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1. Activation of PKB and ERK, but not PI3K, is involved in fucosylated chondroitin sulphate from Acaudina molpadioides induced glucose uptake

Author:
Chen, Ruixi,   et al.   ; Hu, Shiwei; Xu, Hui; Wang, Jingfeng; Li, Zhaojie; Xu, Jiachao;     Show all 6 Authors
Source:
Journal of functional foods 2014 v.10 pp. 385-396
ISSN:
1756-4646
Subject:
Acaudina molpadioides; adipocytes; adipose tissue; blood glucose; chondroitin sulfate; glucose; glucose transporters; hyperglycemia; insulin resistance; mice; mitogen-activated protein kinase; phosphatidylinositol 3-kinase; phosphorylation
Abstract:
... Fucosylated chondroitin sulphate from sea cucumber can mitigate hyperglycaemia. However, the possible mechanism is unclear. We investigated the effects of fucosylated chondroitin sulphate from Acaudina molpadioides (Am-CHS) on glucose uptake and its mechanism using TNF-α-induced 3T3-L1 insulin resistant adipocytes. Results showed that Am-CHS could significantly increase glucose uptake and GLUT4 tr ...
DOI:
10.1016/j.jff.2014.07.002