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You searched for: Subject term Oriental traditional medicine Remove constraint Subject term: Oriental traditional medicine Subject term humans Remove constraint Subject term: humans
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1. (-)-Xanthienopyran, a new inhibitor of superoxide anion generation by activated neutrophils, and further constituents of the seeds of Xanthium strumarium

Author:
Lee, Chia-Lin; Huang, Po-Ching; Hsieh, Pei-Wen; Hwang, Tsong-Long; Hou, Yu-Yi; Chang, Fang-Rong; Wu, Yang-Chang
Source:
Planta medica 2008 v.74 no.10 pp. 1276-1279
ISSN:
0032-0943
Subject:
cytotoxins; Xanthium strumarium; seeds; humans; cytotoxicity; pyrans; medicinal plants; aldehydes; superoxide anion; neutrophils; cultured cells; spectral analysis; xanthine; chemical structure; Oriental traditional medicine; anticarcinogenic activity
DOI:
10.1055/s-2008-1081295

2. 1β–OH–arenobufagin induces mitochondrial apoptosis in hepatocellular carcinoma through the suppression of mTOR signaling pathway

Author:
Li-Juan Deng; Yu-He Lei; Jing-Yu Quan; Bao-Jing Li; Dong-Mei Zhang; Hai-Yan Tian; Ye Chen; En-Xin Zhang; Lei Chen; Wen-Cai Ye; Wei-Min Ning; Lin-Zhong Yu; Jun-Shan Liu
Source:
Journal of ethnopharmacology 2021 v.266 pp. 113443
ISSN:
0378-8741
Subject:
Bufonidae; Danio rerio; Oriental traditional medicine; apoptosis; cancer therapy; caspase-3; caspase-9; cytotoxicity; drugs; hepatoma; humans; membrane potential; mitochondria; mitochondrial membrane; models; toxicity testing; transfection; xenotransplantation
Abstract:
... Chansu, dried secretions from Bufonidae, has long been used for cancer treatment as a traditional Chinese medicine. In searching for effective anti-hepatoma agents from Chansu, our preliminary drug screening found that a bufadienolide, namely 1β-hydroxyl-arenobufagin (1β–OH–ABF), displays anti-hepatoma activities. However, the anti-hepatoma effects and molecular mechanisms of 1β–OH–ABF have not be ...
DOI:
10.1016/j.jep.2020.113443

3. 2-Hydroxy-3-methylanthraquinone from Hedyotis diffusa Willd induces apoptosis in human leukemic U937 cells through modulation of MAPK pathways

Author:
Nan Wang; Dong-Yang Li; Hui-Yan Niu; Yi Zhang; Ping He; Jia-He Wang
Source:
Archives of pharmacal research 2013 v.36 no.6 pp. 752-758
ISSN:
0253-6269
Subject:
Oldenlandia diffusa; Oriental traditional medicine; anthraquinones; apoptosis; caspase-3; humans; mitogen-activated protein kinase; neoplasm cells
Abstract:
... The herb of Hedyotis diffusa Willd (H. diffusa Willd), an annual herb distributed in northeastern Asia, has been known as a traditional oriental medicine for the treatment of cancer. Recently, Chinese researchers have discovered that two anthraquinones isolated from a water extract of H. diffusa Willd showed apoptosis-inducing effects against cancer cells. However, the cellular and molecular mecha ...
DOI:
10.1007/s12272-013-0096-4

4. 5-Hydroxymethylfurfural protects against ER stress-induced apoptosis in GalN/TNF-α-injured L02 hepatocytes through regulating the PERK-eIF2α signaling pathway

Author:
Ze-Qun JIANG; Yan-Xia MA; Mu-Han LI; Xiu-Qin ZHAN; Xu ZHANG; Ming-Yan WANG
Source:
Chinese journal of natural medicines 2015 v.13 no.12 pp. 896-905
ISSN:
1875-5364
Subject:
Oriental traditional medicine; RNA; Western blotting; apoptosis; calcium; dose response; flow cytometry; fluorescent antibody technique; hepatocytes; humans; hydroxymethylfurfural; liver diseases; mechanism of action; phosphorylation; protective effect; protein kinases; proteins; signal transduction; therapeutics; tumor necrosis factor-alpha; viability; water solubility
Abstract:
... 5-Hydroxymethylfurfural (5-HMF), a water-soluble compound extracted from wine-processed Fructus corni, is a novel hepatic protectant for treating acute liver injury. The present study was designed to investigate the protective effect of 5-HMF in human L02 hepatocytes injured by D-galactosamine (GalN) and tumor necrosis factor-α (TNF-α) in vitro and to explore the underlying mechanisms of action. O ...
DOI:
10.1016/S1875-5364(15)30095-9

5. 8-O-β-D-Glucopyranosyl-2-methylchromone, a new chromone glycoside from the Tibetan medicine plant of Swertia punicea Hemsl

Author:
Lin-Yun Mou; Min Wei; Hai-Yan Wu; Li-Jiao Hu; Jian-Long Li; Gan-Peng Li
Source:
Natural product research 2021 v.36 no.1 pp. 237-245
ISSN:
1478-6427
Subject:
Oriental traditional medicine; Swertia; anti-inflammatory activity; chemotaxonomy; cytotoxicity; glycosides; humans; medicinal plants; metabolites; neoplasm cells; nitric oxide; research; spectral analysis; tetrazolium
Abstract:
... A new chromone glycoside, 8-O-β-D-Glucopyranosyl-2-methylchromone (1), together with eight known compounds (2–9) were isolated from the Tibetan medicine plant of Swertia punicea. All compounds of this plant were reported for the first time. The structures of these metabolites were elucidated by analysis of their HR–ESI–MS, 1D and 2D NMR spectroscopic data and comparison with data reported in the l ...
DOI:
10.1080/14786419.2020.1777123

6. A Chinese herbal decoction prepared from radix astragali and radix angelicae sinensis induces the expression of erythropoietin in cultured Hep3B cells

Author:
Gao, Q.T.; Cheung, J.K.H.; Choi, R.C.Y.; Cheung, A.W.H.; Li, J.; Jiang, Z.Y.; Duan, R.; Zhao, K.J.; Ding, A.W.; Dong, T.T.X.
Source:
Planta medica 2008 v.74 no.4 pp. 392-395
ISSN:
0032-0943
Subject:
Astragalus membranaceus; Angelica sinensis; medicinal plants; medicinal properties; Oriental traditional medicine; cultured cells; humans; erythropoietin; gene expression regulation; mitogen-activated protein kinase; enzyme inhibition
DOI:
10.1055/s-2008-1034322
PubMed:
18484529

7. A Chinese herbal decoction, Danggui Buxue Tang, prepared from Radix Astragali and Radix Angelicae Sinensis stimulates the immune responses

