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1. A dual function of copper in designing regenerative implants

Author:
Burghardt, Ines; Lüthen, Frank; Prinz, Cornelia; Kreikemeyer, Bernd; Zietz, Carmen; Neumann, Hans-Georg; Rychly, Joachim
Source:
Biomaterials 2015 v.44 pp. 36-44
ISSN:
0142-9612
Subject:
Staphylococcus aureus; alkaline phosphatase; antimicrobial properties; bacteria; bacterial infections; bone formation; bone marrow; collagen; copper; humans; mineralization; orthopedics; osteopontin; plankton; stem cells; titanium
Abstract:
... The supply of titanium implants which are widely used in orthopaedics with both regenerative and anti-microbial properties will achieve a great progress in bone regeneration. We asked, whether by appropriate concentrations of copper ions it will be possible both to inhibit growth of bacteria and stimulate biological responses in mesenchymal stem cells (MSC). Using titanium material which released ...
DOI:
10.1016/j.biomaterials.2014.12.022

2. A facile method to prepare translucent anatase thin films in monolithic structures for gas stream purification

Author:
Rodrigues-Silva, Caio; Monteiro, Ricardo A. R.; Dezotti, Márcia; Silva, Adrián M. T.; Pinto, Eugénia; Boaventura, Rui A. R.; Vilar, Vítor J. P.
Source:
Environmental science and pollution research international 2018 v.25 no.28 pp. 27796-27807
ISSN:
0944-1344
Subject:
Pseudomonas aeruginosa; Staphylococcus aureus; air flow; bacteria; bioaerosols; cellulose acetate; collectors; decontamination; gases; humidity; lighting; mineralization; models; nanoparticles; oxidation; oxygen; photocatalysis; photocatalysts; sol-gel processing; solar radiation; streams; titanium; titanium dioxide; ultraviolet radiation; volatile organic compounds
Abstract:
... In the present work, a facile method to prepare translucent anatase thin films on cellulose acetate monolithic (CAM) structures was developed. A simple sol–gel method was applied to synthesize photoactive TiO₂ anatase nanoparticles using tetra-n-butyl titanium as precursor. The immobilization of the photocatalyst on CAM structures was performed by a simple dip-coating method. The translucent anata ...
DOI:
10.1007/s11356-018-2008-0

3. Assessment of solar driven TiO2-assisted photocatalysis efficiency on amoxicillin degradation

Author:
Pereira, João H. O. S.; Reis, Ana C.; Nunes, Olga C.; Borges, Maria T.; Vilar, Vítor J. P.; Boaventura, Rui A. R.
Source:
Environmental science and pollution research international 2014 v.21 no.2 pp. 1292-1303
ISSN:
0944-1344
Subject:
Escherichia coli; Staphylococcus aureus; amoxicillin; anions; antibacterial properties; carboxylic acids; detection limit; dissolved organic carbon; hydroxyl radicals; inorganic ions; mineralization; molecular weight; nitrogen; photolysis; singlet oxygen; solar radiation; sulfur; veterinary medicine
Abstract:
... The objective of this work was to evaluate the efficiency of a solar TiO₂-assisted photocatalytic process on amoxicillin (AMX) degradation, an antibiotic widely used in human and veterinary medicine. Firstly, solar photolysis of AMX was compared with solar photocatalysis in a compound parabolic collectors pilot scale photoreactor to assess the amount of accumulated UV energy in the system (QUV) ne ...
DOI:
10.1007/s11356-013-2014-1

4. BMP2-loaded titania nanotubes coating with pH-responsive multilayers for bacterial infections inhibition and osteogenic activity improvement

Author:
Tao, Bailong; Deng, Yiman; Song, Liying; Ma, Wenwen; Qian, Ying; Lin, Chuanchuan; Yuan, Zhang; Lu, Lu; Chen, Maowen; Yang, Xin; Cai, Kaiyong
Source:
Colloids and surfaces 2019 v.177 pp. 242-252
ISSN:
0927-7765
Subject:
Escherichia coli; Staphylococcus aureus; alginates; alkaline phosphatase; bacterial infections; bone formation; bone morphogenetic proteins; chitosan; coatings; coculture; colloids; enzyme activity; gene expression; mineralization; nanotubes; orthopedics; osteoblasts; prostheses; titanium; titanium dioxide
Abstract:
... Bacterial infection and surface biointertness are two main causes for titanium (Ti)-based orthopedic implants failure. To improve the antibacterial ability and enhance poor osteogenic property of Ti substrates, in this work, we employed titania nanotubes (TNTs) as Bone Morphogenetic Protein 2 (BMP2) carrier, and a pH-responsive multilayer film composed of alginate dialdehyde-gentamicin (ADA-Gen) a ...
DOI:
10.1016/j.colsurfb.2019.02.014

