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1. A lipid-soluble extract of Pinellia pedatisecta Schott orchestrates intratumoral dendritic cell-driven immune activation through SOCS1 signaling in cervical cancer

Author:
Wang, Yumeng; Lu, Chong; Huang, Haixia; Yao, Sheng; Xu, Congjian; Ye, Yang; Gui, Suiqi; Li, Guiling
Source:
Journal of ethnopharmacology 2021 v.267 pp. 112837
ISSN:
0378-8741
Subject:
Pinellia; Western blotting; apoptosis; biomarkers; bone marrow; dendritic cells; drugs; flow cytometry; gene silencing; genetic markers; humans; interleukin-12; medicinal plants; mice; models; neoplasm cells; non-specific protein-tyrosine kinase; phenotype; phosphorylation; quantitative polymerase chain reaction; traditional medicine; uterine cervical neoplasms
Abstract:
... Pinellia pedatisecta Schott extract (PE) is generated from Pinellia pedatisecta Schott, a traditional Chinese medicinal plant. PE suppresses cervical tumor growth and exhibits effects on dendritic cells (DCs) that lead to modulation of antitumor CD4⁺ and CD8⁺ responses.To explore the underlying mechanisms by which PE modulates tumor-associated dendritic cell (TADC) activation and function.DCs and ...
DOI:
10.1016/j.jep.2020.112837

2. Identification of lipidomic responses to GCRV infection in Ctenopharyngodon idellus kidney (CIK) cells

Author:
Zhang, Xing; Huang, Jingcai; Shen, Zeen; Wang, Yan; Wang, Yujun; Gong, Chengliang; Hu, Xiaolong; Wang, Chonglong
Source:
Aquaculture 2021 v.533 pp. 736106
ISSN:
0044-8486
Subject:
Ctenopharyngodon idella; Reoviridae; Western blotting; aquaculture; autophagy; biochemical pathways; droplets; financial economics; fish diseases; immune response; kidney cells; kidneys; lipid composition; lipid metabolism; lipidomics; pathogens; staining; triacylglycerols; virus replication; viruses
Abstract:
... Grass carp reovirus (GCRV) is a causing pathogen of grass carp hemorrhagic disease, whose outbreak often brings out a huge economic loss in aquaculture filed. Cellular lipids play crucial roles in many biological processes, such as virus replication, maturation and transmission. Presently, it remains to elucidate the roles of these lipids in the GCRV infection. In this study, Here, a lipidomic app ...
DOI:
10.1016/j.aquaculture.2020.736106

3. Development and characterization of novel cell lines from kidney and eye of rainbow trout, Oncorhynchus mykiss for virological studies

Author:
Suryakodi, S.; Majeed, S. Abdul; Taju, G.; Vimal, S.; Sivakumar, S.; Ahmed, A. Nafeez; Shah, Feroz Ahmad; Bhat, Saqib Ahmad; Sarma, Dandadhar; Begum, Ajima; Hameed, A.S. Sahul
Source:
Aquaculture 2021 v.532 pp. 736027
ISSN:
0044-8486
Subject:
Cyprinid herpesvirus 2; Nodaviridae; Oncorhynchus mykiss; Tilapia lake virus; Western blotting; cell growth; cell lines; cryopreservation; enzyme-linked immunosorbent assay; epithelium; eyes; fibronectins; fish; fluorescent antibody technique; kidneys; reverse transcriptase polymerase chain reaction; sequence analysis; spleen; viruses; India
Abstract:
... Two novel cell lines were developed from eye and kidney of rainbow trout, Oncorhynchus mykiss in addition to another cell line from spleen. All these cell lines were characterized and cryopreserved successfully at different passage levels. The cells of eye, kidney and spleen were sub-cultured continuously at an interval of 2–3 days and attained the passage level of 112, 106 and 112, respectively o ...
DOI:
10.1016/j.aquaculture.2020.736027

4. Development and characterization of polyclonal antibodies against subtype specific vitellogenin of the dojo loach, Misgurnus anguillicaudatus

