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- Abou-Elkhair, Reham A. I., et al. Show all 4 Authors
- Organic letters 2016 v.18 no.18 pp. 4714-4717
- DNA; aldehydes; amidines; benzimidazole; chemical reactions; chemical structure; diamines; dimethyl sulfoxide; lithium; nitriles; pharmaceutical industry
- ... Trimethylsilyl-transient protection successfully allowed the use of lithium hexamethyldisilazane to prepare benzimidazole (BI) and 4-azabenzimidazole (azaBI) amidines from nitriles in 58–88% yields. This strategy offers a much better choice to prepare BI/azaBI amidines than the lengthy, low-yielding Pinner reaction. Synthesis of aza/benzimidazole rings from aromatic diamines and aldehydes was affe ...
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