5. CHI3L1 regulation of inflammation and the effects on osteogenesis in a Staphylococcus aureus‐induced murine model of osteomyelitis

Author:
Chen, XueQiu; Jiao, Jian; He, XiaoQing; Zhang, JianPing; Wang, Hai; Xu, YongQing; Jin, Tao
Source:
The FEBS journal 2017 v.284 no.11 pp. 1738-1747
ISSN:
1742-464X
Subject:
RNA interference; Staphylococcus aureus; animal models; blood; bone formation; bone marrow; chitinase; cytokines; femur; genes; inflammation; mice; micro-computed tomography; mineralization; osteoblasts; osteoclasts; osteomyelitis; patients; signal transduction; small interfering RNA
Abstract:
... Osteomyelitis is an inflammation of the bone and bone marrow that occurs as a consequence of infections mainly attributed to Staphylococcus aureus. In a previous study, we found that expression of the chitinase 3‐like 1 (CHI3L1) gene affected mineralization of MC3T3‐E1 cells infected with S. aureus and there was increased expression of CHI3L1 in the blood of osteomyelitis patients. In the present ...
DOI:
10.1111/febs.14082

6. Comparative Evaluation of Photo-Chemical AOPs for Ciprofoxacin Degradation: Elimination in Natural Waters and Analysis of pH Effect, Primary Degradation By-Products, and the Relationship with the Antibiotic Activity

Author:
Villegas-Guzman, Paola; Oppenheimer-Barrot, Sara; Silva-Agredo, Javier; Torres-Palma, Ricardo A.
Source:
Water, air, and soil pollution 2017 v.228 no.6 pp. 209
ISSN:
0049-6979
Subject:
Escherichia coli; Staphylococcus aureus; antibacterial properties; bacteria; byproducts; ciprofloxacin; hydroxyl radicals; mineralization; oxidation; pH; titanium dioxide
Abstract:
... In this work, ciprofloxacin (CIP) degradation is investigated using different photo-chemical advanced oxidation processes (AOPs): Fe²⁺/H₂O₂/UV, TiO₂/UV, and H₂O₂/UV. At natural pH, direct oxidation at the photo-generated holes showed to be the main pathway during TiO₂/UV process, while H₂O₂/UV and Fe²⁺/H₂O₂/UV degradation mainly occurred by hydroxyl radical attack. The identification of degradatio ...
DOI:
10.1007/s11270-017-3388-3

7. Controlled Release of Naringin in Metal-Organic Framework-Loaded Mineralized Collagen Coating to Simultaneously Enhance Osseointegration and Antibacterial Activity

Author:
Yu, Mengfei; You, Dongqi; Zhuang, Junjun; Lin, Suya; Dong, Lingqing; Weng, Shengtao; Zhang, Bin; Cheng, Kui; Weng, Wenjian; Wang, Huiming
Source:
ACS applied materials 2017 v.9 no.23 pp. 19698-19705
ISSN:
1944-8252
Subject:
Staphylococcus aureus; antibacterial properties; bacterial infections; bone formation; cell growth; coatings; collagen; coordination polymers; herbal medicines; mineralization; nanocrystals; naringin; orthopedics; prostheses; stem cells; synergism; titanium
Abstract:
... Two important goals in orthopedic implant research are to promote osseointegration and prevent infection. However, much previous effort has been focused on the design of coatings to either enhance osseointegration while ignoring antibacterial activity or vice versa, to prevent infection while ignoring bone integration. Here, we designed a multifunctional mineralized collagen coating on titanium wi ...
DOI:
10.1021/acsami.7b05296

8. Dorsal black skin necrosis in a Vietnamese pot‐bellied pig

Author:
Frank, Linda A.; McCormick, Karen A.; Donnell, Robert L.; Kania, Stephen A.
Source:
Veterinary dermatology 2015 v.26 no.1 pp. 64
ISSN:
0959-4493
Subject:
Staphylococcus aureus; anesthesia; antibiotics; biopsy; case studies; debridement; ears; epithelium; face; females; fever; fistula; histopathology; mineralization; necrosis; nose; oxygen; pain; pruritus; skin lesions; swine; veterinary medicine
Abstract:
... BACKGROUND: Thermal burns are an uncommon cause of injury in large animals. CASE REPORT: A 10‐month‐old pet female black and white Vietnamese pot‐bellied pig presented to the emergency service with fever and erythematous to purpuric skin lesions affecting the intermandibular space and hocks. One week prior to the emergency visit, she had appeared restless and in pain. Two weeks following the emerg ...
DOI:
10.1111/vde.12181

