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1. Dissection of mechanisms of Chinese medicinal formula Si-Miao-Yong-an decoction protects against cardiac hypertrophy and fibrosis in isoprenaline-induced heart failure

Author:
Zhang, Fengxiang; Zhang, Xue,   et al.   ; Zhao, Yuqian; Jiang, Yingnan; Chen, Yanmei; Zhu, Lingjuan; Yao, Xinsheng;     Show all 7 Authors
Source:
Journal of ethnopharmacology 2020 v.248 pp. 112050
ISSN:
0378-8741
Subject:
Western blotting; active ingredients; agonists; animal models; beta adrenergic receptors; blood serum; cardiac output; cardiomyocytes; echocardiography; endocrine diseases; enzyme-linked immunosorbent assay; fibrosis; fluorescence; fluorescent antibody technique; gangrene; heart failure; hypertrophy; isoprenaline; liquid chromatography; messenger RNA; mitogen-activated protein kinase; pathogenesis; phosphorylation; quantitative polymerase chain reaction; rats; reactive oxygen species; staining; tandem mass spectrometry; traditional medicine; vasculitis
Abstract:
... Si-Miao-Yong-An decoction (SMYAD) is a traditional Chinese herbal formulation. SMYAD first appeared in the Eastern Han Dynasty according to the “Shen Yi Mi Zhuan”. Then the formula was recorded in the “Yan Fang Xin Bian” edited by medical scientist Bao Xiangao in the Qing Dynasty. This well-known prescription has been traditionally used for gangrene and vascular vasculitis. It is mainly used for c ...
DOI:
10.1016/j.jep.2019.112050

2. Decreased H3K9 acetylation level of LXRα mediated dexamethasone-induced placental cholesterol transport dysfunction

Author:
Zhang, Guohui; Zhang, Yuanzhen,   et al.   ; Huang, Wen; Zhou, Jin; Wang, Hui;     Show all 5 Authors
Source:
Biochimica et biophysica acta 2019
ISSN:
1388-1981
Subject:
ABC transporters; acetylation; agonists; birth weight; blood serum; dexamethasone; fetal development; glucocorticoid receptors; growth and development; high density lipoprotein cholesterol; histone deacetylase; human cell lines; humans; laboratory animals; liver; low density lipoprotein cholesterol; low density lipoprotein receptors; rats; small interfering RNA; trophoblast
Abstract:
... Due to the insufficient fetal cholesterol synthesis, maternal cholesterol transport through the placenta becomes an important source of fetal cholesterol pool, which is essential for fetal growth and development. This study aimed to investigate the effects of dexamethasone on fetal cholesterol levels, and explore its placental mechanism. Pregnant Wistar rats were injected subcutaneously with dexam ...
DOI:
10.1016/j.bbalip.2019.158524

3. Rhynchophyllin attenuates neuroinflammation in Tourette syndrome rats via JAK2/STAT3 and NF‐κB pathways

Author:
Mengjiao, Zhang,   et al.   ; Hongyan, Long; Chunyan, Wang; Yaruo, Huang;     Show all 4 Authors
Source:
Environmental toxicology 2019 v.34 no.10 pp. 1114-1120
ISSN:
1520-4081
Subject:
Western blotting; agonists; blood serum; immunohistochemistry; interleukin-1beta; interleukin-6; models; necrosis; neoplasms; non-specific protein-tyrosine kinase; rats; signal transduction; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:
... The aim of this study was designed to investigate the effects of rhynchophyllin (RH) on neuroinflammation in Tourette syndrome (TS) rats. TS model was established in rats by the injection of selective 5‐HT2A/2C agonist 1‐(2, 5‐dimethoxy‐4‐iodophenyl)‐2‐aminopropane (DOI). Behavior in DOI‐induced rats was tested. Inflammatory cytokines levels such as interleukin‐1β (IL‐1β), interleukin‐6 (IL‐6), an ...
DOI:
10.1002/tox.22813

4. Caffeine programs hepatic SIRT1-related cholesterol synthesis and hypercholesterolemia via A2AR/cAMP/PKA pathway in adult male offspring rats

