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You searched for: Subject term adaptive immunity Remove constraint Subject term: adaptive immunity Text Availability Citation in PubAg Remove constraint Text Availability: Citation in PubAg
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1. Novel model for chronic intestinal inflammation in chickens: (2) Immunologic mechanism behind the inflammatory response

Author:
Gabriela Cardoso Dal Pont; A. Lee; C. Bortoluzzi; Y.Z. Farnell; C. Gougoulias; M.H. Kogut
Source:
Developmental and comparative immunology 2023 v.138 no. pp. 104524
ISSN:
0145-305X
Subject:
T-lymphocytes; adaptive immunity; broiler chickens; chemokines; diet; histology; ileum; inflammation; interferon-alpha; interleukin-10; interleukin-21; interleukin-6; jejunum; models; monocytes; polysaccharides; vascular endothelial growth factors
Abstract:
... Intestinal inflammation in poultry is a complex response that involves immune and intestinal cells which is still not fully understood. Thus, to better understand the mechanisms that drive the chronic intestinal inflammation in fowl we conducted an experiment applying a previously established nutritional model of low-grade chronic intestinal inflammation to evaluate cytokine and chemokine profiles ...
DOI:
10.1016/j.dci.2022.104524

2. 3D microenvironment attenuates simulated microgravity-mediated changes in T cell transcriptome

Author:
Mei ElGindi; Jiranuwat Sapudom; Praveen Laws; Anna Garcia-Sabaté; Mohammed F. Daqaq; Jeremy Teo
Source:
Cellular and molecular life sciences 2022 v.79 no.9 pp. 508
ISSN:
1420-682X
Subject:
T-lymphocytes; adaptive immunity; blood circulation; cell culture; collagen; human physiology; humans; microgravity; space flight; transcriptome; travel
Abstract:
... Human space travel and exploration are of interest to both the industrial and scientific community. However, there are many adverse effects of spaceflight on human physiology. In particular, there is a lack of understanding of the extent to which microgravity affects the immune system. T cells, key players of the adaptive immune system and long-term immunity, are present not only in blood circulat ...
DOI:
10.1007/s00018-022-04531-8

3. A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-κB signaling in activated T cells

Author:
Hongli Yin; Ozge Karayel; Ying-Yin Chao; Thomas Seeholzer; Isabel Hamp; Oliver Plettenburg; Torben Gehring; Christina Zielinski; Matthias Mann; Daniel Krappmann
Source:
Cellular and molecular life sciences 2022 v.79 no.2 pp. 112
ISSN:
1420-682X
Subject:
T-lymphocytes; adaptive immunity; homeostasis; humans; mass spectrometry; proteinases; signalosome; ubiquitin; zinc finger motif
Abstract:
... T cell activation initiates protective adaptive immunity, but counterbalancing mechanisms are critical to prevent overshooting responses and to maintain immune homeostasis. The CARD11-BCL10-MALT1 (CBM) complex bridges T cell receptor engagement to NF-κB signaling and MALT1 protease activation. Here, we show that ABIN-1 is modulating the suppressive function of A20 in T cells. Using quantitative ma ...
DOI:
10.1007/s00018-022-04154-z

4. AIF-1 and RNASET2 are involved in the inflammatory response in the Mediterranean mussel Mytilus galloprovincialis following Vibrio infection

Author:
M.G. Parisi; N. Baranzini; M. Dara; C. La Corte; J. Vizioli; M. Cammarata
Source:
Fish & shellfish immunology 2022 v.127 pp. 109-118
ISSN:
1050-4648
Subject:
Mytilus galloprovincialis; Vibrio splendidus; adaptive immunity; allografting; antibodies; aquaculture; bacterial infections; fish; hemocytes; histology; immune response; inflammation; macrophages; mussels; pathogens; ribonucleases; shellfish
Abstract:
... Filter-feeding bivalves, such as the Mytilus species, are exposed to different types of bacteria in the surrounding waters, in particular of the Vibrio genus. Mussels lack an adaptive immune system and hemocytes can recognize pathogen-associated molecular patterns (PAMPs) via pattern recognition receptors (PRRs) to activate intracellular signaling pathways to trigger the antimicrobial effectors sy ...
DOI:
10.1016/j.fsi.2022.06.010