9. Electrochemical advanced oxidation processes for Staphylococcus aureus disinfection in municipal WWTP effluents

Author:
Valero, Pilar; Verbel, Martha; Silva-Agredo, Javier; Mosteo, Rosa; Ormad, Maria P.; Torres-Palma, Ricardo A.
Source:
Journal of environmental management 2017 v.198 pp. 256-265
ISSN:
0301-4797
Subject:
Staphylococcus aureus; anodes; bacteria; carbon; cathodes; disinfection; effluents; electrochemistry; hydrogen peroxide; iron; mineralization; oxidants; oxidation; pH; synergism; wastewater treatment
Abstract:
... This paper presents the Staphylococcus aureus inactivation in a simulated wastewater treatment plant effluent by different electrochemical techniques, including the photo-electro-Fenton process. S. aureus, dissolved organic carbon (DOC), total oxidants and H2O2 concentrations, as well as pH, were monitored during the assays. An electrolytic cell, including a UVA lamp, a gas diffusion electrode (GD ...
DOI:
10.1016/j.jenvman.2017.04.070

10. Enhanced antibacterial activity and osteoinductivity of Ag-loaded strontium hydroxyapatite/chitosan porous scaffolds for bone tissue engineering

Author:
XuZheng-Liang Xu and Yong Lei contributed equally to this work., Zheng-Liang; Lei, Yong; Yin, Wen-Jing; Chen, Yi-Xuan; Ke, Qin-Fei; Guo, Ya-Ping; Zhang, Chang-Qing
Source:
Journal of materials chemistry B 2016 v.4 no.48 pp. 7919-7928
ISSN:
2050-7518
Subject:
Staphylococcus aureus; alkaline phosphatase; antibacterial properties; biocompatibility; bone marrow; cell adhesion; chitosan; extracellular matrix; freeze drying; genes; humans; hydroxyapatite; ions; macropores; mesenchymal stromal cells; mineralization; nanosilver; porosity; silver; strontium; tissue engineering
Abstract:
... The properties of bone scaffolds, including biocompatibility, osteoinductivity and antibacterial activity, are of great importance for reconstruction of large bone defects and prevention of implant-associated infections. Herein, we develop an Ag-loaded strontium hydroxyapatite (SrHAP)/chitosan (CS) porous scaffold (Ag–SrHAP/CS) according to the following steps: (i) freeze-drying fabrication of a S ...
DOI:
10.1039/c6tb01282e

11. Enhanced bone tissue regeneration by antibacterial and osteoinductive silica-HACC-zein composite scaffolds loaded with rhBMP-2

Author:
Zhou, Panyu; Xia, Yan; Cheng, Xiaosong; Wang, Panfeng; Xie, Yang; Xu, Shuogui
Source:
Biomaterials 2014 v.35 no.38 pp. 10033-10045
ISSN:
0142-9612
Subject:
Escherichia coli; Staphylococcus aureus; ammonium chloride; animal models; antibacterial properties; bacterial adhesion; biocompatibility; biodegradability; bone formation; bone marrow; chitosan; confocal laser scanning microscopy; histology; micro-computed tomography; mineralization; muscles; nanoparticles; orthopedics; porous media; prostheses; quaternary ammonium compounds; rabbits; silica; tissue engineering; tissue repair; zein
Abstract:
... Next-generation orthopedic implants with both osteoinductivity and antibacterial ability are greatly needed. In the present study, biodegradable rhBMP-2 loaded zein-based scaffolds with a macroporous structure were synthesized, and SBA-15 nanoparticles and hydroxypropyltrimethyl ammonium chloride chitosan (HACC) were incorporated into the scaffolds to produce an anti-infective composite scaffold f ...
DOI:
10.1016/j.biomaterials.2014.09.009

12. Enhanced osteoblast functions and bactericidal effect of Ca and Ag dual-ion implanted surface layers on nanograined titanium alloys

Author:
Huang, Run; Han, Yong; Lu, Shemin
Source:
Journal of materials chemistry B 2014 v.2 no.28 pp. 4531-4543
ISSN:
2050-7518
Subject:
Escherichia coli; Staphylococcus aureus; alloys; antibacterial properties; bacterial adhesion; biocompatible materials; bone formation; calcium; extracellular matrix; gene expression; hydrophilicity; ions; microstructure; mineralization; nanosilver; osteoblasts; protein content; silver; surface roughness; titanium
Abstract:
... To endow a Ti-based implant with enhanced osteogenic activity and antibacterial property, we herein modified nano-grained (NG) and coarse-grained (CG) Ti surface layers by the implantation of Ca and/or Ag ions, which were derived by surface mechanical attrition treatment (SMAT). The cellular adhesion, proliferation, differentiation (as marked by the osteogenesis-related gene expression, ALP activi ...
DOI:
10.1039/c4tb00124a

13. Enhanced properties of injectable chitosan-based thermogelling hydrogels by silk fibroin and longan seed extract for bone tissue engineering