Author:
Zhang, Li,   et al.   ; Hu, Shuwei; Liu, Kexin; Luo, Hanwen; Xu, Dan; Chen, Liaobin; Wang, Hui;     Show all 7 Authors
Source:
Toxicology 2019 v.418 pp. 11-21
ISSN:
0300-483X
Subject:
acetylation; adulthood; adults; agonists; anesthesia; blood serum; cAMP-dependent protein kinase; caffeine; cholesterol; cyclic AMP; epigenetics; forskolin; gene expression; gene expression regulation; genes; histones; hypercholesterolemia; laboratory animals; liver; males; progeny; purinergic receptors; rats; resveratrol
Abstract:
... Clinical and animal studies have indicated that hypercholesterolemia has intrauterine developmental origin. Our previous studies showed that prenatal caffeine exposure (PCE) increased the serum total cholesterol (TCH) levels in adult offspring rats. This study investigates the intrauterine programming mechanism of PCE male offspring rats susceptible to adult hypercholesterolemia. Pregnant Wistar r ...
DOI:
10.1016/j.tox.2019.02.015

5. Identification of a novel function of hepatic long-chain acyl-CoA synthetase-1 (ACSL1) in bile acid synthesis and its regulation by bile acid-activated farnesoid X receptor

Author:
Zhang, Yanqiao,   et al.   ; Singh, Amar Bahadur; Dong, Bin; Xu, Yanyong; Liu, Jingwen;     Show all 5 Authors
Source:
Biochimica et biophysica acta 2019 v.1864 no.3 pp. 358-371
ISSN:
1388-1981
Subject:
Adenoviridae; acute effects; acyl coenzyme A; adipose tissue; adults; agonists; beta oxidation; bile; bile acids; biochemical pathways; biosynthesis; blood serum; cholesterol metabolism; fatty acids; free fatty acids; gene expression regulation; heart; high fat diet; hypercholesterolemia; knockout mutants; liver; long-chain-fatty-acid-CoA ligase; low density lipoprotein cholesterol; low density lipoprotein receptors; messenger RNA; mice; phenotype; phospholipids; protein content; skeletal muscle; triacylglycerols
Abstract:
... Long-chain acyl-CoA synthetase 1 (ACSL1) plays a pivotal role in fatty acid β‑oxidation in heart, adipose tissue and skeletal muscle. However, key functions of ACSL1 in the liver remain largely unknown. We investigated acute effects of hepatic ACSL1 deficiency on lipid metabolism in adult mice under hyperlipidemic and normolipidemic conditions. We knocked down hepatic ACSL1 expression using adenov ...
DOI:
10.1016/j.bbalip.2018.12.012
PubMed:
30580099
PubMed Central:
PMC6604619

6. Impaired vagus function in rats suppresses bile acid synthesis in the liver by disrupting tight junctions and activating Fxr-Fgf15 signaling in the intestine

Author:
Zhang, Youcai,   et al.   ; Wang, Fangyu; Lu, Zhiqiang; Wang, Xue;     Show all 4 Authors
Source:
Biochemical and biophysical research communications 2018 v.495 no.1 pp. 1490-1496
ISSN:
0006-291X
Subject:
agonists; antagonists; bile; bile acids; blood serum; energy; glucose; homeostasis; intestines; lipids; liver; metabolism; nervous system diseases; rats; signal transduction; tight junctions; vagus nerve
Abstract:
... Bile acids (BAs) circulate between the liver and intestine, and regulate the homeostasis of glucose, lipid, and energy. Recent studies demonstrated an essential role of BAs in neurological diseases, suggesting an interaction between BAs and the nervous system. In the present study, we showed that impaired vagus function in rats induced by vagotomy resulted in an increase in bile flow without causi ...
DOI:
10.1016/j.bbrc.2017.11.201

7. FGF21 mediates the protective effect of fenofibrate against acetaminophen -induced hepatotoxicity via activating autophagy in mice