5. APOBEC3, TRIM5α, and BST2 polymorphisms in healthy individuals of various populations with special references to its impact on HIV transmission

Author:
HariOm Singh; Sushama Jadhav; Abdul Arif Khan; Shubham K. Aggarwal; Ranjana Choudhari; Sheetal Verma; Sumit Aggarwal; Vivek Gupta; Amita Singh; Sumitra Nain; Harjeet Singh Maan
Source:
Microbial pathogenesis 2022 v.162 pp. 105326
ISSN:
0882-4010
Subject:
adaptive immunity; cytokines; disease progression; gene expression regulation; genetic polymorphism; humans; inflammation; pathogenesis
Abstract:
... AIDS restriction genes (ARGs) like APOBEC3, TRIM5α, and BST2 can act as immunological detectors of the innate protective mechanism of the body. ARGs influence the course of viral pathogenesis and progression of the disease. The infection caused by different viruses including HIV activates the innate immune receptors leading to production of proinflammatory cytokines, interferons and signals that r ...
DOI:
10.1016/j.micpath.2021.105326

6. Adaptive Immune Responses, Immune Escape and Immune-Mediated Pathogenesis during HDV Infection

Author:
Valerie Oberhardt; Maike Hofmann; Robert Thimme; Christoph Neumann-Haefelin
Source:
Viruses 2022 v.14 no.2 pp. -
ISSN:
1999-4915
Subject:
CD8-positive T-lymphocytes; HLA antigens; Hepatitis B virus; Hepatitis C virus; Hepatitis delta virus; Human immunodeficiency virus; adaptive immunity; humans; interferons; liver cirrhosis; mixed infection; pathogenesis; satellite viruses; vertebrate viruses
Abstract:
... The hepatitis delta virus (HDV) is the smallest known human virus, yet it causes great harm to patients co-infected with hepatitis B virus (HBV). As a satellite virus of HBV, HDV requires the surface antigen of HBV (HBsAg) for sufficient viral packaging and spread. The special circumstance of co-infection, albeit only one partner depends on the other, raises many virological, immunological, and pa ...
DOI:
10.3390/v14020198

7. Adaptive immune response ranking is associated with reproductive phenotypes in grazing dairy cows divergent in genetic merit for fertility traits

Author:
T.M. Grala; B. Kuhn-Sherlock; M.A. Crookenden; C.G. Walker; J.R. Roche; M.D. Price; C.R. Burke; S. Meier
Source:
Journal of dairy science 2022 v.105 no.6 pp. 5519-5533
ISSN:
0022-0302
Subject:
Holstein; adaptive immunity; confidence interval; dairy science; estrus; genetic merit; lactation; ovulation; pastures; puberty; weight gain
Abstract:
... A strong adaptive immune response has been reported to have positive effects on fertility; therefore, we investigated antibody- and cell-mediated adaptive immune responses (AMIR and CMIR, respectively) and their associations with reproductive phenotypes using a population of animals that differed in their estimated genetic merit for fertility traits (fertility breeding value; FertBV). Holstein-Fri ...
DOI:
10.3168/jds.2021-21538

8. Age and episode‐associated occurrence of Cryptosporidium species and subtypes in a birth‐cohort of dairy calves

Author:
Suhui Hu; Muchun Wan; Wanyi Huang; Weijian Wang; Ruobing Liang; Dongle Su; Na Li; Lihua Xiao; Yaoyu Feng; Yaqiong Guo
Source:
Transboundary and emerging diseases 2022 v.69 no.5 pp. e1710
ISSN:
1865-1674
Subject:
Cryptosporidium parvum; adaptive immunity; cohort studies; cross-sectional studies; cryptosporidiosis; dairy cattle; diarrhea; farms; genome; genotyping; models; natural history; oocysts
Abstract:
... The role of species‐specific immunity in infection patterns of Cryptosporidium spp. in humans and farm animals is not well understood. In the present study, the dynamics of Cryptosporidium infections in a natural cryptosporidiosis model was examined using genotyping, subtyping and whole genome sequencing tools. In a cross‐sectional survey of Cryptosporidium spp. in 934 dairy cattle on one farm, ma ...
DOI:
10.1111/tbed.14507

9. Age matters: Differential effects of the exposure to elevated environmental temperatures on representative variables of the immune system in juvenile and adult female Japanese quail.