Author:
Wang, Weilong; Lian, Qingping; Chen, Yuange; Hiramatsu, Naoshi; Wu, Meiqin
Source:
Aquaculture 2021 v.532 pp. 736089
ISSN:
0044-8486
Subject:
Misgurnus anguillicaudatus; Western blotting; antiserum; aquatic environment; biomarkers; chemiluminescence; estradiol; estrogenic properties; fish; genes; lowest observed effect level; males; polyclonal antibodies; vitellogenin
Abstract:
... Fish vitellogenin (Vtg) has become an important biomarker for assessing the estrogenic potency of chemicals and the exposure of animals to estrogenic contaminants present in aquatic environments. In the current study, the polyclonal antibodies against subtype-specific Vtgs of the dojo loach (Misgurnus anguillicaudatus) were developed and identified by gene recombination and expression. Immuno-bioc ...
DOI:
10.1016/j.aquaculture.2020.736089

5. Anti-depressant effect of Zhi-zi-chi decoction on CUMS mice and elucidation of its signaling pathway

Author:
Chai, Chuan; Jin, Bo; Yan, Yinyu; Yuan, Qi; Wen, Hongmei; Tao, Weiwei; Cui, Xiaobing; Shan, Chenxiao; Yu, Sheng
Source:
Journal of ethnopharmacology 2021 v.266 pp. 113283
ISSN:
0378-8741
Subject:
Oriental traditional medicine; Western blotting; amino acid metabolism; antidepressants; arginine; aspartic acid; biochemical pathways; biomarkers; blood serum; body weight; cAMP-dependent protein kinase; carbohydrate metabolism; fluoxetine; forced swimming test; gamma-aminobutyric acid; glutamic acid; glutamine; hippocampus; lipid metabolism; males; metabolites; metabolomics; mice; models; pharmacokinetics; phosphatidylcholines; proline; protein synthesis; signal transduction; sucrose; swimming; tail suspension test
Abstract:
... Zhi-zi-chi decoction (ZZCD) is used for treating depression as an effectively traditional Chinese medicine. Until now, studies on pharmacological research of ZZCD have mostly been centered in pharmacokinetic level. Little was known about its pharmacological mechanism of relieving depression.This study was to evaluate the effect of ZZCD on relieving depression via behavioral tests, serum metabolomi ...
DOI:
10.1016/j.jep.2020.113283

6. Apigenin attenuates TGF-β1-stimulated cardiac fibroblast differentiation and extracellular matrix production by targeting miR-155-5p/c-Ski/Smad pathway

Author:
Wang, Feng; Fan, Ke; Zhao, Ying; Xie, Mei-Lin
Source:
Journal of ethnopharmacology 2021 v.265 pp. 113195
ISSN:
0378-8741
Subject:
3' untranslated regions; Matricaria; Western blotting; actin; apigenin; cardiovascular diseases; chamomile; collagen; enzyme activity; extracellular matrix; fibroblasts; luciferase; muscles; mutants; quantitative polymerase chain reaction; reporter genes; synergism; traditional medicine; transfection; transforming growth factor beta 1
Abstract:
... Apigenin is a natural flavonoid compound present in chamomile (Matricaia chamomilla L.) from the Asteraceae family, which is used in the treatment of cardiovascular diseases by traditional healers, but its effects on differentiation and extracellular matrix (ECM) production of cardiac fibroblasts (CFs) induced by transforming growth factor beta 1 (TGF-β1) are poorly understood.This study aimed to ...
DOI:
10.1016/j.jep.2020.113195

7. Fucoxanthin extracted from Laminaria Japonica inhibits metastasis and enhances the sensitivity of lung cancer to Gefitinib

Author:
Ming, Jia Xiong; Wang, Zhao Cong; Huang, Yi; Ohishi, Hifumi; Wu, Rong Ji; Shao, Yan; Wang, Hui; Qin, Ming Yang; Wu, Ze Liang; Li, Yi Yong; Chang Zhou, Shun; Chen, Hui; Liu, Hui; Xu, Rong
Source:
Journal of ethnopharmacology 2021 v.265 pp. 113302
ISSN:
0378-8741
Subject:
Oriental traditional medicine; RNA interference; Saccharina japonica; Western blotting; antineoplastic activity; cadherins; cell lines; cell proliferation; cell viability; drugs; fibronectins; fluorescent antibody technique; gene expression; human diseases; immunohistochemistry; lung neoplasms; lungs; metastasis; models; neoplasm cells; phenotype; phosphatidylinositol 3-kinase; staining; tissue repair; transcription factor NF-kappa B; xenotransplantation
Abstract:
... Laminaria japonica, a brown seaweed, has been used in Traditional Chinese Medicine (TCM) to treat a variety of diseases including lung cancer.To demonstrate the effects of Fucoxanthin (FX), a major active component extracted from Laminaria japonica on metastasis and Gefitinib (Gef) sensitivity in human lung cancer cells both in vitro and in vivo.Invasion and migration of lung cancer cells were det ...
DOI:
10.1016/j.jep.2020.113302