Author:
Gao, Q.T.; Cheung, J.K.H.; Li, J.; Chu, G.K.Y.; Duan, R.; Cheung, A.W.H.; Zhao, K.J.; Dong, T.T.X.; Tsim, K.W.K.
Source:
Planta medica 2006 v.72 no.13 pp. 1227-1231
ISSN:
0032-0943
Subject:
Astragalus; humans; T-lymphocytes; mitogen-activated protein kinase; herbaceous plants; medicinal plants; interleukin-2; macrophages; phagocytosis; cell proliferation; cultured cells; immune response; chemical constituents of plants; protein phosphorylation; Angelica sinensis; Oriental traditional medicine; China
DOI:
10.1055/s-2006-947186
PubMed:
16902872

8. A Comparative Tissue‐specific Metabolite Analysis and Determination of Protodioscin Content in Asparagus Species used in Traditional Chinese Medicine and Ayurveda by use of Laser Microdissection, UHPLC–QTOF/MS and LC–MS/MS

Author:
Yogini Jaiswal; Zhitao Liang; Alan Ho; Hubiao Chen; Zhongzhen Zhao
Source:
Phytochemical analysis 2014 v.25 no.6 pp. 514-528
ISSN:
0958-0344
Subject:
Asparagus racemosus; Ayurvedic medicine; Oriental traditional medicine; biochemical pathways; cortex; drugs; guidelines; humans; markets; metabolites; pith; vascular bundles; China; India
Abstract:
... INTRODUCTION: Asparagus is esteemed in Traditional Chinese Medicine and Ayurveda, and it is commercially one of the most important drugs in the global herbal market. Comparative metabolite profiling of different species would help in determining the similarities and ascertain their validity for being used as substitutes for each other. Laser microdissection (LMD) facilitates identification of meta ...
DOI:
10.1002/pca.2522
PubMed:
24737553

9. A Method for Preparation of an Internal Layer of Artificial Vascular Graft Co-Modified with Salvianolic Acid B and Heparin

Author:
Haizhu Kuang; Yao Wang; Junfeng Hu; Chunsheng Wang; Shuyang Lu; Xiumei Mo
Source:
ACS applied materials & interfaces 2018 v.10 no.23 pp. 19365-19372
ISSN:
1944-8252
Subject:
Oriental traditional medicine; Salvia miltiorrhiza; anticoagulants; biocompatibility; heparin; human umbilical vein endothelial cells; humans; immune response; in vivo studies; rats; salvianolic acid; staining; thrombosis
Abstract:
... Studies have shown that salvianolic acid B (SAB), which is derived from Chinese salvia (Salvia miltiorrhiza), a plant used in traditional Chinese medicine, can promote the proliferation and migration of endothelial cells. The inner layer of an artificial vascular graft was fabricated using the coaxial electrospinning method and was loaded with the anticoagulant heparin and SAB. The release of hepa ...
DOI:
10.1021/acsami.8b02602

10. A NMR-based drug screening strategy for discovering active substances from herbal medicines: Using Radix Polygoni Multiflori as example

Author:
Hong Wan; Yafeng Tian; Haipeng Jiang; Xu Zhang; Xiulian Ju
Source:
Journal of ethnopharmacology 2020 v.254 pp. 112712
ISSN:
0378-8741
Subject:
Oriental traditional medicine; active ingredients; atherosclerosis; clinical trials; diabetes; fatty acid-binding proteins; glycolipids; herbal medicines; humans; hypercholesterolemia; lipid metabolism; new drugs; nuclear magnetic resonance spectroscopy; screening; therapeutics
Abstract:
... Herbal medicines have always been important sources for new drugs. And developing new drugs from traditional herbal medicine is currently still an effective way. However, screening for active substances from herbal medicines extracts has ever been a challenging topic, due to their intrinsic complexity.The herb Radix Polygoni Multiflori has been used as a tonic and an antiaging herb in Traditional ...
DOI:
10.1016/j.jep.2020.112712

11. A Nitrogen-Containing 3-Alkyl-1,4-benzoquinone and a Gomphilactone Derivative from Embelia ribes

Author:
Lin, P.; Li, S.; Wang, S.; Yang, Y.; Shi, J.
Source:
Journal of natural products 2006 v.69 no.11 pp. 1629-1632
ISSN:
0163-3864
Subject:
benzoquinones; lactones; humans; phytochemicals; cytotoxicity; anticarcinogenic activity; medicinal plants; furans; secondary metabolites; cultured cells; spectral analysis; chemical structure; Oriental traditional medicine; Embelia ribes; China
DOI:
10.1021/np060284m
PubMed:
17125236

12. A Strategy for Screening the Lipid-Lowering Components in Alismatis Rhizoma Decoction Based on Spectrum-Effect Analysis

Author:
Xiao-Yan Chang; Jia-Shuo Wu; Fang-Qing Zhang; Zhuang-Zhuang Li; Wei-Yi Jin; Jing-Xun Wang; Wei-Hua Wang; Yue Shi
Source:
Journal of Analytical Methods in Chemistry (Online) 2022 v.2022 pp. -
ISSN:
2090-8873
Subject:
Atractylodes macrocephala; Oriental traditional medicine; hepatoma; humans; hyperlipidemia; lipemic effect; mechanism of action; models; rhizomes
Abstract:
... Alismatis Rhizoma decoction (ARD), comprised of Alisma plantago-aquatica subsp. orientale (Sam.) Sam and Atractylodes macrocephala Koidz. at a ratio of 5 : 2, is a classic traditional Chinese medicine (TCM) formula with successful clinical hypolipidemic effect. This paper aimed to explore the major bioactive compounds and potential mechanism of ARD in the treatment of hyperlipidemia on the basis o ...
DOI:
10.1155/2022/2363242

13. A Yang-promoting Chinese herbal suppository preparation enhances the antioxidant status of red cells in male human subjects

Author:
Mak, D.H.F.; Chiu, P.Y.; Poon, M.K.T.; Ng, T.T.L.; Chung, Y.K.; Lam, B.Y.H.; Du, Y.; Ko, K.M.
Source:
Phytotherapy research 2004 v.18 no.7 pp. 525-530
ISSN:
0951-418X
Subject:
Oriental traditional medicine; herbal medicines; erythrocytes; antioxidant activity; humans; males
DOI:
10.1002/ptr.1476
PubMed:
15305310

14. A fatal diarrhoea outbreak in farm‐raised Deinagkistrodon acutus in China is newly linked to potentially zoonotic Aeromonas hydrophila