Author:
Emiliano A. Videla; Stefano M. Tortone; Raul H. Marin; F. Nicolas Nazar
Source:
Journal of thermal biology 2022 v.107 pp. 103257
ISSN:
0306-4565
Subject:
Coturnix japonica; adaptive immunity; adults; ambient temperature; antibody formation; antigens; females; heat; heat stress; heterophils; inflammation; juveniles; mitogens; poultry
Abstract:
... Several days under the influence of high environmental temperature negatively impact on some immune-related variables of poultry species. However, it is little known whether this exposure affects differentially the immune response on different life stages. This study was aimed at characterizing the immune responses of juvenile and adult female Japanese quail (Coturnix coturnix) when exposed to a c ...
DOI:
10.1016/j.jtherbio.2022.103257

10. Analysis of CRISPR–Cas system and antimicrobial resistance in Staphylococcus coagulans isolates

Author:
A.C. Murugesan; H.S. Varughese
Source:
Letters in applied microbiology 2022 v.75 no.1 pp. 126-134
ISSN:
0266-8254
Subject:
Archaea; CRISPR-Cas systems; adaptive immunity; antibiotic resistance; bacteriophages; horizontal gene transfer; methicillin; plasmids; Antarctica
Abstract:
... CRISPR–Cas system contributes adaptive immunity to protect the bacterial and archaeal genome against invading mobile genetic elements. In this study, an attempt was made to characterize the CRISPR–Cas system in Staphylococcus coagulans, the second most prevalent coagulase positive staphylococci causing skin infections in dogs. Out of 45 S. coagulans isolates, 42/45 (93·33%) strains contained CRISP ...
DOI:
10.1111/lam.13713

11. Anti-CRISPR proteins as a therapeutic agent against drug-resistant bacteria

Author:
Pallavi Vyas; Harish
Source:
Microbiological research 2022 v.257 no. pp. 126963
ISSN:
0944-5013
Subject:
CRISPR-Cas systems; adaptive immunity; bacteriophages; evolution; growth retardation; health services; mechanism of action; multiple drug resistance; nucleoproteins; public health; research; therapeutics
Abstract:
... The continuous deployment of various antibiotics to treat multiple serious bacterial infections leads to multidrug resistance among the bacterial population. It has failed the standard treatment strategies through different antibacterial agents and serves as a significant threat to public health worldwide at devastating levels. The discovery of anti-CRISPR proteins catches the interest of research ...
DOI:
10.1016/j.micres.2022.126963

12. Anti-Toxoplasma host defense systems and the parasitic counterdefense mechanisms

Author:
Miwa Sasai; Masahiro Yamamoto
Source:
Parasitology international 2022 v.89 pp. 102593
ISSN:
1383-5769
Subject:
Toxoplasma gondii; adaptive immunity; cytokines; gene expression; human population; immune system; interferon-gamma; parasites; parasitology; rhoptry
Abstract:
... Toxoplasma gondii is an intracellular parasite that does not differentiate among hosts and is capable of infecting nearly all warm-blooded vertebrates. Although about 30% of the human population is thought to be infected with T. gondii, it is one of the most common opportunistic infections that does not cause serious symptoms when the immune system is functioning normally. In this review, we focus ...
DOI:
10.1016/j.parint.2022.102593

