical investigation on this plant led to the isolation of a novel flavonoid glycoside along with three known analogues. The chemical structure of the new compound was determined by spectral and chemical analysis as apigenin 8-C-β-D-xylopyranoside (1). Compound 1 showed weak inhibitory activi ...
- DOI:
- 10.1080/14786419.2019.1613393
- https://doi.org/10.1080/14786419.2019.1613393
- Author:
- Qing Yang; Yalin Yin; Guojun Yu; Yanxia Jin; Xiangdong Ye; Alok Shrestha; Wei Liu; Wenhui Yu; Hui Sun
- Source:
- International journal of biological macromolecules 2015 v.80 pp. 385-391
- ISSN:
- 0141-8130
- Subject:
- Cordyceps militaris; Oriental traditional medicine; animal models; antineoplastic activity; breast neoplasms; carcinoma; chromatography; circular dichroism spectroscopy; cytotoxicity; databases; fruiting bodies; immunomodulation; interleukin-1beta; interleukin-6; lung neoplasms; macrophages; medicinal fungi; messenger RNA; metastasis; mice; neoplasm cells; transcription (genetics); tumor necrosis factor-alpha
- Abstract:
- ... Cordyceps militaris is a famous fungus used in traditional Chinese medicine for nearly one thousand years. And its fruiting body is known to possess anticancer and immunomodulatory activities. This study describes the isolation, characterization, and test of antitumor activity of a C. militaris protein, called here as “C. militaris immunoregulatory protein” (CMIP). CMIP was purified through a thre ...
- DOI:
- 10.1016/j.ijbiomac.2015.06.050
- https://doi.org/10.1016/j.ijbiomac.2015.06.050
- Author:
- Jie ZHANG; Chuan-Xi WANG; Xiao-Jun SONG; Shuang LI; Huan ZHAO; Guo-Dong CHEN; Dan HU; Hao GAO; Xin-Sheng YAO
- Source:
- Chinese journal of natural medicines 2019 v.17 no.12 pp. 906-911
- ISSN:
- 1875-5364
- Subject:
- Aspergillus niger; Candida albicans; Escherichia coli; Oriental traditional medicine; Picrasma quassioides; Staphylococcus; acetylcholinesterase; antimicrobial properties; bacteria; cytotoxicity; enzyme inhibition; fungi; neoplasm cells; stems; triterpenoids
- Abstract:
- ... A pair of new tirucallane triterpenoid epimers, picraquassins M and N (1> and 2), were isolated from the stems of Picrasma quassioides (D. Don) Benn. Their structures were determined based on comprehensive spectroscopic and X-ray crystallographic analyses. In addition, their AChE inhibitory activity, cytotoxicity against five human tumour cell lines (SW480, MCF-7, HepG2, Hela, and PANC-1), and ant ...
- DOI:
- 10.1016/S1875-5364(19)30111-6
- https://doi.org/10.1016/S1875-5364(19)30111-6
- Author:
- Liang Wang; Wei Chen; Mingming Li; Feng Zhang; Kaixian Chen; Wansheng Chen
- Source:
- Journal of ethnopharmacology 2020 v.254 pp. 112260
- ISSN:
- 0378-8741
- Subject:
- Internet; Oriental traditional medicine; Scutellaria barbata; active ingredients; antineoplastic activity; apigenin; cytotoxicity; databases; diterpenoids; hepatoprotective effect; naringenin; neoplasm cells; neoplasms; plant extracts; quality control; systematic review; therapeutics; China; South Korea
- Abstract:
- ... Scutellaria barbata D. Don (S. barbata) is a well-known perennial herb that is used in traditional Chinese and Korean medicine. In China, it is known as Ban Zhi Lian, while in Korea, it is known as Banjiryun. In the Traditional Chinese Medicine (TCM) system, S. barbata has heat-clearing and detoxifying properties (Qingre Jiedu in Chinese).To provide a systematic review on current multifaceted unde ...