8. Myosin light chain kinase mediates intestinal barrier dysfunction following simulated microgravity based on proteomic strategy

Author:
Wang, Shibo; Wang, Rui; Li, George Q.; Cho, Jun-Lae; Deng, Yulin; Li, Yujuan
Source:
Journal of proteomics 2021 v.231 pp. 104001
ISSN:
1874-3919
Subject:
Western blotting; adhesion; animal models; etiology; extracellular space; focal adhesions; gene expression regulation; goblet cells; histology; intestinal mucosa; microfilaments; microgravity; myosin; myosin light chain kinase; permeability; phosphorylation; protein synthesis; proteomics; rats; small intestine; therapeutics
Abstract:
... Microgravity induces injury of intestinal barrier. However, the underlying mechanism remains unclear. The present study aimed to investigate the pathological change of intestinal mucosa induced by long term simulated microgravity and to explore its etiological mechanism using a proteomic approach. The well accepted tail-suspended rat model was used to simulate microgravity. The damage of rat small ...
DOI:
10.1016/j.jprot.2020.104001

9. Quantitative proteomics of cerebrospinal fluid using tandem mass tags in dogs with recurrent epileptic seizures

Author:
Baka, Rania; Eckersall, David; Horvatic, Anita; Gelemanovic, Andrea; Mrljak, Vladimir; McLaughlin, Mark; Athanasiou, Labrini V.; Papaioannou, Nikolaos; Stylianaki, Ioanna; Hanh, Han Quang; Chadwick, Christopher C.; Polizopoulou, Zoe
Source:
Journal of proteomics 2021 v.231 pp. 103997
ISSN:
1874-3919
Subject:
Canis lupus; Western blotting; blood-brain barrier; brain; cerebrospinal fluid; data analysis; dogs; drug therapy; epilepsy; gene ontology; immunoassays; prospective studies; proteins; proteome; proteomics; seizures; spectrometers
Abstract:
... This prospective study included four dog groups (group A: healthy dogs, groups B: dogs with idiopathic epilepsy under antiepileptic medication (AEM), C: idiopathic epilepsy dogs without AEM administration, D: dogs with structural epilepsy). The purpose of the study was to compare the proteomic profile among the four groups. Samples were analyzed by a quantitative Tandem Mass Tags approach using a ...
DOI:
10.1016/j.jprot.2020.103997

10. Saliva-omics in plasma cell disorders- Proof of concept and potential as a non-invasive tool for monitoring disease burden

Author:
Tierney, Ciara; Bazou, Despina; Lê, Giao; Dowling, Paul; O'Gorman, Peter
Source:
Journal of proteomics 2021 v.231 pp. 104015
ISSN:
1874-3919
Subject:
B-lymphocytes; Western blotting; anemia; biomarkers; blood serum; burden of disease; disease progression; enzyme-linked immunosorbent assay; hypercalcemia; liquid chromatography; monitoring; myeloma; patients; precision medicine; protein synthesis; proteins; relapse; saliva; tandem mass spectrometry
Abstract:
... Multiple Myeloma (MM), the second most common lymphoid cancer worldwide, is characterised by the uninhibited proliferation of terminally differentiated B-lymphocytes. Leading to The diagnosis typically requires the presence of a monoclonal protein (M protein) and the demonstration of CRAB features (hypercalcemia, renal impairment, anaemia and bone lesions). MM is considered incurable as, due to se ...
DOI:
10.1016/j.jprot.2020.104015

11. Ameliorative effects of Qingganjiuwei powder, a traditional Mongolian medicine, against CCl4-induced liver fibrosis in rats

Author:
Ge, Hongyan; Wang, Anqing; Su, Ya; Yu, ChunLei; Gao, Lu; Li, Yuxin
Source:
Journal of ethnopharmacology 2021 v.264 pp. 113226
ISSN:
0378-8741
Subject:
Western blotting; actin; alanine transaminase; aspartate transaminase; blood serum; carbon tetrachloride; collagen; drugs; enzyme activity; fibrosis; gelatinase A; gene expression regulation; hematologic tests; histopathology; immunohistochemistry; liver; liver cirrhosis; messenger RNA; mitogen-activated protein kinase; models; muscles; necrosis; phosphorylation; protein synthesis; quantitative polymerase chain reaction; rats; signal transduction; silymarin; traditional medicine; China
Abstract:
... Qingganjiuwei powder (QGJWS) is a well-known traditional drug containing nine kinds of medicinal materials. This drug is commonly used in the Inner Mongolia region and exerts remarkable clinical effects on hepatic protection.To investigate whether QGJWS inhibits liver fibrosis in rats and to reveal its potential mechanisms.Liver fibrosis model was induced by CCl₄ for 8 weeks in SD rats. Next, rats ...
DOI:
10.1016/j.jep.2020.113226

