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acetylcholinesterase
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Leucojum aestivum
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- Author:
- Liliya Georgievaa; Strahil Berkov; Violeta Kondakova; Jaume Bastida; Francesc Viladomat; Atanas Atanassov; Carles Codina
- Source:
- Zeitschrift für Naturforschung 2014 v.62 no.9-10 pp. 627-635
- ISSN:
- 1865-7125
- Subject:
- Alzheimer disease; Leucojum aestivum; acetylcholinesterase; bulbs; gas chromatography-mass spectrometry; lycorine; summer; Bulgaria
- Abstract:
- ... Leucojum aestivum (summer snowflake) is a plant species used for the extraction of galanthamine, an acetylcholinesterase inhibitor for the treatment of Alzheimer’s disease. Extracts from bulbs collected from 18 Bulgarian populations and from shoot-clumps obtained in vitro from 8 different populations showed variations in their alkaloid composition. Nineteen alkaloids were detected in the studied s ...
- DOI:
- 10.1515/znc-2007-9-1002
- https://doi.org/10.1515/znc-2007-9-1002
2. Analysis of galanthamine-type alkaloids by capillary gas chromatography-mass spectrometry in plants
- Author:
- Berkov, Strahil; Bastida, Jaume; Viladomat, Francesc; Codina, Carles
- Source:
- Phytochemical analysis 2008 v.19 no.4 pp. 285-293
- ISSN:
- 0958-0344
- Subject:
- Leucojum aestivum; Zephyranthes; Galanthus elwesii; Liliaceae; chemical constituents of plants; alkaloids; phytochemicals; cholinesterase inhibitors; acetylcholinesterase; chemical analysis; quantitative analysis; spectral analysis; mass spectrometry; capillary gas chromatography
- Abstract:
- ... Galanthamine, an acetylcholinesterase inhibitor used for the treatment of Alzheimer's disease, and galanthamine-type alkaloids are synthesised in different plants of the family Amaryllidaceae. A capillary gas chromatographic-mass spectroscopic (CGC-MS) method for the separation of 7 galanthamine type alkaloids, including galanthamine and epigalanthamine, is described in the present paper. A simple ...
- DOI:
- 10.1002/pca.1028
- PubMed:
- 18438759
- https://doi.org/10.1002/pca.1028
- Author:
- Strahil Berkov; Jaume Bastida; Francesc Viladomat; Carles Codina
- Source:
- Talanta 2011 v.83 no.5 pp. 1455-1465
- ISSN:
- 0039-9140
- Subject:
- Alzheimer disease; Leucojum aestivum; Narcissus; acetylcholinesterase; bulbs; gas chromatography-mass spectrometry; high performance liquid chromatography; leaves; metabolomics; methanol; nuclear magnetic resonance spectroscopy; pharmaceutical industry; principal component analysis; quality control; rapid methods; raw materials
- Abstract:
- ... Galanthamine, an acetylcholinesterase inhibitor marketed as a hydrobromide salt for the treatment of Alzheimer's disease, is obtained from some Amaryllidaceae plants. A new method was developed and validated for its quantification by GC–MS in different plant sources: bulbs and leaves from Narcissus confusus; bulbs from N. pseudonarcissus cv. Carlton; and leaves and in vitro cultures from L. aestiv ...
- DOI:
- 10.1016/j.talanta.2010.11.029
- https://doi.org/10.1016/j.talanta.2010.11.029
- Author:
- Diop, M. F.; Hehn, A.; Ptak, A.; Chrétien, F.; Doerper, S.; Gontier, E.; Bourgaud, F.; Henry, M.; Chapleur, Y.; Laurain-Mattar, D.
- Source:
- Phytochemistry reviews 2007 v.6 no.1 pp. 137-141
- ISSN:
- 1568-7767
- Subject:
- Alzheimer disease; Leucojum aestivum; Rhizobium rhizogenes; acetylcholinesterase; alkaloids; cell differentiation; growth regulators; metabolites; morphogenesis; roots; tissue culture
- Abstract:
- ... Galanthamine, an isoquinoline alkaloid acetylcholinesterase inhibitor, is an important agent used all around the world for the symptomatic treatment of senile dementia of the Alzheimer's type. The production of this metabolite and the availability of the plant are limited and prompted the search for an alternative way to obtain this valuable metabolite using in vitro cultures of Leucojum aestivum ...