- DOI:
- 10.1016/j.jep.2019.112260
- https://doi.org/10.1016/j.jep.2019.112260
26. A review of the traditional uses, phytochemistry and biological activities of the Melastoma genus
- Author:
- Wen-Jun Zheng; Ying-Shan Ren; Miao-Li Wu; Ya-Ling Yang; Yi Fan; Xiu-Hong Piao; Yue-Wei Ge; Shu-Mei Wang
- Source:
- Journal of ethnopharmacology 2021 v.264 pp. 113322
- ISSN:
- 0378-8741
- Subject:
- Melastoma; Oriental traditional medicine; anticoagulants; antioxidants; chemical composition; cytotoxicity; databases; diarrhea; flavonoids; hemorrhage; herbal medicines; herbs; human diseases; medicinal plants; medicinal properties; neoplasms; phenylpropanoids; research planning; steroids; surveys; tannins; terpenoids; Pacific Ocean Islands; South Asia
- Abstract:
- ... The genus Melastoma consists of approximately 100 species distributed widely in tropical and subtropical countries, and Melastoma species are often used for medicinal purposes, such as treatment for bleeding, diarrhea, diabetes, and gynecological tumors by local people, mostly in Southeast Asian countries.Aim of the review: The present review summarizes the traditional uses, phytochemistry and pha ...
- DOI:
- 10.1016/j.jep.2020.113322
- https://doi.org/10.1016/j.jep.2020.113322
- Author:
- Chen, Muwan; Feng, Wenzhou; Cao, Hui; Zou, Lijin; Chen, Chungui; Baatrup, Anette; Nielsen, Anne Bay; Li, Haisheng; Kassem, Moustapha; Zou, Xuenong; Bünger, Cody
- Source:
- Journal of ethnopharmacology 2009 v.125 no.1 pp. 75-82
- ISSN:
- 0378-8741
- Subject:
- osteocalcin; animal proteins; Oriental traditional medicine; osteoblasts; osteopontin; bone mineralization; inhibitory concentration 50; dose response; biomarkers; herbal medicines; human cell lines; cytotoxicity; stem cells; enzyme activity; cell proliferation; viability; reverse transcriptase polymerase chain reaction; dosage; alkaline phosphatase
- Abstract:
- ... Aim of the study: To investigate the effects of a traditional Chinese medicine (TCM) formula extract, named as ZD-I, on the proliferation and osteogenic differentiation of human mesenchymal stem cells (hMSCs) in vitro. Materials and methods: When hMSCs cultivated in the basal medium with ZD-I, cell viability was assessed by MTT assay and cellular proliferation was assessed by SYBR green I assay. T ...
- DOI:
- 10.1016/j.jep.2009.06.013
- PubMed:
- 19549563
- https://doi.org/10.1016/j.jep.2009.06.013
- Author:
- Shang, X.Y.; Li, C.; Zhang, C.Z.; Yang, Y.C.; Shi, J.G.
- Source:
- Phytochemistry 2006 v.67 no.5 pp. 511-515
- ISSN:
- 0031-9422
- Subject:
- humans; cytotoxicity; lipid peroxidation; Meconopsis; medicinal plants; chemical structure; glucosides; acetylation; isorhamnetin; spectral analysis; cultured cells; liver microsomes; antioxidant activity; quercetin; Oriental traditional medicine; rats; China
- Abstract:
- ... Four acetylated flavonol diglucosides, quercetin 3-O-[2'''-O-acetyl-β-D-glucopyranosyl-(1 to 6)-β-D-glucopyranoside] (1), quercetin 3-O-[2''',6'''-O-diacetyl-β-D-glucopyranosyl-(1 to 6)-β-D-glucopyranoside] (2), isorhamnetin 3-O-[2'''-O-acetyl-β-D-glucopyranosyl-(1 to 6)-β-D-glucopyranoside] (3), and quercetin 3-O-[2'''-O-acetyl-α-L-arabinopyranosyl-(1 to 6)-β-D-glucopyranoside] (4), together with ...