Author:
Pankongadisak, Porntipa; Suwantong, Orawan
Source:
International journal of biological macromolecules 2019 v.138 pp. 412-424
ISSN:
0141-8130
Subject:
Escherichia coli; Staphylococcus aureus; antimicrobial properties; bones; cell lines; chitosan; drug carriers; fibroblasts; fibroins; hydrogels; longans; mice; microstructure; mineralization; osteoblasts; seed extracts; temperature; tissue engineering
Abstract:
... In this study, the injectable thermogelling hydrogels under physiological temperature were prepared using chitosan (CS) and silk fibroin (SF). These hydrogels were loaded with crude water extract of longan seed (WLS) to improve osteoblast differentiation and stimulate mineralization in bone cells. These hydrogels showed a sol-to-gel transition time at 37 °C approximately 4–10 min and the formation ...
DOI:
10.1016/j.ijbiomac.2019.07.100

14. Fast mineralization and detoxification of amoxicillin and diclofenac by photocatalytic ozonation and application to an urban wastewater

Author:
Moreira, Nuno F.F.; Orge, Carla A.; Ribeiro, Ana R.; Faria, Joaquim L.; Nunes, Olga C.; Pereira, M. Fernando R.; Silva, Adrián M.T.
Source:
Water research 2015 v.87 pp. 87-96
ISSN:
0043-1354
Subject:
Escherichia coli; Staphylococcus aureus; amoxicillin; aqueous solutions; carbon; diclofenac; drugs; growth retardation; hormones; microorganisms; mineralization; oxidation; ozonation; ozone; pesticides; photocatalysis; photolysis; pollutants; toxicity; vapors; wastewater
Abstract:
... The degradation of two organic pollutants (amoxicillin and diclofenac) in 0.1 mM aqueous solutions was studied by using advanced oxidation processes, namely ozonation, photolysis, photolytic ozonation, photocatalysis and photocatalytic ozonation. Diclofenac was degraded quickly under direct photolysis by artificial light (medium-pressure vapor arc, λexc > 300 nm), while amoxicillin remained very s ...
DOI:
10.1016/j.watres.2015.08.059

15. Hydroxyapatite mineralization on chitosan-tragacanth gum/silica@silver nanocomposites and their antibacterial activity evaluation

Author:
Mallakpour, Shadpour; Abbasi, Mohaddeseh
Source:
International journal of biological macromolecules 2020 v.151 pp. 909-923
ISSN:
0141-8130
Subject:
Escherichia coli; Staphylococcus aureus; acetic acid; antibacterial properties; aqueous solutions; bacteria; body fluids; chitosan; hydroxyapatite; mineralization; moieties; nanocomposites; nanoparticles; nanosilver; polymers; silica; silver; surface area; tissue engineering; ultrasonics
Abstract:
... The goal of this research was the fabrication of chitosan (CT)-tragacanth gum (TG)/SiO₂ nanocomposite as a potential use in tissue engineering. For the antibacterial activity induction and stabilization of SiO₂ nanoparticles (NPs) in the polymer matrix, SiO₂ and green synthesized Ag NPs were hybrid with SiO₂/Ag. Then, the obtained hybrids were inserted into the CT-TG blend, separately. The ultraso ...
DOI:
10.1016/j.ijbiomac.2020.02.167

16. Immobilization strategy for optimizing VEGF's concurrent bioactivity towards endothelial cells and osteoblasts on implant surfaces

Author:
Hu, Xuefeng; Neoh, Koon Gee; Zhang, Jieyu; Kang, En-Tang; Wang, Wilson
Source:
Biomaterials 2012 v.33 no.32 pp. 8082-8093
ISSN:
0142-9612
Subject:
Staphylococcus aureus; adhesion; anti-infective agents; bacterial infections; coculture; endothelial cells; hydrophilicity; mineralization; osteoblasts; prostheses; titanium; vascular endothelial growth factors
Abstract:
... Orthopedic implant failure is mainly due to defective osseointegration and bacterial infection. Hence, a promising strategy to overcome these two problems is to functionalize the implant surface with both growth factors (GFs) and anti-infective agents. Covalent immobilization is widely used for such functionalization, but few studies have investigated the possible decrease in the GF's bioactivity ...
DOI:
10.1016/j.biomaterials.2012.07.057

17. In vitro evaluation of novel low-pressure spark plasma sintered HA–BG composite scaffolds for bone tissue engineering

