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- Xu, Haitong, et al. Show all 7 Authors
- Journal of organic chemistry 2019 v.84 no.16 pp. 10526-10534
- aldehydes; catalytic activity; chemical reactions; chemical structure; enantioselectivity; organic chemistry; stereoselective synthesis
- ... Chiral-substituted 3-amino tetrahydro-2H-pyran-2-ones were prepared in excellent enantioselectivities (up to 99% ee) via an organo-catalyzed cascade procedure with N-TFA-Gly-Bt and α,β-unsaturated aldehydes as the substrates. The corresponding tetrahydro-2H-pyran-2-ones can be used for further synthetic transformations that furnish chiral-substituted 3-aminopiperidin-2-ones with high levels of ste ...