- DOI:
- 10.1016/j.phytochem.2005.12.002
- PubMed:
- 16412484
- https://doi.org/10.1016/j.phytochem.2005.12.002
- Author:
- Tingting Fang; Zhiying Zhao; Feifei Yuan; Mingyan He; Jialei Sun; Mengzhou Guo; Peixin Huang; Biwei Yang; Jinglin Xia
- Source:
- Journal of ethnopharmacology 2020 v.251 pp. 112529
- ISSN:
- 0378-8741
- Subject:
- Actinidia chinensis; Oriental traditional medicine; Western blotting; antineoplastic activity; cell lines; cytotoxicity; genes; hepatoma; messenger RNA; metastasis; mitogen-activated protein kinase; patients; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; root extracts; signal transduction; transcription factors
- Abstract:
- ... Many studies have confirmed that traditional Chinese herbs exert potential anti-tumor effects. Actinidia Chinensis Planch root has been used as a traditional Chinese medicine (TCM) for thousands of years. However, the mechanism of anti-tumor effects of Actinidia Chinensis Planch root has not been clearly clarified.To explore the molecular biological mechanisms underlying the inhibitory effect of A ...
- DOI:
- 10.1016/j.jep.2019.112529
- https://doi.org/10.1016/j.jep.2019.112529
- Author:
- Tingting Fang; Yuan Fang; Xiaojing Xu; Mingyan He; Zhiying Zhao; Peixin Huang; Feifei Yuan; Mengzhou Guo; Biwei Yang; Jinglin Xia
- Source:
- Journal of ethnopharmacology 2019 v.231 pp. 474-485
- ISSN:
- 0378-8741
- Subject:
- Actinidia chinensis; Oriental traditional medicine; animal models; antineoplastic activity; apoptosis; cell proliferation; cell viability; cytotoxicity; diuresis; gene expression; gene expression regulation; genes; hemostasis; hepatoma; herbs; messenger RNA; metastasis; patients; prognosis; quantitative polymerase chain reaction
- Abstract:
- ... Numerous studies have demonstrated the potent anticancer activity of various Chinese herbs. Actinidia chinensis Planch root (acRoots), a traditional Chinese medicine, functions as an antitumor and detoxifying agent and plays a role in diuresis and hemostasis. Treatment with acRoots confers strong inhibition of tumor growth in various forms of cancer. Here, we evaluated the anticancer activity and ...
- DOI:
- 10.1016/j.jep.2018.11.014
- https://doi.org/10.1016/j.jep.2018.11.014
- Author:
- Li-Xing FENG; Peng SUN; Tian MI; Miao LIU; Wang LIU; Si YAO; Yi-Min CAO; Xiao-Lu YU; Wan-Ying WU; Bao-Hong JIANG; Min YANG; De-An GUO; Xuan LIU
- Source:
- Chinese journal of natural medicines 2016 v.14 no.11 pp. 856-864
- ISSN:
- 1875-5364
- Subject:
- Arisaema; Oriental traditional medicine; agglutinins; antineoplastic activity; apoptosis; autophagy; caspase-3; caspase-9; cell cycle checkpoints; cytotoxicity; humans; hydrophobic interaction chromatography; inflammation; interphase; lung neoplasms; medicinal plants; neoplasm cells; organelles; patients; seizures; staining
- Abstract:
- ... Arisaema heterophyllum Blume is one of the three medicinal plants known as traditional Chinese medicine Rhizoma Arisaematis (RA). RA has been popularly used to treat patients with convulsions, inflammation, and cancer for a long time. However, the underlying mechanisms for RA effects are still unclear. The present study was designed to determine the cytotoxicity of agglutinin isolated from Arisema ...
- DOI:
- 10.1016/S1875-5364(16)30102-9
- https://doi.org/10.1016/S1875-5364(16)30102-9
- Author:
- Xu, Y.K.; Yang, S.P.; Liao, S.G.; Zhang, H.; Lin, L.P.; Ding, J.; Yue, J.M.