Author:
Junqi Liu; Lingfeng Xie; Dun Zhao; Taotao Yang; Yunfei Hu; Zhiliang Sun; Xinglong Yu
Source:
Transboundary and emerging diseases 2019 v.66 no.1 pp. 287-298
ISSN:
1865-1674
Subject:
Aeromonas hydrophila; Oriental traditional medicine; Viperidae; animal husbandry; bacteria; bacterial infections; control methods; diarrhea; emerging diseases; environmental assessment; humans; industry; mice; pathogens; signs and symptoms (animals and humans); snakes; virulence; zoonoses; China
Abstract:
... Deinagkistrodon acutus is a venomous pit viper commonly used in traditional Chinese medicine; farming these snakes has become a major industry. In 2017, an outbreak of fatal diarrhoea among farm‐raised D. acutus in Hunan Province caused the deaths of 5,600 snakes within 3 weeks. We isolated a brand‐new sequence type of Aeromonas hydrophila (ST516) from lesions and confirmed that this bacterium was ...
DOI:
10.1111/tbed.13020

15. A molecular docking study of Rhizoma Atractylodis and Rhizoma Atractylodis Macrocephalae herbal pair with respect to type 2 diabetes mellitus

Author:
Che Chen; Sheng Zhou; Qinggang Meng
Source:
Journal of traditional Chinese medical sciences 2018 v.5 no.2 pp. 185-198
ISSN:
2095-7548
Subject:
Atractylodes lancea; Atractylodes macrocephala; Oriental traditional medicine; bioavailability; blood glucose; computer software; databases; dipeptidyl-peptidase IV; energy; humans; insulin receptors; ligands; noninsulin-dependent diabetes mellitus; pharmacology; rhizomes; surveys
Abstract:
... To investigate the action mechanism of Rhizoma Atractylodis (Atractylodes lancea (Thunb.) Dc.) and Rhizoma Atractylodis Macrocephalae (Atractylodes macrocephala Koidz.), a two-herb ancient traditional Chinese medicine used to treat type 2 diabetes mellitus, using molecular docking.The Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform was searched for compounds in the ...
DOI:
10.1016/j.jtcms.2018.05.004

16. A natural inhibitor from Alisma orientale against human carboxylesterase 2: Kinetics, circular dichroism spectroscopic analysis, and docking simulation

Author:
Jing Yi; Rong Bai; Yue An; Tian-Tian Liu; Jia-Hao Liang; Xiang-Ge Tian; Xiao-Kui Huo; Lei Feng; Jing Ning; Cheng-Peng Sun; Xiao-Chi Ma; Hou-Li Zhang
Source:
International journal of biological macromolecules 2019 v.133 pp. 184-189
ISSN:
0141-8130
Subject:
Alisma orientale; Oriental traditional medicine; carboxylesterase; circular dichroism spectroscopy; computer simulation; humans; hydrolysis; inhibitory concentration 50; nuclear magnetic resonance spectroscopy; spectral analysis; triterpenoids
Abstract:
... As a part of our searching for natural human carboxylesterase 2 (human CES 2) inhibitors from traditional Chinese medicine, we found that the extract of Alisma orientale significantly inhibited human CES 2 in vitro. The investigation on A. orientale led to the isolation of a new protostane-type triterpenoid alismanin I (1). Its structure was determined according to HRESIMS, 1D and 2D NMR spectra. ...
DOI:
10.1016/j.ijbiomac.2019.04.099

17. A new A₄₃₁/cell membrane chromatography and online high performance liquid chromatography/mass spectrometry method for screening epidermal growth factor receptor antagonists from Radix sophorae flavescentis

Author:
Wang, Sicen; Sun, Meng; Zhang, Yanmin; Du, Hui; He, Langchong
Source:
Journal of chromatography 2010 v.1217 no.32 pp. 5246-5252
ISSN:
0021-9673
Subject:
Oriental traditional medicine; antagonists; cell growth; cell membranes; drugs; epidermal growth factor receptors; high performance liquid chromatography; humans; mass spectrometry; medicinal plants; models; neoplasm cells; screening; secretion
Abstract:
... The intracellular kinase domains of epidermal growth factor receptor (EGFR) in some tumor cells such as human epidermal squamous cells (A₄₃₁ cells) are an important target for drug discovery. We have developed a new A₄₃₁/cell membrane chromatography (A₄₃₁/CMC)-online-high performance liquid chromatography/mass spectrometry (HPLC/MS) method for screening EGFR antagonists from medicinal herbs such a ...
DOI:
10.1016/j.chroma.2010.06.037

18. A new biflavone glucoside from the roots of Stellera chamaejasme

Author:
Wei CHEN; Xiao-Hua LUO; Zhuo WANG; Ying-Ying ZHANG; Li-Ping LIU; Hong-Bing WANG
Source:
Chinese journal of natural medicines 2015 v.13 no.7 pp. 550-553
ISSN:
1875-5364
Subject:
Oriental traditional medicine; Stellera chamaejasme; chemical composition; chromatography; cytotoxicity; flavones; glucosides; human cell lines; humans; inhibitory concentration 50; neoplasm cells; roots; spectral analysis
Abstract:
... The present study investigated the chemical constituents of the roots of Stellera chamaejasme (Thymelaeaceae). One new biflavone glucoside (1), along with other thirteen known compounds (2-14), was isolated by repeated column chromatographic methods and their structures were elucidated on the basis of spectral analyses. The cytotoxic activities of selected compounds were evaluated against four hum ...
DOI:
10.1016/S1875-5364(15)30050-9

19. A new cytochalasin from endophytic Phomopsis sp. IFB-E060

Author:
Li SHEN; Qian LUO; Zhi-Ping SHEN; Ling-Yu LI; Xiao-Jun ZHANG; Zhong-Qi WEI; Yi FU; Yong-Chun SONG; Ren-Xiang TAN
Source:
Chinese journal of natural medicines 2014 v.12 no.7 pp. 512-516
ISSN:
1875-5364
Subject:
Diaporthe; Oriental traditional medicine; Vatica; chemical composition; cytotoxicity; endophytes; ergosterol; fluorouracil; gel chromatography; high performance liquid chromatography; human cell lines; humans; inhibitory concentration 50; niacin; nuclear magnetic resonance spectroscopy; spectral analysis
Abstract:
... To study the chemical constituents of the solid culture of the endophyte Phomopsis sp. IFB-E060 in Vatica mangachapoi.Isolation and purification were performed through silica gel column chromatography, gel filtration over Sephadex LH-20, ODS column chromatography, and HPLC. Structures of the isolated compounds were elucidated by a combination of spectroscopic analyses (UV, CD, IR, MS, 1D, and 2D N ...
DOI:
10.1016/S1875-5364(14)60080-7