Author:
Rizwan, Muhammad; Genasan, Krishnamurithy; Murali, Malliga Raman; Balaji Raghavendran, Hanumantha Rao; Alias, Rodianah; Cheok, Yi Ying; Wong, Won Fen; Mansor, Azura; Hamdi, M.; Basirun, Wan Jeffrey; Kamarul, Tunku
Source:
RSC advances 2020 v.10 no.40 pp. 23813-23828
ISSN:
2046-2069
Subject:
Fourier transform infrared spectroscopy; Staphylococcus aureus; Staphylococcus epidermidis; X-ray diffraction; alizarin; antimicrobial properties; apatite; biocompatibility; bone formation; bone morphogenetic proteins; bones; calcium; cell movement; chemokine CCL2; collagen; hardness; humans; hydrophilicity; in vitro studies; mesenchymal stromal cells; mineralization; monocytes; orthopedics; protein secretion; scanning electron microscopy; staining; tissue engineering; wettability
Abstract:
... The low-pressure spark plasma sintering (SPS) technique is adopted to fabricate hydroxyapatite–bioglass (HA–BG) scaffolds while maintaining the physical properties of both components, including their bulk and relative density and hardness. However, prior to their orthopaedic and dental applications, these scaffolds must be validated via pre-clinical assessments. In the present study, scaffolds wit ...
DOI:
10.1039/d0ra04227g

18. Light at the end of the tunnels? The origins of microbial bioerosion in mineralised collagen

Author:
Turner-Walker, Gordon
Source:
Palaeogeography, palaeoclimatology, palaeoecology 2019 v.529 pp. 24-38
ISSN:
0031-0182
Subject:
Cyanobacteria; Staphylococcus aureus; aquatic environment; bioerosion; bones; collagen; cows; diagenesis; dissolved oxygen; drying; fungi; hydrology; intestinal microorganisms; mercury; microstructure; mineralization; models; osteomyelitis; porosimetry; scanning electron microscopy; soil bacteria; soil biota; teeth; tropical soils
Abstract:
... Microbial bioerosion, in all its manifestations, is one of the major factors determining the long-term survival of archaeologically and environmentally important artefacts and ecofacts made from mineralised collagen – bones, antler, teeth and ivory. The bone diagenesis literature contains extensive descriptions of different morphologies and classifications of microbial bioerosion – microscopical f ...
DOI:
10.1016/j.palaeo.2019.05.020

19. Multifunctional Copper-Containing Carboxymethyl Chitosan/Alginate Scaffolds for Eradicating Clinical Bacterial Infection and Promoting Bone Formation

Author:
Lu, Yao; Li, Lihua; Zhu, Ye; Wang, Xiaolan; Li, Mei; Lin, Zefeng; Hu, Xiaoming; Zhang, Yu; Yin, Qingshui; Xia, Hong; Mao, Chuanbin
Source:
ACS applied materials & interfaces 2018 v.10 no.1 pp. 127-138
ISSN:
1944-8252
Subject:
Staphylococcus aureus; alginates; bacteria; bacterial infections; biocompatibility; bone formation; bones; calcium; cell adhesion; chitosan; copper; copper nanoparticles; crosslinking; freeze drying; gene expression; genes; in vitro studies; in vivo studies; ions; mineralization; non-specific protein-tyrosine kinase; pathogens; polymers
Abstract:
... Repairing infected bone defects relies on a scaffold that can not only fill the defects to promote bone formation but also kill clinically present bacterial pathogens such as Staphylococcus aureus (S. aureus). To meet this demand, here, we develop a new copper (Cu) containing natural polymeric scaffold with a full potential for repairing infected bone defects. Instead of directly adding antibacter ...
DOI:
10.1021/acsami.7b13750
PubMed:
29256580
PubMed Central:
PMC5764773

20. Nisin-loaded polydopamine/hydroxyapatite composites: Biomimetic synthesis, and in vitro bioactivity and antibacterial activity evaluations

Author:
Wang, Ni; Yu, Xing; Kong, Qingjun; Li, Zhenni; Li, Penghui; Ren, Xueyan; Peng, Bo; Deng, Ziwei
Source:
Colloids and surfaces 2020 v.602 pp. 125101
ISSN:
0927-7757
Subject:
Gram-positive bacteria; Staphylococcus aureus; T-lymphocytes; X-ray diffraction; X-ray photoelectron spectroscopy; antibacterial properties; bacterial adhesion; biocompatible materials; biomimetic synthesis; crystal structure; dopamine; drugs; embryo (animal); energy-dispersive X-ray analysis; engineering; human health; humans; hydroxyapatite; infrared spectroscopy; kidneys; microbial contamination; mineralization; moieties; nisin; scanning electron microscopy; solvents; transmission electron microscopy
Abstract:
... Microbial contamination caused by bacterial adhesion and colonization onto the materials surfaces has long been a serious threat to human health. Thus, it is imperative to develop advanced antimicrobial materials for bio-applications. Here, a unique polydopamine/ hydroxyapatite/nisin (PDA/HAP/Nisin) composite with good bioactivities and enhanced antibacterial activities have been developed. The un ...
DOI:
10.1016/j.colsurfa.2020.125101