12. Berberine inhibits intestinal epithelial barrier dysfunction in colon caused by peritoneal dialysis fluid by improving cell migration

Author:
Zhang, Dongliang; Jiang, Lan; Wang, Mengling; Jin, Meiping; Zhang, Xuemei; Liu, Difa; Wang, Zhangwei; Yang, Licai; Xu, Xudong
Source:
Journal of ethnopharmacology 2021 v.264 pp. 113206
ISSN:
0378-8741
Subject:
Coptis chinensis; Oriental traditional medicine; Western blotting; adhesion; berberine; cell movement; colon; dialysis; diarrhea; epithelial cells; gastrointestinal diseases; herbal medicines; histology; intestinal mucosa; medicinal plants; mice; microvilli; models; plant extracts; protective effect; rats; renal failure; rhizomes; staining; therapeutics; tight junctions; tissue repair; transmission electron microscopy
Abstract:
... Berberine is generally extracted from Rhizoma Coptidis (Coptis chinensis Franch), a traditional Chinese medicine, which can be used in the treatment of intestinal diseases, respiratory infections and cardiovascular diseases. Berberine is especially effective for the treatment of gastrointestinal disorders such as diarrhea because of the effect of heat-clearing and detoxifying in traditional Chines ...
DOI:
10.1016/j.jep.2020.113206

13. Effect of weimaining on apoptosis and Caspase-3 expression in a breast cancer mouse model

Author:
Ke, Haoliang; Wang, Xiuping; Zhou, Zhen; Ai, Wang; Wu, Zhaoyan; Zhang, Yingwen
Source:
Journal of ethnopharmacology 2021 v.264 pp. 113363
ISSN:
0378-8741
Subject:
Fagopyrum dibotrys; Western blotting; animal models; antineoplastic activity; apoptosis; bioluminescence; breast neoplasms; breasts; buckwheat; caspase-3; gene expression; gene expression regulation; heparin; herbal medicines; image analysis; intraperitoneal injection; messenger RNA; mice; neoplasm cells; nucleotidyltransferases; photons; proanthocyanidins; protein content; reverse transcriptase polymerase chain reaction; roots; sodium chloride; traditional medicine; xenotransplantation
Abstract:
... Weimaining (WMN) is a condensed Tannin compound extracted from Fagopyrum cymosum (Trevir.) Meisn., which comes from the roots of buckwheat, a type of Chinese herbal medicine, was first recorded in “Bencao Shiyi”. WMN has inhibitory effects on multiple cancer types and is widely used in clinical practice; however, the mechanism underlying the anti-tumor effect of WMN is still unclear.To investigate ...
DOI:
10.1016/j.jep.2020.113363

14. Ethanol extract of Liriodendron chinense (Hemsl.) Sarg barks attenuates hyperuricemic nephropathy by inhibiting renal fibrosis and inflammation in mice

Author:
Pan, Jing; Zhang, Chunle; Shi, Min; Guo, Fan; Liu, Jing; Li, Lingzhi; Ren, Qian; Tao, Sibei; Tang, Minghai; Ye, Haoyu; Ma, Liang; Fu, Ping
Source:
Journal of ethnopharmacology 2021 v.264 pp. 113278
ISSN:
0378-8741
Subject:
ABC transporters; Liriodendron tulipifera; Oriental traditional medicine; Western blotting; adenine; animal models; blood serum; creatinine; ethanol; excretion; fibrosis; fluorescent antibody technique; gout; histochemistry; histopathology; inflammation; kidney diseases; kidneys; mice; mitogen-activated protein kinase; non-specific protein-tyrosine kinase; oral administration; potassium; protective effect; quantitative polymerase chain reaction; renal function; reverse transcriptase polymerase chain reaction; signal transduction; transcription factor NF-kappa B; tumor necrosis factor-alpha; urea nitrogen; uric acid; urine; China
Abstract:
... Liriodendron chinense (Hemsl.) Sarg, known as the Chinese tulip tree, has a long history of cultivation and utilization in many Asia countries, especially in China to use in traditional Chinese medicine for expelling “wind and dampness”, a term corresponding to rheumatic fever and rheumatoid arthritis. Interestingly, the barks of Liriodendron chinense (Hemsl.) Sarg was also found in folk to treat ...
DOI:
10.1016/j.jep.2020.113278