13. Anticipated pharmacological role of Aviptadil on COVID-19

Author:
Tuhin Mukherjee; Tapan Behl; Sanchay Sharma; Aayush Sehgal; Sukhbir Singh; Neelam Sharma; Bijo Mathew; Jasleen Kaur; Ratandeep Kaur; Mayukh Das; Lotfi Aleya; Simona Bungau
Source:
Environmental science and pollution research 2022 v.29 no.6 pp. 8109-8125
ISSN:
0944-1344
Subject:
COVID-19 infection; Food and Drug Administration; Severe acute respiratory syndrome coronavirus 2; acute respiratory distress syndrome; adaptive immunity; anti-inflammatory activity; homeostasis; humans; hypertension; patents; pollution; pulmonary artery; research; vasoactive intestinal peptide
Abstract:
... Vasoactive intestinal peptide (VIP) is a neuropeptide that is produced by the lymphoid cells and plays a major role in immunological functions for controlling the homeostasis of the immune system. VIP has been identified as a potent anti-inflammatory factor, in boosting both innate and adaptive immunity. Since December 2019, SARS‐Cov‐2 was found responsible for the disease COVID‐19 which has sprea ...
DOI:
10.1007/s11356-021-17824-5

14. Antimicrobial peptides from freshwater invertebrate species: potential for future applications

Author:
Robert Egessa
Source:
Molecular biology reports 2022 v.49 no.10 pp. 9797-9811
ISSN:
0301-4851
Subject:
Annelida; Cnidaria; adaptive immunity; animal husbandry; aquaculture; crustin; food industry; freshwater; innate immunity; invertebrates; medicine; molecular biology
Abstract:
... Invertebrates are a significant source of antimicrobial peptides because they lack an adaptive immune system and must rely on their innate immunity to survive in a pathogen-infested environment. Various antimicrobial peptides that represent major components of invertebrate innate immunity have been described in a number of investigations over the last few decades. In freshwater invertebrates, anti ...
DOI:
10.1007/s11033-022-07483-1

15. Antiviral Activities of Group I Innate Lymphoid Cells

Author:
Ramon A. Lujan; Sophia M. Vrba; Heather D. Hickman
Source:
Journal of molecular biology 2022 v.434 no.6 pp. 167266
ISSN:
0022-2836
Subject:
adaptive immunity; cytokines; molecular biology; virus replication
Abstract:
... Even before the adaptive immune response initiates, a potent group of innate antiviral cells responds to a wide range of viruses to limit replication and virus-induced pathology. Belonging to a broader family of recently discovered innate lymphoid cells (ILCs), antiviral group I ILCs are composed of conventional natural killer cells (cNK) and tissue-resident ILCs (ILC1s) that can be distinguished ...
DOI:
10.1016/j.jmb.2021.167266

16. Applications of CRISPR/Cas9 technology for modification of the plant genome

Author:
Sohini Deb; Amrita Choudhury; Banridor Kharbyngar; Rama Rao Satyawada
Source:
Genetica 2022 v.150 no.1 pp. 1-12
ISSN:
0016-6707
Subject:
CRISPR-Cas systems; CRISPR-associated endonuclease 9; DNA; adaptive immunity; biosafety; genes
Abstract:
... The CRISPR/Cas (Clustered regularly interspaced short palindromic repeats/ CRISPR associated protein 9) system was discovered in bacteria and archea as an acquired immune response to protect the cells from infection. This technology has now evolved to become an efficient genome editing tool, and is replacing older gene editing technologies. This technique uses programmable sgRNAs to guide the Cas9 ...
DOI:
10.1007/s10709-021-00146-2

17. Arthrospira Enhances Seroclearance in Patients with Chronic Hepatitis B Receiving Nucleos(t)ide Analogue through Modulation of TNF-α/IFN-γ Profile