20. A new cytotoxic amide from the stem wood of Hibiscus tiliaceus

Author:
Chen, J.J.; Huang, S.Y.; Duh, C.Y.; Chen, I.S.; Wang, T.C.; Fang, H.Y.
Source:
Planta medica 2006 v.72 no.10 pp. 935-938
ISSN:
0032-0943
Subject:
Talipariti tiliaceum; humans; phytochemicals; cytotoxicity; anticarcinogenic activity; amides; Oriental traditional medicine; mice; cultured cells; coumarins; spectral analysis; chemical structure; stereochemistry; Hibiscus; Taiwan
DOI:
10.1055/s-2006-931604
PubMed:
16732539

21. A new dimeric diarylheptanoid from the rhizomes of Alpinia officinarum

Author:
Dan LIU; Wei QU; Ling ZHAO; Fu-Qin GUAN; Jing-Yu LIANG
Source:
Chinese journal of natural medicines 2014 v.12 no.2 pp. 139-141
ISSN:
1875-5364
Subject:
Alpinia officinarum; Oriental traditional medicine; biochemical pathways; cell lines; chemical composition; chemical reactions; chromatography; cytotoxicity; humans; inhibitory concentration 50; rhizomes; spectral analysis
Abstract:
... To study the chemical constituents of the rhizomes of Alpinia officinarum Hance.Compounds were isolated by repeated column chromatography, and their structures were elucidated on the basis of spectral analysis. The cytotoxic activities of these compounds were evaluated with the T98G and B16F10 cell lines by the MTT assay.A dimeric diarylheptanoid, named alpinin B (1), along with three known diaryl ...
DOI:
10.1016/S1875-5364(14)60022-4

22. A new sesquiterpenoid from the rhizomes of Homalomena occulta

Author:
Jie Zhao; Jiao Wu; Fu-lin Yan
Source:
Natural product research 2014 v.28 no.20 pp. 1669-1673
ISSN:
1478-6427
Subject:
Homalomena; Oriental traditional medicine; adenocarcinoma; chemical composition; cytotoxicity; ethyl acetate; humans; mass spectrometry; nuclear magnetic resonance spectroscopy; rhizomes
Abstract:
... Chemical constituents of EtOAc extract from the rhizomes of traditional Chinese medicine Qian-nian-jian (Homalomena occulta) have been studied, a new sesquiterpenoid, named euadesma-4-ene-1β,15-diol (1), and four related known compounds, polydactin B (2), oplodiol (3), 1β,4β,7α-trihydroxyeudesmane (4), and (–)1β,4β,6α-trihydroxy-eudesmane (5), were isolated. Their structures were elucidated using ...
DOI:
10.1080/14786419.2014.934238

23. A novel method to analyze hepatotoxic components in Polygonum multiflorum using ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry

Author:
Longfei Lin; Hongmei Lin; Miao Zhang; Boran Ni; Xingbin Yin; Changhai Qu; Jian Ni
Source:
Journal of hazardous materials 2015 v.299 pp. 249-259
ISSN:
0304-3894
Subject:
Oriental traditional medicine; Reynoutria multiflora; adverse effects; alanine transaminase; aspartate transaminase; computer software; emodin; ethanol; hepatocytes; hepatotoxicity; humans; lactate dehydrogenase; liquid chromatography; liver; mass spectrometry; secretion; China
Abstract:
... Polygonum multiflorum, called Heshouwu in China, is a traditional Chinese medicine used to treat various diseases. However, the administration of P. multiflorum (PM) and P. multiflorum Praeparata (PMP) causes numerous adverse effects. This study sought to analyze the toxic components of PM using ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS), an ...
DOI:
10.1016/j.jhazmat.2015.06.014

24. A novel mode of stimulating platelet formation activity in megakaryocytes with peanut skin extract

Author:
Takahiro Sato; Masako Akiyama; Ken-ichi Nakahama; Shujiro Seo; Masamichi Watanabe; Jin Tatsuzaki; Ikuo Morita
Source:
Natural medicines 2018 v.72 no.1 pp. 211-219
ISSN:
1340-3443
Subject:
Arachis hypogaea; DNA; GATA transcription factors; Oriental traditional medicine; acetates; blood platelets; hematopoiesis; hematopoietic stem cells; hemorrhage; humans; liquids; megakaryocytes; messenger RNA; mice; oral administration; peanuts
Abstract:
... We report in this study novel biochemical activities of peanut skin extract (PEXT) on thrombocytopoiesis. Peanut skin, derived from Arachis hypogaea L., is a traditional Chinese medicine that is used to treat chronic hemorrhage. We have shown that oral administration of PEXT increases the peripheral platelet levels in mice. Recently, we reported a liquid culture system that is useful for investiga ...
DOI:
10.1007/s11418-017-1135-0

25. A polysaccharides MDG-1 augments survival in the ischemic heart by inducing S1P release and S1P1 expression

Author:
Shuo Wang; Xiao Lin; Ling-Yi Wang; Ke-Feng Ruan; Yi Feng; Xiao-Yan Li
Source:
International journal of biological macromolecules 2012 v.50 no.3 pp. 734-740
ISSN:
0141-8130
Subject:
Ophiopogon japonicus; Oriental traditional medicine; RNA interference; analytical methods; autocrine signaling; cardiomyocytes; cardiovascular diseases; coronary vessels; endothelial cells; glucose; humans; hypoxia; ischemia; models; oxygen; polysaccharides; protective effect; receptors; signal transduction; sphingosine; transfection
Abstract:
... Ophiopogon japonicus is a traditional Chinese medicine used to treat cardiovascular disease. Recent studies have confirmed the anti-ischemic properties of a water-soluble β-d-fructan (MDG-1) from O. japonicus. The sphingosine 1-phosphate (S1P) signaling pathway is involved in its cytoprotective effects. Herein, we explore the role of the S1P signaling pathway in the anti-ischemic effect of MDG-1 a ...
DOI:
10.1016/j.ijbiomac.2011.12.005

26. A review of the phytochemical, pharmacological, pharmacokinetic, and toxicological evaluation of Quercus Infectoria galls

Author:
Aliya Elham; Miradel Arken; Gulina Kalimanjan; Abdulaziz Arkin; Mubarak Iminjan
Source:
Journal of ethnopharmacology 2021 v.273 pp. 113592
ISSN:
0378-8741
Subject:
Internet; Oriental traditional medicine; Quercus infectoria; Turkey (country); antioxidants; antiparasitic agents; diarrhea; dietary supplements; flavonoids; hemorrhage; humans; metabolites; pharmacokinetics; skin diseases; therapeutics; toxicity; toxicity testing; triterpenoids; Greece; Syria
Abstract:
... Quercus Infectoria galls (QIG) have a long history of use in traditional Chinese medicine and traditional Uyghur medicine for the treatment of diarrhea, hemorrhage, skin disease, and many other human ailments. Medicinal applications of QIG have become increasingly popular in Greece, Asia Minor, Syria, and Iran.The present paper reviewed the ethnopharmacology, phytochemistry, analytical methods, bi ...
DOI:
10.1016/j.jep.2020.113592