15. Kanglaite enhances the efficacy of cisplatin in suppression of hepatocellular carcinoma via inhibiting CKLF1 mediated NF-κB pathway and regulating transporter mediated drug efflux

Author:
Chen, Chen; Ai, Qi-di; Wei, Yu-hui
Source:
Journal of ethnopharmacology 2021 v.264 pp. 113388
ISSN:
0378-8741
Subject:
Coix lacryma-jobi; Western blotting; cell viability; cisplatin; drug therapy; fluorescent antibody technique; gene overexpression; genes; hepatoma; human cell lines; inflammation; interleukin-1beta; models; neoplasm cells; neoplasm progression; quantitative polymerase chain reaction; radiotherapy; staining; synergism; tissue repair; traditional medicine; transcription factor NF-kappa B; transporters; tumor necrosis factor-alpha
Abstract:
... Kanglaite (KLT) is an active extract of the Coix lacryma-jobi seed, which can benefit Qi and nourish Yin, and disperse the accumulation of evils. It is used as a biphasic broad-spectrum anti-cancer drug, and shows synergistic effects with radiotherapy and chemotherapy. However, the mechanism of KLT combined with cisplatin (CDDP) against hepatocellular carcinoma (HCC) has not been elucidated.The ai ...
DOI:
10.1016/j.jep.2020.113388

16. Kuijieling decoction suppresses NLRP3-Mediated pyroptosis to alleviate inflammation and experimental colitis in vivo and in vitro

Author:
Jie, Fengming; Xiao, Suting; Qiao, Yang; You, Yihui; Feng, Yuan; Long, Yu; Li, Sixin; Wu, Yanli; Li, Yanwu; Du, Qun
Source:
Journal of ethnopharmacology 2021 v.264 pp. 113243
ISSN:
0378-8741
Subject:
Western blotting; amino acid sequences; animal models; autoimmune diseases; blood serum; caspase-1; cell culture; colon; colorectal neoplasms; dextran sulfate; enzyme-linked immunosorbent assay; fluorescent antibody technique; immunohistochemistry; inflammation; interleukin-18; interleukin-1beta; messenger RNA; mice; morbidity; mortality; protein content; protein synthesis; pyroptosis; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; staining; traditional medicine; ulcerative colitis
Abstract:
... Ulcerative colitis (UC) is an autoimmune disease. Although the mortality rate of UC is not very high, it has a considerable morbidity rate and an unsatisfactory cure rate. Without effective treatment, UC is likely to develop into colon cancer. Kuijieling (KJL) is an effective empirical formula to treat UC in the clinical setting, and it has been proven to have curative effects against UC.In a prev ...
DOI:
10.1016/j.jep.2020.113243

17. Lophatherum gracile Brongn. attenuates neutrophilic inflammation through inhibition of JNK and calcium

Author:
Lai, Kuei-Hung; Chen, Po-Jen; Chen, Chih-Chuan; Yang, Sien-Hung; El-Shazly, Mohamed; Chang, Yu-Chia; Wu, Yi-Hsuan; Wu, Yi-Hsiu; Wang, Yi-Hsuan; Hsieh, Hsi-Lung; Hwang, Tsong-Long
Source:
Journal of ethnopharmacology 2021 v.264 pp. 113224
ISSN:
0378-8741
Subject:
Western blotting; adhesion; anti-inflammatory activity; calcium; chemotaxis; elastase; enzyme inhibition; enzyme inhibitors; heat; herbal medicines; human cell lines; humans; inflammation; mitogen-activated protein kinase; neutrophils; non-specific serine/threonine protein kinase; phosphorylation; signal transduction; spectroscopy; superoxide anion; traditional medicine
Abstract:
... Lophatherum gracile Brongn. (L. gracile) has been long used in traditional herbal medicine to clinically clear heat, disinhibit dampness, and treat inflammation. However, the effect of L. gracile on the activation of human neutrophils remains unclear.The aim of current study is to investigate the anti-inflammatory properties of L. gracile extract (LGE) in N-formyl-methionyl-leucyl-phenylalanine (f ...
DOI:
10.1016/j.jep.2020.113224