- Source:
- Journal of natural products 2006 v.69 no.9 pp. 1347-1350
- ISSN:
- 0163-3864
- Subject:
- Gelsemium; medicinal plants; Oriental traditional medicine; Loganiaceae; alkaloids; chemical structure; spectral analysis; cytotoxicity; anticarcinogenic activity; cultured cells; humans; China
- DOI:
- 10.1021/np060156y
- PubMed:
- 16989532
- https://doi.org/10.1021/np060156y
- Author:
- Xueli Tong; Min Li; Di Li; Chunqin Lao; Jingmian Chen; Weijie Xu; Junxi Du; Meijiao Zhang; Xiangcai Yang; Jiejing Li
- Source:
- Journal of ethnopharmacology 2021 v.280 pp. 114434
- ISSN:
- 0378-8741
- Subject:
- Aloe vera; Oriental traditional medicine; acute toxicity; adenosine triphosphate; antineoplastic activity; apoptosis; breasts; chronic toxicity; constipation; cytotoxicity; gels; high performance liquid chromatography; immune system; lung neoplasms; malic acid; metabolism; mitochondria; necrosis; neoplasm cells; oral administration; reactive oxygen species; tandem mass spectrometry; China
- Abstract:
- ... Aloe vera (L.) Burm. f. is a typical traditional Chinese medicine (TCM) collected in the Pharmacopoeia of the People's Republic of China (version 2015). It has been traditionally used for the treatment of constipation, and its potential therapeutic activities have been widely evaluated, including anti-tumor, anti-inflammatory and immune regulatory effects. The wide application of Aloe vera in food ...
- DOI:
- 10.1016/j.jep.2021.114434
- https://doi.org/10.1016/j.jep.2021.114434
- Author:
- De-ming Liu; Dong Yang; Chun-yan Zhou; Jia-si Wu; Guo-lin Zhang; Ping Wang; Fei Wang; Xian-li Meng
- Source:
- Phytomedicine 2020 v.68 pp. 153148
- ISSN:
- 0944-7113
- Subject:
- Oriental traditional medicine; Rheum palmatum; Western blotting; adenosine triphosphate; anthraquinones; apoptosis; autophagy; cell cycle; cytotoxicity; flow cytometry; gene overexpression; glutathione; hepatotoxicity; malondialdehyde; medicinal plants; membrane potential; messenger RNA; mitochondria; mitochondrial DNA; mitochondrial membrane; multiple drug resistance; oxidation; oxidative stress; plasmids; quantitative polymerase chain reaction; reactive oxygen species; reverse transcriptase polymerase chain reaction; small interfering RNA; toxicology
- Abstract:
- ... Aloe-emodin (AE) is among the primary bioactive anthraquinones present in traditional Chinese medicinal plants such as Rheum palmatum L. Multidrug resistance protein 2 (ABCC2/ MRP2) is an important efflux transporter of substances associated with cellular oxidative stress. However, the effects of traditional Chinese medicine on this protein remain unclear.The aim of this research is to study the r ...
- DOI:
- 10.1016/j.phymed.2019.153148
- https://doi.org/10.1016/j.phymed.2019.153148
- Author:
- Maja Šikić Pogačar; Anja Klančnik; Franz Bucar; Tomaž Langerholc; Sonja Smole Možina
- Source:
- Phytotherapy research 2015 v.29 no.10 pp. 1585-1589
- ISSN:
- 0951-418X
- Subject:
- Alpinia; Campylobacter jejuni; Oriental traditional medicine; cell lines; cytotoxicity; diarrhea; epithelium; foods; humans; hydrodistillation; minimum inhibitory concentration; pain; pathogenesis; plant extracts; seeds; small intestine; testing; wastes
- Abstract:
- ... Alpinia katsumadai is used in traditional Chinese medicine for abdominal distention, pain, and diarrhoea. Campylobacter jejuni is the most common cause of bacterial food‐borne diarrhoeal illnesses worldwide. Adhesion to gut epithelium is a prerequisite in its pathogenesis. The antimicrobial, cytotoxic, and anti‐adhesive activities of a chemically characterised extract (SEE) and its residual materi ...