21. Novel SiO₂/PDA hybrid coatings to promote osteoblast-like cell expression on titanium implants

Author:
Ho, Chia-Che; Ding, Shinn-Jyh
Source:
Journal of materials chemistry B 2015 v.3 no.13 pp. 2698-2707
ISSN:
2050-7518
Subject:
Pseudomonas aeruginosa; Staphylococcus aureus; adhesion; antibacterial properties; bone formation; bones; coatings; corrosion; humans; microstructure; mineralization; mortality; osteoblasts; physicochemical properties; silica; titanium
Abstract:
... Poor bonding between bone tissue and noble titanium (Ti) surfaces is one of the major problems that should be resolved. Given that SiO₂ is a documented differentiation promoter and polydopamine (PDA) is an adhesive molecule, it is worthwhile to investigate the synergetic performance of novel silica/polydopamine (SiO₂/PDA) hybrid coatings on Ti substrates. The physicochemical properties of PDA, 2Si ...
DOI:
10.1039/c4tb01841a

22. Osteogenic activity and antibacterial effect of zinc ion implanted titanium

Author:
Jin, Guodong; Cao, Huiliang; Qiao, Yuqin; Meng, Fanhao; Zhu, Hongqin; Liu, Xuanyong
Source:
Colloids and Surfaces B: Biointerfaces 2014 v.117 pp. 158-165
ISSN:
0927-7765
Subject:
Escherichia coli; Staphylococcus aureus; X-ray photoelectron spectroscopy; adhesion; alloys; antibacterial properties; cell adhesion; collagen; colloids; dental prosthesis; extracellular matrix; mineralization; normal distribution; orthopedics; oxalic acid; rats; scanning electron microscopy; secretion; stem cells; titanium; zinc; zinc oxide
Abstract:
... Titanium (Ti) and its alloys are widely used as orthopedic and dental implants. In this work, zinc (Zn) was implanted into oxalic acid etched titanium using plasma immersion ion implantation technology. Scanning electron microscopy and X-ray photoelectron spectroscopy were used to investigate the surface morphology and composition of Zn-implanted titanium. The results indicate that the depth profi ...
DOI:
10.1016/j.colsurfb.2014.02.025

23. Pectin-bioactive glass self-gelling, injectable composites with high antibacterial activity

Author:
Douglas, Timothy E.L.; Dziadek, Michal; Schietse, Josefien; Boone, Matthieu; Declercq, Heidi A.; Coenye, Tom; Vanhoorne, Valérie; Vervaet, Chris; Balcaen, Lieve; Buchweitz, Maria; Vanhaecke, Frank; Van Assche, Frederic; Cholewa-Kowalska, Katarzyna; Skirtach, Andre G.
Source:
Carbohydrate polymers 2019 v.205 pp. 427-436
ISSN:
0144-8617
Subject:
Staphylococcus aureus; antibacterial properties; apple pomace; body fluids; calcium; citrus peels; esterification; gelation; glass; hydrogels; in vitro studies; ions; micro-computed tomography; mineralization; mixing; osteoblasts; pectins
Abstract:
... The present work focuses on the development of novel injectable, self-gelling composite hydrogels based on two types of low esterified amidated pectins from citrus peels and apple pomace. Sol-gel-derived, calcium-rich bioactive glass (BG) fillers in a particle form are applied as delivery vehicles for the release of Ca2+ ions to induce internal gelation of pectins. Composites were prepared by a re ...
DOI:
10.1016/j.carbpol.2018.10.061

24. Promotion of the osteogenic activity of an antibacterial polyaniline coating by electrical stimulation

Author:
Zhu, Bengao; Li, Yuhan; Huang, Fuhui; Chen, Zhuoxin; Xie, Jing; Ding, Chunmei; Li, Jianshu
Source:
Biomaterials science 2019 v.7 no.11 pp. 4730-4737
ISSN:
2047-4849
Subject:
Escherichia coli; Staphylococcus aureus; alkaline phosphatase; antibacterial properties; biocompatibility; bone formation; calcium; chemical reduction; coatings; dendrimers; electrical treatment; microorganisms; mineralization; osteoblasts; polyaniline; polymerization; tissue repair; titanium
Abstract:
... Electrical stimulation (ES) exhibits a positive role in promoting the cell activity of osteoblasts. Conducting polymers have the advantages of biocompatibility, good environmental stability and easy synthesis, which have been widely used as charge carriers for electrical stimulation; moreover, considering clinical applications, biomaterial-related infection is an important issue that needs to be s ...
DOI:
10.1039/c9bm01203f

25. rBMSC and bacterial responses to isoelastic carbon fiber-reinforced poly(ether-ether-ketone) modified by zirconium implantation