27. A review on traditional uses, phytochemistry, pharmacology, pharmacokinetics and toxicology of the genus Peganum

Author:
Shuping Li; Xuemei Cheng; Changhong Wang
Source:
Journal of ethnopharmacology 2017 v.203 pp. 127-162
ISSN:
0378-8741
Subject:
Alzheimer disease; DNA topoisomerase; Internet; Oriental traditional medicine; Parkinson disease; Peganum; alkaloids; amine oxidase (flavin-containing); analytical methods; anticoagulants; antioxidants; asthma; cholinesterase; clinical trials; colic; cough; diabetes; drug interactions; flavonoids; humans; hypertension; jaundice; medicinal properties; metabolites; neoplasms; oils; pharmacokinetics; toxicology; vasodilation; India; Iran
Abstract:
... The plants of the genus Peganum have a long history as a Chinese traditional medicine for the treatment of cough, hypertension, diabetes, asthma, jaundice, colic, lumbago, and many other human ailments. Additionally, the plants can be used as an amulet against evil-eye, dye and so on, which have become increasingly popular in Asia, Iran, Northwest India, and North Africa.The present paper reviewed ...
DOI:
10.1016/j.jep.2017.03.049

28. Abietane Diterpenes from Salvia miltiorrhiza Inhibit the Activation of Hypoxia-Inducible Factor-1

Author:
Dat, N.T.; Jin, X.J.; Lee, J.H.; Lee, D.H.; Hong, Y.S.; Lee, K.; Kim, Y.H.; Lee, J.J.
Source:
Journal of natural products 2007 v.70 no.7 pp. 1093-1097
ISSN:
0163-3864
Subject:
Salvia miltiorrhiza; transcription factors; humans; phytochemicals; medicinal plants; cultured cells; diterpenoids; vascular endothelial growth factors; gene expression regulation; Oriental traditional medicine; anticarcinogenic activity
DOI:
10.1021/np060482d
PubMed:
17583950

29. Absolute configuration of podophyllotoxone and its inhibitory activity against human prostate cancer cells

Author:
Juan LI; Juan FENG; Cheng LUO; Ho-Yung Sung Herman; Ren-Wang JIANG
Source:
Chinese journal of natural medicines 2015 v.13 no.1 pp. 59-64
ISSN:
1875-5364
Subject:
Oriental traditional medicine; X-radiation; dose response; humans; inhibitory concentration 50; molecular models; neoplasm cells; polymerization; prostatic neoplasms; roots; spectral analysis; tubulin
Abstract:
... Podophyllotoxone (1) was isolated from the roots of Dysosma versipellis. The structure was determined by spectroscopic analysis in combination with single-crystal X-ray analysis. The absolute configuration of compound 1 was assigned based on the Flack parameter. It showed significant inhibitory activities against human prostate cancer cells PC3 and DU145 with IC50 values being 14.7 and 20.6 μmol·L ...
DOI:
10.1016/S1875-5364(15)60007-3

30. Absorption properties and mechanism of trolline and veratric acid and their implication to an evaluation of the effective components of the flowers of Trollius chinensis

Author:
Li-Jia LIU; Xiu-Wen WU; Ru-Feng WANG; Yu-Shuai PENG; Xin YANG; Jun-Xiu LIU
Source:
Chinese journal of natural medicines 2014 v.12 no.9 pp. 700-704
ISSN:
1875-5364
Subject:
Oriental traditional medicine; Trollius chinensis; absorption; flowers; human cell lines; humans; models; permeability; pharmacodynamics
Abstract:
... To study the absorption properties and mechanism of two important components, trolline and veratric acid, from the flowers of Trollius chinensis, in order to better understand the contribution of these two compounds to the effectiveness of these flowers.The human Caco-2 cell monolayer model was employed to study the transport of trolline and veratric acid from apical side (AP) to basal side (BL), ...
DOI:
10.1016/S1875-5364(14)60108-4

31. Acetylated flavonol diglucosides from Meconopsis quintuplinervia

Author:
Shang, X.Y.; Li, C.; Zhang, C.Z.; Yang, Y.C.; Shi, J.G.
Source:
Phytochemistry 2006 v.67 no.5 pp. 511-515
ISSN:
0031-9422
Subject:
humans; cytotoxicity; lipid peroxidation; Meconopsis; medicinal plants; chemical structure; glucosides; acetylation; isorhamnetin; spectral analysis; cultured cells; liver microsomes; antioxidant activity; quercetin; Oriental traditional medicine; rats; China
Abstract:
... Four acetylated flavonol diglucosides, quercetin 3-O-[2'''-O-acetyl-β-D-glucopyranosyl-(1 to 6)-β-D-glucopyranoside] (1), quercetin 3-O-[2''',6'''-O-diacetyl-β-D-glucopyranosyl-(1 to 6)-β-D-glucopyranoside] (2), isorhamnetin 3-O-[2'''-O-acetyl-β-D-glucopyranosyl-(1 to 6)-β-D-glucopyranoside] (3), and quercetin 3-O-[2'''-O-acetyl-α-L-arabinopyranosyl-(1 to 6)-β-D-glucopyranoside] (4), together with ...
DOI:
10.1016/j.phytochem.2005.12.002
PubMed:
16412484

32. Activity of several kinds of drugs against Neospora caninum

Author:
Weifeng Qian; Hui Wang; Dan Shan; Bo Li; Jing Liu; Qun Liu
Source:
Parasitology international 2015 v.64 no.6 pp. 597-602
ISSN:
1383-5769
Subject:
inhibitory concentration 50; atrazine; cattle diseases; neosporosis; parasites; diminazene; humans; toltrazuril; cattle; dogs; Neospora caninum; models; Protozoa; neonatal mortality; praziquantel; glyphosate; cyclophosphamide; fibroblasts; curcumin; Oriental traditional medicine
Abstract:
... Neosporosis caused by Neospora caninum is a serious disease in cattle and dogs worldwide. It is the major cause of abortion and neonatal mortality in cattle. In this study, we evaluated the anti-N. caninum activity of Chinese medicine extracts (curcumin, artemether), herbicides (atrazine, glyphosate), anticoccidiosis drugs (toltrazuril and ponazuril), cyclophosphamide, diminazene aceturate and pra ...
DOI:
10.1016/j.parint.2015.08.002

33. Agglutinin isolated from Arisema heterophyllum Blume induces apoptosis and autophagy in A549 cells through inhibiting PI3K/Akt pathway and inducing ER stress