- DOI:
- 10.1002/ptr.5396
- https://doi.org/10.1002/ptr.5396
- Author:
- Jin-Mu Yi; Sarah Shin; No Soo Kim; Ok-Sun Bang
- Source:
- BMC complementary and alternative medicine 2019 v.19 no.1 pp. 339
- ISSN:
- 1472-6882
- Subject:
- Forsythia suspensa; Oriental traditional medicine; adverse effects; alternative medicine; antibodies; antineoplastic activity; antineoplastic agents; colorectal neoplasms; cytotoxicity; dried fruit; drug therapy; fruits; ganglia; herbal medicines; human diseases; immunohistochemistry; liquid chromatography; males; models; neoplasm cells; nerve growth factor; neurites; neuroprotective effect; neurotoxicity; patients; peripheral nervous system diseases; quality of life; staining; viability assays
- Abstract:
- ... BACKGROUND: The dried fruits of Forsythia suspensa has generally been used to clear heat and detoxify in traditional Korean and Chinese medicine. Oxaliplatin is a first-line treatment chemotherapeutic agent for advanced colorectal cancer, but it induces peripheral neuropathy as an adverse side effect affecting the treatment regimen and the patient’s quality of life. The present study was conducted ...
- DOI:
- 10.1186/s12906-019-2761-8
- PubMed:
- 31783843
- PubMed Central:
- PMC6884752
- https://doi.org/10.1186/s12906-019-2761-8
- Author:
- Zhou, Xuefeng; Tang, Lan; Liu, Yonghong
- Source:
- Lipids 2009 v.44 no.8 pp. 759-763
- ISSN:
- 0024-4201
- Subject:
- anti-inflammatory activity; lipopolysaccharides; monocytes; Impatiens; cytotoxicity; medicinal plants; isomers; cerebrosides; cytokines; cultured cells; spectral analysis; Oriental traditional medicine; China
- Abstract:
- ... An isomeric mixture of two cerebrosides, soya-cerebrosides I and II, was isolated from an ethno drug, the rhizomes of Impatiens pritzellii Hook. f. var. hupehensis Hook. f., and their structures were identified by spectroscopic (NMR, MS) analysis. In order to determine the immunomodulatory activities of soya-cerebrosides I and II, the effects of the mixture of cerebrosides (MC) on cytotoxicity of ...
- DOI:
- 10.1007/s11745-009-3321-7
- PubMed:
- 19609788
- https://doi.org/10.1007/s11745-009-3321-7
- Author:
- Bo-Feng Chu; Hang-Ching Lin; Xin-Wen Huang; Han-Yu Huang; Carol P. Wu; Ming-Ching Kao
- Source:
- Journal of functional foods 2016 v.23 pp. 614-627
- ISSN:
- 1756-4646
- Subject:
- Oriental traditional medicine; Wolfiporia cocos; apoptosis; caspase-9; cytochrome c; cytosol; cytotoxicity; dietary supplements; ethanol; functional foods; fungi; ingredients; lung neoplasms; membrane potential; mitochondria; patients; polysaccharides; triterpenoids
- Abstract:
- ... Poria cocos, a food ingredient and a traditional Chinese medicine, is a fungus commonly used in eastern countries. It exhibits diuretic, anti-inflammatory, immunomodulatory and anti-hyperglycaemic functions. In addition, the polysaccharide and triterpenoid components isolated from P. cocos exhibit anti-tumour effects in a number of cancer cell lines. Here, an extract of P. cocos, designated H287, ...
- DOI:
- 10.1016/j.jff.2016.03.016
- https://doi.org/10.1016/j.jff.2016.03.016
- Author:
- Parul Agarwa; Bhawna Sharma; Amreen Fatima; Sanjay Kumar Jain
- Source:
- Asian Pacific Journal of Tropical Biomedicine 2014 v.4 pp. 245-252
- ISSN:
- 2221-1691
- Subject:
- Ayurvedic medicine; Convolvulus prostratus; Oriental traditional medicine; alkaloids; analgesics; antidepressants; anxiety; central nervous system; cough; coumarins; cytotoxicity; epilepsy; fatty acids; flavanoids; glycosides; liver diseases; medicinal properties; metabolites; pharmacognosy; proteins; research and development; sleep disorders; steroids; stomata; therapeutics; toxicology; tranquilizers
- Abstract:
- ... Convolvulus pluricaulis Choisy (C. pluricaulis) is a perennial herb that seems like morning glory. All parts of the herb are known to possess therapeutic benefits. The plant is used locally in Indian and Chinese medicine to cure various diseases. It is used in Ayurvedic formulation for chronic cough, sleeplessness, epilepsy, hallucinations, anxiety etc. Based on the comprehensive review of plant p ...
