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- Ohtsuki, Yuya, et al. Show all 6 Authors
- Biochemical and biophysical research communications 2017
- acetaminophen; acetylcysteine; benzoquinones; chemical structure; cytochrome P-450; drug interactions; glutathione; messenger RNA; metabolites; protein degradation; transcription (genetics)
- ... Cytochrome P450 (CYP) 3A subfamily members are known to metabolize various types of drugs, highlighting the importance of understanding drug–drug interactions (DDI) depending on CYP3A induction or inhibition. While transcriptional regulation of CYP3A members is widely understood, post-translational regulation needs to be elucidated. We previously reported that acetaminophen (APAP) induces CYP3A ac ...