Author:
Sheng-Jie Shiue; Chao-Ling Cheng; Han-Shiang Shiue; Chun-Nan Chen; Sheng-Wei Cheng; Li-Wei Wu; Ganbolor Jargalsaikhan; Tze-Sian Chan; Hsin-Yi Lin; Ming-Shun Wu
Source:
Nutrients 2022 v.14 no.14 pp. -
ISSN:
2072-6643
Subject:
Arthrospira; B-lymphocytes; DNA; T-lymphocytes; adaptive immunity; chronic hepatitis B; cytotoxicity; hepatitis B antigens; hepatoma; immune response; immunosuppression; interferon-gamma; interleukin-2; interleukin-6; liver cirrhosis; therapeutics; viruses
Abstract:
... Chronic hepatitis B (CHB) virus infection, causing immune dysfunction and chronic hepatitis, is one of the leading risk factors for hepatocellular cancer. We investigated how Arthrospira affected hepatitis B surface antigen (HBsAg) reduction in CHB patients under continued nucleos(t)ide analogues (NA). Sixty CHB patients who had been receiving NA for at least one year with undetectable HBV DNA wer ...
DOI:
10.3390/nu14142790

18. Assembly of Cas7 subunits of Leptospira on the mature crRNA of CRISPR-Cas I-B is modulated by divalent ions

Author:
Md Saddam Hussain; Manish Kumar
Source:
Gene 2022 v.818 pp. 146244
ISSN:
0378-1119
Subject:
CRISPR-Cas systems; DNA; Leptospira interrogans serovar Copenhageni; RNA; adaptive immunity; electron microscopy; fluorescence emission spectroscopy; gel chromatography; genes; pH; prokaryotic cells; ribonucleases; ribonucleoproteins; serotypes; temperature
Abstract:
... The spirochete Leptospira interrogans serovar Copenhageni harbors the genetic elements of the CRISPR-Cas type I-B system in its genome. CRISPR-Cas is a CRISPR RNA (crRNA) mediated adaptive immune system in most prokaryotes against mobile genetic elements (MGEs). To eliminate the intruding MGEs, CRISPR-Cas type I systems utilize a Cascade (CRISPR-associated complex for antiviral defense) complex co ...
DOI:
10.1016/j.gene.2022.146244

19. Associations between MHC class II variation and phenotypic traits in a free‐living sheep population

Author:
Wei Huang; Kara L. Dicks; Keith T. Ballingall; Susan E. Johnston; Alexandra M. Sparks; Kathryn Watt; Jill G. Pilkington; Josephine M. Pemberton
Source:
Molecular ecology 2022 v.31 no.3 pp. 902-915
ISSN:
0962-1083
Subject:
Teladorsagia circumcincta; adaptive immunity; allelic variation; body weight; fecal egg count; gastrointestinal nematodes; major histocompatibility complex; pathogens; phenotype; sheep
Abstract:
... Pathogen‐mediated selection (PMS) is thought to maintain the high level of allelic diversity observed in the major histocompatibility complex (MHC) class II genes. A comprehensive way to demonstrate contemporary selection is to examine associations between MHC variation and individual fitness. As individual fitness is hard to measure, many studies examine associations between MHC variation and phe ...
DOI:
10.1111/mec.16265

20. Attenuated T cell activation and rearrangement of T cell receptor β repertoire in silica nanoparticle-induced pulmonary fibrosis of mice

Author:
Lei Bao; Zihan Geng; Juan Wang; Liyi He; Aijuan Kang; Jianshi Song; Xiaoyan Huang; Yaling Zhang; Qingping Liu; Tao Jiang; Yaxian Pang; Yujie Niu; Rong Zhang
Source:
Environmental research 2022 v.213 pp. 113678
ISSN:
0013-9351
Subject:
adaptive immunity; coculture; genes; immune response; lungs; macrophages; mice; pulmonary fibrosis; research; silica
Abstract:
... Silica nanoparticles (SiNPs) cause pulmonary fibrosis through a complex immune response, but the underlying mechanisms by which SiNPs interact with T cells and affect their functions remain unclear. The T cell receptor (TCR) repertoire is closely related to T cell activation and proliferation and mediates innate and adaptive immunity. High-throughput sequencing of the TCR enables comprehensive mon ...
DOI:
10.1016/j.envres.2022.113678