- DOI:
- 10.1016/S2221-1691(14)60240-9
- PubMed:
- 25182446
- PubMed Central:
- PMC3868798
- https://doi.org/10.1016/S2221-1691(14)60240-9
- Author:
- Haixia Chen; Zhaoshuai Wang; Li Yang
- Source:
- Natural product research 2012 v.26 no.22 pp. 2112-2116
- ISSN:
- 1478-6427
- Subject:
- Euphorbia helioscopia; Oriental traditional medicine; adenocarcinoma; cytotoxicity; diterpenoids; light scattering; mice; quality control; reversed-phase high performance liquid chromatography; China
- Abstract:
- ... Euphorbia helioscopia L. has been used as a herbal remedy for cancer in mainland China. Euphornin is one of the main bioactive constituents with the maximal content of Euphorbia helioscopia L. A reversed-phase high-performance liquid chromatography method with evaporative light scattering detection (ELSD) was developed for the analysis of euphornin for better quality control of E. helioscopia L. A ...
- DOI:
- 10.1080/14786419.2011.622275
- https://doi.org/10.1080/14786419.2011.622275
- Author:
- Kon-Young Ji; Dong Ho Jung; Bo-Jeong Pyun; Yu Jin Kim; Joo Young Lee; Susanna Choi; Myung-A Jung; Kwang Hoon Song; Taesoo Kim
- Source:
- Phytomedicine 2021 v.93 pp. 153789
- ISSN:
- 0944-7113
- Subject:
- Angelica gigas; Oriental traditional medicine; allergic rhinitis; anemia; blood serum; chemokine CCL26; cytotoxicity; epithelium; histopathology; humans; interleukin-13; interleukin-4; interleukin-5; mice; nose; ovalbumin; secretion; sedatives; splenocytes
- Abstract:
- ... Allergic rhinitis (AR) is a well-documented type 2 helper T (Th2) cell-mediated allergic disease that is accompanied by symptoms such as nasal rubbing, sneezing, itching, and rhinorrhea. Angelica gigas (AG) is traditional oriental medicine, and its dried root is widely used for the treatment of anemia, as a sedative, and as a blood tonic.The effects of AG on allergic diseases including AR are curr ...
- DOI:
- 10.1016/j.phymed.2021.153789
- https://doi.org/10.1016/j.phymed.2021.153789
- Author:
- Sofi Mubashir; Mohd Yousuf Dar; Bashir A. Lone; M. Iqbal Zargar; Wajaht A. Shah
- Source:
- Chinese journal of natural medicines 2014 v.12 no.8 pp. 567-572
- ISSN:
- 1875-5364
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Caltha palustris; Oriental traditional medicine; anthelmintics; antimicrobial properties; antioxidant activity; antioxidants; cell lines; cervix; colon; cytotoxicity; fecal egg count; gastrointestinal nematodes; lethal concentration 50; leukemia; lungs; mortality; plant extracts; sheep; viability; India
- Abstract:
- ... The methanolic extract obtained from the root portion of Caltha palustris var. alba was evaluated for its anthelmintic efficacy against gastrointestinal nematodes of sheep under both in vitro and in vivo conditions using worm motility inhibition (WMI) assay and fecal egg count reduction (FECR) assay, respectively. The extract was subjected to antimicrobial activity using agar-well diffusion method ...
- DOI:
- 10.1016/S1875-5364(14)60087-X
- https://doi.org/10.1016/S1875-5364(14)60087-X
- Author:
- Xin-Ya XU; Dong-Ying WANG; Chuen-Fai KU; Yang ZHAO; Han CHENG; Kang-Lun LIU; Li-Jun RONG; Hong-Jie ZHANG
- Source:
- Chinese journal of natural medicines 2019 v.17 no.12 pp. 945-952
- ISSN:
- 1875-5364
- Subject:
- Human immunodeficiency virus 1; Justicia procumbens; Oriental traditional medicine; acetates; antiretroviral properties; chemical structure; cytotoxicity; inhibitory concentration 50; lignans; nuclear magnetic resonance spectroscopy; spectral analysis
- Abstract:
- ... Twenty-one lignans including three new ones (1, 2 and 13) were isolated from Justicia procumbens. The chemical structures of the new lignans were determined by spectroscopic means including 1D and 2D NMR analysis. These compounds were evaluated for their cytotoxic and anti-HIV activities. The new secoisolariciresinol dimethyl ether acetate (13) exhibited anti-HIV-1 activity with an IC50 value of 5 ...