18. Repair function of essential oil from Crocodylus Siamensis (Schneider, 1801) on the burn wound healing via up-regulated growth factor expression and anti-inflammatory effect

Author:
Li, Hua-Liang; Liu, Xiao-Tian; Huang, Shao-Min; Xiong, You-Xiong; Zhang, Zi-Ran; Zheng, Ya-Hui; Chen, Qing-Xi; Chen, Qiong-Hua
Source:
Journal of ethnopharmacology 2021 v.264 pp. 113286
ISSN:
0378-8741
Subject:
Crocodylus siamensis; Western blotting; anti-inflammatory activity; burns (injuries); collagen; crocodiles; dermis; enzyme-linked immunosorbent assay; essential oils; immunohistochemistry; interleukin-1beta; interleukin-6; melanin; messenger RNA; mitogen-activated protein kinase; nitric oxide; oils; phosphorylation; proliferating cell nuclear antigen; rats; staining; tissue repair; traditional medicine; transforming growth factor beta 1; transmission electron microscopy; tumor necrosis factor-alpha; ultrastructure
Abstract:
... Crocodile oil has been used by traditional physicians around the world to treat wound healing and inflammation. However, the scientific rationale and mechanism behind its use in vivo has not been fully researched.We mainly investigated the mechanism during crocodile oil treatment of up-regulated growth factor expression and anti-inflammatory on burn wound healing in rats.The moisture and nitric ox ...
DOI:
10.1016/j.jep.2020.113286

19. San Wu Huangqin decoction regulates inflammation and immune dysfunction induced by influenza virus by regulating the NF-κB signaling pathway in H1N1-infected mice

Author:
Ma, Qin-hai; Ren, Meng-yue; Luo, Jia-bo
Source:
Journal of ethnopharmacology 2021 v.264 pp. 112800
ISSN:
0378-8741
Subject:
B-lymphocytes; CD4-positive T-lymphocytes; IKappaB kinase; Influenza A virus; Rehmannia glutinosa; Scutellaria baicalensis; Sophora flavescens; Western blotting; animal models; blood serum; cytotoxicity; fever; immune response; immunohistochemistry; inflammation; interferon-gamma; interleukin-1beta; interleukin-4; interleukin-6; lungs; macrophages; mice; natural killer cells; protein synthesis; signal transduction; traditional medicine; transcription factor NF-kappa B; tubers; tumor necrosis factor-alpha
Abstract:
... The San Wu Huangqin Decoction (SWHD), which is made from the dried root of Sophora flavescens Aiton (Kushen in Chinese), the dried root of Scutellaria baicalensis Georgi (Huangqin in Chinese), and the dried root tuber of Rehmannia glutinosa (Gaertn.) DC. (Dihuang in Chinese), is a traditional Chinese formula used to treat prolonged fever and inflammatory diseases in clinics and proven to inhibit i ...
DOI:
10.1016/j.jep.2020.112800

20. TMT-based proteomics analysis reveals the efficacy of jiangzhuo formula in improving the lipid profiles of dyslipidemia rats

Author:
Pan, Linlin; Tian, Yuan; Sun, Haiyang; Wang, Yao; Liu, Guirong
Source:
Journal of ethnopharmacology 2021 v.264 pp. 113390
ISSN:
0378-8741
Subject:
Western blotting; apolipoprotein B; apolipoprotein E; bile secretion; blood lipids; blood serum; cholesterol; cholesterol metabolism; drugs; gene expression regulation; gene ontology; genes; high fat diet; hydroxymethylglutaryl-CoA synthase; hyperlipidemia; lipid composition; liquid chromatography; liver; mass spectrometry; peroxisome proliferator-activated receptors; polymerase chain reaction; protein synthesis; protein-protein interactions; proteomics; rats; signal transduction; staining; traditional medicine
Abstract:
... Jiangzhuo Formula (JZF) is a traditional Chinese herbal prescription that is clinically applied to treat dyslipidemia. However, the mechanism underlying its efficacy remains unexplored.This study aims to elucidate the underlying mechanisms, explore potential pathways, and identify the key proteins of JZF for the treatment of dyslipidemia.In this work, Q-Orbitrap high-resolution liquid chromatograp ...
DOI:
10.1016/j.jep.2020.113390