Author:
Li-Xing FENG; Peng SUN; Tian MI; Miao LIU; Wang LIU; Si YAO; Yi-Min CAO; Xiao-Lu YU; Wan-Ying WU; Bao-Hong JIANG; Min YANG; De-An GUO; Xuan LIU
Source:
Chinese journal of natural medicines 2016 v.14 no.11 pp. 856-864
ISSN:
1875-5364
Subject:
Arisaema; Oriental traditional medicine; agglutinins; antineoplastic activity; apoptosis; autophagy; caspase-3; caspase-9; cell cycle checkpoints; cytotoxicity; humans; hydrophobic interaction chromatography; inflammation; interphase; lung neoplasms; medicinal plants; neoplasm cells; organelles; patients; seizures; staining
Abstract:
... Arisaema heterophyllum Blume is one of the three medicinal plants known as traditional Chinese medicine Rhizoma Arisaematis (RA). RA has been popularly used to treat patients with convulsions, inflammation, and cancer for a long time. However, the underlying mechanisms for RA effects are still unclear. The present study was designed to determine the cytotoxicity of agglutinin isolated from Arisema ...
DOI:
10.1016/S1875-5364(16)30102-9

34. Aidi injection induces apoptosis of hepatocellular carcinoma cells through the mitochondrial pathway

Author:
Hai-Yue Lan; Pei An; Qiu-Ping Liu; Yu-Ying Chen; Yuan-Yuan Yu; Xin Luan; Jian-Yuan Tang; Hong Zhang
Source:
Journal of ethnopharmacology 2021 v.274 pp. 114073
ISSN:
0378-8741
Subject:
4',6-diamidino-2-phenylindole; Oriental traditional medicine; apoptosis; astragalosides; cantharidin; carcinoma; flow cytometry; ginsenosides; growth retardation; hepatoma; humans; mechanism of action; membrane potential; mitochondria; mitochondrial membrane; mortality; sequence analysis; signal transduction; viability
Abstract:
... The incidence and mortality rates of hepatocellular carcinoma are very high all over the world, which seriously threatens human life and health. Aidi injection as a Chinese medicine preparation has a positive curative effect on hepatocellular carcinoma, but its mechanism remains unclear.The purpose of this study is to evaluate the anti-hepatocellular carcinoma effects of Aidi injection and explore ...
DOI:
10.1016/j.jep.2021.114073

35. Akkermansia muciniphila: a promising target for the therapy of metabolic syndrome and related diseases

Author:
Ji-Chao ZHOU; Xiao-Wei ZHANG
Source:
Chinese journal of natural medicines 2019 v.17 no.11 pp. 835-841
ISSN:
1875-5364
Subject:
Oriental traditional medicine; Verrucomicrobia; bacteria; drugs; feces; humans; intestinal microorganisms; intestines; metabolic diseases; metabolic syndrome; metabolism; metagenomics; mucins; probiotics; therapeutics
Abstract:
... The probiotic Akkermansia muciniphila (A. muciniphila) is an intestinal bacterium that was first identified in human feces in 2004. Its specialization in mucin degradation makes it a key microorganism that maintains intestinal mucosal barrier function. As an unique representative strain of the phylum Verrucomicrobia that can be cultured in vitro, A. muciniphila is much easier to detect by metageno ...
DOI:
10.1016/S1875-5364(19)30101-3

36. Alisol B 23-acetate from the rhizomes of Alisma orientale is a natural agonist of the human pregnane X receptor

Author:
Yuichiro Kanno; Tomofumi Yatsu; Naoya Yamashita; Shuai Zhao; Wei Li; Miyuki Imai; Manami Kashima; Yoshio Inouye; Kiyomitsu Nemoto; Kazuo Koike
Source:
Phytomedicine 2017 v.26 pp. 22-27
ISSN:
0944-7113
Subject:
Alisma orientale; Alisols; Oriental traditional medicine; abscisic acid; active ingredients; agonists; drugs; fractionation; hepatocytes; hepatoma; humans; ligands; luciferase; medicinal plants; messenger RNA; plant extracts; receptors; reporter genes; reverse transcriptase polymerase chain reaction; rhizomes; screening; transcription (genetics); transcriptional activation
Abstract:
... Pregnane X receptor (PXR) is a key regulator of the induction of drug metabolizing enzymes. PXR has been studied for its importance in drug-drug or herb-drug interactions, and it is also a molecular target for the treatment of inflammatory and metabolic diseases.This study aims to determine new natural PXR-ligands from traditional plant medicines.The PXR activation activity was measured by a mamma ...
DOI:
10.1016/j.phymed.2017.01.003

37. Alkaloid extract of Corydalis yanhusuo inhibits angiogenesis via targeting vascular endothelial growth factor receptor signaling

Author:
Li Wan; Yang Zhao; Qun Zhang; Guangyi Gao; Shanlan Zhang; Yong Gao; Xiaofei Chen; Xiaoping Qian
Source:
BMC complementary and alternative medicine 2019 v.19 no.1 pp. 359
ISSN:
1472-6882
Subject:
Corydalis yanhusuo; Oriental traditional medicine; Western blotting; alkaloids; alternative medicine; angiogenesis; chorioallantoic membrane; drugs; endothelial cells; enzyme inhibitors; flowering; fluorescent antibody technique; functional foods; humans; mitogen-activated protein kinase; models; phosphorylation; protein synthesis; signal transduction; staining; tissue repair; toxicity; toxicity testing; vascular endothelial growth factor receptor-2
Abstract:
... BACKGROUND: Corydalis yanhusuo W.T. Wang (YHS) is a well-known Chinese flowering herbal plant commonly used for centuries in functional food and traditional Chinese medicine. In the present study, we have identified and characterized a novel inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2) with low toxicity, alkaloid extract of YHS, which suppressed angiogenesis that plays a fun ...
DOI:
10.1186/s12906-019-2739-6
PubMed:
31823762
PubMed Central:
PMC6905101

38. Alkaloids from Gelsemium elegans

Author:
Xu, Y.K.; Yang, S.P.; Liao, S.G.; Zhang, H.; Lin, L.P.; Ding, J.; Yue, J.M.
Source:
Journal of natural products 2006 v.69 no.9 pp. 1347-1350
ISSN:
0163-3864
Subject:
Gelsemium; medicinal plants; Oriental traditional medicine; Loganiaceae; alkaloids; chemical structure; spectral analysis; cytotoxicity; anticarcinogenic activity; cultured cells; humans; China
DOI:
10.1021/np060156y
PubMed:
16989532

39. Alleviatory effects of Danshen, Salvianolic acid A and Salvianolic acid B on PC12 neuronal cells and Drosophila melanogaster model of Alzheimer's disease