- DOI:
- 10.1016/S1875-5364(19)30117-7
- https://doi.org/10.1016/S1875-5364(19)30117-7
- Author:
- Su-Yeon OH; Young Hoon KIM; Deok Sung BAE; Byung Hun UM; Cheol-Ho PAN; Chul Young KIM; Hee Ju LEE; Jae Kwon LEE
- Source:
- Bioscience, biotechnology, and biochemistry 2010 v.74 no.2 pp. 285-291
- ISSN:
- 1347-6947
- Subject:
- Oriental traditional medicine; Schisandra chinensis; biotechnology; cytokines; cytotoxicity; fruits; lignans; lipopolysaccharides; macrophages; mice; mitogen-activated protein kinase; nitric oxide; phosphorylation; secretion
- Abstract:
- ... Schiandra chinensis is a well-known Chinese traditional medicine for the treatment of hepatic disease. In this study, we investigated whether the nine major compounds of Schiandra chinensis could be applied to suppress lipopolysaccharide (LPS)-induced inflammatory responses in murine macrophages (Raw 264.7 cells). Among the nine lignans, three, gomisin J, gomisin N, and schisandrin C, were found t ...
- DOI:
- 10.1271/bbb.90597
- https://doi.org/10.1271/bbb.90597
- Author:
- Singh Ashok K.; Jiang Yin; Gupta Shveta; Younus Mohamod; Ramzan Mohamod
- Source:
- Journal of medicinal food 2013 v.16 no.10 pp. 899-911
- ISSN:
- 1557-7600
- Subject:
- Ayurvedic medicine; Oriental traditional medicine; active ingredients; adverse effects; animal models; apoptosis; bioavailability; blood; brain; clinical trials; curcumin; cytotoxicity; inflammation; lactic acid; lipopolysaccharides; nanogold; nanoparticles; rats; renal function
- Abstract:
- ... Puerarin (PU) and curcumin (CU), used commonly in traditional Chinese medicine and Ayurveda, have been shown to possess potent anti-inflammatory, anti-oxidation, and neuro-protective properties. Despite the experimental success of CU and PU in in vitro and animal models, their effectiveness has not yet been demonstrated in clinical trials, possibly because of their poor bioavailability. We hypothe ...
- DOI:
- 10.1089/jmf.2012.0049
- https://doi.org/10.1089/jmf.2012.0049
- Author:
- Lu CHEN; Wen-Ling WANG; Teng-Fei SONG; Xin XIE; Xue-Wei YE; Ying LIANG; Hao-Cai HUANG; Shi-Lun YAN; Xiao-Yuan LIAN; Zhi-Zhen ZHANG
- Source:
- Chinese journal of natural medicines 2017 v.15 no.8 pp. 576-583
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; Tripolium; apoptosis; cell cycle; colorectal neoplasms; cytotoxicity; halophytes; humans; neoplasm cells
- Abstract:
- ... Tripolinolate A (TLA) is recently identified as a new compound from a halophyte plant Tripolium vulgare and has been shown to have significant in vitro activity against the proliferation of colorectal cancer and glioma cells. This study was designed to further investigate the effects of TLA on the proliferation of human normal cells, and the apoptosis and cell cycle in colorectal cancer cells, and ...