Author:
Zhang, Yi; Zhang, Saisai,   et al.   ; Pan, Yingying; Xiong, Rongrong; Zheng, Jujia; Li, Qianyao; Li, Xiaokun; Pan, Xuebo; Yang, Shulin;     Show all 9 Authors
Source:
Biochemical and biophysical research communications 2018 v.503 no.2 pp. 474-481
ISSN:
0006-291X
Subject:
acetaminophen; agonists; alanine transaminase; aspartate transaminase; autophagy; blood serum; fenofibrate; fibroblast growth factors; hepatocytes; hepatoprotective effect; hepatotoxicity; liver; liver diseases; mice; mitochondria; necrosis; overdose; oxidative stress; peroxisome proliferator-activated receptors
Abstract:
... Overdose of acetaminophen (APAP) induces acute liver injury due in part to destruction of mitochondria and resulted oxidative stress. Recently, FGF21 has been demonstrated to be an endocrine factor to protect liver from oxidative stress. The aim of present study is to explore the role of fibroblast growth factor 21 (FGF21) in the protective effect of fenofibrate, an agonist of peroxisome prolifera ...
DOI:
10.1016/j.bbrc.2018.04.157

8. A potent free fatty acid receptor 1 agonist with a glucose-dependent antihyperglycemic effect

Author:
Zhang, Jikang; Zhang, Yu,   et al.   ; WangThese authors contributed equally to this work., Xuekun; Xu, Yurui; Feng, Shujun; Huang, Xinyu; Meng, Xia; Chen, Jiao; Guo, Leilei; Ge, Junliang; Chen, Jianmei; Cheng, Li; Gu, Kai; Jiang, Qing; Ning, Xinghai;     Show all 15 Authors
Source:
Chemical communications 2019 v.55 no.61 pp. 8975-8978
ISSN:
1364-548X
Subject:
adverse effects; agonists; blood serum; chemical compounds; chemical reactions; free fatty acids; glucose; glycemic effect; insulin secretion; median effective concentration; mice
Abstract:
... We present a novel free fatty acid receptor 1 (FFA1) agonist, named PAFA, with a strong agonist potency (EC₅₀ = 6.04 nM) and good serum stability. PAFA significantly stimulates insulin secretion in INS-1 cells in a glucose-dependent manner and exhibits high antihyperglycemic effects in db/db mice without adverse effects. ...
DOI:
10.1039/c9cc04040d

9. The doses of plasmid backbone plays a major role in determining the HBV clearance in hydrodynamic injection mouse model

Author:
Zhang, Yong,   et al.   ; Wang, Xian; Zhu, Jianmin; Li, Yue; Ma, Tai; Li, Qun; Xu, Jiegou; Xu, Long;     Show all 8 Authors
Source:
Virology journal 2018 v.15 no.1 pp. 89
ISSN:
1743-422X
Subject:
Hepatitis B virus; agonists; animal models; blood serum; cytokines; genome; hepatitis B antigens; hepatoma; hydrodynamics; immune response; immunohistochemistry; liver; messenger RNA; mice; plasmids; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; risk; signal transduction; staining
Abstract:
... BACKGROUND: Hepatitis B virus (HBV) chronically infects approximately 350 million people worldwide, causing a major risk of liver disease and hepatocellular carcinoma (HCC). Many mouse models have been tried to establish HBV infection through injection with various HBV-containing plasmids. However, it is not well understood that different plasmids, all of which contain the similar HBV genome, even ...
DOI:
10.1186/s12985-018-1002-y
PubMed:
29783985
PubMed Central:
PMC5963156

10. Tributyltin reduces the levels of serum adiponectin and activity of AKT and induces metabolic syndrome in male mice

Author:
Zhang, Cuili,   et al.   ; Yan, Haotian; Guo, Hao; Cheng, Dong; Kou, Ruirui; Si, Jiliang;     Show all 6 Authors
Source:
Environmental toxicology 2018 v.33 no.7 pp. 752-758
ISSN:
1520-4081
Subject:
adiponectin; adverse effects; agonists; blood lipids; blood serum; body weight; epididymis; glucose tolerance; hyperlipidemia; insulin; insulin resistance; intraperitoneal injection; leptin; lipid composition; lipoproteins; liver; males; metabolic syndrome; mice; muscles; phosphorylation; skeletal muscle; tributyltin
Abstract:
... Tributyltin (TBT), a proven environmental obesogen, functions as a nanomolar agonist of the peroxisome proliferator activated receptor‐γ (PPARγ). However, the adverse effects of TBT on metabolism are incompletely understood. In this study, male ICR mice were administered TBT (5 and 50 μg·kg–¹) by an intraperitoneal injection once every 3 days for 30 days from 28 days of age and bred for another 30 ...
DOI:
10.1002/tox.22562

