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- Hempel, Nadine, et al. Show all 8 Authors
- Molecular cell 2016 v.62 no.4 pp. 520-531
- adenosine triphosphate; apoptosis; carcinogenesis; genes; guanosine triphosphate; mitochondria; neoplasms; neurodegenerative diseases; transcription (genetics); transforming growth factor beta
- ... Smads are nuclear-shuttling transcriptional mediators of transforming growth factor-β (TGF-β) signaling. Although their essential nuclear roles in gene regulation during development and carcinogenesis are well established, whether they have important cytoplasmic functions remains unclear. Here we report that Smad2 is a critical determinant of mitochondrial dynamics. We identified mitofusin2 (MFN2) ...
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