Author:
Florence Hui Ping Tan; Andrew Chung Jie Ting; Ban Guan Leow; Nazalan Najimudin; Nobumoto Watanabe; Ghows Azzam
Source:
Journal of ethnopharmacology 2021 v.279 pp. 114389
ISSN:
0378-8741
Subject:
Alzheimer disease; Drosophila melanogaster; Oriental traditional medicine; Salvia miltiorrhiza; brain; cell death; eyes; humans; longevity; models; neurodegenerative diseases; neurons; pathogenesis; phenotype; salvianolic acid; therapeutics; toxicity; ultra-performance liquid chromatography
Abstract:
... Danshen water extract (DWE), obtained from the Salvia miltiorrhiza Bunge (Family Lamiaceae) root, is usually employed in Chinese traditional medicine as treatment to cardiovascular ailments and cerebrovascular diseases. Intriguingly, the extract was also found to contain vast beneficial properties in Alzheimer's disease (AD) treatment.Alzheimer's disease is the most significant type of neurodegene ...
DOI:
10.1016/j.jep.2021.114389

40. Alopecurone B reverses doxorubicin-resistant human osteosarcoma cell line by inhibiting P-glycoprotein and NF-kappa B signaling

Author:
Yuan-Zheng Xia; Kai Ni; Chao Guo; Chao Zhang; Ya-Di Geng; Zhen-Dong Wang; Lei Yang; Ling-Yi Kong
Source:
Phytomedicine 2015 v.22 pp. 344-351
ISSN:
0944-7113
Subject:
Oriental traditional medicine; P-glycoproteins; Sophora alopecuroides; Western blotting; apoptosis; cell viability; doxorubicin; drug therapy; flavonoids; flow cytometry; humans; multiple drug resistance; osteosarcoma; quantitative polymerase chain reaction; reporter genes; transcription factor NF-kappa B
Abstract:
... Doxorubicin (DOX) was first used in osteosarcoma in the early 1970s as a first-line antineoplastic drug. However, the occurrence of drug resistance in chemotherapeutic treatment has greatly restricted its use. When resistance to DOX treatment occurs, osteosarcoma may become not only resistant to the drug originally administered but also to a wide variety of structurally and mechanistically unrelat ...
DOI:
10.1016/j.phymed.2014.12.011

41. Aloperine induces apoptosis and G2/M cell cycle arrest in hepatocellular carcinoma cells through the PI3K/Akt signaling pathway

Author:
Jun-Shan Liu; Chu-Ying Huo; Hui-Hui Cao; Chun-Lin Fan; Jian-Yang Hu; Li-Juan Deng; Zi-Bin Lu; Hua-Yi Yang; Lin-Zhong Yu; Zhi-Xian Mo; Zhi-Ling Yu
Source:
Phytomedicine 2019 v.61 pp. 152843
ISSN:
0944-7113
Subject:
Danio rerio; Oriental traditional medicine; Sophora alopecuroides; Western blotting; apoptosis; caspase-3; caspase-9; cell cycle checkpoints; cyclins; cytochrome c; cytosol; drug therapy; flow cytometry; hepatoma; humans; membrane potential; mitochondria; mitochondrial membrane; models; neoplasm cells; signal transduction; small interfering RNA; staining; transfection
Abstract:
... Hepatocellular carcinoma (HCC) ranks third among the most common causes of cancer-related deaths worldwide. The chemotherapy for HCC is still insufficient, so far. In searching for effective anti-HCC agents from traditional Chinese medicine, we discovered that aloperine (ALO), a quinolizidine alkaloid from Sophora alopecuroides L., exerts anti-HCC activities. However, the effects of ALO on HCC hav ...
DOI:
10.1016/j.phymed.2019.152843

42. Alpinia katsumadai Extracts Inhibit Adhesion and Invasion of Campylobacter jejuni in Animal and Human Foetal Small Intestine Cell Lines

Author:
Maja Šikić Pogačar; Anja Klančnik; Franz Bucar; Tomaž Langerholc; Sonja Smole Možina
Source:
Phytotherapy research 2015 v.29 no.10 pp. 1585-1589
ISSN:
0951-418X
Subject:
Alpinia; Campylobacter jejuni; Oriental traditional medicine; cell lines; cytotoxicity; diarrhea; epithelium; foods; humans; hydrodistillation; minimum inhibitory concentration; pain; pathogenesis; plant extracts; seeds; small intestine; testing; wastes
Abstract:
... Alpinia katsumadai is used in traditional Chinese medicine for abdominal distention, pain, and diarrhoea. Campylobacter jejuni is the most common cause of bacterial food‐borne diarrhoeal illnesses worldwide. Adhesion to gut epithelium is a prerequisite in its pathogenesis. The antimicrobial, cytotoxic, and anti‐adhesive activities of a chemically characterised extract (SEE) and its residual materi ...
DOI:
10.1002/ptr.5396

43. Alteration of intestinal flora by the intake of enzymatic degradation products of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) with improvement of skin condition

Author:
Mie Nishimura; Tatsuya Ohkawara; Hiroyo Kagami-Katsuyama; Shizuko Sekiguchi; Toshio Taira; Mana Tsukada; Hiroki Shibata; Jun Nishihira
Source:
Journal of functional foods 2014 v.7 pp. 487-494
ISSN:
1756-4646
Subject:
Bacteroidetes; Coix lacryma-jobi; Oriental traditional medicine; humans; intestinal microorganisms; placebos
Abstract:
... Adlay has been used as a traditional Chinese medicine and nutrient for its beneficial effects on bowel movements and skin care. This study examined the effect of enzymatic degradation product of adlay, “Super Hatomugi” (SPH) on human skin and the intestinal flora in a randomized, double-blind placebo-controlled study. The subjects were divided into three groups: 500mg SPH, 1000mg SPH, and placebo, ...
DOI:
10.1016/j.jff.2014.01.007

44. Alterations in tyrosine protein phosphorylation induced by matrine in leukemia cells

Author:
Liu, X.S.; Jiang, J.
Source:
Pharmaceutical biology 2005 v.43 no.7 pp. 624-629
ISSN:
1388-0209
Subject:
chemoprevention; medicinal plants; plant extracts; signal transduction; roots; Sophora flavescens; alkaloids; antinutritional factors; cytochemistry; legumes; biochemical mechanisms; protein phosphorylation; herbal medicines; humans; phytochemicals; lymphocytic leukemia; tyrosine; Oriental traditional medicine; anticarcinogenic activity; China
DOI:
10.1080/13880200500303734

45. Amentoflavone enhances osteogenesis of human mesenchymal stem cells through JNK and p38 MAPK pathways

Author:
Xuan Zha; Zhoumei Xu; Yuyu Liu; Liangliang Xu; Hongxin Huang; Jingjing Zhang; Liao Cui; Chenhui Zhou; Daohua Xu
Source:
Natural medicines 2016 v.70 no.3 pp. 634-644
ISSN:
1340-3443
Subject:
Danio rerio; Ginkgo; Oriental traditional medicine; Selaginella tamariscina; Western blotting; alkaline phosphatase; antineoplastic activity; antioxidants; bone formation; gene expression regulation; humans; larvae; mineralization; mitogen-activated protein kinase; osteoblasts; signal transduction; stem cells; transcription factors
Abstract:
... Amentoflavone is a bioflavonoid found in a variety of traditional Chinese medicines such as Gingko and Selaginella tamariscina. It has been reported that amentoflavone has anti-inflammatory, antioxidant, antiviral and anticancer effects. However, the effect of amentoflavone on osteogenic differentiation of human mesenchymal stem cells (hMSCs) has not been studied. In this study, we aim to explore ...
DOI:
10.1007/s11418-016-0993-1