11. Metabolomics Reveals Aryl Hydrocarbon Receptor Activation Induces Liver and Mammary Gland Metabolic Dysfunction in Lactating Mice

Author:
Zhang, Limin,   et al.   ; Belton, Kerry R.; Tian, Yuan; Anitha, Mallappa; Smith, Philip B.; Perdew, Gary H.; Patterson, Andrew D.;     Show all 7 Authors
Source:
Journal of proteome research 2018 v.17 no.4 pp. 1375-1382
ISSN:
1535-3907
Subject:
agonists; amino acids; beta-casein; blood serum; gene expression regulation; genes; glucose; high density lipoprotein; lactalbumin; lactating females; lactation; liver; low density lipoprotein; mammary glands; metabolism; metabolomics; mice; milk production; milk synthesis; nuclear magnetic resonance spectroscopy; proteome; quantitative polymerase chain reaction; tricarboxylic acid cycle; very low density lipoprotein; whey
Abstract:
... The liver and the mammary gland have complementary metabolic roles during lactation. Substrates synthesized by the liver are released into the circulation and are taken up by the mammary gland for milk production. The aryl hydrocarbon receptor (AHR) has been identified as a lactation regulator in mice, and its activation has been associated with myriad morphological, molecular, and functional defe ...
DOI:
10.1021/acs.jproteome.7b00709
PubMed:
29521512
PubMed Central:
PMC5898790

12. GLP-1 Receptor Agonists Stimulate ANGPTL8 Production Through the PI3K/Akt Pathway in a GLP-1 Receptor-Dependent Manner

Author:
Zhang, Jingjing,   et al.   ; Liu, Junling; Yang, Kun; Xiao, Wenhua; Le, Yunyi; Lang, Shan; Wei, Rui; Yang, Jin; Hong, Tianpei;     Show all 9 Authors
Source:
Peptides 2018
ISSN:
0196-9781
Subject:
agonists; antagonists; blood glucose; blood serum; glucagon-like peptide 1; glycohemoglobin; hepatocytes; human cell lines; humans; obesity; patients; phosphatidylinositol 3-kinase; secretion; China
Abstract:
... The level of serum angiopoietin-like protein 8 (ANGPTL8), a novel hepatokine, is associated with obesity and type 2 diabetes mellitus (T2DM). To investigate whether serum ANGPTL8 level in patients with T2DM was affected by treatment with exenatide, a glucagon-like peptide-1 receptor (GLP-1R) agonist, and to determine whether and how GLP-1R agonists regulated ANGPTL8 production in hepatocytes. A mu ...
DOI:
10.1016/j.peptides.2018.07.001

13. CpG and transfer factor assembled on nanoparticles reduce tumor burden in mice glioma model

Author:
Zhang, Xiao-Hua,   et al.   ; Miao, Yi-Feng; Lv, Tao; Wang, Ran; Wu, Hui; Yang, Shao-Feng; Dai, Jiong;     Show all 7 Authors
Source:
RSC advances 2017 v.7 no.19 pp. 11644-11651
ISSN:
2046-2069
Subject:
Toll-like receptors; agonists; blood serum; cell viability; cell-mediated immunity; dendritic cells; glioma; granulocyte-macrophage colony-stimulating factor; in vivo studies; interleukin-6; macrophages; mice; models; nanogold; nanoparticles; therapeutics; tumor necrosis factors; viability assays; zeta potential
Abstract:
... This work describes the use of a transfer factor, a low molecular protein that can transfer cell mediated immunity from donor to recipient, and CpG, a clinically relevant toll-like receptor agonist, for treating glioma. Transfer factor and CpG were assembled onto gold nanoparticles via layer-by-layer assembly. The modified nanoparticles (i.e. particles assembled with transfer factor and CpG) were ...
DOI:
10.1039/c6ra17395k

