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- Schwarz, Margrit, et al. Show all 21 Authors
- Molecular and Cellular Endocrinology 2013 v.369 pp. 119-129
- G-protein coupled receptors; agonists; alpha-linolenic acid; corn oil; glucagon-like peptide 1; glucose; insulin secretion; intestines; islets of Langerhans; mechanism of action; mice
- ... FFA1 (GPR40) and GPR120 are G-protein-coupled receptors activated by long-chain fatty acids. FFA1 is expressed in pancreatic β-cells, where it regulates glucose-dependent insulin secretion, and GPR120 has been implicated in mediating GLP-1 secretion. We show here that FFA1 co-localizes with GLP-1 in enteroendocrine cells and plays a critical role in glucose management by mediating GLP-1 secretion ...