- DOI:
- 10.1016/S1875-5364(17)30085-7
- https://doi.org/10.1016/S1875-5364(17)30085-7
- Author:
- Chaoqun Wu; Huiqi Huang; Ho-Young Choi; Yuanren Ma; Tongxi Zhou; Yu Peng; Kejian Pang; Guangwen Shu; Xinzhou Yang
- Source:
- Journal of ethnopharmacology 2021 v.269 pp. 113700
- ISSN:
- 0378-8741
- Subject:
- Oriental traditional medicine; antineoplastic activity; apoptosis; cell growth; chromatography; cytotoxicity; dose response; endoplasmic reticulum stress; esophageal neoplasms; flow cytometry; mitochondria; neoplasm progression
- Abstract:
- ... Corilagin (β-1-O-galloyl-3,6-(R)-hexahydroxydiphenoyl-d-glucose) is a tannin isolated from the traditional ethnopharmacological plant Phmllanthi Fructus, which is widely used in not only traditional Chinese medicine but also tropical and subtropical medicine to ameliorate various diseases. This study was designed to isolate the potential anti-esophageal cancer (EC) component corilagin from Phmllan ...
- DOI:
- 10.1016/j.jep.2020.113700
- https://doi.org/10.1016/j.jep.2020.113700
- Author:
- Jung Ju Lee; Kyun Ha Kim; Eun Jeong Kim; Jun-Yong Choi; Sang-Jun Kim; Seung-Il Jeong; Jong-In Kim; Myungsoo Joo
- Source:
- Journal of ethnopharmacology 2018 v.227 pp. 97-104
- ISSN:
- 0378-8741
- Subject:
- Forsythia suspensa; Oriental traditional medicine; anti-inflammatory activity; cytotoxicity; endotoxins; genes; high performance liquid chromatography; inflammation; messenger RNA; reverse transcriptase polymerase chain reaction; transcription factor NF-kappa B; tumor necrosis factor-alpha
- Abstract:
- ... The water extract of Forsythiae Fructus (WFF) is an herbal remedy that is prescribed to treat various inflammatory diseases in traditional Chinese medicine. Although the anti-inflammatory activity of WFF has been reported, the underlying mechanisms for the activity remain unclear. Here, we examined whether the anti-inflammatory activity of WFF is associated with Nrf2, an anti-inflammatory factor, ...
- DOI:
- 10.1016/j.jep.2018.08.027
- https://doi.org/10.1016/j.jep.2018.08.027
- Author:
- Chang, F.R.; Hwang, T.L.; Yang, Y.L.; Li, C.E.; Wu, C.C.; Issa, H.H.; Hsieh, W.B.; Wu, Y.C.
- Source:
- Planta medica 2006 v.72 no.14 pp. 1344-1347
- ISSN:
- 0032-0943
- Subject:
- Polyalthia longifolia; medicinal plants; Oriental traditional medicine; phytochemicals; diterpenoids; chemical structure; spectral analysis; stereochemistry; anti-inflammatory activity; cytotoxicity; anticarcinogenic activity; cultured cells; humans; neutrophils; superoxide anion; Taiwan
- DOI:
- 10.1055/s-2006-951691
- PubMed:
- 17022008
- https://doi.org/10.1055/s-2006-951691
- Author:
- Hyo-Jung Kim; Hae-In Joe; Zhiyun Zhang; Sang Woo Lee; Kyou-Young Lee; Yoon-Bum Kook; Hyo-Jin An
- Source:
- Molecular immunology 2020 v.119 pp. 123-131
- ISSN:
- 0161-5890
- Subject:
- Acalypha australis; Oriental traditional medicine; Western blotting; anti-inflammatory activity; cytotoxicity; enzyme immunoassays; enzyme inhibition; gene expression; inducible nitric oxide synthase; inflammation; interleukin-1beta; interleukin-6; intraperitoneal injection; macrophages; medicinal plants; messenger RNA; methanol; nitric oxide; phosphorylation; plant extracts; protein synthesis; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; septic shock; survival rate; toxicity testing; transcription factor NF-kappa B; tumor necrosis factor-alpha; China
- Abstract:
- ... We evaluated the anti-inflammatory activity of methanol extracts of Chinese medicinal plants from Beijing and determined which extract was the most effective. We found the methanol extract of Acalypha australis L. (AAL) to be the most effective. AAL has been used for clearing heat, toxic material, and hemostasia in Chinese medicine. Although these uses are closely related to inflammation, the anti ...
- DOI:
- 10.1016/j.molimm.2020.01.010
- https://doi.org/10.1016/j.molimm.2020.01.010