Author:
Li, Jian; Qian, Shi; Ning, Congqin; Liu, Xuanyong
Source:
Journal of materials chemistry B 2015 v.4 no.1 pp. 96-104
ISSN:
2050-7518
Subject:
Escherichia coli; Staphylococcus aureus; X-ray photoelectron spectroscopy; adhesion; antibacterial properties; biocompatible materials; bone formation; bones; chemical composition; collagen; extracellular matrix; humans; ions; mechanical testing; mineralization; modulus of elasticity; nanoparticles; scanning electron microscopy; secretion; tissue engineering; zirconium; zirconium oxide
Abstract:
... PEEK-based biomaterials have great potential applications as hard tissue substitutes in bone tissue engineering. However, inherent bio-inert properties limited their clinical use. In order to improve the bioactivity, in this work, zirconium ions were implanted into the carbon fiber-reinforced PEEK (CFR-PEEK) using plasma immersion ion implantation (PIII) technology. Surface morphologies and chemic ...
DOI:
10.1039/c5tb01784j

26. Reduction of Silver Ions Using an Alkaline Cellulose Dope: Straightforward Access to Ag/ZnO Decorated Cellulose Nanocomposite Film with Enhanced Antibacterial Activities

Author:
Fu, Feiya; Gu, Jiayuan; Cao, Jinfeng; Shen, Rongsheng; Liu, Hanxiang; Zhang, Yanyan; Liu, Xiangdong; Zhou, Jinping
Source:
ACS sustainable chemistry & engineering 2018 v.6 no.1 pp. 738-748
ISSN:
2168-0485
Subject:
Escherichia coli; Staphylococcus aureus; antibacterial properties; bacteria; biomimetics; cellulose; gelation; industry; ions; mineralization; nanocomposites; nanohybrids; nanosilver; silver; silver nitrate; zinc oxide
Abstract:
... This work proposed a straightforward and sustainable strategy to synthesize a Ag/ZnO decorated cellulose nanocomposite. First, zincate was introduced into an aqueous cellulose–NaOH/urea dope to enhance the solution stability. Second, AgNO₃ was directly added into the cellulose dope without gelation, and then was reduced into Ag NPs by cellulose chain. Finally, zincate transformed into ZnO via biom ...
DOI:
10.1021/acssuschemeng.7b03059

27. Regulation of the Biological Functions of Osteoblasts and Bone Formation by Zn-Incorporated Coating on Microrough Titanium

Author:
Shen, Xinkun; Hu, Yan; Xu, Gaoqiang; Chen, Weizhen; Xu, Kui; Ran, Qichun; Ma, Pingping; Zhang, Yarong; Li, Jinghua; Cai, Kaiyong
Source:
ACS applied materials 2014 v.6 no.18 pp. 16426-16440
ISSN:
1944-8252
Subject:
Pseudomonas aeruginosa; Staphylococcus aureus; X-ray diffraction; X-ray photoelectron spectroscopy; acid phosphatase; adhesion; alkaline phosphatase; bacteria; bone formation; cell differentiation; cell proliferation; coatings; contact angle; gene expression; in vitro studies; in vivo studies; ions; micro-computed tomography; mineralization; orthopedics; osteoblasts; osteoclasts; prostheses; scanning electron microscopy; sol-gel processing; titanium; zinc; zinc oxide
Abstract:
... To improve the biological performance of titanium implant, a series of Zn-incorporated coatings were fabricated on the microrough titanium (Micro-Ti) via sol–gel method by spin-coating technique. The successful fabrication of the coating was verified by combined techniques of scanning electron microscopy, surface profiler, X-ray diffraction, X-ray photoelectron spectroscopy, and water contact angl ...
DOI:
10.1021/am5049338

28. Role of sulfate, chloride, and nitrate anions on the degradation of fluoroquinolone antibiotics by photoelectro-Fenton

Author:
Villegas-Guzman, Paola; Hofer, Florian; Silva-Agredo, Javier; Torres-Palma, Ricardo A.
Source:
Environmental science and pollution research international 2017 v.24 no.36 pp. 28175-28189
ISSN:
0944-1344
Subject:
Escherichia coli; Staphylococcus aureus; anions; anodes; antibacterial properties; antibiotics; byproducts; cathodes; chlorides; ciprofloxacin; hydroxyl radicals; iron; mineralization; models; nitrates; oxidation; pH; photolysis; seawater; sulfates
Abstract:
... Taking ciprofloxacin (CIP) as a fluoroquinolone antibiotic model, this work explores the role of common anions (sulfate, nitrate, and chloride) during the application of photoelectro-Fenton (PEF) at natural pH to degrade this type of compound in water. The system was composed of an IrO₂ anode, Ti, or gas diffusion electrode (GDE) as cathode, Fe²⁺, and UV (254 nm). To determine the implications of ...
DOI:
10.1007/s11356-017-0404-5