- DOI:
- 10.1007/s11101-006-9043-z
- https://doi.org/10.1007/s11101-006-9043-z
5. LCMS and GCMS for the Screening of Alkaloids in Natural and in Vitro Extracts of Leucojum aestivum
- Author:
- Ptak, Agata; El Tahchy, Anna; Dupire, Francois; Boisbrun, Michel; Henry, Max; Chapleur, Yves; Mos, Maria; Laurain-Mattar, Dominique
- Source:
- Journal of natural products 2009 v.72 no.1 pp. 142-147
- ISSN:
- 0163-3864
- Subject:
- Leucojum aestivum; ethylene; acetylcholinesterase; isoquinoline alkaloids; chemical analysis; high performance liquid chromatography; somatic embryogenesis; mass spectrometry; cholinesterase inhibitors; callus culture; gas chromatography; lycorine; somatic embryos
- DOI:
- 10.1021/np800585c
- PubMed:
- 19117485
- https://doi.org/10.1021/np800585c
- Author:
- Berkov, Strahil; Bastida, Jaume; Nikolova, Milena; Viladomat, Francesc; Codina, Carles
- Source:
- Phytochemical analysis 2008 v.19 no.5 pp. 411-419
- ISSN:
- 0958-0344
- Subject:
- cholinesterase inhibitors; mass spectrometry; Zephyranthes; Galanthus nivalis; acetylcholinesterase; alkaloids; Fumaria officinalis; Chelidonium majus; Glaucium flavum; enzyme inhibition; Corydalis solida; Pancratium maritimum; Liliaceae; chemical structure; Leucojum aestivum; Galanthus elwesii; Fumaria vaillantii; Sternbergia; gas chromatography; thin layer chromatography
- Abstract:
- ... Alkaloid extracts from 12 plant species of the families Amaryllidaceae, Fumariacae and Papaveraceae were studied with respect to their acetylcholinesterase inhibitory activity and alkaloid patterns. Fifty-three alkaloids were identified by GC-MS, including known acetylcholinesterase (AChE) inhibitors such as galanthamine, epigalanthamine, sanguinine and epinorgalanthamine in extracts of Amaryllida ...
- DOI:
- 10.1002/pca.1066
- https://doi.org/10.1002/pca.1066
- Author:
- Strahil Berkov; Lilija Georgieva; Violeta Kondakova; Francesc Viladomat; Jaume Bastida; Atanas Atanassov; Carles Codina
- Source:
- Biochemical systematics and ecology 2013 v.46 pp. 152-161
- ISSN:
- 0305-1978
- Subject:
- Alzheimer disease; Leucojum aestivum; acetylcholinesterase; biosynthesis; chemotypes; gas chromatography; lycorine; mass spectrometry; medicine; mountains; Balearic Islands; Bulgaria; Danube River
- Abstract:
- ... Leucojum aestivum, an industrial source of the acetylcholinesterase inhibitor galanthamine, shows a great chemodiversity in its alkaloid synthesis. Samples from various geographically distinct populations from Bulgaria and the Balearic Islands were studied by GC–MS. The alkaloid pattern of the plants of L. aestivum (subsp. pulchellum) from the Balearic Islands were dominated by crinine type compou ...
- DOI:
- 10.1016/j.bse.2012.10.002
- https://doi.org/10.1016/j.bse.2012.10.002
- Author:
- Borislav Georgiev; Milena Nikolova; Ina Aneva; Anatoli Dzhurmanski; Boriana Sidjimova; Strahil Berkov
- Source:
- BioRisk 2022 v.17 pp. 309-315
- ISSN:
- 1313-2652
- Subject:
- Asteraceae; Brassicaceae; Leucojum aestivum; Monarda fistulosa; Satureja pilosa; acetylcholinesterase; alkaloids; carvacrol; death; insect control; insecticidal properties; toxicity
- Abstract:
- ... AbstractAcetylcholinesterase (AChE) inhibitors are widely used in Alzheimer’s treatment, but they are also crucial for their action on organophosphorus insecticides. The latter exert their toxicity by inhibiting the AChE enzyme in insects, leading to their death. Amaryllidaceae alkaloids have been proven to be potent AChE inhibitors. In the present study methanolic extracts and essential oils bei ...
- DOI:
- 10.3897/biorisk.17.77052
- https://doi.org/10.3897/biorisk.17.77052