14. Ischemic Preconditioning protects hepatocytes from ischemia-reperfusion injury via TGR5-mediated anti-apoptosis

Author:
Zhang, Feng,   et al.   ; Zhuang, Lin; Fan, Ye; Lu, Ling; Ding, Wenbin; Ni, Chuangye; Wang, Xuehao; Rao, Jianhua;     Show all 8 Authors
Source:
Biochemical and biophysical research communications 2016 v.473 pp. 966-972
ISSN:
0006-291X
Subject:
Western blotting; agonists; alanine transaminase; apoptosis; bile acids; blood serum; caspase-3; cytokines; hepatocytes; hypoxia; knockout mutants; liver; liver diseases; models; protective effect; tissues
Abstract:
... Ischemic preconditioning (IP) has been shown to protect hepatic tissue from liver ischemia-reperfusion injury (IRI). TGR5, as a new-type bile acid receptor, has been shown protective roles in several liver diseases. However, the relationship between TGR5 and IP is still unknown. This study investigated effects of IP on TGR5 as well as the roles of TGR5 on hepatic tissue lesions and apoptosis in li ...
DOI:
10.1016/j.bbrc.2016.03.162

15. Activation of farnesoid X receptor (FXR) protects against fructose-induced liver steatosis via inflammatory inhibition and ADRP reduction

Author:
Zhang, Xingwang,   et al.   ; Liu, Xijun; Xue, Ruyi; Ji, Lingling; Wu, Jian; Gu, Jianxin; Zhou, Meiling; Chen, She;     Show all 8 Authors
Source:
Biochemical and biophysical research communications 2014 v.450 pp. 117-123
ISSN:
0006-291X
Subject:
agonists; blood serum; dose response; endotoxins; fatty liver; fructose; intestines; lipopolysaccharides; liver; mice; models; palmitic acid; triacylglycerols; tumor necrosis factor-alpha
Abstract:
... Fructose is a key dietary factor in the development of nonalcoholic fatty liver disease (NAFLD). Here we investigated whether WAY-362450 (WAY), a potent synthetic and orally active FXR agonist, protects against fructose-induced steatosis and the underlying mechanisms. C57BL/6J mice, fed 30% fructose for 8weeks, were treated with or without WAY, 30mg/kg, for 20days. The elevation of serum and hepat ...
DOI:
10.1016/j.bbrc.2014.05.072

16. Osthole ameliorates insulin resistance by increment of adiponectin release in high-fat and high-sucrose-induced fatty liver rats

Author:
Zhang, Yan,   et al.   ; Qi, Zhigang; Xue, Jie; Wang, Hengbin; Xie, Meilin;     Show all 5 Authors
Source:
Planta medica 2011 v.77 no.3 pp. 231-235
ISSN:
0032-0943
Subject:
adiponectin; agonists; animal models; blood glucose; blood serum; cholesterol; fasting; fatty liver; free fatty acids; homeostasis; inflammation; insulin; insulin resistance; liver; rats; triacylglycerols; weight gain
Abstract:
... The objectives of this study were to determine the effect of osthole on the insulin resistance (IR) in high-fat and high-sucrose-induced fatty liver rats and to investigate its potential mechanisms. The rat model was established by orally feeding high-fat and high-sucrose emulsion by gavage for 9 weeks. The experimental rats were treated with osthole 5 and 10 mg/kg, lipanthyl 30 mg/kg, and rosigli ...
DOI:
10.1055/s-0030-1250268
PubMed:
20717873

17. Alteration of sweet taste in high-fat diet induced obese rats after 4 weeks treatment with exenatide

Author:
Zhang, Xiao-juan,   et al.   ; Wang, Yu-qing; Long, Yang; Wang, Lei; Li, Yun; Gao, Fa-bao; Tian, Hao-ming;     Show all 7 Authors
Source:
Peptides 2013 v.47 pp. 115-123
ISSN:
0196-9781
Subject:
agonists; appetite; blood glucose; blood serum; body weight; brain; food intake; glucagon-like peptide 1; high fat diet; leptin; leptin receptors; lipid metabolism; metabolic diseases; palatability; palps; rats; taste receptors; taste sensitivity; weight loss
Abstract:
... Exenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist, is effective in inducing weight loss. The exact mechanisms are not fully understood. Reduced appetite and food intake may play important roles. Sweet taste contributes to food palatability, which promotes appetite. Interestingly, GLP-1 and its receptor are expressed in the taste buds of rodents and their interaction has an effect on me ...
DOI:
10.1016/j.peptides.2013.07.015