46. An Active Part of Artemisia sacrorum Ledeb. Attenuates Hepatic Lipid Accumulation through Activating AMP-Activated Protein Kinase in Human HepG2 Cells

Author:
Hai-Dan YUAN; Hai-Ying YUAN; Sung-Hyun CHUNG; Guang-Zhu JIN; Guang-Chun PIAO
Source:
Bioscience, biotechnology, and biochemistry 2010 v.74 no.2 pp. 322-328
ISSN:
1347-6947
Subject:
AMP-activated protein kinase; Artemisia gmelinii; Oriental traditional medicine; acetyl-CoA carboxylase; acyl coenzyme A; biotechnology; dose response; ethanol; fatty liver; fatty-acid synthase; gene expression; glucose transporters; humans; lipemic effect; lipogenesis; low density lipoprotein receptors; noninsulin-dependent diabetes mellitus; obesity; phosphorylation; stearoyl-CoA desaturase; sterols; triacylglycerols
Abstract:
... Artemisia sacrorum Ledeb. (Compositae) (ASL) is a traditional Chinese medicine used to treat different hepatic diseases. However, a hypolipidemic effect of ASL on fatty liver disease has not been reported. Therefore, we investigated whether 95% ethanol eluate (EE), an active part of ASL, would attenuate hepatic lipid accumulation in human HepG2 cells by activating AMP-activated protein kinase (AMP ...
DOI:
10.1271/bbb.90651

47. An aqueous extract of Poncirus fructus activates the prokinetic activity of 5-HT receptor subtype 4 without hERG interaction

Author:
Shim, Won-Sik; Back, Heejung; Jung, Sang-Won; Kim, Jun-Woo; Jang, Yongwoo; Lee, Byeongjun; Seo, Eun-Kyoung; Oh, Uhtaek; Shim, Chang-Koo
Source:
Journal of ethnopharmacology 2010 v.132 no.1 pp. 328-333
ISSN:
0378-8741
Subject:
in vivo studies; cyclic AMP; medicinal plants; plant extracts; genes; receptors; gastrointestinal transit; pretreatment; herbal medicines; serotonin; humans; in vitro studies; rats; electrophysiology; adverse effects; potassium channels; biochemical pathways; animal models; digestive system diseases; Poncirus trifoliata; Oriental traditional medicine; East Asia
Abstract:
... Aim of the study: Poncirus fructus (PF) - also known as the dried, immature fruit of Poncirus trifoliata (L.) Raf. (Rutaceae) - is a natural substance that has long been used for various gastrointestinal disorders in eastern Asia. An aqueous extract of PF (PF-W) has particularly potent gastroprokinetic effects, but its molecular mechanism was not well understood. Identification of the underlying p ...
DOI:
10.1016/j.jep.2010.08.042

48. An extract from medical leech improve the function of endothelial cells in vitro and attenuates atherosclerosis in ApoE null mice by reducing macrophages in the lesions

Author:
Yao Wang; Xin Zhao; Yun-Shan Wang; Shu-Liang Song; Hao Liang; Ai-Guo Ji
Source:
Biochemical and biophysical research communications 2014 v.455 pp. 119-125
ISSN:
0006-291X
Subject:
Oriental traditional medicine; adhesion; atherosclerosis; cell adhesion; chemotaxis; diet; dose response; endothelial cells; gene expression; humans; macrophages; messenger RNA; mice; monocytes; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:
... Medicinal leech has been widely used as a traditional Chinese medicine in cardiovascular diseases. However, its pharmaceutical effect is not fully revealed. The goal of this study was to determine whether a leech extract has the effect of anti-atherosclerosis in ApoE −/− mice and the mechanism of this effect.In vivo experiments: ApoE −/− mice fed on high-cholesterol diet were separated into 5 grou ...
DOI:
10.1016/j.bbrc.2014.10.135

49. An inhibitor of cathepsin K, icariin suppresses cartilage and bone degradation in mice of collagen-induced arthritis

Author:
Peijiao Sun; Yonggang Liu; Xiaoxia Deng; Chunmei Yu; Nasang Dai; Xianglian Yuan; Liping Chen; Shenye Yu; Wei Si; Xiumei Wang; Defeng Wu; Siguo Liu; Hai Pang
Source:
Phytomedicine 2013 v.20 pp. 975-979
ISSN:
0944-7113
Subject:
Oriental traditional medicine; animal models; blood serum; cartilage; cathepsin K; collagen; collagenase; disease severity; enzyme activity; females; flavonols; glycosides; humans; icariin; medicinal properties; mice; pathogenesis; patients; rheumatoid arthritis
Abstract:
... The collagenase cathepsin K has been shown important in the pathogenesis of rheumatoid arthritis (RA). Icariin is the major pharmacologically active flavonol diglycoside of Herba Epimedii, an herb used in Chinese traditional medicine to treat arthritis. We investigated whether icariin can inhibit the protease activity of cathepsin K and its effects on a murine model of collagen-induced arthritis ( ...
DOI:
10.1016/j.phymed.2013.04.019

50. An intelligentized strategy for endogenous small molecules characterization and quality evaluation of earthworm from two geographic origins by ultra-high performance HILIC/QTOF MSE and Progenesis QI

Author:
Jingxian Zhang; Wenzhi Yang; Shangrong Li; Shuai Yao; Peng Qi; Zhou Yang; Zijin Feng; Jinjun Hou; Luying Cai; Min Yang; Wanying Wu; De-an Guo
Source:
Analytical and bioanalytical chemistry 2016 v.408 no.14 pp. 3881-3890
ISSN:
1618-2642
Subject:
Oriental traditional medicine; case studies; computer software; databases; discriminant analysis; earthworms; humans; hydrophilic interaction chromatography; ions; least squares; mass spectrometry; metabolites; metabolome; principal component analysis; quality control; reference standards; reversed-phase high performance liquid chromatography
Abstract:
... Animal-derived medicines have been a vital component for traditional Chinese medicine. However, their quality control remains challenging due to the large polarity of the contained endogenous small molecules (ESMs) that are difficult to separate by reversed-phase HPLC. Herein, an intelligentized strategy by ultra-high performance hydrophilic interaction chromatography/quadrupole time-of-flight mas ...
DOI:
10.1007/s00216-016-9482-3