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- Stevenson, Clare
E. M., et al. Show all 10 Authors
- Biochemistry 2014 v.53 no.15 pp. 2494-2504
- Mycobacterium tuberculosis; Streptomyces coelicolor; X-radiation; biochemical pathways; crystallography; glycosides; mass spectrometry; proteins; site-directed mutagenesis; structure-activity relationships
- ... GlgE (EC 220.127.116.11) is an α-maltose 1-phosphate:(1→4)-α-d-glucan 4-α-d-maltosyltransferase of the CAZy glycoside hydrolase 13_3 family. It is the defining enzyme of a bacterial α-glucan biosynthetic pathway and is a genetically validated anti-tuberculosis target. It catalyzes the α-retaining transfer of maltosyl units from α-maltose 1-phosphate to maltooligosaccharides and is predicted to use a do ...
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