18. Natural killer cell intrinsic toll-like receptor MyD88 signaling contributes to IL-12-dependent IFN-γ production by mice during infection with Toxoplasma gondii

Author:
Zhang, Jie,   et al.   ; Ge, Yiyue; Chen, Jinling; Qiu, Xiaoyan; Cui, Lunbiao; Qi, Yuhua; Liu, Xinjian; Qiu, Jingfan; Shi, Zhiyang; Lun, Zhaorong; Shen, Jilong; Wang, Yong;     Show all 12 Authors
Source:
International journal for parasitology 2014 v.44 no.7 pp. 475-484
ISSN:
0020-7519
Subject:
Toll-like receptors; Toxoplasma gondii; agonists; antigens; blood serum; dendritic cells; heat-shock protein 70; interferon-gamma; interleukin-12; mice; mitogen-activated protein kinase; mortality; natural killer cells; parasites; secretion; toxoplasmosis; transcription factor NF-kappa B
Abstract:
... Myeloid differentiation factor 88 (MyD88)-dependent IL-12 secretion by dendritic cells is critical for natural killer cell-mediated IFN-γ production and innate resistance to Toxoplasma gondii. Although MyD88−/− mice challenged with T. gondii have defective IL-12 responses and succumb to infection, administration of IL-12 to MyD88−/− mice fails to prevent acute mortality, suggesting that MyD88 may ...
DOI:
10.1016/j.ijpara.2014.03.004

19. An Assessment of Androgenic/Anti-androgenic Effects of GH Transgenic Carp by Hershberger Assay

Author:
ZHANG, WenZhong,   et al.   ; LIU, YuMei; YONG, Ling; ZHAO, XiaoHong; JIA, XuDong; LI, Ning;     Show all 6 Authors
Source:
Biomedical and environmental sciences 2011 v.24 no.4 pp. 445-449
ISSN:
0895-3988
Subject:
accessory sex glands; agonists; antagonists; blood serum; body weight; carp; follicle-stimulating hormone; luteinization; luteinizing hormone; males; oral administration; propionic acid; rats; screening; solvents; somatotropin; testosterone; transgenic animals
Abstract:
... OBJECTIVE: To evaluate the androgenic and anti-androgenic effects of GH (growth hormone) transgenic carp in male rats. METHODS: Hershberger assay was carried out in castrated male SD rats aged 4-5 weeks. Testosterone propionate (TP) (0.4 mg/kg BW) was administrated for a positive control, GH transgenic carp (3.0 g/kg BW)+TP (0.4 mg/kg BW), parental carp (3.0 g/kg BW) + TP (0.4 mg/kg BW), and fluta ...
DOI:
10.3967/0895-3988.2011.04.017

20. Three-month subchronic intramuscular toxicity study of rotigotine-loaded microspheres in Cynomolgus monkeys

Author:
Zhang, Jianzhao,   et al.   ; Tian, Jingwei; Du, Guangying; Ye, Liang; Yu, Xin; Wang, Hongbo; Yu, Pengfei; Fu, Fenghua; Liu, Wanhui; Li, Youxin; Cen, Xiaobo; Guan, Xiaolin;     Show all 12 Authors
Source:
Food and chemical toxicology 2013 v.52 pp. 143-152
ISSN:
0278-6915
Subject:
Macaca fascicularis; Parkinson disease; adrenal cortex; agonists; atrophy; blood serum; clinical trials; dopamine; dopamine receptors; drug carriers; drugs; embolism; foam cells; granuloma; intramuscular injection; lymph; monkeys; neutrophils; no observed adverse effect level; prolactin; sinuses; spleen; subchronic toxicity; toxicology
Abstract:
... Continuous dopaminergic stimulation (CDS) is an important drug development strategy in the treatment of Parkinson’s disease (PD). Rotigotine is a non-ergoline D3/D2/D1 dopamine receptor agonist for treating PD. As a new treatment option for CDS, rotigotine-loaded microspheres (RoMS), long-acting sustained-release microspheres with poly(lactide-co-glycolide) as drug carrier, are now being evaluated ...
DOI:
10.1016/j.fct.2012.11.010