29. Stem cell differentiation-induced calcium silicate cement with bacteriostatic activity

Author:
Huang, Shu-Ching; Wu, Buor-Chang; Ding, Shinn-Jyh
Source:
Journal of materials chemistry B 2014 v.3 no.4 pp. 570-580
ISSN:
2050-7518
Subject:
Pseudomonas aeruginosa; Staphylococcus aureus; alkaline phosphatase; antibacterial properties; bone formation; calcium phosphates; calcium silicate; cell differentiation; cement; culture media; humans; mesenchymal stromal cells; mineralization; orthopedics; osteocalcin; stem cells; surgery
Abstract:
... Calcium-based bone cements are widely used in dental and orthopaedic surgery. Those based on calcium phosphate (CPCs) or calcium silicate (CSCs) have a number of favourable properties that encourage their clinical use in bone defect repair. The purpose of the present study was to compare the in vitro osteogenesis and bacteriostatic activity of BoneSource CPCs with home-made CSCs, particularly in r ...
DOI:
10.1039/c4tb01617c

30. Stimulation of cell responses and bone ingrowth into macro-microporous implants of nano-bioglass/polyetheretherketone composite and enhanced antibacterial activity by release of hinokitiol

Author:
Zhang, Jue; Wei, Wu; Yang, Lili; Pan, Yongkang; Wang, Xuehong; Wang, Tinglan; Tang, Songchao; Yao, Yuan; Hong, Hua; Wei, Jie
Source:
Colloids and surfaces 2018 v.164 pp. 347-357
ISSN:
0927-7765
Subject:
Staphylococcus aureus; antibacterial properties; apatite; bacterial infections; biocompatibility; bone formation; colloids; drugs; immunohistochemistry; macropores; micro-computed tomography; micropores; mineralization; orthopedics; porosity; porous media; prostheses; tissue repair
Abstract:
... Poor osteogenesis and bacterial infection lead to the failure of implants, thus enhancements of osteogenic activity and antibacterial activity of the implants have significances in orthopedic applications. In this study, macro-microporous bone implants of nano-bioglass (nBG) and polyetheretherketone (PK) composite (mBPC) were fabricated. The results indicated that the mBPC with the porosity of aro ...
DOI:
10.1016/j.colsurfb.2018.01.058

31. Surface functionalization of titanium substrates with chitosan–lauric acid conjugate to enhance osteoblasts functions and inhibit bacteria adhesion

Author:
Zhao, Lu; Hu, Yan; Xu, Dawei; Cai, Kaiyong
Source:
Colloids and Surfaces B: Biointerfaces 2014 v.119 pp. 115-125
ISSN:
0927-7765
Subject:
Fourier transform infrared spectroscopy; Pseudomonas aeruginosa; Staphylococcus aureus; adhesion; alkaline phosphatase; antibacterial properties; bacteria; bacterial adhesion; bacterial infections; cell viability; colloids; contact angle; dodecanoic acid; hydrogen; in vitro studies; mineralization; nuclear magnetic resonance spectroscopy; osteoblasts; prostheses; scanning electron microscopy; spectrometers; titanium; wettability
Abstract:
... Orthopedic implants failures are generally related to poor osseointegration and/or bacterial infection in clinical application. Surface functionalization of an implant is one promising alternative for enhancing osseointegration and/or reducing bacterial infection, thus ensuring the long term survival of the implant. In this study, titanium (Ti) substrates were surface functionalized with a polydop ...
DOI:
10.1016/j.colsurfb.2014.05.002

32. The inhibition of infection by wound pathogens on scaffold in tissue-forming process using N-acetyl cysteine

Author:
Yamada, Masahiro; Ishihara, Kazuyuki; Ogawa, Takahiro; Sakurai, Kaoru
Source:
Biomaterials 2011 v.32 no.33 pp. 8474-8485
ISSN:
0142-9612
Subject:
Streptococcus pyogenes; Staphylococcus aureus; alkaline phosphatase; bacterial infections; dose response; mineralization; tissue repair; extracellular matrix; reactive oxygen species; collagen; cysteine; osteoblasts; pathogens; in vitro studies; fibroblasts; bacteria; rats
Abstract:
... Prevention of local infection from wound pathogens such as Staphylococci and Streptococci is crucial for tissue regeneration. N-acetyl cysteine (NAC), an anti-oxidant amino acid derivative, has anti-microbial potential against various species. This in vitro study evaluated whether NAC prevented bacterial infection of gingival fibroblasts and osteoblasts on a scaffold. N-acetyl cysteine delayed gro ...
DOI:
10.1016/j.biomaterials.2011.07.074